asimadoline has been researched along with naloxone in 5 studies
| Studies (asimadoline) | Trials (asimadoline) | Recent Studies (post-2010) (asimadoline) | Studies (naloxone) | Trials (naloxone) | Recent Studies (post-2010) (naloxone) |
|---|---|---|---|---|---|
| 43 | 9 | 11 | 20,134 | 1,257 | 3,321 |
| Protein | Taxonomy | asimadoline (IC50) | naloxone (IC50) |
|---|---|---|---|
| Cytochrome P450 2D6 | Homo sapiens (human) | 2 | |
| Delta-type opioid receptor | Mus musculus (house mouse) | 0.043 | |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0219 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0019 | |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0019 | |
| Mu-type opioid receptor | Homo sapiens (human) | 0.0397 | |
| Delta-type opioid receptor | Homo sapiens (human) | 0.1896 | |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.05 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 0.0795 | |
| Mu-type opioid receptor | Mus musculus (house mouse) | 0.0154 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.0089 | |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | 0.0055 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Binder, W; Walker, JS | 1 |
| Gebhart, GF; Sengupta, JN; Snider, A; Su, X | 1 |
| Gebhart, GF; Julia, V; Su, X | 1 |
| Gebhart, GF; Ozaki, N; Sengupta, JN | 1 |
| Ambriz-Tututi, M; Araiza-Saldaña, CI; Arreola-Espino, R; Bartoszyk, GD; Caram-Salas, NL; Cruz, SL; Granados-Soto, V; Reyes-García, G; Rocha-González, HI | 1 |
5 other study(ies) available for asimadoline and naloxone
| Article | Year |
|---|---|
Effect of the peripherally selective kappa-opioid agonist, asimadoline, on adjuvant arthritis.
Topics: Acetamides; Administration, Oral; Analgesics, Opioid; Animals; Arthritis, Experimental; Benzomorphans; Dose-Response Relationship, Drug; Male; Motor Activity; Naloxone; Narcotic Antagonists; Pain Measurement; Pyrrolidines; Quaternary Ammonium Compounds; Rats; Rats, Inbred Lew; Receptors, Opioid, kappa; Time Factors | 1998 |
Effects of kappa opioids in the inflamed rat colon.
Topics: Acetamides; Action Potentials; Analgesics, Opioid; Animals; Benzamides; Chronic Disease; Colitis; Colon; Electrophysiology; Male; Morphine; Naloxone; Narcotic Antagonists; Nerve Fibers; Neurons, Afferent; Pain Measurement; Piperazines; Pressure; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Rectum; Trinitrobenzenesulfonic Acid | 1999 |
Effects of intracolonic opioid receptor agonists on polymodal pelvic nerve afferent fibers in the rat.
Topics: Acetamides; Analgesics; Analgesics, Opioid; Animals; Benzamides; Colon; Fentanyl; Hot Temperature; Male; Naloxone; Narcotic Antagonists; Nerve Fibers; Neurons, Afferent; Peripheral Nerves; Physical Stimulation; Piperazines; Pressure; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Spinal Nerve Roots | 2000 |
Differential effects of mu-, delta-, and kappa-opioid receptor agonists on mechanosensitive gastric vagal afferent fibers in the rat.
Topics: Acetamides; Analgesics; Analgesics, Opioid; Animals; Benzamides; Catheterization; Electric Stimulation; Male; Mechanoreceptors; Morphine; Naloxone; Narcotic Antagonists; Nerve Fibers; Neurons, Afferent; Pain; Piperazines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stomach; Vagus Nerve | 2000 |
Subcutaneous, intrathecal and periaqueductal grey administration of asimadoline and ICI-204448 reduces tactile allodynia in the rat.
Topics: Acetamides; Animals; Dose-Response Relationship, Drug; Female; Injections, Spinal; Injections, Subcutaneous; Ligation; Lumbosacral Plexus; Male; Naloxone; Pain Threshold; Periaqueductal Gray; Peripheral Nervous System Diseases; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Somatosensory Disorders; Time Factors | 2007 |