Page last updated: 2024-09-04

as 3201 and ponalrestat

as 3201 has been researched along with ponalrestat in 2 studies

Compound Research Comparison

Studies (as 3201)	Trials (as 3201)	Recent Studies (post-2010) (as 3201)	Studies (ponalrestat)	Trials (ponalrestat)	Recent Studies (post-2010) (ponalrestat)
33	7	12	165	23	12

Protein Interaction Comparison

Protein	Taxonomy	ponalrestat (IC50)
Aldo-keto reductase family 1 member B1	Rattus norvegicus (Norway rat)	0.616
Aldo-keto reductase family 1 member B1	Homo sapiens (human)	0.048
Aldo-keto reductase family 1 member B1	Bos taurus (cattle)	0.022
Aldo-keto reductase family 1 member A1	Sus scrofa (pig)	2
Aldo-keto reductase family 1 member B1	Sus scrofa (pig)	0.021

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (50.00)	18.2507
2000's	1 (50.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Fujitani, B; Komiya, M; Kuromiya, A; Matsumoto, J; Murata, M; Negoro, T; Ono, Y; Suzuki, K; Ueda, S	1
Degliesposti, G; Ferrari, AM; Rastelli, G; Sgobba, M	1

Other Studies

2 other study(ies) available for as 3201 and ponalrestat

Article	Year
Novel, highly potent aldose reductase inhibitors: (R)-(-)-2-(4-bromo-2-fluorobenzyl)-1,2,3,4- tetrahydropyrrolo[1,2-a]pyrazine -4-spiro-3'-pyrrolidine-1,2',3,5'-tetrone (AS-3201) and its congeners. Journal of medicinal chemistry, 1998, Oct-08, Volume: 41, Issue:21 Topics: Aldehyde Reductase; Animals; Crystallography, X-Ray; Diabetes Mellitus, Experimental; Enzyme Inhibitors; In Vitro Techniques; Lens, Crystalline; Male; Molecular Conformation; Pyrazines; Rats; Rats, Wistar; Sciatic Nerve; Sorbitol; Spiro Compounds; Stereoisomerism; Structure-Activity Relationship; Swine	1998
Validation of an automated procedure for the prediction of relative free energies of binding on a set of aldose reductase inhibitors. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Aldehyde Reductase; Binding Sites; Binding, Competitive; Computer Simulation; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Inhibitory Concentration 50; Models, Biological; Molecular Structure; Thermodynamics	2007

Article

Year

Novel, highly potent aldose reductase inhibitors: (R)-(-)-2-(4-bromo-2-fluorobenzyl)-1,2,3,4- tetrahydropyrrolo[1,2-a]pyrazine -4-spiro-3'-pyrrolidine-1,2',3,5'-tetrone (AS-3201) and its congeners.

Journal of medicinal chemistry, 1998, Oct-08, Volume: 41, Issue:21

Topics: Aldehyde Reductase; Animals; Crystallography, X-Ray; Diabetes Mellitus, Experimental; Enzyme Inhibitors; In Vitro Techniques; Lens, Crystalline; Male; Molecular Conformation; Pyrazines; Rats; Rats, Wistar; Sciatic Nerve; Sorbitol; Spiro Compounds; Stereoisomerism; Structure-Activity Relationship; Swine

1998

Validation of an automated procedure for the prediction of relative free energies of binding on a set of aldose reductase inhibitors.

Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24

Topics: Aldehyde Reductase; Binding Sites; Binding, Competitive; Computer Simulation; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Inhibitory Concentration 50; Models, Biological; Molecular Structure; Thermodynamics

2007