Compounds > arginyl-glycyl-aspartyl-phenylalanine

arginyl-glycyl-aspartyl-phenylalanine and 1-2-3-4-tetrahydroisoquinoline

arginyl-glycyl-aspartyl-phenylalanine has been researched along with 1-2-3-4-tetrahydroisoquinoline* in 1 studies

Other Studies

1 other study(ies) available for arginyl-glycyl-aspartyl-phenylalanine and 1-2-3-4-tetrahydroisoquinoline

Article	Year
Derivatives of tetrahydroisoquinoline: synthesis and initial evaluation of novel non-peptide antagonists of the alpha(IIb)beta(3)-integrin. Bioorganic & medicinal chemistry letters, 2010, Aug-01, Volume: 20, Issue:15 The novel RGDF mimetics were synthesized with the use of 4-(1,2,3,4-tetrahydroisoquinoline-7-yl)amino-4-oxobutyric or 5-(1,2,3,4-tetrahydroisoquinoline-7-yl)amino-5-oxopentanoic acids as a surrogate of Arg-Gly motif. The synthesized compounds have demonstrated a high potency to inhibit platelet aggregation in vitro and to block FITC-Fg binding to alpha(IIb)beta(3) on washed human platelets. Topics: Fibrinogen; Fluorescein-5-isothiocyanate; Humans; Oligopeptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Tetrahydroisoquinolines	2010

Article

Year

Derivatives of tetrahydroisoquinoline: synthesis and initial evaluation of novel non-peptide antagonists of the alpha(IIb)beta(3)-integrin.

Bioorganic & medicinal chemistry letters, 2010, Aug-01, Volume: 20, Issue:15

The novel RGDF mimetics were synthesized with the use of 4-(1,2,3,4-tetrahydroisoquinoline-7-yl)amino-4-oxobutyric or 5-(1,2,3,4-tetrahydroisoquinoline-7-yl)amino-5-oxopentanoic acids as a surrogate of Arg-Gly motif. The synthesized compounds have demonstrated a high potency to inhibit platelet aggregation in vitro and to block FITC-Fg binding to alpha(IIb)beta(3) on washed human platelets.

Topics: Fibrinogen; Fluorescein-5-isothiocyanate; Humans; Oligopeptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Tetrahydroisoquinolines

2010