Compounds > asi-222

Page last updated: 2024-09-03

asi-222 and digitoxigenin

asi-222 has been researched along with digitoxigenin in 14 studies

Compound Research Comparison

Studies (asi-222)	Trials (asi-222)	Recent Studies (post-2010) (asi-222)	Studies (digitoxigenin)	Trials (digitoxigenin)	Recent Studies (post-2010) (digitoxigenin)
16	0	1	319	1	46

Protein Interaction Comparison

Protein	Taxonomy	asi-222 (IC50)	digitoxigenin (IC50)
Sodium/potassium-transporting ATPase subunit alpha-1	Homo sapiens (human)		0.1673
Sodium/potassium-transporting ATPase subunit beta-1	Homo sapiens (human)		0.1673
Sodium/potassium-transporting ATPase subunit alpha-3	Homo sapiens (human)		0.1673
Sodium/potassium-transporting ATPase subunit beta-2	Homo sapiens (human)		0.1673
Sodium/potassium-transporting ATPase subunit alpha-2	Homo sapiens (human)		0.1673
Sodium/potassium-transporting ATPase subunit alpha-1	Canis lupus familiaris (dog)		0.5
Potassium-transporting ATPase alpha chain 2	Homo sapiens (human)		0.08
Sodium/potassium-transporting ATPase subunit beta-3	Homo sapiens (human)		0.1673
Sodium/potassium-transporting ATPase subunit gamma	Homo sapiens (human)		0.1673
Sodium/potassium-transporting ATPase subunit alpha-4	Homo sapiens (human)		0.1673

Research

Studies (14)

Timeframe	Studies, this research(%)	All Research%
pre-1990	9 (64.29)	18.7374
1990's	4 (28.57)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	1 (7.14)	2.80

Authors

Authors	Studies
Greenblatt, DJ; Lloyd, BL; Mudge, GH; Smith, TW	1
Caldwell, RW; Cook, LS; Nash, CB	1
Caldwell, RW; Nash, CB	2
Caldwell, RW; Rebagay, WR	3
Caldwell, RW; Gunter, JL; Songu-Mize, E	1
Kuhlman, JE; Smith, TW; Somberg, JC	1
Caldwell, RW; Elam, JT; Nash, CB; Songu-Mize, E	1
Caldwell, RW; Cook, LS; Doherty, JE; Nash, CB; Straub, KD	1
Caldwell, RW; Kauker, ML; Nash, CB	1
Caldwell, RW; Gallagher, JD; Heerdt, PM	1
Chen, J; Li, H; Peng, Q; Tang, Z; Wang, Y	1

Reviews

1 review(s) available for asi-222 and digitoxigenin

Article	Year
Oral submucous fibrosis in Asian countries. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2020, Volume: 49, Issue:4 Topics: Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Digitoxigenin; Humans; Mouth Neoplasms; Oral Submucous Fibrosis	2020

Other Studies

13 other study(ies) available for asi-222 and digitoxigenin

Article	Year
Inotropic and toxic effects of a polar cardiac glycoside derivative in the dog. Circulation research, 1978, Volume: 43, Issue:6 Topics: Aminoglycosides; Animals; Blood-Brain Barrier; Brain; Digitoxigenin; Digoxin; Dogs; Dose-Response Relationship, Drug; Heart Conduction System; Injections, Intravenous; Male; Methods; Myocardial Contraction; Radioimmunoassay	1978
Comparison of the cardiac effects of ASI-222 HCl, an aminosugar cardiac glycoside, and digoxin. Archives internationales de pharmacodynamie et de therapie, 1977, Volume: 227, Issue:2 Topics: Aminoglycosides; Animals; Blood Pressure; Cardiac Output; Central Venous Pressure; Digitalis Glycosides; Digitoxigenin; Digoxin; Dogs; Female; Heart; Heart Rate; In Vitro Techniques; Male; Myocardial Contraction; Rabbits; Time Factors; Vagotomy	1977
Pharmacological studies of a new 4-aminosugar cardiac glycoside (ASI-222). The Journal of pharmacology and experimental therapeutics, 1976, Volume: 197, Issue:1 Topics: Aminoglycosides; Animals; Cardanolides; Cardiac Glycosides; Digitoxigenin; Heart Atria; Heart Rate; Heart Ventricles; Hemodynamics; In Vitro Techniques; Male; Mice; Myocardial Contraction; Ouabain; Rabbits; Time Factors	1976
Effects of sinoaortic denervation on the reflex actions of digoxin and a polar aminocardenolide. Journal of cardiovascular pharmacology, 1992, Volume: 19, Issue:1 Topics: Animals; Blood Pressure; Cardiac Glycosides; Denervation; Digitoxigenin; Digoxin; Dobutamine; Dogs; Heart Rate; Nerve Endings; Neurons, Afferent; Ouabain; Pressoreceptors; Reflex; Sinoatrial Node; Sympathetic Nervous System; Vagus Nerve	1992
Effect of transient vagal cold blockade upon reflex actions of a polar and nonpolar cardiac glycoside. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 262, Issue:3 Topics: Animals; Atropine; Cold Temperature; Digitoxigenin; Digoxin; Dogs; Female; Hemodynamics; Infusions, Intravenous; Male; Nerve Block; Reflex; Sympathetic Nervous System; Vagus Nerve	1992
Different patterns of autonomic nerve activity produced by a polar vs. a neutral cardiac glycoside. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 253, Issue:1 Topics: Animals; Autonomic Nervous System; Blood Pressure; Cardiac Glycosides; Digitoxigenin; Digoxin; Dogs; Female; Heart; Heart Rate; Male; Pressoreceptors; Reflex; Sympathetic Nervous System; Vagus Nerve	1990
Comparative ability of digoxin and an aminosugar cardiac glycoside to bind to and inhibit Na+,K+-adenosine triphosphatase. Effect of potassium. Biochemical pharmacology, 1989, Nov-01, Volume: 38, Issue:21 Topics: Animals; Binding Sites; Binding, Competitive; Cardiac Glycosides; Digitoxigenin; Digoxin; Dogs; Dose-Response Relationship, Drug; Drug Synergism; Kinetics; Myocardium; Potassium; Sodium-Potassium-Exchanging ATPase	1989
Effect of an aminocardenolide and digoxin upon atrioventricular refractory period in the dog. The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:3 Topics: Animals; Atrioventricular Node; Atropine; Digitoxigenin; Digoxin; Dogs; Female; Heart Conduction System; Male; Metoprolol; Neural Conduction; Pressoreceptors; Refractory Period, Electrophysiological; Sympathectomy	1985
Localization of the neurally mediated coronary vasoconstrictor properties of digitalis in the cat. Circulation research, 1981, Volume: 49, Issue:1 Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Cats; Central Nervous System; Coronary Vessels; Digitalis Glycosides; Digitoxigenin; Female; Male; Medulla Oblongata; Ouabain; Vascular Resistance; Vasoconstrictor Agents	1981
Metabolism and cardiac actions of a polar aminocardenolide and digoxin in the conscious dog. The Journal of pharmacology and experimental therapeutics, 1983, Volume: 226, Issue:1 Topics: Animals; Blood Pressure; Digitoxigenin; Digoxin; Dogs; Feces; Female; Heart; Heart Rate; Kinetics; Male; Myocardial Contraction	1983
Adrenergic and cholinergic mechanisms in digitalis inotropy. The Journal of pharmacology and experimental therapeutics, 1982, Volume: 223, Issue:3 Topics: Animals; Blood Pressure; Digitalis Glycosides; Digitoxigenin; Digoxin; Dogs; Female; Heart; Heart Rate; Male; Myocardial Contraction; Parasympathetic Nervous System; Sympathetic Nervous System	1982
Renal tubular transport of a polar cardiac glycoside, ASI-222, in rats; clearance and micropuncture studies. The Journal of pharmacology and experimental therapeutics, 1981, Volume: 218, Issue:3 Topics: Animals; Biological Transport; Cardiac Glycosides; Digitoxigenin; Glomerular Filtration Rate; Half-Life; Kidney Tubules; Male; Metabolic Clearance Rate; Rats	1981
Effect of halothane on in vivo and in vitro cardiotoxicity of an aminocardenolide. Journal of cardiovascular pharmacology, 1994, Volume: 23, Issue:6 Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Consciousness; Digitalis Glycosides; Digitoxigenin; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Female; Halothane; Heart Diseases; Male; Purkinje Fibers	1994