artenimol has been researched along with artesunic acid in 192 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (4.17) | 18.7374 |
| 1990's | 21 (10.94) | 18.2507 |
| 2000's | 59 (30.73) | 29.6817 |
| 2010's | 81 (42.19) | 24.3611 |
| 2020's | 23 (11.98) | 2.80 |
| Authors | Studies |
|---|---|
| Huo, JZ; Xia, WJ; Xue, M; Zhou, ZT | 1 |
| Song, ZY; Zhao, KC | 1 |
| Gu, HM; Peters, W; Warhurst, DC | 1 |
| Li, ZL; Peters, W; Robinson, BL; Warhurst, DC | 1 |
| Chen, DX; Ma, JM; Sun, JH; Yang, SD | 1 |
| Anders, JC; Chung, H; Theoharides, AD; Zhou, ZM | 1 |
| Ma, JM; Song, ZY; Sun, JH; Yang, SD | 1 |
| Li, CH; Li, R; Li, X; Liao, ZY; Zhong, JJ; Zhou, LL | 1 |
| Carlqvist, J; Edlund, PO; Jin, YH; Westerlund, D; Wu, BL | 1 |
| Fu, LC; Guo, XB; Jian, HX; Li, GQ; Wang, XH | 1 |
| Janse, CJ; Kos, J; Lugt, CB; Waters, AP | 1 |
| Gao, HL; Long, ZZ; Xie, SS; Yang, SX | 1 |
| Anh, TK; Batty, KT; Binh, TQ; Davis, TM; Ilett, KF; Thu, LT | 1 |
| Batty, KT; Davis, ME; Davis, T; Ilett, KF | 1 |
| Davis, TM; Johnston, WA; Manning, LS; Skinner, TS | 1 |
| Benakis, A; Loutan, L; Paris, M; Plessas, CT; Plessas, ST | 1 |
| Heppner, DG; Kawamoto, F; Nguyen, TD; Sookto, P; Trieu, NT; Wimonwattrawatee, T; Wongsrichanalai, C | 1 |
| Mansor, SM; Mordi, MN; Navaratnam, V | 1 |
| Batty, KT; Binh, TQ; Davis, TM; Hung, NC; Ilett, KF; Kim, NV; Mai, TX; Powell, SM; Thien, HV; Thu, LT; Tien, NP | 1 |
| Congpoung, K; Karbwang, J; Na-Bangchang, K; Thanavibul, A; Ubalee, R | 1 |
| Benakis, A; Halpaap, B; Kremsner, PG; Ndjave, M; Paris, M | 1 |
| Dong, Y; Huang, KG; Liao, MZ; Liu, DQ; Yang, HL; Yang, PF; Yang, YM; Zhang, CY | 1 |
| Congpuong, K; Hung, LN; Karbwang, J; Molunto, P; Na-Bangchang, K | 1 |
| Xu, JH; Zhang, YP | 1 |
| de Vries, PJ; Ha, LD; Kager, PA; Khanh, NX; Koopmans, R; van Boxtel, CJ | 1 |
| Li, Y; Wu, YL | 1 |
| Looareesuwan, S; Wilairatana, P | 1 |
| Eggelte, TA; van Agtmael, MA; van Boxtel, CJ; Vuong, TD | 1 |
| Petavy, AF; Peyron, F; Saccharin, C; Sarciron, ME | 1 |
| Brewer, TG; Genovese, RF; Newman, DB | 1 |
| Batty, KT; Binh, TQ; Davis, TM; Hung, NC; Ilett, KF; Phuong, HL; Phuong, VD; Powell, SM; Thien, HV | 1 |
| Ashton, M; Davis, TM; Hai, TN; Huong, DX; Ilett, KF; Zhang, SQ | 1 |
| Tu, Y | 1 |
| Green, MD; Mount, DL; Wirtz, RA | 1 |
| Brewer, TG; Eamsila, C; Jongsakul, K; Keeratithakul, G; Kyle, DE; Li, Q; Luesutthiviboon, L; Sirisopana, N; Teja-Isavadharm, P; Watt, G | 1 |
| Chen, Y; Ni, X | 1 |
| Batty, KT; Binh, TQ; Davis, TM; Hung, NC; Ilett, KF; Phuong, HL; Powell, SM; Thu, le TA | 1 |
| Looareesuwan, S; Newton, PN; Nosten, F; Rasameesoroj, M; Ruangveerayuth, R; Siriyanonda, D; Slight, T; Suputtamongkol, Y; Teerapong, P; Teja-Isavadharm, P; van Vugt, M; White, NJ | 1 |
| Batty, KT; Davis, TM; Iletr, KE; Martin, J; Powell, SM | 1 |
| Batty, KT; Binh, TQ; Burchell, B; Davis, TM; Edwards, G; Ethell, BT; Hung, NC; Ilett, KF; Maggs, JL; Park, BK; Pirmohamed, M; Thu, le TA | 1 |
| Agus, C; Batty, KT; Binh, TQ; Chiswell, GM; Davis, TM; Ilett, KF; Phuöng, HL; Phuong, VD | 1 |
| Mankhetkorn, S; Reungpatthanaphong, P | 1 |
| Chalermrut, K; Krudsood, S; Looareesuwan, S; Pengruksa, C; Silachamroon, U; Srivilairit, S; Treeprasertsuk, S; Wilairatana, P | 1 |
| Chen, HH; Fang, X; Zhou, HJ | 1 |
| Batty, KT; Davis, TM; Ilett, KF; Kotecka, BM; Rieckmann, KH | 1 |
| Brewer, TG; Kyle, DE; Peggins, JO; Teja-Isavadharm, P; Webster, HK; White, NJ | 1 |
| Alpers, MP; Barrett, PH; Bockarie, M; Davis, TM; Dufall, K; Ilett, KF; Karunajeewa, HA; Kemiki, A; Vicini, P | 1 |
| Ashley, EA; Brockman, A; Hutagalung, R; Krudsood, S; Leowattana, W; Looareesuwan, S; McGready, R; Nosten, F; Phaiphun, L; Srivilairit, S; White, NJ; Wilairatana, P | 1 |
| Fleckenstein, L; Kirsch, LE; Murry, DJ; Naik, H | 1 |
| Chalermrut, K; Kano, S; Krudsood, S; Looareesuwan, S; Matangkasombut, O; Molunto, P; Na-Bangchang, K; Silachamroon, U; Tangpukdee, N; Tasanor, O | 1 |
| Chanthap, L; Na-Bangchang, K; Nivanna, N; Socheat, D; Sovannarith, T; Suksom, D; Tsuyuoka, R | 1 |
| Ashley, EA; Barends, M; Hutagalung, R; Looareesuwan, S; McGready, R; Nosten, F; Phaiphun, L; Proux, S; Slight, T; Thwai, KL; White, NJ | 1 |
| Chalermrut, K; Kano, S; Krudsood, S; Looareesuwan, S; Pengruksa, C; Phongtananant, S; Silachamroon, U; Srivilairit, S; Tangpukdee, N; Thanachartwet, W; Wilairatana, P | 1 |
| Cho, T; Gilveray, G; Looareesuwan, S; McGready, R; Nosten, F; Stepniewska, K; Ward, SA; White, NJ | 1 |
| Keiser, J; Shu-Hua, X; Tanner, M; Utzinger, J | 1 |
| Bojang, K; Bruneton, C; Christophel, EM; Day, NP; Fernandez, F; Green, MD; Greenwood, BM; Kaur, H; Malenga, G; McGready, R; Millet, P; Newton, PN; Nosten, F; Palmer, K; Phanouvong, S; Proux, S; Singhasivanon, P; Sunjio, M; Talisuna, AO; White, NJ; Whitty, CJ | 1 |
| Duffy, PE; Mutabingwa, TK | 1 |
| Ashley, E; Aye, KZ; Barends, M; Htet, L; Kyaw, MK; Lindegardh, N; Lwin, S; Phe, O; Singtoroj, T; Smithuis, F; Stepniewska, K; White, NJ | 1 |
| Barends, M; Keola, S; Khanthavong, M; Lindegårdh, N; Mayxay, M; Newton, PN; Phetsouvanh, R; Phompida, S; Pongvongsa, T; Stepniewska, K; Thongpraseuth, V; White, NJ | 1 |
| Barnes, KI; Chierakul, W; Evans, AC; Newton, PN; Ruangveerayuth, R; Smith, PJ; White, NJ | 1 |
| Agbenyega, T; Barnes, KI; Di Perri, G; Folb, P; Gomes, M; Krishna, S; Krudsood, S; Looareesuwan, S; Mansor, S; McIlleron, H; Miller, R; Molyneux, M; Mwenechanya, J; Navaratnam, V; Nosten, F; Olliaro, P; Pang, L; Ribeiro, I; Simpson, JA; Tembo, M; van Vugt, M; Ward, S; Weerasuriya, K; White, NJ; Win, K | 1 |
| Cambon, N; Davis, TM; Dunlop, AM; England, M; Heidecker, JL; Ilett, KF; Keller, TG; Page-Sharp, M | 1 |
| Atemnkeng, MA; De Cock, K; Plaizier-Vercammen, J | 1 |
| Anderson, T; Barends, M; Brockman, A; Jaidee, A; Mayxay, M; Nair, S; Newton, PN; Phetsouvanh, R; Phompida, S; Pongvongsa, T; Sudimack, D; White, NJ | 1 |
| Ashley, EA; Brockman, A; Chan, S; Goubert, L; Janssens, B; Nong, S; Socheat, D; Uong, S; Van Damme, W; van Herp, M | 1 |
| Gosi, P; Limsomwong, C; Veerasubramanian, P; Walsh, DS | 1 |
| Anstey, NM; Ebsworth, EP; Hasugian, AR; Kenangalem, E; Laihad, F; Maristela, R; Penttinen, PM; Price, RN; Purba, HL; Tjitra, E; Wuwung, RM | 1 |
| Davis, TM; Ilett, KF; Karunajeewa, HA; Manning, L; Mueller, I | 1 |
| Cartwright, A; Chan, HW; Gomes, MF; Haynes, RK; Lung, CM; Ng, NC; Shek, LY; Williams, ID; Wong, HN | 1 |
| Lai, CS; Mansor, SM; Nair, NK; Navaratnam, V; Olliaro, PL | 1 |
| Bernasconi, A; Casapia, M; D'Alessandro, U; Delgado, C; Erhart, A; Fanello, C; Gamboa, D; Grande, T; Llanos-Cuentas, A; Torres, K | 1 |
| Cordonnier, JA; Jansen, FH; Soomro, SA; Van Quekelberghe, SA | 1 |
| Gu, Y; Li, Q; Melendez, V; Weina, P | 1 |
| Aglioni, C; Bressolle, FM; Mosnier, J; Parzy, D; Sinou, V; Taudon, N | 1 |
| Danh, PT; Diem Thuy, LT; Na-Bangchang, K; Ngoc Hung, L | 1 |
| Li, Q; Si, Y; Smith, KS; Weina, PJ; Zeng, Q | 1 |
| Arima, A; Bernard, F; Clark, RL; Gristwood, W; Harrell, A; Makori, N; Nakata, Y; White, TE; Wier, PJ | 1 |
| Hou, J; Wang, D; Wang, H; Zhang, R | 1 |
| Day, NP; Dondorp, AM; Hanpithakpong, W; Kamanikom, B; Lindegardh, N; Singhasivanon, P; White, NJ | 1 |
| Danh, PT; Hung, le N; Na-Bangchang, K; Thuy, le TD | 1 |
| Davis, TM; Gomorrai, PS; Griffin, S; Ilett, KF; Karunajeewa, HA; Kotab, K; Lautu, D; Law, I; Lin, E; Mueller, I; Oa, O; Page-Sharp, M; Salman, S; Senn, M; Siba, P; Suano, P; Tarongka, N; Ura, A; Wong, R | 1 |
| Lai, CS; Mansor, SM; Muniandy, A; Nair, NK; Navaratnam, V; Olliaro, PL | 1 |
| Decosterd, L; Gruyer, MS; Keiser, J; Mercier, T; Perrottet, N; Zanolari, B | 1 |
| Bandyopadhyay, N; Duparc, S; Kirby, PL; Miller, AK; Ward, SA; Winstanley, PA; Wootton, DG | 1 |
| Donegan, S; Garner, P; Olliaro, P; Sinclair, D; Zani, B | 1 |
| An, SS; Ariey, F; Chotivanich, K; Das, D; Day, NP; Dondorp, AM; Hanpithakpong, W; Herdman, T; Imwong, M; Lee, SJ; Lim, P; Lindegardh, N; Lwin, KM; Nosten, F; Phyo, AP; Ringwald, P; Silamut, K; Singhasivanon, P; Socheat, D; Tarning, J; White, NJ; Yeung, S; Yi, P | 1 |
| Atipas, S; Chatsiricharoenkul, S; Kaewkungwal, J; Khuhapinant, A; Kongpatanakul, S | 1 |
| Liu, HF; Liu, Y; Qiu, ZP; Shen, XS; Su, Q; Xie, YX; Xu, JY | 1 |
| Giha, HA | 1 |
| Craft, JC; Fleckenstein, L; Jang, IJ; Kirsch, LE; Naik, H; Shin, CS; Tan, B; Yu, KS | 1 |
| Anstey, NM; Fobia, W; Hasanuddin, A; Kenangalem, E; Lampah, DA; Poespoprodjo, JR; Price, RN; Sugiarto, P; Tjitra, E | 1 |
| Bacchieri, A; Bhattacharya, PC; Corsi, M; Dev, V; Dubhashi, N; Duparc, S; Ghosh, SK; Keomany, S; Khanthavong, M; Krudsood, S; Kumar, A; Mayxay, M; Newton, PN; Phyo, AP; Pongvongsa, T; Pukittayakamee, S; Pukrittayakamee, S; Rao, BH; Ruangveerayuth, R; Ubben, D; Uthaisil, C; Valecha, N | 1 |
| Clark, RL; Gristwood, WE; Harrell, AW; Lewsley, R; Wilson, R | 1 |
| Fortin, A; Jansen, FH; Verbeeck, RK | 1 |
| Keola, S; Keomany, S; Khanthavong, M; Khomthilath, T; Mayxay, M; Newton, PN; Phompida, S; Pongvongsa, T; Souvannasing, P; Stepniewska, K; Ubben, D; Valecha, N; White, NJ | 1 |
| Apinan, R; Chanarat, N; Fukuda, MM; Lim, A; Meléndez, V; Miller, RS; Saunders, D; Siripokasupkul, R; Siriyanonda, D; Teja-Isavadharm, P; Wannaying, S; Weina, PJ | 1 |
| Bai, KH; Liu, T; Wang, RL; Xing, J; Zhang, LF; Zhang, SQ | 1 |
| Duthaler, U; Huwyler, J; Keiser, J | 1 |
| Atibu, J; Bose, C; Capparelli, EV; Douoguih, M; Fleckenstein, L; Hemingway-Foday, J; Koch, MA; Lokomba, V; Meshnick, SR; Onyamboko, MA; Ryder, RW; Tshefu, AK; Wesche, D; Wright, LL | 1 |
| Atibu, J; Bose, C; Capparelli, E; Douoguih, M; Fleckenstein, L; Hemingway-Foday, J; Koch, MA; Lokomba, V; Meshnick, S; Morris, CA; Onyamboko, MA; Ryder, RW; Tshefu, AK; Wesche, D; Wright, L | 1 |
| Dai, JR; Li, HJ; Li, YZ; Liang, YS; Qu, GL; Tao, YH; Wang, W; Wei, JY; Xing, YT | 1 |
| Borghini-Fuhrer, I; Duparc, S; Fleckenstein, L; Jung, D; Morris, CA; Shin, CS | 1 |
| Hanpithakpon, W; Hlaing, N; Lindegardh, N; McGready, R; Nosten, F; Phyo, AP; Rijken, MJ; Singhasivanon, P; Tarning, J; Than, HH; White, NJ; Zin, NT | 1 |
| Chen, SM; Ding, J; Lu, JJ; Meng, LH | 1 |
| Bouyou Akotet, MK; Chimalizeni, Y; Duparc, S; Duscha, M; Humberg, A; Issifou, S; Kawaza, K; Köhler, C; Kombila, M; Kösters, K; Kremsner, PG; Krishna, S; Kun, JF; Miller, RS; Möhrle, J; Mordmüller, B; Planche, T; Simpson, JA; Taylor, T; Teja-Isavadharm, P; Weina, P | 1 |
| Borghini-Fuhrer, I; Duparc, S; Fleckenstein, L; Jung, D; Lopez-Lazaro, L; Methaneethorn, J; Morris, CA; Pokorny, R; Shin, CS | 1 |
| Byakika-Kibwika, P; de Vries, PJ; Hanpithakpong, W; Katabira, E; Lamorde, M; Lindegardh, N; Mayanja-Kizza, H; Mayito, J; Merry, C; Nabukeera, L; Obua, C; Pakker, N; Tarning, J | 1 |
| Cui, L; Fan, Q; Li, J; Meng, H; Miao, M; Parker, D; Wang, H; Wang, Z; Wu, L; Yang, Z; Zhang, R; Zhao, Z | 1 |
| D'Alessandro, U; Donegan, S; Tudur Smith, C; Williamson, P | 1 |
| McEwen, J | 1 |
| Bacchieri, A; Bhattacharyya, PC; Corsi, M; Dev, V; Dubashi, N; Gargano, N; Ghosh, SK; Kumar, A; Rao, BH; Srivastava, B; Tommasini, S; Ubben, D; Valecha, N | 1 |
| Anstey, NM; Chalfein, F; Haynes, RK; Kenangalem, E; Marfurt, J; Möhrle, JJ; Piera, KA; Prayoga, P; Price, RN; Sebayang, B; Wabiser, F; Wirjanata, G; Wittlin, S | 1 |
| Bethell, D; Chanthap, L; Fukuda, M; Khemawoot, P; Lin, J; Noedl, H; Ringwald, P; Rutvisuttinunt, W; Saunders, D; Se, Y; Siripokasupkul, R; Smith, B; Socheat, D; Sriwichai, S; Teja-Isavadharm, P; Timmermans, A; Tyner, S; Vanachayangkul, P | 1 |
| Charman, SA; Gamo-Benito, J; Humberstone, A; Jamsen, KM; McCaw, J; Moehrle, J; Price, RN; Simpson, JA; Smith, K; Zaloumis, S | 1 |
| Bethell, D; Chaichana, P; Chaorattanakawee, S; Fukuda, M; Lon, C; Noedl, H; Rutvisuttinunt, W; Saunders, DL; Schaecher, K; Se, Y; Socheat, D; Teja-Isavadharm, P; Tyner, SD; Walsh, DS; Yingyuen, K | 1 |
| Boni, MF; Dolecek, C; Dong, le T; Farrar, J; Hien, TT; Long, le T; Merson, L; Nha-Ca, NT; Phu, NH; Ringwald, P; Stepniewska, K; Thai, CQ; Thai, le H; Thanh, NV; Thuan, PD; Thuy-Nhien, NT; Toi, PV; White, NJ; Wolbers, M | 1 |
| Ariey, F; Beck, HP; Csajka, C; Decosterd, LA; Duong, S; Genton, B; Guidi, M; Kabanywanyi, AM; Olliaro, P; Staehli Hodel, EM | 1 |
| Baird, JK; Basri, H; Ekawati, LL; Elyazar, I; Farrar, J; Meilia, RA; Nurleila, S; Putri, FA; Setiabudy, R; Sudoyo, H; Sutanto, I; Taylor, WR; Tjahjono, B | 1 |
| Day, NP; Dondorp, AM; Gesase, S; Hendriksen, IC; Kent, A; Lemnge, MM; Lindegardh, N; Mtove, G; Reyburn, H; Tarning, J; von Seidlein, L; White, NJ | 1 |
| Efferth, T; Erich, SA; Fleckenstein, L; Grinwis, GC; London, CA; Mol, JA; Rutteman, GR; Spee, B | 1 |
| Efferth, T; Eichhorn, T; Schneider, D; Veerappan, A; Zeino, M | 1 |
| He, G; Qi, H; Qiao, C; Wang, M; Wang, W; Wen, F; Yang, J; Zhang, H | 1 |
| Aston, JA; Chappell, MJ; Hall, AJ; Ward, SA | 1 |
| Borghini-Fuhrer, I; Duparc, S; Fleckenstein, L; Jung, D; Morris, CA; Shin, CS; Tan, B | 1 |
| Ando, E; Chikazawa, S; Higuchi, S; Hori, Y; Hoshi, F; Ito, N; Kanai, K; Kitahara, Y | 1 |
| Cui, L; Cui, Y; Wang, B; Wang, M; Yan, G; Zhou, G | 1 |
| Bellettre, X; Bouchaud, O; Michel, JF; Pull, L; Siriez, JY | 1 |
| Cremers, S; Fidock, DA; Henrich, PP; Kyle, DE; O'Brien, C; Sáenz, FE | 1 |
| Burkholder, B; Bustos, MD; Delacollette, C; Wongsrichanalai, C | 1 |
| Ashton, M; Ericsson, T; Hoffmann, KJ; Sundell, J; Torkelsson, A | 1 |
| Donegan, S; Gathu, M; Olliaro, PL; Sinclair, D; Zani, B | 1 |
| Li, GX; Wang, W; Wang, YH; Xu, FL; Zhang, XG; Zhao, SS | 1 |
| Awad, AI; Elamin, SB; Matar, KM | 1 |
| Cui, L; Cui, Y; Guo, S; He, L; Nan, T; Tan, G; Wang, B; Zhang, R; Zhang, W | 1 |
| Ahmed, A; Geditz, MC; Heinkele, G; Hofmann, U; Kerb, R; Kremsner, PG; Schwab, M | 1 |
| Hickman, MR; Li, Q; Melendez, V; Miller, SR; Ogutu, B; Otieno, W; Polhemus, M; Remich, S; Smith, B; Teja-Isavadharm, P; Weina, PJ | 1 |
| Bathurst, I; Chaorattanakawee, S; Ding, XC; Lanteri, CA; Lon, C; Rutvisuttinunt, W; Saunders, DL; Tyner, SD; Yingyuen, K | 1 |
| Batty, KT; Senarathna, SM | 1 |
| Basilico, N; Bosisio, E; Colombo, E; Dell'Agli, M; Haynes, RK; Magenta, D; Parapini, S; Sangiovanni, E; Taramelli, D | 1 |
| Äbelö, A; Ashton, M; Blank, A; Ericsson, T; von Hagens, C | 1 |
| Gebru, T; Held, J; Mordmüller, B | 1 |
| Ashton, M; Birgersson, S; Blank, A; Ericsson, T; Hagens, Cv; Hoffmann, KJ | 1 |
| Ashley, EA; Blessborn, D; Chairat, K; Day, NP; Hanboonkunupakarn, B; Jittamala, P; Lee, SJ; Nosten, F; Panapipat, S; Pukrittayakamee, S; Tarning, J; Thana, P; White, NJ | 1 |
| Claeys, Y; D'Alessandro, U; De Crop, M; Halidou, T; Kalanda, G; Menten, J; Mulenga, M; Mutabingwa, T; Mwakazanga, D; Mwapasa, V; Nambozi, M; Phiri, LK; Ravinetto, R; Schurmans, C; Tagbor, H; Thriemer, K; Traore, M; Valea, I; Van Geertruyden, JP | 1 |
| Wang, FY; Wang, YB; Wei, DD; Wei, YB; Yin, B; Yu, ZH; Zhang, BG; Zhao, GH | 1 |
| Day, NP; Hanpithakpon, W; Hlaing, N; Kloprogge, F; McGready, R; Nosten, F; Phyo, AP; Rijken, MJ; Tarning, J; Than, HH; White, NJ; Zin, NT | 1 |
| Gao, CZ; Gong, XS; Jiang, RJ; Liao, XL; Ma, X; Xie, HD; Yang, B; Zhao, YL | 1 |
| Hastings, IM; Hodel, EM; Kay, K | 1 |
| Bertinaria, M; Carvalho, LJ; Frangos, JA; Fruttero, R; Gasco, A; Guglielmo, S; Hofer, A; Marini, E; Martins, YC; Orjuela-Sanchez, P; Zanini, GM | 1 |
| Bonfill, M; Cusido, RM; Dilshad, E; Mirza, B; Ramirez Estrada, K | 1 |
| Beeching, NJ; Bell, DJ; Chiodini, PL; Lalloo, DG; Shingadia, D; Whitty, CJM | 1 |
| Jangid, AG; Mistri, HN; Patel, KR; Rathod, DM; Sanyal, M; Shrivastav, PS | 1 |
| Hu, M; Li, F; Liu, W; Liu, Y; Liu, Z; Lu, L; Ou, R; Tong, Y; Wu, J; Zhang, G; Zheng, H; Zheng, L | 1 |
| Baker, SD; Buaboonnam, J; Drenberg, CD; Fan, Y; Guy, RK; Hu, S; Li, L; Orwick, SJ; Rubnitz, J; Shelat, AA | 1 |
| Amalvict, R; Benoit, N; Diatta, B; Diawara, S; Diémé, Y; Fall, B; Fall, M; Gendrot, M; Madamet, M; Nakoulima, A; Pradines, B; Wade, B; Wade, KA | 1 |
| Cabral, L; Cristiano, ML; Lobo, L; Nogueira, F; Sousa, Bd | 1 |
| Amalvict, R; Benoit, N; Briolant, S; Diatta, B; Diawara, S; Diémé, Y; Fall, B; Fall, M; Gendrot, M; Kounta, MB; Madamet, M; Nakoulima, A; Pradines, B; Wade, B; Wade, KA | 1 |
| Buyze, J; D'Alessandro, U; Hachizovu, S; Kabuya, JB; Kasongo, W; Mulenga, J; Mulenga, M; Mwakazanga, D; Nambozi, M; Van Geertruyden, JP | 1 |
| Alifrangis, M; Cairns, M; Magnussen, P; Osarfo, J; Tagbor, H | 1 |
| Abd El-Aty, AM; Choi, JM; Hacımüftüoğlu, A; Kang, YS; Kim, SK; Shim, JH; Shin, HC; Zheng, W | 1 |
| Blessborn, D; Chairat, K; Day, NPJ; Hanboonkunupakarn, B; Hanpithakpong, W; Jittamala, P; Pukrittayakamee, S; Tarning, J; White, NJ | 1 |
| Cao, P; Cromer, D; Davenport, MP; Dini, S; Fowkes, FJI; Khoury, DS; McCaw, JM; Simpson, JA; Zaloumis, SG | 1 |
| Bartalesi, F; Bartolesi, AM; Bartoloni, A; Berni, A; Boccolini, D; Buonamici, C; Ciccone, N; Corti, G; Di Lauria, N; Garofalo, G; Gradoni, L; Mencarini, J; Niccolini, F; Poggesi, L; Romi, R; Rossolini, GM; Severini, C; Suardi, LR; Zammarchi, L | 1 |
| Garrido Jareño, M; Otero Reigada, MDC; Peman García, J; Ramírez Cuentas, JH; Roselló Guijarro, M; Urtasun Erburu, A | 1 |
| Guan, J; Huang, P; Li, F; Liu, L; Liu, Z; Lu, L; Qi, X; Su, T; Wang, D; Wang, Y | 1 |
| Bienvenu, AL; Bonnot, G; Kouakou, YI; Lavoignat, A; Leboucher, G; Picot, S; Tod, M | 1 |
| Guo, X; He, H; Huang, S; Liu, Q; Luo, J; Zhang, Y | 1 |
| Adisa, BA; Oludele, OJ; Olufunso, OO | 1 |
| Blessborn, D; Byakika-Kibwika, P; Lamorde, M; Ssenyonga, R; Tarning, J | 1 |
| Ahmad, RA; Kenangalem, E; Laksono, IS; Lampah, DA; Murhandarwati, EEH; Poespoprodjo, JR; Sikora, SA; Sugiarto, P | 1 |
| Kim, S; Lek, D; Mairet-Khedim, M; Popovici, J; Roesch, C; Witkowski, B | 1 |
| Duong, NTT; Duong, TT; Erhart, A; Guetens, P; Hien, NTT; Hieu, NL; Huan, RM; Kattenberg, JH; Mai, TT; Ngoc, NTH; Phuc, BQ; Rosanas-Urgell, A; Rovira-Vallbona, E; Van Hong, N; Xa, NX | 1 |
| Anvikar, AR; Ashley, EA; Chandramohan, D; Cohee, LM; D'Alessandro, U; Genton, B; Gilder, ME; Guérin, PJ; Juma, E; Kalilani-Phiri, L; Kennon, K; Kuepfer, I; Laufer, MK; Lwin, KM; Mansoor, R; McGready, R; Meshnick, SR; Mosha, D; Mwapasa, V; Mwebaza, N; Nambozi, M; Ndiaye, JA; Nosten, F; Nyunt, M; Ogutu, B; Parikh, S; Paw, MK; Phyo, AP; Pimanpanarak, M; Piola, P; Rijken, MJ; Saito, M; Sriprawat, K; Stepniewska, K; Tagbor, HK; Tarning, J; Tinto, H; Valéa, I; Valecha, N; White, NJ; Wiladphaingern, J | 1 |
| Gille, L; Machín, L; Monzote, L; Nápoles, R | 1 |
| Arey, R; Reisfeld, B | 1 |
| Ball, L; Bensman, TJ; Chilukuri, DM; Colangelo, PM; Earp, JC; Kitabi, E; O'Shaughnessy, E; Reynolds, KS; Smith, H; Yasinskaya, Y | 1 |
| Guo, X; He, H; Huang, S; Li, J; Liu, Q; Luo, J; Luo, Y; Wang, Y; Zhang, Y | 1 |
| Hughes, E; Jagannathan, P; Mohamed Ali, A; Savic, RM; Wallender, E | 1 |
| Cui, L; Han, H; Li, N; Li, P; Song, Q; Tong, Y; Yang, B; Zhang, G | 1 |
| Bancone, G; Carrara, VI; Chu, C; Duanguppama, J; Gilder, ME; Haohankhunnatham, W; Imwong, M; Konghahong, K; Lee, SJ; McGready, R; Min, AM; Nosten, F; Paw, MK; Phyo, AP; Pimanpanarak, M; Proux, S; Saito, M; Singhasivanon, P; Tun, NW; Turner, C; Viladpai-Nguen, J; White, NJ | 1 |
| Chai, L; Guo, W; Li, N; Li, Y; Ren, G; Wang, R; Wang, X; Yang, L; Yang, Q; Yi, B; Zhang, G; Zhang, S | 1 |
| Huang, C; Li, Y; Lu, H; Tang, J; Tang, Y; Wang, Y; Xiao, X; Yang, J; Zhang, Y; Zhong, Z | 1 |
| Baraka, V; Kamugisha, E; Kapesa, A; Kidenya, B; Konje, E; Marwa, K; Mukonzo, J; Swedberg, G | 1 |
| Grundmann, O; Hernandez Maldonado, J | 1 |
| Bruschi, F; Fabiani, S; L'Episcopia, M; Mangano, V; Motta, V; Severini, C; Sparavelli, R; Verdenelli, S | 1 |
| Avery, VM; Duffy, S | 1 |
| Chen, Y; Cheng, Y; Li, P; Liu, H; Lu, X; Ma, Y; Song, C; Wang, Y; Zhang, Z | 1 |
| Barman, M; Bhandari, V; Dandasena, D; Kamble, S; Sharma, P; Singh, S; Subudhi, M; Suresh, A | 1 |
| Baraka, V; Francis, F; Geertruyden, JV; Gesase, S; Kyaruzi, E; Lusingu, JPA; Madebe, R; Makenga, G; Minja, DTR; Mtove, G; Nakato, S | 1 |
| Arama, C; Beavogui, AH; Dicko, A; Djimde, A; Djimde, M; Fofana, B; Kayentao, K; Mens, PF; Ouedraogo, JB; Sagara, I; Schallig, HD; Sirima, SB; Tshiongo, JK | 1 |
| Guo, Z; Hua, H; Jiang, Y; Liu, Y; Wang, J; Zhang, H; Zhang, J | 1 |
15 review(s) available for artenimol and artesunic acid
| Article | Year |
|---|---|
Studies of qinghaosu and its active derivatives in biological materials and their pharmacokinetics.
Topics: Antimalarials; Artemether; Artemisinins; Artesunate; Sesquiterpenes; Structure-Activity Relationship | 1989 |
How Chinese scientists discovered qinghaosu (artemisinin) and developed its derivatives? What are the future perspectives?
Topics: Antimalarials; Artemether; Artemisinins; Artesunate; Drug Evaluation; Drug Resistance; Forecasting; Humans; Malaria, Falciparum; Medicine, Chinese Traditional; Sesquiterpenes | 1998 |
The rational use of qinghaosu and its derivatives: what is the future of new compounds?
Topics: Administration, Oral; Administration, Rectal; Adolescent; Adult; Antimalarials; Artemisinins; Artesunate; Drug and Narcotic Control; Drug Resistance; Female; Humans; Malaria, Falciparum; Male; Middle Aged; Registries; Sesquiterpenes; Suppositories; Thailand | 1998 |
Rectal administration of artemisinin derivatives for the treatment of malaria.
Topics: Administration, Rectal; Area Under Curve; Artemether; Artemisinins; Artesunate; Humans; Malaria; Sesquiterpenes | 2007 |
Artemisinin-based combination therapy for treating uncomplicated malaria.
Topics: Antimalarials; Artemisinins; Artesunate; Drug Combinations; Drug Therapy, Combination; Ethanolamines; Fluorenes; Humans; Lumefantrine; Malaria; Malaria, Falciparum; Malaria, Vivax; Mefloquine; Parasitemia; Pyrimethamine; Quinolines; Randomized Controlled Trials as Topic; Sulfadoxine | 2009 |
Artemisinin derivatives for treatment of uncomplicated Plasmodium falciparum malaria in Sudan: too early for too much hope.
Topics: Antimalarials; Artemisinins; Artesunate; Chloroquine; Drug Combinations; Drug Therapy, Combination; Humans; Malaria, Falciparum; Pyrimethamine; Sudan; Sulfadoxine; Treatment Failure | 2010 |
Review of the clinical pharmacokinetics of artesunate and its active metabolite dihydroartemisinin following intravenous, intramuscular, oral or rectal administration.
Topics: Administration, Oral; Administration, Rectal; Antimalarials; Artemisinins; Artesunate; Biological Availability; Half-Life; Humans; Injections, Intramuscular; Injections, Intravenous; Metabolic Clearance Rate; Time Factors | 2011 |
Monitoring antimalarial drug efficacy in the Greater Mekong Subregion: an overview of in vivo results from 2008 to 2010.
Topics: Antimalarials; Artemether; Artemisinins; Artesunate; Asia, Southeastern; Chloroquine; Directly Observed Therapy; Drug Resistance; Drug Therapy, Combination; Ethanolamines; Fluorenes; Humans; Lumefantrine; Malaria, Falciparum; Malaria, Vivax; Mefloquine; Parasitemia; Quinolines | 2013 |
Dihydroartemisinin-piperaquine for treating uncomplicated Plasmodium falciparum malaria.
Topics: Adult; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; Child; Drug Combinations; Drug Therapy, Combination; Ethanolamines; Fluorenes; Humans; Malaria, Falciparum; Mefloquine; Parasitemia; Quinolines; Randomized Controlled Trials as Topic | 2014 |
A review of dihydroartemisinin as another gift from traditional Chinese medicine not only for malaria control but also for schistosomiasis control.
Topics: Animals; Antimalarials; Artemether; Artemisinins; Artesunate; Drugs, Chinese Herbal; Female; Malaria, Falciparum; Mice; Praziquantel; Schistosomiasis japonica; Schistosomicides | 2014 |
Systematic review of artesunate pharmacokinetics: Implication for treatment of resistant malaria.
Topics: Administration, Intravenous; Administration, Oral; Antimalarials; Artemisinins; Artesunate; Asia, Southeastern; Drug Monitoring; Drug Resistance; Humans; Malaria; Malaria, Falciparum | 2019 |
Efficacy and tolerability of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: a systematic review and individual patient data meta-analysis.
Topics: Amodiaquine; Anti-Bacterial Agents; Antimalarials; Artemisinins; Artesunate; Atovaquone; Clindamycin; Drug Combinations; Drug Therapy, Combination; Female; Humans; Malaria, Falciparum; Mefloquine; Pregnancy; Pregnancy Complications, Parasitic; Proguanil; Pyrimethamine; Quinine; Quinolines; Sulfadoxine | 2020 |
Malaria PK/PD and the Role Pharmacometrics Can Play in the Global Health Arena: Malaria Treatment Regimens for Vulnerable Populations.
Topics: Amodiaquine; Anti-HIV Agents; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; Child, Preschool; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Drug Therapy, Combination; Female; Global Health; HIV Infections; Humans; Malaria; Malnutrition; Mefloquine; Models, Biological; Pregnancy; Pregnancy Complications, Parasitic; Pyrimethamine; Quinolines; Sulfadoxine; Vulnerable Populations | 2021 |
Therapeutic efficacy of artemether-lumefantrine, artesunate-amodiaquine and dihydroartemisinin-piperaquine in the treatment of uncomplicated Plasmodium falciparum malaria in Sub-Saharan Africa: A systematic review and meta-analysis.
Topics: Africa South of the Sahara; Amodiaquine; Antimalarials; Artemether; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; Drug Combinations; Ethanolamines; Humans; Malaria; Malaria, Falciparum; Piperazines; Plasmodium falciparum; Quinolines | 2022 |
Drug-Drug Interactions of Artemisinin-Based Combination Therapies in Malaria Treatment: A Narrative Review of the Literature.
Topics: Antimalarials; Artemether; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; Drug Combinations; Drug Interactions; Drug Therapy, Combination; Humans; Malaria; Malaria, Falciparum | 2022 |
53 trial(s) available for artenimol and artesunic acid
| Article | Year |
|---|---|
Pharmacokinetics of artemisinin and artesunate after oral administration in healthy volunteers.
Topics: Administration, Oral; Adult; Antimalarials; Area Under Curve; Artemisinins; Artesunate; Female; Half-Life; Humans; Male; Metabolic Clearance Rate; Middle Aged; Sesquiterpenes; Tablets | 1997 |
A pharmacokinetic and pharmacodynamic study of intravenous vs oral artesunate in uncomplicated falciparum malaria.
Topics: Administration, Oral; Adult; Antimalarials; Artemisinins; Artesunate; Female; Humans; Injections, Intravenous; Malaria, Falciparum; Male; Reference Values; Sesquiterpenes; Time Factors; Vietnam | 1998 |
Declining concentrations of dihydroartemisinin in plasma during 5-day oral treatment with artesunate for Falciparum malaria.
Topics: Adult; Antimalarials; Artemisinins; Artesunate; Chromatography, High Pressure Liquid; Electrochemistry; Humans; Malaria, Falciparum; Male; Sesquiterpenes | 1999 |
Pharmacokinetics and pharmacodynamics of intravenous artesunate in severe falciparum malaria.
Topics: Adult; Antimalarials; Area Under Curve; Artemisinins; Artesunate; Female; Half-Life; Humans; Infusions, Intravenous; Malaria, Falciparum; Male; Sesquiterpenes | 2001 |
Multiple dose study of interactions between artesunate and artemisinin in healthy volunteers.
Topics: Administration, Oral; Adult; Antimalarials; Area Under Curve; Artemisinins; Artesunate; Chromatography, High Pressure Liquid; Drug Administration Schedule; Drug Interactions; Half-Life; Humans; Linear Models; Male; Metabolic Clearance Rate; Sesquiterpenes | 2001 |
The pharmacokinetic properties of intramuscular artesunate and rectal dihydroartemisinin in uncomplicated falciparum malaria.
Topics: Administration, Rectal; Adult; Antimalarials; Area Under Curve; Artemisinins; Artesunate; Confidence Intervals; Cross-Over Studies; Female; Humans; Injections, Intramuscular; Injections, Intravenous; Malaria, Falciparum; Male; Sesquiterpenes; Statistics, Nonparametric | 2002 |
Comparison of oral artesunate and dihydroartemisinin antimalarial bioavailabilities in acute falciparum malaria.
Topics: Acute Disease; Adolescent; Adult; Aged; Antimalarials; Area Under Curve; Artemisinins; Artesunate; Biological Availability; Chromatography, High Pressure Liquid; Cross-Over Studies; Double-Blind Method; Female; Half-Life; Humans; Malaria, Falciparum; Male; Middle Aged; Sesquiterpenes; Spectrophotometry, Ultraviolet; Vietnam | 2002 |
Relative bioavailability of artesunate and dihydroartemisinin: investigations in the isolated perfused rat liver and in healthy Caucasian volunteers.
Topics: Administration, Oral; Adult; Animals; Antimalarials; Area Under Curve; Artemisinins; Artesunate; Biological Availability; Dose-Response Relationship, Drug; Female; Humans; Liver; Male; Rats; Rats, Wistar; Reference Values; Sesquiterpenes | 2002 |
Penetration of dihydroartemisinin into cerebrospinal fluid after administration of intravenous artesunate in severe falciparum malaria.
Topics: Adolescent; Adult; Artemisinins; Artesunate; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Injections, Intravenous; Malaria, Cerebral; Malaria, Falciparum; Male; Middle Aged; Sesquiterpenes | 2003 |
An open randomized clinical trial of Artecom vs artesunate-mefloquine in the treatment of acute uncomplicated falciparum malaria in Thailand.
Topics: Adolescent; Adult; Aged; Antimalarials; Artemisinins; Artesunate; Child; Drug Combinations; Drug Resistance, Multiple; Female; Humans; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Quinolines; Sesquiterpenes; Thailand; Trimethoprim | 2002 |
Disposition of artesunate and dihydroartemisinin after administration of artesunate suppositories in children from Papua New Guinea with uncomplicated malaria.
Topics: Aging; alpha-Thalassemia; Antimalarials; Artemisinins; Artesunate; Body Weight; Child; Chromatography, High Pressure Liquid; Female; Genotype; Half-Life; Humans; Malaria; Male; Models, Statistical; Papua New Guinea; Population; Sesquiterpenes; Sex Characteristics; Spectrometry, Mass, Electrospray Ionization; Suppositories; Tissue Distribution | 2004 |
Randomized, controlled dose-optimization studies of dihydroartemisinin-piperaquine for the treatment of uncomplicated multidrug-resistant falciparum malaria in Thailand.
Topics: Adolescent; Adult; Animals; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Drug Combinations; Drug Resistance, Multiple; Drug Therapy, Combination; Female; Humans; Infant; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Plasmodium falciparum; Quinolines; Sesquiterpenes; Thailand | 2004 |
The pharmacokinetics of oral dihydroartemisinin and artesunate in healthy Thai volunteers.
Topics: Administration, Oral; Adult; Antimalarials; Area Under Curve; Artemisinins; Artesunate; Biological Availability; Cross-Over Studies; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Sesquiterpenes; Thailand | 2004 |
Investigation of bioavailability, pharmacokinetics and safety of new pediatric formulations of artesunate and mefloquine.
Topics: Administration, Oral; Adolescent; Adult; Antimalarials; Artemisinins; Artesunate; Biological Availability; Drug Therapy, Combination; Humans; Malaria; Male; Mefloquine; Pediatrics; Sesquiterpenes | 2005 |
A randomized, controlled study of a simple, once-daily regimen of dihydroartemisinin-piperaquine for the treatment of uncomplicated, multidrug-resistant falciparum malaria.
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Drug Combinations; Drug Resistance, Multiple; Female; Humans; Infant; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Plasmodium falciparum; Quinolines; Sesquiterpenes | 2005 |
An open randomized clinical trial of Artekin vs artesunate-mefloquine in the treatment of acute uncomplicated falciparum malaria.
Topics: Acute Disease; Adolescent; Adult; Antimalarials; Artemisinins; Artesunate; Drug Combinations; Female; Humans; Malaria, Falciparum; Male; Mefloquine; Quinolines; Sesquiterpenes; Thailand; Treatment Outcome | 2005 |
Efficacy and effectiveness of dihydroartemisinin-piperaquine versus artesunate-mefloquine in falciparum malaria: an open-label randomised comparison.
Topics: Adolescent; Animals; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; Infant; Malaria, Falciparum; Male; Mefloquine; Myanmar; Plasmodium falciparum; Quinolines; Recurrence; Sesquiterpenes; Treatment Outcome | 2006 |
An open, randomized comparison of artesunate plus mefloquine vs. dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in the Lao People's Democratic Republic (Laos).
Topics: Administration, Oral; Adolescent; Adult; Antimalarials; Artemisinins; Artesunate; Child; Drug Therapy, Combination; Female; Humans; Laos; Malaria, Falciparum; Male; Mefloquine; Parasitemia; Quinolines; Recurrence; Sesquiterpenes; Treatment Failure; Treatment Outcome | 2006 |
The pharmacokinetics of intravenous artesunate in adults with severe falciparum malaria.
Topics: Administration, Oral; Adolescent; Adult; Age Factors; Antimalarials; Area Under Curve; Artemisinins; Artesunate; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electrochemistry; Female; Half-Life; Humans; Injections, Intravenous; Malaria, Falciparum; Male; Metabolic Clearance Rate; Middle Aged; Pilot Projects; Quinine; Sesquiterpenes; Severity of Illness Index; Thailand | 2006 |
A randomized open study to assess the efficacy and tolerability of dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in Cambodia.
Topics: Adolescent; Adult; Aged; Anemia; Antimalarials; Artemisinins; Artesunate; Cambodia; Child; Child, Preschool; Drug Therapy, Combination; Female; Genome, Protozoan; Humans; Infant; Malaria, Falciparum; Malaria, Vivax; Male; Mefloquine; Middle Aged; Quinolines; Recurrence; Sesquiterpenes; Treatment Outcome | 2007 |
Dihydroartemisinin-piperaquine versus artesunate-amodiaquine: superior efficacy and posttreatment prophylaxis against multidrug-resistant Plasmodium falciparum and Plasmodium vivax malaria.
Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Artesunate; Drug Resistance, Multiple; Drug Tolerance; Humans; Indonesia; Malaria, Falciparum; Malaria, Vivax; Plasmodium falciparum; Quinolines; Sesquiterpenes; Treatment Outcome | 2007 |
An analytical method with a single extraction procedure and two separate high performance liquid chromatographic systems for the determination of artesunate, dihydroartemisinin and mefloquine in human plasma for application in clinical pharmacological stu
Topics: Administration, Oral; Adult; Antimalarials; Artemisinins; Artesunate; Chemistry Techniques, Analytical; Chromatography, High Pressure Liquid; Drug Combinations; Drug Stability; Female; Freezing; Humans; Male; Mefloquine; Reproducibility of Results; Sesquiterpenes; Time Factors | 2007 |
A randomised controlled trial to assess the efficacy of dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in Peru.
Topics: Adolescent; Adult; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Female; Humans; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Peru; Quinolines; Sesquiterpenes | 2007 |
A trial of combination antimalarial therapies in children from Papua New Guinea.
Topics: Antimalarials; Artemether; Artemisinins; Artesunate; Child, Preschool; Chloroquine; Drug Therapy, Combination; Ethanolamines; Female; Fluorenes; Humans; Infant; Kaplan-Meier Estimate; Lumefantrine; Malaria, Falciparum; Malaria, Vivax; Male; Proportional Hazards Models; Pyrimethamine; Quinolines; Recurrence; Sulfadoxine | 2008 |
Validation of high performance liquid chromatography-electrochemical detection methods with simultaneous extraction procedure for the determination of artesunate, dihydroartemisinin, amodiaquine and desethylamodiaquine in human plasma for application in c
Topics: Administration, Oral; Amodiaquine; Antimalarials; Artemisinins; Artesunate; Chromatography, High Pressure Liquid; Drug Combinations; Drug Stability; Electrochemistry; Humans; Solid Phase Extraction | 2009 |
Pharmacokinetics of chlorproguanil, dapsone, artesunate and their major metabolites in patients during treatment of acute uncomplicated Plasmodium falciparum malaria.
Topics: Adult; Antimalarials; Area Under Curve; Artemisinins; Artesunate; Dapsone; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Drug Therapy, Combination; Female; Gambia; Humans; Malaria, Falciparum; Malawi; Male; Middle Aged; Parasitic Sensitivity Tests; Proguanil; Time Factors | 2009 |
Artemisinin resistance in Plasmodium falciparum malaria.
Topics: Administration, Oral; Adolescent; Adult; Animals; Antimalarials; Artemisinins; Artesunate; Drug Resistance; Drug Therapy, Combination; Follow-Up Studies; Humans; Hypoxanthine; Inhibitory Concentration 50; Malaria, Falciparum; Mefloquine; Multidrug Resistance-Associated Proteins; Plasmodium falciparum; Polymorphism, Genetic; Recurrence; Young Adult | 2009 |
Comparative study of dihydroartemisinin and artesunate safety in healthy Thai volunteers.
Topics: Adult; Antimalarials; Artemisinins; Artesunate; Blood Cell Count; Bone Marrow; Cross-Over Studies; Female; Hemoglobins; Humans; Leukocyte Count; Male; Reticulocytes; Single-Blind Method; Thailand; Young Adult | 2009 |
Population pharmacokinetics of artesunate and dihydroartemisinin following single- and multiple-dosing of oral artesunate in healthy subjects.
Topics: Administration, Oral; Adult; Antimalarials; Artemisinins; Artesunate; Chromatography, Liquid; Eating; Female; Humans; Male; Mass Spectrometry; Models, Statistical; Naphthyridines; Plasma; Republic of Korea; Young Adult | 2009 |
An open-label, randomised study of dihydroartemisinin-piperaquine versus artesunate-mefloquine for falciparum malaria in Asia.
Topics: Adolescent; Adult; Aged; Antimalarials; Artemisinins; Artesunate; Asia; Child; Child, Preschool; Female; Humans; Infant; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Quinolines; Young Adult | 2010 |
Comparative oral bioavailability of non-fixed and fixed combinations of artesunate and amodiaquine in healthy Indian male volunteers.
Topics: Administration, Oral; Adolescent; Adult; Amodiaquine; Analysis of Variance; Antimalarials; Area Under Curve; Artemisinins; Artesunate; Biological Availability; Chromatography, High Pressure Liquid; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Combinations; Drug Therapy, Combination; Humans; India; Male; Middle Aged; Tablets; Tandem Mass Spectrometry; Therapeutic Equivalency; Young Adult | 2011 |
A phase III, randomized, non-inferiority trial to assess the efficacy and safety of dihydroartemisinin-piperaquine in comparison with artesunate-mefloquine in patients with uncomplicated Plasmodium falciparum malaria in southern Laos.
Topics: Adolescent; Adult; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; Laos; Malaria, Falciparum; Male; Mefloquine; Quinolines; Young Adult | 2010 |
Population pharmacokinetics of artesunate and dihydroartemisinin in pregnant and non-pregnant women with malaria.
Topics: Administration, Oral; Adolescent; Adult; Antimalarials; Artemisinins; Artesunate; Case-Control Studies; Democratic Republic of the Congo; Female; Humans; Malaria, Falciparum; Models, Biological; Models, Statistical; Pregnancy; Pregnancy Complications, Parasitic; Young Adult | 2011 |
A simplified intravenous artesunate regimen for severe malaria.
Topics: Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Double-Blind Method; Female; Humans; Kaplan-Meier Estimate; Malaria, Falciparum; Male; Parasite Load; Parasitemia; Time Factors; Treatment Outcome | 2012 |
Drug-drug interaction analysis of pyronaridine/artesunate and ritonavir in healthy volunteers.
Topics: Adolescent; Adult; Antimalarials; Area Under Curve; Artemisinins; Artesunate; Drug Interactions; Female; HIV Protease Inhibitors; Humans; Male; Middle Aged; Naphthyridines; Ritonavir; Young Adult | 2012 |
Pharmacokinetics and pharmacodynamics of intravenous artesunate during severe malaria treatment in Ugandan adults.
Topics: Adult; Antimalarials; Artemisinins; Artesunate; Chromatography, Liquid; Female; Humans; Injections, Intravenous; Malaria; Male; Plasma; Tandem Mass Spectrometry; Uganda | 2012 |
Therapeutic efficacy and safety of dihydroartemisinin-piperaquine versus artesunate-mefloquine in uncomplicated Plasmodium falciparum malaria in India.
Topics: Adolescent; Adult; Aged; Antimalarials; Artemisinins; Artesunate; Asia; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Humans; India; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Quinolines; Treatment Outcome; Young Adult | 2012 |
Pharmacokinetics and pharmacodynamics of oral artesunate monotherapy in patients with uncomplicated Plasmodium falciparum malaria in western Cambodia.
Topics: Administration, Oral; Adult; Antimalarials; Artemisinins; Artesunate; Cambodia; Drug Administration Schedule; Female; Humans; Malaria, Falciparum; Male; Parasitemia; Plasmodium falciparum; Severity of Illness Index | 2012 |
In vivo susceptibility of Plasmodium falciparum to artesunate in Binh Phuoc Province, Vietnam.
Topics: Adolescent; Adult; Antimalarials; Artemisinins; Artesunate; Child; Drug Resistance; Female; Humans; Malaria, Falciparum; Male; Plasmodium falciparum; Quinolines; Treatment Outcome; Vietnam; Young Adult | 2012 |
Randomized, open-label trial of primaquine against vivax malaria relapse in Indonesia.
Topics: Adult; Antimalarials; Artemisinins; Artesunate; Drug Administration Schedule; Drug Dosage Calculations; Drug Resistance; Drug Therapy, Combination; Humans; Indonesia; Malaria; Malaria, Vivax; Male; Military Personnel; Plasmodium vivax; Primaquine; Quinine; Quinolines; Secondary Prevention | 2013 |
Pharmacokinetics of artesunate alone and in combination with sulfadoxine/pyrimethamine in healthy Sudanese volunteers.
Topics: Administration, Oral; Adult; Antimalarials; Artemisinins; Artesunate; Cross-Over Studies; Drug Combinations; Drug Therapy, Combination; Female; Humans; Malaria, Falciparum; Male; Plasmodium falciparum; Pyrimethamine; Sudan; Sulfadoxine; Volunteers; Young Adult | 2014 |
Pharmacokinetic evaluation of intravenous artesunate in adults with uncomplicated falciparum malaria in Kenya: a phase II study.
Topics: Activation, Metabolic; Adult; Aged; Antimalarials; Artemisinins; Artesunate; Atovaquone; Chromatography, Liquid; Drug Combinations; Drug Compounding; Drug Monitoring; Female; Half-Life; Humans; Infusions, Intravenous; Kenya; Malaria, Falciparum; Male; Mass Spectrometry; Middle Aged; Proguanil; Reticulocytes; Young Adult | 2014 |
Population pharmacokinetics of artesunate and dihydroartemisinin during long-term oral administration of artesunate to patients with metastatic breast cancer.
Topics: Administration, Oral; Adult; Aged; Antimalarials; Artemisinins; Artesunate; Breast Neoplasms; Female; Humans; Intestinal Absorption; Middle Aged; Models, Biological; Saliva | 2014 |
Pharmacokinetic interactions between primaquine and pyronaridine-artesunate in healthy adult Thai subjects.
Topics: Administration, Oral; Adult; Antimalarials; Artemisinins; Artesunate; Cross-Over Studies; Drug Interactions; Drug Therapy, Combination; Female; Humans; Malaria, Falciparum; Malaria, Vivax; Male; Middle Aged; Naphthyridines; Primaquine; Thailand; Young Adult | 2015 |
Safe and efficacious artemisinin-based combination treatments for African pregnant women with malaria: a multicentre randomized control trial.
Topics: Adult; Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; Birth Weight; Burkina Faso; Drug Combinations; Ethanolamines; Female; Fetal Development; Fluorenes; Follow-Up Studies; Ghana; Humans; Infant, Newborn; Malaria; Malawi; Mefloquine; Placentation; Pregnancy; Pregnancy Complications, Parasitic; Prenatal Exposure Delayed Effects; Quinolines; Zambia | 2015 |
Opposite malaria and pregnancy effect on oral bioavailability of artesunate - a population pharmacokinetic evaluation.
Topics: Administration, Intravenous; Administration, Oral; Antimalarials; Artemisinins; Artesunate; Biological Availability; Female; Humans; Malaria; Models, Biological; Postpartum Period; Pregnancy; Pregnancy Complications, Parasitic | 2015 |
Artemisinin-based combination therapy in pregnant women in Zambia: efficacy, safety and risk of recurrent malaria.
Topics: Adolescent; Adult; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; Drug Combinations; Ethanolamines; Female; Fluorenes; Humans; Malaria; Mefloquine; Pregnancy; Quinolines; Recurrence; Risk; Treatment Outcome; Young Adult; Zambia | 2017 |
Dihydroartemisinin-piperaquine versus artesunate-amodiaquine for treatment of malaria infection in pregnancy in Ghana: an open-label, randomised, non-inferiority trial.
Topics: Adolescent; Adult; Amodiaquine; Antimalarials; Artemisinins; Artesunate; Female; Humans; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Outcome; Quinolines; Treatment Outcome; Young Adult | 2017 |
Pyronaridine-artesunate or dihydroartemisinin-piperaquine versus current first-line therapies for repeated treatment of uncomplicated malaria: a randomised, multicentre, open-label, longitudinal, controlled, phase 3b/4 trial.
Topics: Adolescent; Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; Child; Child, Preschool; Drug Combinations; Drug Therapy, Combination; Ethanolamines; Female; Fluorenes; Humans; Longitudinal Studies; Malaria; Male; Naphthyridines; Quinolines; Young Adult | 2018 |
Enantiospecific pharmacokinetics and drug-drug interactions of primaquine and blood-stage antimalarial drugs.
Topics: Adult; Antimalarials; Artemisinins; Artesunate; Cross-Over Studies; Drug Interactions; Drug Therapy, Combination; Female; Healthy Volunteers; Humans; Malaria, Vivax; Male; Middle Aged; Primaquine; Quinolines; Thailand; Young Adult | 2018 |
Piperaquine concentration and malaria treatment outcomes in Ugandan children treated for severe malaria with intravenous Artesunate or quinine plus Dihydroartemisinin-Piperaquine.
Topics: Administration, Intravenous; Antimalarials; Artemisinins; Artesunate; Child, Preschool; Female; Follow-Up Studies; Humans; Infant; Malaria, Falciparum; Male; Osmolar Concentration; Plasmodium falciparum; Quinine; Quinolines; Recurrence; Treatment Outcome; Uganda | 2019 |
A randomized controlled trial of dihydroartemisinin-piperaquine, artesunate-mefloquine and extended artemether-lumefantrine treatments for malaria in pregnancy on the Thailand-Myanmar border.
Topics: Antimalarials; Artemether; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; Drug Therapy, Combination; Female; Humans; Infant, Newborn; Malaria; Malaria, Falciparum; Mefloquine; Myanmar; Pregnancy; Premature Birth; Quinolines; Thailand | 2021 |
Effectiveness and safety of intermittent preventive treatment with dihydroartemisinin-piperaquine or artesunate-amodiaquine for reducing malaria and related morbidities in schoolchildren in Tanzania: a randomised controlled trial.
Topics: Amodiaquine; Antimalarials; Artesunate; Child; COVID-19; Drug Combinations; Hemoglobins; Humans; Incidence; Malaria; Malaria, Falciparum; Quinolines; Tanzania | 2023 |
124 other study(ies) available for artenimol and artesunic acid
| Article | Year |
|---|---|
[Pharmacokinetics and metabolism of artesunate in cows].
Topics: Animals; Artemisinins; Artesunate; Cattle; Chromatography, Thin Layer; Female; Sesquiterpenes | 1991 |
Hemolysis induced by artemisinin and its derivatives in vitro.
Topics: Antimalarials; Artemether; Artemisinins; Artesunate; Erythrocytes; Hemoglobins; Hemolysis; Humans; Pyrans; Sesquiterpenes | 1986 |
The chemotherapy of rodent malaria, XL. The action of artemisinin and related sesquiterpenes.
Topics: Animals; Antimalarials; Artemether; Artemisinins; Artesunate; Drug Resistance; Malaria; Male; Mice; Pigments, Biological; Plasmodium berghei; Pyrans; Sesquiterpenes | 1986 |
[A preliminary study on the urinary excretion of artesunate and its metabolites in man after a single intravenous injection].
Topics: Adult; Antimalarials; Artemisinins; Artesunate; Chromatography, High Pressure Liquid; Half-Life; Humans; Injections, Intravenous; Male; Sesquiterpenes | 1987 |
Analysis of artesunic acid and dihydroqinghaosu in blood by high-performance liquid chromatography with reductive electrochemical detection.
Topics: Animals; Artemisinins; Artesunate; Chromatography, High Pressure Liquid; Drug Stability; Electrochemistry; Humans; Hydrolysis; Kinetics; Rabbits; Rats; Rats, Inbred Strains; Sesquiterpenes | 1987 |
[Determination of artesunate and dihydroqinghaosu in human plasma by high performance liquid chromatography with a reductive mode electrochemical detection].
Topics: Antimalarials; Artemisinins; Artesunate; Chromatography, High Pressure Liquid; Humans; Sesquiterpenes | 1985 |
[Studies on the fate of artesunate by GC-MS, HPLC and TLCS methods].
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cytochrome P-450 Enzyme System; Dogs; Gas Chromatography-Mass Spectrometry; Male; Mice; Microsomes, Liver; Rabbits; Rats; Sesquiterpenes | 1985 |
Determination of artesunate and dihydroartemisinine in plasma by liquid chromatography with post-column derivatization and UV-detection.
Topics: Antimalarials; Artemisinins; Artesunate; Chromatography, Liquid; Humans; Sesquiterpenes; Spectrophotometry, Ultraviolet | 1984 |
Clinical trials of artemisinin and its derivatives in the treatment of malaria in China.
Topics: Antimalarials; Antiprotozoal Agents; Artemisinins; Artesunate; China; Clinical Trials as Topic; Humans; Injections, Intramuscular; Injections, Intravenous; Malaria, Cerebral; Malaria, Falciparum; Sesquiterpenes; Suppositories; Tablets | 1994 |
Comparison of in vivo and in vitro antimalarial activity of artemisinin, dihydroartemisinin and sodium artesunate in the Plasmodium berghei-rodent model.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Malaria; Mice; Plasmodium berghei; Rats; Rats, Wistar; Sesquiterpenes | 1994 |
Artemisinin and its derivatives enhance T lymphocyte-mediated immune responses in normal mice and accelerate immunoreconstitution of mice with syngeneic bone marrow transplantation.
Topics: Adjuvants, Immunologic; Analysis of Variance; Animals; Antimalarials; Artemisinins; Artesunate; B-Lymphocytes; Bone Marrow Transplantation; Concanavalin A; DNA; Dose-Response Relationship, Immunologic; Female; Hypersensitivity, Delayed; Immunity, Cellular; Interleukin-2; Lipopolysaccharides; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Sesquiterpenes; Spleen; T-Lymphocytes | 1993 |
Selective high-performance liquid chromatographic determination of artesunate and alpha- and beta-dihydroartemisinin in patients with falciparum malaria.
Topics: Antimalarials; Artemisinins; Artesunate; Chromatography, High Pressure Liquid; Humans; Isomerism; Malaria, Falciparum; Reproducibility of Results; Sesquiterpenes; Spectrophotometry, Ultraviolet | 1996 |
Chemical stability of artesunate injection and proposal for its administration by intravenous infusion.
Topics: Antimalarials; Artemisinins; Artesunate; Chromatography, High Pressure Liquid; Drug Stability; Drug Storage; Half-Life; Infusions, Intravenous; Injections, Intravenous; Reference Standards; Sesquiterpenes; Sodium Chloride; Statistics as Topic; Syringes; Temperature | 1996 |
In vitro stage-specific sensitivity of Plasmodium falciparum to quinine and artemisinin drugs.
Topics: Adult; Animals; Antimalarials; Artemether; Artemisinins; Artesunate; Chloroquine; Drug Evaluation, Preclinical; Drug Resistance; Humans; In Vitro Techniques; Malaria, Falciparum; Male; Middle Aged; Plasmodium falciparum; Quinine; Sesquiterpenes | 1996 |
In vitro susceptibility of Plasmodium falciparum isolates in Vietnam to artemisinin derivatives and other antimalarials.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Chloroquine; Mefloquine; Microbial Sensitivity Tests; Plasmodium falciparum; Quinine; Sesquiterpenes; Vietnam | 1997 |
Simultaneous determination of artesunic acid and dihydroartemisinin in blood plasma by high-performance liquid chromatography for application in clinical pharmacological studies.
Topics: Adult; Antimalarials; Artemisinins; Artesunate; Chromatography, High Pressure Liquid; Humans; Male; Reproducibility of Results; Sensitivity and Specificity; Sesquiterpenes | 1997 |
Pharmacokinetic and bioequivalence evaluation of two generic formulations of oral artesunate.
Topics: Administration, Oral; Adult; Animals; Antimalarials; Artemisinins; Artesunate; Drugs, Generic; Humans; Malaria, Falciparum; Male; Plasmodium falciparum; Sesquiterpenes; Therapeutic Equivalency | 1998 |
Plasma levels of artesunate and dihydroartemisinin in children with Plasmodium falciparum malaria in Gabon after administration of 50-milligram artesunate suppositories.
Topics: Absorption; Antimalarials; Artemisinins; Artesunate; Child; Female; Fever; Gabon; Humans; Malaria, Falciparum; Male; Parasitemia; Sesquiterpenes; Suppositories | 1998 |
In vitro sensitivity of Plasmodium falciparum to eight antimalarials in China-Myanmar and China-Lao PDR border areas.
Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Artesunate; China; Chloroquine; Drug Evaluation, Preclinical; Drug Resistance; Humans; Laos; Microbial Sensitivity Tests; Myanmar; Naphthyridines; Plasmodium falciparum; Quinine; Sesquiterpenes | 1997 |
Simple high-performance liquid chromatographic method with electrochemical detection for the simultaneous determination of artesunate and dihydroartemisinin in biological fluids.
Topics: Adult; Antimalarials; Artemisinins; Artesunate; Chromatography, High Pressure Liquid; Electrochemistry; Humans; Male; Sensitivity and Specificity; Sesquiterpenes | 1998 |
[Contragestational effects of dihydroartemisinin and artesunate].
Topics: Abortifacient Agents, Nonsteroidal; Animals; Artemisinins; Artesunate; Contraceptive Agents, Female; Cricetinae; Embryo Loss; Female; Guinea Pigs; Mice; Mice, Inbred ICR; Pregnancy; Rabbits; Sesquiterpenes; Uterus | 1996 |
The development of an immunoassay for the detection of artemisinin compounds in urine.
Topics: Adult; Antibodies, Monoclonal; Antimalarials; Artemisinins; Artesunate; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Humans; Sesquiterpenes | 1999 |
Effects of artesunate, dihydroartemisinin, and an artesunate-dihydroartemisinin combination against Toxoplasma gondii.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Brain; Cell Line; Cell Survival; Drug Combinations; Female; Histocytochemistry; Humans; Mice; Sesquiterpenes; Toxoplasma; Toxoplasmosis, Animal | 2000 |
Behavioral and neural toxicity of the artemisinin antimalarial, arteether, but not artesunate and artelinate, in rats.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Behavior, Animal; Brain; Brain Stem; Discrimination Learning; Male; Rats; Rats, Sprague-Dawley; Sesquiterpenes | 2000 |
The development of new antimalarial drugs: qinghaosu and dihydro-qinghaosu.
Topics: Animals; Antimalarials; Artemether; Artemisia; Artemisinins; Artesunate; Drugs, Chinese Herbal; Humans; Sesquiterpenes | 1999 |
Authentication of artemether, artesunate and dihydroartemisinin antimalarial tablets using a simple colorimetric method.
Topics: Antimalarials; Artemether; Artemisinins; Artesunate; Colorimetry; Diazonium Compounds; Sesquiterpenes; Tablets | 2001 |
Comparative pharmacokinetics and effect kinetics of orally administered artesunate in healthy volunteers and patients with uncomplicated falciparum malaria.
Topics: Administration, Oral; Adult; Antimalarials; Area Under Curve; Artemisinins; Artesunate; Chromatography, High Pressure Liquid; Humans; Malaria, Falciparum; Male; Sesquiterpenes | 2001 |
[In vitro study of the anti-pneumocystis carinii effect of arteminsin derivatives].
Topics: Animals; Artemisinins; Artesunate; Cell Division; Dose-Response Relationship, Drug; Humans; Pneumocystis; Rats; Rats, Wistar; Sesquiterpenes; Time Factors; Tumor Cells, Cultured | 2001 |
Glucuronidation of dihydroartemisinin in vivo and by human liver microsomes and expressed UDP-glucuronosyltransferases.
Topics: Adult; Antimalarials; Artemisinins; Artesunate; Female; Glucuronides; Glucuronosyltransferase; Humans; In Vitro Techniques; Malaria, Falciparum; Male; Microsomes, Liver; Recombinant Proteins; Sesquiterpenes | 2002 |
Modulation of multidrug resistance by artemisinin, artesunate and dihydroartemisinin in K562/adr and GLC4/adr resistant cell lines.
Topics: Artemisinins; Artesunate; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Drug Resistance, Multiple; Humans; K562 Cells; Membrane Potentials; Mitochondria; Multidrug Resistance-Associated Proteins; Sesquiterpenes; Tumor Cells, Cultured | 2002 |
Inhibition of human cancer cell line growth and human umbilical vein endothelial cell angiogenesis by artemisinin derivatives in vitro.
Topics: Angiogenesis Inhibitors; Artemisinins; Artesunate; Cell Culture Techniques; Cell Line, Tumor; Dose-Response Relationship, Drug; Endothelium, Vascular; Growth Inhibitors; Humans; Neovascularization, Pathologic; Sesquiterpenes; Umbilical Veins | 2003 |
Comparison of bioassay and high performance liquid chromatographic assay of artesunate and dihydroartemisinin in plasma.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Biological Assay; Chromatography, High Pressure Liquid; Humans; Inhibitory Concentration 50; Malaria, Falciparum; Plasmodium falciparum; Sesquiterpenes | 2003 |
Plasmodium falciparum-based bioassay for measurement of artemisinin derivatives in plasma or serum.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Biological Assay; Biotransformation; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Electrochemistry; Hot Temperature; Humans; In Vitro Techniques; Macaca mulatta; Malaria, Falciparum; Plasmodium falciparum; Reproducibility of Results; Sesquiterpenes | 2004 |
Development and validation of a high-performance liquid chromatography-mass spectroscopy assay for determination of artesunate and dihydroartemisinin in human plasma.
Topics: Antimalarials; Artemisinins; Artesunate; Chromatography, High Pressure Liquid; Drug Stability; Freezing; Humans; Mass Spectrometry; Reproducibility of Results; Sesquiterpenes | 2005 |
Pharmacokinetics of dihydroartemisinin following oral artesunate treatment of pregnant women with acute uncomplicated falciparum malaria.
Topics: Acute Disease; Adolescent; Adult; Analysis of Variance; Antimalarials; Artemisinins; Artesunate; Atovaquone; Drug Combinations; Drug Resistance, Multiple; Drug Therapy, Combination; Female; Half-Life; Humans; Malaria, Falciparum; Pregnancy; Pregnancy Complications, Parasitic; Pregnancy Outcome; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Proguanil; Sesquiterpenes; Thailand | 2006 |
Artesunate and artemether are effective fasciolicides in the rat model and in vitro.
Topics: Animals; Antiplatyhelmintic Agents; Artemether; Artemisinins; Artesunate; Bile Ducts; Disease Models, Animal; Fasciola hepatica; Fascioliasis; Female; Microscopy, Electron, Scanning; Rats; Rats, Wistar; Sesquiterpenes | 2006 |
Manslaughter by fake artesunate in Asia--will Africa be next?
Topics: Adult; Africa; Antimalarials; Artemisinins; Artesunate; Asia; Drug and Narcotic Control; Drug Contamination; Drug Costs; Drug Packaging; Fraud; Global Health; Humans; Malaria; Male; Sesquiterpenes; Travel | 2006 |
Artemisinin combination therapies.
Topics: Adult; Africa; Antimalarials; Artemisinins; Artesunate; Asia; Child, Preschool; Drug Therapy, Combination; Humans; Malaria, Falciparum; Mefloquine; Quinolines; Sesquiterpenes | 2006 |
Population pharmacokinetics of artesunate and dihydroartemisinin following intra-rectal dosing of artesunate in malaria patients.
Topics: Administration, Rectal; Adolescent; Adult; Africa; Aging; Antimalarials; Artemisinins; Artesunate; Asia, Southeastern; Child; Child, Preschool; Demography; Female; Humans; Infant; Malaria; Male; Middle Aged; Parasitemia; Salvage Therapy; Sesquiterpenes; Sex Factors; Suppositories; Treatment Outcome | 2006 |
Assessment of the effect of mefloquine on artesunate pharmacokinetics in healthy male volunteers.
Topics: Adult; Antimalarials; Area Under Curve; Artemisinins; Artesunate; Chromatography, High Pressure Liquid; Drug Interactions; Humans; Male; Mefloquine; Middle Aged; Sesquiterpenes; Spectrophotometry, Ultraviolet | 2007 |
Quality control of active ingredients in artemisinin-derivative antimalarials within Kenya and DR Congo.
Topics: Antimalarials; Artemether; Artemisinins; Artesunate; Capsules; Chromatography, High Pressure Liquid; Democratic Republic of the Congo; Dosage Forms; Endemic Diseases; Humans; Kenya; Malaria, Falciparum; Quality Control; Sesquiterpenes; Tablets | 2007 |
In vitro antimalarial drug susceptibility and pfcrt mutation among fresh Plasmodium falciparum isolates from the Lao PDR (Laos).
Topics: Adolescent; Adult; Animals; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Chloroquine; DNA, Protozoan; Drug Resistance; Ethanolamines; Female; Fluorenes; Humans; Inhibitory Concentration 50; Laos; Lumefantrine; Malaria, Falciparum; Male; Mefloquine; Membrane Transport Proteins; Middle Aged; Plasmodium falciparum; Point Mutation; Polymerase Chain Reaction; Protozoan Proteins; Sesquiterpenes | 2007 |
Artesunate and a major metabolite, dihydroartemisinin, diminish mitogen-induced lymphocyte proliferation and activation.
Topics: Adult; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Antimalarials; Artemisinins; Artesunate; Cells, Cultured; Cytokines; Dose-Response Relationship, Drug; Humans; Interleukin-2 Receptor alpha Subunit; Lectins, C-Type; Leukocytes, Mononuclear; Lymphocyte Activation; Mitogens; Phytohemagglutinins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sesquiterpenes | 2006 |
Artesunate and dihydroartemisinin (DHA): unusual decomposition products formed under mild conditions and comments on the fitness of DHA as an antimalarial drug.
Topics: Antimalarials; Artemisinins; Artesunate; Dimerization; Magnetic Resonance Spectroscopy; Suppositories | 2007 |
Optimization of an LC-MS method for the determination of artesunate and dihydroartemisinin plasma levels using liquid-liquid extraction.
Topics: Antimalarials; Artemisinins; Artesunate; Atmospheric Pressure; Chromatography, High Pressure Liquid; Humans; Reproducibility of Results; Sesquiterpenes; Spectrometry, Mass, Electrospray Ionization | 2008 |
Comparison of HPLC with electrochemical detection and LC-MS/MS for the separation and validation of artesunate and dihydroartemisinin in animal and human plasma.
Topics: Animals; Artemisinins; Artesunate; Calibration; Chromatography, High Pressure Liquid; Electrochemistry; Humans; Reproducibility of Results; Tandem Mass Spectrometry | 2008 |
Pharmacokinetics of artesunate in the domestic pig.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Biological Availability; Chromatography, High Pressure Liquid; Half-Life; Humans; Injections, Intra-Arterial; Injections, Intramuscular; Injections, Intravenous; Male; Metabolic Clearance Rate; Plasma; Sus scrofa; Time Factors; Tissue Distribution | 2008 |
Absence of time-dependent artesunate pharmacokinetics in healthy subjects during 5-day oral administration.
Topics: Administration, Oral; Adult; Antimalarials; Area Under Curve; Artemisinins; Artesunate; Drug Administration Schedule; Half-Life; Humans; Male; Metabolic Clearance Rate; Middle Aged; Time; Vietnam; Young Adult | 2008 |
Embryotoxicity of artesunate in animal species related to drug tissue distribution and toxicokinetic profiles.
Topics: Animals; Artemisinins; Artesunate; Autoradiography; Embryo, Mammalian; Female; Injections, Intravenous; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2008 |
Artesunate: developmental toxicity and toxicokinetics in monkeys.
Topics: Animals; Artemisinins; Artesunate; Blood Cell Count; Embryo, Mammalian; Female; Fetus; Haplorhini; Hemodynamics; Myocardium; Pregnancy; Prenatal Exposure Delayed Effects | 2008 |
Experimental therapy of hepatoma with artemisinin and its derivatives: in vitro and in vivo activity, chemosensitization, and mechanisms of action.
Topics: Animals; Antineoplastic Agents; Artemether; Artemisinins; Artesunate; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Humans; Liver; Liver Neoplasms; Mice; Mice, Nude; Xenograft Model Antitumor Assays | 2008 |
A liquid chromatographic-tandem mass spectrometric method for determination of artesunate and its metabolite dihydroartemisinin in human plasma.
Topics: Artemisinins; Artesunate; Chromatography, Liquid; Humans; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Uncertainty | 2008 |
Development and validation of a liquid chromatography-mass spectrometry method for the simultaneous quantification of artesunate and dihydroartemisinin in human plasma.
Topics: Antimalarials; Area Under Curve; Artemisinins; Artesunate; Chromatography, Liquid; Half-Life; Humans; Mass Spectrometry; Metabolic Clearance Rate; Sensitivity and Specificity | 2008 |
Pharmacokinetic parameters of artesunate and dihydroartemisinin in rats infected with Fasciola hepatica.
Topics: Animals; Anthelmintics; Area Under Curve; Artemisinins; Artesunate; Chromatography, Liquid; Fasciola hepatica; Fascioliasis; Female; Mass Spectrometry; Plasma; Rats | 2009 |
Effects of artemisinin derivative on the growth metabolism of Tetrahymena thermophila BF5 based on expression of thermokinetics.
Topics: Animals; Artemisinins; Artesunate; Calorimetry; Tetrahymena thermophila | 2010 |
Severe congenital malaria acquired in utero.
Topics: Adult; Antimalarials; Artemisinins; Artesunate; Female; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Malaria, Falciparum; Pregnancy; Quinolines | 2010 |
Localization of artesunate and its derivatives in the pregnant rat and fetus following oral administration and relationship to developmental toxicity.
Topics: Administration, Oral; Animals; Antimalarials; Artemisinins; Artesunate; Autoradiography; Dapsone; Female; Fetus; Male; Pregnancy; Proguanil; Random Allocation; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2010 |
A simplified liquid chromatography-mass spectrometry assay for artesunate and dihydroartemisinin, its metabolite, in human plasma.
Topics: Antimalarials; Artemisinins; Artesunate; Chromatography, Liquid; Humans; Mass Spectrometry; Plasma; Sensitivity and Specificity; Time Factors | 2010 |
The multiple-dosing pharmacokinetics of artemether, artesunate, and their metabolite dihydroartemisinin in rats.
Topics: Administration, Oral; Animals; Antimalarials; Artemether; Artemisinins; Artesunate; Male; Rats; Rats, Wistar | 2011 |
Development and validation of a liquid chromatography and ion spray tandem mass spectrometry method for the quantification of artesunate, artemether and their major metabolites dihydroartemisinin and dihydroartemisinin-glucuronide in sheep plasma.
Topics: Animals; Artemether; Artemisinins; Artesunate; Calibration; Chromatography, Liquid; Chromatography, Reverse-Phase; Glucuronides; Logistic Models; Reproducibility of Results; Sensitivity and Specificity; Sheep; Tandem Mass Spectrometry | 2011 |
Pharmacokinetics and pharmacodynamics of artesunate and dihydroartemisinin following oral treatment in pregnant women with asymptomatic Plasmodium falciparum infections in Kinshasa DRC.
Topics: Adolescent; Adult; Antimalarials; Artemisinins; Artesunate; Asymptomatic Infections; Chromatography, Liquid; Democratic Republic of the Congo; Female; Humans; Infant, Newborn; Malaria, Falciparum; Mass Spectrometry; Plasma; Plasmodium falciparum; Pregnancy; Pregnancy Complications, Infectious; Young Adult | 2011 |
Effects of artemether, artesunate and dihydroartemisinin administered orally at multiple doses or combination in treatment of mice infected with Schistosoma japonicum.
Topics: Administration, Oral; Animals; Antiprotozoal Agents; Artemether; Artemisinins; Artesunate; Disease Models, Animal; Female; Mice; Rodent Diseases; Schistosoma japonicum; Schistosomiasis japonica; Treatment Outcome | 2011 |
Artesunate/dihydroartemisinin pharmacokinetics in acute falciparum malaria in pregnancy: absorption, bioavailability, disposition and disease effects.
Topics: Adolescent; Adult; Antimalarials; Artemisinins; Artesunate; Biological Availability; Dose-Response Relationship, Drug; Female; Humans; Malaria, Falciparum; Metabolic Clearance Rate; Postpartum Period; Pregnancy; Pregnancy Complications, Parasitic; Severity of Illness Index; Young Adult | 2012 |
Characterization of dihydroartemisinin-resistant colon carcinoma HCT116/R cell line.
Topics: Annexins; Antineoplastic Agents; Apoptosis; Artemisinins; Artesunate; Carcinoma; Cell Cycle Checkpoints; Cell Proliferation; Colonic Neoplasms; Drug Resistance, Neoplasm; Gene Expression; HCT116 Cells; Heat-Shock Proteins; Humans; Phosphopyruvate Hydratase; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2012 |
In vitro sensitivity of Plasmodium falciparum from China-Myanmar border area to major ACT drugs and polymorphisms in potential target genes.
Topics: Antimalarials; Artemisinins; Artesunate; Calcium-Transporting ATPases; China; Drug Resistance; Ethanolamines; Fluorenes; Lumefantrine; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Myanmar; Plasmodium falciparum; Polymorphism, Genetic; Protozoan Proteins | 2012 |
Assessing the consistency assumption by exploring treatment by covariate interactions in mixed treatment comparison meta-analysis: individual patient-level covariates versus aggregate trial-level covariates.
Topics: Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; Dapsone; Drug Combinations; Ethanolamines; Fluorenes; Humans; Malaria; Meta-Analysis as Topic; Models, Statistical; Outcome Assessment, Health Care; Proguanil; Quinolines; Regression Analysis | 2012 |
Artesunate- and amodiaquine-associated extrapyramidal reactions: a series of 49 cases in VigiBase™.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Africa; Amodiaquine; Antimalarials; Artemisinins; Artesunate; Basal Ganglia Diseases; Child; Child, Preschool; Databases, Factual; Drug Therapy, Combination; Female; Humans; Infant; Male; Young Adult | 2012 |
Comparative ex vivo activity of novel endoperoxides in multidrug-resistant plasmodium falciparum and P. vivax.
Topics: Adamantane; Amodiaquine; Antimalarials; Artemisinins; Artesunate; Chloroquine; Drug Resistance, Multiple; Heterocyclic Compounds, 1-Ring; Microbial Sensitivity Tests; Peroxides; Plasmodium falciparum; Plasmodium vivax; Quinolines; Spiro Compounds | 2012 |
Assessing the utility of an anti-malarial pharmacokinetic-pharmacodynamic model for aiding drug clinical development.
Topics: Animals; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; Dose-Response Relationship, Drug; Drug Combinations; Drug Discovery; Ethanolamines; Fluorenes; Host-Pathogen Interactions; Humans; Malaria, Falciparum; Mefloquine; Models, Statistical; Plasmodium falciparum; Quinolines | 2012 |
Optimizing the HRP-2 in vitro malaria drug susceptibility assay using a reference clone to improve comparisons of Plasmodium falciparum field isolates.
Topics: Antigens, Protozoan; Antimalarials; Artemisinins; Artesunate; Chromatography, Liquid; Culture Media; Humans; Inhibitory Concentration 50; Malaria, Falciparum; Mass Spectrometry; Parasitic Sensitivity Tests; Plasmodium falciparum; Protozoan Proteins | 2012 |
Effect of single nucleotide polymorphisms in cytochrome P450 isoenzyme and N-acetyltransferase 2 genes on the metabolism of artemisinin-based combination therapies in malaria patients from Cambodia and Tanzania.
Topics: Alleles; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; Arylamine N-Acetyltransferase; Base Sequence; Cambodia; Cytochrome P-450 Enzyme System; Drug Combinations; Ethanolamines; Fluorenes; Gene Frequency; Humans; Isoenzymes; Malaria; Mefloquine; Pharmacogenetics; Polymorphism, Single Nucleotide; Quinolines; Sequence Analysis, DNA; Tanzania | 2013 |
Population pharmacokinetics of intramuscular artesunate in African children with severe malaria: implications for a practical dosing regimen.
Topics: Antimalarials; Artemisinins; Artesunate; Body Weight; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Infant; Injections, Intramuscular; Malaria, Falciparum; Models, Biological; Nonlinear Dynamics; Severity of Illness Index; Tanzania; Time Factors; Tissue Distribution | 2013 |
Safety and efficacy field study of artesunate for dogs with non-resectable tumours.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Carcinoma, Squamous Cell; Cell Proliferation; Dog Diseases; Dogs; Lymphoma; Mouth Neoplasms; Treatment Outcome; Tumor Cells, Cultured | 2013 |
Differential interactions of the broad spectrum drugs artemisinin, dihydroartemisinin and artesunate with serum albumin.
Topics: Animals; Artemisinins; Artesunate; Cattle; Drug Therapy, Combination; Hydrophobic and Hydrophilic Interactions; Malaria; Protein Binding; Serum Albumin | 2013 |
LC-MS/MS method for the simultaneous quantitation of three active components derived from a novel prodrug against schistosome infection.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Chromatography, Liquid; Female; Male; Prodrugs; Rats; Rats, Sprague-Dawley; Schistosoma; Schistosomiasis; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2013 |
Pharmacokinetic modelling of the anti-malarial drug artesunate and its active metabolite dihydroartemisinin.
Topics: Adult; Antimalarials; Artemisinins; Artesunate; Computer Simulation; Humans; Malaria, Falciparum; Mathematical Concepts; Models, Biological | 2013 |
Effects of body size and gender on the population pharmacokinetics of artesunate and its active metabolite dihydroartemisinin in pediatric malaria patients.
Topics: Administration, Oral; Adult; Age Factors; Antimalarials; Artemisinins; Artesunate; Body Size; Body Weight; Child; Child, Preschool; Computer Simulation; Drug Administration Schedule; Drug Dosage Calculations; Female; Half-Life; Humans; Malaria, Falciparum; Male; Microbial Sensitivity Tests; Models, Statistical; Plasmodium falciparum; Sex Factors | 2013 |
Erythrophagocytosis enhances heme-dependent cytotoxicity of antimalarial drugs in canine histiocytic sarcoma cell line DH82.
Topics: Animals; Antimalarials; Antineoplastic Agents; Artemisinins; Artesunate; Cell Line, Tumor; Cytophagocytosis; Dogs; Erythrocytes; Heme; Histiocytic Sarcoma | 2014 |
Validation of ELISA for quantitation of artemisinin-based antimalarial drugs.
Topics: Antimalarials; Artemether; Artemisinins; Artesunate; Chromatography, High Pressure Liquid; Confidence Intervals; Counterfeit Drugs; Enzyme-Linked Immunosorbent Assay | 2013 |
[Treatment of severe and uncomplicated falciparum malaria in children in France].
Topics: Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; Atovaquone; Child; Drug Combinations; Ethanolamines; Fluorenes; France; Humans; Malaria, Falciparum; Proguanil; Quinolines | 2013 |
Evidence for pyronaridine as a highly effective partner drug for treatment of artemisinin-resistant malaria in a rodent model.
Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Artesunate; Drug Combinations; Drug Resistance; Female; Flow Cytometry; Malaria, Falciparum; Mefloquine; Mice; Naphthyridines | 2014 |
Effects of artemisinin antimalarials on Cytochrome P450 enzymes in vitro using recombinant enzymes and human liver microsomes: potential implications for combination therapies.
Topics: Antimalarials; Artemether; Artemisinins; Artesunate; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Evaluation, Preclinical; Drug Interactions; Humans; Inhibitory Concentration 50; Microsomes, Liver; Recombinant Proteins; Tandem Mass Spectrometry | 2014 |
Development of a colloidal gold-based lateral flow dipstick immunoassay for rapid qualitative and semi-quantitative analysis of artesunate and dihydroartemisinin.
Topics: Animals; Antibodies, Monoclonal; Antimalarials; Artemisinins; Artesunate; Cattle; Chemistry Techniques, Analytical; Counterfeit Drugs; Enzyme-Linked Immunosorbent Assay; Goats; Gold Colloid; Immunoglobulin G; Mice; Serum Albumin; Time Factors | 2014 |
LC-MS/MS method for the simultaneous quantification of artesunate and its metabolites dihydroartemisinin and dihydroartemisinin glucuronide in human plasma.
Topics: Antimalarials; Artemisinins; Artesunate; Chromatography, Liquid; Glucuronides; Humans; Tandem Mass Spectrometry | 2014 |
Ex vivo activity of endoperoxide antimalarials, including artemisone and arterolane, against multidrug-resistant Plasmodium falciparum isolates from Cambodia.
Topics: Antimalarials; Artemisinins; Artesunate; Cambodia; Chloroquine; Heterocyclic Compounds, 1-Ring; Parasitic Sensitivity Tests; Peroxides; Plasmodium falciparum; Spiro Compounds | 2014 |
Interspecies allometric scaling of antimalarial drugs and potential application to pediatric dosing.
Topics: Age Factors; Antimalarials; Artemether; Artemisinins; Artesunate; Child; Child, Preschool; Female; Humans; Male; Models, Theoretical | 2014 |
Inhibition of metalloproteinase-9 secretion and gene expression by artemisinin derivatives.
Topics: Artemisinins; Artesunate; Cytokines; Gene Expression Regulation; Humans; Inflammation Mediators; Malaria, Cerebral; Malaria, Falciparum; Matrix Metalloproteinase 9; Monocytes; Plasmodium falciparum; Polymerase Chain Reaction; RNA, Messenger | 2014 |
Effect of fluorescent dyes on in vitro-differentiated, late-stage Plasmodium falciparum gametocytes.
Topics: Antimalarials; Artemisinins; Artesunate; Carbocyanines; Erythrocytes; Fluorescent Dyes; Gametogenesis; Humans; Inhibitory Concentration 50; Life Cycle Stages; Luminescent Measurements; Malaria, Falciparum; Mitochondria; Plasmodium falciparum; Rhodamines | 2014 |
A high-throughput LC-MS/MS assay for quantification of artesunate and its metabolite dihydroartemisinin in human plasma and saliva.
Topics: Analytic Sample Preparation Methods; Artemisinins; Artesunate; Blood Chemical Analysis; Calibration; Chromatography, Liquid; Drug Stability; Humans; Saliva; Stereoisomerism; Tandem Mass Spectrometry; Temperature; Time Factors | 2014 |
[Therapeutic effect of 138 imported falciparum malaria patients].
Topics: Adult; Africa; Antimalarials; Artemether; Artemisinins; Artesunate; China; Diagnostic Errors; Drug Therapy, Combination; Female; Humans; Malaria, Falciparum; Male; Middle Aged; Plasmodium falciparum; Retrospective Studies; Travel; Young Adult | 2014 |
Synthesis, characterization and in vitro evaluation of a series of novel polyrotaxane-based delivery system for artesunate.
Topics: Antineoplastic Agents; Artemisinins; Artesunate; Calorimetry, Differential Scanning; Cell Line, Tumor; Colonic Neoplasms; Cyclodextrins; Drug Delivery Systems; Drug Evaluation; Humans; Magnetic Resonance Imaging; Poloxamer; Rotaxanes; X-Ray Diffraction | 2015 |
How Robust Are Malaria Parasite Clearance Rates as Indicators of Drug Effectiveness and Resistance?
Topics: Adult; Antimalarials; Artemisinins; Artesunate; Child; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Drug Dosage Calculations; Drug Resistance; Humans; Immunity, Innate; Malaria, Falciparum; Mefloquine; Models, Statistical; Parasitemia; Parasitic Sensitivity Tests; Plasmodium falciparum; Quinolines; Treatment Outcome | 2015 |
NO-Donor Dihydroartemisinin Derivatives as Multitarget Agents for the Treatment of Cerebral Malaria.
Topics: Animals; Antimalarials; Artemether; Artemisinins; Artesunate; Chemistry Techniques, Synthetic; Malaria, Cerebral; Mice; Molecular Targeted Therapy; Muscle Relaxation; Nitric Oxide Donors; Plasmodium berghei; Rats; Vasodilator Agents | 2015 |
Genetic Transformation of Artemisia carvifolia Buch with rol Genes Enhances Artemisinin Accumulation.
Topics: Agrobacterium tumefaciens; Antimalarials; Artemether; Artemisia annua; Artemisinins; Artesunate; Base Sequence; Biosynthetic Pathways; Gene Expression Regulation, Plant; Molecular Sequence Data; Plant Proteins; Plants, Genetically Modified; Transformation, Genetic; Trichomes | 2015 |
UK malaria treatment guidelines 2016.
Topics: Adult; Antimalarials; Artemisinins; Artesunate; Breast Feeding; Child; Child, Preschool; Female; Humans; Malaria; Malaria, Falciparum; Malaria, Vivax; Plasmodium falciparum; Plasmodium vivax; Pregnancy; Pregnancy Complications, Parasitic; Primaquine; Travel | 2016 |
Application of an LC-MS/MS method for reliable determination of amodiaquine, N-desethylamodiaquine, artesunate and dihydroartemisinin in human plasma for a bioequivalence study in healthy Indian subjects.
Topics: Amodiaquine; Artemisinins; Artesunate; Chromatography, Liquid; Humans; India; Tandem Mass Spectrometry; Therapeutic Equivalency | 2016 |
Artemisinin and its derivatives can significantly inhibit lung tumorigenesis and tumor metastasis through Wnt/β-catenin signaling.
Topics: A549 Cells; Animals; Antimalarials; Artemisinins; Artesunate; beta Catenin; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Female; Humans; Lung Neoplasms; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; RNA Interference; Wnt Signaling Pathway; Xenograft Model Antitumor Assays | 2016 |
Evaluation of artemisinins for the treatment of acute myeloid leukemia.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Artemisinins; Artesunate; Cell Line, Tumor; Cell Survival; Cytarabine; High-Throughput Screening Assays; Humans; Leukemia, Myeloid, Acute; Lysosomes; Mice, Inbred Strains; Reactive Oxygen Species; Xenograft Model Antitumor Assays | 2016 |
Absence of Association between Polymorphisms in the RING E3 Ubiquitin Protein Ligase Gene and Ex Vivo Susceptibility to Conventional Antimalarial Drugs in Plasmodium falciparum Isolates from Dakar, Senegal.
Topics: Antimalarials; Artemisinins; Artesunate; Chloroquine; Doxycycline; Ethanolamines; Fluorenes; Lumefantrine; Mefloquine; Naphthyridines; Plasmodium falciparum; Polymorphism, Genetic; Quinine; Quinolines; Senegal; Ubiquitin-Protein Ligases | 2016 |
Highly active ozonides selected against drug resistant malaria.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Chloroquine; Disease Models, Animal; Female; Humans; Malaria, Falciparum; Mefloquine; Mice; Parasitemia; Plasmodium falciparum | 2016 |
Association between Polymorphisms in the Pf
Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Asparagine; ATP-Binding Cassette Transporters; Chloroquine; Doxycycline; Drug Resistance; Ethanolamines; Fluorenes; Gene Expression; Humans; Inhibitory Concentration 50; Lumefantrine; Malaria, Falciparum; Mefloquine; Naphthyridines; Plasmodium falciparum; Polymorphism, Genetic; Protein Isoforms; Protozoan Proteins; Quinine; Quinolines; Repetitive Sequences, Amino Acid; Senegal | 2017 |
Quantification of artesunate and its metabolite, dihydroartemisinin, in animal products using liquid chromatography-tandem mass spectrometry.
Topics: Animals; Artemia; Artemisinins; Artesunate; Chromatography, Liquid; Eels; Fishes; Molecular Conformation; Swine; Tandem Mass Spectrometry | 2018 |
Topics: Antimalarials; Artemisinins; Artesunate; Computer Simulation; Drug Resistance; Drug Therapy, Combination; Humans; Malaria, Falciparum; Mefloquine; Models, Biological; Plasmodium falciparum; Quinolines; Treatment Failure | 2018 |
Cryptic severe
Topics: Administration, Intravenous; Administration, Oral; Antimalarials; Artemisinins; Artesunate; Humans; Italy; Malaria, Falciparum; Male; Middle Aged; Morocco; Plasmodium falciparum; Quinolines; Transients and Migrants; Treatment Outcome | 2018 |
[Descriptive study of malaria cases in the paediatric population in a reference hospital in Valencia, Spain, between 1993 and 2015].
Topics: Adolescent; Age Distribution; Antimalarials; Artemisinins; Artesunate; Atovaquone; Child; Child, Preschool; Drug Combinations; Equatorial Guinea; Female; Hospitals, Community; Humans; Infant; Malaria; Male; Proguanil; Quinine; Quinolines; Retrospective Studies; Sex Distribution; Spain; Symptom Assessment | 2020 |
Artemisinin and its derivatives prevent Helicobacter pylori-induced gastric carcinogenesis via inhibition of NF-κB signaling.
Topics: Animals; Anticarcinogenic Agents; Artemisinins; Artesunate; Bacterial Adhesion; Cell Line, Tumor; Cytokines; Helicobacter Infections; Helicobacter pylori; Humans; Mice, Inbred C57BL; Microbial Sensitivity Tests; NF-kappa B; Reactive Oxygen Species; Stomach Neoplasms | 2019 |
Artesunate enhances the immune response of rabies vaccine as an adjuvant.
Topics: Adjuvants, Immunologic; Animals; Antibodies, Neutralizing; Antibodies, Viral; Artemisinins; Artesunate; Female; Injections, Intramuscular; Mice; Rabies; Rabies Vaccines; Rabies virus; Vaccination; Vaccines, Inactivated; Viral Load | 2019 |
Regulated rutin co-administration reverses mitochondrial-mediated apoptosis in Plasmodium berghei-infected mice.
Topics: Animals; Apoptosis; Artemisinins; Artesunate; Drug Therapy, Combination; Malaria, Falciparum; Male; Mefloquine; Mice; Mitochondria; Plasmodium berghei; Rutin | 2020 |
Intravenous artesunate plus oral dihydroartemisinin-piperaquine or intravenous quinine plus oral quinine for optimum treatment of severe malaria: lesson learnt from a field hospital in Timika, Papua, Indonesia.
Topics: Administration, Intravenous; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Drug Combinations; Female; Humans; Indonesia; Infant; Infant, Newborn; Malaria; Male; Middle Aged; Quinine; Quinolines; Retrospective Studies; Young Adult | 2019 |
Impact of the first-line treatment shift from dihydroartemisinin/piperaquine to artesunate/mefloquine on Plasmodium vivax drug susceptibility in Cambodia.
Topics: Antimalarials; Artemisinins; Artesunate; Cambodia; DNA Copy Number Variations; Drug Resistance; Humans; Malaria, Vivax; Mefloquine; Pharmaceutical Preparations; Plasmodium falciparum; Plasmodium vivax; Protozoan Proteins; Quinolines | 2020 |
Efficacy of dihydroartemisinin/piperaquine and artesunate monotherapy for the treatment of uncomplicated Plasmodium falciparum malaria in Central Vietnam.
Topics: Antimalarials; Artemisinins; Artesunate; Humans; Malaria, Falciparum; Plasmodium falciparum; Quinolines; Vietnam | 2020 |
Leishmania amazonensis response to artemisinin and derivatives.
Topics: Animals; Artemether; Artemisinins; Artesunate; Disease Models, Animal; Female; Leishmania mexicana; Mice; Mice, Inbred BALB C; Parasite Load; Trypanocidal Agents | 2021 |
Predicting the Disposition of the Antimalarial Drug Artesunate and Its Active Metabolite Dihydroartemisinin Using Physiologically Based Pharmacokinetic Modeling.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Bayes Theorem; Models, Biological; Rats | 2021 |
Effect of Body Weight and Age on the Pharmacokinetics of Dihydroartemisinin: Food and Drug Administration Basis for Dose Determination of Artesunate for Injection in Pediatric Patients With Severe Malaria.
Topics: Antimalarials; Artemisinins; Artesunate; Body Weight; Child; Humans; Malaria; Malaria, Falciparum; United States; United States Food and Drug Administration | 2021 |
Artesunate and Dihydroartemisinin Inhibit Rabies Virus Replication.
Topics: Animals; Artemisinins; Artesunate; Mice; Rabies; Rabies virus; Virus Replication | 2021 |
Artemisinin derivatives inhibit adipogenic differentiation of 3T3-L1 preadipocytes through upregulation of CHOP.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Artemisinins; Artesunate; CCAAT-Enhancer-Binding Protein-alpha; CCAAT-Enhancer-Binding Proteins; Down-Regulation; Fatty Acid-Binding Proteins; Gene Expression Regulation; Lipid Metabolism; Mice; Perilipin-1; PPAR gamma; Real-Time Polymerase Chain Reaction; RNA-Seq; RNA, Small Interfering; Transcription Factor CHOP; Up-Regulation | 2021 |
Murine pharmacokinetics and antimalarial pharmacodynamics of dihydroartemisinin trimer self-assembled nanoparticles.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Malaria; Mice; Nanoparticles; Plasmodium yoelii; Rats | 2021 |
Dihydroartemisinin and artesunate inhibit aerobic glycolysis via suppressing c-Myc signaling in non-small cell lung cancer.
Topics: Animals; Artemisinins; Artesunate; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Glucose; Glycolysis; Lung Neoplasms; Mice; Proto-Oncogene Proteins c-myc; Signal Transduction | 2022 |
Artesunate and dihydroartemisinin-piperaquine treatment failure in a severe Plasmodium falciparum malaria case imported from Republic of Côte d'Ivoire.
Topics: Aged; Antimalarials; Artemisinins; Artesunate; Cote d'Ivoire; Drug Combinations; Humans; Malaria; Malaria, Falciparum; Male; Piperazines; Plasmodium falciparum; Quinolines; Treatment Failure | 2022 |
Naturally Acquired Kelch13 Mutations in Plasmodium falciparum Strains Modulate
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Drug Resistance; Drug Tolerance; Hyperoxia; Malaria, Falciparum; Mutation; Parasites; Plasmodium falciparum; Protozoan Proteins | 2022 |
Exploring the Potential Mechanism of Artemisinin and Its Derivatives in the Treatment of Osteoporosis Based on Network Pharmacology and Molecular Docking.
Topics: Artemether; Artemisinins; Artesunate; Caspase 3; Drugs, Chinese Herbal; ErbB Receptors; Humans; Interleukin-17; Mitogen-Activated Protein Kinase 14; Molecular Docking Simulation; Network Pharmacology; Osteoporosis; Prolactin | 2022 |
Artemisinin derivatives induce oxidative stress leading to DNA damage and caspase-mediated apoptosis in Theileria annulata-transformed cells.
Topics: Animals; Apoptosis; Artemisinins; Artesunate; Caspases; Cattle; DNA Damage; Oxidative Stress; Reactive Oxygen Species; Theileria annulata | 2023 |
Variation in neutrophil levels and artemisinin-based combination therapy efficacy in West-Africa.
Topics: Africa; Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; Drug Combinations; Ethanolamines; Humans; Malaria; Malaria, Falciparum; Neutropenia; Neutrophils; Parasitemia; Plasmodium falciparum; Prospective Studies | 2023 |
Targeting HSP70 chaperones by rhein sensitizes liver cancer to artemisinin derivatives.
Topics: Artemisinins; Artesunate; Endoplasmic Reticulum Chaperone BiP; HSC70 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; HSP72 Heat-Shock Proteins; Humans; Liver Neoplasms; Luciferases; Molecular Chaperones | 2024 |