Page last updated: 2024-08-26

asoxime chloride and tabun

asoxime chloride has been researched along with tabun in 47 studies

Research

Studies (47)

Timeframe	Studies, this research(%)	All Research%
pre-1990	9 (19.15)	18.7374
1990's	7 (14.89)	18.2507
2000's	16 (34.04)	29.6817
2010's	14 (29.79)	24.3611
2020's	1 (2.13)	2.80

Authors

Authors	Studies
Boulet, CA; Clement, JG; Hansen, AS	1
Goulet, JC; Hand, BT; Lundy, PM	1
Hamilton, MG; Lundy, PM	1
Clement, JG; Gennings, C; Shiloff, JD	1
Pantelić, D	1
Artursson, E; Bucht, G; Puu, G	1
De Bisschop, HC; Nicaise, M; Willems, JL	1
Bosković, B; Cetković, S; Cosić, M; Cvetković, M; Jandrić, D	1
Bosković, B; Jovanović, D; Kovacević, V	1
Clement, JG	1
Kleine, A; Szinicz, L; Worek, F	1
Melchers, BP; Philippens, IH; Wolthuis, OL	1
Kirchner, T; Szinicz, L; Worek, F	1
Koplovitz, I; Stewart, JR	1
Bruijnzeel, PL; Busker, RW; Melchers, BP; van Helden, HP	1
Knopff, O; Szinicz, L; Widmann, R; Worek, F	1
Kassa, J; Krejèová, G	1
Kassa, J; Kuca, K	1
Cabal, J; Kassa, J; Kuca, K	2
Cabal, J; Hrabinova, M; Jun, D; Kassa, J; Kuca, K	1
Reiner, E; Simeon-Rudolf, V	1
Akfur, C; Artursson, E; Boman, M; Börjegren, S; Ekström, F; Pang, YP	1
Karasova, J; Kassa, J	1
Bajgar, J; Jun, D; Kuca, K	1
Cabal, J; Jun, D; Kuca, K; Musilek, K	1
Jun, D; Kassa, J; Kuca, K	1
Bajgar, J; Jun, D; Kassa, J; Kuca, K	1
Karasova, J; Kassa, J; Kuca, K; Musilek, K	1
Humlicek, V; Kassa, J	1
Jung, YS; Karasova, J; Kassa, J; Kuca, K; Musilek, K	1
Bajgar, J; Caisberger, F; Karasova, JZ; Kassa, J; Misik, J; Pavlikova, R	1
Akfur, C; Artursson, E; Ekström, F; Hörnberg, A; Worek, F	1
Aurbek, N; Herkert, NM; Koller, M; Thiermann, H; Worek, F	1
Bajgar, J; Blaha, V; Cabal, J; Fusek, J; Karasova, JZ; Kassa, J; Tesarova, S	1
Caisberger, F; Jung, YS; Karasova, JZ; Kassa, J; Kuca, K; Musilek, K	1
Karasova, JZ; Kassa, J; Kuca, K; Musilek, K	1
Bajgar, J; Capek, L; Fusek, J; Hajek, P; Jun, D; Kassa, J; Krs, O; Kuca, K; Paseka, A; Slizova, D; Zdarova, JK	1
Bajgar, J; Jung, YS; Karasova, JZ; Kassa, J; Kuca, K; Musilek, K; Pavlikova, R	1
Baati, R; Gillon, E; Jean, L; Mercey, G; Nachon, F; Renard, PY; Saint-André, G; Verdelet, T; Wagner, A	1
Hamilton, MG; Lundy, PM; Mikler, J; Sawyer, TW	1
Bumm, R; Friess, H; Gerhardus, J; Langer, P; Mihaljevic, AL; Niessen, KV; Seeger, T; Thiermann, H; Worek, F	1
Akfur, C; Andersson, PO; Artursson, E; Börjegren, S; Ekström, F; Linusson, A	1
Aas, P; Enger, S; Mariussen, E; Myhrer, T	1
Koller, M; Thiermann, H; Wille, T; Worek, F	1
C C França, T; Cuya, T; da Silva, JAV; Gonçalves, ADS; Kuca, K; Ramalho, TC	1
Caisberger, F; Hatlapatková, J; Hepnarová, V; Kassa, J; Pejchal, J; Žďárová Karasová, J	1

Reviews

2 review(s) available for asoxime chloride and tabun

Article	Year
Pharmacological effects of oximes: how relevant are they? Archives of toxicology, 1996, Volume: 70, Issue:12 Topics: Animals; Antidotes; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Disease Models, Animal; Organophosphate Poisoning; Organophosphates; Oximes; Poisoning; Pyridinium Compounds; Receptors, Cholinergic; Respiration; Soman; Synaptic Transmission	1996
Comparative protective effects of HI-6 and MMB-4 against organophosphorous nerve agent poisoning. Toxicology, 2011, Jul-29, Volume: 285, Issue:3 Topics: Antidotes; Chemical Warfare Agents; Humans; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman	2011

Other Studies

45 other study(ies) available for asoxime chloride and tabun

Article	Year
Efficacy of HLö-7 and pyrimidoxime as antidotes of nerve agent poisoning in mice. Archives of toxicology, 1992, Volume: 66, Issue:3 Topics: Animals; Antidotes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Imidazoles; Lethal Dose 50; Male; Mice; Neuromuscular Blocking Agents; Organophosphate Poisoning; Organophosphates; Oximes; Pyridines; Pyridinium Compounds; Sarin; Soman	1992
Hormone- and dose schedule-dependent protection by HI-6 against soman and tabun poisoning. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1989, Volume: 12, Issue:3 Topics: Animals; Body Weight; Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Guinea Pigs; Lethal Dose 50; Male; Obidoxime Chloride; Orchiectomy; Organophosphates; Organophosphorus Compounds; Ovariectomy; Oximes; Pyridinium Compounds; Rats; Rats, Inbred Strains; Soman; Species Specificity; Testosterone; Time Factors	1989
HI-6 therapy of soman and tabun poisoning in primates and rodents. Archives of toxicology, 1989, Volume: 63, Issue:2 Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Guinea Pigs; Lethal Dose 50; Macaca mulatta; Male; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Inbred Strains; Respiratory Muscles; Soman	1989
Efficacy of a combination of acetylcholinesterase reactivators, HI-6 and obidoxime, against tabun and soman poisoning of mice. Archives of toxicology, 1987, Volume: 61, Issue:1 Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Therapy, Combination; Male; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Soman	1987
[Comparative reactivation efficacy of the oximes HI-6 and HGG-12 in the central nervous system and blood of rats poisoned with nerve gases used in warfare]. Godisnjak Vojnomedicinske akademije = Annual of the Military Medical Academy, 1986, Volume: 28 Topics: Acetylcholinesterase; Animals; Central Nervous System; Chemical Warfare; Cholinesterase Inhibitors; Cholinesterase Reactivators; Gas Poisoning; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats; Sarin; Soman	1986
Reactivation of nerve agent inhibited human acetylcholinesterases by HI-6 and obidoxime. Biochemical pharmacology, 1986, May-01, Volume: 35, Issue:9 Topics: Acetylcholinesterase; Caudate Nucleus; Cholinesterase Reactivators; Edrophonium; Humans; Muscles; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman; Stereoisomerism	1986
Delayed neuropathy by the organophosphorus nerve agents soman and tabun. Archives of toxicology, 1984, Volume: 55, Issue:1 Topics: Animals; Chickens; Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Lethal Dose 50; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Oximes; Peripheral Nervous System Diseases; Pyridinium Compounds; Soman	1984
Effect of PAM-2 Cl, HI-6, and HGG-12 in poisoning by tabun and its thiocholine-like analog in the rat. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1984, Volume: 4, Issue:2 Pt 2 Topics: Animals; Atropine; Choline; Cholinesterase Reactivators; Cholinesterases; Female; Guinea Pigs; Heart; Humans; Lethal Dose 50; Male; Muscle Contraction; Muscle, Smooth; Organophosphate Poisoning; Organophosphates; Oximes; Phrenic Nerve; Pralidoxime Compounds; Pyridinium Compounds; Rats; Thiocholine	1984
PAM-2 Cl, HI-6, and HGG-12 in soman and tabun poisoning. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1984, Volume: 4, Issue:2 Pt 2 Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazepam; Dogs; Guinea Pigs; Lethal Dose 50; Male; Mice; Organophosphate Poisoning; Organophosphates; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Soman; Species Specificity	1984
HI-6: reactivation of central and peripheral acetylcholinesterase following inhibition by soman, sarin and tabun in vivo in the rat. Biochemical pharmacology, 1982, Apr-01, Volume: 31, Issue:7 Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Organophosphates; Organophosphorus Compounds; Oximes; Peripheral Nerves; Pyridinium Compounds; Rats; Rats, Inbred Strains; Sarin; Soman	1982
Effect of pyridostigmine pretreatment on cardiorespiratory function in tabun poisoning. Human & experimental toxicology, 1995, Volume: 14, Issue:8 Topics: Animals; Atropine; Blood Pressure; Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Guinea Pigs; Heart Rate; Hemodynamics; Injections, Intravenous; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridines; Pyridinium Compounds; Pyridostigmine Bromide; Respiration	1995
Efficacy of HI-6 and HLö-7 in preventing incapacitation following nerve agent poisoning. Pharmacology, biochemistry, and behavior, 1994, Volume: 49, Issue:4 Topics: Animals; Atropine; Behavior, Animal; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Conditioning, Operant; Electroencephalography; Guinea Pigs; Lethal Dose 50; Organophosphates; Oximes; Pyridines; Pyridinium Compounds; Respiratory Mechanics; Soman	1994
Treatment of tabun poisoned guinea-pigs with atropine, HLö 7 or HI 6: effect on respiratory and circulatory function. Archives of toxicology, 1994, Volume: 68, Issue:4 Topics: Animals; Atropine; Blood Circulation; Cholinesterase Reactivators; Female; Guinea Pigs; Lethal Dose 50; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridines; Pyridinium Compounds; Respiration	1994
A comparison of the efficacy of HI6 and 2-PAM against soman, tabun, sarin, and VX in the rabbit. Toxicology letters, 1994, Feb-15, Volume: 70, Issue:3 Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazepam; Lethal Dose 50; Male; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Rabbits; Sarin; Soman; Specific Pathogen-Free Organisms	1994
Reactivating potency of obidoxime, pralidoxime, HI 6 and HLö 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds. Archives of toxicology, 1998, Volume: 72, Issue:4 Topics: Acetylcholinesterase; Antidotes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocytes; Humans; Obidoxime Chloride; Organophosphates; Oximes; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Soman	1998
Neuroprotective effects of currently used antidotes in tabun-poisoned rats. Pharmacology & toxicology, 2003, Volume: 92, Issue:6 Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Reactivators; Drug Therapy, Combination; Male; Motor Activity; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar	2003
In vitro reactivation of acetylcholinesterase using the oxime K027. Veterinary and human toxicology, 2004, Volume: 46, Issue:1 Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Structure-Activity Relationship	2004
Specification of the structure of oximes able to reactivate tabun-inhibited acetylcholinesterase. Basic & clinical pharmacology & toxicology, 2004, Volume: 95, Issue:2 Topics: Acetylcholine; Acetylcholinesterase; Animals; Drug Evaluation, Preclinical; Lethal Dose 50; Male; Molecular Conformation; Organophosphates; Oximes; Phosphorylation; Pyridinium Compounds; Quantitative Structure-Activity Relationship; Rats; Rats, Wistar	2004
A comparison of the efficacy of a bispyridinium oxime--1,4-bis-(2-hydroxyiminomethylpyridinium) butane dibromide and currently used oximes to reactivate sarin, tabun or cyclosarin-inhibited acetylcholinesterase by in vitro methods. Die Pharmazie, 2004, Volume: 59, Issue:10 Topics: Acetylcholinesterase; Animals; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar; Sarin	2004
In vitro potency of H oximes (HI-6, HLö-7), the oxime BI-6, and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase. Journal of toxicology and environmental health. Part A, 2006, Volume: 69, Issue:15 Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Rats; Rats, Wistar; Trimedoxime	2006
Pyridinium, imidazolium and quinuclidinium compounds: toxicity and antidotal effects against the nerve agents Tabun and Soman. Arhiv za higijenu rada i toksikologiju, 2006, Volume: 57, Issue:2 Topics: Animals; Antidotes; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Mice; Obidoxime Chloride; Organophosphates; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Soman; Trimedoxime	2006
Crystal structures of acetylcholinesterase in complex with HI-6, Ortho-7 and obidoxime: structural basis for differences in the ability to reactivate tabun conjugates. Biochemical pharmacology, 2006, Aug-28, Volume: 72, Issue:5 Topics: Acetylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Crystallography, X-Ray; Hydrogen Bonding; Models, Molecular; Nitrogen; Obidoxime Chloride; Organophosphates; Oximes; Protein Conformation; Pyridinium Compounds	2006
A comparison of the potency of newly developed oximes (K074, K075) and commonly used oximes (obidoxime, HI-6) to counteract tabun-induced neurotoxicity in rats. Toxicology, 2007, Jan-05, Volume: 229, Issue:1-2 Topics: Animals; Antidotes; Atropine; Behavior, Animal; Butanes; Chemical Warfare Agents; Cholinergic Antagonists; Dose-Response Relationship, Drug; Injections, Intramuscular; Lacrimal Apparatus; Male; Miosis; Molecular Structure; Muscle Tonus; Neurotoxicity Syndromes; Obidoxime Chloride; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Tears; Time Factors; Toxicity Tests; Treatment Outcome	2007
Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro. Drug and chemical toxicology, 2007, Volume: 30, Issue:1 Topics: Animals; Brain; Chemical Warfare Agents; Chlorpyrifos; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar; Sarin; Soman; Tissue Extracts; Trimedoxime	2007
In vitro reactivation potency of acetylcholinesterase reactivators--K074 and K075--to reactivate tabun-inhibited human brain cholinesterases. Neurotoxicity research, 2007, Volume: 11, Issue:2 Topics: Acetylcholinesterase; Butanes; Caudate Nucleus; Cholinesterase Inhibitors; Cholinesterase Reactivators; Enzyme Activation; Humans; In Vitro Techniques; Obidoxime Chloride; Organophosphates; Oximes; Pralidoxime Compounds; Pyridinium Compounds	2007
A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-and tabun-poisoned rats. Journal of enzyme inhibition and medicinal chemistry, 2007, Volume: 22, Issue:3 Topics: Animals; Antidotes; Brain; Butanes; Cholinesterase Reactivators; Drug Evaluation, Preclinical; Male; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Structure-Activity Relationship	2007
Comparison of reactivating and therapeutic efficacy of two salts of the oxime HI-6 against tabun, soman and cyclosarin in rats. Basic & clinical pharmacology & toxicology, 2007, Volume: 101, Issue:5 Topics: Animals; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Lethal Dose 50; Male; Muscarinic Antagonists; Organophosphates; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Soman	2007
An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice. Toxicology, 2008, Jan-20, Volume: 243, Issue:3 Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Chromatography, High Pressure Liquid; Drug Therapy, Combination; Injections, Intramuscular; Lethal Dose 50; Male; Mice; Molecular Structure; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Seizures; Species Specificity; Toxicity Tests, Acute; Trimedoxime	2008
A comparison of the potency of newly developed oximes (K074, K075) and currently available oximes (obidoxime, trimedoxime, HI-6) to counteract acute toxic effects of tabun and cyclosarin in mice. Drug and chemical toxicology, 2008, Volume: 31, Issue:1 Topics: Animals; Antidotes; Atropine; Butanes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Lethal Dose 50; Male; Mice; Muscarinic Antagonists; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Oximes; Poisoning; Pyridinium Compounds; Trimedoxime	2008
A comparison of the therapeutic and reactivating efficacy of newly developed oximes (K117, K127) and currently available oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice. Drug and chemical toxicology, 2008, Volume: 31, Issue:3 Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Cholinesterase Inhibitors; Diaphragm; Male; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Trimedoxime	2008
The influence of combinations of oximes on the reactivating and therapeutic efficacy of antidotal treatment of tabun poisoning in rats and mice. Journal of applied toxicology : JAT, 2010, Volume: 30, Issue:2 Topics: Acetylcholinesterase; Animals; Antidotes; Cholinesterase Reactivators; Drug Therapy, Combination; Male; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar	2010
Reactivation of tabun-hAChE investigated by structurally analogous oximes and mutagenesis. Toxicology, 2009, Nov-30, Volume: 265, Issue:3 Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Cloning, Molecular; Humans; Molecular Structure; Mutagenesis, Site-Directed; Organophosphates; Oximes; Pyridinium Compounds; Recombinant Proteins; Sequence Analysis, DNA; Templates, Genetic	2009
Kinetic analysis of interactions of different sarin and tabun analogues with human acetylcholinesterase and oximes: is there a structure-activity relationship? Chemico-biological interactions, 2010, Sep-06, Volume: 187, Issue:1-3 Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Enzyme Activation; Humans; Kinetics; Obidoxime Chloride; Organophosphates; Oximes; Protein Binding; Pyridinium Compounds; Sarin; Structure-Activity Relationship	2010
Tabun-inhibited rat tissue and blood cholinesterases and their reactivation with the combination of trimedoxime and HI-6 in vivo. Chemico-biological interactions, 2010, Sep-06, Volume: 187, Issue:1-3 Topics: Acetylcholinesterase; Animals; Central Nervous System; Cholinesterase Reactivators; Drug Therapy, Combination; Enzyme Activation; Female; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Trimedoxime	2010
A comparison of reactivating and therapeutic efficacy of the oxime K203 and its fluorinated analog (KR-22836) with currently available oximes (obidoxime, trimedoxime, HI-6) against tabun in rats and mice. Journal of enzyme inhibition and medicinal chemistry, 2010, Volume: 25, Issue:4 Topics: Animals; Antidotes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Mice; Obidoxime Chloride; Organophosphates; Oximes; Pyridinium Compounds; Rats; Trimedoxime	2010
A comparison of the reactivating and therapeutic efficacy of newly developed oximes (K347, K628) with commonly used oximes (obidoxime, HI-6) against tabun in rats and mice. Drug and chemical toxicology, 2010, Volume: 33, Issue:3 Topics: Acetylcholinesterase; Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Lethal Dose 50; Male; Mice; Obidoxime Chloride; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar	2010
A comparison of tabun-inhibited rat brain acetylcholinesterase reactivation by three oximes (HI-6, obidoxime, and K048) in vivo detected by biochemical and histochemical techniques. Journal of enzyme inhibition and medicinal chemistry, 2010, Volume: 25, Issue:6 Topics: Acetylcholinesterase; Animals; Atropine; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Frontal Lobe; GPI-Linked Proteins; Lethal Dose 50; Obidoxime Chloride; Organ Specificity; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Reticular Formation	2010
A comparison of reactivating and therapeutic efficacy of bispyridinium acetylcholinesterase reactivator KR-22934 with the oxime K203 and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice. Toxicology mechanisms and methods, 2011, Volume: 21, Issue:3 Topics: Acetylcholinesterase; Animals; Antidotes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Mice; Obidoxime Chloride; Organophosphates; Oximes; Poisoning; Pyridinium Compounds; Rats; Rats, Wistar; Trimedoxime	2011
First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase. Chemical communications (Cambridge, England), 2011, May-14, Volume: 47, Issue:18 Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Erythrocytes; Humans; Molecular Structure; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Oximes; Pyridines; Pyridinium Compounds; Soman	2011
Restoration of nerve agent inhibited muscle force production in human intercostal muscle strips with HI 6. Toxicology letters, 2011, Sep-25, Volume: 206, Issue:1 Topics: Acetylcholinesterase; Aged; Chemical Warfare Agents; Cholinesterase Reactivators; Electric Stimulation; Humans; In Vitro Techniques; Intercostal Muscles; Muscle Strength; Neuromuscular Junction; Organophosphates; Oximes; Pyridinium Compounds; Sarin; Soman	2011
Catalytic-site conformational equilibrium in nerve-agent adducts of acetylcholinesterase: possible implications for the HI-6 antidote substrate specificity. Biochemical pharmacology, 2013, May-01, Volume: 85, Issue:9 Topics: Acetylcholinesterase; Animals; Antidotes; Catalytic Domain; Chemical Warfare Agents; Cholinesterase Inhibitors; Crystallography, X-Ray; Humans; Mice; Models, Molecular; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Protein Conformation; Pyridinium Compounds; Spectrometry, Fluorescence; Substrate Specificity	2013
Supralethal poisoning by any of the classical nerve agents is effectively counteracted by procyclidine regimens in rats. Neurotoxicology, 2015, Volume: 50 Topics: Animals; Anticonvulsants; Antidotes; Body Weight; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Lethal Dose 50; Levetiracetam; Male; Nerve Agents; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Piracetam; Procyclidine; Pyridinium Compounds; Rats; Rats, Wistar; Seizures; Soman	2015
Reactivation of nerve agent-inhibited human acetylcholinesterase by obidoxime, HI-6 and obidoxime+HI-6: Kinetic in vitro study with simulated nerve agent toxicokinetics and oxime pharmacokinetics. Toxicology, 2016, 03-28, Volume: 350-352 Topics: Acetylcholinesterase; Cholinesterase Reactivators; Drug Therapy, Combination; Humans; Inhalation Exposure; Injections, Intramuscular; Models, Biological; Nerve Agents; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Toxicokinetics	2016
The role of the oximes HI-6 and HS-6 inside human acetylcholinesterase inhibited with nerve agents: a computational study. Journal of biomolecular structure & dynamics, 2018, Volume: 36, Issue:13 Topics: Acetylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Nerve Agents; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin	2018
A Comparison of the Neuroprotective and Reactivating Efficacy of a Novel Bispyridinium Oxime K870 with Commonly Used Pralidoxime and the Oxime HI-6 in Tabun-Poisoned Rats. Acta medica (Hradec Kralove), 2021, Volume: 64, Issue:3 Topics: Acetylcholinesterase; Animals; Antidotes; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Organophosphates; Oximes; Poisons; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar	2021