asoxime chloride has been researched along with pralidoxime in 68 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (17.65) | 18.7374 |
| 1990's | 18 (26.47) | 18.2507 |
| 2000's | 23 (33.82) | 29.6817 |
| 2010's | 13 (19.12) | 24.3611 |
| 2020's | 2 (2.94) | 2.80 |
| Authors | Studies |
|---|---|
| Anderson, DR; Harris, LW; Lennox, WJ; Woodard, CL | 1 |
| Dochterman, LW; Gresham, VC; Kaminskis, A; Koplovitz, I; Stewart, JR | 1 |
| Clement, JG | 1 |
| Busker, RW; de Lange, J; Melchers, BP; van Helden, HP | 1 |
| Albuquerque, EX; Cintra, WM; Deshpande, SS; Reddy, VK; Scoble, GT | 1 |
| Shih, T; Valdes, JJ; Whalley, CE | 1 |
| Anderson, DR; Harris, LW; Lennox, WJ; Lieske, CN | 1 |
| Hayward, IJ; Lukey, B; Moore, DH; Tucker, FS | 1 |
| Baux, G; Fossier, P; Poulain, B; Tauc, L | 1 |
| Anderson, DR; Harris, LW; Lennox, WJ; Pastelak, AM; Vanderpool, BA; Woodard, CL | 1 |
| Anthony, A; Doebler, JA; Martin, LJ | 1 |
| Albuquerque, EX; Alkondon, M; Rao, KS | 1 |
| Anderson, DR; Harris, LW; Lennox, WJ; Talbot, BG | 1 |
| Grubic, Z; Tomazic, A | 1 |
| Clement, JG; Shiloff, JD | 1 |
| Bokonjić, D; Jokanović, M; Jovanović, D; Maksimović, M | 1 |
| Anderson, DR; Green, MD; Harris, LW; Lennox, WJ; Talbot, BG | 1 |
| Chou, TC; Li, FZ; Sun, MC | 1 |
| Bedford, CD; Howd, RA; Jackson, SE; Kenley, RA | 1 |
| Dawson, RM; Poretski, M | 1 |
| Bosković, B; Cetković, S; Cosić, M; Cvetković, M; Jandrić, D | 1 |
| Bosković, B; Jovanović, D; Kovacević, V | 1 |
| Koplovitz, I; Young, GD | 1 |
| Koplovitz, I; Stewart, JR | 1 |
| Doctor, BP; Genovese, RF | 1 |
| Baubichon, D; Blanchet, G; Brochier, G; Clarencon, D; Galonnier, M; Lallement, G; Mestries, JC | 1 |
| Knopff, O; Szinicz, L; Widmann, R; Worek, F | 1 |
| Diepold, C; Eyer, P; Worek, F | 1 |
| Ashani, Y; Doctor, BP; Leader, H; Luo, C; Radić, Z; Saxena, A; Taylor, P | 1 |
| Chen, W; Chunli, B; Delu, Z; Yingge, Z | 1 |
| Berman, HA; Brüggemann, RJ; Hosea, N; Radic, Z; Taylor, P; Wong, L | 1 |
| Eyer, P; Kiderlen, D; Szinicz, L; Thiermann, H; Worek, F | 1 |
| Eyer, P; Reiter, G; Szinicz, L; Worek, F | 1 |
| Kassa, J; Krejèová, G | 1 |
| Szinicz, L; Thiermann, H; Worek, F | 1 |
| Kassa, J; Kuca, K | 1 |
| Berman, HA; Kovarik, Z; Radić, Z; Reiner, E; Simeon-Rudolf, V; Taylor, P | 1 |
| Cabal, J; Kassa, J; Kuca, K | 2 |
| Aas, P; Tansø, R; Øydvin, OK | 1 |
| Go, ML; Loke, WK; Sim, MK | 1 |
| Cabal, J; Hrabinová, M; Jun, D; Kassa, J; Kuca, K | 2 |
| Becker, G; Gutzeit, D; Kawan, A; Szinicz, L; Worek, F | 1 |
| Bajgar, J; Cabal, J; Hrabinova, M; Jun, D; Kuca, K | 1 |
| Bajgar, J; Jun, D; Kuca, K | 1 |
| Cabal, J; Jun, D; Kuca, K; Musilek, K | 1 |
| Jun, D; Kuca, K | 1 |
| Jun, D; Koleckar, V; Kuca, K; Marek, J; Picha, J | 1 |
| Koplovitz, I; Maxwell, DM; Sweeney, RE; Worek, F | 1 |
| Jun, D; Kuca, K; Pohanka, M | 1 |
| Aurbek, N; Eyer, F; Eyer, P; Thiermann, H; Worek, F | 1 |
| Hasan, MY; Kuca, K; Lorke, DE; Nurulain, SM; Petroianu, GA; Schmitt, A | 1 |
| Eyer, P; Thiermann, H; Worek, F | 1 |
| Bohnert, S; Mikler, J; Vair, C | 1 |
| Aurbek, N; Eyer, P; Thiermann, H; Wille, T; Worek, F | 1 |
| Fišar, Z; Hroudová, J; Korábečný, J; Kuča, K; Musílek, K | 1 |
| Hrabinova, M; Kuca, K; Pohanka, M; Simonato, JP | 1 |
| Arboléas, M; Baati, R; Gillon, E; Jean, L; Kliachyna, M; Loiodice, M; Mercey, G; Nachon, F; Păunescu, E; Renard, PY; Renou, J; Verdelet, T | 1 |
| Elsinghorst, P; Koller, M; Thiermann, H; Worek, F | 1 |
| Chambers, C; Luo, C; Saxena, A; Tong, M; Yang, Y | 1 |
| Arboléas, M; Calas, AG; Dias, J; Jean, L; Mercey, G; Nachon, F; Renard, PY; Rousseau, C; Touvrey-Loiodice, M | 1 |
| Chen, J; Guo, L; Tang, J; Xie, J; Xie, Y; Xu, B; Yan, L | 1 |
| Antonijevic, B; Antonijevic, E; Djukic-Cosic, D; Kosvancova, A; Kotur-Stevuljevic, J; Kuca, K; Musilek, K; Spasojevic-Kalimanovska, V | 1 |
| Castellarin, C; Chaussard, H; Denis, J; Dhote, F; Dorandeu, F; Jaffré, N; Menneteau, M; Reymond, C; Taudon, N | 1 |
| Hepnarova, V; Herman, D; Hrabinova, M; Jun, D; Misik, J; Muckova, L; Pejchal, J; Ring, A; Soukup, O | 1 |
| John, H; Kranawetvogl, T; Steinritz, D; Thiermann, H | 1 |
| Caisberger, F; Hatlapatková, J; Hepnarová, V; Kassa, J; Pejchal, J; Žďárová Karasová, J | 1 |
1 review(s) available for asoxime chloride and pralidoxime
| Article | Year |
|---|---|
Role of edrophonium in prevention of the re-inhibition of acetylcholinesterase by phosphorylated oxime.
Topics: Animals; Antidotes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Edrophonium; Kinetics; Mice; Obidoxime Chloride; Oximes; Phosphorylation; Pralidoxime Compounds; Pyridinium Compounds | 1999 |
67 other study(ies) available for asoxime chloride and pralidoxime
| Article | Year |
|---|---|
The effect of pyridostigmine pretreatment on oxime efficacy against intoxication by soman or VX in rats.
Topics: Animals; Antidotes; Cholinesterase Inhibitors; Male; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Rats; Rats, Sprague-Dawley; Soman | 1992 |
Evaluation of the toxicity, pathology, and treatment of cyclohexylmethylphosphonofluoridate (CMPF) poisoning in rhesus monkeys.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Lethal Dose 50; Macaca mulatta; Male; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide | 1992 |
Efficacy of various oximes against GF (cyclohexyl methylphosphonofluoridate) poisoning in mice.
Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Reactivators; In Vitro Techniques; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Nervous System Diseases; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds | 1992 |
Therapy of organophosphate poisoning in the rat by direct effects of oximes unrelated to ChE reactivation.
Topics: Animals; Antidotes; Blood-Brain Barrier; Cholinesterase Reactivators; Diaphragm; In Vitro Techniques; Male; Neuromuscular Junction; Obidoxime Chloride; Organophosphate Poisoning; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Respiratory Insufficiency; Synaptic Transmission | 1991 |
Effectiveness of oximes 2-PAM and HI-6 in recovery of muscle function depressed by organophosphate agents in the rat hemidiaphragm: an in vitro study.
Topics: Animals; Cholinesterase Reactivators; Diaphragm; Electric Stimulation; Female; In Vitro Techniques; Muscle Contraction; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Inbred Strains; Respiratory Muscles | 1991 |
A comparison of cholinergic effects of HI-6 and pralidoxime-2-chloride (2-PAM) in soman poisoning.
Topics: Acetylcholinesterase; Animals; Atropine; Brain; Cholinesterase Reactivators; Cholinesterases; Drug Interactions; Lethal Dose 50; Male; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Soman | 1991 |
Evaluation of phosphinates as potential pretreatments for nerve agents.
Topics: Acetylcholinesterase; Animals; Atropine; Cholinesterase Reactivators; Evaluation Studies as Topic; Guinea Pigs; Injections, Intramuscular; Lethal Dose 50; Male; Nitrobenzenes; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds | 1991 |
HI-6 and 2-PAM in sheep: pharmacokinetics and effects on muscle tissue following intramuscular injection.
Topics: Animals; Cholinesterase Reactivators; Creatine Kinase; Half-Life; Injections, Intramuscular; Irritants; Isoenzymes; Muscles; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sheep | 1991 |
Receptor-mediated presynaptic facilitation of quantal release of acetylcholine induced by pralidoxime in Aplysia.
Topics: Acetylcholine; Acetylcholinesterase; Action Potentials; Animals; Aplysia; Atropine; Enzyme Activation; Hemicholinium 3; Neurons; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Receptors, Nicotinic; Secretory Rate; Synapses; Tubocurarine | 1990 |
Evaluation of several oximes as reactivators of unaged soman-inhibited whole blood acetylcholinesterase in rabbits.
Topics: Acetylcholinesterase; Animals; Cerebral Cortex; Cholinesterase Inhibitors; Diaphragm; Dose-Response Relationship, Drug; Imidazoles; Medulla Oblongata; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rabbits; Soman; Time Factors | 1990 |
Effects of HI-6 and pralidoxime on neuronal RNA in thalamic cholinergic sites.
Topics: Animals; Antidotes; Cholinesterase Reactivators; Cholinesterases; Corpus Striatum; Male; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Inbred Strains; RNA; Soman; Thalamic Nuclei | 1985 |
Acetylcholinesterase reactivators modify the functional properties of the nicotinic acetylcholine receptor ion channel.
Topics: Acetylcholinesterase; Acetylthiocholine; Animals; Cholinesterase Reactivators; In Vitro Techniques; Ion Channels; Kinetics; Membrane Potentials; Muscle Denervation; Muscles; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rana pipiens; Receptors, Nicotinic | 1988 |
The relationship between oxime-induced reactivation of carbamylated acetylcholinesterase and antidotal efficacy against carbamate intoxication.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Carbaryl; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Interactions; Erythrocytes; Lethal Dose 50; Male; Oximes; Physostigmine; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Inbred Strains | 1989 |
Mechanism of action of HI-6 on soman inhibition of acetylcholinesterase in preparations of rat and human skeletal muscle; comparison to SAD-128 and PAM-2.
Topics: Acetylcholinesterase; Animals; Antidotes; Cholinesterase Inhibitors; Female; Humans; In Vitro Techniques; Muscles; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Inbred Strains; Soman | 1989 |
Comparison of serum concentrations of the acetylcholinesterase oxime reactivators HI-6, obidoxime, and PAM to efficacy against sarin (isopropyl methylphosphonofluoridate) poisoning in rats.
Topics: Acetylcholinesterase; Animals; Male; Obidoxime Chloride; Organophosphate Poisoning; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Inbred Strains; Sarin | 1987 |
Protective effects of oximes HI-6 and PAM-2 applied by osmotic minipumps in quinalphos-poisoned rats.
Topics: Animals; Antidotes; Atropine; Brain; Cholinesterase Reactivators; Cholinesterases; Diazepam; Insecticides; Lethal Dose 50; Male; Muscles; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats | 1987 |
Oxime-induced decarbamylation and atropine/oxime therapy of guinea pigs intoxicated with pyridostigmine.
Topics: Acetylcholinesterase; Animals; Atropine; Erythrocytes; Guinea Pigs; Male; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide | 1987 |
Reactivation of Sarin- or Soman-phosphonylated human acetylcholinesterase by bis-pyridinium mono-oximes.
Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Reactivators; Erythrocytes; Humans; Muscles; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Sarin; Soman | 1986 |
Reactivation of ethyl methylphosphonylated eel acetylcholinesterase in vitro by 2PAM, H16, and a series of nonquaternary alpha-ketothiohydroximates.
Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Eels; Hydroxamic Acids; Kinetics; Oximes; Pralidoxime Compounds; Pyridinium Compounds | 1985 |
Carbamylated acetylcholinesterase: acceleration of decarbamylation by bispyridinium oximes.
Topics: Acetylcholinesterase; Animals; Brain; Carbamates; Cattle; Erythrocytes; Humans; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rabbits; Trimedoxime | 1985 |
Effect of PAM-2 Cl, HI-6, and HGG-12 in poisoning by tabun and its thiocholine-like analog in the rat.
Topics: Animals; Atropine; Choline; Cholinesterase Reactivators; Cholinesterases; Female; Guinea Pigs; Heart; Humans; Lethal Dose 50; Male; Muscle Contraction; Muscle, Smooth; Organophosphate Poisoning; Organophosphates; Oximes; Phrenic Nerve; Pralidoxime Compounds; Pyridinium Compounds; Rats; Thiocholine | 1984 |
PAM-2 Cl, HI-6, and HGG-12 in soman and tabun poisoning.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazepam; Dogs; Guinea Pigs; Lethal Dose 50; Male; Mice; Organophosphate Poisoning; Organophosphates; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Soman; Species Specificity | 1984 |
Acute toxicity of cyclohexylmethylphosphonofluoridate (CMPF) in rhesus monkeys: serum biochemical and hematologic changes.
Topics: Alanine Transaminase; Animals; Antidotes; Aspartate Aminotransferases; Atropine; Biomarkers; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Creatine Kinase; Injections, Intramuscular; L-Lactate Dehydrogenase; Lethal Dose 50; Macaca mulatta; Male; Organophosphorus Compounds; Oximes; Potassium; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Seizures | 1995 |
A comparison of the efficacy of HI6 and 2-PAM against soman, tabun, sarin, and VX in the rabbit.
Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazepam; Lethal Dose 50; Male; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Rabbits; Sarin; Soman; Specific Pathogen-Free Organisms | 1994 |
Behavioral comparison of the oximes TMB-4, 2-PAM, and HI-6 in rats using operant conditioning.
Topics: Animals; Behavior, Animal; Cholinesterase Inhibitors; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Trimedoxime | 1997 |
Efficacy of atropine/pralidoxime/diazepam or atropine/HI-6/prodiazepam in primates intoxicated by soman.
Topics: Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Diazepam; Dipeptides; Drug Therapy, Combination; Electrocardiography; Electroencephalography; Macaca fascicularis; Male; Oximes; Poisoning; Pralidoxime Compounds; Prodrugs; Pyridinium Compounds; Soman | 1997 |
Reactivating potency of obidoxime, pralidoxime, HI 6 and HLö 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds.
Topics: Acetylcholinesterase; Antidotes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocytes; Humans; Obidoxime Chloride; Organophosphates; Oximes; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Soman | 1998 |
Dimethylphosphoryl-inhibited human cholinesterases: inhibition, reactivation, and aging kinetics.
Topics: Acetylcholinesterase; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Cholinesterases; Humans; Insecticides; Kinetics; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Paraoxon; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Time Factors | 1999 |
Force spectroscopy between acetylcholinesterase molecule and its natural substrate to study the effects of inhibitors and reactivators on enzyme activity.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Enzymes, Immobilized; Kinetics; Microscopy, Atomic Force; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Torpedo | 1999 |
Mechanism of oxime reactivation of acetylcholinesterase analyzed by chirality and mutagenesis.
Topics: Acetylcholinesterase; Animals; Cell Line; Cholinesterase Inhibitors; Cholinesterase Reactivators; Humans; Kinetics; Mice; Mutagenesis, Site-Directed; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Protein Conformation; Pyridinium Compounds; Stereoisomerism; Thiocholine; Transfection | 2000 |
Effect of human plasma on the reactivation of sarin-inhibited human erythrocyte acetylcholinesterase.
Topics: Acetylcholinesterase; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocyte Aging; Erythrocytes; Humans; In Vitro Techniques; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Sarin | 2000 |
Reactivation kinetics of acetylcholinesterase from different species inhibited by highly toxic organophosphates.
Topics: Acetylcholinesterase; Algorithms; Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Enzyme Activation; Erythrocyte Membrane; Guinea Pigs; Humans; Kinetics; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Rabbits; Rats; Sarin; Species Specificity | 2002 |
Neuroprotective effects of currently used antidotes in tabun-poisoned rats.
Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Reactivators; Drug Therapy, Combination; Male; Motor Activity; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar | 2003 |
Reactivation and aging kinetics of human acetylcholinesterase inhibited by organophosphonylcholines.
Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocyte Membrane; Humans; Obidoxime Chloride; Organophosphorus Compounds; Oximes; Phosphorylcholine; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Spectrophotometry; Time Factors | 2004 |
In vitro reactivation of acetylcholinesterase using the oxime K027.
Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Structure-Activity Relationship | 2004 |
Mutant cholinesterases possessing enhanced capacity for reactivation of their phosphonylated conjugates.
Topics: Acetylcholinesterase; Alanine; Amino Acid Substitution; Animals; Butyrylcholinesterase; Cholinesterase Reactivators; Computer Simulation; Kinetics; Mice; Models, Molecular; Mutation; Organophosphonates; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Structure-Activity Relationship; Tyrosine | 2004 |
A comparison of the efficacy of a bispyridinium oxime--1,4-bis-(2-hydroxyiminomethylpyridinium) butane dibromide and currently used oximes to reactivate sarin, tabun or cyclosarin-inhibited acetylcholinesterase by in vitro methods.
Topics: Acetylcholinesterase; Animals; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar; Sarin | 2004 |
Pre-junctional effects of oximes on [3H]-acetylcholine release in rat hippocampal slices during soman intoxication.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Hippocampus; In Vitro Techniques; Male; Neuromuscular Junction; Obidoxime Chloride; Oximes; Potassium; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Rats; Rats, Wistar; Soman; Tritium | 2005 |
In vitro reactivation of sarin-inhibited brain acetylcholinesterase from different species by various oximes.
Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Humans; Kinetics; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Sarin; Species Specificity; Structure-Activity Relationship; Swine | 2005 |
Novel neuroprotective effects with O-benzyl derivative of pralidoxime in soman-intoxicated rodents.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcholine; Analysis of Variance; Animals; Anticonvulsants; Atropine; Benzene Derivatives; Cholinesterase Inhibitors; Cholinesterase Reactivators; Corpus Striatum; Dopamine; Drug Synergism; Electroencephalography; Female; Homovanillic Acid; Hydroxyindoleacetic Acid; Mice; Microdialysis; Neuroprotective Agents; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar; Seizures; Serotonin; Soman; Survival Rate; Time Factors | 2005 |
A comparison of the potency of the oxime HLö-7 and currently used oximes (HI-6, pralidoxime, obidoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods.
Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; In Vitro Techniques; Male; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar | 2005 |
In vitro potency of H oximes (HI-6, HLö-7), the oxime BI-6, and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase.
Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Rats; Rats, Wistar; Trimedoxime | 2006 |
Direct reaction of oximes with crotylsarin, cyclosarin, or VX in vitro.
Topics: Cholinesterase Inhibitors; Cholinesterase Reactivators; Decontamination; Half-Life; Kinetics; Models, Chemical; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Spectrophotometry, Ultraviolet | 2007 |
Potency of new structurally different oximes to reactivate cyclosarin-inhibited human brain acetylcholinesterases.
Topics: Acetylcholinesterase; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Humans; Kinetics; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds | 2006 |
Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro.
Topics: Animals; Brain; Chemical Warfare Agents; Chlorpyrifos; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar; Sarin; Soman; Tissue Extracts; Trimedoxime | 2007 |
In vitro reactivation potency of acetylcholinesterase reactivators--K074 and K075--to reactivate tabun-inhibited human brain cholinesterases.
Topics: Acetylcholinesterase; Butanes; Caudate Nucleus; Cholinesterase Inhibitors; Cholinesterase Reactivators; Enzyme Activation; Humans; In Vitro Techniques; Obidoxime Chloride; Organophosphates; Oximes; Pralidoxime Compounds; Pyridinium Compounds | 2007 |
Reactivation of sarin-inhibited pig brain acetylcholinesterase using oxime antidotes.
Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; In Vitro Techniques; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Research Design; Sarin; Swine | 2006 |
Potency of novel oximes to reactivate sarin inhibited human cholinesterases.
Topics: Acetylcholinesterase; Antidotes; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Humans; In Vitro Techniques; Molecular Structure; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Structure-Activity Relationship | 2008 |
A structure-activity analysis of the variation in oxime efficacy against nerve agents.
Topics: Acetylcholinesterase; Animals; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocytes; Guinea Pigs; Linear Models; Male; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Structure-Activity Relationship | 2008 |
In vitro reactivation of trichlorfon-inhibited butyrylcholinesterase using HI-6, obidoxime, pralidoxime and K048.
Topics: Acetylcholinesterase; Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Humans; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Trichlorfon | 2009 |
Suitability of human butyrylcholinesterase as therapeutic marker and pseudo catalytic scavenger in organophosphate poisoning: a kinetic analysis.
Topics: Acetylcholinesterase; Biomarkers; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocyte Membrane; Humans; Kinetics; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pesticides; Pralidoxime Compounds; Pyridinium Compounds | 2009 |
Efficacy of two new asymmetric bispyridinium oximes (K-27 and K-48) in rats exposed to diisopropylfluorophosphate: comparison with pralidoxime, obidoxime, trimedoxime, methoxime, and HI-6.
Topics: Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Isoflurophate; Male; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar; Trimedoxime | 2009 |
Muscle force and acetylcholinesterase activity in mouse hemidiaphragms exposed to paraoxon and treated by oximes in vitro.
Topics: Acetylcholinesterase; Animals; Diaphragm; Humans; Male; Mice; Mice, Inbred Strains; Obidoxime Chloride; Oximes; Paraoxon; Physical Phenomena; Pralidoxime Compounds; Pyridinium Compounds | 2010 |
Development and validation of a sensitive HPLC method for the quantification of HI-6 in guinea pig plasma and evaluated in domestic swine.
Topics: Animals; Cholinesterase Reactivators; Chromatography, High Pressure Liquid; Drug Stability; Guinea Pigs; Linear Models; Male; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Reproducibility of Results; Sensitivity and Specificity; Swine | 2010 |
Kinetic analysis of interactions of paraoxon and oximes with human, Rhesus monkey, swine, rabbit, rat and guinea pig acetylcholinesterase.
Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Drug Interactions; Enzyme Reactivators; Guinea Pigs; Humans; Kinetics; Macaca mulatta; Obidoxime Chloride; Oximes; Paraoxon; Pralidoxime Compounds; Pyridinium Compounds; Rabbits; Rats; Rats, Wistar; Species Specificity; Swine | 2011 |
In vitro effects of acetylcholinesterase reactivators on monoamine oxidase activity.
Topics: Animals; Brain; Cholinesterase Reactivators; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Swine; Trimedoxime | 2011 |
Assessment of acetylcholinesterase activity using indoxylacetate and comparison with the standard Ellman's method.
Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dithionitrobenzoic Acid; Enzyme Assays; Indoles; Kinetics; Obidoxime Chloride; Oximes; Paraoxon; Pralidoxime Compounds; Pyridinium Compounds; Substrate Specificity | 2011 |
Syntheses and in vitro evaluations of uncharged reactivators for human acetylcholinesterase inhibited by organophosphorus nerve agents.
Topics: Acetylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Evaluation, Preclinical; Electrochemistry; GPI-Linked Proteins; Humans; Molecular Structure; Obidoxime Chloride; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Recombinant Proteins | 2013 |
Reactions of methylphosphonic difluoride with human acetylcholinesterase and oximes--Possible therapeutic implications.
Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; GPI-Linked Proteins; Humans; Obidoxime Chloride; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Time Factors | 2014 |
Probing the role of amino acids in oxime-mediated reactivation of nerve agent-inhibited human acetylcholinesterase.
Topics: Acetylcholinesterase; Amino Acids; Animals; Cattle; Chemical Warfare Agents; CHO Cells; Cholinesterase Reactivators; Cricetulus; Humans; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds | 2015 |
An easy method for the determination of active concentrations of cholinesterase reactivators in blood samples: Application to the efficacy assessment of non quaternary reactivators compared to HI-6 and pralidoxime in VX-poisoned mice.
Topics: Acetylcholinesterase; Animals; Blood Chemical Analysis; Blood-Brain Barrier; Chemical Warfare Agents; Cholinesterase Reactivators; Erythrocytes; Half-Life; Humans; Injections, Intraperitoneal; Male; Mice; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Protective Agents; Pyridinium Compounds | 2017 |
A liquid chromatography tandem mass spectrometric method on in vitro nerve agents poisoning characterization and reactivator efficacy evaluation by determination of specific peptide adducts in acetylcholinesterase.
Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Chromatography, Liquid; Colorimetry; Enzyme Activation; Humans; In Vitro Techniques; Nerve Agents; Obidoxime Chloride; Oximes; Peptide Fragments; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Tandem Mass Spectrometry | 2016 |
Effect of six oximes on acutely anticholinesterase inhibitor-induced oxidative stress in rat plasma and brain.
Topics: Animals; Aryldialkylphosphatase; Biomarkers; Brain; Cholinesterase Inhibitors; Dichlorvos; Male; Malondialdehyde; Obidoxime Chloride; Organophosphate Poisoning; Oxidative Stress; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Superoxide Dismutase; Trimedoxime | 2018 |
Superior efficacy of HI-6 dimethanesulfonate over pralidoxime methylsulfate against Russian VX poisoning in cynomolgus monkeys (Macaca fascicularis).
Topics: Animals; Blood Gas Analysis; Body Temperature; Cholinesterase Inhibitors; Cholinesterase Reactivators; Cholinesterases; Heart Rate; Lethal Dose 50; Macaca fascicularis; Male; Motor Activity; Mydriasis; Nerve Agents; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Survival Rate | 2018 |
Pharmacological and toxicological in vitro and in vivo effect of higher doses of oxime reactivators.
Topics: Animals; Cell Line, Tumor; Cell Survival; Chickens; CHO Cells; Cholinesterase Reactivators; Cricetinae; Cricetulus; Female; Humans; Male; Maximum Tolerated Dose; Mice; Mice, Inbred BALB C; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds | 2019 |
A novel high-performance liquid chromatography with diode array detector method for the simultaneous quantification of the enzyme-reactivating oximes obidoxime, pralidoxime, and HI-6 in human plasma.
Topics: Cholinesterase Reactivators; Chromatography, High Pressure Liquid; Humans; Male; Obidoxime Chloride; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Reproducibility of Results | 2020 |
A Comparison of the Neuroprotective and Reactivating Efficacy of a Novel Bispyridinium Oxime K870 with Commonly Used Pralidoxime and the Oxime HI-6 in Tabun-Poisoned Rats.
Topics: Acetylcholinesterase; Animals; Antidotes; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Organophosphates; Oximes; Poisons; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar | 2021 |