asimadoline has been researched along with u-50488 in 4 studies
| Studies (asimadoline) | Trials (asimadoline) | Recent Studies (post-2010) (asimadoline) | Studies (u-50488) | Trials (u-50488) | Recent Studies (post-2010) (u-50488) |
|---|---|---|---|---|---|
| 43 | 9 | 11 | 1,664 | 3 | 209 |
| Protein | Taxonomy | asimadoline (IC50) | u-50488 (IC50) |
|---|---|---|---|
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 2.15 | |
| Kappa-type opioid receptor | Mus musculus (house mouse) | 0.0027 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 2.15 | |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.7171 | |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.0958 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 0.0537 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Carrupt, PA; Crivori, P; Cruciani, G; Testa, B | 1 |
| Binder, W; Carmody, J; Walker, J | 1 |
| Bielefeldt, K; Gebhart, GF; Joshi, SK; Lamb, K | 1 |
| Cai, Y; Chai, H; Du, C; Du, X; Duan, Y; Lv, J; Wei, W; Xie, X; Zhu, J | 1 |
4 other study(ies) available for asimadoline and u-50488
| Article | Year |
|---|---|
Predicting blood-brain barrier permeation from three-dimensional molecular structure.
Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Effect of gender on anti-inflammatory and analgesic actions of two kappa-opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetamides; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Arthritis; Arthritis, Experimental; Female; Hot Temperature; Male; Narcotics; Pain Measurement; Physical Stimulation; Pyrrolidines; Rats; Sex Characteristics; Substance P; Time Factors | 2000 |
Arylacetamide kappa-opioid receptor agonists produce a tonic- and use-dependent block of tetrodotoxin-sensitive and -resistant sodium currents in colon sensory neurons.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetamides; Analgesia; Animals; Colon; Drug Interactions; Male; Neurons, Afferent; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin | 2003 |
Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetamides; Animals; Cell Differentiation; Encephalomyelitis, Autoimmune, Experimental; Gene Deletion; Mice, Inbred C57BL; Mice, Knockout; Myelin Sheath; Oligodendroglia; Pyrrolidines; Receptors, Opioid, kappa | 2016 |