asialo-gm1-ganglioside and globotriose

asialo-gm1-ganglioside has been researched along with globotriose* in 1 studies

Other Studies

1 other study(ies) available for asialo-gm1-ganglioside and globotriose

ArticleYear
The synthesis of 16-mercaptohexadecanyl glycosides for biosensor applications.
    Carbohydrate research, 1998, Volume: 307, Issue:3-4

    The Pk trisaccharide and the central disaccharide element of asialo GM1 activated as their trichloroacetimidates were each used to glycosylate 16-(p-toluensulfonyloxy) hexadecanol 1. Displacement of the tosyl group by thiocyanate followed by sodium borohydride reduction and saponification afforded oligosaccharide 16-mercaptohexadecanyl glycosides that were isolated as the corresponding disulfides 6 and 17 unless oxygen was rigorously excluded from the solvents used for work-up. Dithiothreitol reduction of disulfides and subsequent isolation under an inert atmosphere with degassed solvents gave the thiols 7 and 18. Chemisorption of omega-glycosyl alkanethiols and alkanethiols onto gold electrodes produces self-assembled monolayers that can act as amperometric biosensors for the detection of proteins that bind to the immobilized oligosaccharide epitope.

    Topics: Biosensing Techniques; Carbohydrate Sequence; Disaccharides; G(M1) Ganglioside; Glycosides; Glycosylation; Molecular Sequence Data; Sulfhydryl Compounds; Trisaccharides

1998