arginine has been researched along with thromboplastin in 84 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (19.05) | 18.7374 |
| 1990's | 20 (23.81) | 18.2507 |
| 2000's | 34 (40.48) | 29.6817 |
| 2010's | 14 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mann, KG; Nesheim, ME; Taswell, JB | 1 |
| Fleming, PB; Hughes, HN; Roberts, PS | 1 |
| Foster, DC; Kazama, Y; Kisiel, W | 1 |
| Maki, SL; Rapaport, SI; Warn-Cramer, BJ | 1 |
| Bertina, RM; Cupers, R; Mannucci, PM; Poort, SR; Reinalda-Poot, HH; Reitsma, PH; van der Linden, IK | 1 |
| Hijikata-Okunomiya, A; Okamoto, S; Wanaka, K | 1 |
| Hijikata-Okunomiya, A | 1 |
| Maki, SL; Rao, LV; Rapaport, SI; Warn-Cramer, BJ | 1 |
| Hara, H; Kikumoto, R; Okamoto, S; Tamao, Y | 1 |
| Loh, KW; Ong, TC | 1 |
| Church, WR; Krishnaswamy, S; Mann, KG; Nesheim, ME | 1 |
| Brain, MC; Hatton, MW; Pineo, GF; Regoeczi, E | 1 |
| Brecher, AS; Burkholder, DE; Burkholder, JS; Howe, WF | 1 |
| Fleming, PB; Roberts, PS | 1 |
| Giglio, JR; Rossi, A | 1 |
| Movat, HZ; Ozge-Anwar, AH; Soltay, MJ | 1 |
| Adams, RW; Elmore, DT | 1 |
| Glueck, HI; Wachman, J | 1 |
| Alkjaersig, N; Fletcher, AP; Sherry, S | 1 |
| Bastida, E; Escolar, G; Jamieson, GA; Ordinas, A | 1 |
| Ruf, W | 1 |
| Emi, N; Kojima, T; Matsushita, T; Saito, H; Takahashi, I | 1 |
| Blajchman, MA; Clarke, BJ; Sridhara, S | 1 |
| Lentz, BR; Pei, G; Powers, DD | 1 |
| Kario, K; Kodama, K; Koide, M; Matsuo, T | 1 |
| Prasa, D; Stürzebecher, J; Svendsen, L | 1 |
| Berry, CN; Charles, MC; Ferrari, P; Girard, D; Girardot, C; Lechaire, I; Lunven, C; O'Brien, DP | 1 |
| Banner, DW; Johnson, DJ; Kemball-Cook, G; McVey, JH; Takamiya, O; Tuddenham, EG | 1 |
| Esmon, CT; Esmon, NL; Kurosawa, S; Mather, T; Regan, L; Rezaie, AR; Safa, O; Smirnov, MD; Stearns-Kurosawa, DJ | 1 |
| Dahlbäck, B; Kaufman, RJ; Thorelli, E | 1 |
| Asseman, P; Bauters, C; Corseaux, D; Ezekowitz, MD; Jude, B; Le Tourneau, T; Mc Fadden, EP; Meurice, T; Six, I | 1 |
| Berry, CN; Gandossi, E; Gauffeny, C; Lunven, C; Roome, NO | 1 |
| Dickinson, CD; Edgington, TS; Olson, A; Rao, SM; Ruf, W; Shobe, J | 1 |
| Becker, JC; Hursting, MJ; Joffrion, JL; Knappenberger, GD; Schwarz, RP; Zehnder, JL | 1 |
| Facey, SL; Hertzberg, MS; Hogg, PJ | 1 |
| Gunn, AC; Marlowe, CK; Scarborough, RM; Sinha, U | 1 |
| Gebbink, MF; Marx, PF; Meijers, JC; Reijerkerk, A; Tiekstra, MJ; van Rossum, AG; Wagenaar, GT | 1 |
| Loscalzo, J; Yang, Y | 1 |
| Berry, CN; Girard, D; Lecoffre, C; Lochot, S; Visconte, C | 1 |
| Bordet, R; Corseaux, D; Jude, B; Lund, N; Pu, Q; Robin, E; Vallet, B; Wiel, E | 1 |
| Bachetti, T | 1 |
| DiCicco, RA; Hursting, MJ; Jorkasky, DK; Montague, T; Sheth, SB | 1 |
| Levi, M; Moons, AH; Peters, RJ | 1 |
| Adachi, Y; Gabazza, EC; Hayashi, T; Ido, M; Suzuki, K | 1 |
| Egashira, K; Katoh, M; Kubo-Inoue, M; Ohtani, K; Shimokawa, H; Takemoto, M; Takeshita, A; Usui, M | 1 |
| Manithody, C; Rezaie, AR; Yang, L | 2 |
| Akhavan, S; De Cristofaro, R; Landolfi, R; Lavoretano, S; Mannucci, PM; Peyvandi, F | 1 |
| Nagashima, H | 1 |
| Brufatto, N; Nesheim, ME | 1 |
| Eigenbrot, C; Lazarus, RA; Maun, HR | 1 |
| ARSCOTT, PM; KOPPEL, JL; OLWIN, JH | 1 |
| Berne, C; Felldin, M; Foss, A; Källen, R; Korsgren, O; Moberg, L; Nilsson, B; Olsson, A; Salmela, K; Tibell, A; Tufveson, G | 1 |
| Kittur, FS; Manithody, C; Morrissey, JH; Rezaie, AR | 1 |
| Fernández, JA; Griffin, JH; Mesters, RM; Yegneswaran, S | 1 |
| Krishnaswamy, S; Orcutt, SJ | 1 |
| Carlsson, K; Carlsson, U; Hammarström, P; Herland, A; Persson, E; Svensson, M; Wiréhn, J | 1 |
| Abdel-Meguid, SS; Babine, RE; Jin, L; Navaneetham, D; Pandey, P; Strickler, JE; Walsh, PN | 1 |
| Craven, S; Dewar, L; Greinacher, A; Ofosu, FA; Sheppard, JA; Warkentin, TE | 1 |
| Stief, TW | 1 |
| Renz, H; Stief, TW; Wieczerzak, A | 2 |
| Chen, FP; Jia, SJ; Jiang, DJ; Li, YJ; Song, K; Wang, GP; Xin, HY | 1 |
| Gale, AJ; Griffin, JH; Pellequer, JL; Xu, X; Yegneswaran, S | 1 |
| Curvers, J; Keuren, JF; Magdeleyns, EJ | 1 |
| Bukys, MA; Kalafatis, M; Kim, PY; Nesheim, ME; Orban, T | 1 |
| Kamath, P; Krishnaswamy, S | 1 |
| Kirklin, JK; Nielsen, VG | 1 |
| Cao, Y; Jiang, DJ; Li, XH; Li, YJ; Luo, ZQ; Xin, HY | 1 |
| Asada, Y; Imamura, T; Kitamura, K; Matsuda, S; Matsumoto, T; Moriguchi-Goto, S; Shima, M; Sugita, C; Sumi, T; Takahashi, M; Yamashita, A | 1 |
| Bradford, HN; Krishnaswamy, S; Micucci, JA | 1 |
| Jiang, X; Wong, PC | 1 |
| George, JF; Khan, ES; Kirklin, JK; Nielsen, VG | 1 |
| Berti de Marinis, G; Bonamigo, E; Girolami, A; Sartori, R; Vettore, S | 1 |
| Haynes, LM; Maille, NM; Silveira, JR; Tracy, PB; Wood, JP | 1 |
| Chen, QQ; Chen, X; Guo, R; Hu, CP; Li, D | 1 |
| Nogami, K; Ogiwara, K; Shibata, M; Shima, M; Yada, K | 1 |
| Barhoover, MA; Kalafatis, M | 1 |
| Berti de Marinis, G; Bonamigo, E; Girolami, A; Vettore, S | 1 |
| Akita, N; Asanuma, K; Asanuma, Y; Hayashi, T; Matsumine, A; Okamoto, T; Sudo, A; Uchida, A; Wakabayashi, H; Yoshikawa, T | 1 |
| Asada, Y; Harada, A; Hattori, K; Inoue, O; Iwakiri, T; Kitazawa, T; Matsuda, S; Matsumoto, T; Matsuura, Y; Okuyama, N; Shima, M; Sugita, C; Yamashita, A | 1 |
| Boyle, ME; Fisher, S; Ishimoto, J; Kiser, TH; Lind, SE; Trujillo, TC | 1 |
| Akita, N; Asanuma, K; Asanuma, Y; Hasegawa, M; Hayashi, T; Nishimura, A; Oi, T; Okamoto, T; Sudo, A; Yoshida, K; Yoshikawa, T | 1 |
| Ben-Omran, T; Blom, HJ; Dewik, AN; Gallego-Villar, L; Häberle, J; Hannibal, L; Kruger, WD; Nasrallah, GK; Thöny, B | 1 |
2 review(s) available for arginine and thromboplastin
| Article | Year |
|---|---|
Tissue factor and coronary artery disease.
Topics: Acute Disease; Angioplasty, Balloon, Coronary; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Anticoagulants; Arginine; Aspirin; Coronary Artery Disease; Coronary Thrombosis; Cyclosporine; Endothelium, Vascular; Factor VIIa; Heparin, Low-Molecular-Weight; Hirudin Therapy; Humans; Hypolipidemic Agents; Leukocytes, Mononuclear; Muscle, Smooth, Vascular; Recombinant Proteins; Thrombin; Thromboplastin | 2002 |
Cysteamine revisited: repair of arginine to cysteine mutations.
Topics: Animals; Apolipoprotein E3; Arginine; Argininosuccinate Lyase; Cystathionine beta-Synthase; Cysteamine; Cysteine; Cystinosis; Homeostasis; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Mutation; Mutation, Missense; Oxidation-Reduction; Sulfhydryl Compounds; Thromboplastin | 2017 |
2 trial(s) available for arginine and thromboplastin
| Article | Year |
|---|---|
Thrombin inhibition in the acute phase of ischaemic stroke using argatroban.
Topics: Aged; Antithrombins; Arginine; Brain Ischemia; Double-Blind Method; Female; Fibrin Fibrinogen Degradation Products; Glycerol; Humans; Male; Middle Aged; Partial Thromboplastin Time; Pipecolic Acids; Placebos; Reference Values; Sulfonamides; Thrombin; Thromboplastin | 1995 |
Interpreting the International Normalized Ratio (INR) in individuals receiving argatroban and warfarin.
Topics: Adult; Anticoagulants; Arginine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Factor X; Hemostatics; Humans; International Normalized Ratio; Male; Middle Aged; Partial Thromboplastin Time; Pipecolic Acids; Sulfonamides; Thromboplastin; Warfarin | 2001 |
80 other study(ies) available for arginine and thromboplastin
| Article | Year |
|---|---|
The contribution of bovine Factor V and Factor Va to the activity of prothrombinase.
Topics: Animals; Arginine; Blood Platelets; Calcium; Cattle; Dansyl Compounds; Enzyme Activation; Factor V; Factor X; Kinetics; Liposomes; Phosphatidylcholines; Phosphatidylserines; Protein Binding; Thromboplastin | 1979 |
The effects of hepes buffer on clotting tests, assay of factors V and VIII and on the hydrolysis of esters by thrombin and thrombokinase.
Topics: Animals; Arginine; Barbiturates; Blood Coagulation; Buffers; Cattle; Factor V; Factor VIII; HEPES; Humans; Hydrolysis; Imidazoles; Peptide Fragments; Piperazines; Thrombin; Thromboplastin; Tosylarginine Methyl Ester; Tromethamine | 1976 |
Evidence that an Arg79-->Gln substitution in human factor VII is not associated with a reduction in coagulant activity.
Topics: Animals; Arginine; Cells, Cultured; Cricetinae; Enzyme Activation; Factor VII; Factor X; Fibroblasts; Glutamine; Hemostasis; Humans; Kidney; Mesocricetus; Mutagenesis, Site-Directed; Oligopeptides; Recombinant Fusion Proteins; Thromboplastin | 1992 |
A sulfated rabbit endothelial cell glycoprotein that inhibits factor VIIa/tissue factor is functionally and immunologically identical to rabbit extrinsic pathway inhibitor (EPI).
Topics: Animals; Arginine; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Factor VII; Factor VIIa; Factor Xa; Glycoproteins; Immune Sera; In Vitro Techniques; Lipoproteins; Protein Binding; Rabbits; Thromboplastin | 1991 |
Mutations in hemophilia Bm occur at the Arg180-Val activation site or in the catalytic domain of factor IX.
Topics: Amino Acid Sequence; Antibodies, Monoclonal; Arginine; Binding Sites; Binding, Competitive; Chymotrypsin; DNA Restriction Enzymes; Factor IX; Factor VIIa; Factor X; Factor XIa; Hemophilia A; Humans; Molecular Sequence Data; Molecular Weight; Mutation; Protein Conformation; Prothrombin Time; Thromboplastin; Valine | 1990 |
Effect of a synthetic thrombin-inhibitor MD805 on the reaction between thrombin and plasma antithrombin-III.
Topics: Antithrombin III; Antithrombins; Arginine; Drug Interactions; Heparin; Humans; Peptide Hydrolases; Pipecolic Acids; Protein Binding; Sulfonamides; Thrombin; Thromboplastin | 1990 |
A new method for the determination of prothrombin in human plasma.
Topics: Arginine; Blood Coagulation Factors; Enzyme Activation; Heparin; Humans; Pipecolic Acids; Prothrombin; Sulfonamides; Thrombin; Thromboplastin | 1990 |
Modifications of extrinsic pathway inhibitor (EPI) and factor Xa that affect their ability to interact and to inhibit factor VIIa/tissue factor: evidence for a two-step model of inhibition.
Topics: Arginine; Binding, Competitive; Blood Coagulation; Factor Xa; Humans; Lipoproteins; Neoplasm Proteins; Serine Endopeptidases; Serine Proteinase Inhibitors; Thromboplastin | 1988 |
Effect of a synthetic thrombin inhibitor MCI-9038 on experimental models of disseminated intravascular coagulation in rabbits.
Topics: Animals; Antithrombin III; Antithrombins; Arginine; Disseminated Intravascular Coagulation; Dose-Response Relationship, Drug; Fibrinogen; Heparin; Male; Partial Thromboplastin Time; Pipecolic Acids; Platelet Count; Rabbits; Sulfonamides; Thromboplastin | 1987 |
Activation of prothrombin as measured by the conversion of Nalpha-benzoylarginine ethyl ester.
Topics: Animals; Arginine; Calcium; Cattle; Enzyme Activation; Factor V; Factor X; In Vitro Techniques; Kinetics; Phospholipids; Prothrombin; Thromboplastin | 1986 |
Activation of human prothrombin by human prothrombinase. Influence of factor Va on the reaction mechanism.
Topics: Arginine; Autoradiography; Dansyl Compounds; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Precursors; Factor V; Factor Va; Fluorescent Dyes; Humans; Kinetics; Prothrombin; Spectrometry, Fluorescence; Thrombin; Thromboplastin | 1987 |
The activation of coagulation by extracts of mucus: a possible pathway of intravascular coagulation accompanying adenocarcinomas.
Topics: Adenocarcinoma, Mucinous; Animals; Arginine; Blood Coagulation; Blood Coagulation Tests; Brain Chemistry; Bronchi; Chemical Precipitation; Disseminated Intravascular Coagulation; Esterases; Factor V Deficiency; Factor VII; Factor VII Deficiency; Factor X; Fibrinogen; Hemophilia B; Humans; Hypoprothrombinemias; Kaolin; Mucins; Mucus; Muramidase; Phospholipids; Prothrombin; Rabbits; Thromboplastin; Time Factors; Venoms | 1973 |
An evaluation of the utility of benzoyl-DL-arginine-beta-naphthyl-amide for the assay of thrombin activity in blood.
Topics: Animals; Arginine; Benzamides; Cattle; Coronary Disease; Coumarins; Factor VIII; Fibrinogen; Hirudins; Humans; Hydrolysis; Naphthalenes; Protein Binding; Prothrombin; Serum Albumin; Thrombin; Thromboplastin | 1974 |
The effects of salts and of ionic strength on the hydrolysis of TAME (p-toluenesulfonyl-L-arginine methyl ester) by thrombin and thrombokinase.
Topics: Animals; Arginine; Barium; Beryllium; Calcium Chloride; Cattle; Cesium; Chlorides; Choline; Humans; Hydrochloric Acid; Hydrolysis; Lithium; Magnesium; Osmolar Concentration; Potassium Chloride; Sodium Chloride; Strontium; Thrombin; Thromboplastin; Tosyl Compounds; Trypsin | 1972 |
[Activation of bovine prothrombin by trypsin. Identification of N-terminal residues].
Topics: Amino Acid Sequence; Amino Acids; Arginine; Chromatography, Ion Exchange; Citrates; Glutamates; Isoleucine; Lysine; Prothrombin; Sodium; Threonine; Thromboplastin; Trypsin | 1969 |
The kinin system of human plasma. V. The probable derivation of prekallikrein activator from activated Hageman factor (XIIa).
Topics: Adult; Arginine; Centrifugation, Density Gradient; Chromatography, Gel; Chromatography, Ion Exchange; Esterases; Factor XII; Humans; Isoelectric Focusing; Isoflurophate; Kaolin; Kinins; Middle Aged; Serine; Thromboplastin; Trypsin | 1971 |
The kinetics of hydrolysis of synthetic substrates by bovine factor Xa.
Topics: Animals; Arginine; Calcium; Cattle; Esters; Factor X; Kinetics; Lysine; Magnesium; Potassium; Sodium; Thrombin; Thromboplastin; Trypsin | 1971 |
A TAMe micromethod for the measurement of "esterase prothrombin".
Topics: Aminocaproates; Arginine; Esterases; Esters; Factor V; Factor VII; Factor X; Humans; Hydrogen-Ion Concentration; Liver; Methods; Microchemistry; Oxalates; Prothrombin; Prothrombin Time; Streptokinase; Thrombin; Thromboplastin; Toluene; Venoms; Warfarin | 1970 |
Comparative activity of thrombin on substituted arginine and lysine esters.
Topics: Animals; Arginine; Cattle; Chromatography; Esterases; In Vitro Techniques; Kinetics; Lysine; Thrombin; Thromboplastin | 1965 |
Tissue factor in microvesicles shed from U87MG human glioblastoma cells induces coagulation, platelet aggregation, and thrombogenesis.
Topics: Antibodies; Arginine; Blood Coagulation; Cell Line; Centrifugation, Density Gradient; Dansyl Compounds; Glioma; Humans; Neoplastic Stem Cells; Perfusion; Platelet Aggregation; Thromboplastin; Thrombosis | 1984 |
Factor VIIa residue Arg290 is required for efficient activation of the macromolecular substrate factor X.
Topics: Amides; Arginine; Factor VIIa; Factor X; Factor Xa; Humans; Mutagenesis, Site-Directed; Proteins; Recombinant Proteins; Structure-Activity Relationship; Substrate Specificity; Thromboplastin | 1994 |
Impaired human tissue factor-mediated activity in blood clotting factor VIINagoya (Arg304-->Trp). Evidence that a region in the catalytic domain of factor VII is important for the association with tissue factor.
Topics: Adult; Animals; Arginine; Base Sequence; Binding Sites; Blood Coagulation; Catalysis; Cattle; DNA Primers; Factor VII; Factor X; Humans; Hydrolysis; Male; Molecular Sequence Data; Mutation; Recombinant Proteins; Sequence Analysis, DNA; Thromboplastin; Tryptophan | 1994 |
Arginine-79 in the first epidermal growth factor domain of factor VII is essential for the interaction with tissue factor.
Topics: Arginine; Enzyme Activation; Factor VII; Factor X; Humans; Protein Binding; Recombinant Proteins; Thromboplastin | 1993 |
Specific contribution of different phospholipid surfaces to the activation of prothrombin by the fully assembled prothrombinase.
Topics: Arginine; Dansyl Compounds; Enzyme Activation; Factor Xa; Fluorescent Dyes; Humans; Kinetics; Phosphatidylglycerols; Phosphatidylserines; Phospholipids; Prothrombin; Structure-Activity Relationship; Surface Properties; Thermodynamics; Thromboplastin | 1993 |
Inhibition of thrombin generation in plasma by inhibitors of factor Xa.
Topics: Animals; Anticoagulants; Arginine; Arthropod Proteins; Cattle; Dipeptides; Factor Xa; Factor Xa Inhibitors; Fibrinolytic Agents; Hirudins; Humans; Intercellular Signaling Peptides and Proteins; Kinetics; Molecular Structure; Naphthalenes; Partial Thromboplastin Time; Peptides; Pipecolic Acids; Piperidines; Propionates; Rabbits; Recombinant Proteins; Serine Proteinase Inhibitors; Sulfonamides; Sulfones; Thrombin; Thromboplastin | 1997 |
Ecarin Clotting Time: a predictive coagulation assay for the antithrombotic activity of argatroban in the rat.
Topics: Animals; Antithrombins; Arginine; Arteriovenous Shunt, Surgical; Blood Coagulation Tests; Disease Models, Animal; Male; Pipecolic Acids; Rats; Rats, Inbred Strains; Reference Values; Sulfonamides; Thrombophlebitis; Thromboplastin; Thrombosis; Treatment Outcome | 1998 |
Coagulation factor VII Gln100 --> Arg. Amino acid substitution at the epidermal growth factor 2-protease domain interface results in severely reduced tissue factor binding and procoagulant function.
Topics: Amino Acid Substitution; Animals; Arginine; Blood Coagulation; Factor VII; Factor VII Deficiency; Glycine; Humans; Mutation; Recombinant Proteins; Thromboplastin | 1998 |
A chimeric protein C containing the prothrombin Gla domain exhibits increased anticoagulant activity and altered phospholipid specificity.
Topics: Amino Acid Sequence; Animals; Anticoagulants; Arginine; Cattle; DNA Primers; Factor Va; Humans; Kinetics; Liposomes; Models, Molecular; Molecular Sequence Data; Phosphatidylethanolamines; Protein C; Protein Conformation; Prothrombin; Recombinant Fusion Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Structure-Activity Relationship; Thromboplastin | 1998 |
Cleavage requirements of factor V in tissue-factor induced thrombin generation.
Topics: Arginine; Blood Coagulation Tests; Factor V; Humans; Mutagenesis, Site-Directed; Recombinant Proteins; Thrombin; Thromboplastin | 1998 |
Enhanced monocyte tissue factor response after experimental balloon angioplasty in hypercholesterolemic rabbit: inhibition with dietary L-arginine.
Topics: Angioplasty, Balloon; Animals; Arginine; Arteriosclerosis; Diet; Hypercholesterolemia; Leukocyte Count; Lipids; Male; Monocytes; Platelet Count; Rabbits; Thromboplastin | 1998 |
Platelet aggregation induced in vitro by rabbit plasma clot-associated thrombin, and its inhibition by thrombin inhibitors.
Topics: Animals; Antithrombin III; Arginine; Blood Coagulation; Blood Platelets; Heparin; Hirudins; Humans; Male; Microscopy, Electron, Scanning; Pipecolic Acids; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Recombinant Proteins; Sulfonamides; Thrombin; Thromboplastin | 1998 |
Importance of factor VIIa Gla-domain residue Arg-36 for recognition of the macromolecular substrate factor X Gla-domain.
Topics: 1-Carboxyglutamic Acid; Arginine; Endopeptidases; Factor VIIa; Factor X; Humans; Hydrolysis; Macromolecular Substances; Models, Molecular; Mutagenesis, Site-Directed; Peptide Fragments; Phospholipids; Protein Binding; Protein Structure, Tertiary; Software; Static Electricity; Substrate Specificity; Thromboplastin | 1999 |
The International Normalized Ratio during concurrent warfarin and argatroban anticoagulation: differential contributions of each agent and effects of the choice of thromboplastin used.
Topics: Anticoagulants; Arginine; Humans; International Normalized Ratio; Pipecolic Acids; Prothrombin Time; Sulfonamides; Thromboplastin; Warfarin | 1999 |
An Arg/Ser substitution in the second epidermal growth factor-like module of factor IX introduces an O-linked carbohydrate and markedly impairs activation by factor XIa and factor VIIa/Tissue factor and catalytic efficiency of factor IXa.
Topics: Amino Acid Substitution; Arginine; Blood Coagulation; Carbohydrates; Catalysis; Epidermal Growth Factor; Factor IX; Factor VIIa; Factor XIa; Humans; Point Mutation; Serine; Thromboplastin | 1999 |
Design, synthesis and structure-activity relationship of a series of arginine aldehyde factor Xa inhibitors. Part 1: structures based on the (D)-Arg-Gly-Arg tripeptide sequence.
Topics: Anticoagulants; Arginine; Drug Design; Factor Xa Inhibitors; Formic Acid Esters; Glycine; Oligopeptides; Structure-Activity Relationship; Substrate Specificity; Thromboplastin | 2000 |
Characterization of mouse thrombin-activatable fibrinolysis inhibitor.
Topics: Amino Acid Sequence; Animals; Antifibrinolytic Agents; Arginine; Blood Coagulation; Blotting, Western; Carboxypeptidase B2; Carboxypeptidases; Cloning, Molecular; DNA, Complementary; Fibrinolysis; Humans; In Situ Hybridization; Liver; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Recombinant Proteins; RNA, Messenger; Sequence Alignment; Sequence Analysis, DNA; Thromboplastin; Tissue Distribution | 2000 |
Regulation of tissue factor expression in human microvascular endothelial cells by nitric oxide.
Topics: Arginine; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Interleukin-1; Lipopolysaccharides; Microcirculation; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Thromboplastin | 2000 |
Activity of a sub-cutaneously administered novel mixed micellar formulation of argatroban in rat and rabbit models of venous thrombosis.
Topics: Animals; Anticoagulants; Antithrombins; Arginine; Arteriovenous Shunt, Surgical; Bleeding Time; Blood Coagulation Tests; Carotid Arteries; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Compounding; Drug Evaluation, Preclinical; Hemostatics; Heparin; Injections, Subcutaneous; Male; Micelles; Pipecolic Acids; Rabbits; Rats; Sulfonamides; Thromboplastin; Venous Thrombosis | 2000 |
Effect of L-arginine on endothelial injury and hemostasis in rabbit endotoxin shock.
Topics: Acetylcholine; Animals; Arginine; Blood Gas Analysis; Calcimycin; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Hemostasis; Ionophores; Lipopolysaccharides; Male; Monocytes; NG-Nitroarginine Methyl Ester; Nitroprusside; Phenylephrine; Rabbits; Shock, Septic; Thromboplastin; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents; Weight Loss | 2000 |
L-arginine and nitric oxide: an inseparable couple?
Topics: Arginine; Drug Interactions; Endotoxins; Enzyme Inhibitors; Humans; Interleukin-1; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; RNA, Messenger; Thromboplastin | 2001 |
Adenosine inhibits thrombin-induced expression of tissue factor on endothelial cells by a nitric oxide-mediated mechanism.
Topics: Adenosine; Adenosine Monophosphate; Arginine; Blotting, Northern; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Guanosine Monophosphate; Humans; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phosphodiesterase Inhibitors; Thrombin; Thromboplastin | 2002 |
Long-term inhibition of nitric oxide synthesis increases arterial thrombogenecity in rat carotid artery.
Topics: Administration, Oral; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antithrombins; Arginine; Blood Flow Velocity; Blood Pressure; Carotid Arteries; Carotid Artery Thrombosis; Enzyme Inhibitors; Gene Expression Regulation; Heart Rate; Imidazoles; Imidazolidines; Injections, Intravenous; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peptidyl-Dipeptidase A; Pipecolic Acids; Platelet Aggregation; Prothrombin Time; Rats; Rats, Inbred WKY; Sulfonamides; Thromboplastin; Transcription, Genetic | 2002 |
Role of basic residues of the autolysis loop in the catalytic function of factor Xa.
Topics: Antithrombins; Arginine; Catalysis; Cell Line; Factor Xa; Factor Xa Inhibitors; Humans; Kinetics; Lipoproteins; Lysine; Mutagenesis; Oligopeptides; Prothrombin; Thromboplastin | 2002 |
Molecular and functional characterization of a natural homozygous Arg67His mutation in the prothrombin gene of a patient with a severe procoagulant defect contrasting with a mild hemorrhagic phenotype.
Topics: Arginine; Blood Coagulation Disorders; Cell Line; Consanguinity; Factor Va; Factor Xa; Female; Fibrinopeptide A; Hemorrhagic Disorders; Heparin Cofactor II; Histidine; Homozygote; Humans; Hydrolysis; Infant; Mutagenesis, Site-Directed; Mutation; Protein C; Prothrombin; Receptor, PAR-1; Receptors, Thrombin; Thrombin; Thrombomodulin; Thromboplastin; Transfection | 2002 |
Studies on the different modes of action of the anticoagulant protease inhibitors DX-9065a and Argatroban. II. Effects on fibrinolysis.
Topics: Anticoagulants; Arginine; Blood Coagulation; Fibrinolysis; Humans; Kinetics; Naphthalenes; Pipecolic Acids; Propionates; Sulfonamides; Thrombomodulin; Thromboplastin | 2002 |
Analysis of the kinetics of prothrombin activation and evidence that two equilibrating forms of prothrombinase are involved in the process.
Topics: Arginine; Binding Sites; Binding, Competitive; DNA; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Precursors; Factor Va; Fluorescein; Humans; Kinetics; Models, Biological; Models, Theoretical; Mutagenesis, Site-Directed; Prothrombin; Recombinant Proteins; Thrombin; Thromboplastin; Time Factors | 2003 |
Engineering exosite peptides for complete inhibition of factor VIIa using a protease switch with substrate phage.
Topics: Amino Acid Sequence; Amino Acids; Anticoagulants; Arginine; Binding Sites; Crystallography, X-Ray; DNA; Dose-Response Relationship, Drug; Factor VIIa; Humans; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Models, Biological; Models, Molecular; Molecular Sequence Data; Peptide Library; Peptides; Protein Binding; Protein Structure, Tertiary; Prothrombin Time; Thromboplastin | 2003 |
Arginine esterase activity of blood thromboplastin.
Topics: Arginine; Carboxylic Ester Hydrolases; Esterases; Thromboplastin | 1959 |
Nicotinamide inhibits tissue factor expression in isolated human pancreatic islets: implications for clinical islet transplantation.
Topics: Arginine; Cells, Cultured; Chemokine CCL2; Cyclosporine; Enalapril; Gene Expression Regulation; Humans; Islets of Langerhans; Islets of Langerhans Transplantation; Kinetics; Niacinamide; Thromboplastin | 2003 |
The cofactor function of the N-terminal domain of tissue factor.
Topics: Allosteric Regulation; Arginine; Catalysis; Crystallography; Factor VIIa; Humans; Kinetics; Mutagenesis; Protein Structure, Tertiary; Structure-Activity Relationship; Thromboplastin | 2004 |
Prothrombin residues 473-487 contribute to factor Va binding in the prothrombinase complex.
Topics: Animals; Anisotropy; Arginine; Binding Sites; Blood Coagulation; Blotting, Western; Chymotrypsin; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Enzyme Precursors; Enzyme-Linked Immunosorbent Assay; Factor Va; Factor Xa; Fibrinogen; Fluorescein; Humans; Kinetics; Models, Molecular; Partial Thromboplastin Time; Peptides; Protein Binding; Prothrombin; Spectrometry, Fluorescence; Spectrophotometry; Thrombin; Thromboplastin; Viper Venoms | 2004 |
Binding of substrate in two conformations to human prothrombinase drives consecutive cleavage at two sites in prothrombin.
Topics: Amino Acid Sequence; Arginine; Binding Sites; Cell Line; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel; Humans; Kinetics; Mutagenesis, Insertional; Peptide Fragments; Protein Binding; Protein Conformation; Prothrombin; Recombinant Proteins; Structure-Activity Relationship; Substrate Specificity; Thromboplastin; Transfection | 2004 |
Activity, folding, misfolding, and aggregation in vitro of the naturally occurring human tissue factor mutant R200W.
Topics: Amyloid; Anilino Naphthalenesulfonates; Arginine; Benzothiazoles; Extracellular Space; Factor VIIa; Genetic Carrier Screening; Humans; Kinetics; Mutation; Nephelometry and Turbidimetry; Protein Binding; Protein Denaturation; Protein Folding; Spectrometry, Fluorescence; Substrate Specificity; Thiazoles; Thromboplastin; Tryptophan | 2005 |
Structural and mutational analyses of the molecular interactions between the catalytic domain of factor XIa and the Kunitz protease inhibitor domain of protease nexin 2.
Topics: Alanine; Alzheimer Disease; Arginine; Binding Sites; Carrier Proteins; Catalytic Domain; Crystallography, X-Ray; Disulfides; DNA Mutational Analysis; Dose-Response Relationship, Drug; Factor XIa; Humans; Inhibitory Concentration 50; Kinetics; Lysine; Models, Molecular; Models, Statistical; Mutation; Partial Thromboplastin Time; Phenylalanine; Plasmids; Point Mutation; Proline; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Recombinant Proteins; Serine; Serine Proteinase Inhibitors; Structure-Activity Relationship; Thromboplastin; Time Factors; Vesicular Transport Proteins | 2005 |
Differences in the clinically effective molar concentrations of four direct thrombin inhibitors explain their variable prothrombin time prolongation.
Topics: Animals; Anticoagulants; Arginine; Azetidines; Benzylamines; Blood Coagulation; Cattle; Dose-Response Relationship, Drug; Factor Xa; Factor Xa Inhibitors; Glycine; Hirudins; Humans; In Vitro Techniques; Partial Thromboplastin Time; Peptide Fragments; Pipecolic Acids; Prothrombin Time; Recombinant Proteins; Species Specificity; Sulfonamides; Thrombin; Thrombin Time; Thromboplastin | 2005 |
Thrombin generation by exposure of blood to endotoxin: a simple model to study disseminated intravascular coagulation.
Topics: Arginine; Blood; Blood Coagulation Tests; Cells, Cultured; Disseminated Intravascular Coagulation; Endotoxins; Humans; Lipopolysaccharide Receptors; Lipopolysaccharides; Models, Cardiovascular; Sepsis; Thrombin; Thromboplastin; Zymosan | 2006 |
Influence of coagulation factors on extrinsic thrombin generation.
Topics: Arginine; Blood Coagulation Factors; Blood Coagulation Tests; Calcium Chloride; Fibrinogen; Humans; Thrombin; Thromboplastin | 2007 |
Identification of a basic region on tissue factor that interacts with the first epidermal growth factor-like domain of factor X.
Topics: Alanine; Amino Acid Substitution; Arginine; Asparagine; Epidermal Growth Factor; Factor VIIa; Factor X; Humans; Lysine; Models, Molecular; Protein Structure, Tertiary; Thromboplastin | 2007 |
Regulation by DDAH/ADMA pathway of lipopolysaccharide-induced tissue factor expression in endothelial cells.
Topics: Amidohydrolases; Arginine; Base Sequence; Cells, Cultured; DNA Primers; Endothelial Cells; Gene Expression; Humans; Lipopolysaccharides; NF-kappa B; Reactive Oxygen Species; RNA, Messenger; Thromboplastin | 2007 |
Characterization of a factor Xa binding site on factor Va near the Arg-506 activated protein C cleavage site.
Topics: Amino Acid Substitution; Animals; Arginine; Binding Sites; Cattle; Crystallography, X-Ray; Factor Va; Factor Xa; Humans; Mutagenesis, Site-Directed; Peptide Fragments; Protein C; Prothrombin; Recombinant Proteins; Sequence Deletion; Thromboplastin | 2007 |
Factor Va, bound to microparticles released during platelet storage, is resistant to inactivation by activated protein C.
Topics: Arginine; Blood Coagulation; Blood Platelets; Blood Preservation; Electrophoresis, Polyacrylamide Gel; Factor Va; Hemostasis; Humans; Protein C; Thrombocytopenia; Thromboplastin | 2007 |
The interaction of fragment 1 of prothrombin with the membrane surface is a prerequisite for optimum expression of factor Va cofactor activity within prothrombinase.
Topics: Arginine; Binding Sites; Cell Membrane; Cells, Cultured; Endothelial Cells; Enzyme Inhibitors; Enzyme Precursors; Factor V; Factor Va; Factor Xa; Hirudins; Humans; Kinetics; Models, Molecular; Peptide Fragments; Protein Binding; Protein Conformation; Protein Precursors; Prothrombin; Thrombin; Thromboplastin | 2008 |
The extrinsic coagulation activity assay.
Topics: Arginine; Blood Coagulation Tests; Blood Preservation; Chromogenic Compounds; Humans; Nephelometry and Turbidimetry; Prothrombin Time; Reference Values; Temperature; Thrombin; Thromboplastin | 2008 |
Fate of membrane-bound reactants and products during the activation of human prothrombin by prothrombinase.
Topics: Animals; Arginine; Blood Proteins; Chickens; Genetic Variation; Humans; Kinetics; Models, Biological; Models, Chemical; Protein Binding; Protein Structure, Tertiary; Prothrombin; Surface Properties; Thermodynamics; Thromboplastin | 2008 |
Argatroban enhances fibrinolysis by differential inhibition of thrombin-mediated activation of thrombin activatable fibrinolysis inhibitor and factor XIII.
Topics: Anticoagulants; Arginine; Blood Coagulation; Carboxypeptidase B2; Factor XIII; Fibrinolysis; Heparin; Humans; Kaolin; Kinetics; Pipecolic Acids; Sulfonamides; Thrombelastography; Thrombin; Thromboplastin; Tissue Plasminogen Activator | 2008 |
Asymmetric dimethylarginine induces tissue factor expression in monocytes via NF-kappaB-dependent pathway: Role in acute coronary syndromes.
Topics: Acute Coronary Syndrome; Aged; Angina Pectoris; Arginine; Blood Coagulation; Case-Control Studies; Coagulants; Female; Humans; Male; Middle Aged; Monocytes; NF-kappa B; Nitric Oxide Synthase; Thromboplastin | 2009 |
Thrombin generation by intimal tissue factor contributes to thrombus formation on macrophage-rich neointima but not normal intima of hyperlipidemic rabbits.
Topics: Angioplasty, Balloon; Animals; Arginine; Femoral Artery; Humans; Hyperlipidemias; Lipoproteins; Macrophages; Male; Pipecolic Acids; Rabbits; Sulfonamides; Thrombin; Thromboplastin; Thrombosis; Tunica Intima | 2009 |
Regulated cleavage of prothrombin by prothrombinase: repositioning a cleavage site reveals the unique kinetic behavior of the action of prothrombinase on its compound substrate.
Topics: Amino Acid Sequence; Animals; Arginine; Catalytic Domain; Cell Line; Humans; Kinetics; Models, Molecular; Molecular Sequence Data; Mutant Proteins; Prothrombin; Substrate Specificity; Sus scrofa; Thromboplastin | 2010 |
Apixaban, a direct factor Xa inhibitor, inhibits tissue-factor induced human platelet aggregation in vitro: comparison with direct inhibitors of factor VIIa, XIa and thrombin.
Topics: Adenosine Diphosphate; Anticoagulants; Arginine; Azetidines; Benzimidazoles; Collagen; Dabigatran; Dose-Response Relationship, Drug; Factor VIIa; Factor Xa; Factor Xa Inhibitors; Factor XIa; Humans; Morpholines; Pipecolic Acids; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Sulfonamides; Thiophenes; Thrombin; Thromboplastin; Time Factors | 2010 |
Carbon monoxide releasing molecule-2 enhances coagulation and diminishes fibrinolytic vulnerability in plasma exposed to heparin or argatroban.
Topics: Anticoagulants; Arginine; Blood Coagulation; Coagulants; Fibrinolysis; Heparin; Humans; Kinetics; Organometallic Compounds; Pipecolic Acids; Sulfonamides; Thrombelastography; Thromboplastin; Tissue Plasminogen Activator | 2010 |
Ox brain versus rabbit brain thromboplastin assays are the best tool for a preliminary diagnosis of the Arg304Gln factor VII defect (FVII Padua).
Topics: Amino Acid Substitution; Animals; Arginine; Brain Chemistry; Cattle; Factor VII; Glutamine; Homozygote; Humans; Rabbits; Thromboplastin | 2010 |
Prothrombin activation on the activated platelet surface optimizes expression of procoagulant activity.
Topics: Arginine; Blood Coagulation; Enzyme Precursors; Factor Xa; Humans; Immunoblotting; Kinetics; Mutation; Peptide Fragments; Platelet Activation; Prothrombin; Thrombin; Thromboplastin | 2011 |
Increased plasma level of asymmetric dimethylarginine in hypertensive rats facilitates platelet aggregation: role of plasma tissue factor.
Topics: Animals; Arginine; Hypertension; Male; Platelet Aggregation; Random Allocation; Rats; Rats, Inbred WKY; Thromboplastin; Up-Regulation | 2011 |
Effects of anti-factor VIII inhibitor antibodies on factor VIIa/tissue factor-catalysed activation and inactivation of factor VIII.
Topics: Antibodies, Blocking; Arginine; Blood Coagulation; Catalysis; Dose-Response Relationship, Drug; Epitopes; Factor VIIa; Factor VIII; Humans; Hydrolysis; In Vitro Techniques; Protein Binding; Substrate Specificity; Thrombin; Thromboplastin | 2011 |
Cleavage at both Arg306 and Arg506 is required and sufficient for timely and efficient inactivation of factor Va by activated protein C.
Topics: Animals; Arginine; Blood Coagulation; Blood Coagulation Tests; Cell Membrane; Chlorocebus aethiops; COS Cells; Factor Va; Humans; Kinetics; Plasmids; Point Mutation; Protein Binding; Protein C; Recombinant Proteins; Thromboplastin; Transfection | 2011 |
Similarities and discrepancies in homozygous factor VII defects due to mutations in the region of residues Met298 to Cys310 (exon 8) in the catalytic domain of factor VII.
Topics: Adolescent; Adult; Amino Acid Sequence; Amino Acid Substitution; Animals; Arginine; Catalytic Domain; Cattle; Exons; Factor VII; Factor VII Deficiency; Female; Genotype; Heterozygote; Homozygote; Humans; Male; Middle Aged; Mutation; Phenotype; Rabbits; Thromboplastin | 2011 |
The thrombin inhibitor, argatroban, inhibits breast cancer metastasis to bone.
Topics: Animals; Antithrombins; Arginine; Body Weight; Bone Neoplasms; Breast Neoplasms; Enzyme-Linked Immunosorbent Assay; Female; Humans; Mice; Pipecolic Acids; Sulfonamides; Thrombin; Thromboplastin; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A | 2013 |
Elevated plasma factor VIII enhances venous thrombus formation in rabbits: contribution of factor XI, von Willebrand factor and tissue factor.
Topics: Animals; Antibodies, Blocking; Arginine; Blood Platelets; Factor VIII; Factor XI; Hemostasis; Humans; Jugular Veins; Male; Pipecolic Acids; Platelet Aggregation; Rabbits; Sulfonamides; Thrombin; Thromboplastin; Venous Thrombosis; von Willebrand Factor | 2013 |
Comparison of the aPTT with alternative tests for monitoring direct thrombin inhibitors in patient samples.
Topics: Antithrombins; Arginine; Benzimidazoles; beta-Alanine; Blood Coagulation; Blood Coagulation Tests; Dabigatran; Drug Monitoring; Heparin; Hirudins; Humans; Partial Thromboplastin Time; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombin; Thrombin Time; Thromboplastin | 2014 |
Argatroban more effectively inhibits the thrombin activity in synovial fluid than naturally occurring thrombin inhibitors.
Topics: Aged; Aged, 80 and over; Antithrombins; Arginine; Blood Coagulation; Cytokines; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Models, Biological; Pipecolic Acids; Sulfonamides; Synovial Fluid; Thrombin; Thromboplastin | 2016 |