arglabin and parthenolide

arglabin has been researched along with parthenolide* in 1 studies

Other Studies

1 other study(ies) available for arglabin and parthenolide

ArticleYear
Biomimetic semisynthesis of arglabin from parthenolide.
    The Journal of organic chemistry, 2012, Aug-17, Volume: 77, Issue:16

    The semisynthesis of arglabin, an anticancer drug in clinical application, is developed from abundant natural product parthenolide via three steps. Each step in this sequence is highly stereoselective, and the substrate-dependent stereoselectivity in the epoxidation step can be explained by computational calculations. The success of chemical semisynthesis of arglabin suggests that the biosynthesis of arglabin might proceed in a similar pathway.

    Topics: Antineoplastic Agents; Biomimetics; Humans; Models, Molecular; Sesquiterpenes; Sesquiterpenes, Guaiane; Stereoisomerism

2012