arginine and simvastatin

arginine has been researched along with simvastatin in 34 studies

Research

Studies (34)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (8.82)	18.2507
2000's	13 (38.24)	29.6817
2010's	16 (47.06)	24.3611
2020's	2 (5.88)	2.80

Authors

Authors	Studies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
de Bruin, TW; Koomans, HA; Rabelink, TJ; Stroes, ES	1
Banga, JD; de Bruin, T; de Valk, H; Erkelens, W; Koomans, H; Rabelink, T; Stroes, E; van Rijn, H	1
Kakei, M; Nakata, M; Shiraishi, T; Yada, T	1
Dalkara, T; Endres, M; Huang, PL; Huang, Z; Laufs, U; Liao, JK; Moskowitz, MA; Waeber, C; Yamada, M	1
Abdalla, DS; Bersch, D; Bertolami, MC; Faludi, AA; Pereira, EC; Salem, M	1
Isomustajärvi, M; Laakso, J; Laaksonen, R; Lakka, TA; Lehtimäki, T; Päivä, H; Ruokonen, I; Salonen, JT; Valkonen, VP	1
Deng, HW; Jiang, DJ; Jiang, JL; Li, NS; Li, YJ; Tang, YH	1
Davis, NA; Inman, SR; Lukaszek, VA; Mazzone, ME; Olson, KM; Yoder, KN	1
Caldwell, RB; Caldwell, RW; El-Remessy, AB; Ma, G; Matragoon, S; Tawfik, HE	1
Carod-Artal, FJ	1
Deng, HW; Jiang, JL; Li, NS; Li, YJ; Wang, S; Zhang, XH	1
Benndorf, RA; Bierend, A; Böger, GI; Böger, RH; Dumbadze, E; Maas, R; Rudolph, TK; Schwedhelm, E	1
Kunes, J; L'upták, I; Matúsková, J; Pechánová, O; Simko, F; Török, J; Zicha, J	1
Amin, RS; Hassan, MK; Heeba, GH	1
Gryglewski, R; Hassan, M; Heeba, G; Khalifa, M; Malinski, T; Moselhy, ME	1
Altenburg, C; Beil, U; Benndorf, R; Böger, RH; Glos, S; Maas, R; Petruschka, D; Schulze, F; Schwedhelm, E	1
Ao, Z; Bradley, BT; Ivashchenko, CY; Johns, DG; Leiper, J; Vallance, P	1
Deneva, TI; Marinov, B; Vladimirova-Kitova, LG	1
Deneva-Koycheva, T; Vladimirova-Kitova, LG	1
Agrawal, A; Ahmad, T; Aich, J; Ghosh, B; Mabalirajan, U; Makhija, L; Sharma, A	1
Deneva, TI; Vladimirova-Kitova, LG	1
Bratt, JM; Kenyon, NJ; Last, JA; Rabowsky, M; Zeki, AA	1
Bernard, M; Berthe, MC; Couderc, R; Cynober, L; Darquy, S; Rasmusen, C	1
Glutkina, NV	1
Majeed, AB; Meor Mohd Affandi, MM; Shah, SA; Tripathy, M	1
Guo, BC; Hsu, CP; Lee, TS; Lin, SJ; Lu, TM; Shyue, SK; Zhao, JF	1
Carru, C; Ena, S; Mangoni, AA; Satta, AE; Sotgia, S; Sotgiu, E; Zinellu, A	1
Kang, YS; Tun, T	1
Affandi, MMRMM; Majeed, ABA; Tripathy, M	1
Böger, R; Choe, CU; Cordts, K; Gerloff, C; Grzybowski, R; Hanff, E; Hornig, S; Isbrandt, D; Neu, A; Sasani, A; Schwedhelm, E; Tsikas, D	1
Degrush, E; Drachman, D; Gounis, MJ; Henninger, N; Lindsay, C; Shazeeb, MS; Vardar, Z	1

Reviews

1 review(s) available for arginine and simvastatin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

8 trial(s) available for arginine and simvastatin

Article	Year
NO activity in familial combined hyperlipidemia: potential role of cholesterol remnants. Cardiovascular research, 1997, Volume: 36, Issue:3 Topics: Adult; Arginine; Cholesterol; Endothelium, Vascular; Forearm; Humans; Hyperlipoproteinemia Type II; Hypolipidemic Agents; Lipoproteins; Male; Middle Aged; Nitric Oxide; Nitroprusside; Regional Blood Flow; Serotonin; Simvastatin; Vasodilation	1997
Effects of simvastatin and L-arginine on vasodilation, nitric oxide metabolites and endogenous NOS inhibitors in hypercholesterolemic subjects. Free radical research, 2003, Volume: 37, Issue:5 Topics: Anticholesteremic Agents; Arginine; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Free Radicals; Humans; Hypercholesterolemia; Lipids; Male; Middle Aged; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; S-Nitrosothiols; Simvastatin; Time Factors; Vasodilation	2003
Asymmetrical dimethylarginine (ADMA) and risk of acute coronary events. Does statin treatment influence plasma ADMA levels? Atherosclerosis. Supplements, 2003, Volume: 4, Issue:4 Topics: Acute Disease; Adult; Aged; Arginine; Atorvastatin; Biomarkers; Blood Glucose; Case-Control Studies; Cholesterol, HDL; Cholesterol, LDL; Coronary Disease; Double-Blind Method; Endothelium, Vascular; Enzyme Inhibitors; Female; Finland; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Male; Middle Aged; Prospective Studies; Pyrroles; Risk Factors; Simvastatin; Statistics as Topic; Triglycerides	2003
Asymmetric dimethylarginine determines the improvement of endothelium-dependent vasodilation by simvastatin: Effect of combination with oral L-arginine. Journal of the American College of Cardiology, 2007, Jun-12, Volume: 49, Issue:23 Topics: Aged; Aged, 80 and over; Arginine; C-Reactive Protein; Drug Therapy, Combination; Endothelium, Vascular; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins; Male; Middle Aged; Nitric Oxide Synthase Type III; Simvastatin; Vasodilation	2007
L-Arginine enhances the triglyceride-lowering effect of simvastatin in patients with elevated plasma triglycerides. Nutrition research (New York, N.Y.), 2009, Volume: 29, Issue:5 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anticholesteremic Agents; Arginine; Aspartate Aminotransferases; Dietary Supplements; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Female; Fibrinogen; Humans; Hypertriglyceridemia; Hypolipidemic Agents; Male; Middle Aged; Placebos; Simvastatin; Triglycerides	2009
Effect of moderate and high-dose simvastatin on asymmetric dimethylarginine-homocysteine metabolic pathways in patients with newly detected severe hypercholesterolemia. Cardiovascular therapeutics, 2011, Volume: 29, Issue:5 Topics: Adult; Arginine; Biomarkers; Bulgaria; Cholesterol, LDL; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Homocysteine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Prospective Studies; Severity of Illness Index; Simvastatin; Time Factors; Treatment Outcome	2011
Simvastatin and asymmetric dimethylarginine-homocysteine metabolic pathways in patients with newly detected severe hypercholesterolemia. Clinical laboratory, 2010, Volume: 56, Issue:7-8 Topics: Adult; Anticholesteremic Agents; Arginine; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Homocysteine; Humans; Hypercholesterolemia; Lipids; Male; Simvastatin; Treatment Outcome	2010
Asymmetric Dimethylarginine Limits the Efficacy of Simvastatin Activating Endothelial Nitric Oxide Synthase. Journal of the American Heart Association, 2016, Apr-18, Volume: 5, Issue:4 Topics: Aged; Animals; Arginine; Cardiovascular Diseases; Endothelium, Vascular; Enzyme Activation; Female; Humans; Male; Mice; Nitric Oxide; Nitric Oxide Synthase Type III; Reactive Oxygen Species; Signal Transduction; Simvastatin	2016

Other Studies

25 other study(ies) available for arginine and simvastatin

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Vascular function in the forearm of hypercholesterolaemic patients off and on lipid-lowering medication. Lancet (London, England), 1995, Aug-19, Volume: 346, Issue:8973 Topics: Adult; Arginine; Blood Pressure; Cholesterol; Cholestyramine Resin; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Forearm; Humans; Hyperlipoproteinemia Type II; Hypolipidemic Agents; Infusions, Intravenous; Lovastatin; Male; Nitroprusside; omega-N-Methylarginine; Regional Blood Flow; Serotonin; Simvastatin; Vasodilation	1995
Inhibition by simvastatin, but not pravastatin, of glucose-induced cytosolic Ca2+ signalling and insulin secretion due to blockade of L-type Ca2+ channels in rat islet beta-cells. British journal of pharmacology, 1999, Volume: 126, Issue:5 Topics: Animals; Arginine; Calcium; Calcium Channel Blockers; Calcium Channels; Cytosol; Glucose; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin; Insulin Secretion; Islets of Langerhans; Potassium Chloride; Pravastatin; Rats; Signal Transduction; Simvastatin	1999
Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2000, Volume: 20, Issue:4 Topics: Animals; Arginine; Arterial Occlusive Diseases; Cerebral Arteries; Cerebrovascular Circulation; Drug Synergism; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Mice, Inbred Strains; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Simvastatin; Time Factors	2000
Effect of simvastatin on endothelium-dependent vaso-relaxation and endogenous nitric oxide synthase inhibitor. Acta pharmacologica Sinica, 2004, Volume: 25, Issue:7 Topics: Animals; Arginine; Cell Adhesion; Cells, Cultured; Endothelium, Vascular; Humans; Lipoproteins, LDL; Male; Monocytes; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Simvastatin; Tumor Necrosis Factor-alpha; Umbilical Cord; Vasodilation	2004
Simvastatin and L-arginine preserve renal function after ischemia/reperfusion injury. The American journal of the medical sciences, 2005, Volume: 329, Issue:1 Topics: Animals; Arginine; Cyclosporine; Drug Therapy, Combination; Glomerular Filtration Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunosuppressive Agents; Kidney Diseases; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Random Allocation; Rats; Rats, Wistar; Reperfusion Injury; Simvastatin	2005
Simvastatin improves diabetes-induced coronary endothelial dysfunction. The Journal of pharmacology and experimental therapeutics, 2006, Volume: 319, Issue:1 Topics: Animals; Arginine; Coronary Vessels; Diabetes Mellitus, Experimental; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Sprague-Dawley; Simvastatin; Streptozocin; Superoxides; Tyrosine; Vasodilation	2006
Statins and cerebral vasomotor reactivity: implications for a new therapy? Stroke, 2006, Volume: 37, Issue:10 Topics: Adult; Animals; Arginine; Atorvastatin; Brain Ischemia; Cerebrovascular Circulation; Clinical Trials, Phase II as Topic; Endothelium, Vascular; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertension; Intracranial Aneurysm; Mice; Middle Cerebral Artery; Nitric Oxide; Pravastatin; Pyrroles; Randomized Controlled Trials as Topic; Research Design; Risk Factors; Simvastatin; Stroke; Subarachnoid Hemorrhage; Ultrasonography, Doppler, Transcranial; Vasodilation; Vasomotor System; Vasospasm, Intracranial	2006
The inhibitory effect of simvastatin on the ADMA-induced inflammatory reaction is mediated by MAPK pathways in endothelial cells. Biochemistry and cell biology = Biochimie et biologie cellulaire, 2007, Volume: 85, Issue:1 Topics: Arginine; Cells, Cultured; Endothelial Cells; Endothelium, Vascular; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intercellular Adhesion Molecule-1; MAP Kinase Signaling System; NF-kappa B; Nitric Oxide Synthase; Phosphorylation; Protein Kinase Inhibitors; Signal Transduction; Simvastatin; Tumor Necrosis Factor-alpha	2007
Comparison of the effect of simvastatin, spironolactone and L-arginine on endothelial function of aorta in hereditary hypertriglyceridemic rats. Physiological research, 2007, Volume: 56 Suppl 2 Topics: Acetylcholine; Animals; Aorta; Arginine; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertriglyceridemia; Male; Mineralocorticoid Receptor Antagonists; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Norepinephrine; Rats; Rats, Wistar; Simvastatin; Spironolactone; Time Factors; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents	2007
Gastroprotective effect of simvastatin against indomethacin-induced gastric ulcer in rats: role of nitric oxide and prostaglandins. European journal of pharmacology, 2009, Apr-01, Volume: 607, Issue:1-3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arginine; Dinoprostone; Drug Interactions; Drug Synergism; Enzyme Inhibitors; Gastric Juice; Gastric Mucosa; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Simvastatin; Stomach Ulcer	2009
Anti-atherogenic effect of statins: role of nitric oxide, peroxynitrite and haem oxygenase-1. British journal of pharmacology, 2009, Volume: 156, Issue:8 Topics: Animals; Aorta; Arginine; Atherosclerosis; Atorvastatin; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Heme Oxygenase-1; Hemin; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Peroxidation; Male; Malondialdehyde; Metalloporphyrins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Protoporphyrins; Pyrroles; Rabbits; Simvastatin; Time Factors	2009
Regulation of the ADMA-DDAH system in endothelial cells: a novel mechanism for the sterol response element binding proteins, SREBP1c and -2. American journal of physiology. Heart and circulatory physiology, 2010, Volume: 298, Issue:1 Topics: Amidohydrolases; Arginine; Blotting, Western; Cells, Cultured; Chromatin; Chromatography, High Pressure Liquid; DNA Primers; Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoprecipitation; Lentivirus; Nitrites; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Simvastatin; Sterol Regulatory Element Binding Protein 1; Sterol Regulatory Element Binding Protein 2; Transfection	2010
Asymmetric dimethylarginine--a determinant of the effect of the high dose Simvastatin. Clinical biochemistry, 2010, Volume: 43, Issue:10-11 Topics: Adult; Arginine; Female; Humans; Hypercholesterolemia; Male; Middle Aged; Simvastatin; Vasodilation	2010
Simvastatin improves epithelial dysfunction and airway hyperresponsiveness: from asymmetric dimethyl-arginine to asthma. American journal of respiratory cell and molecular biology, 2011, Volume: 44, Issue:4 Topics: Airway Remodeling; Animals; Arginine; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Count; Chronic Disease; Disease Models, Animal; Epithelial Cells; Epithelium; Lung; Male; Mice; Mice, Inbred BALB C; Mucus; Nitric Oxide; Nitric Oxide Synthase Type III; Nitrosation; Pneumonia; Simvastatin; Stress, Physiological	2011
Simvastatin inhibits goblet cell hyperplasia and lung arginase in a mouse model of allergic asthma: a novel treatment for airway remodeling? Translational research : the journal of laboratory and clinical medicine, 2010, Volume: 156, Issue:6 Topics: Aerosols; Animals; Arginase; Arginine; Asthma; Blotting, Western; Coloring Agents; Disease Models, Animal; Goblet Cells; Hydroxyproline; Hyperplasia; Immunohistochemistry; Inflammation; Lung; Mice; Nitrates; Nitrites; Ovalbumin; Simvastatin; Transforming Growth Factor beta1	2010
Arginine or citrulline associated with a statin stimulates nitric oxide production in bovine aortic endothelial cells. European journal of pharmacology, 2011, Nov-30, Volume: 670, Issue:2-3 Topics: Animals; Aorta; Arginine; Argininosuccinate Lyase; Cattle; Caveolin 1; Citrulline; Drug Interactions; Endothelial Cells; Gene Expression Regulation, Enzymologic; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Simvastatin	2011
[Effect of simvastatin on the oxygen transport function and prooxidant - antioxidant balance in blood]. Eksperimental'naia i klinicheskaia farmakologiia, 2013, Volume: 76, Issue:4 Topics: Animals; Anticholesteremic Agents; Antioxidants; Arginine; Biological Transport; Dose-Response Relationship, Drug; Hemoglobins; Nitric Oxide; Oxygen; Rats; Simvastatin	2013
Solubility enhancement of simvastatin by arginine: thermodynamics, solute-solvent interactions, and spectral analysis. Drug design, development and therapy, 2016, Volume: 10 Topics: Arginine; Magnetic Resonance Spectroscopy; Molecular Conformation; Simvastatin; Solubility; Solvents; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Thermodynamics; Water	2016
Effect of cholesterol lowering treatment on plasma markers of endothelial dysfunction in chronic kidney disease. Journal of pharmaceutical and biomedical analysis, 2016, Sep-10, Volume: 129 Topics: Allantoin; Anticholesteremic Agents; Arginine; Biomarkers; Cholesterol; Endothelium; Ezetimibe; Female; Humans; Inflammation; Kynurenine; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Renal Insufficiency, Chronic; Simvastatin; Uric Acid	2016
Effects of simvastatin on CAT-1-mediated arginine transport and NO level under high glucose conditions in conditionally immortalized rat inner blood-retinal barrier cell lines (TR-iBRB). Microvascular research, 2017, Volume: 111 Topics: Animals; Arginine; Biological Transport; Blood-Retinal Barrier; Cationic Amino Acid Transporter 1; Cell Line; Diabetic Retinopathy; Glucose; Nitric Oxide; Nitric Oxide Synthase Type III; Rats; RNA, Messenger; Simvastatin; Time Factors; Up-Regulation	2017
Arginine Complexes with Simvastatin: Apparent Solubility, In Vitro Dissolution and Solid State Characterization. Current drug delivery, 2018, Volume: 15, Issue:1 Topics: Arginine; Calorimetry, Differential Scanning; Hydrogen-Ion Concentration; Microscopy, Electron, Scanning; Powder Diffraction; Simvastatin; Solubility; Temperature; Water	2018
Muscle phenotype of AGAT- and GAMT-deficient mice after simvastatin exposure. Amino acids, 2020, Volume: 52, Issue:1 Topics: Animals; Arginine; Creatine; DNA Modification Methylases; DNA Repair Enzymes; Gene Expression Regulation; Guanidinoacetate N-Methyltransferase; Homoarginine; Humans; Mice; Muscle, Skeletal; Phenotype; Simvastatin; Tumor Suppressor Proteins	2020
Cumulative effect of simvastatin, L-arginine, and tetrahydrobiopterin on cerebral blood flow and cognitive function in Alzheimer's disease. Alzheimer's research & therapy, 2022, 09-17, Volume: 14, Issue:1 Topics: Alzheimer Disease; Arginine; Biopterins; Cerebrovascular Circulation; Cognition; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Neuropsychological Tests; Nitric Oxide Synthase Type III; Proof of Concept Study; Simvastatin	2022