Page last updated: 2024-08-25

artemisinin and heme

artemisinin has been researched along with heme in 62 studies

Research

Studies (62)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	6 (9.68)	18.2507
2000's	27 (43.55)	29.6817
2010's	21 (33.87)	24.3611
2020's	8 (12.90)	2.80

Authors

Authors	Studies
Meshnick, SR	2
Little, B; Meshnick, SR; Yang, YZ	1
Paitayatat, S; Tarnchompoo, B; Thebtaranonth, Y; Yuthavong, Y	1
Adams, PA; Berman, PA	1
Fang, F; Omura, S; Tanaka, Y; Zhang, CH; Zhang, XW	1
Chauhan, VS; Pandey, AV; Singh, RL; Tekwani, BL	1
Kapetanaki, S; Varotsis, C	1
Cazelles, J; Dechy-Cabaret, O; Meunier, B; Robert, A	1
Chauhan, VS; Kannan, R; Sahal, D	1
Coppel, Y; Meunier, B; Robert, A	1
Xiao, SH; Zhai, ZL	1
Basilico, N; Haynes, RK; Monti, D; Olliaro, P; Parapini, S; Taramelli, D	1
Bégué, JP; Bonnet-Delpon, D; Meunier, B; Robert, A; Rodriguez, M	1
Claparols, C; Meunier, B; Robert, A; Selmeczi, K	1
O'Neill, PM; Posner, GH	1
Claeys, M; Kosevich, MV; Pashynska, VA; Van den Heuvel, H	1
Chauhan, VS; Kannan, R; Kukreti, S; Kumar, K; Sahal, D	1
Basilico, N; Mondani, M; Monti, D; Olliaro, P; Parapini, S; Taramelli, D	1
Benoit-Vical, F; Claparols, C; Meunier, B; Robert, A	1
Bilia, AR; Casini, A; Gabbiani, C; Messori, L; Siragusa, M; Vincieri, FF	1
Chae, J; Choi, I; Kim, C	1
Haynes, RK; Krishna, S; Mercereau-Puijalon, O; Staines, HM; Woodrow, CJ	1
Liang, RL; Liu, TW; Qu, LB; Tang, MS; Xiang, BR	1
Accardo, A; Laurent, SA; Mazarguil, H; Meunier, B; Meyer, M; Robert, A	1
Benoit-Vical, F; Lelièvre, J; Loup, C; Meunier, B	1
Charman, SA; Charman, WN; Chiu, FC; Creek, DJ; Dong, Y; Prankerd, RJ; Vennerstrom, JL	1
Araújo, JQ; Carneiro, JW; de Araujo, MT; Leite, FH; Taranto, AG	1
Gerhard, GS; Zhang, S	2
Little, RJ; Parra, Z; Pestano, AA	1
Bumke, MA; ElSohly, MA; Galal, AM; Gul, W; Han, B; Hollingshead, MG; Newton, DL; Slade, D; Stockwin, LH; Yu, SX	1
Naik, PK; Singh, H; Srivastava, M	1
Moles, P; Oliva, M; Safont, VS; Sánchez-González, A	1
Meunier, B; Robert, A	1
Copple, IM; Maggs, JL; Mercer, AE; O'Neill, PM; Park, BK	1
Moles, P; Oliva, M; Safont, VS	1
Kittikool, D; Sibmooh, N; Srihirun, S; Tangnitipong, S; Thaptimthong, T; Udomsangpetch, R; Unchern, S	1
Benoit-Vical, F; Berry, A; Bousejra-Elgarah, F; Iriart, X; Lelièvre, J; Meunier, B; Nicolau-Travers, ML; Njomnang Soh, P; Witkowski, B	1
Figadère, B; Grellier, P; Harfouche, A; Jullian, JC; Maciuk, A; Mouray, E; Muñoz-Durango, K; Quintin, J; Spelman, K; Torijano-Gutiérrez, S	1
Chen, H; Gerhard, GS; Webster, J; Zhang, S	1
Cebrián-Torrejón, G; Doménech-Carbó, A; Figadère, B; Maciuk, A; Poupon, E	1
Fabre, PL; Ibrahim, H; Najahi, E; Nepveu, F; Perio, P; Reybier, K; Souard, F; Yen, NT	1
Benoit-Vical, F; Claparols, C; Robert, A; Witkowski, B	1
Cheu, KW; Coghi, P; Haynes, RK; Monti, D; N'Da, D	1
Brasil, DS; Carvalho, JC; Costa, EV; Hage-Melim, LI; Lima, CS; Lobato, CC; Macêdo, WJ; Santos, CB; Souto, RN; Vieira, JB	1
Gupta, AK; Saxena, AK	1
Chia, WN; He, Y; Hua, ZC; Lee, YM; Lee, YQ; Li, Z; Liew, CX; Lim, CT; Lim, TK; Lin, Q; Liu, B; Liu, M; Loh, CC; Lu, N; Shen, HM; Tan, KS; Wang, J; Yuan, LX; Zhang, CJ; Zhang, J	1
Li, W; Tang, G; Xiao, Y; Zhou, Y	1
Andenmatten, N; Clark, RL; Clode, SA; Edwards, TL; Huber, AC; Kinney, J; Longo, M; Rhodes, J; Rückle, T; Walker, DK; Wells, T	1
Jiang, TL; Li, CH; Tang, T	1
Heller, LE; Roepe, PD	1
Cumming, BM; Goldring, JPD	1
Benoit-Vical, F; Liu, Y; Meunier, B; Robert, A	1
Harding, CR; Kloehn, J; Soldati-Favre, D	1
Boydston, EA; Fidock, DA; Gnädig, NF; Harding, CR; Herneisen, AL; Lourido, S; Markus, BM; Okombo, J; Petrova, B; Sidik, SM; Ward, KE	1
Heller, LE; Julian, E; Ribbiso, KA; Roepe, PD; Taye, A; Willems, AV	1
Aratikatla, EK; Asad, M; Bhattacharya, AK; Datta, G; Kalamuddin, M; Malhotra, P; Mohmmed, A; Rana, KC; Sundararaman, S	1
Zhou, B; Zhu, P	1
Berger, W; Bian, S; Dyczynski, M; Efferth, T; Elling, U; Gabler, L; Gojo, J; Hagelkruys, A; Hoepfner, D; Horn, M; Knoblich, JA; Krauditsch, C; Laemmerer, A; Lötsch, D; Orthofer, M; Penninger, JM; Peyrl, A; Rózsová, M; Spiegl-Kreinecker, S; Studer, C; Taubenschmid-Stowers, J; Widhalm, G	1
Chen, J; Ji, H; Ni, S; Tian, J; Wang, L; Wu, X; Xu, J; Zhang, Y; Zhao, X	1
Cao, J; Fang, C; Li, Y; Liu, C; Shen, Y; Si, W; Sun, J; Xu, W; Yan, X; Yin, M	1

Reviews

9 review(s) available for artemisinin and heme

Article	Year
The mode of action of antimalarial endoperoxides. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1994, Volume: 88 Suppl 1 Topics: Alkylation; Animals; Antimalarials; Antiprotozoal Agents; Artemisinins; Biotransformation; Free Radicals; Heme; Humans; Iron; Peroxides; Plasmodium; Sesquiterpenes	1994
From mechanistic studies on artemisinin derivatives to new modular antimalarial drugs. Accounts of chemical research, 2002, Volume: 35, Issue:3 Topics: Alkylating Agents; Animals; Antimalarials; Artemisinins; Drug Design; Drugs, Chinese Herbal; Heme; Humans; Sesquiterpenes	2002
[The antimalarial mechanism of artemisinin and its derivatives]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 2001, Volume: 19, Issue:3 Topics: Animals; Antimalarials; Artemisinins; Free Radicals; Heme; Plasmodium berghei; Plasmodium falciparum; Sesquiterpenes	2001
A medicinal chemistry perspective on artemisinin and related endoperoxides. Journal of medicinal chemistry, 2004, Jun-03, Volume: 47, Issue:12 Topics: Alkylation; Antimalarials; Artemisinins; Cysteine Proteinase Inhibitors; Drug Resistance; Drug Stability; Drug Therapy, Combination; Heme; Humans; Malaria, Falciparum; Oxidative Stress; Prodrugs; Sesquiterpenes	2004
Heme as trigger and target for trioxane-containing antimalarial drugs. Accounts of chemical research, 2010, Nov-16, Volume: 43, Issue:11 Topics: Antimalarials; Antineoplastic Agents; Artemisinins; Cell Line, Tumor; Cell Proliferation; Heme; Heterocyclic Compounds; Humans; Plasmodium	2010
Considerations on the mechanism of action of artemisinin antimalarials: part 1--the 'carbon radical' and 'heme' hypotheses. Infectious disorders drug targets, 2013, Volume: 13, Issue:4 Topics: Animals; Antimalarials; Artemisinins; Carbon; Heme; Humans; Malaria	2013
[Research progress on heme metabolism in intraerythrocytic plasmodium]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2018, Volume: 43, Issue:18 Topics: Antimalarials; Artemisinins; Atovaquone; Chloroquine; Erythrocytes; Heme; Hemoglobins; Humans; Plasmodium	2018
Small Molecules: The Past or the Future in Drug Innovation? Metal ions in life sciences, 2019, Jan-14, Volume: 19 Topics: Alzheimer Disease; Antimalarials; Artemisinins; Copper; Drug Design; Heme; Humans; Iron; Malaria; Schistosomiasis	2019
Supply and demand-heme synthesis, salvage and utilization by Apicomplexa. The FEBS journal, 2021, Volume: 288, Issue:2 Topics: Animals; Anti-Infective Agents; Artemisinins; Cryptosporidium; Cytochromes; Erythrocytes; Ferrochelatase; Gene Expression; Heme; Host-Pathogen Interactions; Humans; Life Cycle Stages; Metabolic Networks and Pathways; Plasmodium berghei; Plasmodium falciparum; Protozoan Proteins; Toxoplasma	2021

Other Studies

53 other study(ies) available for artemisinin and heme

Article	Year
Alkylation of proteins by artemisinin. Effects of heme, pH, and drug structure. Biochemical pharmacology, 1994, Aug-03, Volume: 48, Issue:3 Topics: Alkylating Agents; Antimalarials; Artemisinins; Blood Proteins; Drugs, Chinese Herbal; Erythrocyte Membrane; Heme; Humans; Hydrogen-Ion Concentration; Serum Albumin; Sesquiterpenes; Structure-Activity Relationship	1994
Correlation of antimalarial activity of artemisinin derivatives with binding affinity with ferroprotoporphyrin IX. Journal of medicinal chemistry, 1997, Feb-28, Volume: 40, Issue:5 Topics: Animals; Antimalarials; Artemisinins; Cells, Cultured; Heme; Magnetic Resonance Spectroscopy; Molecular Structure; Plasmodium falciparum; Sesquiterpenes	1997
Artemisinin enhances heme-catalysed oxidation of lipid membranes. Free radical biology & medicine, 1997, Volume: 22, Issue:7 Topics: Antimalarials; Artemisinins; Artesunate; Benzothiazoles; Erythrocyte Membrane; Free Radical Scavengers; Heme; Humans; Hydrogen Peroxide; Lipid Peroxidation; Malondialdehyde; Membrane Lipids; Oxidation-Reduction; Peroxidases; Sesquiterpenes; Spectrophotometry; Sulfonic Acids; Thiobarbiturates; Vitamin E	1997
Heme-dependent radical generation from antimalarial fungal metabolites, radicicol and heptelidic acid. The Journal of antibiotics, 1998, Volume: 51, Issue:4 Topics: Animals; Antimalarials; Artemisinins; Binding Sites; Free Radicals; Fungi; Heme; Hemin; Lactones; Macrolides; Mitosporic Fungi; Plasmodium falciparum; Sesquiterpenes	1998
Artemisinin, an endoperoxide antimalarial, disrupts the hemoglobin catabolism and heme detoxification systems in malarial parasite. The Journal of biological chemistry, 1999, Jul-02, Volume: 274, Issue:27 Topics: Animals; Antimalarials; Artemisinins; Drugs, Chinese Herbal; Electrophoresis, Polyacrylamide Gel; Heme; Hemeproteins; Hemoglobins; Male; Mice; Plasmodium falciparum; Plasmodium yoelii; Prostaglandin Endoperoxides; Sesquiterpenes	1999
Ferryl-oxo heme intermediate in the antimalarial mode of action of artemisinin. FEBS letters, 2000, Jun-02, Volume: 474, Issue:2-3 Topics: Antimalarials; Artemisinins; Dimerization; Heme; Hemin; Heterocyclic Compounds, 3-Ring; Iron; Kinetics; Oxidation-Reduction; Oxygen; Oxygen Isotopes; Sesquiterpenes; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Vibration	2000
Heme-artemisinin adducts are crucial mediators of the ability of artemisinin to inhibit heme polymerization. Chemistry & biology, 2002, Volume: 9, Issue:3 Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Heme; Plasmodium yoelii; Polymers; Protein Binding; Proteins; Sesquiterpenes	2002
Alkylation of heme by the antimalarial drug artemisinin. Chemical communications (Cambridge, England), 2002, Mar-07, Issue:5 Topics: Alkylation; Antimalarials; Artemisinins; Glutathione; Heme; Oxidation-Reduction; Protoporphyrins; Sesquiterpenes	2002
Artemisinin antimalarials do not inhibit hemozoin formation. Antimicrobial agents and chemotherapy, 2003, Volume: 47, Issue:3 Topics: Antimalarials; Artemisinins; Heme; Hemeproteins; Hemin; Sesquiterpenes	2003
Alkylation of manganese(II) tetraphenylporphyrin by antimalarial fluorinated artemisinin derivatives. Bioorganic & medicinal chemistry letters, 2003, Mar-24, Volume: 13, Issue:6 Topics: Alkylation; Antimalarials; Artemisinins; Heme; Magnetic Resonance Spectroscopy; Mass Spectrometry; Metalloporphyrins; Models, Molecular; Molecular Conformation; Peroxides; Sesquiterpenes; Spectrophotometry, Ultraviolet	2003
Artemisinin and heme. Antimicrobial agents and chemotherapy, 2003, Volume: 47, Issue:8 Topics: Animals; Artemisinins; Biotransformation; Heme; Hemeproteins; Humans; Protein Binding; Sesquiterpenes	2003
Alkylation of human hemoglobin A0 by the antimalarial drug artemisinin. FEBS letters, 2004, Jan-02, Volume: 556, Issue:1-3 Topics: Alkylation; Antimalarials; Artemisinins; Chromatography, High Pressure Liquid; Heme; Hemoglobin A; Humans; Oxidation-Reduction; Oxyhemoglobins; Sesquiterpenes; Spectrometry, Mass, Electrospray Ionization	2004
Characterization of noncovalent complexes of antimalarial agents of the artemisinin-type and FE(III)-heme by electrospray mass spectrometry and collisional activation tandem mass spectrometry. Journal of the American Society for Mass Spectrometry, 2004, Volume: 15, Issue:8 Topics: Antimalarials; Artemisinins; Cyclotrons; Heme; Sesquiterpenes; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared	2004
Reaction of artemisinin with haemoglobin: implications for antimalarial activity. The Biochemical journal, 2005, Jan-15, Volume: 385, Issue:Pt 2 Topics: Alkylation; Animals; Antimalarials; Artemisinins; Binding, Competitive; Heme; Hemeproteins; Hemoglobins; Myoglobin; Oxidation-Reduction; Plasmodium falciparum; Proteins; Protozoan Proteins; Sesquiterpenes; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization	2005
Evidence that haem iron in the malaria parasite is not needed for the antimalarial effects of artemisinin. FEBS letters, 2004, Sep-24, Volume: 575, Issue:1-3 Topics: Animals; Antimalarials; Artemisinins; Carbon Monoxide; Chloroquine; Erythrocytes; Heme; Hemoglobins; Humans; Iron; Malaria; Oxidation-Reduction; Oxidative Stress; Oxygen; Plasmodium falciparum; Sesquiterpenes	2004
The antimalarial drug artemisinin alkylates heme in infected mice. Proceedings of the National Academy of Sciences of the United States of America, 2005, Sep-20, Volume: 102, Issue:38 Topics: Alkylation; Animals; Antimalarials; Artemisinins; Female; Heme; Malaria; Mice; Plasmodium; Sesquiterpenes; Spleen; Urine	2005
The reaction of artemisinins with hemoglobin: a unified picture. Bioorganic & medicinal chemistry, 2006, May-01, Volume: 14, Issue:9 Topics: Acetates; Acetonitriles; Artemisinins; Buffers; Hemoglobins; Humans; Hydrogen-Ion Concentration; Iron; Molecular Structure; Protoporphyrins; Sesquiterpenes; Spectrum Analysis	2006
Homology modeling and molecular docking study of translationally controlled tumor protein and artemisinin. Archives of pharmacal research, 2006, Volume: 29, Issue:1 Topics: Antimalarials; Artemisinins; Base Sequence; Biomarkers, Tumor; Computer Simulation; Heme; Humans; Models, Molecular; Molecular Sequence Data; Protein Conformation; Sesquiterpenes; Software; Tumor Protein, Translationally-Controlled 1	2006
Re-evaluation of how artemisinins work in light of emerging evidence of in vitro resistance. Trends in molecular medicine, 2006, Volume: 12, Issue:5 Topics: Antimalarials; Artemisinins; Drug Resistance; Genes, Protozoan; Heme; Humans; Protozoan Proteins; Sesquiterpenes	2006
[A quantum chemistry investigation on antimalarial mechanism of Qinghaosu based on cleavage of the peroxide bridge]. Yao xue xue bao = Acta pharmaceutica Sinica, 2006, Volume: 41, Issue:6 Topics: Antimalarials; Artemisia; Artemisinins; Electron Transport; Free Radicals; Heme; Models, Chemical; Peroxides; Plants, Medicinal; Quantum Theory	2006
Interaction of iron(II)-heme and artemisinin with a peptide mimic of Plasmodium falciparum HRP-II. Journal of inorganic biochemistry, 2007, Volume: 101, Issue:11-12 Topics: Animals; Artemisinins; Heme; Iron; Kinetics; Models, Chemical; Molecular Mimicry; Molecular Structure; Peptides; Plasmodium falciparum; Protein Binding; Proteins; Protozoan Proteins	2007
Trioxaquines and heme-artemisinin adducts inhibit the in vitro formation of hemozoin better than chloroquine. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:10 Topics: Alkylation; Animals; Antimalarials; Artemisinins; Chloroquine; Dioxanes; Heme; Hemeproteins; Plasmodium; Sesquiterpenes; Spectrophotometry, Infrared	2007
Relationship between antimalarial activity and heme alkylation for spiro- and dispiro-1,2,4-trioxolane antimalarials. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:4 Topics: Alkylation; Animals; Antimalarials; Artemisinins; Heme; Humans; Kinetics; Parasitic Sensitivity Tests; Plasmodium falciparum; Spiro Compounds; Structure-Activity Relationship	2008
Interaction between artemisinin and heme. A Density Functional Theory study of structures and interaction energies. Bioorganic & medicinal chemistry, 2008, May-01, Volume: 16, Issue:9 Topics: Artemisinins; Computer Simulation; Electron Transport; Heme; Humans; Models, Chemical; Molecular Conformation; Quantum Theory	2008
Heme activates artemisinin more efficiently than hemin, inorganic iron, or hemoglobin. Bioorganic & medicinal chemistry, 2008, Aug-15, Volume: 16, Issue:16 Topics: Antimalarials; Artemisinins; Ferrous Compounds; Heme; Hemin; Hemoglobins; Spectrophotometry, Ultraviolet	2008
Modeling of peroxide activation in artemisinin derivatives by serial docking. Journal of molecular modeling, 2009, Volume: 15, Issue:7 Topics: Anti-Infective Agents; Artemisinins; Binding Sites; Binding, Competitive; Computer Simulation; Heme; Ligands; Models, Molecular; Molecular Structure; Peroxides; Quantitative Structure-Activity Relationship	2009
Artemisinin dimer anticancer activity correlates with heme-catalyzed reactive oxygen species generation and endoplasmic reticulum stress induction. International journal of cancer, 2009, Sep-15, Volume: 125, Issue:6 Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; Artemisia; Artemisinins; Biomarkers; Blotting, Western; Calcium; Cell Cycle; Dimerization; Endoplasmic Reticulum; Enzyme Inhibitors; Gene Expression Profiling; Heme; Heme Oxygenase-1; Humans; Lysine; Oligonucleotide Array Sequence Analysis; Oxidative Stress; Reactive Oxygen Species; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Thapsigargin	2009
Application of the linear interaction energy method for rational design of artemisinin analogues as haeme polymerisation inhibitors. SAR and QSAR in environmental research, 2009, Volume: 20, Issue:3-4 Topics: Antimalarials; Artemisinins; Drug Design; Heme; Humans; Models, Statistical; Monte Carlo Method	2009
Heme mediates cytotoxicity from artemisinin and serves as a general anti-proliferation target. PloS one, 2009, Oct-28, Volume: 4, Issue:10 Topics: Aminolevulinic Acid; Anti-Infective Agents; Antineoplastic Agents; Artemisinins; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Evaluation, Preclinical; Heme; Humans; Iron; Models, Chemical; Protoporphyrins; Spectrophotometry; Transferrin	2009
A topological study of the decomposition of 6,7,8-trioxabicyclo[3.2.2]nonane induced by Fe(II): modeling the artemisinin reaction with heme. The journal of physical chemistry. B, 2010, Jan-21, Volume: 114, Issue:2 Topics: Alkanes; Antimalarials; Artemisinins; Ferrous Compounds; Heme; Models, Chemical; Models, Molecular; Oxygen	2010
The role of heme and the mitochondrion in the chemical and molecular mechanisms of mammalian cell death induced by the artemisinin antimalarials. The Journal of biological chemistry, 2011, Jan-14, Volume: 286, Issue:2 Topics: Antimalarials; Apoptosis; Artemisinins; Artesunate; HeLa Cells; Heme; Humans; Iron; Mitochondria; Peroxides; Reactive Oxygen Species	2011
Topological study of the late steps of the artemisinin decomposition process: modeling the outcome of the experimentally obtained products. The journal of physical chemistry. B, 2011, Jan-20, Volume: 115, Issue:2 Topics: Alkanes; Artemisinins; Bridged Bicyclo Compounds, Heterocyclic; Computer Simulation; Electrons; Ferrous Compounds; Heme; Hemeproteins; Hemoglobins; Models, Chemical; Models, Molecular; Models, Theoretical; Molecular Mimicry; Oxidation-Reduction; Plasmodium; Reactive Oxygen Species; Thermodynamics	2011
Extracellular heme enhances the antimalarial activity of artemisinin. Biological & pharmaceutical bulletin, 2012, Volume: 35, Issue:1 Topics: Antimalarials; Antioxidants; Artemisia; Artemisinins; Chloroquine; Cholesterol, LDL; Fluorescence; Heme; Hemin; Humans; Lipid Peroxidation; Mefloquine; Oxidants; Oxidation-Reduction; Plasmodium falciparum; Quinine; Tryptophan; Vitamin E	2012
Evidence for the contribution of the hemozoin synthesis pathway of the murine Plasmodium yoelii to the resistance to artemisinin-related drugs. PloS one, 2012, Volume: 7, Issue:3 Topics: Amino Acid Sequence; Animals; Antimalarials; Artemisinins; Drug Resistance; Drug Resistance, Multiple; Female; Heme; Hemeproteins; Lysosomes; Mice; Molecular Sequence Data; Plasmodium yoelii; Protozoan Proteins	2012
Detection, characterization, and screening of heme-binding molecules by mass spectrometry for malaria drug discovery. Analytical chemistry, 2012, Apr-03, Volume: 84, Issue:7 Topics: Antimalarials; Artemisinins; Drug Discovery; Heme; Mass Spectrometry	2012
Targeting heme for the identification of cytotoxic agents. Anti-cancer agents in medicinal chemistry, 2013, Volume: 13, Issue:3 Topics: Antimalarials; Antineoplastic Agents; Artemisinins; Cell Line, Tumor; Cyanides; Drug Discovery; Heme; High-Throughput Screening Assays; Humans; Imidazoles; Leukemia, Promyelocytic, Acute; Molecular Targeted Therapy; Nitriles; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyridines; Quinolines	2013
Solid-state electrochemical assay of heme-binding molecules for screening of drugs with antimalarial potential. Analytical chemistry, 2013, Apr-16, Volume: 85, Issue:8 Topics: Antimalarials; Artemisinins; Carbon; Cell Extracts; Drug Discovery; Electrochemical Techniques; Electrodes; Erythrocytes; Ferric Compounds; Heme; Hemoglobins; Humans; Hydrogen-Ion Concentration; Ligands; Oxidation-Reduction; Praziquantel; Quinine; Structure-Activity Relationship	2013
Pro-oxidant properties of indolone-N-oxides in relation to their antimalarial properties. Journal of inorganic biochemistry, 2013, Volume: 126 Topics: Antimalarials; Artemisinins; Chloroquine; Cyclic N-Oxides; Cysteine; Electron Spin Resonance Spectroscopy; Enzyme Activation; Erythrocyte Membrane; Heme; Hemin; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Iron; Models, Biological; Models, Chemical; Oxidation-Reduction; Protein-Tyrosine Kinases; Reactive Oxygen Species; Solutions; Syk Kinase	2013
Correlation between Plasmodium yoelii nigeriensis susceptibility to artemisinin and alkylation of heme by the drug. Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:8 Topics: Alkylation; Animals; Antimalarials; Artemisinins; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Resistance; Erythrocytes; Female; Heme; Malaria; Mice; Plasmodium yoelii; Protein Binding; Spleen	2013
A SAR and QSAR study of new artemisinin compounds with antimalarial activity. Molecules (Basel, Switzerland), 2013, Dec-30, Volume: 19, Issue:1 Topics: Antimalarials; Artemisinins; Cluster Analysis; Heme; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Molecular Structure; Parasitic Sensitivity Tests; Principal Component Analysis; Quantitative Structure-Activity Relationship; Static Electricity; Structure-Activity Relationship	2013
Molecular modelling based target identification for endo-peroxides class of antimalarials. Combinatorial chemistry & high throughput screening, 2015, Volume: 18, Issue:2 Topics: Amino Acid Sequence; Antimalarials; Artemisinins; Calcium-Transporting ATPases; Drug Design; Heme; Heterocyclic Compounds; Humans; Malaria, Falciparum; Models, Molecular; Molecular Docking Simulation; Molecular Sequence Data; Plasmodium falciparum; Sequence Alignment	2015
Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nature communications, 2015, Dec-22, Volume: 6 Topics: Antimalarials; Artemisinins; Chemical Engineering; Heme; Models, Molecular; Molecular Structure; Plasmodium falciparum; Protein Conformation; Protozoan Proteins	2015
Characterization of the Artemisinin Binding Site for Translationally Controlled Tumor Protein (TCTP) by Bioorthogonal Click Chemistry. Bioconjugate chemistry, 2016, Dec-21, Volume: 27, Issue:12 Topics: Alkylation; Artemisinins; Binding Sites; Click Chemistry; Heme; Mass Spectrometry; Molecular Docking Simulation; Mutagenesis, Site-Directed; Plasmodium falciparum; Protozoan Proteins; Reproducibility of Results	2016
Improved safety margin for embryotoxicity in rats for the new endoperoxide artefenomel (OZ439) as compared to artesunate. Birth defects research, 2018, 04-17, Volume: 110, Issue:7 Topics: Adamantane; Animals; Antimalarials; Artemisinins; Artesunate; Benzoxazines; Dose-Response Relationship, Drug; Embryo, Mammalian; Female; Fetal Development; Gestational Age; Heme; Organ Culture Techniques; Organogenesis; Peroxides; Phthalimides; Rats	2018
Quantification of Free Ferriprotoporphyrin IX Heme and Hemozoin for Artemisinin Sensitive versus Delayed Clearance Phenotype Plasmodium falciparum Malarial Parasites. Biochemistry, 2018, 12-26, Volume: 57, Issue:51 Topics: Animals; Antimalarials; Artemisinins; Drug Resistance; Erythrocytes; Heme; Hemeproteins; Hemin; Humans; Malaria, Falciparum; Phenotype; Plasmodium falciparum	2018
Monocyte phagocytosis of malaria β-haematin in the presence of artemisinin, amodiaquine, chloroquine, doxycycline, primaquine, pyrimethamine and quinine. Experimental parasitology, 2019, Volume: 197 Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Cell Count; Cell Line; Chloroquine; Doxycycline; Electron Probe Microanalysis; Heme; Hemeproteins; Humans; Leukocytes, Mononuclear; Mice; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Monocytes; Peroxidase; Phagocytosis; Primaquine; Pyrimethamine; Quinine; Spectrophotometry; Temperature; U937 Cells	2019
Genetic screens reveal a central role for heme metabolism in artemisinin susceptibility. Nature communications, 2020, 09-23, Volume: 11, Issue:1 Topics: Antimalarials; Artemisinins; Clustered Regularly Interspaced Short Palindromic Repeats; Drug Resistance; Gene Knockout Techniques; Genetic Testing; Heme; Humans; Malaria, Falciparum; Membrane Transport Proteins; Mutation; Plasmodium falciparum; Protozoan Proteins; Toxoplasma	2020
Artemisinin-Based Drugs Target the Plasmodium falciparum Heme Detoxification Pathway. Antimicrobial agents and chemotherapy, 2021, 03-18, Volume: 65, Issue:4 Topics: Antimalarials; Artemisinins; Heme; Hemeproteins; Pharmaceutical Preparations; Plasmodium falciparum	2021
Combating multi-drug resistant malaria parasite by inhibiting falcipain-2 and heme-polymerization: Artemisinin-peptidyl vinyl phosphonate hybrid molecules as new antimalarials. European journal of medicinal chemistry, 2021, Aug-05, Volume: 220 Topics: Antimalarials; Artemisinins; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Heme; Malaria; Molecular Structure; Organophosphonates; Parasitic Sensitivity Tests; Peptides; Plasmodium falciparum; Polymerization; Structure-Activity Relationship; Vinyl Compounds	2021
The Antagonizing Role of Heme in the Antimalarial Function of Artemisinin: Elevating Intracellular Free Heme Negatively Impacts Artemisinin Activity in Molecules (Basel, Switzerland), 2022, Mar-08, Volume: 27, Issue:6 Topics: Antimalarials; Artemisinins; Heme; Plasmodium falciparum	2022
A whole-genome scan for Artemisinin cytotoxicity reveals a novel therapy for human brain tumors. EMBO molecular medicine, 2023, 03-08, Volume: 15, Issue:3 Topics: Aminolevulinic Acid; Antimalarials; Artemisinins; Brain Neoplasms; Heme; Humans	2023
Antimalarial activity and sensitization of chrysosplenetin against artemisinin-resistant genotype Plasmodium berghei K173 potentially via dual-mechanism of maintaining host P-glycoprotein homeostasis mediated by NF-κB p52 or PXR/CAR signaling pathways and Phytotherapy research : PTR, 2023, Volume: 37, Issue:7 Topics: Animals; Antimalarials; Artemisinins; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; Heme; Homeostasis; Mice; Neoplasm Proteins; NF-kappa B p52 Subunit; Plasmodium berghei; Signal Transduction	2023
Why is Babesia not killed by artemisinin like Plasmodium? Parasites & vectors, 2023, Jun-08, Volume: 16, Issue:1 Topics: Artemisinins; Babesia; Babesiosis; Heme; Humans; Iron; Plasmodium yoelii	2023

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