Page last updated: 2024-08-26

asoxime chloride and sarin

asoxime chloride has been researched along with sarin in 45 studies

Research

Studies (45)

TimeframeStudies, this research(%)All Research%
pre-19907 (15.56)18.7374
1990's8 (17.78)18.2507
2000's16 (35.56)29.6817
2010's13 (28.89)24.3611
2020's1 (2.22)2.80

Authors

AuthorsStudies
Agnusdei, M; Belinskaya, T; Borriello, M; Brindisi, M; Butini, S; Campiani, G; Catalanotti, B; Fattorusso, C; Fiorini, I; Gemma, S; Nacci, V; Novellino, E; Panico, A; Persico, M; Ros, S; Saxena, A1
Boulet, CA; Clement, JG; Hansen, AS1
Busker, RW; Melchers, BP; van der Wiel, HJ; van Helden, HP; Zijlstra, JJ2
Bessette, E; Clement, JG; Erhardt, N; Rosario, S1
Clement, JG; Shiloff, JD1
Pantelić, D1
Artursson, E; Bucht, G; Puu, G1
Chou, TC; Li, FZ; Sun, MC1
Van der Wiel, HJ; Vanwersch, RA; Wolthuis, O1
Lundy, PM; Shih, TM1
Clement, JG1
Kirchner, T; Szinicz, L; Worek, F1
Koplovitz, I; Stewart, JR1
Ashani, Y; Asher, JM; Brecht, KM; Caranto, GR; Larrison, RW; Maxwell, DM; Raveh, L; Schutz, MB; Waibel, KH; Wolfe, AD1
Bajgar, J; Kassa, J1
Qin, JC; Sun, MJ; Wei, WL1
Eyer, P; Kiderlen, D; Szinicz, L; Thiermann, H; Worek, F1
Eyer, P; Reiter, G; Szinicz, L; Worek, F1
Kassa, J; Krejcová, G; Vachek, J2
Kassa, J; Kuca, K1
Cabal, J; Kassa, J; Kuca, K2
Becker, G; Gutzeit, D; Kawan, A; Szinicz, L; Worek, F1
Bajgar, J; Jun, D; Kuca, K1
Jun, D; Kuca, K1
Jun, D; Koleckar, V; Kuca, K; Marek, J; Picha, J1
Koplovitz, I; Maxwell, DM; Sweeney, RE; Worek, F1
Aurbek, N; Herkert, NM; Koller, M; Thiermann, H; Worek, F2
Artursson, E; Ekström, F; Hammarström, LG; Hörnberg, A; Pang, YP; Schneider, G1
Caisberger, F; Karasova, JZ; Kassa, J; Sepsova, V1
Hamilton, MG; Lundy, PM; Mikler, J; Sawyer, TW1
Bumm, R; Friess, H; Gerhardus, J; Langer, P; Mihaljevic, AL; Niessen, KV; Seeger, T; Thiermann, H; Worek, F1
Kassa, J; Kunesova, G1
Karasova, JZ; Kassa, J; Misik, J1
Brecht, KM; Maxwell, DM; Sweeney, RE1
Horova, A; Kassa, J; Matouskova, L; Musilek, K; Sepsova, V1
Akfur, C; Allgardsson, A; Berg, L; Ekström, FJ; Hörnberg, A; Linusson, A; Worek, F1
Koller, M; Thiermann, H; Wille, T; Worek, F1
Chen, J; Guo, L; Tang, J; Xie, J; Xie, Y; Xu, B; Yan, L1
C C França, T; Cuya, T; da Silva, JAV; Gonçalves, ADS; Kuca, K; Ramalho, TC1
Bird, M; Green, AC; Kassa, J; Tattersall, JEH; Timperley, CM; Williams, RL1
Andrýs, R; Karasová, JŽ; Kassa, J; Klusoňová, A; Lísa, M1

Reviews

1 review(s) available for asoxime chloride and sarin

ArticleYear
Comparative protective effects of HI-6 and MMB-4 against organophosphorous nerve agent poisoning.
    Toxicology, 2011, Jul-29, Volume: 285, Issue:3

    Topics: Antidotes; Chemical Warfare Agents; Humans; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman

2011

Other Studies

44 other study(ies) available for asoxime chloride and sarin

ArticleYear
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Acetylcholinesterase; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Computational Biology; Crystallography, X-Ray; Drug Design; Humans; Models, Molecular; Protein Conformation; Structure-Activity Relationship; Tacrine

2008
Efficacy of HLö-7 and pyrimidoxime as antidotes of nerve agent poisoning in mice.
    Archives of toxicology, 1992, Volume: 66, Issue:3

    Topics: Animals; Antidotes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Imidazoles; Lethal Dose 50; Male; Mice; Neuromuscular Blocking Agents; Organophosphate Poisoning; Organophosphates; Oximes; Pyridines; Pyridinium Compounds; Sarin; Soman

1992
Organophosphate poisoning: a method to test therapeutic effects of oximes other than acetylcholinesterase reactivation in the rat.
    Toxicology, 1991, Volume: 69, Issue:3

    Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; In Vitro Techniques; Lethal Dose 50; Male; Neuromuscular Junction; Oximes; Pyridinium Compounds; Rats; Sarin; Survival Analysis; Synaptic Transmission

1991
Soman and sarin inhibition of molecular forms of acetylcholinesterase in mice. Time course of recovery and reactivation by the oxime HI-6.
    Biochemical pharmacology, 1991, Jul-05, Volume: 42, Issue:2

    Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diaphragm; Hypothalamus; Isoenzymes; Male; Mice; Oximes; Pyridinium Compounds; Sarin; Soman; Time Factors

1991
Comparison of serum concentrations of the acetylcholinesterase oxime reactivators HI-6, obidoxime, and PAM to efficacy against sarin (isopropyl methylphosphonofluoridate) poisoning in rats.
    Toxicology and applied pharmacology, 1987, Jun-30, Volume: 89, Issue:2

    Topics: Acetylcholinesterase; Animals; Male; Obidoxime Chloride; Organophosphate Poisoning; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Inbred Strains; Sarin

1987
[Comparative reactivation efficacy of the oximes HI-6 and HGG-12 in the central nervous system and blood of rats poisoned with nerve gases used in warfare].
    Godisnjak Vojnomedicinske akademije = Annual of the Military Medical Academy, 1986, Volume: 28

    Topics: Acetylcholinesterase; Animals; Central Nervous System; Chemical Warfare; Cholinesterase Inhibitors; Cholinesterase Reactivators; Gas Poisoning; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats; Sarin; Soman

1986
Reactivation of nerve agent inhibited human acetylcholinesterases by HI-6 and obidoxime.
    Biochemical pharmacology, 1986, May-01, Volume: 35, Issue:9

    Topics: Acetylcholinesterase; Caudate Nucleus; Cholinesterase Reactivators; Edrophonium; Humans; Muscles; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman; Stereoisomerism

1986
Reactivation of Sarin- or Soman-phosphonylated human acetylcholinesterase by bis-pyridinium mono-oximes.
    Biochemical pharmacology, 1986, Jan-15, Volume: 35, Issue:2

    Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Reactivators; Erythrocytes; Humans; Muscles; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Sarin; Soman

1986
The efficacy of some bis-pyridinium oximes as antidotes to soman in isolated muscles of several species including man.
    European journal of pharmacology, 1981, Mar-26, Volume: 70, Issue:3

    Topics: Adult; Aged; Animals; Antidotes; Chorionic Gonadotropin; Dogs; Electric Stimulation; Female; Guinea Pigs; Humans; In Vitro Techniques; Male; Middle Aged; Neuromuscular Junction; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Sarin; Soman; Species Specificity; Synaptic Transmission

1981
Examination of the role of central cholinergic mechanisms in the therapeutic effects of HI-6 in organophosphate poisoning.
    Journal of neurochemistry, 1983, Volume: 40, Issue:5

    Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Injections, Intraventricular; Lethal Dose 50; Male; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Rats, Inbred Strains; Sarin; Soman

1983
HI-6: reactivation of central and peripheral acetylcholinesterase following inhibition by soman, sarin and tabun in vivo in the rat.
    Biochemical pharmacology, 1982, Apr-01, Volume: 31, Issue:7

    Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Organophosphates; Organophosphorus Compounds; Oximes; Peripheral Nerves; Pyridinium Compounds; Rats; Rats, Inbred Strains; Sarin; Soman

1982
Effect of atropine and bispyridinium oximes on respiratory and circulatory function in guinea-pigs poisoned by sarin.
    Toxicology, 1995, Jan-06, Volume: 95, Issue:1-3

    Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Blood Pressure; Cholinesterase Reactivators; Drug Therapy, Combination; Female; Guinea Pigs; Heart Rate; Oximes; Poisoning; Pyridines; Pyridinium Compounds; Respiration; Sarin

1995
Comparison of the therapeutic effects and pharmacokinetics of HI-6, HLö-7, HGG-12, HGG-42 and obidoxime following non-reactivatable acetylcholinesterase inhibition in rats.
    Archives of toxicology, 1994, Volume: 68, Issue:4

    Topics: Animals; Binding, Competitive; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; In Vitro Techniques; Male; Neuromuscular Junction; Obidoxime Chloride; Oximes; Pyridines; Pyridinium Compounds; Quinuclidinyl Benzilate; Rats; Sarin; Synaptic Transmission

1994
A comparison of the efficacy of HI6 and 2-PAM against soman, tabun, sarin, and VX in the rabbit.
    Toxicology letters, 1994, Feb-15, Volume: 70, Issue:3

    Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazepam; Lethal Dose 50; Male; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Rabbits; Sarin; Soman; Specific Pathogen-Free Organisms

1994
Amplification of the effectiveness of acetylcholinesterase for detoxification of organophosphorus compounds by bis-quaternary oximes.
    Biochemical pharmacology, 1994, Jan-20, Volume: 47, Issue:2

    Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Inactivation, Metabolic; Lethal Dose 50; Mice; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman

1994
Therapeutic efficacy of obidoxime or HI-6 with atropine against intoxication with some nerve agents in mice.
    Acta medica (Hradec Kralove), 1996, Volume: 39, Issue:1

    Topics: Animals; Antidotes; Chemical Warfare Agents; Cholinesterase Reactivators; Female; Gas Poisoning; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman

1996
High-level expression of human butyrylcholinesterase gene in Bombyx mori and biochemical-pharmacological characteristic study of its product.
    Biochemical pharmacology, 2000, Jul-01, Volume: 60, Issue:1

    Topics: Animals; Antibodies; Baculoviridae; Bombyx; Butyrylcholinesterase; Cells, Cultured; Cholinesterase Inhibitors; Cholinesterase Reactivators; Cloning, Molecular; Cricetinae; Drug Interactions; Gene Expression; Humans; Larva; Oximes; Pyridinium Compounds; Rabbits; Sarin

2000
Effect of human plasma on the reactivation of sarin-inhibited human erythrocyte acetylcholinesterase.
    Archives of toxicology, 2000, Volume: 74, Issue:1

    Topics: Acetylcholinesterase; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocyte Aging; Erythrocytes; Humans; In Vitro Techniques; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Sarin

2000
Reactivation kinetics of acetylcholinesterase from different species inhibited by highly toxic organophosphates.
    Archives of toxicology, 2002, Volume: 76, Issue:9

    Topics: Acetylcholinesterase; Algorithms; Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Enzyme Activation; Erythrocyte Membrane; Guinea Pigs; Humans; Kinetics; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Rabbits; Rats; Sarin; Species Specificity

2002
Effect of atropine and the oxime HI-6 on low-level sarin-induced alteration of performance of rats in a T-maze.
    Acta medica (Hradec Kralove), 2002, Volume: 45, Issue:3

    Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Maze Learning; Muscarinic Antagonists; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Sarin

2002
The impairment of spatial memory following low-level sarin inhalation exposure and antidotal treatment in rats.
    Acta medica (Hradec Kralove), 2002, Volume: 45, Issue:4

    Topics: Administration, Inhalation; Animals; Antidotes; Atropine; Male; Maze Learning; Memory; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Sarin

2002
In vitro reactivation of acetylcholinesterase using the oxime K027.
    Veterinary and human toxicology, 2004, Volume: 46, Issue:1

    Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Structure-Activity Relationship

2004
A comparison of the efficacy of a bispyridinium oxime--1,4-bis-(2-hydroxyiminomethylpyridinium) butane dibromide and currently used oximes to reactivate sarin, tabun or cyclosarin-inhibited acetylcholinesterase by in vitro methods.
    Die Pharmazie, 2004, Volume: 59, Issue:10

    Topics: Acetylcholinesterase; Animals; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar; Sarin

2004
In vitro reactivation of sarin-inhibited brain acetylcholinesterase from different species by various oximes.
    Journal of enzyme inhibition and medicinal chemistry, 2005, Volume: 20, Issue:3

    Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Humans; Kinetics; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Sarin; Species Specificity; Structure-Activity Relationship; Swine

2005
Direct reaction of oximes with crotylsarin, cyclosarin, or VX in vitro.
    Archives of toxicology, 2007, Volume: 81, Issue:6

    Topics: Cholinesterase Inhibitors; Cholinesterase Reactivators; Decontamination; Half-Life; Kinetics; Models, Chemical; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Spectrophotometry, Ultraviolet

2007
Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro.
    Drug and chemical toxicology, 2007, Volume: 30, Issue:1

    Topics: Animals; Brain; Chemical Warfare Agents; Chlorpyrifos; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar; Sarin; Soman; Tissue Extracts; Trimedoxime

2007
Reactivation of sarin-inhibited pig brain acetylcholinesterase using oxime antidotes.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2006, Volume: 2, Issue:4

    Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; In Vitro Techniques; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Research Design; Sarin; Swine

2006
Potency of novel oximes to reactivate sarin inhibited human cholinesterases.
    Drug and chemical toxicology, 2008, Volume: 31, Issue:1

    Topics: Acetylcholinesterase; Antidotes; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Humans; In Vitro Techniques; Molecular Structure; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Structure-Activity Relationship

2008
A structure-activity analysis of the variation in oxime efficacy against nerve agents.
    Toxicology and applied pharmacology, 2008, Sep-01, Volume: 231, Issue:2

    Topics: Acetylcholinesterase; Animals; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocytes; Guinea Pigs; Linear Models; Male; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Structure-Activity Relationship

2008
Interaction of pentylsarin analogues with human acetylcholinesterase: a kinetic study.
    Toxicology letters, 2009, Jun-01, Volume: 187, Issue:2

    Topics: Acetylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocyte Membrane; Humans; Kinetics; Male; Obidoxime Chloride; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin

2009
Structure of HI-6*sarin-acetylcholinesterase determined by X-ray crystallography and molecular dynamics simulation: reactivator mechanism and design.
    PloS one, 2009, Jun-18, Volume: 4, Issue:6

    Topics: Acetylcholinesterase; Animals; Catalysis; Cholinesterase Reactivators; Computer Simulation; Crystallography, X-Ray; Histidine; Humans; Hydrogen Bonding; Kinetics; Mice; Mutagenesis, Site-Directed; Oximes; Pyridinium Compounds; Sarin

2009
Kinetic analysis of interactions of different sarin and tabun analogues with human acetylcholinesterase and oximes: is there a structure-activity relationship?
    Chemico-biological interactions, 2010, Sep-06, Volume: 187, Issue:1-3

    Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Enzyme Activation; Humans; Kinetics; Obidoxime Chloride; Organophosphates; Oximes; Protein Binding; Pyridinium Compounds; Sarin; Structure-Activity Relationship

2010
The benefit of combinations of oximes for the reactivating and therapeutic efficacy of antidotal treatment of sarin poisoning in rats and mice.
    Basic & clinical pharmacology & toxicology, 2011, Volume: 109, Issue:1

    Topics: Acetylcholinesterase; Animals; Antidotes; Chemical Warfare Agents; Drug Therapy, Combination; Male; Mice; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Sarin; Trimedoxime

2011
Restoration of nerve agent inhibited muscle force production in human intercostal muscle strips with HI 6.
    Toxicology letters, 2011, Sep-25, Volume: 206, Issue:1

    Topics: Acetylcholinesterase; Aged; Chemical Warfare Agents; Cholinesterase Reactivators; Electric Stimulation; Humans; In Vitro Techniques; Intercostal Muscles; Muscle Strength; Neuromuscular Junction; Organophosphates; Oximes; Pyridinium Compounds; Sarin; Soman

2011
The benefit of combination of oximes for the neuroprotective efficacy of antidotal treatment of sarin-poisoned rats.
    Toxicology mechanisms and methods, 2012, Volume: 22, Issue:4

    Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Therapy, Combination; Male; Molecular Structure; Neuroprotective Agents; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Sarin; Trimedoxime

2012
A comparison of the potency of a novel bispyridinium oxime K203 and currently available oximes (obidoxime, HI-6) to counteract the acute neurotoxicity of sarin in rats.
    Basic & clinical pharmacology & toxicology, 2012, Volume: 111, Issue:5

    Topics: Animals; Antidotes; Atropine; Autonomic Nervous System; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Czech Republic; Drug Therapy, Combination; Lethal Dose 50; Male; Muscarinic Antagonists; Neurons; Neurotoxicity Syndromes; Obidoxime Chloride; Oximes; Psychomotor Performance; Pyridinium Compounds; Rats; Rats, Wistar; Sarin

2012
A common mechanism for resistance to oxime reactivation of acetylcholinesterase inhibited by organophosphorus compounds.
    Chemico-biological interactions, 2013, Mar-25, Volume: 203, Issue:1

    Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; GPI-Linked Proteins; Humans; Kinetics; Obidoxime Chloride; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Quantitative Structure-Activity Relationship; Recombinant Proteins; Sarin

2013
A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K727, K733) with the oxime HI-6 and obidoxime in sarin-poisoned rats and mice.
    Toxicology mechanisms and methods, 2015, Volume: 25, Issue:3

    Topics: Acetylcholinesterase; Animals; Animals, Outbred Strains; Antidotes; Atropine; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diaphragm; Dose-Response Relationship, Drug; Drug Therapy, Combination; Male; Mice; Muscarinic Antagonists; Nerve Tissue Proteins; Neurons; Neurotoxicity Syndromes; Obidoxime Chloride; Oximes; Pyridinium Compounds; Rats, Wistar; Sarin

2015
Structure of a prereaction complex between the nerve agent sarin, its biological target acetylcholinesterase, and the antidote HI-6.
    Proceedings of the National Academy of Sciences of the United States of America, 2016, May-17, Volume: 113, Issue:20

    Topics: Acetylcholinesterase; Antidotes; Cholinesterase Reactivators; Crystallography, X-Ray; Kinetics; Molecular Conformation; Nerve Agents; Oximes; Pyridinium Compounds; Sarin

2016
Reactivation of nerve agent-inhibited human acetylcholinesterase by obidoxime, HI-6 and obidoxime+HI-6: Kinetic in vitro study with simulated nerve agent toxicokinetics and oxime pharmacokinetics.
    Toxicology, 2016, 03-28, Volume: 350-352

    Topics: Acetylcholinesterase; Cholinesterase Reactivators; Drug Therapy, Combination; Humans; Inhalation Exposure; Injections, Intramuscular; Models, Biological; Nerve Agents; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Toxicokinetics

2016
A liquid chromatography tandem mass spectrometric method on in vitro nerve agents poisoning characterization and reactivator efficacy evaluation by determination of specific peptide adducts in acetylcholinesterase.
    Journal of chromatography. A, 2016, Jun-10, Volume: 1450

    Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Chromatography, Liquid; Colorimetry; Enzyme Activation; Humans; In Vitro Techniques; Nerve Agents; Obidoxime Chloride; Oximes; Peptide Fragments; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Tandem Mass Spectrometry

2016
The role of the oximes HI-6 and HS-6 inside human acetylcholinesterase inhibited with nerve agents: a computational study.
    Journal of biomolecular structure & dynamics, 2018, Volume: 36, Issue:13

    Topics: Acetylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Nerve Agents; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin

2018
Some benefit from non-oximes MB408, MB442 and MB444 in combination with the oximes HI-6 or obidoxime and atropine in antidoting sarin or cyclosarin poisoned mice.
    Toxicology, 2018, 09-01, Volume: 408

    Topics: Animals; Atropine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Lethal Dose 50; Male; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Time Factors

2018
Effect of Oxime Encapsulation on Acetylcholinesterase Reactivation: Pharmacokinetic Study of the Asoxime-Cucurbit[7]uril Complex in Mice Using Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry.
    Molecular pharmaceutics, 2021, 06-07, Volume: 18, Issue:6

    Topics: Acetylcholinesterase; Animals; Area Under Curve; Blood-Brain Barrier; Bridged-Ring Compounds; Cholinesterase Inhibitors; Cholinesterase Reactivators; Chromatography, High Pressure Liquid; Disease Models, Animal; Drug Carriers; Enzyme Assays; Humans; Hydrophobic and Hydrophilic Interactions; Imidazoles; Mass Spectrometry; Mice; Organophosphate Poisoning; Oximes; Pyridinium Compounds; Sarin

2021