Page last updated: 2024-08-25

artemotil and sesquiterpenes

artemotil has been researched along with sesquiterpenes in 90 studies

Research

Studies (90)

Timeframe	Studies, this research(%)	All Research%
pre-1990	7 (7.78)	18.7374
1990's	51 (56.67)	18.2507
2000's	30 (33.33)	29.6817
2010's	2 (2.22)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Leskovac, V; Peggins, JO	1
Breckenridge, A; Edwards, G; Ward, S	1
Breckenridge, AM; Edwards, G; Wanwimolruk, S; Ward, SA	1
Jiang, HJ; Li, Y; Mei, JY; Xiao, SH; Yin, JW; You, JQ	1
Beauté-Lafitte, A; Caillard, V; Chabaud, AG; Landau, I	1
Leskovac, V; Theoharides, AD	2
Baker, JK; Chi, HT; Hufford, CD; Lee, IS; McChesney, JD; Ramu, K; Zeng, YL	1
Jiang, HJ; Li, Y; Xiao, SH; Yang, YQ; Yin, JW	1
Brewer, TG; Melendez, V; Peggins, JO; Theoharides, AD	1
Dutta, GP; Tripathi, R; Vishwakarma, RA	4
Hufford, CD; Lee, IS	1
Ayalp, A; Bishop, SJ; el-Feraly, FS; Tawfik, AF	1
Baker, JK; Chi, HT; ElSohly, HN; Hufford, CD; Lee, IS	1
ElSohly, HN; Hufford, CD; Lee, IS	1
Brossi, A; Dominguez, L; Flippen-Anderson, JL; George, C; Gilardi, R; Yu, QS	1
Bajpai, R; Dutta, GP; Kar, K; Nath, A; Vishwakarma, RA	1
Baker, JK; ElSohly, HN; Hufford, CD; Lee, IS; McChesney, JD; Yarber, RH	1
Breckenridge, AM; Edwards, G; Idowu, OR; Orme, ML; Ward, SA	1
Flanagan, DR; Krishna, AK	1
Chang, HR; Pechère, JC	1
Brossi, A; Buchs, P; Dominguez Gerpe, L; Flippen-Anderson, JL; Luo, XD; Milhous, W; Peters, W; Venugopalan, B; Yeh, HJ	1
Brewer, TG; Genovese, RF; Petras, JM	1
Baker, JK; Ramu, K	2
Brewer, TG; Grate, SJ; Heiffer, MH; Levine, BS; Peggins, JO; Petras, JM; Schuster, BG; Weina, PJ	1
Asawamahasakda, W; Ittarat, I; Meshnick, SR; Pu, YM; Ziffer, H	1
Brewer, TG; Grate, SJ; Heiffer, MH; Levine, BS; Peggins, JO; Petras, JM; Schuster, BG; Swearengen, J; Weina, PJ	1
Davidson, DE	1
Kager, PA; Schultz, MJ; van Boxtel, CJ; van den Berg, B; Zijlstra, EE	1
Ager, AL; Oh, CH; Posner, GH; Rossan, RN; Webster, HK	1
Baker, JK; Chi, HT; McChesney, JD	1
O'Brien, L; Sherman, IW; Zidovetzki, R	1
Basco, LK; Le Bras, J	1
Ager, AL; Canfield, CJ; Heiffer, MH; Klayman, DL; Kyle, DE; Milhous, WK; Rossan, RN; Schuster, BG; Shmuklarsky, MJ; Tang, DB	1
Dutta, GP; Ghosh, PK; Gupta, S; Vishwakarma, RA	1
Khan, AM; Mahanta, J; Mohapatra, PK; Prakash, A; Srivastava, VK	1
Hossler, P; Kamchonwongpaisan, S; McKeever, P; Meshnick, SR; Ziffer, H	1
Boulard, Y; Caillard, V; Fleck, SL; Glénat, C; Landau, I; Peters, W; Robinson, BL; Thévin, F	1
Bauman, RA; Brewer, TG; Corcoran, KD; Gettayacamin, M; Kyle, DE; Peggins, JO; Petras, JM; Vane, MA; Webster, HK; Young, GD	2
Aguilar, T; Brewer, TG; Grace, JM; Leo, KU; Li, Q; Mitchell, AL; Peggins, J	1
Adak, T; Asthana, OP; Biswas, S; Gupta, S; Sharma, A; Sharma, VP; Usha, D; Valecha, N	1
Farina, C; Goglio, A; Olliaro, P	1
Brewer, TG; Genovese, RF; Li, Q; Newman, DB; Peggins, JO	1
Brewer, TG; Fleckenstein, LL; Heiffer, MH; Li, QG; Masonic, K; Peggins, JO	1
Aguilar, AJ; Brewer, TG; Grace, JM; Peggins, JO; Trotman, KM	1
Dong, Y; Huang, KG; Liao, MZ; Liu, DQ; Yang, HL; Yang, PF; Yang, YM; Zhang, CY	1
Brewer, TG; Genovese, RF; Newman, DB; Petras, JM	1
Dutta, GP; Gupta, S; Vishwakarma, RA	1
Asthana, OP; Sharma, VP; Shukla, MM; Singh, N	1
Brewer, TG; Genovese, RF; Li, Q; Newman, DB	1
McLean, WG; Ward, SA	1
Looareesuwan, S; Wilairatana, P	1
Pandey, VC; Siddiqi, NJ	1
Brewer, TG; Genovese, RF; Gordon, KA; Newman, DB	1
Brewer, TG; Genovese, RF; Newman, DB	1
Bhattacharya, AK; Jain, DC; Khanuja, SP; Kumar, S; Santha Kumar, TR; Sharma, RP; Srivastava, S	1
Bhat, GJ; Biemba, G; Gordeuk, VR; Lugt, CB; Mabeza, GF; Oosterhuis, B; Osborne, C; Peeters, PA; Shakankale, GM; Thuma, PE	1
Mishra, SK; Mohanty, S	1
Alhomida, AS; Pandey, VC; Puri, SK; Siddiqi, NJ; Srivastava, S	1
Genovese, RF; Mog, SR; Nguyen, HA	1
Thatte, UM	1
Asthana, OP; Balsara, AB; Dash, B; Gupta, S; Kamboj, VP; Mahanta, J; Mahapatra, KM; Mahapatra, PK; Mishra, SK; Mohanty, S; Nayak, NC; Pande, TK; Satpathy, SK; Sharma, VP; Shukla, MM; Singh, N; Srivastava, JS; Srivastava, VK; Valecha, N; Vishwanathan, KA	1
Krudsood, S; Looareesuwan, S; Lugt, ChB; Oosterhuis, B; Peeters, PA; Peggins, JO; Schilizzi, BM; Sollie, FA; Wilairatana, P	1
Asthana, OP; Balsara, AB; Das, BS; Dash, B; Dev, V; Gupta, N; Mahapatra, KM; Mandal, OP; Mishra, SK; Mohanty, S; Nayak, NC; Pandey, TK; Patnaik, JK; Sathpathy, S; Sathpathy, SK; Srivastava, JS; Vishwanathan, KA	1
Damle, RK; Shukla, MM; Shukla, UK; Singh, N	1
Yeates, RA	1
Asthana, OP; Das Gupta, P; Srivastava, JS	1
Bauer, R; Efferth, T; Olbrich, A	1
Gettayacamin, M; Kyle, DE; Li, QG; Milhous, WK; Mog, SR; Si, YZ	1
Gupta, RC; Madhusudanan, KP; Rajanikanth, M	1
Kager, PA	1
Bethell, D; Blakemore, WF; Cavanagh, JB; Day, NP; Dayan, A; Hien, TT; Mai, NT; Medana, I; Phu, NH; Turner, GD; Weller, RO; White, NJ	1
Gupta, RC; Madhusudanan, KP; Rajanikanth, M; Sabarinath, S	1
Gabriëls, M; Plaizier-Vercammen, JA	1
Majori, G	1
Chalearmrult, K; Krudsood, S; Li, Q; Looareesuwan, S; Lugt, CB; Milhous, WK; Vannaphan, S; Wilairatana, P	1
Chan, HW; Gerena, L; Haynes, RK; Ho, WY; Ko, CK; Kyle, DE; Peters, W; Robinson, BL	1
Gupta, RC; Madhusudanan, KP; Sabarinath, S	1
Medhi, B; Pandhi, P; Sukhija, M	2
Garner, P; Omari, A	1
Atemnkeng, MA; De Cock, K; Plaizier-Vercammen, J	1
Chaudhary, S; Puri, SK; Singh, C	1
Efferth, T; Kaina, B	1
Ajayakumar, PV; Bhakuni, RS; Darokar, MP; Gaur, R; Shukla, RS	1

Reviews

8 review(s) available for artemotil and sesquiterpenes

Article	Year
Metabolism of antimalarial sesquiterpene lactones. Pharmacology & therapeutics, 1990, Volume: 48, Issue:3 Topics: Animals; Antimalarials; Artemether; Artemisinins; Humans; Lactones; Sesquiterpenes; Structure-Activity Relationship	1990
Factors relating to neurotoxicity of artemisinin antimalarial drugs "listening to arteether". Medecine tropicale : revue du Corps de sante colonial, 1998, Volume: 58, Issue:3 Suppl Topics: Administration, Oral; Animals; Antimalarials; Artemisinins; Brain Diseases; Brain Stem; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Monitoring; Humans; Practice Guidelines as Topic; Risk Factors; Sesquiterpenes; Solubility; Time Factors	1998
The rational use of qinghaosu and its derivatives: what is the future of new compounds? Medecine tropicale : revue du Corps de sante colonial, 1998, Volume: 58, Issue:3 Suppl Topics: Administration, Oral; Administration, Rectal; Adolescent; Adult; Antimalarials; Artemisinins; Artesunate; Drug and Narcotic Control; Drug Resistance; Female; Humans; Malaria, Falciparum; Male; Middle Aged; Registries; Sesquiterpenes; Suppositories; Thailand	1998
Artemotil Artecef. Current opinion in investigational drugs (London, England : 2000), 2002, Volume: 3, Issue:4 Topics: Animals; Antimalarials; Artemisinins; Clinical Trials as Topic; Humans; Malaria, Falciparum; Sesquiterpenes; Structure-Activity Relationship	2002
[Three newly registered drugs in the Netherlands for the treatment and chemoprophylaxis of malaria: atovaquone-proguanil, artemether-lumefantrine and artemotil]. Nederlands tijdschrift voor geneeskunde, 2003, Feb-15, Volume: 147, Issue:7 Topics: Antimalarials; Artemether; Artemisinins; Atovaquone; Drug Approval; Drug Combinations; Drug Resistance; Ethanolamines; Fluorenes; Humans; Lumefantrine; Malaria; Naphthoquinones; Netherlands; Proguanil; Sesquiterpenes; Treatment Outcome	2003
[Combined antimalarial therapy using artemisinin]. Parassitologia, 2004, Volume: 46, Issue:1-2 Topics: Amodiaquine; Animals; Antimalarials; Artemether; Artemisinins; Artesunate; Chloroquine; Doxycycline; Drug Resistance; Drug Therapy, Combination; Humans; Malaria; Mefloquine; Plasmodium; Pyrimethamine; Quinine; Sesquiterpenes; Sulfadoxine	2004
Malaria: severe, life threatening. Clinical evidence, 2006, Issue:15 Topics: Acute Disease; Antimalarials; Artemether; Artemisinins; Artesunate; Humans; Malaria; Quinine; Sesquiterpenes	2006
Toxicity of the antimalarial artemisinin and its dervatives. Critical reviews in toxicology, 2010, Volume: 40, Issue:5 Topics: Animals; Antimalarials; Artemether; Artemisinins; Artesunate; Clinical Trials as Topic; Developing Countries; Dogs; Drug Administration Routes; Drug-Related Side Effects and Adverse Reactions; Humans; Malaria; Rabbits; Rats; Sesquiterpenes	2010

Trials

10 trial(s) available for artemotil and sesquiterpenes

Article	Year
Effect of arteether alpha/beta on uncomplicated falciparum malaria cases in Upper Assam. The Indian journal of medical research, 1996, Volume: 104 Topics: Adolescent; Adult; Antimalarials; Artemisinins; Female; Humans; India; Malaria, Falciparum; Male; Middle Aged; Sesquiterpenes	1996
Efficacy of alpha,beta-arteether in acute uncomplicated P. falciparum malaria. International journal of clinical pharmacology research, 1997, Volume: 17, Issue:1 Topics: Adolescent; Adult; Animals; Antimalarials; Artemisinins; Female; Humans; Immunoenzyme Techniques; Immunoglobulin G; Malaria, Falciparum; Male; Middle Aged; Plasmodium falciparum; Sesquiterpenes	1997
Effectiveness of alpha-beta arteether in clearing Plasmodium falciparum parasitemia in central India (Madhya Pradesh). The Southeast Asian journal of tropical medicine and public health, 1998, Volume: 29, Issue:2 Topics: Adolescent; Adult; Animals; Antimalarials; Artemisinins; Female; Humans; India; Malaria, Falciparum; Male; Middle Aged; Parasitemia; Plasmodium falciparum; Sesquiterpenes	1998
A randomized controlled trial of artemotil (beta-arteether) in Zambian children with cerebral malaria. The American journal of tropical medicine and hygiene, 2000, Volume: 62, Issue:4 Topics: Antimalarials; Artemisinins; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Injections, Intramuscular; Malaria, Cerebral; Male; Prospective Studies; Quinine; Sesquiterpenes; Survival Rate; Zambia	2000
A multicentric study with arteether in patients of uncomplicated falciparum malaria. The Journal of the Association of Physicians of India, 2001, Volume: 49 Topics: Adolescent; Adult; Aged; Antimalarials; Artemisinins; Female; Humans; Malaria, Falciparum; Male; Middle Aged; Sesquiterpenes	2001
Dose-finding and efficacy study for i.m. artemotil (beta-arteether) and comparison with i.m. artemether in acute uncomplicated P. falciparum malaria. British journal of clinical pharmacology, 2002, Volume: 53, Issue:5 Topics: Acute Disease; Adolescent; Adult; Animals; Antimalarials; Artemether; Artemisinins; Dose-Response Relationship, Drug; Female; Humans; Injections, Intramuscular; Malaria, Falciparum; Male; Middle Aged; Sesquiterpenes	2002
Multicentric clinical trials for safety and efficacy evaluation of alpha;beta arteether in complicated P. falciparum malaria. The Journal of the Association of Physicians of India, 2001, Volume: 49 Topics: Adolescent; Adult; Animals; Antimalarials; Artemisinins; Female; Humans; Malaria, Falciparum; Male; Middle Aged; Plasmodium falciparum; Prospective Studies; Sesquiterpenes	2001
Efficacy of alpha, beta - Arteether in children with cerebral malaria in forested tribal belt. Indian pediatrics, 2002, Volume: 39, Issue:6 Topics: Antimalarials; Artemisinins; Child; Child, Preschool; Ethnicity; Female; Follow-Up Studies; Humans; India; Malaria, Cerebral; Malaria, Falciparum; Male; Rural Population; Sesquiterpenes; Survival Rate; Treatment Outcome	2002
Post-marketing surveillance of arteether in malaria. The Journal of the Association of Physicians of India, 2002, Volume: 50 Topics: Adolescent; Adult; Aged; Antimalarials; Artemisinins; Child; Child, Preschool; Humans; Infant; Malaria, Falciparum; Malaria, Vivax; Middle Aged; Product Surveillance, Postmarketing; Sesquiterpenes	2002
Pharmacokinetic investigation on the therapeutic potential of artemotil (beta-arteether) in Thai patients with severe Plasmodium falciparum malaria. The American journal of tropical medicine and hygiene, 2004, Volume: 71, Issue:6 Topics: Adult; Antimalarials; Area Under Curve; Artemisinins; Half-Life; Humans; Injections, Intramuscular; Malaria, Falciparum; Sesquiterpenes	2004

Other Studies

72 other study(ies) available for artemotil and sesquiterpenes

Article	Year
Hepatic metabolism of artemisinin drugs--III. Induction of hydrogen peroxide production in rat liver microsomes by artemisinin drugs. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1992, Volume: 101, Issue:2 Topics: Animals; Antimalarials; Artemisinins; Hydrogen Peroxide; Kinetics; Male; Microsomes, Liver; NADP; Rats; Rats, Inbred Strains; Sesquiterpenes	1992
Interaction of arteether with the red blood cell in-vitro and its possible importance in the interpretation of plasma concentrations in-vivo. The Journal of pharmacy and pharmacology, 1992, Volume: 44, Issue:3 Topics: Artemisinins; Erythrocyte Membrane; Erythrocytes; Humans; In Vitro Techniques; Sesquiterpenes	1992
The binding of the antimalarial arteether to human plasma proteins in-vitro. The Journal of pharmacy and pharmacology, 1992, Volume: 44, Issue:11 Topics: Adult; Antimalarials; Artemisinins; Blood Proteins; Humans; Male; Middle Aged; Orosomucoid; Protein Binding; Serum Albumin; Sesquiterpenes	1992
[Effect of arteether on Schistosoma japonicum]. Yao xue xue bao = Acta pharmaceutica Sinica, 1992, Volume: 27, Issue:3 Topics: Animals; Artemether; Artemisinins; Female; Histocytochemistry; Mice; Schistosoma japonicum; Schistosomiasis japonica; Schistosomicides; Sesquiterpenes; Therapeutic Equivalency	1992
Plasmodium vinckei petteri: identification of the stages sensitive to arteether. Experimental parasitology, 1992, Volume: 75, Issue:4 Topics: Animals; Antimalarials; Artemisinins; Diglycerides; Ethanol; Malaria; Mice; Plasmodium; Sesquiterpenes; Solvents	1992
Hepatic metabolism of artemisinin drugs--I. Drug metabolism in rat liver microsomes. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1991, Volume: 99, Issue:3 Topics: Animals; Antimalarials; Artemisinins; Chromatography, High Pressure Liquid; Chromatography, Liquid; Kinetics; Liver; Male; Mass Spectrometry; Microsomes, Liver; Rats; Rats, Inbred Strains; Sesquiterpenes	1991
Hepatic metabolism of artemisinin drugs--II. Metabolism of arteether in rat liver cytosol. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1991, Volume: 99, Issue:3 Topics: Animals; Antimalarials; Artemisinins; Chromatography, Liquid; Cytosol; Kinetics; Liver; Male; Mass Spectrometry; Rats; Rats, Inbred Strains; Sesquiterpenes	1991
Identification of the in vivo metabolites of the antimalarial arteether by thermospray high-performance liquid chromatography/mass spectrometry. Biological mass spectrometry, 1991, Volume: 20, Issue:10 Topics: Animals; Antimalarials; Artemisinins; Chromatography, High Pressure Liquid; Male; Mass Spectrometry; Rats; Rats, Inbred Strains; Sesquiterpenes	1991
[Comparative studies on histological and histochemical alterations of Schistosoma japonicum induced by arteether and artemether]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1991, Volume: 12, Issue:5 Topics: Alkaline Phosphatase; Animals; Artemether; Artemisinins; Female; Glycogen; Histocytochemistry; Liver; Male; Mice; Schistosoma japonicum; Schistosomiasis japonica; Schistosomicides; Sesquiterpenes	1991
Determination of the antimalarial arteether and its deethylated metabolite dihydroartemisinin in plasma by high-performance liquid chromatography with reductive electrochemical detection. Journal of pharmaceutical sciences, 1991, Volume: 80, Issue:2 Topics: Animals; Antimalarials; Artemisinins; Biological Availability; Chromatography, High Pressure Liquid; Dogs; Electrochemistry; Oxidation-Reduction; Reproducibility of Results; Sesquiterpenes	1991
Comparison of antimalarial efficacy of alpha, beta, and alpha/beta arteether against Plasmodium cynomolgi B infection in monkeys. The American journal of tropical medicine and hygiene, 1991, Volume: 44, Issue:5 Topics: Animals; Antimalarials; Artemisinins; Female; Malaria; Male; Sesquiterpenes	1991
Effects of artemisinin, dihydroartemisinin and arteether on immune responses of normal mice. International journal of immunopharmacology, 1990, Volume: 12, Issue:4 Topics: Animals; Antibody Formation; Antimalarials; Artemisinins; Carrageenan; Hemolytic Plaque Technique; Hypersensitivity, Delayed; Immunosuppressive Agents; Inflammation; Male; Mice; Sesquiterpenes	1990
Structure elucidation and thermospray high-performance liquid chromatography/mass spectroscopy (HPLC/MS) of the microbial and mammalian metabolites of the antimalarial arteether. Pharmaceutical research, 1990, Volume: 7, Issue:9 Topics: Animals; Antimalarials; Artemisinins; Chromatography, High Pressure Liquid; Fermentation; Mass Spectrometry; Microsomes, Liver; Mucorales; Rats; Sesquiterpenes; Streptomyces	1990
Gametocytocidal activity of the antimalarial alpha/beta arteether against Plasmodium cynomolgi B. The American journal of tropical medicine and hygiene, 1990, Volume: 43, Issue:6 Topics: Animals; Anopheles; Antimalarials; Artemisinins; Macaca mulatta; Parasite Egg Count; Plasmodium; Sesquiterpenes; Spores; Zygote	1990
Microbial metabolism studies of the antimalarial drug arteether. Pharmaceutical research, 1990, Volume: 7, Issue:2 Topics: Antimalarials; Artemisinins; Aspergillus niger; Bacteria; Biotransformation; Chromatography, Thin Layer; Culture Media; Fungi; Magnetic Resonance Spectroscopy; Sesquiterpenes; Spectrophotometry, Ultraviolet	1990
Structure of an ether dimer of deoxydihydroqinghaosu, a potential metabolite of the antimalarial arteether. Acta crystallographica. Section C, Crystal structure communications, 1989, Feb-15, Volume: 45 ( Pt 2) Topics: Antimalarials; Artemisinins; Chemical Phenomena; Chemistry, Physical; Crystallization; Crystallography; Ethers; Molecular Structure; Sesquiterpenes; Software; Triterpenes	1989
Pharmacology of alpha/beta arteether--a potential antimalarial drug. Journal of ethnopharmacology, 1989, Volume: 27, Issue:3 Topics: Animals; Antimalarials; Artemisinins; Behavior, Animal; Blood Pressure; Cats; Diuresis; Female; Heart Rate; Lethal Dose 50; Male; Mice; Passive Cutaneous Anaphylaxis; Rats; Sesquiterpenes	1989
Thermospray mass spectroscopy/high performance liquid chromatographic identification of the metabolites formed from arteether using a rat liver microsome preparation. Biomedical & environmental mass spectrometry, 1989, Volume: 18, Issue:5 Topics: Animals; Antimalarials; Artemisinins; Biotransformation; Chromatography, High Pressure Liquid; In Vitro Techniques; Male; Mass Spectrometry; Microsomes, Liver; Rats; Rats, Inbred Strains; Sesquiterpenes	1989
Determination of arteether in blood plasma by high-performance liquid chromatography with ultraviolet detection after hydrolysis acid. Journal of chromatography, 1989, Aug-25, Volume: 493, Issue:1 Topics: Animals; Antimalarials; Artemisinins; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Hydrochloric Acid; Hydrolysis; Indicators and Reagents; Male; Rats; Rats, Inbred Strains; Sesquiterpenes; Spectrophotometry, Ultraviolet	1989
Micellar solubilization of a new antimalarial drug, beta-arteether. Journal of pharmaceutical sciences, 1989, Volume: 78, Issue:7 Topics: Antimalarials; Artemisinins; Chemical Phenomena; Chemistry, Physical; Micelles; Sesquiterpenes; Sodium Dodecyl Sulfate; Solubility; Surface-Active Agents	1989
Arteether, a qinghaosu derivative, in toxoplasmosis. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1988, Volume: 82, Issue:6 Topics: Animals; Artemisinins; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred Strains; Sesquiterpenes; Toxoplasma; Toxoplasmosis	1988
Arteether, a new antimalarial drug: synthesis and antimalarial properties. Journal of medicinal chemistry, 1988, Volume: 31, Issue:3 Topics: Animals; Antimalarials; Artemisinins; Magnetic Resonance Spectroscopy; Malaria; Mice; Models, Molecular; Plasmodium berghei; Plasmodium falciparum; Sesquiterpenes	1988
Arteether neurotoxicity in the absence of deficits in behavioural performance in rats. Annals of tropical medicine and parasitology, 1995, Volume: 89, Issue:4 Topics: Animals; Antimalarials; Artemisinins; Behavior, Animal; Brain; Conditioning, Operant; Male; Neurons; Rats; Rats, Sprague-Dawley; Sesquiterpenes	1995
Synthesis, characterization, and antimalarial activity of the glucuronides of the hydroxylated metabolites of arteether. Journal of medicinal chemistry, 1995, May-26, Volume: 38, Issue:11 Topics: Animals; Antimalarials; Artemisinins; Chromatography, High Pressure Liquid; Glucuronates; Hydrolysis; Hydroxylation; Microbial Sensitivity Tests; Models, Chemical; Plasmodium falciparum; Sesquiterpenes; Stereoisomerism	1995
Fatal neurotoxicity of arteether and artemether. The American journal of tropical medicine and hygiene, 1994, Volume: 51, Issue:3 Topics: Animals; Antimalarials; Artemether; Artemisinins; Brain; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Injections, Intramuscular; Male; Nervous System Diseases; Random Allocation; Rats; Rats, Sprague-Dawley; Reflex; Reproducibility of Results; Sesquiterpenes; Single-Blind Method; Spinal Cord	1994
Reaction of antimalarial endoperoxides with specific parasite proteins. Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:8 Topics: Animals; Antimalarials; Artemisinins; Autoradiography; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Erythrocytes; Plasmodium falciparum; Protozoan Proteins; Sesquiterpenes; Styrenes	1994
Neurotoxicity in animals due to arteether and artemether. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1994, Volume: 88 Suppl 1 Topics: Animals; Antimalarials; Antiprotozoal Agents; Artemether; Artemisinins; Brain Diseases; Central Nervous System Diseases; Dogs; Dose-Response Relationship, Drug; Gait; Heart Arrest; Rabbits; Rats; Respiratory Insufficiency; Sesquiterpenes	1994
Role of arteether in the treatment of malaria and plans for further development. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1994, Volume: 88 Suppl 1 Topics: Antimalarials; Antiprotozoal Agents; Artemisinins; Chemistry, Pharmaceutical; Drug Evaluation; Drug Resistance; Humans; Malaria, Falciparum; Sesquiterpenes	1994
Arteether administration in humans: preliminary studies of pharmacokinetics, safety and tolerance. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1994, Volume: 88 Suppl 1 Topics: Adolescent; Adult; Antimalarials; Antiprotozoal Agents; Artemisinins; Drug Tolerance; Humans; Injections, Intramuscular; Male; Sesquiterpenes	1994
New, antimalarial, tricyclic 1,2,4-trioxanes: evaluations in mice and monkeys. The American journal of tropical medicine and hygiene, 1994, Volume: 50, Issue:4 Topics: Animals; Antimalarials; Aotus trivirgatus; Artemisinins; Bridged-Ring Compounds; Heterocyclic Compounds; Malaria; Malaria, Falciparum; Mice; Molecular Structure; Plasmodium berghei; Sesquiterpenes	1994
Decomposition of arteether in simulated stomach acid yielding compounds retaining antimalarial activity. Pharmaceutical research, 1993, Volume: 10, Issue:5 Topics: Animals; Antimalarials; Artemisinins; Chromatography, High Pressure Liquid; Gastric Acid; Half-Life; Magnetic Resonance Spectroscopy; Plasmodium falciparum; Sesquiterpenes	1993
Inhibition of Plasmodium falciparum phospholipase A2 by chloroquine, quinine, and arteether. The Journal of parasitology, 1993, Volume: 79, Issue:4 Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Erythrocytes; Humans; Hydrogen-Ion Concentration; Phospholipases A; Phospholipases A1; Phospholipases A2; Plasmodium falciparum; Quinine; Sesquiterpenes	1993
In vitro activity of artemisinin derivatives against African isolates and clones of Plasmodium falciparum. The American journal of tropical medicine and hygiene, 1993, Volume: 49, Issue:3 Topics: Animals; Antimalarials; Artemether; Artemisinins; Chloroquine; Drug Resistance; Mefloquine; Phenanthrenes; Plasmodium falciparum; Quinine; Sesquiterpenes	1993
Comparison of beta-artemether and beta-arteether against malaria parasites in vitro and in vivo. The American journal of tropical medicine and hygiene, 1993, Volume: 48, Issue:3 Topics: Animals; Antimalarials; Aotus trivirgatus; Artemether; Artemisinins; Chloroquine; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Malaria; Malaria, Falciparum; Male; Mefloquine; Mice; Plasmodium berghei; Plasmodium falciparum; Sesquiterpenes; Structure-Activity Relationship	1993
In vivo study of artemisinin and its derivatives against primary amebic meningoencephalitis caused by Naegleria fowleri. The Journal of parasitology, 1995, Volume: 81, Issue:6 Topics: Amebiasis; Amebicides; Amphotericin B; Animals; Artemisinins; Artesunate; Dose-Response Relationship, Drug; Meningoencephalitis; Mice; Naegleria fowleri; Sesquiterpenes	1995
Gametocytocidal activity of alpha/beta arteether by the oral route of administration. The American journal of tropical medicine and hygiene, 1996, Volume: 54, Issue:6 Topics: Administration, Oral; Animals; Anopheles; Antimalarials; Artemisinins; Disease Models, Animal; Macaca mulatta; Malaria; Plasmodium cynomolgi; Sesquiterpenes	1996
Artemisinin neurotoxicity: neuropathology in rats and mechanistic studies in vitro. The American journal of tropical medicine and hygiene, 1997, Volume: 56, Issue:1 Topics: Alkylation; Animals; Antimalarials; Artemisinins; Blood Proteins; Brain; Detergents; Erythrocytes; Male; Mice; Molecular Weight; Nerve Tissue Proteins; Neuroblastoma; Neurons; Octoxynol; Plasmodium falciparum; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Tumor Cells, Cultured	1997
The chemotherapy of rodent malaria. LIII. 'Fenozan B07' (Fenozan-50F), a difluorinated 3,3'-spirocyclopentane 1,2,4-trioxane: comparison with some compounds of the artemisinin series. Annals of tropical medicine and parasitology, 1997, Volume: 91, Issue:1 Topics: Animals; Antimalarials; Artemisinins; Artesunate; Drug Synergism; Malaria; Male; Mice; Parasitemia; Peroxides; Plasmodium; Plasmodium berghei; Plasmodium yoelii; Sesquiterpenes; Spiro Compounds	1997
Arteether: risks of two-week administration in Macaca mulatta. The American journal of tropical medicine and hygiene, 1997, Volume: 56, Issue:4 Topics: Animals; Antimalarials; Artemisinins; Central Nervous System; Cranial Nerves; Disease Models, Animal; Macaca mulatta; Male; Neurons; Olivary Nucleus; Reticular Formation; Sesquiterpenes; Vestibular Nuclei	1997
Identification of the glucuronides of the hydroxylated metabolites of the antimalarial arteether in rat plasma and urine by thermospray high-performance liquid chromatography/mass spectrometry. Journal of pharmaceutical sciences, 1997, Volume: 86, Issue:8 Topics: Animals; Antimalarials; Artemisinins; Chromatography, High Pressure Liquid; Glucuronates; Male; Mass Spectrometry; Rats; Rats, Wistar; Sesquiterpenes	1997
Plasmodium fragile: efficacy of arteether (alpha/beta) against cerebral malaria model. Experimental parasitology, 1997, Volume: 87, Issue:3 Topics: Animals; Antimalarials; Artemisinins; Disease Models, Animal; Female; Macaca mulatta; Malaria, Cerebral; Male; Parasitemia; Plasmodium; Sesquiterpenes	1997
Effects of Plasmodium berghei infection on arteether metabolism and disposition. Pharmacology, 1997, Volume: 54, Issue:5 Topics: Animals; Antimalarials; Area Under Curve; Artemisinins; Bile; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Half-Life; Isotope Labeling; Liver; Malaria; Male; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Perfusion; Plasmodium berghei; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Tissue Distribution	1997
Failure to detect significant in-vitro activity of artemether and beta-arteether against bacteria and fungi by an agar dilution test. The Journal of antimicrobial chemotherapy, 1997, Volume: 40, Issue:5 Topics: Antifungal Agents; Artemether; Artemisinins; Bacteria; Fungi; Microbial Sensitivity Tests; Sesquiterpenes	1997
Dose-dependent brainstem neuropathology following repeated arteether administration in rats. Brain research bulletin, 1998, Volume: 45, Issue:2 Topics: Animals; Antimalarials; Artemisinins; Behavior, Animal; Brain Diseases; Brain Stem; Dose-Response Relationship, Drug; Male; Neurons; Rats; Rats, Sprague-Dawley; Sesquiterpenes	1998
The pharmacokinetics and bioavailability of dihydroartemisinin, arteether, artemether, artesunic acid and artelinic acid in rats. The Journal of pharmacy and pharmacology, 1998, Volume: 50, Issue:2 Topics: Absorption; Animals; Antimalarials; Area Under Curve; Artemether; Artemisinins; Biological Availability; Bridged Bicyclo Compounds, Heterocyclic; Male; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Succinates	1998
Metabolism of beta-arteether to dihydroqinghaosu by human liver microsomes and recombinant cytochrome P450. Drug metabolism and disposition: the biological fate of chemicals, 1998, Volume: 26, Issue:4 Topics: Antimalarials; Artemisinins; Cytochrome P-450 Enzyme System; Humans; Microsomes, Liver; Sesquiterpenes	1998
In vitro sensitivity of Plasmodium falciparum to eight antimalarials in China-Myanmar and China-Lao PDR border areas. The Southeast Asian journal of tropical medicine and public health, 1997, Volume: 28, Issue:3 Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Artesunate; China; Chloroquine; Drug Evaluation, Preclinical; Drug Resistance; Humans; Laos; Microbial Sensitivity Tests; Myanmar; Naphthyridines; Plasmodium falciparum; Quinine; Sesquiterpenes	1997
Behavioral and neural toxicity of arteether in rats. Pharmacology, biochemistry, and behavior, 1998, Volume: 60, Issue:2 Topics: Acoustic Stimulation; Animals; Antimalarials; Artemisinins; Behavior, Animal; Brain Stem; Discrimination Learning; Discrimination, Psychological; Male; Nervous System Diseases; Rats; Rats, Sprague-Dawley; Sesquiterpenes	1998
Effect of alpha,beta-arteether against primary amoebic meningoencephalitis in Swiss mice. Indian journal of experimental biology, 1998, Volume: 36, Issue:8 Topics: Amebiasis; Amebicides; Amphotericin B; Animals; Artemisinins; Meningoencephalitis; Mice; Naegleria fowleri; Sesquiterpenes	1998
In vitro neurotoxicity of artemisinin derivatives. Medecine tropicale : revue du Corps de sante colonial, 1998, Volume: 58, Issue:3 Suppl Topics: Animals; Antimalarials; Artemether; Artemisinins; Cell Differentiation; Central Nervous System Diseases; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Mice; Microscopy, Electron; Neuroblastoma; Neurons; Reproducibility of Results; Sesquiterpenes; Tumor Cells, Cultured	1998
Studies on hepatic oxidative stress and antioxidant defence systems during arteether treatment of Plasmodium yoelii nigeriensis infected mice. Molecular and cellular biochemistry, 1999, Volume: 196, Issue:1-2 Topics: Animals; Antimalarials; Antioxidants; Artemisinins; Liver; Malaria; Mice; Oxidative Stress; Plasmodium yoelii; Sesquiterpenes; Xanthine Oxidase	1999
Acute high dose arteether toxicity in rats. Neurotoxicology, 1999, Volume: 20, Issue:5 Topics: Acoustic Stimulation; Animals; Antimalarials; Artemisinins; Behavior, Animal; Brain; Coloring Agents; Discrimination, Psychological; Male; Nervous System Diseases; Neurons; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Sesquiterpenes	1999
Arteether-induced brain injury in Macaca mulatta. I. The precerebellar nuclei: the lateral reticular nuclei, paramedian reticular nuclei, and perihypoglossal nuclei. Anatomy and embryology, 2000, Volume: 201, Issue:5 Topics: Animals; Antimalarials; Artemisinins; Brain Injuries; Brain Mapping; Cerebellum; Dose-Response Relationship, Drug; Drug Administration Schedule; Macaca mulatta; Malaria, Cerebral; Male; Medulla Oblongata; Nerve Degeneration; Neural Pathways; Neurons; Reticular Formation; Sesquiterpenes	2000
Behavioral and neural toxicity of the artemisinin antimalarial, arteether, but not artesunate and artelinate, in rats. Pharmacology, biochemistry, and behavior, 2000, Volume: 67, Issue:1 Topics: Animals; Antimalarials; Artemisinins; Artesunate; Behavior, Animal; Brain; Brain Stem; Discrimination Learning; Male; Rats; Rats, Sprague-Dawley; Sesquiterpenes	2000
A simple microbiological assay for the stereospecific differentiation of alpha and beta isomers of arteether. Phytotherapy research : PTR, 2000, Volume: 14, Issue:8 Topics: Antimalarials; Artemisinins; Biological Assay; Chromatography, Thin Layer; DNA Topoisomerases, Type II; Escherichia coli; Mutation; Plasmids; Sesquiterpenes; Stereoisomerism	2000
Newer antimalarials. The Journal of the Association of Physicians of India, 2000, Volume: 48, Issue:7 Topics: Animals; Antimalarials; Artemisinins; Dose-Response Relationship, Drug; Humans; Malaria, Falciparum; Sesquiterpenes	2000
Effect of beta-arteether treatment on erythrocytic methemoglobin reductase system in Plasmodium yoelii nigeriensis infected mice. Drug and chemical toxicology, 2001, Volume: 24, Issue:2 Topics: Animals; Antimalarials; Artemisinins; Cytochrome-B(5) Reductase; Erythrocytes; Malaria; Mice; Parasitemia; Plasmodium yoelii; Sesquiterpenes; Time Factors	2001
Effects of arteether on an auditory radial-arm maze task in rats. Physiology & behavior, 2001, Volume: 73, Issue:1-2 Topics: Animals; Artemisinins; Auditory Pathways; Auditory Perception; Brain Stem; Cochlear Nerve; Injections, Intramuscular; Male; Maze Learning; Mental Recall; Orientation; Rats; Rats, Sprague-Dawley; Sesquiterpenes	2001
Arteether in therapy of malaria. The Journal of the Association of Physicians of India, 2001, Volume: 49 Topics: Antimalarials; Artemisinins; Humans; Malaria, Falciparum; Sesquiterpenes	2001
mRNA expression profiles for the response of human tumor cell lines to the antimalarial drugs artesunate, arteether, and artemether. Biochemical pharmacology, 2002, Aug-15, Volume: 64, Issue:4 Topics: Antimalarials; Artemether; Artemisinins; Artesunate; Cell Line; Gene Expression Profiling; Humans; Oligonucleotide Array Sequence Analysis; RNA, Messenger; Sesquiterpenes; Transcription, Genetic; Tumor Cells, Cultured	2002
Neurotoxicity and efficacy of arteether related to its exposure times and exposure levels in rodents. The American journal of tropical medicine and hygiene, 2002, Volume: 66, Issue:5 Topics: Animals; Anorexia; Antimalarials; Area Under Curve; Artemether; Artemisinins; Biological Availability; Malaria; Male; Mice; Muscle, Skeletal; Neurotoxins; Plasmodium berghei; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Tissue Distribution	2002
Liquid chromatographic-mass spectrometric method for the determination of alpha-,beta-arteether in rat serum. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2003, Jan-15, Volume: 783, Issue:2 Topics: Animals; Antimalarials; Artemisinins; Calibration; Chromatography, Liquid; Rats; Reproducibility of Results; Sensitivity and Specificity; Sesquiterpenes; Spectrometry, Mass, Electrospray Ionization	2003
Neuropathological assessment of artemether-treated severe malaria. Lancet (London, England), 2003, Jul-26, Volume: 362, Issue:9380 Topics: Adult; Antimalarials; Artemether; Artemisinins; Brain Diseases; Brain Stem; Female; Humans; Malaria, Falciparum; Male; Quinine; Sesquiterpenes	2003
A sensitive and selective liquid chromatographic/electrospray ionization tandem mass spectrometric assay for the simultaneous quantification of alpha-,beta-arteether and its metabolite dihydroartemisinin in plasma, useful for pharmacokinetic studies. Journal of mass spectrometry : JMS, 2003, Volume: 38, Issue:7 Topics: Antimalarials; Artemisinins; Chromatography, High Pressure Liquid; Sensitivity and Specificity; Sesquiterpenes; Spectrometry, Mass, Electrospray Ionization	2003
Densitometric thin-layer chromatographic determination of artemisinin and its lipophilic derivatives, artemether and arteether. Journal of chromatographic science, 2003, Volume: 41, Issue:7 Topics: Artemisinins; Chromatography, Thin Layer; Densitometry; Reproducibility of Results; Sensitivity and Specificity; Sesquiterpenes	2003
Convenient access both to highly antimalaria-active 10-arylaminoartemisinins, and to 10-alkyl ethers including artemether, arteether, and artelinate. Chembiochem : a European journal of chemical biology, 2005, Volume: 6, Issue:4 Topics: Animals; Antimalarials; Artemether; Artemisinins; Malaria; Mice; Molecular Structure; Parasitemia; Plasmodium berghei; Plasmodium falciparum; Plasmodium yoelii; Sesquiterpenes	2005
Pharmacokinetics of the diastereomers of arteether, a potent antimalarial drug, in rats. Biopharmaceutics & drug disposition, 2005, Volume: 26, Issue:6 Topics: Administration, Oral; Animals; Antimalarials; Area Under Curve; Artemisinins; Injections, Intramuscular; Injections, Intravenous; Male; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Stereoisomerism	2005
Effects of artemisinin, artemether, arteether on the pharmacokinetics of carbamazepine. Pharmacology, 2006, Volume: 76, Issue:3 Topics: Administration, Oral; Animals; Anticonvulsants; Antimalarials; Area Under Curve; Artemether; Artemisinins; Biological Availability; Carbamazepine; Chromatography, High Pressure Liquid; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Half-Life; Injections, Intramuscular; Lactones; Male; Rabbits; Sesquiterpenes; Suspensions	2006
Effects of artemisinin, artemether, and arteether on the pharmacokinetics of phenytoin. Methods and findings in experimental and clinical pharmacology, 2006, Volume: 28, Issue:2 Topics: Animals; Anticonvulsants; Antimalarials; Area Under Curve; Artemether; Artemisinins; Chromatography, High Pressure Liquid; Cross-Over Studies; Half-Life; Male; Metabolic Clearance Rate; Phenytoin; Rabbits; Sesquiterpenes	2006
Quality control of active ingredients in artemisinin-derivative antimalarials within Kenya and DR Congo. Tropical medicine & international health : TM & IH, 2007, Volume: 12, Issue:1 Topics: Antimalarials; Artemether; Artemisinins; Artesunate; Capsules; Chromatography, High Pressure Liquid; Democratic Republic of the Congo; Dosage Forms; Endemic Diseases; Humans; Kenya; Malaria, Falciparum; Quality Control; Sesquiterpenes; Tablets	2007
Orally active esters of dihydroartemisinin: Synthesis and antimalarial activity against multidrug-resistant Plasmodium yoelii in mice. Bioorganic & medicinal chemistry letters, 2008, Feb-15, Volume: 18, Issue:4 Topics: Adamantane; Administration, Oral; Animals; Antimalarials; Artemisinins; Biphenyl Compounds; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Esters; Malaria; Mice; Models, Molecular; Plasmodium yoelii; Sesquiterpenes; Structure-Activity Relationship	2008
In vitro antimalarial studies of novel artemisinin biotransformed products and its derivatives. Phytochemistry, 2014, Volume: 107 Topics: Antimalarials; Artemisinins; Biotransformation; England; Humans; India; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Rhizopus; Sesquiterpenes	2014