aristolochic acid i has been researched along with phenanthrenes in 185 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 44 (23.78) | 18.7374 |
| 1990's | 78 (42.16) | 18.2507 |
| 2000's | 61 (32.97) | 29.6817 |
| 2010's | 2 (1.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Killion, K; Rao, KV; Tanrikut, Y | 1 |
| Franson, RC; Lattanzio, KS; Rosenthal, MD | 1 |
| Carganico, G; Ferrer, X; Moreno, JJ; Ortega, E | 1 |
| Fernando, RC; Nicklas, W; Schmeiser, HH; Wiessler, M | 1 |
| Scherf, HR; Schmeiser, HH; Wiessler, M | 1 |
| Bennett, CF; Chilton, FH; Sung, CM; Winkler, JD | 1 |
| Jarvis, WD; Judd, AM; MacLeod, RM; Spangelo, BL | 1 |
| Garner, RC; Lord, PG; Orton, TC; Routledge, MN | 1 |
| Bartram, CR; Buchmann, A; Janssen, JW; Lyons, J; Pfau, W; Scherf, HR; Schmeiser, HH; Wiessler, M | 1 |
| Pfau, W; Pool-Zobel, BL; von der Lieth, CW; Wiessler, M | 1 |
| Pfau, W; Schmeiser, HH; Wiessler, M | 2 |
| Franson, RC; Rosenthal, MD; Vishwanath, BS | 1 |
| Burlinson, B | 1 |
| Yang, XC | 1 |
| Chou, LD | 1 |
| Che, CT; Cordell, GA; Fong, HH; Mar, W; Pezzuto, JM; Swanson, SM | 1 |
| Mengs, U | 3 |
| Klein, M; Mengs, U | 1 |
| Fawzy, AA; Franson, RC; Vishwanath, BS | 1 |
| Schmeiser, HH; Schoepe, KB; Wiessler, M | 1 |
| Gowda, TV; Vishwanath, BS | 1 |
| Appu Rao, AG; Gowda, TV; Vishwanath, BS | 1 |
| Pool, BL; Schmeiser, HH; Wiessler, M | 2 |
| Krumbiegel, G; Roth, HJ | 1 |
| Gowda, TV; Kini, RM; Vishwanath, BS | 1 |
| Hallensleben, J; Krumbiegel, G; Mennicke, WH; Rittmann, N; Roth, HJ | 1 |
| Maier, P; Schawalder, H; Weibel, B | 1 |
| Chu, Y; Deng, WL; Guo, ZW; Li, RX; Li, ZH; Pan, DB; Wang, WL | 1 |
| Frei, H; Graf, U; Hall, CB; Juon, H; Würgler, FE | 1 |
| Maier, P; Schawalder, HP; Weibel, B; Zbinden, G | 1 |
| Lanzer, G; Tilz, GP | 1 |
| Siering, H; Siering, U | 1 |
| He, XQ; Li, CH; Xiang, ZX; Zhou, GF | 1 |
| Wang, WH; Zheng, JH | 1 |
| Feng, YX; Lin, SQ; Zhang, XQ | 1 |
| Przesang, R; Siering, H | 1 |
| Göggelmann, W; Robisch, G; Schimmer, O | 1 |
| Zimmermann, W | 1 |
| Bass, R; Grase, R; Hagemann, U; Schönhöfer, PS; Thiele, A | 1 |
| Abel, G; Schimmer, O | 1 |
| Barthel, U; Lutz, J; Metzenauer, P | 1 |
| Egger-Büssing, C; Möse, JR; Schmalzl, F; Stünzner, D; Zirm, M | 1 |
| Müller, HJ; Siering, H | 1 |
| Batsford, S; Kluthe, R; Vogt, A | 1 |
| Lloret, S; Moreno, JJ | 2 |
| Ou, LF; Teng, CM; Wu, TS | 1 |
| Chen, X; Li, H; Marumo, S; Sakagami, Y | 1 |
| Pate, JL; Townson, DH | 2 |
| Wiessler, M | 1 |
| But, P; Vanhaelen, M; Vanhaelen-Fastre, R; Vanherweghem, JL | 1 |
| Rajalakshmi, S; Rao, PM; Rossiello, MR; Sarma, DS | 1 |
| Chen, HA; Jing, RL; Xu, GJ; Xu, LS | 1 |
| Broschard, TH; Schmeiser, HH; von der Lieth, CW; Wiessler, M | 1 |
| Johnson, MS; Mitchell, R; Thomson, FJ; Wolbers, B | 1 |
| Fernando, RC; Frei, E; Pfau, W; Schmeiser, HH; Stiborová, M; Wiessler, M | 1 |
| Hölscher, C; Rose, SP | 1 |
| Lee, JS; Silvia, WJ | 1 |
| Fox, PL; Sa, G | 1 |
| Littner, MR; Lott, FD | 1 |
| Cohen, H; Fayard, JM; Lagarde, M; Laugier, C; Pageaux, JF; Tessier, C | 1 |
| Fernando, RC; Scherf, HR; Schmeiser, HH; Wiessler, M | 1 |
| Lindahl, M; Tagesson, C | 1 |
| Mitchell, R; Thomson, FJ | 1 |
| Bilia, AR; Marsili, A; Nieri, E; Pistelli, L; Scarpato, R | 1 |
| Laconi, E; Rajalakshmi, S; Rao, PM; Rossiello, MR; Sarma, DS | 1 |
| Mengs, U; Stotzem, CD | 1 |
| Götzl, E; Schimmer, O | 1 |
| Fernando, RC; Hadjiolov, D; Hadjiolov, N; Pirajnov, G; Schmeiser, HH; Wiessler, M | 1 |
| Broschard, TH; Schmeiser, HH; Wiessler, M | 1 |
| Bieler, CA; Cosyns, JP; Schmeiser, HH; van Ypersele de Strihou, C; Wiessler, M | 1 |
| Abramowicz, D; Depierreux, M; Tielemans, C; Vanherweghem, JL | 1 |
| Cohen, H; Fayard, JM; Lagarde, M; Laugier, C; Pageaux, JF; Rossini, GP; Tessier, C | 1 |
| Garde, J; Roldan, ER | 2 |
| Arita, Y; Hou, W; Morisset, J | 2 |
| Naderali, EK; Poyser, NL | 1 |
| Frei, E; Schmeiser, HH; Stiborova, M; Wiessler, M | 2 |
| Bieler, CA; Cosyns, JP; Schmeiser, HH; Stiborova, M; van Ypersele de Strihou, C; Wiessler, M | 1 |
| Burns, PD; Graf, GA; Hayes, SH; Silvia, WJ | 1 |
| Kasuno, K; Kuwahara, T; Maeda, K; Murata, M; Nishida, R; Okuda, J; Seta, K; Shinkai, S; Sugawara, A; Tanaka, A; Yoshida, T | 1 |
| Mau, SE; Vilhardt, H | 1 |
| López-Novoa, JM; Martínez-Salgado, C; Pérez de Lema, G; Rodríguez-Barbero, A; Rodríguez-Puyol, D | 1 |
| Lafrance, M; Li, J; Li, M; Simmons, DL; Tsang, BK | 1 |
| Andrioli, G; Bellavite, P; Benoni, G; Gaino, S; Lussignoli, S | 1 |
| Ishikawa, M; Kuwahara, T; Maeda, K; Murata, M; Nagae, T; Nishida, R; Okuda, J; Sawai, K; Seta, K; Shinkai, S; Sugawara, A; Tanaka, A; Yoshida, T | 1 |
| Chen, ST; Farber, JL; Pastorino, JG; Snyder, JW; Tafani, M | 1 |
| Jones, E; Stengel, B | 1 |
| Kanfer, JN; Singh, IN; Sitar, DS; Sorrentino, G | 1 |
| Bennett, JP; Fall, CP | 1 |
| Ernsberger, P | 1 |
| Norman, SJ; Poyser, NL | 2 |
| Bernard, AM; Bieler, CA; Cosyns, JP; Goebbels, RM; Liberton, V; Schmeiser, HH | 1 |
| Denson, DD; Eaton, DC; Middleton, P; Worrell, RT | 1 |
| Nagao, T; Sugita, Y; Urushidani, T | 1 |
| Chan, YY; Chen, ZT; Leu, YL; Wu, TS | 1 |
| Hamano, T; Kamakura, H; Satake, M; Sekita, S; Yasuda, I | 1 |
| Hashimoto, K; Higuchi, M; Komatsu, Y; Kubo, M; Makino, B; Maruno, M; Okada, M; Sakakibara, I | 1 |
| Huang, S; Konieczkowski, M; Schelling, JR; Sedor, JR | 1 |
| Cosyns, JP; Jadoul, M; Squifflet, JP; van Ypersele de Strihou, C; Wese, FX | 1 |
| De Broe, ME | 1 |
| Ain, R; Seshagiri, PB; Shivaji, S; Uma Devi, K | 1 |
| Motoo, Y | 1 |
| Callahan, L; DiMarco, A; Nethery, D; Stofan, D; Supinski, G | 1 |
| Bieler, CA; Breuer, A; Frei, E; Schmeiser, HH; Stiborová, M | 1 |
| Cook, T; Gower, P; Lord, GM; Pusey, CD; Tagore, R | 1 |
| But, PP; Ma, SC | 1 |
| Okada, M | 1 |
| Huang, JK; Jan, CR | 1 |
| Jan, CR; Tseng, CJ | 1 |
| Ibe, BO; Raj, JU; Sander, FC | 1 |
| Arlt, VM; Schmeiser, HH; Wiessler, M | 1 |
| Wang, C; Zhang, H | 1 |
| Kuwahara, T; Maeda, K; Nishida, R; Sugawara, A; Tanaka, A | 1 |
| Abramowicz, D; Arlt, VM; Bieler, CA; De Pauw, L; Depierreux, MF; Martinez, MC; Nortier, JL; Petein, M; Schmeiser, HH; Vanherweghem, JL; Vereerstraeten, P | 1 |
| Kessler, DA | 1 |
| Kuwahara, T; Nishida, R; Tanaka, A; Yokoi, H | 1 |
| AlKhalili, O; Denson, DD; Eaton, DC; Wang, X; Worrell, RT | 1 |
| Chiang, HT; Li, HF; Wu, SN | 1 |
| Labow, RS; Meek, E; Santerre, JP | 1 |
| Endmeir, R; Krumme, B; Vanhaelen, M; Walb, D | 1 |
| Arlt, VM; Pfeifer, GP; Schmeiser, HH | 1 |
| Cheng, JS; Chou, KJ; Jan, CR; Lee, KC; Tang, KY; Tseng, LL; Wang, JL | 1 |
| Lu, W | 1 |
| Li, YM | 1 |
| Ong, ES; Woo, SO; Yong, YL | 1 |
| Brown, AM; Burke, WJ; Conway, AD; Jain, JC; Kristal, BS; Li, SW; Ulluci, PA | 1 |
| Brown, H; Capoor, M; Davis, A; Gbedemah, A; Glendinning, JI; Long, E | 1 |
| Goto, M; Koshikawa, M; Kuwahara, T; Nishida, R; Tanaka, A; Yoshida, T | 1 |
| Bernard, AM; Cosyns, JP; Dehoux, JP; Goebbels, RM; Guiot, Y; Robert, A; van Ypersele de Strihou, C | 1 |
| Schwetz, BA | 1 |
| Benos, DJ; Bubien, JS; Fuller, CM; Smith, PR | 1 |
| Bao, HF; Denson, DD; Eaton, DC; Worrell, RT | 1 |
| Arlt, VM; Cosyns, J; Pfohl-Leszkowicz, A; Schmeiser, HH | 1 |
| Kim, JM; Manchanda, R; Tsang, BK | 1 |
| Ong, ES; Woo, SO | 1 |
| Breuer, A; Frei, E; Schmeiser, HH; Stiborová, M; Wiessler, M | 1 |
| Carnevale, KA; Cathcart, MK | 1 |
| Fox, JW; Harris, RJ; Kamiguti, AS; Laing, GD; Sundell, IB; Theakston, RD; Treweeke, AT; Warrell, DA; Zuzel, M | 1 |
| Arlt, VM; Beauwens, R; Boom, A; Devuyst, O; Lebeau, C; Schmeiser, HH; Verroust, PJ | 1 |
| Domdom, S; Glendinning, JI; Long, E | 1 |
| Bhowmik, DM; Cosyns, JP; Daugirdas, J; Frohnert, PP; Gregory, MC; Jha, V; Solez, K | 1 |
| Arlt, VM; Bieler, CA; But, PP; Cosyns, JP; Gillerot, G; Jadoul, M; Schmeiser, HH; van Ypersele De Strihou, C | 1 |
| Hara, M; Kajiyama, H; Kamatani, N; Kawaguchi, Y; Nishimagi, E; Terai, C | 1 |
| Arlt, VM; Cook, T; Lord, GM; Pusey, CD; Schmeiser, HH; Williams, G | 1 |
| Huang, Q; Zhang, X; Zheng, F | 1 |
| Chen, W; Chen, Y; Li, A | 1 |
| Bo, Y; Gao, R; Li, X; Liu, Y; Zheng, D; Zheng, F | 1 |
| De Prez, EG; Debelle, FD; Deschodt-Lanckman, MM; Garbar, CH; Nortier, JL; Salmon, IJ; Vanherweghem, JL; Vienne, AR | 1 |
| Deng, JF; Hwang, DF; Lee, TY; Wu, ML | 1 |
| Abramova, NA; Bennett, JP; Cassarino, DS; Khan, SM; Painter, TW | 1 |
| Cosyns, JP | 1 |
| Cook, T; Cronin, AJ; Kite, GC; Lord, GM; Maidment, G; Pusey, CD; Simmonds, MS | 1 |
| Kite, GC; Leon, C; Simmonds, MS; Yule, MA | 1 |
| Chen, A; Chu, P; Lin, SH; Lin, YF; Yang, SS | 1 |
| Lampert, N; Xu, Y | 1 |
| Nortier, J | 1 |
| Hayashi, M; Honma, M; Kohara, A; Ohwada, T; Suzuki, T | 1 |
| Frei, E; Schmeiser, HH; Sopko, B; Stiborová, M; Wiessler, M | 1 |
| Frei, E; Hájek, M; Schmeiser, HH; Stiborová, M | 1 |
| Davis, A; Glendinning, JI; Ramaswamy, S | 1 |
| Betzel, Ch; Chandra, V; Jasti, J; Kaur, P; Singh, TP; Srinivasan, A | 1 |
| Arlt, VM; Ceovic, S; Cosyns, JP; Ferluga, D; Pfohl-Leszkowicz, A; Schmeiser, HH; Stiborova, M; Vukelic, M | 1 |
| FILITIS, LN; MASSAGETOV, PS | 1 |
| HEDWALL, PR; PETERS, G | 1 |
| MOESE, JR | 1 |
| MOSER, H | 1 |
| BRODOVSKY, H; JACKSON, L; KOFMAN, S; WEISS, A | 1 |
| JUMMEL, F | 1 |
| KUPCHAN, SM; WORMSER, HC | 1 |
| Cai, SQ; Li, XM; Liu, GX; Ma, CM; Shang, MY; Su, T; Wang, X; Wen, YJ; Zhang, CY | 1 |
| Cai, SQ; Li, XM; Su, T; Tang, JW; Wang, X; Wen, YJ; Zhang, CY | 1 |
| Cheng, M; Liu, X; Liu, Y; Xiao, H | 2 |
| Su, GC; Wu, PL; Wu, TS | 1 |
2 review(s) available for aristolochic acid i and phenanthrenes
| Article | Year |
|---|---|
DNA adducts of pyrrolizidine alkaloids, nitroimidazoles and aristolochic acid.
Topics: Animals; Antineoplastic Agents; Aristolochic Acids; Carcinogens; DNA; DNA Adducts; Humans; Mutagens; Nitroimidazoles; Phenanthrenes; Pyrrolizidine Alkaloids | 1994 |
Progressive interstitial renal fibrosis due to Chinese herbs in a patient with calcinosis Raynaud esophageal sclerodactyly telangiectasia (CREST) syndrome.
Topics: Aristolochic Acids; Biopsy; Chromatography, High Pressure Liquid; CREST Syndrome; Disease Progression; DNA; Drugs, Chinese Herbal; Female; Fibrosis; Humans; Middle Aged; Mutagens; Nephritis, Interstitial; Phenanthrenes | 2001 |
1 trial(s) available for aristolochic acid i and phenanthrenes
| Article | Year |
|---|---|
Effects of steroids on the progression of renal failure in chronic interstitial renal fibrosis: a pilot study in Chinese herbs nephropathy.
Topics: Aristolochic Acids; Case-Control Studies; Disease Progression; Drugs, Chinese Herbal; Female; Fibrosis; Follow-Up Studies; Glucocorticoids; Humans; Kidney; Middle Aged; Nephritis, Interstitial; Phenanthrenes; Pilot Projects; Prednisolone; Renal Insufficiency; Time Factors | 1996 |
182 other study(ies) available for aristolochic acid i and phenanthrenes
| Article | Year |
|---|---|
Fluorometric and GLC analyses of aristolochic acid.
Topics: Aniline Compounds; Aristolochic Acids; Chromatography, Gas; Chromatography, Thin Layer; Dioxolanes; Fluorometry; Lactams; Methylation; Nitro Compounds; Oxidation-Reduction; Phenanthrenes; Plants; Spectrophotometry, Ultraviolet | 1975 |
The effects of the phospholipase A2 inhibitors aristolochic acid and PGBx on A23187-stimulated mobilization of arachidonate in human neutrophils are overcome by diacylglycerol or phorbol ester.
Topics: Arachidonic Acid; Aristolochic Acids; Calcimycin; Diglycerides; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phenanthrenes; Phosphatidate Phosphatase; Phospholipase D; Phospholipases A; Phospholipases A2; Polymers; Prostaglandins B; Sphingosine; Superoxides; Tetradecanoylphorbol Acetate | 1992 |
PLA2-induced oedema in rat skin and histamine release in rat mast cells. Evidence for involvement of lysophospholipids in the mechanism of action.
Topics: Animals; Aristolochic Acids; Cytoplasmic Granules; Dexamethasone; Edema; Histamine Release; In Vitro Techniques; Indomethacin; Lysophospholipids; Male; Mast Cells; Phenanthrenes; Phospholipases A; Phospholipases A2; Quinacrine; Rats; Rats, Inbred Strains; Skin | 1992 |
Detection and quantitation of dG-AAI and dA-AAI adducts by 32P-postlabeling methods in urothelium and exfoliated cells in urine of rats treated with aristolochic acid I.
Topics: Adenosine; Animals; Aristolochic Acids; Autoradiography; Carcinogens; Deoxyadenosines; Deoxyguanosine; DNA; Enterobacteriaceae; Guanosine; Isotope Labeling; Male; Phenanthrenes; Phosphorus Radioisotopes; Rats; Rats, Wistar; Single-Strand Specific DNA and RNA Endonucleases; Urinary Bladder; Urinary Tract; Urine | 1992 |
Activating mutations at codon 61 of the c-Ha-ras gene in thin-tissue sections of tumors induced by aristolochic acid in rats and mice.
Topics: Animals; Aristolochic Acids; Base Sequence; Codon; DNA, Neoplasm; Female; Genes, ras; Male; Mice; Molecular Sequence Data; Mutagens; Mutation; Neoplasms, Experimental; Phenanthrenes; Polymerase Chain Reaction; Rats; Rats, Inbred Strains | 1991 |
Characterization of CoA-independent transacylase activity in U937 cells.
Topics: Acyltransferases; Arachidonic Acid; Arachidonic Acids; Aristolochic Acids; Cell Line; Chromatography, High Pressure Liquid; Dexamethasone; Diethyl Pyrocarbonate; Edetic Acid; Humans; Hydrogen-Ion Concentration; Microsomes; Phenanthrenes; Quinacrine | 1991 |
Induction of interleukin-6 release by interleukin-1 in rat anterior pituitary cells in vitro: evidence for an eicosanoid-dependent mechanism.
Topics: Animals; Arachidonic Acid; Aristolochic Acids; Benzoquinones; Cells, Cultured; Cyclooxygenase Inhibitors; Eicosanoids; Ethacrynic Acid; Female; Glycerylphosphorylcholine; Interleukin-1; Interleukin-6; Lipoxygenase Inhibitors; Masoprocol; Organic Chemicals; Phenanthrenes; Phospholipases A; Phospholipases A2; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains; Signal Transduction | 1991 |
Effect of butylated hydroxyanisole on the level of DNA adduction by aristolochic acid in the rat forestomach and liver.
Topics: Animals; Aristolochic Acids; Butylated Hydroxyanisole; Carcinogens; DNA; Gastric Mucosa; Liver; Male; Phenanthrenes; Rats; Stomach | 1990 |
Aristolochic acid activates ras genes in rat tumors at deoxyadenosine residues.
Topics: Animals; Aristolochic Acids; Base Sequence; Carcinogens; Codon; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Genes, ras; Male; Molecular Sequence Data; Mutation; Neoplasms, Experimental; Oligonucleotide Probes; Phenanthrenes; Polymerase Chain Reaction; Rats; Rats, Inbred Strains | 1990 |
The structural basis for the mutagenicity of aristolochic acid.
Topics: Aristolochic Acids; Mutagenicity Tests; Mutagens; Phenanthrenes; Salmonella typhimurium | 1990 |
Aristolochic acid binds covalently to the exocyclic amino group of purine nucleotides in DNA.
Topics: Aristolochic Acids; Carcinogens; Chromatography, High Pressure Liquid; DNA; Magnetic Resonance Spectroscopy; Mutagens; Phenanthrenes; Purine Nucleotides | 1990 |
32P-postlabelling analysis of the DNA adducts formed by aristolochic acid I and II.
Topics: Animals; Aristolochic Acids; Autoradiography; Carcinogens; Chromatography, High Pressure Liquid; DNA; Male; Phenanthrenes; Phosphorus Radioisotopes; Rats; Rats, Inbred Strains; Tissue Distribution; Xanthine Oxidase | 1990 |
Effects of aristolochic acid on phospholipase A2 activity and arachidonate metabolism of human neutrophils.
Topics: Arachidonic Acid; Arachidonic Acids; Aristolochic Acids; Calcimycin; Dose-Response Relationship, Drug; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Neutrophils; Phenanthrenes; Phospholipases; Phospholipases A; Phospholipases A2; Platelet Activating Factor | 1989 |
An in vivo unscheduled DNA synthesis (UDS) assay in the rat gastric mucosa: preliminary development.
Topics: Animals; Aristolochic Acids; Carcinogenicity Tests; Carcinogens; Chlorohydrins; DNA; DNA Replication; Epichlorohydrin; Gastric Mucosa; In Vitro Techniques; Indomethacin; Male; Methylnitronitrosoguanidine; Phenanthrenes; Rats; Rats, Inbred Strains; Reference Values | 1989 |
[Exploratory study on various parts of Aristolochia manshuriensis for medical use].
Topics: Aristolochic Acids; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Phenanthrenes; Plant Extracts; Plants, Medicinal | 1986 |
[Determination of aristolochic acid in radix Stephaniae tetradrae (Aristolochia fangchi)].
Topics: Antineoplastic Agents, Phytogenic; Aristolochic Acids; Chromatography, Thin Layer; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Phenanthrenes; Plants, Medicinal | 1986 |
Evaluation of the mutagenic and cytostatic potential of aristolochic acid (3,4-methylenedioxy-8-methoxy-10-nitrophenanthrene-1-carboxylic acid) and several of its derivatives.
Topics: Animals; Aristolochic Acids; Biotransformation; Cell Line; Cricetinae; Cricetulus; Female; Fibroblasts; Mutagenicity Tests; Ovary; Phenanthrenes; Rats; Salmonella typhimurium; Tumor Cells, Cultured | 1988 |
Tumour induction in mice following exposure to aristolochic acid.
Topics: Animals; Aristolochic Acids; Female; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Phenanthrenes; Rats | 1988 |
Genotoxic effects of aristolochic acid in the mouse micronucleus test.
Topics: Animals; Aristolochic Acids; Bone Marrow; Female; Male; Mice; Micronucleus Tests; Mutagens; Phenanthrenes | 1988 |
Edema-inducing activity of phospholipase A2 purified from human synovial fluid and inhibition by aristolochic acid.
Topics: Acetophenones; Animals; Aristolochic Acids; Edema; Enzyme Activation; Female; Humans; Male; Mice; Phenanthrenes; Phospholipases; Synovial Fluid | 1988 |
DNA adduct formation of aristolochic acid I and II in vitro and in vivo.
Topics: Animals; Aristolochic Acids; Carcinogens; DNA; In Vitro Techniques; Male; Phenanthrenes; Rats; Rats, Inbred Strains; Tissue Distribution | 1988 |
Interaction of aristolochic acid with Vipera russelli phospholipase A2: its effect on enzymatic and pathological activities.
Topics: Animals; Aristolochic Acids; Edema; Mice; Phenanthrenes; Phosphatidylcholines; Phospholipases; Phospholipases A; Phospholipases A2; Viper Venoms | 1987 |
Interaction of phospholipase A2 from Vipera russelli venom with aristolochic acid: a circular dichroism study.
Topics: Aristolochic Acids; Circular Dichroism; Phenanthrenes; Phospholipases; Phospholipases A; Phospholipases A2; Viper Venoms | 1987 |
Identification and mutagenicity of metabolites of aristolochic acid formed by rat liver.
Topics: Animals; Aristolochic Acids; Kinetics; Magnetic Resonance Spectroscopy; Microsomes, Liver; Mutagenicity Tests; Mutagens; Mutation; Phenanthrenes; Rats; Salmonella typhimurium; Spectrophotometry | 1986 |
[Partial synthesis of aristolochic acid I and II derivatives as reference materials for metabolite production in the rat].
Topics: Animals; Aristolochic Acids; Biotransformation; Magnetic Resonance Spectroscopy; Phenanthrenes; Rats | 1987 |
Acute toxicity of aristolochic acid in rodents.
Topics: Animals; Antineoplastic Agents; Aristolochic Acids; Digestive System; Female; Injections, Intravenous; Intubation, Gastrointestinal; Kidney Tubules; Lethal Dose 50; Male; Mice; Phenanthrenes; Rats; Thymus Gland | 1987 |
Characterization of three edema-inducing phospholipase A2 enzymes from habu (Trimeresurus flavoviridis) venom and their interaction with the alkaloid aristolochic acid.
Topics: Animals; Aristolochic Acids; Biological Assay; Chemical Phenomena; Chemistry; Chromatography, Gel; Edema; Hemolysis; Molecular Weight; Phenanthrenes; Phosphatidylcholines; Phospholipases; Phospholipases A; Phospholipases A2; Viper Venoms | 1987 |
Studies on the metabolism of aristolochic acids I and II.
Topics: Animals; Aristolochic Acids; Biotransformation; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Feces; Guinea Pigs; Male; Mutagens; Phenanthrenes; Rabbits; Rats; Rats, Inbred Strains; Species Specificity | 1987 |
Low oxygen tension, as found in tissues in vivo, alters the mutagenic activity of aristolochic acid I and II in primary fibroblast-like rat cells in vitro.
Topics: Animals; Aristolochic Acids; Cells, Cultured; Fibroblasts; Granulation Tissue; Male; Mutagenicity Tests; Oxygen; Partial Pressure; Phenanthrenes; Rats; Rats, Inbred Strains | 1987 |
[Stepwise discriminant analysis on the relationship of immunostimulative activities and chemical structure of substituted cinnamic acids].
Topics: Animals; Antineoplastic Agents; Aristolochic Acids; Bayes Theorem; Cinnamates; Immunity, Cellular; Macrophage Activation; Mice; Phagocytosis; Phenanthrenes; Structure-Activity Relationship | 1985 |
Aristolochic acid is mutagenic and recombinogenic in Drosophila genotoxicity tests.
Topics: Animals; Antineoplastic Agents; Aristolochic Acids; Doxorubicin; Drosophila melanogaster; Female; Genes, Lethal; Genes, Recessive; Genotype; Male; Mutagenicity Tests; Mutagens; Phenanthrenes; Recombination, Genetic; Sex Chromosomes | 1985 |
Aristolochic acid induces 6-thioguanine-resistant mutants in an extrahepatic tissue in rats after oral application.
Topics: Administration, Oral; Animals; Aristolochic Acids; Drug Resistance; Granuloma; Hypoxanthine Phosphoribosyltransferase; Inactivation, Metabolic; Male; Methylnitronitrosoguanidine; Mutagenicity Tests; Mutagens; Phenanthrenes; Rats; Rats, Inbred Strains; Thioguanine | 1985 |
[Immunotherapy II: clinical investigations for the induction and activity of interferon (author's transl)].
Topics: Aristolochic Acids; Dioxolanes; Humans; Inflammation; Interferons; Leukemia; Neoplasms; Phenanthrenes; Poly I-C; Rosette Formation; Virus Diseases | 1980 |
[Modification of the leukocyte adherence inhibition test by prednisolone and aristolochic acid].
Topics: Antineoplastic Agents; Aristolochic Acids; Cell Adhesion; Humans; Immunity, Cellular; Immunologic Techniques; Leukocyte Adherence Inhibition Test; Lymphocytes; Phenanthrenes; Prednisolone | 1984 |
Mutagenicity of the two main components of commercially available carcinogenic aristolochic acid in Salmonella typhimurium.
Topics: Aristolochic Acids; Mutagenicity Tests; Mutagens; Nitroreductases; Oxidoreductases; Phenanthrenes; Salmonella typhimurium | 1984 |
[Pharmacokinetic studies on aristolochic acid in rats by an ultraviolet spectrophotometric method].
Topics: Animals; Antineoplastic Agents; Aristolochic Acids; Intestinal Absorption; Kinetics; Male; Phenanthrenes; Rats; Spectrophotometry, Ultraviolet; Tissue Distribution | 1984 |
[The pregnancy terminating effect and toxicity of an active constituent of Aristolochia mollissima Hance, aristolochic acid A].
Topics: Abortifacient Agents; Animals; Aristolochic Acids; China; Contraceptive Agents; Dogs; Embryo Implantation; Female; Male; Mice; Phenanthrenes; Plants, Medicinal; Pregnancy; Rats | 1984 |
[Botanical and pharmacognostical studies of Chinese Aristolochia: resource utilization].
Topics: Aristolochic Acids; China; Chromatography, Thin Layer; Phenanthrenes; Plants, Medicinal | 1983 |
[Modification of antibody formation in animal experiments by glucocorticoids and aristolochic acid].
Topics: Animals; Antibodies, Bacterial; Antibody Formation; Aristolochic Acids; Bone Marrow Examination; Coxiella; Drug Therapy, Combination; Glucocorticoids; Guinea Pigs; Leukocyte Count; Lymphocytes; Phenanthrenes; Rabbits | 1984 |
Aristolochic acid is a direct mutagen in Salmonella typhimurium.
Topics: Aristolochic Acids; Mutagenicity Tests; Mutagens; Phenanthrenes; Salmonella typhimurium | 1982 |
[From phytotherapeuticum to phytopharmacon].
Topics: Animals; Aristolochic Acids; Dioxolanes; Humans; Immunity, Cellular; Medicine, Traditional; Phagocytosis; Pharmacognosy; Phenanthrenes; Plants, Medicinal | 1981 |
[Problems of drug safety: aristolochic acid].
Topics: Animals; Aristolochic Acids; Consumer Product Safety; Germany, West; Legislation as Topic; Neoplasms; Phenanthrenes; Rats; Rats, Inbred Strains | 1982 |
On the histopathogenesis of rat forestomach carcinoma caused by aristolochic acid.
Topics: Animals; Antineoplastic Agents; Aristolochic Acids; Hyperplasia; Male; Neoplasms, Experimental; Papilloma; Phenanthrenes; Rats; Rats, Inbred Strains; Stomach; Stomach Neoplasms | 1983 |
Induction of structural chromosome aberrations and sister chromatid exchanges in human lymphocytes in vitro by aristolochic acid.
Topics: Aristolochic Acids; Carcinogens; Chromosome Aberrations; Crossing Over, Genetic; Dose-Response Relationship, Drug; Humans; Lymphocytes; Metaphase; Phenanthrenes; Sister Chromatid Exchange | 1983 |
Variation in toxicity of Escherichia coli endotoxin after treatment with perfluorated blood substitutes in mice.
Topics: Animals; Aristolochic Acids; Blood Substitutes; Endotoxins; Escherichia coli; Female; Fluorocarbons; Hydrocortisone; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; p-Methoxy-N-methylphenethylamine; Phenanthrenes; Zymosan | 1982 |
[Effect of aristolochic acid on herpes simplex infection of the rabbit eye].
Topics: Animals; Antiviral Agents; Aqueous Humor; Aristolochic Acids; Dioxolanes; Eye; Eye Proteins; Keratitis, Dendritic; Phenanthrenes; Rabbits | 1980 |
[Antagonistic effects of glucocorticoids and aristolochic acid on the immunocyte adherence phenomenon (author's transl)].
Topics: Animals; Aristolochic Acids; Drug Interactions; Glucocorticoids; Lymphocytes; Phenanthrenes; Prednisolone; Rats; Rats, Inbred Strains; Rosette Formation | 1981 |
[Double blind study of the influence of aristolochic acid on granulocyte phagocytic activity].
Topics: Adult; Aristolochic Acids; Blood Bactericidal Activity; Double-Blind Method; Granulocytes; Humans; Male; Phagocytosis; Phenanthrenes; Time Factors | 1982 |
Effect of nonapeptide fragments of uteroglobin and lipocortin I on oedema and mast cell degranulation.
Topics: Animals; Annexin A1; Aristolochic Acids; Carrageenan; Cell Degranulation; Chlorpheniramine; Dexamethasone; Disease Models, Animal; Edema; Elapid Venoms; Elapidae; Histamine Release; Indomethacin; Inflammation; Injections, Intradermal; Male; Mast Cells; Peptide Fragments; Phenanthrenes; Phospholipases A; Phospholipases A2; Rats; Rats, Sprague-Dawley; Uteroglobin | 1994 |
Aristolochic acids, aristolactam alkaloids and amides from Aristolochia kankauensis.
Topics: Alkaloids; Amides; Aristolochic Acids; Cell Survival; Magnetic Resonance Spectroscopy; Mass Spectrometry; Phenanthrenes; Plants; Platelet Aggregation Inhibitors; Structure-Activity Relationship | 1994 |
Eleven aristolochic acid derivatives from Aristolochia cinnabarina.
Topics: Aristolochic Acids; Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Medicine, Chinese Traditional; Molecular Sequence Data; Phenanthrenes; Plants, Medicinal; Spectrometry, Mass, Fast Atom Bombardment | 1994 |
Regulation of prostaglandin synthesis by interleukin-1 beta in cultured bovine luteal cells.
Topics: Animals; Arachidonic Acid; Aristolochic Acids; Cattle; Cells, Cultured; Cycloheximide; Dactinomycin; Dinoprost; Female; Interleukin-1; Luteal Cells; p-Methoxy-N-methylphenethylamine; Phenanthrenes; Phospholipases A; Phospholipases A2; Progesterone; Prostaglandins; Recombinant Proteins; Type C Phospholipases | 1994 |
Immunochemical relatedness between secretory phospholipase A2 and intracellular phospholipase A2 activity linked with arachidonic acid mobilization in macrophages.
Topics: Acetophenones; Animals; Arachidonic Acid; Aristolochic Acids; Blotting, Western; Cross Reactions; Crotalid Venoms; Crotalus; Elapid Venoms; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Immune Sera; Macrophages, Peritoneal; Male; Masoprocol; Mice; Molecular Weight; Pancreas; Phagocytosis; Phenanthrenes; Phospholipases A; Phospholipases A2; Rats; Rats, Sprague-Dawley; Swine; Tretinoin; Zymosan | 1994 |
Identification of aristolochic acid in Chinese herbs.
Topics: Alkaloids; Aristolochic Acids; Belgium; Benzylisoquinolines; Drugs, Chinese Herbal; Humans; Kidney Diseases; Phenanthrenes | 1994 |
Similar patterns of hypomethylation in the beta-hydroxy-beta-methylglutaryl coenzyme A reductase gene in hepatic nodules induced by different carcinogens.
Topics: 1,2-Dimethylhydrazine; Animals; Aristolochic Acids; Carcinogens; Cell Cycle; Dimethylhydrazines; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Genes; Genes, myc; Genes, ras; Hydroxymethylglutaryl CoA Reductases; Liver Neoplasms; Male; Methylation; Phenanthrenes; Polymorphism, Restriction Fragment Length; Precancerous Conditions; Rats; Rats, Inbred F344 | 1994 |
[Determination of aristolochic acid I and total alkaloids in fangji].
Topics: Alkaloids; Aristolochic Acids; Chromatography, Thin Layer; Densitometry; Drugs, Chinese Herbal; Phenanthrenes; Species Specificity | 1994 |
Translesional synthesis on DNA templates containing site-specifically placed deoxyadenosine and deoxyguanosine adducts formed by the plant carcinogen aristolochic acid.
Topics: Aristolochic Acids; Base Sequence; Binding Sites; Carcinogens; Deoxyadenosines; Deoxyguanosine; DNA; DNA Adducts; DNA Damage; DNA Replication; DNA-Directed DNA Polymerase; Models, Molecular; Molecular Sequence Data; Neoplasms, Experimental; Oligonucleotides; Phenanthrenes; Sensitivity and Specificity; Templates, Genetic | 1994 |
Evidence for a role of phospholipase A2 in the mechanism of LHRH priming in rat anterior pituitary tissue.
Topics: Acetophenones; Aminobenzoates; Animals; Arachidonic Acid; Aristolochic Acids; Calcium; Chlorobenzoates; Cinnamates; Cycloheximide; Female; Gonadotropin-Releasing Hormone; In Vitro Techniques; Luteinizing Hormone; ortho-Aminobenzoates; Phenanthrenes; Phenothiazines; Phospholipases A; Phospholipases A2; Pituitary Gland, Anterior; Proestrus; Quinacrine; Rats; Rats, Wistar | 1994 |
Characterization of DNA adducts formed by aristolochic acids in the target organ (forestomach) of rats by 32P-postlabelling analysis using different chromatographic procedures.
Topics: Animals; Aristolochic Acids; Carcinogens; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; DNA; Gastric Mucosa; Male; Phenanthrenes; Phosphorus Radioisotopes; Rats; Rats, Sprague-Dawley | 1994 |
Inhibitors of phospholipase A2 produce amnesia for a passive avoidance task in the chick.
Topics: Amnesia; Animals; Aristolochic Acids; Avoidance Learning; Behavior, Animal; Brain; Chickens; Female; Male; Masoprocol; Phenanthrenes; Phospholipases A; Phospholipases A2; Synaptic Transmission | 1994 |
Cellular mechanisms mediating the stimulation of ovine endometrial secretion of prostaglandin F2 alpha in response to oxytocin: role of phospholipase A2.
Topics: Animals; Aristolochic Acids; Dinoprost; Endometrium; Female; In Vitro Techniques; Melitten; Ovariectomy; Oxytocin; Phenanthrenes; Phospholipases A; Phospholipases A2; Sheep; Stimulation, Chemical | 1994 |
Basic fibroblast growth factor-stimulated endothelial cell movement is mediated by a pertussis toxin-sensitive pathway regulating phospholipase A2 activity.
Topics: Animals; Aorta; Arachidonic Acid; Aristolochic Acids; Cattle; Cell Division; Cell Movement; Cells, Cultured; Cholera Toxin; DNA; Dose-Response Relationship, Drug; Endothelium, Vascular; Fibroblast Growth Factor 2; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Pertussis Toxin; Phenanthrenes; Phospholipases A; Phospholipases A2; Second Messenger Systems; Virulence Factors, Bordetella | 1994 |
Increase in filtration coefficient from actions of melittin on neutrophils in isolated rabbit lungs.
Topics: Analysis of Variance; Animals; Aristolochic Acids; Catalase; In Vitro Techniques; Lung; Melitten; Neutrophils; Perfusion; Phenanthrenes; Phospholipases A; Phospholipases A2; Pulmonary Circulation; Rabbits; Reactive Oxygen Species; Respiratory Distress Syndrome | 1994 |
Phospholipase A2 inhibitors regulate the proliferation of normal uterine cells.
Topics: Animals; Arachidonic Acid; Aristolochic Acids; Cell Division; Cells, Cultured; Culture Media; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Female; Kinetics; Lipoxygenase Inhibitors; Phenanthrenes; Phospholipases A; Phospholipases A2; Rats; Tritium; Uterus | 1994 |
Formation and persistence of specific purine DNA adducts by 32P-postlabelling in target and non-target organs of rats treated with aristolochic acid I.
Topics: Animals; Aristolochic Acids; Carcinogens; Deoxyadenosines; Deoxyguanosine; DNA; DNA Damage; Gastric Mucosa; Male; Phenanthrenes; Phosphorus Radioisotopes; Rats; Rats, Wistar; Stomach; Stomach Neoplasms; Tissue Distribution | 1993 |
Selective inhibition of group II phospholipase A2 by quercetin.
Topics: Animals; Aristolochic Acids; Chlorpromazine; Humans; Indomethacin; Pancreas; Phenanthrenes; Phospholipases A; Phospholipases A2; Quercetin; Shock, Septic; Substrate Specificity; Swine; Viper Venoms | 1993 |
Differential involvement of phospholipase A2 in phorbol ester-induced luteinizing hormone and growth hormone release from rat anterior pituitary tissue.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aminobenzoates; Animals; Arachidonic Acid; Aristolochic Acids; Chlorobenzoates; Cinnamates; Cyclohexanones; Cycloheximide; Enzyme Activation; Female; Growth Hormone; Indoles; Ionomycin; Isoquinolines; Luteinizing Hormone; Melitten; ortho-Aminobenzoates; Phenanthrenes; Phenothiazines; Phorbol 12,13-Dibutyrate; Phospholipases A; Phospholipases A2; Piperazines; Pituitary Gland, Anterior; Proestrus; Protein Kinase C; Quinacrine; Rats; Rats, Wistar; Signal Transduction; Staurosporine | 1993 |
Chemical constituents of Aristolochia rigida and mutagenic activity of aristolochic acid IV.
Topics: Animals; Aristolochic Acids; Chromatography, Thin Layer; Leukemia P388; Magnetic Resonance Spectroscopy; Mutagenicity Tests; Mutagens; Phenanthrenes; Plant Extracts; Plants, Medicinal; Salmonella typhimurium; Somalia | 1993 |
Induction of hepatic nodules in the rat by aristolochic acid.
Topics: Animals; Aristolochic Acids; Carcinogens; Cell Division; Cocarcinogenesis; Hepatectomy; Liver; Liver Neoplasms; Male; Necrosis; Orotic Acid; Phenanthrenes; Rats; Rats, Inbred F344 | 1993 |
Renal toxicity of aristolochic acid in rats as an example of nephrotoxicity testing in routine toxicology.
Topics: Animals; Aristolochic Acids; Body Weight; Carcinogens; Creatinine; Dose-Response Relationship, Drug; Female; Kidney; Kidney Diseases; Kidney Function Tests; Organ Size; Phenanthrenes; Rats; Rats, Wistar; Urea | 1993 |
Mutagenicity of aristolochic acids (I, II) and aristolic acid I in new YG strains in Salmonella typhimurium highly sensitive to certain mutagenic nitroarenes.
Topics: Aristolochic Acids; DNA Damage; Mutagenicity Tests; Phenanthrenes; Plant Extracts; Plasmids; Salmonella typhimurium; Structure-Activity Relationship | 1993 |
Effect of diallyl sulfide on aristolochic acid-induced forestomach carcinogenesis in rats.
Topics: Allyl Compounds; Animals; Antineoplastic Agents; Aristolochic Acids; Carcinogens; DNA; DNA Damage; Dose-Response Relationship, Drug; Male; Phenanthrenes; Rats; Stomach Neoplasms; Sulfides | 1993 |
Effect of site-specifically located aristolochic acid DNA adducts on in vitro DNA synthesis by human DNA polymerase alpha.
Topics: Aristolochic Acids; Base Sequence; Carcinogens; Deoxyribonucleotides; DNA; DNA Adducts; DNA Polymerase II; DNA Primers; DNA Replication; Humans; Molecular Sequence Data; Mutagenesis; Mutagens; Oligonucleotide Probes; Phenanthrenes; Templates, Genetic | 1995 |
Detection of DNA adducts formed by aristolochic acid in renal tissue from patients with Chinese herbs nephropathy.
Topics: Adult; Aristolochic Acids; DNA Adducts; Drugs, Chinese Herbal; Female; Humans; Kidney; Kidney Diseases; Phenanthrenes | 1996 |
The level of pancreatic PLA2 receptor is closely associated with the proliferative state of rat uterine stromal cells.
Topics: Animals; Aristolochic Acids; Binding Sites; Cell Division; Cells, Cultured; Enzyme Inhibitors; Female; Pancreas; Phenanthrenes; Phospholipases A; Phospholipases A2; Protein Binding; Rats; Receptors, Cell Surface; Receptors, Phospholipase A2; Stromal Cells; Swine; Uterus | 1996 |
rab 3-peptide stimulates exocytosis of the ram sperm acrosome via interaction with cyclic AMP and phospholipase A2 metabolites.
Topics: Acrosome; Amino Acid Sequence; Animals; Aristolochic Acids; Bucladesine; Calcimycin; Calcium; Cyclic AMP; Enzyme Inhibitors; Exocytosis; GTP-Binding Proteins; Lysophosphatidylcholines; Male; Molecular Sequence Data; Peptides; Phenanthrenes; Phospholipases A; Phospholipases A2; rab3 GTP-Binding Proteins; Sheep; Spermatozoa; Time Factors | 1996 |
Caerulein-stimulated arachidonic acid release in rat pancreatic acini: a diacylglycerol lipase affair.
Topics: Androstadienes; Animals; Arachidonic Acid; Aristolochic Acids; Carbachol; Cells, Cultured; Ceruletide; Cyclohexanones; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Estrenes; Kinetics; Lipoprotein Lipase; Lipoxygenase Inhibitors; Male; Pancreas; Phenanthrenes; Phospholipase D; Phospholipases A; Phospholipases A2; Pyrrolidinones; Quinacrine; Rats; Rats, Sprague-Dawley; Wortmannin | 1996 |
Mechanism of action of TNF-alpha-stimulated prostaglandin production in cultured bovine luteal cells.
Topics: Animals; Arachidonic Acid; Aristolochic Acids; Cattle; Cell Division; Cell Survival; Cells, Cultured; Corpus Luteum; Cycloheximide; Dactinomycin; Dinoprost; Enzyme Inhibitors; Female; Phenanthrenes; Phospholipases A; Phospholipases A2; Protein Synthesis Inhibitors; Tumor Necrosis Factor-alpha; Type C Phospholipases | 1996 |
Factors controlling prostaglandin production by guinea-pig endometrial cells.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aristolochic Acids; Calcimycin; Calcium; Cells, Cultured; Cycloheximide; Dinoprost; Dinoprostone; Endometrium; Epithelial Cells; Epithelium; Estradiol; Female; Guinea Pigs; Ionophores; Melitten; Phenanthrenes; Phospholipases A; Phospholipases A2; Progesterone; Prostaglandins; Protein Synthesis Inhibitors; Puromycin | 1996 |
Endogenous arachidonic acid release and pancreatic amylase secretion.
Topics: Amylases; Animals; Arachidonic Acid; Aristolochic Acids; Carbachol; Cyclohexanones; Enzyme Inhibitors; In Vitro Techniques; Lipoprotein Lipase; Male; Melitten; Pancreas; Phenanthrenes; Phospholipases A; Phospholipases A2; Quinacrine; Rats; Rats, Sprague-Dawley | 1997 |
Comparison of DNA adduct formation by aristolochic acids in various in vitro activation systems by 32P-post-labelling: evidence for reductive activation by peroxidases.
Topics: Animals; Aristolochic Acids; DNA Adducts; Hydrogen-Ion Concentration; Male; Microsomes; Oxidation-Reduction; Peroxidases; Phenanthrenes; Rats; Rats, Sprague-Dawley; Xanthine Oxidase; Zinc | 1997 |
32P-post-labelling analysis of DNA adducts formed by aristolochic acid in tissues from patients with Chinese herbs nephropathy.
Topics: Adult; Animals; Aristolochic Acids; DNA Adducts; Drugs, Chinese Herbal; Female; Humans; Kidney Diseases; Male; Middle Aged; Phenanthrenes; Rats; Rats, Wistar; Time Factors | 1997 |
Cellular mechanisms by which oxytocin stimulates uterine PGF2 alpha synthesis in bovine endometrium: roles of phospholipases C and A2.
Topics: Aluminum Chloride; Aluminum Compounds; Animals; Aristolochic Acids; Cattle; Chlorides; Dinoprost; Dose-Response Relationship, Drug; Endometrium; Enzyme Inhibitors; Female; Inositol Phosphates; Melitten; Organ Culture Techniques; Oxytocin; Phenanthrenes; Phospholipases A; Phospholipases A2; Type C Phospholipases | 1997 |
[Chinese herbs nephropathy in the Kansai area: a warning report].
Topics: Aristolochic Acids; Drugs, Chinese Herbal; Fanconi Syndrome; Female; Humans; Japan; Middle Aged; Phenanthrenes | 1997 |
Cross talk between substance P and melittin-activated cellular signaling pathways in rat lactotroph-enriched cell cultures.
Topics: Animals; Arachidonic Acid; Aristolochic Acids; Cells, Cultured; Enzyme Inhibitors; Female; Inositol 1,4,5-Trisphosphate; Isoenzymes; Male; Melitten; Phenanthrenes; Phospholipases A; Phospholipases A2; Pituitary Gland, Anterior; Prolactin; Protein Kinase C; Quinacrine; Rats; Rats, Wistar; Signal Transduction; Substance P; Tetradecanoylphorbol Acetate; Tritium | 1997 |
Involvement of phospholipase A2 in gentamicin-induced rat mesangial cell activation.
Topics: Acetates; Animals; Aristolochic Acids; Cell Division; Cell Survival; Cells, Cultured; Dinoprostone; Diterpenes; DNA; Enzyme Inhibitors; Gentamicins; Ginkgolides; Glomerular Mesangium; Kinetics; Lactones; Phenanthrenes; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Quinacrine; Rats; Rats, Wistar; Thymidine; Verapamil | 1997 |
Role and regulation of prostaglandin synthesis in the mitogenic response of ovarian granulosa cells to transforming growth factor alpha.
Topics: Aminobenzoates; Animals; Aristolochic Acids; Chickens; Chlorobenzoates; Cinnamates; Cyclooxygenase 2; Dinoprostone; DNA Replication; Enzyme Induction; Enzyme Inhibitors; Fatty Acids, Unsaturated; Female; Gene Expression Regulation; Granulosa Cells; Hydroxyeicosatetraenoic Acids; Indoles; Isoenzymes; Leukotrienes; Lipoxygenase Inhibitors; Lysophospholipids; Masoprocol; Mitosis; ortho-Aminobenzoates; Ovarian Follicle; Phenanthrenes; Phospholipases A; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Transforming Growth Factor alpha | 1997 |
Study on paradoxical effects of NSAIDs on platelet activation.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 12-Lipoxygenase; Aristolochic Acids; Calcium; Diclofenac; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flurbiprofen; Humans; In Vitro Techniques; Inflammation; Lipoxygenase Inhibitors; Masoprocol; Nitric Oxide; Phenanthrenes; Phospholipases A; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation | 1997 |
[Traditional remedy-induced Chinese herbs nephropathy showing rapid deterioration of renal function].
Topics: Adult; Aristolochic Acids; Drugs, Chinese Herbal; Female; Humans; Kidney; Kidney Diseases; Phenanthrenes | 1997 |
The overexpression of Bax produces cell death upon induction of the mitochondrial permeability transition.
Topics: Apoptosis; Aristolochic Acids; bcl-2-Associated X Protein; Caspase 3; Caspases; Cyclosporine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytochrome c Group; Cytosol; DNA Fragmentation; Ecdysterone; Enzyme Activation; Humans; Intracellular Membranes; Jurkat Cells; Mitochondria; Oligopeptides; Permeability; Phenanthrenes; Phospholipases A; Phospholipases A2; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Transfection | 1998 |
[End-stage renal insufficiency associated with Chinese herbal consumption in France].
Topics: Adult; Aristolochic Acids; Belgium; Drugs, Chinese Herbal; Female; France; Humans; Kidney Failure, Chronic; Middle Aged; Phenanthrenes | 1998 |
(-)Nicotine inhibits the activations of phospholipases A2 and D by amyloid beta peptide.
Topics: Acetophenones; Amyloid beta-Peptides; Arachidonic Acids; Aristolochic Acids; Brain; Brain Chemistry; Cells, Cultured; Cotinine; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Hexamethonium; Kainic Acid; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phenanthrenes; Phospholipase D; Phospholipases A; Phospholipases A2; Quisqualic Acid; Tubocurarine; Type C Phospholipases | 1998 |
MPP+ induced SH-SY5Y apoptosis is potentiated by cyclosporin A and inhibited by aristolochic acid.
Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; Aristolochic Acids; Cyclosporine; Drug Synergism; Enzyme Inhibitors; Mitochondria; Neurons; Phenanthrenes; Phospholipases A; Phospholipases A2; Tumor Cells, Cultured | 1998 |
Arachidonic acid release from PC12 pheochromocytoma cells is regulated by I1-imidazoline receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arachidonic Acid; Aristolochic Acids; Benzofurans; Enzyme Inhibitors; Guanabenz; Imidazoles; Imidazoline Receptors; PC12 Cells; Phenanthrenes; Phospholipases A; Phospholipases A2; Rats; Receptors, Drug | 1998 |
Prostaglandin production by guinea-pig placenta and other uterine tissues during mid-pregnancy.
Topics: Animals; Aristolochic Acids; Endometrium; Enzyme Inhibitors; Extraembryonic Membranes; Female; Guinea Pigs; Male; Phenanthrenes; Phospholipases A; Phospholipases A2; Placenta; Pregnancy; Pregnancy, Animal; Prostaglandins; Thimerosal | 1998 |
Chinese herbs nephropathy-associated slimming regimen induces tumours in the forestomach but no interstitial nephropathy in rats.
Topics: Animals; Anti-Obesity Agents; Aristolochic Acids; Carcinogens; Drugs, Chinese Herbal; Female; Fibrin; Male; Nephritis, Interstitial; Phenanthrenes; Rats; Rats, Wistar; Stomach Neoplasms | 1998 |
Ca2+ sensitivity of BK channels in GH3 cells involves cytosolic phospholipase A2.
Topics: Arachidonic Acid; Aristolochic Acids; Bradykinin; Calcium; Cell Line; Cytosol; Electrophysiology; Enzyme Inhibitors; Ion Channels; Kinetics; Oligonucleotides, Antisense; Phenanthrenes; Phospholipases A; Phospholipases A2 | 1999 |
Nonspecific effects of the pharmacological probes commonly used to analyze signal transduction in rabbit parietal cells.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine Triphosphate; Aminobenzoates; Animals; Aristolochic Acids; Benzoquinones; Bucladesine; Calmodulin; Cell Membrane; Chlorobenzoates; Cinnamates; Enzyme Inhibitors; Gastric Acid; Gastric Mucosa; H(+)-K(+)-Exchanging ATPase; Hydrogen-Ion Concentration; In Vitro Techniques; Mitochondria; Myosin-Light-Chain Kinase; Neomycin; ortho-Aminobenzoates; Parietal Cells, Gastric; Phenanthrenes; Phospholipases A; Phospholipases A2; Phosphoprotein Phosphatases; Protein Kinase Inhibitors; Protons; Rabbits; Signal Transduction; Type C Phospholipases | 1999 |
Sesquiterpene esters of aristolochic acid from the root and stem of Aristolochia heterophylla.
Topics: Animals; Antineoplastic Agents, Phytogenic; Aristolochic Acids; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Liver Neoplasms, Experimental; Magnetic Resonance Spectroscopy; Molecular Conformation; Phenanthrenes; Plant Roots; Plant Stems; Sesquiterpenes; Tumor Cells, Cultured | 1999 |
[Aristolochic acids in herbal medicines].
Topics: Antineoplastic Agents; Aristolochic Acids; Drugs, Chinese Herbal; Female; Humans; Nephritis, Interstitial; Phenanthrenes; Plants, Medicinal | 1998 |
Quantitative analysis of aristolochic acids, toxic compounds, contained in some medicinal plants.
Topics: Aristolochic Acids; Carcinogens; Chromatography, High Pressure Liquid; Magnoliopsida; Phenanthrenes; Plants, Medicinal | 1999 |
Interleukin-1 stimulates Jun N-terminal/stress-activated protein kinase by an arachidonate-dependent mechanism in mesangial cells.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Aristolochic Acids; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Dinoprostone; Enzyme Activation; Enzyme Inhibitors; Fatty Acids, Unsaturated; Glomerular Mesangium; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Leukotrienes; Lipid Peroxides; Mitogen-Activated Protein Kinases; Nephritis; Phenanthrenes; Phosphodiesterase Inhibitors; Phospholipases A; Phospholipases A2; Rats; Signal Transduction; Stearic Acids; Tritium; Vasoconstrictor Agents | 1999 |
Urothelial lesions in Chinese-herb nephropathy.
Topics: Adult; Aristolochic Acids; Carcinogens; Carcinoma in Situ; Carcinoma, Transitional Cell; Drugs, Chinese Herbal; Female; Humans; Kidney; Kidney Diseases; Kidney Neoplasms; Middle Aged; Phenanthrenes; Tumor Suppressor Protein p53; Ureter; Ureteral Neoplasms | 1999 |
On a nephrotoxic and carcinogenic slimming regimen.
Topics: Analgesics; Animals; Aristolochic Acids; Balkan Nephropathy; Carcinogens; Carcinoma, Transitional Cell; Drugs, Chinese Herbal; Humans; Kidney Neoplasms; Phenacetin; Phenanthrenes; Weight Loss | 1999 |
Pentoxifylline-stimulated capacitation and acrosome reaction in hamster spermatozoa: involvement of intracellular signalling molecules.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acrosome Reaction; Animals; Aristolochic Acids; Cricetinae; Cyclic AMP; Enzyme Inhibitors; Kinetics; Male; Mesocricetus; Models, Biological; Pentoxifylline; Phenanthrenes; Phospholipases A; Phospholipases A2; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; Sperm Capacitation; Sperm Motility; Spermatozoa; Staurosporine; Tyrphostins | 1999 |
[On Chinese herbs neuropathy].
Topics: Aristolochic Acids; Drugs, Chinese Herbal; Humans; Kidney Diseases; Phenanthrenes; Terminology as Topic | 1999 |
Formation of reactive oxygen species by the contracting diaphragm is PLA(2) dependent.
Topics: Animals; Arachidonic Acids; Aristolochic Acids; Diaphragm; Electric Stimulation; Enzyme Activation; Enzyme Inhibitors; Ethidium; Fluorescence; Free Radicals; Kinetics; Male; Muscle Contraction; Naphthalenes; Phenanthrenes; Phospholipases A; Pyrones; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxides; Terpenes | 1999 |
Aristolactam I a metabolite of aristolochic acid I upon activation forms an adduct found in DNA of patients with Chinese herbs nephropathy.
Topics: Animals; Aristolochic Acids; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dioxoles; DNA; DNA Adducts; Drugs, Chinese Herbal; Fibrosis; Horseradish Peroxidase; Humans; Hydrogen Peroxide; Indoles; Kidney Diseases; Male; Phenanthrenes; Rats; Rats, Sprague-Dawley; Ureter | 1999 |
Nephropathy caused by Chinese herbs in the UK.
Topics: Aristolochic Acids; Biopsy; Drugs, Chinese Herbal; Eczema; Female; Humans; Kidney; Kidney Failure, Chronic; Kidney Function Tests; Middle Aged; Phenanthrenes | 1999 |
Chinese-herb nephropathy.
Topics: Acute Kidney Injury; Aristolochic Acids; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Female; Humans; Male; Phenanthrenes | 1999 |
Chinese-herb nephropathy.
Topics: Acute Kidney Injury; Aristolochic Acids; Drug Contamination; Drugs, Chinese Herbal; Humans; Japan; Phenanthrenes; Quality Assurance, Health Care | 1999 |
AA-861-induced Ca(2+) mobilization in Madin Darby canine kidney cells.
Topics: Animals; Aristolochic Acids; Benzoquinones; Calcium; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cells, Cultured; Dogs; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Enzyme Inhibitors; Fluorometry; Inositol 1,4,5-Trisphosphate; Kidney; Lipoxygenase Inhibitors; Lysosomes; Phenanthrenes; Phospholipases A; Thapsigargin; Time Factors; Uncoupling Agents | 1999 |
W-7 induces [Ca(2+)](i) increases in Madin-Darby canine kidney (MDCK) cells.
Topics: Animals; Aristolochic Acids; Calcium; Calcium Signaling; Calmodulin; Cells, Cultured; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Estrenes; Fluorescence; Fura-2; Hydrazones; Kidney; Phenanthrenes; Propranolol; Pyrrolidinones; Sulfonamides; Thapsigargin; Time Factors | 2000 |
Platelet activating factor acetylhydrolase activity in lamb lungs is up-regulated in the immediate newborn period.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Amino Acid Sequence; Animals; Animals, Newborn; Aristolochic Acids; Binding Sites; Cell Extracts; Enzyme Activation; Enzyme Induction; Kinetics; Lung; Molecular Sequence Data; Oxygen; Phenanthrenes; Phospholipases A; Platelet Activating Factor; RNA, Messenger; Sheep; Time Factors | 2000 |
Using polymerase arrest to detect DNA binding specificity of aristolochic acid in the mouse H-ras gene.
Topics: Adenine; Animals; Aristolochic Acids; Base Composition; Carcinogens; Codon; Deoxyadenosines; Deoxyguanosine; DNA Adducts; DNA Damage; DNA Replication; DNA-Directed DNA Polymerase; DNA, Recombinant; Genes, ras; Guanine; Mice; Oligodeoxyribonucleotides; Phenanthrenes; Plasmids; Templates, Genetic | 2000 |
[Callus formation of Aristolochia tuberosa and determination of aristolochic acid of callus by HPLC].
Topics: Aristolochic Acids; Chromatography, High Pressure Liquid; Culture Techniques; Magnoliopsida; Phenanthrenes; Plants, Medicinal | 1997 |
Stimulation of Ca(2+)-dependent exocytosis of the sperm acrosome by cAMP acting downstream of phospholipase A2.
Topics: Acrosome; Acrosome Reaction; Analysis of Variance; Animals; Aristolochic Acids; Bucladesine; Caffeine; Calcimycin; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Enzyme Inhibitors; Ionophores; Isoquinolines; Lysophosphatidylcholines; Male; Phenanthrenes; Phospholipases A; Phospholipases A2; Protein Kinase Inhibitors; Sheep; Stimulation, Chemical; Sulfonamides | 2000 |
Effects of inhibitors of arachidonic acid turnover on the production of prostaglandins by the guinea-pig uterus.
Topics: 1-Acylglycerophosphocholine O-Acyltransferase; 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Aristolochic Acids; Culture Techniques; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Endometrium; Enzyme Inhibitors; Female; Guinea Pigs; Oxidoreductases; Phenanthrenes; Phospholipases A; Phospholipases A2; Prostaglandins; Thimerosal | 2000 |
Chinese herb nephropathy in Japan presents adult-onset Fanconi syndrome: could different components of aristolochic acids cause a different type of Chinese herb nephropathy?
Topics: Adult; Aristolochic Acids; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Fanconi Syndrome; Female; Humans; Japan; Male; Middle Aged; Phenanthrenes | 2000 |
[Renal failure after eczema treatment with Chinese herbal medicine].
Topics: Aristolochic Acids; Drugs, Chinese Herbal; Eczema; Female; Humans; Kidney Failure, Chronic; Middle Aged; Phenanthrenes | 2000 |
Urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi)
Topics: Anti-Obesity Agents; Aristolochic Acids; Carcinogens; DNA Adducts; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Female; Humans; Kidney; Kidney Failure, Chronic; Male; Middle Aged; Ochratoxins; Phenanthrenes; Prevalence; Risk Factors; Ureter; Urologic Neoplasms; Urothelium | 2000 |
Cancer and herbs.
Topics: Aristolochic Acids; Carcinogens; Dietary Supplements; Drugs, Chinese Herbal; Female; Humans; Kidney Failure, Chronic; Legislation, Drug; Phenanthrenes; United States; United States Food and Drug Administration; Urologic Neoplasms; Urothelium | 2000 |
Herbal hazard.
Topics: Aristolochic Acids; Carcinogens; Drug and Narcotic Control; Drugs, Chinese Herbal; Humans; Phenanthrenes; United States; United States Food and Drug Administration | 2000 |
The characteristic pattern of aminoaciduria in patients with aristolochic acid-induced Fanconi syndrome: could iminoaciduria be the hallmark of this syndrome?
Topics: Adult; Amino Acids; Aristolochic Acids; Fanconi Syndrome; Female; Humans; Imino Acids; Male; Phenanthrenes | 2000 |
Cytosolic phospholipase A2 is required for optimal ATP activation of BK channels in GH(3) cells.
Topics: Adenosine Triphosphate; Adenylyl Imidodiphosphate; Animals; Aristolochic Acids; Blotting, Western; Cell Line; Cell Membrane; Cytosol; Enzyme Inhibitors; Hydrolysis; Large-Conductance Calcium-Activated Potassium Channels; Oligonucleotides, Antisense; Patch-Clamp Techniques; Phenanthrenes; Phospholipases A; Phospholipases A2; Phosphorylation; Potassium Channels; Potassium Channels, Calcium-Activated; Protein Isoforms; Protein Kinase C; Rats | 2001 |
Characterization of ATP-sensitive potassium channels functionally expressed in pituitary GH3 cells.
Topics: 2,4-Dinitrophenol; Action Potentials; Adenoma; Adenosine Triphosphate; Animals; Aristolochic Acids; Calcium Chloride; Diazoxide; Disulfides; Enzyme Activation; Ion Transport; Magnesium; Melitten; Nicorandil; Phenanthrenes; Phospholipases A; Phospholipases A2; Pituitary Gland, Anterior; Pituitary Neoplasms; Potassium; Potassium Channels; Pyridines; Rats; Sodium Cyanide; Tumor Cells, Cultured | 2000 |
Neutrophil-mediated biodegradation of medical implant materials.
Topics: Aristolochic Acids; Biocompatible Materials; Biodegradation, Environmental; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Humans; Neutrophils; Phenanthrenes; Phenylmethylsulfonyl Fluoride; Phospholipases A; Phospholipases A2; Polyurethanes; Prostheses and Implants; Quinacrine; Tetradecanoylphorbol Acetate | 2001 |
Reversible Fanconi syndrome after ingestion of a Chinese herbal 'remedy' containing aristolochic acid.
Topics: Aristolochic Acids; Bone and Bones; Drugs, Chinese Herbal; Fanconi Syndrome; Humans; Male; Muscular Diseases; Pain; Phenanthrenes | 2001 |
Sequence-specific detection of aristolochic acid-DNA adducts in the human p53 gene by terminal transferase-dependent PCR.
Topics: Aristolochic Acids; Breast Neoplasms; Carcinogens; Chromosome Mapping; DNA; DNA Adducts; DNA Nucleotidylexotransferase; DNA, Neoplasm; Exons; Genes, p53; Humans; Mutation; Phenanthrenes; Polymerase Chain Reaction; Substrate Specificity; Tumor Cells, Cultured; Urologic Neoplasms; Urothelium | 2001 |
Novel effects of 5,8,11-eicosatriynoic acid, a lipoxygenase inhibitor, on Ca2+ mobilization in Madin Darby canine kidney cells.
Topics: Animals; Aristolochic Acids; Calcium; Calcium Signaling; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cells, Cultured; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fatty Acids, Unsaturated; Kidney; Phenanthrenes; Plant Extracts; Thapsigargin; Type C Phospholipases | 2001 |
Chinese herbs and urothelial carcinoma.
Topics: Acetazolamide; Anti-Obesity Agents; Aristolochic Acids; Drug Interactions; Drugs, Chinese Herbal; Fenfluramine; Humans; Phenanthrenes; Urologic Neoplasms; Urothelium | 2000 |
Chinese herbs and urothelial carcinoma.
Topics: Anti-Obesity Agents; Aristolochic Acids; Drugs, Chinese Herbal; Humans; Kidney Failure, Chronic; Phenanthrenes; Urologic Neoplasms; Urothelium | 2000 |
Pressurized liquid extraction of berberine and aristolochic acids in medicinal plants.
Topics: Aristolochic Acids; Berberine; Chromatography, High Pressure Liquid; Phenanthrenes; Plants, Medicinal; Reference Standards; Reproducibility of Results; Sensitivity and Specificity | 2000 |
Selective dopaminergic vulnerability: 3,4-dihydroxyphenylacetaldehyde targets mitochondria.
Topics: 3,4-Dihydroxyphenylacetic Acid; 4-Aminobenzoic Acid; Aminobenzoates; Animals; Aristolochic Acids; Cell Death; Cell Differentiation; Cyclosporine; Dopamine; Dopamine Antagonists; Enzyme Inhibitors; Ion Channels; Male; Membrane Proteins; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Nerve Growth Factor; para-Aminobenzoates; Parkinson Disease; PC12 Cells; Phenanthrenes; Rats; Rats, Inbred F344; Respiration; Rotenone; Trifluoperazine; Uncoupling Agents | 2001 |
A peripheral mechanism for behavioral adaptation to specific "bitter" taste stimuli in an insect.
Topics: Adaptation, Physiological; Animals; Aristolochic Acids; Caffeine; Chemoreceptor Cells; Drug Tolerance; Feeding Behavior; Food, Formulated; Larva; Manduca; Phenanthrenes; Stimulation, Chemical; Taste | 2001 |
Outbreak of Chinese herb nephropathy in Japan: are there any differences from Belgium?
Topics: Aristolochic Acids; Asian People; Belgium; Calcitriol; Disease Outbreaks; Drugs, Chinese Herbal; Fanconi Syndrome; Female; Humans; Japan; Kidney; Kidney Diseases; Male; Phenanthrenes; Prednisolone; Renal Dialysis; Sodium Bicarbonate; White People | 2001 |
Chronic aristolochic acid toxicity in rabbits: a model of Chinese herbs nephropathy?
Topics: Animals; Aristolochic Acids; Disease Models, Animal; Drugs, Chinese Herbal; Enzyme Inhibitors; Female; Fibrosis; Kidney; Nephritis, Interstitial; Organ Size; Phenanthrenes; Rabbits; Stomach | 2001 |
From the Food and Drug Administration.
Topics: AIDS-Related Opportunistic Infections; Antiviral Agents; Aristolochic Acids; Arrhythmias, Cardiac; Cytomegalovirus Retinitis; Dietary Supplements; Drug Labeling; Ganciclovir; Humans; Kidney Diseases; Methadyl Acetate; Narcotics; Opioid-Related Disorders; Phenanthrenes; Phytotherapy; Prodrugs; United States; United States Food and Drug Administration; Valganciclovir | 2001 |
Focus on "contrasting effects of cPLA2 on epithelial Na+ transport".
Topics: Animals; Aristolochic Acids; Enzyme Inhibitors; Epithelial Cells; Epithelial Sodium Channels; Ion Transport; Phenanthrenes; Phospholipases A; Sodium; Sodium Channels | 2001 |
Contrasting effects of cPLA2 on epithelial Na+ transport.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Aristolochic Acids; Cell Line; Cell Membrane Permeability; Dinoprostone; Enzyme Inhibitors; Epithelial Sodium Channels; Fatty Acids, Unsaturated; Ion Transport; Kidney; Patch-Clamp Techniques; Phenanthrenes; Phospholipases A; Phospholipases A2; Sodium; Sodium Channels; Xenopus laevis | 2001 |
Analyses of DNA adducts formed by ochratoxin A and aristolochic acid in patients with Chinese herbs nephropathy.
Topics: Adult; Animals; Anti-Obesity Agents; Aristolochic Acids; Balkan Nephropathy; Belgium; DNA Adducts; Drugs, Chinese Herbal; Female; Humans; Male; Middle Aged; Mycotoxins; Ochratoxins; Phenanthrenes; Rats; Rats, Wistar; Renal Insufficiency | 2001 |
Role of prostaglandins in the suppression of apoptosis in hen granulosa cells by transforming growth factor alpha.
Topics: Alprostadil; Animals; Apoptosis; Arachidonic Acid; Arachidonic Acids; Aristolochic Acids; Cells, Cultured; Chickens; Chromatin; Culture Media, Serum-Free; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; DNA Fragmentation; Enzyme Inhibitors; Female; Granulosa Cells; Ibuprofen; Nitrobenzenes; Phenanthrenes; Phospholipases A; Prostaglandins; Prostaglandins E; Prostaglandins F; Sulfonamides; Transforming Growth Factor alpha | 2001 |
Determination of aristolochic acids in medicinal plants (Chinese) prepared medicine using capillary zone electrophoresis.
Topics: Aristolochic Acids; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Electrophoresis, Capillary; Medicine, Chinese Traditional; Phenanthrenes; Plants, Medicinal | 2001 |
Human enzymes involved in the metabolic activation of carcinogenic aristolochic acids: evidence for reductive activation by cytochromes P450 1A1 and 1A2.
Topics: Animals; Aristolochic Acids; Carcinogens; Catalysis; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; DNA Adducts; Gene Expression Regulation; Humans; Male; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Phenanthrenes; Phosphorus Radioisotopes; Rats; Rats, Wistar; Swine | 2001 |
Evidence for reductive activation of carcinogenic aristolochic acids by prostaglandin H synthase -- (32)P-postlabeling analysis of DNA adduct formation.
Topics: Animals; Aristolochic Acids; Biotransformation; Carcinogens; Cyclooxygenase Inhibitors; DNA Adducts; In Vitro Techniques; Indomethacin; Male; Oxidation-Reduction; Phenanthrenes; Phosphorus Radioisotopes; Prostaglandin-Endoperoxide Synthases; Seminal Vesicles; Sheep | 2001 |
Calcium-independent phospholipase A(2) is required for human monocyte chemotaxis to monocyte chemoattractant protein 1.
Topics: Aminobenzoates; Arachidonic Acid; Arachidonic Acids; Aristolochic Acids; Chemokine CCL2; Chemotaxis, Leukocyte; Chlorobenzoates; Cinnamates; Enzyme Inhibitors; Fatty Acids; Group IV Phospholipases A2; Group VI Phospholipases A2; Humans; Inflammation; Lysophospholipids; Monocytes; Naphthalenes; Oligodeoxyribonucleotides, Antisense; ortho-Aminobenzoates; Phenanthrenes; Phospholipases A; Pyrones; Signal Transduction | 2001 |
The inhibition of platelet aggregation and blood coagulation by Micropechis ikaheka venom.
Topics: Anticoagulants; Aristolochic Acids; Bleeding Time; Blood Coagulation; Cell Adhesion; Cells, Cultured; Collagen; Dose-Response Relationship, Drug; Elapid Venoms; Electrophoresis, Gel, Two-Dimensional; Endothelium, Vascular; Fibronectins; Humans; Mass Spectrometry; Phenanthrenes; Phospholipases A; Phospholipases A2; Platelet Aggregation; Proteins; Thromboplastin; Vitronectin | 2001 |
Aristolochic acid impedes endocytosis and induces DNA adducts in proximal tubule cells.
Topics: Absorption; Animals; Aristolochic Acids; beta 2-Microglobulin; Cadmium Chloride; Cell Survival; Cells, Cultured; DNA Adducts; Endocytosis; Kidney Tubules, Proximal; Low Density Lipoprotein Receptor-Related Protein-2; Opossums; Phenanthrenes; Proteins; Receptors, Cell Surface; Serum Albumin; Tissue Distribution | 2001 |
Selective adaptation to noxious foods by a herbivorous insect.
Topics: Adaptation, Physiological; Animals; Aristolochic Acids; Behavior, Animal; Benzyl Alcohols; Food; Glucosides; Manduca; Phenanthrenes; Taste | 2001 |
Is "Chinese herbs nephropathy" a prejudicial term?
Topics: Aristolochic Acids; Drugs, Chinese Herbal; Humans; Kidney; Phenanthrenes; Renal Insufficiency; Terminology as Topic | 2001 |
Aristolochic acid nephropathy in a Chinese patient: time to abandon the term "Chinese herbs nephropathy"?
Topics: Aristolochic Acids; DNA Adducts; Drugs, Chinese Herbal; Female; Humans; Kidney; Middle Aged; Phenanthrenes; Renal Insufficiency; Terminology as Topic | 2001 |
Urothelial malignant disease and Chinese herbal nephropathy.
Topics: Aristolochic Acids; Carcinogens; Carcinoma, Transitional Cell; Drugs, Chinese Herbal; Female; Humans; Kidney Failure, Chronic; Middle Aged; Phenanthrenes; Ureteral Neoplasms | 2001 |
[Establishment of model of aristolochic acid-induced chronic renal interstitial fibrosis in rats].
Topics: Animals; Aristolochic Acids; Blood Urea Nitrogen; Body Weight; Carcinogens; Chronic Disease; Creatine; Disease Models, Animal; Female; Fibrosis; Kidney Tubules, Proximal; Nephritis, Interstitial; Phenanthrenes; Rats; Rats, Wistar | 2001 |
[The clinical and pathological manifestations of aristolochic acid nephropathy--the report of 58 cases].
Topics: Adult; Aristolochic Acids; Carcinogens; Chronic Disease; Drugs, Chinese Herbal; Female; Humans; Kidney Tubular Necrosis, Acute; Male; Middle Aged; Nephritis, Interstitial; Phenanthrenes | 2001 |
Aristolochic acid I-induced apoptosis in LLC-PK1 cells and amelioration of the apoptotic damage by calcium antagonist.
Topics: Animals; Apoptosis; Aristolochic Acids; Calcium Channel Blockers; Dihydropyridines; LLC-PK1 Cells; Phenanthrenes; Swine | 2000 |
Aristolochic acids induce chronic renal failure with interstitial fibrosis in salt-depleted rats.
Topics: Animals; Aristolochic Acids; Body Weight; Carcinoma, Transitional Cell; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Fibrosis; Injections, Subcutaneous; Kidney; Kidney Failure, Chronic; Kidney Tubules; Male; Pelvic Neoplasms; Phenanthrenes; Rats; Rats, Wistar; Reference Values; Sarcoma; Sodium Chloride; Survival Analysis | 2002 |
High-performance liquid chromatographic determination for aristolochic acid in medicinal plants and slimming products.
Topics: Appetite Depressants; Aristolochic Acids; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Phenanthrenes; Plants, Medicinal; Sensitivity and Specificity | 2002 |
Inhibition by R(+) or S(-) pramipexole of caspase activation and cell death induced by methylpyridinium ion or beta amyloid peptide in SH-SY5Y neuroblastoma.
Topics: 1-Methyl-4-phenylpyridinium; Alzheimer Disease; Amyloid beta-Peptides; Anti-Bacterial Agents; Aristolochic Acids; Benzothiazoles; Bongkrekic Acid; Brain; Caspase Inhibitors; Caspases; Cell Death; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radical Scavengers; Humans; Neuroblastoma; Neurodegenerative Diseases; Neurons; Parkinson Disease; Peptide Fragments; Phenanthrenes; Pramipexole; Thiazoles; Tumor Cells, Cultured | 2002 |
When is "aristolochic acid nephropathy" more accurate than "Chinese herbs nephropathy"?
Topics: Aristolochic Acids; Drugs, Chinese Herbal; Humans; Kidney Diseases; Phenanthrenes; Terminology as Topic | 2002 |
Aristolochic acid as a causative factor in a case of Chinese herbal nephropathy.
Topics: Aristolochia; Aristolochic Acids; Bone Marrow; Drugs, Chinese Herbal; Humans; Male; Middle Aged; Nephritis, Interstitial; Phenanthrenes | 2002 |
Detecting aristolochic acids in herbal remedies by liquid chromatography/serial mass spectrometry.
Topics: Aristolochia; Aristolochic Acids; Carcinogens; Chromatography, Liquid; Herbal Medicine; Mass Spectrometry; Phenanthrenes; Plant Extracts; Plant Leaves; Reproducibility of Results; Sensitivity and Specificity | 2002 |
Aristolochic acid-induced Fanconi's syndrome and nephropathy presenting as hypokalemic paralysis.
Topics: Acute Kidney Injury; Aristolochic Acids; Drugs, Chinese Herbal; Fanconi Syndrome; Humans; Hypokalemia; Male; Middle Aged; Paralysis; Phenanthrenes | 2002 |
Chinese herbal nephropathy.
Topics: Aristolochic Acids; Carcinoma, Transitional Cell; Drugs, Chinese Herbal; Humans; Kidney Failure, Chronic; Kidney Neoplasms; Obesity; Phenanthrenes; Phytotherapy; Risk | 2002 |
[Renal interstitial fibrosis and urotelial carcinomas after ingestion of a Chinese herb (Aristolochia fangchi)].
Topics: Anti-Obesity Agents; Aristolochia; Aristolochic Acids; Atrophy; Biomarkers; Carcinogens; Carcinoma, Papillary; Carcinoma, Transitional Cell; DNA Adducts; DNA Damage; Drugs, Chinese Herbal; Female; Fibrosis; Humans; Kidney Neoplasms; Kidney Transplantation; Kidney Tubular Necrosis, Acute; Kidney Tubules, Proximal; Male; Neprilysin; Phenanthrenes; Phytotherapy; Plant Preparations; Postoperative Complications; Urinary Bladder Neoplasms | 2002 |
Mutagenicity of aristolochic acid in the lambda/lacZ transgenic mouse (MutaMouse).
Topics: Animals; Aristolochic Acids; Base Sequence; Gastric Mucosa; Kidney; Lac Operon; Male; Mice; Mice, Transgenic; Micronucleus Tests; Molecular Sequence Data; Mutagens; Mutation; Phenanthrenes; Stomach; Transcription Factors; Urinary Bladder; Viral Proteins | 2002 |
Carcinogenic aristolochic acids upon activation by DT-diaphorase form adducts found in DNA of patients with Chinese herbs nephropathy.
Topics: Aldehyde Oxidase; Aldehyde Oxidoreductases; Animals; Antineoplastic Agents; Aristolochic Acids; Carcinogens; Cell Nucleus; Chromatography, High Pressure Liquid; Cytosol; DNA; DNA Adducts; DNA, Complementary; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Enzyme Activation; Liver; Models, Chemical; Models, Molecular; NAD(P)H Dehydrogenase (Quinone); Nephritis; Phenanthrenes; Rats; Rats, Wistar; Thymus Gland; Time Factors; Xanthine Oxidase | 2002 |
Carcinogenic and nephrotoxic alkaloids aristolochic acids upon activation by NADPH : cytochrome P450 reductase form adducts found in DNA of patients with Chinese herbs nephropathy.
Topics: Animals; Aristolochic Acids; Carcinogens; Cattle; DNA; DNA Adducts; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Enzyme Activation; Kidney; Liver; Male; Microsomes, Liver; Models, Chemical; NADPH-Ferrihemoprotein Reductase; Phenanthrenes; Rats; Rats, Wistar; Time Factors | 2001 |
Contribution of different taste cells and signaling pathways to the discrimination of "bitter" taste stimuli by an insect.
Topics: Animals; Aristolochic Acids; Benzyl Alcohols; Caffeine; Chemoreceptor Cells; Discrimination, Psychological; Generalization, Psychological; Glucosides; Habituation, Psychophysiologic; Larva; Manduca; Phenanthrenes; Plant Extracts; Predictive Value of Tests; Signal Transduction; Stimulation, Chemical; Taste | 2002 |
Structural basis of phospholipase A2 inhibition for the synthesis of prostaglandins by the plant alkaloid aristolochic acid from a 1.7 A crystal structure.
Topics: Animals; Aristolochia; Aristolochic Acids; Binding, Competitive; Crystallization; Crystallography, X-Ray; Daboia; Enzyme Inhibitors; Models, Molecular; Phenanthrenes; Phospholipases A; Phospholipases A2; Prostaglandins; Protein Conformation; Structure-Activity Relationship; Viper Venoms | 2002 |
Is aristolochic acid a risk factor for Balkan endemic nephropathy-associated urothelial cancer?
Topics: Aged; Aristolochic Acids; Balkan Nephropathy; Carcinogens; DNA Adducts; Female; Humans; Middle Aged; Phenanthrenes; Risk Factors; Urologic Neoplasms; Urothelium | 2002 |
[On the antineoplastic activity of aristolochic acid].
Topics: Animals; Antineoplastic Agents; Aristolochic Acids; Neoplasms, Experimental; Phenanthrenes | 1961 |
ARISTOLOCHIC ACID INTOXICATION: A NEW TYPE OF IMPAIRMENT OF URINARY CONCENTRATING ABILITY.
Topics: Aristolochic Acids; Blood Chemical Analysis; Creatine; Creatinine; Electrolytes; Kidney Diseases; Kidney Tubules; Pathology; Phenanthrenes; Plant Poisoning; Rats; Research; Urea; Urine; Vasopressins | 1963 |
[ALTERATION OF INFECTION RESISTANCE BY ARISTOLOCHIC ACID].
Topics: Animals; Aristolochic Acids; Communicable Diseases; Drug Resistance; Drug Resistance, Microbial; Infections; Inflammation; Phagocytosis; Phenanthrenes; Plants, Medicinal; Rabbits; Rats; Research; Suppuration | 1963 |
[CLINICAL EXPERIENCE WITH ARISTOLOCHIC ACID IN EARLIER THERAPY-RESISTANT PROLONGED SUPPURATIONS].
Topics: Aristolochic Acids; Communicable Diseases; Drug Resistance; Drug Resistance, Microbial; Humans; Phenanthrenes; Plants, Medicinal; Suppuration; Wound Healing | 1963 |
ARISTOLOCHIC ACID (NSC-50413): PHASE I CLINICAL STUDY.
Topics: Antineoplastic Agents; Aristolochic Acids; Child; Drug Therapy; Neoplasms; Phenanthrenes; Research; Toxicology | 1964 |
[ON THE EFFICACY OF ARISTOLOCHIC ACID ON CHRONIC INFLAMMATORY TISSUE PROCESSES].
Topics: Aristolochic Acids; Arthritis; Drug Therapy; Humans; Osteomyelitis; Phenanthrenes; Pressure Ulcer; Stomatitis | 1964 |
PHOTOCHEMICAL SYNTHESIS OF PHENANTHRENES. SYNTHESIS OF ARISTOLOCHIC ACID.
Topics: Antineoplastic Agents; Aristolochic Acids; Chemistry, Pharmaceutical; Light; Pharmacy; Phenanthrenes; Research | 1965 |
New aristolochic acid, aristololactam and renal cytotoxic constituents from the stem and leaves of Aristolochia contorta.
Topics: Aristolochia; Aristolochic Acids; Cell Line; Humans; Kidney; Kidney Tubules, Proximal; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Conformation; Phenanthrenes; Plant Leaves; Plant Stems; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared | 2005 |
Cytotoxicity of phenanthrenes extracted from Aristolochia contorta in human proximal tubular epithelial cell line.
Topics: Aristolochia; Aristolochic Acids; Cell Line; Dose-Response Relationship, Drug; Epithelial Cells; Humans; Kidney Tubules, Proximal; L-Lactate Dehydrogenase; Microscopy, Electron; Phenanthrenes; Plant Extracts; Tetrazolium Salts | 2006 |
Metabolomic Responses of Human Hepatocytes to Emodin, Aristolochic Acid, and Triptolide: Chemicals Purified from Traditional Chinese Medicines.
Topics: Aristolochic Acids; Cell Line; Chromatography, Liquid; Diterpenes; Emodin; Epoxy Compounds; Hepatocytes; Humans; Mass Spectrometry; Medicine, Chinese Traditional; Metabolomics; Phenanthrenes | 2015 |
[Application of ultra high performance liquid chromatography-mass spectrometry to metabolomics study of drug-induced hepatotoxicity].
Topics: Acetaminophen; Aristolochic Acids; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Diterpenes; Emodin; Epoxy Compounds; Hepatocytes; Humans; Mass Spectrometry; Metabolomics; Phenanthrenes | 2015 |
Constituents from the stems of Aristolochia manshuriensis.
Topics: Anti-HIV Agents; Aristolochia; Dopamine; Furans; Glucosides; Inhibitory Concentration 50; Molecular Structure; Naphthoquinones; Nuclear Magnetic Resonance, Biomolecular; Phenanthrenes; Plant Stems; Plants, Medicinal; Taiwan | 2003 |