arginine and sapropterin

arginine has been researched along with sapropterin in 230 studies

Research

Studies (230)

TimeframeStudies, this research(%)All Research%
pre-19901 (0.43)18.7374
1990's83 (36.09)18.2507
2000's101 (43.91)29.6817
2010's41 (17.83)24.3611
2020's4 (1.74)2.80

Authors

AuthorsStudies
Gross, SS; Levi, R1
Bult, H; Herman, AG; Jorens, PG; van Overveld, FJ; Vermeire, PA1
Böhme, E; Heinzel, B; John, M; Klatt, P; Mayer, B; Schmidt, K1
Van Amsterdam, JG; Wemer, J1
Ishihara, T; Kanai, T; Noguchi, T; Nunokawa, Y1
Böhme, E; Heinzel, B; John, M; Klatt, P; Mayer, B1
Datto, GA; Wolff, DJ1
Fleming, I; Gray, GA; Schott, C; Stoclet, JC1
Busse, R; Mülsch, A1
Campos, KL; Giovanelli, J; Kaufman, S1
Gross, SS; Jaffe, EA; Kilbourn, RG; Levi, R1
Böhme, E; Heinzel, B; John, M; Mayer, B; Schultz, G; Wachter, H; Werner, ER1
Förstermann, U; Mitchell, JA; Murad, F; Sheng, H1
Marletta, MA; Tayeh, MA1
Billiar, TR; Di Silvio, M; Freeswick, P; Geller, DA; Gross, SS; Nussler, A; Simmons, RL1
Fukuto, JM; Griscavage, JM; Ignarro, LJ; Komori, Y1
Klatt, P; Mayer, B; Schmidt, K; Werner, ER1
Billiar, TR; Di Silvio, M; Freeswick, PD; Geller, DA; Lancaster, JR; Liu, ZZ; Lowenstein, CL; Nussler, AK; Simmons, RL; Sweetland, MA1
Chen, Y; Rosazza, JP1
Doppler, W; Fuchs, D; Goossen, B; Grünewald, K; Hentze, MW; Pantopoulos, K; Wachter, H; Weiss, G; Werner-Felmayer, G1
McCreedy, SA; Reif, DW1
Brand, MP; Clark, JB; Heales, SJ; Land, JM1
Bächinger, HP; Glatter, O; Klatt, P; Lehner, D; Mayer, B; Schmidt, K1
Hofmann, H; Schmidt, HH1
Blau, N; Guerrero, L; Hofer, S; Schaffner, A; Schneemann, M; Schoedon, G1
Klatt, P; Mayer, B; Schmidt, K; Uray, G1
Kim, YM; Lancaster, JR1
Lancaster, JR; Wachter, H; Werner-Felmayer, G1
Heyes, MP; Kaufman, S; Milstien, S; Saito, K; Sakai, N1
Citron, BA; Davis, MD; Greene, CL; Kaufman, S; Milstien, S; Naylor, EW1
Lincoln, J; Messersmith, WA1
Albakri, QA; Stuehr, DJ1
Gerber, NC; Ortiz de Montellano, PR; Rodríguez-Crespo, I1
Giovanelli, J; Kaufman, S; Witteveen, CF2
Bächinger, HP; Glatter, O; Klatt, P; Lehner, D; List, BM; Mayer, B; Pfeiffer, S; Schmidt, K; Werner, ER1
Boyhan, A; Charles, I; Lowe, PN; Moncada, S; Riveros-Moreno, V; Smith, D; Stammers, DK1
Cañada, FJ; Lamas, S; Pérez-Sala, D; Saura, M1
Klatt, P; List, BM; Mayer, B; Schmidt, K; Werner, ER1
Hertelendy, F; Kukor, Z; Mészáros, G; Tóth, M1
Calaycay, JR; Chabin, RM; Hutchinson, NI; Kelly, TM; Kozarich, JW; MacNaul, KL; Madhusudanaraju, S; McCauley, E; Schmidt, JA; Wolfe, GC; Wong, KK1
Kelly, RA; Simmons, WW; Smith, GK; Smith, TW; Ungureanu-Longrois, D1
Eberhardt, W; Hummel, R; Kunz, D; Mühl, H; Nitsch, D; Pfeilschifter, J; Plüss, C; Walker, G1
Blau, N; Linscheid, P; Schaffner, A; Schneemann, M; Schoedon, G; Walter, R1
Ju, H; Ryan, JW; Venema, RC; Venema, VJ; Zou, R1
Cosentino, F; Erkelens, W; Kastelein, J; Koomans, H; Lüscher, T; Rabelink, T; Stroes, E; Wever, R1
Gerber, NC; Nishida, CR; Ortiz de Montellano, PR; Rodriguez-Crespo, I1
Gorren, AC; Mayer, B; Schmidt, K; Schrammel, A2
Crane, BR; Gachhui, R; Ghosh, DK; Parkinson, J; Stuehr, DJ; Wu, C1
Boyhan, A; Charles, IG; Lowe, PN; Saqi, M; Smith, D1
Abu-Soud, HM; Gachhui, R; Raushel, FM; Stuehr, DJ1
Beasjours, S; Guo, Y; Hussain, SN; Mori, M; Ward, ME1
Loehr, TM; Moënne-Loccoz, P; Ortiz de Montellano, PR; Rodríguez-Crespo, I1
Brand, MP; Heales, SJ; Lindley, KJ; Milla, PJ; Rolfe, VE1
Arvai, AS; Crane, BR; Gachhui, R; Getzoff, ED; Ghosh, DK; Stuehr, DJ; Tainer, JA; Wu, C1
Harrison, DG1
Nishida, CR; Ortiz de Montellano, PR1
Arvai, AS; Crane, BR; Getzoff, ED; Ghosh, DK; Stuehr, DJ; Tainer, JA; Wu, C1
Alderton, WK; Boyhan, A; Lowe, PN1
Ishii, M; Momose, K; Shimizu, S; Yamamoto, T1
Kaufman, S; Liang, LP1
Daff, S; Ito, O; Nomura, S; Sagami, I; Sato, H; Shimizu, T1
Hogg, N; Kalyanaraman, B; Karoui, H; Martásek, P; Masters, BS; Pritchard, KA; Tordo, P; Vásquez-Vivar, J1
Daff, S; Nakano, K; Sagami, I; Shimizu, T1
Berka, V; Tsai, AL; Xia, Y; Zweier, JL1
Marletta, MA; Rusche, KM; Spiering, MM1
Hurshman, AR; Marletta, MA; Rusche, KM1
Gross, SS; Ikeda-Saito, M; Liu, Q; Martásek, P; Masters, BS; Migita, CT; Miller, RT; Raman, CS; Roman, LJ; Salerno, JC1
Andrew, PJ; Brunner, K; Hemmens, B; Kungl, AJ; Mayer, B; Tortschanoff, A1
Daff, S; Sagami, I; Sato, H; Shimizu, T1
Dolphin, E; Fischmann, TO; Fossetta, JD; Hruza, A; Lundell, DJ; Lunn, CA; Narula, SK; Niu, XD; Prongay, AJ; Reichert, P; Weber, PC1
Boyington, JC; Kulansky, R; Malech, HL; Rafferty, SP; Sun, PD1
Ludwig, ML; Marletta, MA1
McMurtry, IF; Rodman, DM; Sato, K1
Bhagat, K; Charles, IG; Hingorani, AD; Palacios, M; Vallance, P1
Berka, V; Lambry, JC; Liebl, U; Martin, JL; Négrerie, M; Tsai, AL; Vos, MH1
Bömmel, HM; Frey, A; Fröhlich, LG; Kotsonis, P; Pfleiderer, W; Reif, A; Schmidt, HH; Wink, DA1
Hogg, N; Kalyanaraman, B; Karoui, H; Martásek, P; Pritchard, KA; Vásquez-Vivar, J1
Boucher, JL; Moali, C; Tenu, JP1
Cosentino, F; Lüscher, TF1
Ishii, M; Kawakami, Y; Kiuchi, Y; Momose, K; Shimizu, S; Yamamoto, T1
Edmondson, DE; Hurshman, AR; Huynh, BH; Krebs, C; Marletta, MA1
Andrew, PJ; Mayer, B1
Fröhlich, LG; Horejsi, R; Kotsonis, P; Pfleiderer, W; Schmidt, HH; Shutenko, ZV1
Huang, A; Keaney, JF; Venema, RC; Vita, JA1
Arvai, AS; Crane, BR; Getzoff, ED; Ghosh, S; Stuehr, DJ; Tainer, JA1
Daff, S; Sagami, I; Sato, Y; Shimizu, T1
Hatakeyama, K; Kelly, KA; Marinos, RS; Martinez-Zaguilan, R; Meininger, CJ; Rojas, JD; Wu, G1
Berka, V; Tsai, AL1
Kankaanranta, H; Lähde, M; Lahti, A; Moilanen, E1
Adak, S; Stuehr, DJ; Wang, Q1
Ghosh, DK; Jung, C; Stuehr, DJ1
Bec, N; Gorren, AC; Lange, R; Mayer, B; Schrammel, A; Werner, ER1
Hemann, C; Hille, R; Meade, AL; Stuehr, DJ; Wang, Q; Wang, ZQ; Wei, CC1
Hurt, RD; Miller, VM; Severson, SR; Tonnessen, BH1
Bruner, E; Magde, D; Martásek, P; Masters, BS; Roman, LJ; Scheele, JS; Sharma, VS; Zemojtel, T1
Jiang, J; Pernow, J; Thorén, P; Tokuno, S; Valen, G1
Cioffi, FA; d'Ischia, M; Palumbo, A1
Assreuy, J; Guimarães, C; Linden, R1
Furukawa, A; Ichikawa, M; Ichikawa, Y; Jiang, H; Ohnishi, T; Tomita, S1
Boucher, JL; Mansuy, D; Moali, C; Renodon-Corniere, A; Stuehr, DJ1
Gräbner, R; Heller, R; Malle, E; Marsche, G; Nuszkowski, A; Unbehaun, A1
Daff, S; Noguchi, T; Sagami, I; Shimizu, T1
Blum, M; Chernichowski, T; Iaina, A; Levo, Y; Schwartz, D; Schwartz, IF; Wollman, Y1
Astarita, G; d'Ischia, M; Palumbo, A1
Tiefenbacher, CP1
Prabhakar, SS1
Hori, M; Karaki, H; Murata, T; Ozaki, H; Sato, K; Yamawaki, H1
Cosper, NJ; Hori, H; Iwasaki, T; Nishino, T; Scott, RA1
Ghosh, S; Hemann, C; Hille, R; Meade, AL; Stuehr, DJ; Wang, ZQ; Wei, CC1
Ishii, M; Iwasaki, M; Kiuchi, Y; Shimizu, S; Shiota, K; Yamamoto, T1
Berka, V; Lambry, JC; Martin, JL; Négrerie, M; Slama-Schwok, A; Tsai, AL; Vos, MH1
George, SC; Kwon, S; Newcomb, RL1
d'Ischia, M; Napolitano, A; Palumbo, A1
Dunster, C; Grieve, DJ; Kelly, FJ; Li, JM; MacCarthy, PA; Shah, AM1
Conrad, KP; Davis, AK; Novak, J; Powers, RW1
Adak, S; Aulak, KS; Bilwes, AM; Crane, BR; Getzoff, ED; Hosfield, D; McDonald, JF; Panda, K; Stuehr, DJ; Tainer, JA1
Lüscher, TF; Noll, G; Spieker, LE1
Adak, S; Aulak, KS; Stuehr, DJ1
Hurshman, AR; Marletta, MA1
Joseph, J; Kalyanaraman, B; Martásek, P; Vásquez-Vivar, J; Whitsett, J1
Tóth, M1
Torreilles, F; Touchon, J1
Ishii, M; Kiuchi, Y; Shimizu, S; Shiota, K; Yamamoto, S; Yamamoto, T1
Himi, N; Hirano, K; Kajiya, F; Miyasaka, T; Mochizuki, S; Nakamoto, H; Ogasawara, Y; Takemoto, M; Tsujioka, K1
Gorren, AC; Mayer, B; Schmidt, K1
Boucher, JL; Mansuy, D1
McDonald, JF; Meade, AL; Stuehr, DJ; Wang, ZQ; Wei, CC1
Marks, N; Wolff, DJ1
Arvai, AS; Getzoff, ED; Hemann, C; Hille, R; Stuehr, DJ; Wang, ZQ; Wei, CC1
Fujii, S; Igarashi, J; Kosaka, H; Yamamoto, A; Yoneyama, H; Zhang, L1
Boucher, JL; Desbois, A; Frapart, Y; Gorren, AC; Lefèvre-Groboillot, D; Mansuy, D; Mayer, B; Stuehr, DJ; Zimmermann, JL1
Ishii, M; Kiuchi, Y; Miyasaka, Y; Mori, Y; Nishida, M; Shimizu, S; Shiota, K; Watabe, T; Yamamoto, S; Yamamoto, T1
Ghosh, S; Mukherjee, S; Regulski, M; Sahoo, R; Sengupta, R; Stuehr, DJ; Tully, T1
Benchetrit, S; Bernheim, J; Podjarny, E; Pomeranz, A; Rashid, G; Rathaus, M; Shapira, J1
Sagami, I; Sato, Y; Shimizu, T1
Hemann, C; Hille, R; Stuehr, DJ; Wang, ZQ; Wei, CC1
Edmondson, DE; Hurshman, AR; Krebs, C; Marletta, MA1
Berka, V; Palmer, G; Tsai, AL; Wu, G; Yeh, HC1
Kurabayashi, M; Morita, H; Nagai, R; Nakamura, T; Saito, Y1
Hirata, Y1
Boucher, JL; Brunet, A; David-Dufilho, M; Devynck, MA; Millanvoye, E; Rendu, F; Topal, G1
deBlois, D; Der Sarkissian, S; Duguay, D; Marchand, EL1
Kotsonis, P; Matter, H1
Bernheim, J; Green, J; Hasdan, G; Korzets, Z; Podjarny, E; Rashid, G1
Bauersachs, J; Schäfer, A1
Feelisch, M; Reif, A; Schmidt, HH; Shutenko, ZV1
Cherian, L; Hlatky, R; Robertson, CS1
Berka, V; Gao, D; Kiran, F; Tsai, AL; Yeh, HC1
Ayajiki, K; Okamura, T; Shinozaki, K1
Cardounel, AJ; Xia, Y; Zweier, JL1
Durra, D; Garcin, ED; Getzoff, ED; Hemann, C; Hille, R; Stuehr, DJ; Wang, ZQ; Wei, CC1
Panda, K; Santolini, J; Stuehr, DJ; Wang, Q; Wang, ZQ; Wei, CC1
Jáchymová, M; Kalyanaraman, B; Martásek, P; Porter, R; Vásquez-Vivar, J1
Arteaga, E; Black, SM; Chace, DH; Fink, R; Ravi, K; Wainwright, MS1
Kajiya, F; Kashihara, N; Kimoto, M; Miyasaka, T; Mochizuki, S; Ogasawara, Y; Ono, J; Yada, T1
Black, SM; Farrow, KN; Jenkins, C; Konduri, GG; Lakshminrusimha, S; Mata-Greenwood, E; Russell, JA; Steinhorn, RH1
Bryan, RM; Durante, W; Jiang, X; Liao, D; Randhawa, JK; Rumbaut, RE; Schafer, AI; Tan, H; Wang, H; Yang, F; Yang, X1
Bevers, LM; Braam, B; Joles, JA; Koomans, HA; Post, JA; Rabelink, TJ; van Zonneveld, AJ; Verhaar, MC1
Boucher, JL; Lefèvre-Groboillot, D; Mansuy, D; Stuehr, DJ1
Andersson, KK; Gorren, AC; Lange, R; Marchal, S; Mayer, B; Sørlie, M1
Deng, H; Hayden, EY; Li, D; Panda, K; Rousseau, DL; Stuehr, DJ; Yeh, SR1
Abu-Soud, HM; Diamond, MP; Saed, GM; Zhao, M1
Hiroi, T; Ishii, M; Kiuchi, Y; Shimizu, S; Wajima, T1
Corti, R; Flammer, A; Hermann, F; Lüscher, TF; Noll, G; Spieker, LE; Sudano, I1
Gorren, AC; Mayer, B; Nedeianu, S; Pignitter, M; Schmidt, K1
Hillier, IH; Joule, JA; Morao, I; Periyasamy, G1
Fekkes, D; Hoekstra, R; Loonen, AJ; Pepplinkhuizen, L; Tuinier, S; Verhoeven, WM1
Ayajiki, K; Gemba, M; Okamura, T; Shinozaki, K; Yamamizu, K1
Gao, YT; Ishimura, Y; Martásek, P; Masters, BSS; Panda, SP; Roman, LJ1
Akasaka, T; Kaji, S; Kajiya, F; Mochizuki, S; Ogasawara, Y; Tanemoto, K; Yada, T; Yoshida, K1
Bhattacharjee, A; Dutta, T; Ghosh, S; Ray, SS; Regulski, M; Stuehr, DJ; Tejero, J; Tully, T; Wang, ZQ1
Berka, V; Tsai, AL; Wang, LH1
Behnke, BJ; Delp, MD; Muller-Delp, JM; Spier, SA; Wu, G1
Hemann, C; Hille, R; Stuehr, DJ; Tejero, J; Wang, ZQ; Wei, CC; Yang, YP1
Heffernan, KS; Valentine, RJ; Vieira, VJ1
Cardounel, AJ; Chen, CA; Druhan, LJ; Forbes, SP; Pope, AJ; Zweier, JL1
Datta, S; Kim, SW; Li, P; Li, X; Pond, WG; Wu, G1
Christensen, JC; Fleck, JD; Glaser, C; Hyland, K; Martin, KW; Roy-Burman, A; Rupprecht, CE; Westenkirschner, DF; Willoughby, RE1
Biswas, A; Haque, MM; Hemann, C; Misra, S; Page, RC; Stuehr, DJ; Tejero, J; Wang, ZQ; Zweier, JL1
Böhm, F; Channon, KM; Malmström, RE; Pernow, J; Settergren, M1
Bommassar, C; Golderer, G; Gröbner, P; Leitner, S; Messner, S; Werner, ER; Werner-Felmayer, G1
Boucher, JL; Fournet-Bourguignon, MP; Frapart, Y; Gosgnach, W; Lesage, L; Molez, S; Perrier, E; Reure, H; Royere, E; Vilaine, JP; Villeneuve, N1
Boontje, NM; de Crom, R; de Waard, MC; Dekkers, DH; Duncker, DJ; Kuster, DW; Lamers, JM; van der Velden, J; van Haperen, R1
Davidge, ST; Sankaralingam, S; Xu, H1
Deutz, NE; Engelen, MP; Luiking, YC1
Daneshtalab, N; Smeda, JS1
Arellano-Mendoza, MG; Castorena-Torres, F; Coronel, I; del Valle-Mondragon, L; Escalante, B; Rios, A; Romo, E; Vargas-Robles, H1
Boegehold, MA; Li, P; Nurkiewicz, TR; Wu, G1
Förstermann, U1
Delgado, C; Ruiz-Hurtado, G1
Gielis, JF; Lin, JY; Moens, AL; Schmidt, HH; Van Schil, PE; Wingler, K1
Bonilla, I; Cardounel, AJ; Carnes, CA; Elton, TS; Györke, S; Khan, M; Kuppusamy, P; Li, C; Nishijima, Y; Sridhar, A; Terentyev, D; Terentyeva, R; Velayutham, M; Zweier, JL1
Holowatz, LA; Kenney, WL1
Förstermann, U; Sessa, WC1
Boucher, JL; Mansuy, D; Salard-Arnaud, I; Stuehr, D1
Boegehold, MA; Kang, LS; Nurkiewicz, TR; Wu, G1
Biswas, A; Fadlalla, M; Haque, MM; Santolini, J; Stuehr, DJ; Tejero, J; Wang, ZQ; Wei, CC1
Bino, L; Kadlec, J; Klinke, A; Kubala, L; Kuchta, R; Lau, D; Lojek, A; Martiskova, H; Pekarova, M; Vasicek, O; Vrba, R1
Messina, LM; Tie, G; Yan, J2
Bernad, S; Brunel, A; Dorlet, P; Santolini, J; Sicard-Roselli, C1
Benedito, S; Climent, B; Contreras, C; García-Sacristán, A; Hernández, M; Martínez, MP; Prieto, D; Sánchez, A1
Aramburo, A; Black, SM; Fineman, JR; Kalkan, G; Kallarackal, S; Kumar, S; Rafikov, R; Rehmani, I; Sharma, S; Sun, X; Tian, J1
Choi, YH; Noh, JS; Song, YO1
Brunel, A; Dorlet, P; Santolini, J1
Fung, HL; Mohan, S1
Hoang, HH; Meininger, CJ; Padgham, SV1
Beatty, KM; Chen, AF; Ghosh, A; Li, F; Liu, H; McKenna, KC; Scherder, RC; Stuehr, DJ1
Stuehr, D; Tejero, J1
Ghosh, A; Haque, MM; Mukherjee, N; Nagpal, L; Panda, K; Ranu, BC; Saha, A; Stuehr, DJ1
Cottin, Y; Guilland, JC; Lorin, J; Rochette, L; Vergely, C; Zeller, M1
Bange, FC; Georgieva, M; Jung, JY; Madan-Lala, R; Rengarajan, J; Robinson, CM; Sohaskey, CD1
Bergmeister, H; Bonderman, D; Jakowitsch, J; Lang, IM; Mascherbauer, J; Panzenböck, A; Schreiber, C; Strobl, M; Wexberg, P; Winter, MP1
Adamo, RF; Alferiev, IS; Chorny, M; Fishbein, I; Forbes, SP; Levy, RJ1
Böhm, F; Channon, KM; Gonon, AT; Kiss, A; Pernow, J; Settergren, M; Sjöquist, PO; Tornvall, P; Tratsiakovich, Y; Yang, J1
Bayatli, N; Gur, S; Kaya, E; Un, O; Yilmaz, D1
Aguayo, C; Avila, P; Cabrera, L; Gallardo, V; González, M; Guzmán-Gutiérrez, E; Leiva, A; Palma, C; Pardo, F; Peña, E; Rojas, S; Sáez, T; Salsoso, R; Sanhueza, C; Sobrevia, L; Villalobos, R1
Chen, W; Harbeck, MC; He, D; Peng, H; Xie, L; Zhuang, Y1
Fuenzalida, B; Gutiérrez, J; Leiva, A; Pardo, F; Salomón, C; Sanhueza, C; Sobrevia, L; Toledo, F; Westermeier, F1
Ackerman, HC; Alkaitis, MS1
Gangoda, M; Haque, MM; Ramasamy, S; Stuehr, DJ1
Belfield, G; Lewis, R; Narjes, F; Öberg, L; Ripa, L; Shamovsky, I; Sjö, P; Tyrchan, C1
Aguiar, AS; da Luz Scheffer, D; de Bortoli da Silva, L; de Matos, FJ; de Oliveira, PA; de Paula Martins, R; Gabach, L; Ghersi, M; Ghisoni, K; Lanfumey, L; Latini, A; Mongeau, R; Nesi, RT; Pérez, MF; Pires, ACS; Prediger, RD; Raisman-Vozari, R; Rubiales-Barioglio, S1
Awasthi, D; Chandra, T; Dikshit, M; Jagavelu, K; Kumar, S; Nagarkoti, S; Sadaf, S1
Aschner, JL; Cunningham, G; Dikalova, A; Fike, CD; Kaplowitz, MR; Summar, M1
Fernando, V; Furuta, S; Letson, J; Sharma, V; Walia, Y; Zheng, X1
Albrecht, J; Czarnecka, AM; Milewski, K; Zielińska, M1
Degrush, E; Drachman, D; Gounis, MJ; Henninger, N; Lindsay, C; Shazeeb, MS; Vardar, Z1

Reviews

30 review(s) available for arginine and sapropterin

ArticleYear
Role of tetrahydrobiopterin in cytokine-stimulated metabolism of tryptophan and hydroxylation of arginine.
    Advances in experimental medicine and biology, 1993, Volume: 338

    Topics: Animals; Arginine; Biopterins; Cell Line; Cells, Cultured; Cytokines; Humans; Hydroxylation; Interferon-gamma; Macrophages; Mice; Mice, Inbred C57BL; Models, Biological; Monocytes; Nitric Oxide; Pterins; Skin; Tryptophan; Tumor Necrosis Factor-alpha

1993
Therapeutic strategies for the inhibition of inducible nitric oxide synthase--potential for a novel class of anti-inflammatory agents.
    Cell biology international, 1996, Volume: 20, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Arginine; Biopterins; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glucocorticoids; Humans; Immunosuppressive Agents; Nitric Oxide; Nitric Oxide Synthase; Transcription Factors

1996
Cellular and molecular mechanisms of endothelial cell dysfunction.
    The Journal of clinical investigation, 1997, Nov-01, Volume: 100, Issue:9

    Topics: Arginase; Arginine; Biopterins; Endothelium, Vascular; Humans; NAD; NADP; Nitric Oxide; Nitric Oxide Synthase; Superoxides

1997
Catalysis by nitric oxide synthase.
    Current opinion in chemical biology, 1998, Volume: 2, Issue:5

    Topics: Antioxidants; Arginine; Biopterins; Catalysis; Citrulline; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Heme; Hydrogen Peroxide; Isoenzymes; Nitric Oxide; Nitric Oxide Synthase

1998
A new decoration for nitric oxide synthase - a Zn(Cys)4 site.
    Structure (London, England : 1993), 1999, Apr-15, Volume: 7, Issue:4

    Topics: Animals; Arginine; Binding Sites; Biopterins; Citrulline; Cysteine; Dimerization; Electron Transport; Macromolecular Substances; Models, Molecular; NADP; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Protein Conformation; Zinc

1999
Nitric oxide biosynthesis, nitric oxide synthase inhibitors and arginase competition for L-arginine utilization.
    Cellular and molecular life sciences : CMLS, 1999, Volume: 55, Issue:8-9

    Topics: Animals; Arginase; Arginine; Biopterins; Calcium; Calmodulin; Electron Transport; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Free Radicals; Humans; Isoenzymes; Mice; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase

1999
Tetrahydrobiopterin and endothelial nitric oxide synthase activity.
    Cardiovascular research, 1999, Aug-01, Volume: 43, Issue:2

    Topics: Antioxidants; Arginine; Biopterins; Citrulline; Coronary Vessels; Endothelium, Vascular; Enzyme Activation; Humans; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Vascular Diseases

1999
Enzymatic function of nitric oxide synthases.
    Cardiovascular research, 1999, Aug-15, Volume: 43, Issue:3

    Topics: Animals; Antioxidants; Arginine; Biopterins; Calcium; Calmodulin; Dimerization; Endothelium, Vascular; Enzyme Activation; Heme; Humans; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III

1999
Current strategies and perspectives for correcting endothelial dysfunction in atherosclerosis.
    Journal of cardiovascular pharmacology, 2001, Volume: 38 Suppl 2

    Topics: Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxidants; Arginine; Aspirin; Biopterins; Calcium Channel Blockers; Coronary Artery Disease; Endothelins; Endothelium, Vascular; Folic Acid; Hormone Replacement Therapy; Humans; Nitrates; Nitric Oxide; Nitric Oxide Synthase

2001
[Role of tetrahydrobiopterin in the regulation of activity of human placental nitric oxide synthase in normal and pre-eclamptic pregnancies].
    Orvosi hetilap, 2002, Feb-24, Volume: 143, Issue:8

    Topics: Arginine; Biopterins; Cytosol; Female; Humans; Nitric Oxide Synthase; Placenta; Pre-Eclampsia; Pregnancy

2002
Pathogenic theories and intrathecal analysis of the sporadic form of Alzheimer's disease.
    Progress in neurobiology, 2002, Volume: 66, Issue:3

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Arginine; Biopterins; Brain; Brain Chemistry; Calcium; Cerebrospinal Fluid; Cerebrospinal Fluid Proteins; Humans; Inflammation; Isoenzymes; Models, Biological; Nerve Degeneration; Nerve Growth Factors; Nerve Tissue Proteins; Neurofibrillary Tangles; Nitric Oxide Synthase; Oxidative Stress; Peroxynitrous Acid; Phosphorylation; Protein Processing, Post-Translational; Synaptic Transmission; tau Proteins

2002
Oxidation of N-hydroxyguanidines by cytochromes P450 and NO-synthases and formation of nitric oxide.
    Drug metabolism reviews, 2002, Volume: 34, Issue:3

    Topics: Arginine; Biopterins; Cytochrome P-450 Enzyme System; Guanidines; Hydroxylamines; Nitric Oxide; Nitric Oxide Synthase; Nitrogen; Oxidation-Reduction; Substrate Specificity

2002
[Structure-function relationships of NO synthase: electron transfer reaction].
    Seikagaku. The Journal of Japanese Biochemical Society, 2003, Volume: 75, Issue:5

    Topics: Animals; Arginine; Binding Sites; Biopterins; Calmodulin; Crystallization; Electron Transport; Heme; Humans; Iron; Nitric Oxide; Nitric Oxide Synthase; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Structure-Activity Relationship; Sulfhydryl Compounds

2003
[Involvement of homocysteine in the pathogenesis of hypertension and hypertensive target-organ damage].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 3

    Topics: Arginine; Arteriosclerosis; Biopterins; Cell Division; Endothelium, Vascular; Folic Acid; Homocysteine; Humans; Hypertension; Insulin Resistance; Muscle, Smooth, Vascular; Nitric Oxide; Oxidative Stress; Risk Factors

2004
[NO and hypertension].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 3

    Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Arginine; Arteriosclerosis; Biopterins; C-Reactive Protein; Endothelium, Vascular; Humans; Hypertension; Mutation; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Perindopril; Reactive Oxygen Species; Vasodilation

2004
Biology and chemistry of the inhibition of nitric oxide synthases by pteridine-derivatives as therapeutic agents.
    Medicinal research reviews, 2004, Volume: 24, Issue:5

    Topics: Animals; Arginine; Binding Sites; Biopterins; Brain Ischemia; Enzyme Inhibitors; Humans; Inflammation; Isoenzymes; Neurodegenerative Diseases; Nitric Oxide Synthase; Protein Conformation; Pteridines; Quantitative Structure-Activity Relationship; Sepsis; Structure-Activity Relationship

2004
Endothelial dysfunction in heart failure: mechanisms and therapeutic approaches.
    Current vascular pharmacology, 2004, Volume: 2, Issue:2

    Topics: Animals; Antioxidants; Arginine; Biopterins; Disease Models, Animal; Endothelins; Endothelium, Vascular; Exercise; Genetic Therapy; Heart Failure; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Renin-Angiotensin System

2004
[Mechanisms of nitric oxide production].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 9

    Topics: Arginine; Biopterins; Calcium; Calmodulin; Cyclic GMP; Guanylate Cyclase; Humans; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Phosphorylation; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Transcription, Genetic

2004
High-pressure studies of the reaction mechanism of nitric-oxide synthase.
    Biochimica et biophysica acta, 2006, Volume: 1764, Issue:3

    Topics: Animals; Arginine; Biopterins; Catalysis; Humans; Nitric Oxide; Nitric Oxide Synthase; Pressure; Temperature

2006
Protection of endothelial function: targets for nutritional and pharmacological interventions.
    Journal of cardiovascular pharmacology, 2006, Volume: 47 Suppl 2

    Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Arginine; Atherosclerosis; Biopterins; Cacao; Calcium Channel Blockers; Cyclooxygenase Inhibitors; Dyslipidemias; Endothelin-1; Endothelins; Endothelium, Vascular; Flavonoids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipoproteins, HDL; Nitric Oxide; Oxidative Stress; Reactive Oxygen Species

2006
Microvascular function and ageing L-arginine, tetrahydrobiopterin and the search for the fountain of vascular youth.
    The Journal of physiology, 2008, Apr-15, Volume: 586, Issue:8

    Topics: Aging; Animals; Arginine; Arterioles; Biopterins; Endothelium, Vascular; Muscle, Skeletal; Rats; Vasodilation

2008
Regulation of nitric oxide production in health and disease.
    Current opinion in clinical nutrition and metabolic care, 2010, Volume: 13, Issue:1

    Topics: Animals; Arginase; Arginine; Ascorbic Acid; Biopterins; Citrulline; Diet; Dietary Fats; Endothelium; Humans; Hypertension; Mice; Nitric Oxide; Nitric Oxide Synthase Type III; Sepsis

2010
Nitric oxide and oxidative stress in vascular disease.
    Pflugers Archiv : European journal of physiology, 2010, Volume: 459, Issue:6

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxidants; Arginine; Aryldialkylphosphatase; Biopterins; Calcium; Cardiovascular Diseases; Catalase; Electron Transport; Glutathione Peroxidase; Heme Oxygenase (Decyclizing); Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mitochondria; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphorylation; Protein Multimerization; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Risk Factors; Superoxide Dismutase; Superoxides; Thioredoxins; Vascular Diseases; Xanthine Oxidase

2010
Nitric oxide pathway in hypertrophied heart: new therapeutic uses of nitric oxide donors.
    Journal of hypertension, 2010, Volume: 28 Suppl 1

    Topics: Arginine; Biopterins; Cardiomegaly; Cyclic GMP; Humans; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase

2010
Pathogenetic role of eNOS uncoupling in cardiopulmonary disorders.
    Free radical biology & medicine, 2011, Apr-01, Volume: 50, Issue:7

    Topics: Arginine; Atherosclerosis; Biopterins; Blood Pressure; Cardiac Surgical Procedures; Cell Adhesion; Endothelium, Vascular; Folic Acid; Humans; Hypertension, Pulmonary; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Oxidation-Reduction; Oxygen; Reactive Oxygen Species; Vasodilation; Ventricular Remodeling

2011
Nitric oxide synthases: regulation and function.
    European heart journal, 2012, Volume: 33, Issue:7

    Topics: Animals; Arginine; Biopterins; Cardiovascular Agents; Cardiovascular Diseases; Endothelium, Vascular; Genetic Therapy; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isoenzymes; Mice; Neovascularization, Physiologic; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III

2012
L-arginine, tetrahydrobiopterin, nitric oxide and diabetes.
    Current opinion in clinical nutrition and metabolic care, 2013, Volume: 16, Issue:1

    Topics: Arginine; Biomarkers; Biopterins; Cardiovascular Diseases; Diabetes Mellitus; Endothelium, Vascular; Homeostasis; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Tetrahydrofolate Dehydrogenase

2013
Tetrahydrobiopterin in nitric oxide synthase.
    IUBMB life, 2013, Volume: 65, Issue:4

    Topics: Amino Acid Oxidoreductases; Arginine; Biopterins; Catalysis; Heme; Nitric Oxide; Nitric Oxide Synthase

2013
Arginine and nitric oxide synthase: regulatory mechanisms and cardiovascular aspects.
    Molecular nutrition & food research, 2014, Volume: 58, Issue:1

    Topics: Adipose Tissue; Arginine; Biological Transport; Biopterins; Cardiovascular Diseases; Cardiovascular System; Citrulline; Diet; Dietary Supplements; Humans; Nitric Oxide Synthase

2014
Role for Tetrahydrobiopterin in the Fetoplacental Endothelial Dysfunction in Maternal Supraphysiological Hypercholesterolemia.
    Oxidative medicine and cellular longevity, 2015, Volume: 2015

    Topics: Animals; Arginine; Biopterins; Borohydrides; Cholesterol; Endothelium, Vascular; Female; Humans; Hypercholesterolemia; Nitric Oxide; Nitric Oxide Synthase Type III; Pregnancy

2015

Trials

3 trial(s) available for arginine and sapropterin

ArticleYear
Tetrahydrobiopterin restores endothelial function in hypercholesterolemia.
    The Journal of clinical investigation, 1997, Jan-01, Volume: 99, Issue:1

    Topics: Adult; Antioxidants; Arginine; Biopterins; Endothelium; Female; Forearm; Humans; Hypercholesterolemia; Male; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Plethysmography; Serotonin; Vasoconstriction; Vasodilation

1997
L-arginine and tetrahydrobiopterin protects against ischemia/reperfusion-induced endothelial dysfunction in patients with type 2 diabetes mellitus and coronary artery disease.
    Atherosclerosis, 2009, Volume: 204, Issue:1

    Topics: Aged; Arginine; Biopterins; Blood Flow Velocity; Cardiovascular Agents; Coronary Artery Disease; Cross-Over Studies; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Therapy, Combination; Endothelium, Vascular; Female; Forearm; Humans; Infusions, Intra-Arterial; Male; Regional Blood Flow; Reperfusion Injury; Treatment Outcome; Vasodilation; Vasodilator Agents

2009
Acute localized administration of tetrahydrobiopterin and chronic systemic atorvastatin treatment restore cutaneous microvascular function in hypercholesterolaemic humans.
    The Journal of physiology, 2011, Oct-01, Volume: 589, Issue:Pt 19

    Topics: Anticholesteremic Agents; Arginase; Arginine; Atorvastatin; Biopterins; Cholesterol; Female; Heating; Heptanoic Acids; Humans; Hypercholesterolemia; Lipoproteins, LDL; Male; Microcirculation; Microdialysis; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Pyrroles; Regional Blood Flow; Skin; Vasodilation

2011

Other Studies

197 other study(ies) available for arginine and sapropterin

ArticleYear
Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle.
    The Journal of biological chemistry, 1992, Dec-25, Volume: 267, Issue:36

    Topics: Amino Acid Oxidoreductases; Animals; Aorta; Arginine; Biopterins; Cells, Cultured; Cytosol; Hypoxanthines; Interferon-gamma; Kinetics; Lipopolysaccharides; Male; Methotrexate; Muscle, Smooth, Vascular; Myoglobin; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Oxidation-Reduction; Oxygen Consumption; Pteridines; Pterins; Rats; Rats, Inbred F344; Recombinant Proteins

1992
Pterins inhibit nitric oxide synthase activity in rat alveolar macrophages.
    British journal of pharmacology, 1992, Volume: 107, Issue:4

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Cells, Cultured; Citrulline; Hypoxanthines; Interferon-gamma; Macrophages, Alveolar; Male; Nitric Oxide Synthase; Nitrites; Pteridines; Pterins; Rats; Rats, Wistar; Recombinant Proteins

1992
Nitric oxide synthase-catalyzed activation of oxygen and reduction of cytochromes: reaction mechanisms and possible physiological implications.
    Journal of cardiovascular pharmacology, 1992, Volume: 20 Suppl 12

    Topics: Amino Acid Oxidoreductases; Arginine; Biopterins; Cerebellum; Cytochrome c Group; Electron Transport; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Hydrogen Peroxide; NADH Dehydrogenase; NADP; Nitric Oxide Synthase; Oxidation-Reduction; Oxygen

1992
Tetrahydrobiopterin induces vasodilation via enhancement of cGMP level.
    European journal of pharmacology, 1992, May-14, Volume: 215, Issue:2-3

    Topics: Animals; Aorta, Thoracic; Arginine; Biopterins; Cyclic GMP; In Vitro Techniques; Methoxamine; Muscle Contraction; NG-Nitroarginine Methyl Ester; Radioimmunoassay; Rats; Vasodilation

1992
(6R)-5,6,7,8-tetrahydro-L-biopterin modulates nitric oxide-associated soluble guanylate cyclase activity in the rat cerebellum.
    Archives of biochemistry and biophysics, 1992, Nov-01, Volume: 298, Issue:2

    Topics: Animals; Arginine; Biopterins; Calcium; Calmodulin; Cerebellum; Cytosol; Guanylate Cyclase; Kinetics; Male; NADP; Nitric Oxide; Nitroprusside; Rats; Rats, Wistar

1992
Ca2+/calmodulin-dependent formation of hydrogen peroxide by brain nitric oxide synthase.
    The Biochemical journal, 1992, Feb-01, Volume: 281 ( Pt 3)

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Binding, Competitive; Biopterins; Brain; Calcium; Calmodulin; Citrulline; Hydrogen Peroxide; NADP; Nitric Oxide Synthase; Nitroarginine; omega-N-Methylarginine; Swine

1992
Identification and characterization of a calmodulin-dependent nitric oxide synthase from GH3 pituitary cells.
    The Biochemical journal, 1992, Jul-01, Volume: 285 ( Pt 1)

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Autoradiography; Biopterins; Blotting, Western; Brain; Calmodulin; Cattle; Cells, Cultured; Chromatography, DEAE-Cellulose; Citrulline; Enzyme Activation; Kinetics; NADH Dehydrogenase; Nitric Oxide Synthase; Nitroarginine; Nitroblue Tetrazolium; omega-N-Methylarginine; Pituitary Gland

1992
Inducible but not constitutive production of nitric oxide by vascular smooth muscle cells.
    European journal of pharmacology, 1991, Aug-06, Volume: 200, Issue:2-3

    Topics: Animals; Arginine; Biopterins; Calcium; Calmodulin; Cells, Cultured; Cyclic CMP; Lipopolysaccharides; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats

1991
Induction of nitric oxide synthase by cytokines in vascular smooth muscle cells.
    FEBS letters, 1990, Nov-26, Volume: 275, Issue:1-2

    Topics: Amino Acid Oxidoreductases; Animals; Aorta, Thoracic; Arginine; Biopterins; Cells, Cultured; Cyclic GMP; Cytokines; Enzyme Induction; In Vitro Techniques; Interferon-gamma; Interleukin-1; Muscle, Smooth, Vascular; NADP; Nitric Oxide; Nitric Oxide Synthase; Rabbits; Tumor Necrosis Factor-alpha

1990
Tetrahydrobiopterin, a cofactor for rat cerebellar nitric oxide synthase, does not function as a reactant in the oxygenation of arginine.
    Proceedings of the National Academy of Sciences of the United States of America, 1991, Aug-15, Volume: 88, Issue:16

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Cerebellum; Chromatography, Affinity; Chromatography, Ion Exchange; Kinetics; Male; Methotrexate; Nitric Oxide Synthase; Protein Binding; Rats; Rats, Inbred Strains

1991
Cytokine-activated endothelial cells express an isotype of nitric oxide synthase which is tetrahydrobiopterin-dependent, calmodulin-independent and inhibited by arginine analogs with a rank-order of potency characteristic of activated macrophages.
    Biochemical and biophysical research communications, 1991, Aug-15, Volume: 178, Issue:3

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Brain; Calmodulin; Cells, Cultured; Cycloheximide; Cytokines; Endothelium, Vascular; Interferon-gamma; Isoenzymes; Kinetics; Macrophage Activation; Macrophages; Mice; Nitric Oxide; Nitric Oxide Synthase; Pteridines; Pterins; Recombinant Proteins; Tumor Necrosis Factor-alpha

1991
Brain nitric oxide synthase is a biopterin- and flavin-containing multi-functional oxido-reductase.
    FEBS letters, 1991, Aug-19, Volume: 288, Issue:1-2

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Calcium; Calmodulin; Cerebellum; Citrulline; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Hydrogen Peroxide; Kinetics; NADP; Nitric Oxide; Nitric Oxide Synthase; Spectrophotometry; Swine

1991
Characterization of nitric oxide synthases in non-adrenergic non-cholinergic nerve containing tissue from the rat anococcygeus muscle.
    British journal of pharmacology, 1991, Volume: 104, Issue:2

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Calcium; Citrulline; Endothelium, Vascular; In Vitro Techniques; Male; Muscles; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Inbred Strains; Vas Deferens

1991
Macrophage oxidation of L-arginine to nitric oxide, nitrite, and nitrate. Tetrahydrobiopterin is required as a cofactor.
    The Journal of biological chemistry, 1989, Nov-25, Volume: 264, Issue:33

    Topics: Animals; Arginine; Biopterins; Cell Line; Chromatography, High Pressure Liquid; Citrulline; Cytosol; Kinetics; Macrophages; NADP; Nitrates; Nitric Oxide; Nitrites; Oxidation-Reduction

1989
Inducible nitric oxide synthase activity in hepatocytes is dependent on the coinduction of tetrahydrobiopterin synthesis.
    Advances in experimental medicine and biology, 1993, Volume: 338

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Cells, Cultured; Cytokines; Enzyme Induction; Gene Expression; GTP Cyclohydrolase; Hypoxanthines; Lipopolysaccharides; Liver; Methotrexate; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; RNA, Messenger

1993
Nitric oxide inhibits neuronal nitric oxide synthase by interacting with the heme prosthetic group. Role of tetrahydrobiopterin in modulating the inhibitory action of nitric oxide.
    The Journal of biological chemistry, 1994, Aug-26, Volume: 269, Issue:34

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Carbon Monoxide; Cerebellum; Citrulline; Cyanides; Heme; NADP; Neurons; Nitric Oxide; Nitric Oxide Synthase; Oxidants; Oxyhemoglobins; Rats; Sulfhydryl Compounds; Superoxide Dismutase

1994
Identification of imidazole as L-arginine-competitive inhibitor of porcine brain nitric oxide synthase.
    FEBS letters, 1994, Aug-22, Volume: 350, Issue:2-3

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Binding Sites; Binding, Competitive; Biopterins; Brain; Imidazoles; In Vitro Techniques; Nitric Oxide Synthase; Swine

1994
Hepatocyte inducible nitric oxide synthesis is influenced in vitro by cell density.
    The American journal of physiology, 1994, Volume: 267, Issue:2 Pt 1

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Cell Count; Cells, Cultured; Cyclic GMP; Cytokines; Humans; Lipopolysaccharides; Liver; Male; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; RNA, Messenger

1994
A bacterial nitric oxide synthase from a Nocardia species.
    Biochemical and biophysical research communications, 1994, Sep-15, Volume: 203, Issue:2

    Topics: Amino Acid Oxidoreductases; Arginine; Biopterins; Calcium; Citrulline; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; NADP; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nocardia; Oxygen

1994
Stimulation of IRE-BP activity of IRF by tetrahydrobiopterin and cytokine dependent induction of nitric oxide synthase.
    Advances in experimental medicine and biology, 1994, Volume: 356

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Cell Line; Chloramphenicol O-Acetyltransferase; Deferoxamine; Humans; Interferon-gamma; Iron; Iron-Regulatory Proteins; Kinetics; Leukemia, Myeloid, Acute; Lipopolysaccharides; Macrophages; Mice; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; RNA Probes; RNA-Binding Proteins; Transfection; Tumor Cells, Cultured

1994
N-nitro-L-arginine and N-monomethyl-L-arginine exhibit a different pattern of inactivation toward the three nitric oxide synthases.
    Archives of biochemistry and biophysics, 1995, Jun-20, Volume: 320, Issue:1

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Binding Sites; Biopterins; Brain; In Vitro Techniques; Isoenzymes; Kinetics; Male; Models, Biological; Nitric Oxide Synthase; Nitroarginine; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley

1995
Tetrahydrobiopterin deficiency and brain nitric oxide synthase in the hph1 mouse.
    Journal of inherited metabolic disease, 1995, Volume: 18, Issue:1

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Brain; GTP Cyclohydrolase; Kinetics; Metabolism, Inborn Errors; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mutation; Nitric Oxide Synthase

1995
Structural analysis of porcine brain nitric oxide synthase reveals a role for tetrahydrobiopterin and L-arginine in the formation of an SDS-resistant dimer.
    The EMBO journal, 1995, Aug-01, Volume: 14, Issue:15

    Topics: Allosteric Regulation; Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Brain Chemistry; Hot Temperature; Neurons; Nitric Oxide Synthase; Protein Conformation; Protein Folding; Protein Structure, Secondary; Sodium Dodecyl Sulfate; Swine

1995
Thiol dependence of nitric oxide synthase.
    Biochemistry, 1995, Oct-17, Volume: 34, Issue:41

    Topics: Animals; Arginine; Biopterins; Cerebellum; Citrulline; Kinetics; NADP; Nitric Oxide Synthase; Rats; Structure-Activity Relationship; Sulfhydryl Compounds; Swine

1995
Regulation of the L-arginine-dependent and tetrahydrobiopterin-dependent biosynthesis of nitric oxide in murine macrophages.
    European journal of biochemistry, 1993, Apr-15, Volume: 213, Issue:2

    Topics: Alcohol Oxidoreductases; Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Cells, Cultured; Cytosol; Dexamethasone; GTP Cyclohydrolase; Hypoxanthines; Macrophages; Mice; Mice, Inbred C3H; Nitric Oxide; Nitric Oxide Synthase; Phenprocoumon

1993
Multiple catalytic functions of brain nitric oxide synthase. Biochemical characterization, cofactor-requirement, and the role of N omega-hydroxy-L-arginine as an intermediate.
    The Journal of biological chemistry, 1993, Jul-15, Volume: 268, Issue:20

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Brain; Catalysis; Coenzymes; Heme; Hydrolysis; Kinetics; NADP; Nitric Oxide Synthase; Oxidation-Reduction; Substrate Specificity; Swine

1993
Tetrahydrobiopterin-dependent nitrite oxidation to nitrate in isolated rat hepatocytes.
    FEBS letters, 1993, Oct-18, Volume: 332, Issue:3

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Cells, Cultured; Cytosol; Humans; Interleukin-1; Kinetics; Lipopolysaccharides; Liver; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; omega-N-Methylarginine; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Tumor Necrosis Factor-alpha

1993
Coinduction of nitric oxide synthesis and intracellular nonheme iron-nitrosyl complexes in murine cytokine-treated fibroblasts.
    Free radical biology & medicine, 1994, Volume: 16, Issue:6

    Topics: Animals; Arginine; Biopterins; Cytokines; Electron Spin Resonance Spectroscopy; Escherichia coli; Ferric Compounds; Fibroblasts; Hypoxanthines; Interferon-gamma; Iron; Lipopolysaccharides; Mice; Nitric Oxide; omega-N-Methylarginine; Recombinant Proteins; Tumor Necrosis Factor-alpha

1994
Mutation in the 4a-carbinolamine dehydratase gene leads to mild hyperphenylalaninemia with defective cofactor metabolism.
    American journal of human genetics, 1993, Volume: 53, Issue:3

    Topics: Amino Acid Metabolism, Inborn Errors; Amino Acid Sequence; Arginine; Base Sequence; Biopterins; Cysteine; DNA Mutational Analysis; DNA-Binding Proteins; Gene Expression Regulation, Enzymologic; Hepatocyte Nuclear Factor 1; Hepatocyte Nuclear Factor 1-alpha; Hepatocyte Nuclear Factor 1-beta; Humans; Hydro-Lyases; Infant; Male; Molecular Sequence Data; Nuclear Proteins; Pedigree; Phenylalanine; Phenylketonurias; Point Mutation; Transcription Factors

1993
Conditions required for the measurement of nitric oxide synthase activity in a myenteric plexus/smooth muscle preparation from the rat ileum.
    Journal of neuroscience methods, 1995, Volume: 59, Issue:2

    Topics: Animals; Antioxidants; Arginine; Biopterins; Calcium; Calmodulin; Citrulline; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Ileum; In Vitro Techniques; Muscle, Smooth; Myenteric Plexus; NADP; Nitric Oxide Synthase; Rats; Rats, Wistar

1995
Intracellular assembly of inducible NO synthase is limited by nitric oxide-mediated changes in heme insertion and availability.
    The Journal of biological chemistry, 1996, Mar-08, Volume: 271, Issue:10

    Topics: Aminolevulinic Acid; Animals; Arginine; Biopterins; Cell Line; Cytokines; Enzyme Induction; Enzyme Inhibitors; Heme; Homeostasis; Interferon-gamma; Iron; Isoenzymes; Kinetics; Lipopolysaccharides; Macromolecular Substances; Macrophage Activation; Macrophages; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Recombinant Proteins; Time Factors

1996
Endothelial nitric-oxide synthase. Expression in Escherichia coli, spectroscopic characterization, and role of tetrahydrobiopterin in dimer formation.
    The Journal of biological chemistry, 1996, May-10, Volume: 271, Issue:19

    Topics: Animals; Arginine; Biopterins; Cattle; Chromatography, Affinity; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Heme; Histidine; Kinetics; Macromolecular Substances; Molecular Weight; Nitric Oxide Synthase; Protein Denaturation; Recombinant Proteins; Restriction Mapping; Sequence Tagged Sites; Spectrophotometry; Substrate Specificity

1996
Reduction of quinonoid dihydrobiopterin to tetrahydrobiopterin by nitric oxide synthase.
    The Journal of biological chemistry, 1996, Feb-23, Volume: 271, Issue:8

    Topics: Animals; Arginine; Biopterins; Cell Line; Cerebellum; Enzyme Inhibitors; Humans; Indazoles; Kidney; Kinetics; Methotrexate; NADP; Nitric Oxide Synthase; Nitroarginine; Onium Compounds; Oxidation-Reduction; Rats; Recombinant Proteins; Transfection

1996
Characterization of heme-deficient neuronal nitric-oxide synthase reveals a role for heme in subunit dimerization and binding of the amino acid substrate and tetrahydrobiopterin.
    The Journal of biological chemistry, 1996, Mar-29, Volume: 271, Issue:13

    Topics: Animals; Arginine; Binding Sites; Biopterins; Brain; Chromatography, Gel; Circular Dichroism; Citrulline; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Heme; Isoenzymes; Light; Macromolecular Substances; Neurons; Nitric Oxide Synthase; Nitroarginine; Protein Conformation; Protein Structure, Secondary; Rats; Scattering, Radiation; Thermodynamics

1996
Identification of the domains of neuronal nitric oxide synthase by limited proteolysis.
    The Biochemical journal, 1996, Feb-15, Volume: 314 ( Pt 1)

    Topics: Amino Acid Sequence; Animals; Arginine; Binding Sites; Biopterins; Blotting, Western; Brain; Calmodulin; Chymotrypsin; Cytochrome c Group; Electrophoresis, Polyacrylamide Gel; Flavin Mononucleotide; Heme; Humans; Molecular Sequence Data; Molecular Weight; Nitric Oxide Synthase; Nitroarginine; Peptide Fragments; Rabbits; Rats; Recombinant Proteins; Trypsin

1996
Role of tetrahydrobiopterin availability in the regulation of nitric-oxide synthase expression in human mesangial cells.
    The Journal of biological chemistry, 1996, Jun-14, Volume: 271, Issue:24

    Topics: Arginine; Biopterins; Cells, Cultured; Enzyme Induction; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glomerular Mesangium; Humans; Interleukin-1; Kinetics; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitrites; Nitroprusside; Pteridines; Pterins; Recombinant Proteins; RNA, Messenger; Sugar Acids; Transcription, Genetic; Tumor Necrosis Factor-alpha

1996
Overexpression of neuronal nitric oxide synthase in insect cells reveals requirement of haem for tetrahydrobiopterin binding.
    The Biochemical journal, 1996, Apr-01, Volume: 315 ( Pt 1)

    Topics: Animals; Arginine; Baculoviridae; Biopterins; Brain; Citrulline; Culture Media; Flavins; Heme; Kinetics; Neurons; Nitric Oxide Synthase; Protein Processing, Post-Translational; Rats; Recombinant Proteins; Spodoptera; Tritium

1996
Calcium-dependent nitric oxide synthesis is potently stimulated by tetrahydrobiopterin in human primordial placenta.
    Placenta, 1996, Volume: 17, Issue:1

    Topics: Arginine; Biopterins; Calcium; Citrulline; Enzyme Activation; Female; Humans; NADP; Nitric Oxide; Nitric Oxide Synthase; Placenta; Pregnancy

1996
Active-site structure analysis of recombinant human inducible nitric oxide synthase using imidazole.
    Biochemistry, 1996, Jul-23, Volume: 35, Issue:29

    Topics: Arginine; Binding Sites; Biopterins; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Imidazoles; Isoenzymes; Kinetics; Molecular Structure; Nitric Oxide Synthase; Nitroarginine; Recombinant Proteins; Spectrophotometry; Structure-Activity Relationship

1996
Glucocorticoids regulate inducible nitric oxide synthase by inhibiting tetrahydrobiopterin synthesis and L-arginine transport.
    The Journal of biological chemistry, 1996, Sep-27, Volume: 271, Issue:39

    Topics: Animals; Arginine; Argininosuccinate Lyase; Argininosuccinate Synthase; Biological Transport; Biopterins; Cells, Cultured; Cytokines; Dexamethasone; Gene Expression Regulation, Enzymologic; Glucocorticoids; GTP Cyclohydrolase; Interferon-gamma; Interleukin-1; Male; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Rats; Rats, Sprague-Dawley; Recombinant Proteins

1996
Nitrite generation in interleukin-4-treated human macrophage cultures does not involve the nitric oxide synthase pathway.
    The Journal of infectious diseases, 1997, Volume: 175, Issue:1

    Topics: Amino Acids; Animals; Arginine; Biopterins; Cells, Cultured; Culture Media; Female; Humans; Interferon-gamma; Interleukin-4; Macrophages; Male; Muscle, Smooth, Vascular; Neopterin; Nitrates; Nitric Oxide Synthase; Nitrites; Oxidation-Reduction; Rats; Recombinant Proteins

1997
Subunit interactions of endothelial nitric-oxide synthase. Comparisons to the neuronal and inducible nitric-oxide synthase isoforms.
    The Journal of biological chemistry, 1997, Jan-10, Volume: 272, Issue:2

    Topics: Antioxidants; Arginine; Biopterins; Endothelium, Vascular; Enzyme Induction; Humans; Isoenzymes; Neurons; Nitric Oxide Synthase; Protein Conformation

1997
Active site topologies and cofactor-mediated conformational changes of nitric-oxide synthases.
    The Journal of biological chemistry, 1997, Mar-07, Volume: 272, Issue:10

    Topics: Animals; Arginine; Binding Sites; Biopterins; Calmodulin; Cattle; Imides; Imines; Iron; Nitric Oxide Synthase; Protein Conformation; Rats

1997
Thiols and neuronal nitric oxide synthase: complex formation, competitive inhibition, and enzyme stabilization.
    Biochemistry, 1997, Apr-08, Volume: 36, Issue:14

    Topics: Animals; Arginine; Biopterins; Calmodulin; Cysteine; Dithiothreitol; Enzyme Inhibitors; Enzyme Stability; Flavin-Adenine Dinucleotide; Heme; Mercaptoethanol; NADP; Neurons; Nitric Oxide Synthase; Protein Binding; Rats; Spectrometry, Fluorescence; Spectrophotometry; Sulfhydryl Compounds; Temperature

1997
Mutagenesis of acidic residues in the oxygenase domain of inducible nitric-oxide synthase identifies a glutamate involved in arginine binding.
    Biochemistry, 1997, Apr-29, Volume: 36, Issue:17

    Topics: Alanine; Amino Acid Sequence; Animals; Antioxidants; Arginine; Biopterins; Cattle; Chromatography, Gel; Glutamic Acid; Heme; Humans; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Nitric Oxide Synthase; Oxygenases; Rats; Structure-Activity Relationship

1997
Delineation of the arginine- and tetrahydrobiopterin-binding sites of neuronal nitric oxide synthase.
    The Biochemical journal, 1997, Apr-01, Volume: 323 ( Pt 1)

    Topics: Amino Acid Sequence; Animals; Antioxidants; Arginine; Binding Sites; Biopterins; Calorimetry; Escherichia coli; Heme; Humans; Mice; Molecular Sequence Data; Neurons; Nitric Oxide Synthase; Peptide Mapping; Rats; Sequence Alignment; Structure-Activity Relationship

1997
The ferrous-dioxy complex of neuronal nitric oxide synthase. Divergent effects of L-arginine and tetrahydrobiopterin on its stability.
    The Journal of biological chemistry, 1997, Jul-11, Volume: 272, Issue:28

    Topics: Animals; Arginine; Biopterins; Catalysis; Enzyme Stability; Ferrous Compounds; Heme; Models, Chemical; Neurons; Nitric Oxide Synthase; Oxygen; Rats; Spectrophotometry, Atomic

1997
Regulation of cerebellar nitric oxide production in response to prolonged in vivo hypoxia.
    Journal of neuroscience research, 1997, Jul-01, Volume: 49, Issue:1

    Topics: Animals; Arginine; Argininosuccinate Lyase; Biopterins; Cerebellum; Citrulline; Endothelium, Vascular; Enzyme Induction; GTP Cyclohydrolase; Hypoxia, Brain; Isoenzymes; Male; Nerve Tissue Proteins; Neurons; Nitric Oxide; Nitric Oxide Synthase; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; RNA, Messenger

1997
Endothelial nitric oxide synthase: modulations of the distal heme site produced by progressive N-terminal deletions.
    Biochemistry, 1997, Jul-15, Volume: 36, Issue:28

    Topics: Amino Acid Sequence; Animals; Arginine; Biopterins; Catalysis; Cattle; Chromatography, Gel; Cloning, Molecular; Dimerization; Electrophoresis, Polyacrylamide Gel; Endothelium; Molecular Sequence Data; Nitric Oxide Synthase; Protein Binding; Recombinant Proteins; Sequence Alignment; Sequence Deletion; Spectrophotometry; Spectrum Analysis, Raman

1997
Tetrahydrobiopterin regulates cyclic GMP-dependent electrogenic Cl- secretion in mouse ileum in vitro.
    The Journal of physiology, 1997, Sep-01, Volume: 503 ( Pt 2)

    Topics: Animals; Antioxidants; Arginine; Biopterins; Carbachol; Chloride Channels; Cholinergic Agonists; Cyclic GMP; Ileum; In Vitro Techniques; Intestinal Mucosa; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Muscle, Smooth; Nitric Oxide; Nitrites; Time Factors

1997
The structure of nitric oxide synthase oxygenase domain and inhibitor complexes.
    Science (New York, N.Y.), 1997, Oct-17, Volume: 278, Issue:5337

    Topics: Amino Acid Sequence; Arginine; Binding Sites; Biopterins; Caenorhabditis elegans Proteins; Catalysis; Crystallography, X-Ray; Dimerization; Enzyme Induction; Enzyme Inhibitors; Guanidines; Heme; Homeodomain Proteins; Hydrogen Bonding; Imidazoles; Isoenzymes; Models, Molecular; Molecular Sequence Data; Nitric Oxide Synthase; Oxidation-Reduction; Oxygen; Oxygenases; Protein Conformation; Protein Folding; Protein Structure, Secondary

1997
Electron transfer and catalytic activity of nitric oxide synthases. Chimeric constructs of the neuronal, inducible, and endothelial isoforms.
    The Journal of biological chemistry, 1998, Mar-06, Volume: 273, Issue:10

    Topics: Animals; Arginine; Biopterins; Calmodulin; Cattle; Cytochrome c Group; Dimerization; Egtazic Acid; Electron Transport; Isoenzymes; NADP; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Recombinant Fusion Proteins; Recombinant Proteins; Sequence Homology, Amino Acid

1998
Structure of nitric oxide synthase oxygenase dimer with pterin and substrate.
    Science (New York, N.Y.), 1998, Mar-27, Volume: 279, Issue:5359

    Topics: Animals; Arginine; Binding Sites; Biopterins; Citrulline; Crystallography, X-Ray; Dimerization; Hydrogen Bonding; Isoenzymes; Ligands; Macrophages; Mice; Models, Molecular; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Protein Conformation; Protein Folding; Protein Structure, Secondary; Thiourea

1998
Effects of pH on the structure and function of neuronal nitric oxide synthase.
    The Biochemical journal, 1998, May-01, Volume: 331 ( Pt 3)

    Topics: Animals; Arginine; Biopterins; Brain; Citrulline; Dimerization; Heme; Hydrogen Peroxide; Hydrogen-Ion Concentration; NADP; Nerve Tissue Proteins; Nitric Oxide Synthase; Protein Binding; Protein Conformation; Rats; Spectrophotometry

1998
Nitroarginine and tetrahydrobiopterin binding to the haem domain of neuronal nitric oxide synthase using a scintillation proximity assay.
    The Biochemical journal, 1998, May-15, Volume: 332 ( Pt 1)

    Topics: Animals; Arginine; Binding Sites; Binding, Competitive; Biopterins; Enzyme Inhibitors; Heme; Indazoles; Isothiuronium; Kinetics; Nitric Oxide Synthase; Nitroarginine; Oxidoreductases; Oxygenases; Peptide Fragments; Protein Binding; Rats; Recombinant Fusion Proteins

1998
Reduction by tetrahydrobiopterin of H2O2-induced endothelial cell injury.
    Pharmacology & toxicology, 1998, Volume: 82, Issue:6

    Topics: Animals; Arginine; Biopterins; Cattle; Cells, Cultured; Endothelium, Vascular; Hydrogen Peroxide; Ionomycin; omega-N-Methylarginine; Pteridines; Pterins; Rats; Serotonin

1998
The regulation of dopamine release from striatum slices by tetrahydrobiopterin and L-arginine-derived nitric oxide.
    Brain research, 1998, Aug-03, Volume: 800, Issue:2

    Topics: Animals; Antioxidants; Arginine; Biopterins; Catalase; Corpus Striatum; Diuretics; Dopamine; Ethacrynic Acid; Male; Nitric Oxide; Nitric Oxide Synthase; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Sugar Acids; Superoxide Dismutase; Superoxides; Tritium; Tyrosine 3-Monooxygenase

1998
CO binding studies of nitric oxide synthase: effects of the substrate, inhibitors and tetrahydrobiopterin.
    FEBS letters, 1998, Jul-03, Volume: 430, Issue:3

    Topics: Animals; Arginine; Biopterins; Carbon Monoxide; Enzyme Inhibitors; Kinetics; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Photolysis; Rats; Spectrophotometry

1998
Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors.
    Proceedings of the National Academy of Sciences of the United States of America, 1998, Aug-04, Volume: 95, Issue:16

    Topics: Animals; Arginine; Biopterins; Calcium; Calmodulin; Cattle; Electron Spin Resonance Spectroscopy; NADP; NADPH Oxidases; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Spin Labels; Superoxides

1998
Chiral recognition at the heme active site of nitric oxide synthase is markedly enhanced by L-arginine and 5,6,7,8-tetrahydrobiopterin.
    Biochemical and biophysical research communications, 1998, Jul-30, Volume: 248, Issue:3

    Topics: Anaerobiosis; Animals; Antioxidants; Arginine; Binding Sites; Biopterins; Calmodulin; Cloning, Molecular; Heme; Kinetics; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Recombinant Proteins; Saccharomyces cerevisiae; Spectrophotometry; Stereoisomerism

1998
Superoxide generation from endothelial nitric-oxide synthase. A Ca2+/calmodulin-dependent and tetrahydrobiopterin regulatory process.
    The Journal of biological chemistry, 1998, Oct-02, Volume: 273, Issue:40

    Topics: Arginine; Biopterins; Calcium; Calmodulin; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Free Radicals; Humans; NADP; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Recombinant Proteins; Sodium Cyanide; Spin Labels; Stereoisomerism; Superoxides

1998
Reactions catalyzed by tetrahydrobiopterin-free nitric oxide synthase.
    Biochemistry, 1998, Nov-03, Volume: 37, Issue:44

    Topics: Amino Acids; Animals; Arginine; Biopterins; Carbon Monoxide; Catalase; Catalysis; Chromatography, Gel; Enzyme Induction; Escherichia coli; Macrophages; Mice; NADP; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Recombinant Proteins; Spectrophotometry, Ultraviolet

1998
The C331A mutant of neuronal nitric-oxide synthase is defective in arginine binding.
    The Journal of biological chemistry, 1998, Dec-25, Volume: 273, Issue:52

    Topics: Animals; Arginine; Biopterins; Calmodulin; Carbon Monoxide; Catalytic Domain; Conserved Sequence; Cysteine; Electron Spin Resonance Spectroscopy; Escherichia coli; Heme; Mutation; NADP; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidation-Reduction; Rats; Recombinant Proteins; Spectrophotometry; Structure-Activity Relationship

1998
Sensitivity of flavin fluorescence dynamics in neuronal nitric oxide synthase to cofactor-induced conformational changes and dimerization.
    Biochemistry, 1998, Dec-15, Volume: 37, Issue:50

    Topics: Animals; Arginine; Biopterins; Brain; Calmodulin; Dimerization; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Flavins; Fluorescence Polarization; Heme; Holoenzymes; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Protein Binding; Protein Conformation; Rats; Spectrometry, Fluorescence; Substrate Specificity; Thermodynamics

1998
Autoxidation rates of neuronal nitric oxide synthase: effects of the substrates, inhibitors, and modulators.
    Biochemical and biophysical research communications, 1998, Dec-30, Volume: 253, Issue:3

    Topics: Animals; Arginine; Biopterins; Flow Injection Analysis; Kinetics; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Onium Compounds; Oxidation-Reduction; Rats; Spectrophotometry

1998
Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation.
    Nature structural biology, 1999, Volume: 6, Issue:3

    Topics: Amino Acid Sequence; Animals; Arginine; Binding Sites; Biopterins; Conserved Sequence; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Heme; Humans; Mice; Molecular Sequence Data; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Protein Structure, Secondary; Recombinant Proteins; Sequence Homology, Amino Acid; Substrate Specificity

1999
Stoichiometric arginine binding in the oxygenase domain of inducible nitric oxide synthase requires a single molecule of tetrahydrobiopterin per dimer.
    Biochemical and biophysical research communications, 1999, Apr-13, Volume: 257, Issue:2

    Topics: Animals; Arginine; Binding Sites; Biopterins; Carbon Monoxide; Chromatography, Gel; Conserved Sequence; Dimerization; Dithionite; Ferrous Compounds; Heme; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxygenases; Protein Binding; Recombinant Proteins; Spectrophotometry, Ultraviolet; Titrimetry

1999
Hypoxia inhibits increased ETB receptor-mediated NO synthesis in hypertensive rat lungs.
    The American journal of physiology, 1999, Volume: 276, Issue:4

    Topics: Animals; Arginine; Biopterins; Egtazic Acid; Enzyme Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; In Vitro Techniques; Luminescent Measurements; Lung; Lysine; Male; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; Receptor, Endothelin B; Receptors, Endothelin; Time Factors

1999
Cytokine-induced venodilatation in humans in vivo: eNOS masquerading as iNOS.
    Cardiovascular research, 1999, Volume: 41, Issue:3

    Topics: Adult; Arginine; Biopterins; Bradykinin; Endothelium, Vascular; Enzyme Inhibitors; Female; Gene Expression; Guanidines; Humans; Interleukin-1; Interleukin-6; Intracellular Signaling Peptides and Proteins; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Norepinephrine; omega-N-Methylarginine; Proteins; Reverse Transcriptase Polymerase Chain Reaction; Shock, Septic; Tumor Necrosis Factor-alpha; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents

1999
Geminate recombination of nitric oxide to endothelial nitric-oxide synthase and mechanistic implications.
    The Journal of biological chemistry, 1999, Aug-27, Volume: 274, Issue:35

    Topics: Arginine; Biopterins; Heme; Humans; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Photolysis; Recombinant Proteins; Spectrum Analysis

1999
Tetrahydrobiopterin inhibits monomerization and is consumed during catalysis in neuronal NO synthase.
    The Journal of biological chemistry, 1999, Aug-27, Volume: 274, Issue:35

    Topics: Arginine; Biopterins; Dimerization; Enzyme Stability; Escherichia coli; Humans; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Protein Conformation; Pteridines; Recombinant Proteins; Spectrophotometry; Spermine

1999
Tetrahydrobiopterin-dependent inhibition of superoxide generation from neuronal nitric oxide synthase.
    The Journal of biological chemistry, 1999, Sep-17, Volume: 274, Issue:38

    Topics: Animals; Arginine; Biopterins; Cattle; Citrulline; Electron Spin Resonance Spectroscopy; Models, Chemical; NADP; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxygen; Superoxides

1999
Reactivity of tetrahydrobiopterin bound to nitric-oxide synthase.
    The Journal of biological chemistry, 1999, Oct-15, Volume: 274, Issue:42

    Topics: Animals; Arginine; Biopterins; Cell Line; Humans; Nitric Oxide Synthase; Rats

1999
Presence of excess tetrahydrobiopterin during nitric oxide production from inducible nitric oxide synthase in LPS-treated rat aorta.
    Life sciences, 1999, Volume: 65, Issue:26

    Topics: Animals; Aorta, Thoracic; Arginine; Biopterins; Endothelium, Vascular; Glyceraldehyde-3-Phosphate Dehydrogenases; GTP Cyclohydrolase; Guanidines; Hypoxanthines; In Vitro Techniques; Lipopolysaccharides; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroarginine; Rats; RNA, Messenger

1999
Formation of a pterin radical in the reaction of the heme domain of inducible nitric oxide synthase with oxygen.
    Biochemistry, 1999, Nov-30, Volume: 38, Issue:48

    Topics: Arginine; Biopterins; Electron Spin Resonance Spectroscopy; Free Radicals; Heme; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Oxygen; Pterins

1999
Allosteric regulation of neuronal nitric oxide synthase by tetrahydrobiopterin and suppression of auto-damaging superoxide.
    The Biochemical journal, 2000, Mar-15, Volume: 346 Pt 3

    Topics: Allosteric Regulation; Arginine; Binding Sites; Biopterins; Catalysis; Cell Line; Enzyme Activation; Enzyme Inhibitors; Humans; Indicators and Reagents; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Protein Structure, Quaternary; Superoxides

2000
Ascorbic acid enhances endothelial nitric-oxide synthase activity by increasing intracellular tetrahydrobiopterin.
    The Journal of biological chemistry, 2000, Jun-09, Volume: 275, Issue:23

    Topics: Animals; Aorta; Arginine; Ascorbic Acid; Atrial Natriuretic Factor; Biopterins; Calcimycin; Cattle; Cell Line; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroprusside; Pteridines; Pterins; Recombinant Proteins; Spodoptera; Swine; Transfection

2000
Structures of the N(omega)-hydroxy-L-arginine complex of inducible nitric oxide synthase oxygenase dimer with active and inactive pterins.
    Biochemistry, 2000, Apr-25, Volume: 39, Issue:16

    Topics: Animals; Arginine; Binding Sites; Biopterins; Catalysis; Crystallography, X-Ray; Dimerization; Heme; Hydrogen Bonding; Iron; Mice; Models, Chemical; Models, Molecular; Molecular Sequence Data; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Oxygen; Oxygenases; Protein Conformation; Structure-Activity Relationship

2000
Aromatic residues and neighboring Arg414 in the (6R)-5,6,7, 8-tetrahydro-L-biopterin binding site of full-length neuronal nitric-oxide synthase are crucial in catalysis and heme reduction with NADPH.
    The Journal of biological chemistry, 2000, Aug-25, Volume: 275, Issue:34

    Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Arginine; Binding Sites; Biopterins; Catalysis; Dimerization; Drosophila; Glutamine; Heme; Humans; Hydrogen Bonding; Leucine; Mice; Models, Molecular; Molecular Sequence Data; NADP; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidation-Reduction; Phenylalanine; Rats; Spectrophotometry, Atomic; Structure-Activity Relationship; Tryptophan

2000
Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydrobiopterin deficiency.
    The Biochemical journal, 2000, Jul-01, Volume: 349, Issue:Pt 1

    Topics: Animals; Arginine; Biopterins; Calcium; Calmodulin; Chromatography, High Pressure Liquid; Diabetes Mellitus; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; GTP Cyclohydrolase; Immunoblotting; Kinetics; NADP; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Protein Isoforms; Pteridines; Pterins; Rats; Rats, Mutant Strains

2000
Characterization of interactions among the heme center, tetrahydrobiopterin, and L-arginine binding sites of ferric eNOS using imidazole, cyanide, and nitric oxide as probes.
    Biochemistry, 2000, Aug-08, Volume: 39, Issue:31

    Topics: Animals; Arginine; Binding, Competitive; Biopterins; Catalysis; Cattle; Computer Simulation; Cyanides; Escherichia coli; Ferric Compounds; Flavins; Genetic Vectors; Heme; Humans; Imidazoles; Ligands; Models, Chemical; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Protein Binding

2000
Inhibition of extracellular signal-regulated kinase suppresses endotoxin-induced nitric oxide synthesis in mouse macrophages and in human colon epithelial cells.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 294, Issue:3

    Topics: Animals; Arginine; Biological Transport; Biopterins; Cells, Cultured; Colon; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Humans; Lipopolysaccharides; Macrophages; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II

2000
Arginine conversion to nitroxide by tetrahydrobiopterin-free neuronal nitric-oxide synthase. Implications for mechanism.
    The Journal of biological chemistry, 2000, Oct-27, Volume: 275, Issue:43

    Topics: Arginine; Biopterins; Catalysis; Citrulline; Heme; Hydrogen Peroxide; NADP; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidation-Reduction

2000
FT-Infrared spectroscopic studies of the iron ligand CO stretch mode of iNOS oxygenase domain: effect of arginine and tetrahydrobiopterin.
    Biochemistry, 2000, Aug-22, Volume: 39, Issue:33

    Topics: Animals; Arginine; Biopterins; Carbon Monoxide; Hemeproteins; Mice; Models, Chemical; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Protein Conformation; Recombinant Proteins; Spectroscopy, Fourier Transform Infrared

2000
Low-temperature optical absorption spectra suggest a redox role for tetrahydrobiopterin in both steps of nitric oxide synthase catalysis.
    Biochemistry, 2000, Sep-26, Volume: 39, Issue:38

    Topics: Animals; Arginine; Biopterins; Brain; Catalysis; Dithionite; Ethylene Glycol; Freezing; Isoenzymes; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Oxidation-Reduction; Oxygen; Pterins; Rats; Reducing Agents; Spectrophotometry

2000
Rapid kinetic studies link tetrahydrobiopterin radical formation to heme-dioxy reduction and arginine hydroxylation in inducible nitric-oxide synthase.
    The Journal of biological chemistry, 2001, Jan-05, Volume: 276, Issue:1

    Topics: Animals; Arginine; Biopterins; Catalysis; Enzyme Activation; Free Radicals; Heme; Hydroxylation; Kinetics; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidants; Oxidation-Reduction; Oxygen; Oxygenases; Protein Structure, Tertiary; Recombinant Proteins; Reducing Agents; Spectrophotometry

2001
Modulation of nitric-oxide synthase by nicotine.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:2

    Topics: Animals; Aorta, Thoracic; Arginine; Biopterins; Citrulline; Dogs; Endothelium, Vascular; Flavin-Adenine Dinucleotide; Male; NADP; Nicotine; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Recombinant Proteins

2000
Kinetics of CO and NO ligation with the Cys(331)-->Ala mutant of neuronal nitric-oxide synthase.
    The Journal of biological chemistry, 2001, Feb-16, Volume: 276, Issue:7

    Topics: Animals; Arginine; Biopterins; Carbon Monoxide; Cysteine; Kinetics; Neurons; Nitric Oxide; Nitric Oxide Synthase; Point Mutation; Rats

2001
Endothelial dysfunction in atherosclerotic mice: improved relaxation by combined supplementation with L-arginine-tetrahydrobiopterin and enhanced vasoconstriction by endothelin.
    British journal of pharmacology, 2000, Volume: 131, Issue:7

    Topics: Acetylcholine; Animals; Arginine; Arteriosclerosis; Biopterins; Dietary Supplements; Dose-Response Relationship, Drug; Endothelins; Endothelium, Vascular; Mice; Mice, Inbred C57BL; Nitroprusside; Superoxide Dismutase; Vasoconstriction; Vasodilation

2000
2-thiouracil is a selective inhibitor of neuronal nitric oxide synthase antagonising tetrahydrobiopterin-dependent enzyme activation and dimerisation.
    FEBS letters, 2000, Nov-24, Volume: 485, Issue:2-3

    Topics: Animals; Antithyroid Agents; Arginine; Binding, Competitive; Biopterins; Cerebellum; Citrulline; Cytochrome c Group; Dimerization; Enzyme Activation; Enzyme Inhibitors; Hydrogen Peroxide; Kinetics; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Thiouracil

2000
Paracrine neuroprotective effect of nitric oxide in the developing retina.
    Journal of neurochemistry, 2001, Volume: 76, Issue:4

    Topics: Animals; Animals, Newborn; Anisomycin; Arginine; Biopterins; Cell Death; Cells, Cultured; Cyclic GMP; Guanylate Cyclase; In Vitro Techniques; NADPH Dehydrogenase; Neuroprotective Agents; Nitric Oxide; Paracrine Communication; Penicillamine; Pteridines; Pterins; Rats; Rats, Inbred Strains; Retina; Retinal Ganglion Cells; S-Nitroso-N-Acetylpenicillamine

2001
The optical interconversion of the P-450 and P-420 forms of neuronal nitric oxide synthase: effects of sodium cholate, mercury chloride and urea.
    The international journal of biochemistry & cell biology, 2001, Volume: 33, Issue:2

    Topics: Animals; Arginine; Biopterins; Cysteine; Cytochrome P-450 Enzyme System; Cytochromes; Escherichia coli; Glycerol; Isoenzymes; Mercuric Chloride; Mice; Nitric Oxide Synthase; Plasmids; Sodium Cholate; Spectrophotometry; Transfection; Urea

2001
Oxidations of N(omega)-hydroxyarginine analogues and various N-hydroxyguanidines by NO synthase II: key role of tetrahydrobiopterin in the reaction mechanism and substrate selectivity.
    Chemical research in toxicology, 2001, Volume: 14, Issue:2

    Topics: Antioxidants; Arginine; Biopterins; Guanidines; Hydroxylamines; NADP; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Oxidation-Reduction; Substrate Specificity; Superoxide Dismutase

2001
Hypochlorite-modified low density lipoprotein inhibits nitric oxide synthesis in endothelial cells via an intracellular dislocalization of endothelial nitric-oxide synthase.
    The Journal of biological chemistry, 2001, Apr-27, Volume: 276, Issue:17

    Topics: Antioxidants; Arginine; Biopterins; Blotting, Western; Cell Membrane; Cells, Cultured; Centrifugation, Density Gradient; Citrulline; Cyclic GMP; Cyclodextrins; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Golgi Apparatus; Humans; Hypochlorous Acid; Immunoblotting; Immunohistochemistry; Ionomycin; Ionophores; Lipoproteins, LDL; Microscopy, Fluorescence; Myristic Acids; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Palmitic Acids; Precipitin Tests; RNA, Messenger; Subcellular Fractions; Sucrose; Time Factors; Umbilical Veins

2001
Important role of tetrahydrobiopterin in no complex formation and interdomain electron transfer in neuronal nitric-oxide synthase.
    Biochemical and biophysical research communications, 2001, Apr-20, Volume: 282, Issue:5

    Topics: Anaerobiosis; Animals; Antioxidants; Arginine; Biopterins; Calcium; Calmodulin; Catalysis; Iron; Macromolecular Substances; Models, Chemical; Mutagenesis, Site-Directed; NADP; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidation-Reduction; Rats; Spectrophotometry

2001
Tetrahydrobiopterin augments arginine transport in rat cardiac myocytes through modulation of CAT-2 mRNA.
    The Journal of laboratory and clinical medicine, 2001, Volume: 137, Issue:5

    Topics: Amino Acid Transport Systems, Basic; Animals; Antioxidants; Arginine; Biological Transport; Biopterins; Carrier Proteins; Cells, Cultured; Dose-Response Relationship, Drug; Extracellular Space; Gene Expression Regulation; Lipopolysaccharides; Membrane Proteins; Myocardium; Nitrites; Protein Isoforms; Rats; Rats, Wistar; RNA, Messenger

2001
Inhibition of neuronal nitric oxide synthase by 6-nitrocatecholamines, putative reaction products of nitric oxide with catecholamines under oxidative stress conditions.
    The Biochemical journal, 2001, May-15, Volume: 356, Issue:Pt 1

    Topics: Animals; Arginine; Biopterins; Dopamine; Hydrogen Peroxide; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Norepinephrine; Oxidative Stress; Recombinant Proteins

2001
Tetrahydrobiopterin: a critical cofactor for eNOS and a strategy in the treatment of endothelial dysfunction?
    American journal of physiology. Heart and circulatory physiology, 2001, Volume: 280, Issue:6

    Topics: Animals; Arginine; Biopterins; Cardiovascular Diseases; Clinical Trials as Topic; Coronary Vessels; Dogs; Endothelium, Vascular; Enzyme Inhibitors; Histamine; Humans; Hypercholesterolemia; In Vitro Techniques; Infusions, Intra-Arterial; Ionophores; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Pteridines; Pterins; Reactive Oxygen Species; Species Specificity; Substance P; Swine; Vasoconstrictor Agents; Vasodilator Agents

2001
Tetrahydrobiopterin reverses the inhibition of nitric oxide by high glucose in cultured murine mesangial cells.
    American journal of physiology. Renal physiology, 2001, Volume: 281, Issue:1

    Topics: Animals; Arginine; Ascorbic Acid; Biopterins; Cell Division; Cells, Cultured; Diabetic Nephropathies; Enzyme Induction; Glomerular Mesangium; Glucose; Mice; Models, Chemical; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II

2001
Hypoxia impairs endothelium-dependent relaxation in organ cultured pulmonary artery.
    European journal of pharmacology, 2001, Jun-01, Volume: 421, Issue:1

    Topics: Animals; Arginine; Biopterins; Caveolin 1; Caveolins; Cyclic GMP; Dinoprost; Dose-Response Relationship, Drug; Endothelium, Vascular; Hypoxia; Ionomycin; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroprusside; Organ Culture Techniques; Pulmonary Artery; Rabbits; RNA, Messenger; Substance P; Superoxide Dismutase; Vasoconstriction; Vasodilation; Vasodilator Agents

2001
X-ray absorption spectroscopic analysis of the high-spin ferriheme site in substrate-bound neuronal nitric-oxide synthase.
    Journal of biochemistry, 2001, Volume: 130, Issue:2

    Topics: Animals; Arginine; Biopterins; Catalytic Domain; Cations, Divalent; Copper; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Heme; Humans; Ligands; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Spectrum Analysis; X-Rays

2001
A conserved tryptophan in nitric oxide synthase regulates heme-dioxy reduction by tetrahydrobiopterin.
    Biochemistry, 2001, Oct-30, Volume: 40, Issue:43

    Topics: Animals; Arginine; Biopterins; Conserved Sequence; Electron Spin Resonance Spectroscopy; Electrons; Heme; Kinetics; Light; Mice; Models, Chemical; Mutation; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxygen; Protein Binding; Spectrophotometry; Time Factors; Tryptophan

2001
Carboxy-PTIO increases the tetrahydrobiopterin level in mouse brain microvascular endothelial cells.
    Japanese journal of pharmacology, 2001, Volume: 87, Issue:1

    Topics: Alcohol Oxidoreductases; Animals; Arginine; Benzoates; Biopterins; Brain; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; GTP Cyclohydrolase; Imidazoles; Lipopolysaccharides; Mice; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pterins; RNA, Messenger

2001
Nitric oxide (NO) traffic in endothelial NO synthase. Evidence for a new NO binding site dependent on tetrahydrobiopterin?
    The Journal of biological chemistry, 2002, Mar-01, Volume: 277, Issue:9

    Topics: Arginine; Binding Sites; Biopterins; Dose-Response Relationship, Drug; Heme; Humans; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Protein Binding; Recombinant Proteins; Spectrophotometry; Time Factors

2002
Mechanisms of synergistic cytokine-induced nitric oxide production in human alveolar epithelial cells.
    Nitric oxide : biology and chemistry, 2001, Volume: 5, Issue:6

    Topics: Arginine; Biopterins; Cell Line, Transformed; Cell Nucleus; Cytokines; Epithelial Cells; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Humans; NF-kappa B; Nitric Oxide; Protein Transport; Pulmonary Alveoli

2001
Nitrocatechols versus nitrocatecholamines as novel competitive inhibitors of neuronal nitric oxide synthase: lack of the aminoethyl side chain determines loss of tetrahydrobiopterin-antagonizing properties.
    Bioorganic & medicinal chemistry letters, 2002, Jan-07, Volume: 12, Issue:1

    Topics: Antioxidants; Arginine; Binding Sites; Biopterins; Catecholamines; Catechols; Drug Evaluation, Preclinical; Humans; Inhibitory Concentration 50; Kinetics; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitro Compounds; Protein Isoforms; Structure-Activity Relationship

2002
Impaired endothelial regulation of ventricular relaxation in cardiac hypertrophy: role of reactive oxygen species and NADPH oxidase.
    Circulation, 2001, Dec-11, Volume: 104, Issue:24

    Topics: Animals; Antioxidants; Arginine; Ascorbic Acid; Biopterins; Deferoxamine; Drug Synergism; Endothelium, Vascular; Free Radical Scavengers; Glutathione; Guinea Pigs; Heart Ventricles; Hypertrophy, Left Ventricular; In Vitro Techniques; Male; Malondialdehyde; Metalloporphyrins; Myocardial Contraction; NADPH Oxidases; Oxidation-Reduction; Reactive Oxygen Species; Substance P

2001
Citrulline is not the major product using the standard "NOS activity" assay on renal cortical homogenates.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2002, Volume: 282, Issue:1

    Topics: Animals; Antioxidants; Arginine; Biopterins; Calcium; Carbon Radioisotopes; Chelating Agents; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Citrulline; Egtazic Acid; Enzyme Inhibitors; Female; Guanidines; Humans; Kidney Cortex; Male; Mice; Mice, Inbred Strains; NADP; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; omega-N-Methylarginine; Placenta; Rats; Rats, Long-Evans; Tritium

2002
Cloning, expression, and characterization of a nitric oxide synthase protein from Deinococcus radiodurans.
    Proceedings of the National Academy of Sciences of the United States of America, 2002, Jan-08, Volume: 99, Issue:1

    Topics: Amino Acid Sequence; Animals; Arginine; Biopterins; Catalysis; Citrulline; Cloning, Molecular; Dimerization; Dithiothreitol; Dose-Response Relationship, Drug; Electrons; Heme; Hydrogen Peroxide; Kinetics; Ligands; Models, Chemical; Models, Molecular; Molecular Sequence Data; NADP; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Thermus; Time Factors; Zinc

2002
Direct evidence for nitric oxide production by a nitric-oxide synthase-like protein from Bacillus subtilis.
    The Journal of biological chemistry, 2002, May-03, Volume: 277, Issue:18

    Topics: Amino Acid Sequence; Animals; Arginine; Bacillus subtilis; Bacterial Proteins; Biopterins; Catalysis; Dimerization; Kinetics; Mammals; Molecular Sequence Data; Nitric Oxide; Nitric Oxide Synthase; Protein Structure, Secondary; Sequence Alignment; Sequence Homology, Amino Acid

2002
Reactions catalyzed by the heme domain of inducible nitric oxide synthase: evidence for the involvement of tetrahydrobiopterin in electron transfer.
    Biochemistry, 2002, Mar-12, Volume: 41, Issue:10

    Topics: Arginine; Base Sequence; Biopterins; Catalysis; Chromatography, Gel; DNA Primers; Electron Transport; Heme; Molecular Weight; Nitric Oxide Synthase; Nitric Oxide Synthase Type II

2002
The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study.
    The Biochemical journal, 2002, Mar-15, Volume: 362, Issue:Pt 3

    Topics: Arginine; Biopterins; Electron Spin Resonance Spectroscopy; Endothelium, Vascular; Kinetics; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidation-Reduction; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; Superoxides

2002
Stimulation of tetrahydrobiopterin synthesis by cyclosporin A in mouse brain microvascular endothelial cells.
    The international journal of biochemistry & cell biology, 2002, Volume: 34, Issue:9

    Topics: Animals; Antioxidants; Arginine; Biopterins; Cerebrovascular Circulation; Cycloheximide; Cyclosporine; Endothelium, Vascular; GTP Cyclohydrolase; Immunosuppressive Agents; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Protein Synthesis Inhibitors

2002
Evaluation of basic performance and applicability of a newly developed in vivo nitric oxide sensor.
    Physiological measurement, 2002, Volume: 23, Issue:2

    Topics: Acetylcholine; Animals; Antioxidants; Arginine; Biopterins; Calibration; Electrodes; Enzyme Inhibitors; Equipment Design; Nitric Oxide; Nitric Oxide Synthase; Nitroglycerin; omega-N-Methylarginine; Oxygen; Permeability; Rats; Rats, Inbred WKY; Vasodilator Agents

2002
Binding of L-arginine and imidazole suggests heterogeneity of rat brain neuronal nitric oxide synthase.
    Biochemistry, 2002, Jun-18, Volume: 41, Issue:24

    Topics: Animals; Arginine; Binding, Competitive; Biopterins; Cell Line; Heme; Humans; Imidazoles; Kinetics; Mice; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Spectrophotometry, Ultraviolet; Spodoptera; Titrimetry; Tumor Cells, Cultured

2002
Why do nitric oxide synthases use tetrahydrobiopterin?
    Journal of inorganic biochemistry, 2002, Sep-20, Volume: 91, Issue:4

    Topics: Amino Acid Sequence; Amino Acid Substitution; Arginine; Biopterins; Kinetics; Models, Molecular; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Protein Conformation; Recombinant Proteins

2002
The antithyroid agent 6-n-propyl-2-thiouracil is a mechanism-based inactivator of the neuronal nitric oxide synthase isoform.
    Archives of biochemistry and biophysics, 2002, Nov-01, Volume: 407, Issue:1

    Topics: Animals; Antithyroid Agents; Arginine; Biopterins; Calcium; Calmodulin; Carbon Monoxide; Carbon Radioisotopes; Citrulline; Enzyme Activation; Enzyme Inhibitors; Heme; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pituitary Neoplasms; Propylthiouracil; Rats; Thiouracil; Tumor Cells, Cultured

2002
Structure of tetrahydrobiopterin tunes its electron transfer to the heme-dioxy intermediate in nitric oxide synthase.
    Biochemistry, 2003, Feb-25, Volume: 42, Issue:7

    Topics: Animals; Arginine; Biopterins; Catalysis; Crystallization; Crystallography, X-Ray; Electron Transport; Free Radicals; Heme; Isoenzymes; Kinetics; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Oxygen; Protein Binding; Pterins; Spectrophotometry, Ultraviolet; Structure-Activity Relationship

2003
Induction of LOX-1 and iNOS expressions by ischemia-reperfusion of rat kidney and the opposing effect of L-arginine.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003, Volume: 17, Issue:6

    Topics: Animals; Arginine; Biopterins; Gene Expression Regulation; Kidney; Male; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Rats; Rats, Wistar; Receptors, LDL; Receptors, Oxidized LDL; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Scavenger Receptors, Class E; Superoxide Dismutase; Time Factors

2003
Two modes of binding of N-hydroxyguanidines to NO synthases: first evidence for the formation of iron-N-hydroxyguanidine complexes and key role of tetrahydrobiopterin in determining the binding mode.
    Biochemistry, 2003, Apr-08, Volume: 42, Issue:13

    Topics: Arginine; Binding Sites; Biopterins; Catalysis; Electron Spin Resonance Spectroscopy; Guanidines; Heme; Hydroxylamines; Iron; Kinetics; Ligands; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidation-Reduction; Oxygen; Protein Binding; Spectrum Analysis, Raman; Structure-Activity Relationship

2003
Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through the induction of GTP-cyclohydrolase I and increases nitric oxide synthase activity in vascular endothelial cells.
    Free radical biology & medicine, 2003, May-15, Volume: 34, Issue:10

    Topics: Animals; Arginine; Biopterins; Blotting, Northern; Brain; Cells, Cultured; Citrulline; DNA Primers; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; GTP Cyclohydrolase; Hydrogen Peroxide; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidants; Reverse Transcriptase Polymerase Chain Reaction

2003
Characterization of Drosophila nitric oxide synthase: a biochemical study.
    Biochemical and biophysical research communications, 2003, Jun-27, Volume: 306, Issue:2

    Topics: Animals; Arginine; Biopterins; Dose-Response Relationship, Drug; Drosophila; Electrons; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Heme; Hydrogen Peroxide; Hydrolysis; NADP; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Open Reading Frames; Protein Structure, Tertiary; Spectrophotometry; Time Factors; Trypsin; Ultraviolet Rays; Urea

2003
Effect of tetrahydrobiopterin on blood pressure in rats after subtotal nephrectomy.
    Nephron. Physiology, 2003, Volume: 94, Issue:1

    Topics: Animals; Arginine; Biopterins; Blood Pressure; Creatinine; Hypertension; Kidney; Male; Mesenteric Arteries; Nephrectomy; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Renal Insufficiency

2003
A tetrahydrobiopterin radical forms and then becomes reduced during Nomega-hydroxyarginine oxidation by nitric-oxide synthase.
    The Journal of biological chemistry, 2003, Nov-21, Volume: 278, Issue:47

    Topics: Animals; Arginine; Biopterins; Catalysis; Cloning, Molecular; Electron Spin Resonance Spectroscopy; Free Radicals; Freezing; Kinetics; Mice; Nitric Oxide Synthase; Oxidation-Reduction; Solutions

2003
Ability of tetrahydrobiopterin analogues to support catalysis by inducible nitric oxide synthase: formation of a pterin radical is required for enzyme activity.
    Biochemistry, 2003, Nov-18, Volume: 42, Issue:45

    Topics: Amino Acids; Arginine; Binding Sites; Biopterins; Catalysis; Dithionite; Electron Spin Resonance Spectroscopy; Enzyme Activation; Free Radicals; Freezing; Heme; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Oxyhemoglobins; Protein Structure, Tertiary; Pterins; Recombinant Proteins; Time Factors

2003
Three different oxygen-induced radical species in endothelial nitric-oxide synthase oxygenase domain under regulation by L-arginine and tetrahydrobiopterin.
    The Journal of biological chemistry, 2004, Jul-30, Volume: 279, Issue:31

    Topics: Amino Acids; Arginine; Biopterins; Catalysis; Cytochromes c; Electron Spin Resonance Spectroscopy; Free Radicals; Heme; Humans; Kinetics; Models, Chemical; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Normal Distribution; Oxygen; Oxygenases; Protein Structure, Tertiary; Proteins; Reactive Oxygen Species; Recombinant Proteins; Spectrophotometry; Superoxides; Time Factors

2004
Homocysteine induces oxidative stress by uncoupling of NO synthase activity through reduction of tetrahydrobiopterin.
    Free radical biology & medicine, 2004, Jun-15, Volume: 36, Issue:12

    Topics: Antioxidants; Arginine; Ascorbic Acid; Biopterins; Blotting, Western; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Ethidium; Fluorescent Dyes; Homocysteine; Humans; L-Lactate Dehydrogenase; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphorylation; Pterins; Reactive Nitrogen Species; Superoxides; Thrombin; Time Factors

2004
Synergistic interaction between enalapril, L-arginine and tetrahydrobiopterin in smooth muscle cell apoptosis and aortic remodeling induction in SHR.
    British journal of pharmacology, 2004, Volume: 142, Issue:5

    Topics: Acetylcholine; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta, Thoracic; Apoptosis; Arginine; Biopterins; Blood Pressure; Body Weight; DNA Fragmentation; Drug Synergism; Enalapril; Endothelium, Vascular; In Situ Nick-End Labeling; Male; Muscle, Smooth, Vascular; Nitric Oxide; Rats; Rats, Inbred SHR; Reactive Oxygen Species; Vasodilator Agents

2004
Effect of chronic tetrahydrobiopterin supplementation on blood pressure and proteinuria in 5/6 nephrectomized rats.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2004, Volume: 19, Issue:9

    Topics: Animals; Antihypertensive Agents; Antioxidants; Arginine; Biopterins; Blood Pressure; Diltiazem; Glomerular Mesangium; Hypertension; Kidney Failure, Chronic; Male; Models, Animal; Nephrectomy; Nitric Oxide; Oxidative Stress; Proteinuria; Rats; Rats, Wistar; Vasodilator Agents

2004
Superoxide dismutase and catalase are required to detect (.-)NO from both coupled and uncoupled neuronal no synthase.
    Free radical biology & medicine, 2004, Oct-01, Volume: 37, Issue:7

    Topics: Arginine; Biopterins; Catalase; Electrochemistry; Electrodes; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Humans; Hydrogen Peroxide; Hydroxylation; Luminescent Measurements; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Superoxide Dismutase

2004
Comparison of tetrahydrobiopterin and L-arginine on cerebral blood flow after controlled cortical impact injury in rats.
    Journal of neurotrauma, 2004, Volume: 21, Issue:9

    Topics: Animals; Arginine; Biopterins; Brain Injuries; Cerebral Cortex; Cerebrovascular Circulation; Nitric Oxide; Rats; Rats, Long-Evans

2004
Redox function of tetrahydrobiopterin and effect of L-arginine on oxygen binding in endothelial nitric oxide synthase.
    Biochemistry, 2004, Oct-19, Volume: 43, Issue:41

    Topics: Animals; Arginine; Biopterins; Cattle; Ferric Compounds; Ferrous Compounds; Free Radicals; Heme; Humans; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidation-Reduction; Oxygen; Protein Binding; Protein Structure, Tertiary; Recombinant Proteins; Spodoptera; Two-Hybrid System Techniques

2004
Endogenous methylarginines modulate superoxide as well as nitric oxide generation from neuronal nitric-oxide synthase: differences in the effects of monomethyl- and dimethylarginines in the presence and absence of tetrahydrobiopterin.
    The Journal of biological chemistry, 2005, Mar-04, Volume: 280, Issue:9

    Topics: Animals; Arginine; Biopterins; Calcium; Calmodulin; Cell Line; Citrulline; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Humans; Magnetics; Nitric Oxide Synthase; omega-N-Methylarginine; Oxygen; Rats; Spin Trapping; Superoxides; Time Factors; Transfection

2005
The three nitric-oxide synthases differ in their kinetics of tetrahydrobiopterin radical formation, heme-dioxy reduction, and arginine hydroxylation.
    The Journal of biological chemistry, 2005, Mar-11, Volume: 280, Issue:10

    Topics: Animals; Arginine; Biopterins; Free Radicals; Heme; Humans; Hydroxylation; Kinetics; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidation-Reduction; Rats

2005
A tryptophan that modulates tetrahydrobiopterin-dependent electron transfer in nitric oxide synthase regulates enzyme catalysis by additional mechanisms.
    Biochemistry, 2005, Mar-29, Volume: 44, Issue:12

    Topics: Animals; Arginine; Biopterins; Catalysis; Dimerization; Electron Transport; Enzyme Stability; Ferrous Compounds; Heme; Hydroxylation; Isoenzymes; Kinetics; Mice; Mutagenesis, Site-Directed; NADP; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Oxidation-Reduction; Protein Binding; Rats; Spectrophotometry; Tryptophan

2005
Reductive activation of Cr(Vi) by nitric oxide synthase.
    Chemical research in toxicology, 2005, Volume: 18, Issue:5

    Topics: Animals; Arginine; Biopterins; Brain; Calcium; Calmodulin; Chromates; Chromium; Cytochrome P-450 Enzyme System; Endothelial Cells; Flavins; Hydroxyl Radical; Nitric Oxide Synthase; Oxidation-Reduction; Oxygen; Superoxides; Time Factors

2005
Tetrahydrobiopterin and nitric oxide synthase dimer levels are not changed following hypoxia-ischemia in the newborn rat.
    Brain research. Developmental brain research, 2005, May-12, Volume: 156, Issue:2

    Topics: Analysis of Variance; Animals; Animals, Newborn; Arginine; Biopterins; Blotting, Western; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Electrochemistry; Enzyme Inhibitors; Functional Laterality; Gene Expression Regulation; Hypoxia-Ischemia, Brain; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar; Time Factors

2005
Systemic nitric oxide production rate during hemodialysis and its relationship with nitric oxide-related factors.
    Blood purification, 2005, Volume: 23, Issue:4

    Topics: Arginine; Biopterins; Blood Pressure; Female; Humans; Lipoproteins, LDL; Male; Middle Aged; Nitrates; Nitric Oxide; Renal Dialysis

2005
eNOS function is developmentally regulated: uncoupling of eNOS occurs postnatally.
    American journal of physiology. Lung cellular and molecular physiology, 2006, Volume: 290, Issue:2

    Topics: Aging; Animals; Arginine; Biopterins; Calcimycin; Endothelium, Vascular; Enzyme Activation; Fetus; HSP90 Heat-Shock Proteins; Humans; Nitric Oxide Synthase Type III; Pulmonary Artery; Reactive Oxygen Species; Recombinant Proteins; Sheep; Stress, Mechanical; Superoxides; Vascular Endothelial Growth Factor A; Vasodilation

2006
Hyperhomocystinemia impairs endothelial function and eNOS activity via PKC activation.
    Arteriosclerosis, thrombosis, and vascular biology, 2005, Volume: 25, Issue:12

    Topics: Animals; Antioxidants; Aorta, Thoracic; Arginine; Biopterins; Cells, Cultured; Cystathionine beta-Synthase; Endothelium, Vascular; Enzyme Activation; Female; Gene Expression Regulation, Enzymologic; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Homocysteine; Humans; Hyperhomocysteinemia; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Protein Kinase C; Pterins; Superoxide Dismutase; Vasodilation

2005
Tetrahydrobiopterin, but not L-arginine, decreases NO synthase uncoupling in cells expressing high levels of endothelial NO synthase.
    Hypertension (Dallas, Tex. : 1979), 2006, Volume: 47, Issue:1

    Topics: Antioxidants; Arginine; Biopterins; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Humans; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Reactive Oxygen Species; Vascular Endothelial Growth Factor A

2006
Reactivity of the heme-dioxygen complex of the inducible nitric oxide synthase in the presence of alternative substrates.
    The FEBS journal, 2006, Volume: 273, Issue:1

    Topics: Animals; Arginine; Biopterins; Guanidines; Heme; Kinetics; Mice; Models, Chemical; Nitric Oxide Synthase Type II; Oxygen; Substrate Specificity

2006
Regulation of the monomer-dimer equilibrium in inducible nitric-oxide synthase by nitric oxide.
    The Journal of biological chemistry, 2006, Mar-24, Volume: 281, Issue:12

    Topics: Amino Acid Motifs; Animals; Arginine; Biopterins; Chelating Agents; Chromatography; Cysteine; Dimerization; Disulfides; Escherichia coli; Heme; Iron; Mass Spectrometry; Mice; Models, Chemical; Models, Molecular; Molecular Conformation; Nitric Oxide; Nitric Oxide Synthase Type II; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Spectrophotometry; Spectrum Analysis, Raman; Structure-Activity Relationship; Sulfhydryl Compounds; Time Factors; Urea; Zinc

2006
Regulation of inducible nitric oxide synthase in post-operative adhesions.
    Human reproduction (Oxford, England), 2006, Volume: 21, Issue:6

    Topics: Animals; Arginine; Biopsy; Biopterins; Citrulline; Female; Fibroblasts; Gene Expression Regulation, Enzymologic; Humans; Nitric Oxide Synthase Type II; Oxygen; Rats; Rats, Sprague-Dawley; Tissue Adhesions

2006
Reduction of myocardial infarct size by tetrahydrobiopterin: possible involvement of mitochondrial KATP channels activation through nitric oxide production.
    Journal of cardiovascular pharmacology, 2006, Volume: 47, Issue:2

    Topics: Animals; Anti-Arrhythmia Agents; Arginine; Biopterins; Cyclic GMP; Decanoic Acids; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hydroxy Acids; Male; Malondialdehyde; Myocardial Infarction; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitrites; Potassium Channels; Rats; Rats, Sprague-Dawley

2006
Inefficient spin trapping of superoxide in the presence of nitric-oxide: implications for studies on nitric-oxide synthase uncoupling.
    Free radical biology & medicine, 2006, Aug-01, Volume: 41, Issue:3

    Topics: Animals; Arginine; Biopterins; Cell Line; Electrochemistry; Electron Spin Resonance Spectroscopy; Nitric Oxide; Nitric Oxide Synthase Type III; Protein Binding; Pyrroles; Rats; Spin Trapping; Spodoptera; Superoxide Dismutase; Superoxides

2006
The role of tetrahydrobiopterin in catalysis by nitric oxide synthase.
    Chemical communications (Cambridge, England), 2006, Sep-07, Issue:33

    Topics: Algorithms; Arginine; Binding Sites; Biopterins; Catalysis; Electron Transport; Heme; Molecular Structure; Nitric Oxide Synthase; Protons

2006
Nitric oxide and neopterin in bipolar affective disorder.
    Neuropsychobiology, 2006, Volume: 54, Issue:1

    Topics: Adult; Arginine; Biopterins; Bipolar Disorder; Chi-Square Distribution; Citrulline; Female; Humans; Male; Mental Status Schedule; Middle Aged; Neopterin; Nitric Oxide

2006
Oral administration of both tetrahydrobiopterin and L-arginine prevents endothelial dysfunction in rats with chronic renal failure.
    Journal of cardiovascular pharmacology, 2007, Volume: 49, Issue:3

    Topics: Acetylcholine; Administration, Oral; Animals; Aorta; Arginine; Biopterins; Blood Pressure; Calcimycin; Drug Synergism; Drug Therapy, Combination; Endothelium, Vascular; Kidney Failure, Chronic; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Superoxides

2007
Oxygen metabolism by endothelial nitric-oxide synthase.
    The Journal of biological chemistry, 2007, Sep-28, Volume: 282, Issue:39

    Topics: Animals; Arginine; Biopterins; Catalysis; Humans; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Nitrosamines; Oxygen; Reactive Oxygen Species; Recombinant Proteins

2007
Changes of asymmetric dimethylarginine, nitric oxide, tetrahydrobiopterin, and oxidative stress in patients with acute myocardial infarction by medical treatments.
    Clinical hemorheology and microcirculation, 2007, Volume: 37, Issue:3

    Topics: Adult; Aged; Arginine; Biopterins; Case-Control Studies; Drug Therapy; Endothelium, Vascular; Female; Humans; Lipoproteins, LDL; Male; Middle Aged; Myocardial Infarction; Nitric Oxide; Oxidative Stress; Superoxides

2007
Oxygenase domain of Drosophila melanogaster nitric oxide synthase: unique kinetic parameters enable a more efficient NO release.
    Biochemistry, 2007, Oct-23, Volume: 46, Issue:42

    Topics: Animals; Arginine; Biopterins; Buffers; Catalysis; Computer Simulation; Drosophila melanogaster; Edetic Acid; Escherichia coli; Ferrous Compounds; Heme; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Oxygenases; Protein Structure, Tertiary; Spectrophotometry, Ultraviolet; Temperature

2007
Oxygen-induced radical intermediates in the nNOS oxygenase domain regulated by L-arginine, tetrahydrobiopterin, and thiol.
    Biochemistry, 2008, Jan-08, Volume: 47, Issue:1

    Topics: Animals; Arginine; Biopterins; Electron Spin Resonance Spectroscopy; Kinetics; Nitric Oxide Synthase Type I; Oxidation-Reduction; Oxygen; Protein Binding; Protein Structure, Tertiary; Rats; Reactive Oxygen Species

2008
Ageing diminishes endothelium-dependent vasodilatation and tetrahydrobiopterin content in rat skeletal muscle arterioles.
    The Journal of physiology, 2008, Feb-15, Volume: 586, Issue:4

    Topics: Aging; Animals; Arginase; Arginine; Arterioles; Biopterins; Endothelium, Vascular; Enzyme Inhibitors; Male; Muscle, Skeletal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Pterins; Rats; Rats, Inbred F344; Vasodilation

2008
Catalytic reduction of a tetrahydrobiopterin radical within nitric-oxide synthase.
    The Journal of biological chemistry, 2008, Apr-25, Volume: 283, Issue:17

    Topics: Animals; Arginine; Biopterins; Catalysis; Crystallography, X-Ray; Electron Spin Resonance Spectroscopy; Flavins; Free Radicals; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Pterins; Rats

2008
Regulation of eNOS-derived superoxide by endogenous methylarginines.
    Biochemistry, 2008, Jul-08, Volume: 47, Issue:27

    Topics: Arginine; Biopterins; Electron Spin Resonance Spectroscopy; Heme; Humans; NADP; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Superoxides

2008
Dietary supplementation with cholesterol and docosahexaenoic acid increases the activity of the arginine-nitric oxide pathway in tissues of young pigs.
    Nitric oxide : biology and chemistry, 2008, Volume: 19, Issue:3

    Topics: Analysis of Variance; Animals; Animals, Newborn; Arginine; Biopterins; Blotting, Western; Brain; Cholesterol, Dietary; Chromatography, High Pressure Liquid; Citrulline; Dietary Supplements; Docosahexaenoic Acids; GTP Cyclohydrolase; Liver; Muscle, Skeletal; NADP; Nitric Oxide; Nitric Oxide Synthase; Swine

2008
Generalised cranial artery spasm in human rabies.
    Developments in biologicals, 2008, Volume: 131

    Topics: Animals; Arginine; Biopterins; Blood Flow Velocity; Cerebral Arteries; Cerebrovascular Circulation; Child; Chiroptera; Dog Diseases; Dogs; Humans; Nitric Oxide Synthase; Nitroprusside; Rabies; Treatment Outcome; Ultrasonography, Doppler, Transcranial; Vasospasm, Intracranial; Zoonoses

2008
Stabilization and characterization of a heme-oxy reaction intermediate in inducible nitric-oxide synthase.
    The Journal of biological chemistry, 2008, Nov-28, Volume: 283, Issue:48

    Topics: Amino Acid Substitution; Animals; Arginine; Biopterins; Catalytic Domain; Crystallography, X-Ray; Electrochemistry; Free Radicals; Heme; Kinetics; Mice; Mutation, Missense; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidation-Reduction

2008
Physarum nitric oxide synthases: genomic structures and enzymology of recombinant proteins.
    The Biochemical journal, 2009, Mar-15, Volume: 418, Issue:3

    Topics: Animals; Arginine; Base Sequence; Biopterins; Flavin Mononucleotide; Isoenzymes; Molecular Sequence Data; Nitric Oxide Synthase; Physarum polycephalum; RNA, Messenger

2009
Effect of uncoupling endothelial nitric oxide synthase on calcium homeostasis in aged porcine endothelial cells.
    Cardiovascular research, 2009, Apr-01, Volume: 82, Issue:1

    Topics: Animals; Arginine; Biopterins; Bradykinin; Calcium; Cells, Cultured; Cellular Senescence; Citrulline; Cyclic GMP; Endothelial Cells; Enzyme Inhibitors; Homeostasis; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Superoxides; Swine; Time Factors

2009
Detrimental effect of combined exercise training and eNOS overexpression on cardiac function after myocardial infarction.
    American journal of physiology. Heart and circulatory physiology, 2009, Volume: 296, Issue:5

    Topics: Acetylcysteine; Actin Cytoskeleton; Animals; Antioxidants; Arginine; Biopterins; Disease Models, Animal; Exercise Therapy; Female; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myocardial Contraction; Myocardial Infarction; Myocardium; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphorylation; Physical Exertion; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Superoxides; Time Factors; Up-Regulation; Ventricular Dysfunction, Left; Ventricular Pressure; Ventricular Remodeling

2009
Arginase contributes to endothelial cell oxidative stress in response to plasma from women with preeclampsia.
    Cardiovascular research, 2010, Jan-01, Volume: 85, Issue:1

    Topics: Arginase; Arginine; Biopterins; Endothelial Cells; Female; Humans; Molsidomine; NADPH Oxidases; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxidative Stress; Peroxynitrous Acid; Pre-Eclampsia; Pregnancy

2010
Alterations in the modulation of cerebrovascular tone and blood flow by nitric oxide synthases in SHRsp with stroke.
    Cardiovascular research, 2010, Apr-01, Volume: 86, Issue:1

    Topics: Animals; Arginine; Biopterins; Blood Pressure; Cerebral Hemorrhage; Cerebrovascular Circulation; Enzyme Inhibitors; Homeostasis; Hypertension; Male; Middle Cerebral Artery; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Inbred SHR; Stroke; Vasodilation

2010
L-arginine and antioxidant diet supplementation partially restores nitric oxide-dependent regulation of phenylephrine renal vasoconstriction in diabetics rats.
    Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 2010, Volume: 20, Issue:3

    Topics: Animals; Antioxidants; Arginine; Ascorbic Acid; Biopterins; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dietary Supplements; Docosahexaenoic Acids; Eicosapentaenoic Acid; Enzyme Inhibitors; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phenylephrine; Rats; Rats, Wistar; Reactive Oxygen Species; Superoxides; Vasoconstriction; Vasoconstrictor Agents; Vitamin E

2010
Decreased arteriolar tetrahydrobiopterin is linked to superoxide generation from nitric oxide synthase in mice fed high salt.
    Microcirculation (New York, N.Y. : 1994), 2010, Volume: 17, Issue:2

    Topics: Animals; Arginine; Arterioles; Biopterins; GTP Cyclohydrolase; Male; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type III; Sodium Chloride, Dietary; Superoxides; Vasodilation

2010
Tetrahydrobiopterin depletion and NOS2 uncoupling contribute to heart failure-induced alterations in atrial electrophysiology.
    Cardiovascular research, 2011, Jul-01, Volume: 91, Issue:1

    Topics: Action Potentials; Animals; Arginine; Atrial Fibrillation; Atrial Function, Left; Biopterins; Cardiac Pacing, Artificial; Disease Models, Animal; Dogs; Female; Heart Atria; Heart Failure; Kinetics; Male; Myocardium; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Patch-Clamp Techniques; Superoxides; Up-Regulation; Ventricular Function, Left

2011
Spectroscopic, catalytic and binding properties of Bacillus subtilis NO synthase-like protein: comparison with other bacterial and mammalian NO synthases.
    Journal of inorganic biochemistry, 2012, Volume: 106, Issue:1

    Topics: Animals; Arginine; Bacillus subtilis; Bacteria; Bacterial Proteins; Binding Sites; Biocatalysis; Biopterins; Citrulline; Ferric Compounds; Ferrous Compounds; Heme; Hydrogen Peroxide; Imidazoles; Kinetics; Mammals; Nitric Oxide Synthase; Oxidation-Reduction; Protein Binding; Recombinant Proteins; Species Specificity; Spectrophotometry

2012
Changes in eNOS phosphorylation contribute to increased arteriolar NO release during juvenile growth.
    American journal of physiology. Heart and circulatory physiology, 2012, Feb-01, Volume: 302, Issue:3

    Topics: Acetylcholine; Animals; Arginine; Arterioles; Biopterins; Calcimycin; Calcium Ionophores; Endothelium, Vascular; HSP90 Heat-Shock Proteins; Male; Muscle, Skeletal; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Rats; Rats, Sprague-Dawley; Vasodilator Agents

2012
Arg375 tunes tetrahydrobiopterin functions and modulates catalysis by inducible nitric oxide synthase.
    Journal of inorganic biochemistry, 2012, Volume: 108

    Topics: Arginine; Biopterins; Catalysis; Hydrogen Bonding; Mutagenesis, Site-Directed; Nitric Oxide Synthase Type II; Protein Binding; Protein Multimerization; Protein Structure, Secondary

2012
New role for L-arginine in regulation of inducible nitric-oxide-synthase-derived superoxide anion production in raw 264.7 macrophages.
    TheScientificWorldJournal, 2011, Volume: 11

    Topics: Animals; Arginine; Biopterins; Cell Line; Cell Survival; Enzyme Activation; Enzyme Inhibitors; Escherichia coli; Lipopolysaccharides; Macrophages; Mice; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Respiratory Burst; Superoxides; Time Factors; Tyrosine

2011
Tetrahydrobiopterin, L-arginine and vitamin C actsynergistically to decrease oxidative stress, increase nitricoxide and improve blood flow after induction of hindlimbischemia in the rat.
    Molecular medicine (Cambridge, Mass.), 2012, May-09, Volume: 18

    Topics: Administration, Oral; Animals; Antioxidants; Arginine; Ascorbic Acid; Biopterins; Calcium; Drug Synergism; Enzyme Activation; Hindlimb; Ischemia; Male; Muscle, Skeletal; Necrosis; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Sprague-Dawley; Regional Blood Flow

2012
A novel cryo-reduction method to investigate the molecular mechanism of nitric oxide synthases.
    The journal of physical chemistry. B, 2012, May-17, Volume: 116, Issue:19

    Topics: Animals; Arginine; Bacterial Proteins; Biochemistry; Biopterins; Catalytic Domain; Cold Temperature; Dose-Response Relationship, Radiation; Electrons; Gamma Rays; Isoenzymes; Mice; Models, Molecular; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Oxygen; Recombinant Proteins; Spectrum Analysis, Raman

2012
Role of neural NO synthase (nNOS) uncoupling in the dysfunctional nitrergic vasorelaxation of penile arteries from insulin-resistant obese Zucker rats.
    PloS one, 2012, Volume: 7, Issue:4

    Topics: Acetophenones; Animals; Arginine; Arteries; Biopterins; Calcium; Electric Stimulation; Endothelium, Vascular; Erectile Dysfunction; GTP Cyclohydrolase; Insulin Resistance; Male; Metabolic Syndrome; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; Obesity; Oxidative Stress; Penis; Rats; Rats, Zucker; Signal Transduction; Superoxides; Vasodilation

2012
Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I.
    Free radical biology & medicine, 2012, Jul-15, Volume: 53, Issue:2

    Topics: Acetylcarnitine; Adaptor Proteins, Signal Transducing; Animals; Animals, Newborn; Arginine; Biopterins; Disease Models, Animal; Endothelial Cells; Female; GTP Cyclohydrolase; HSP70 Heat-Shock Proteins; Hypertension, Pulmonary; Mitochondria; Nitric Oxide; Nitric Oxide Synthase; Pregnancy; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pulmonary Artery; Pulmonary Heart Disease; Sheep; Signal Transduction; Ubiquitin-Protein Ligases; Ubiquitination

2012
Beneficial effects of the active principle component of Korean cabbage kimchi via increasing nitric oxide production and suppressing inflammation in the aorta of apoE knockout mice.
    The British journal of nutrition, 2013, Jan-14, Volume: 109, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Aortitis; Apolipoproteins E; Arginine; Atherosclerosis; Biopterins; Cell Adhesion Molecules; Diet, Atherogenic; Disease Models, Animal; Down-Regulation; Injections, Intraperitoneal; Male; Mice; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase Type III; Phenyl Ethers; Propionates; Random Allocation; Reactive Oxygen Species; Up-Regulation

2013
Electron paramagnetic resonance characterization of tetrahydrobiopterin radical formation in bacterial nitric oxide synthase compared to mammalian nitric oxide synthase.
    Biophysical journal, 2012, Jul-03, Volume: 103, Issue:1

    Topics: Animals; Arginine; Bacillus subtilis; Bacterial Proteins; Biopterins; Electron Spin Resonance Spectroscopy; Escherichia coli; Free Radicals; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Rats; Species Specificity

2012
Mechanism of cellular oxidation stress induced by asymmetric dimethylarginine.
    International journal of molecular sciences, 2012, Volume: 13, Issue:6

    Topics: Arginine; Biopterins; Enzyme Inhibitors; Human Umbilical Vein Endothelial Cells; Humans; Lysine; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress

2012
Tetrahydrobiopterin, L-arginine and vitamin C act synergistically to decrease oxidant stress and increase nitric oxide that increases blood flow recovery after hindlimb ischemia in the rat.
    Molecular medicine (Cambridge, Mass.), 2012, Oct-24, Volume: 18

    Topics: Administration, Oral; Animals; Arginine; Ascorbic Acid; Biopterins; Calcium; Drug Synergism; Hindlimb; Ischemia; Male; Models, Biological; Muscles; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Phosphorylation; Rats; Rats, Sprague-Dawley; Recovery of Function; Regional Blood Flow

2012
Ascorbate in aqueous humor augments nitric oxide production by macrophages.
    Journal of immunology (Baltimore, Md. : 1950), 2013, Jan-15, Volume: 190, Issue:2

    Topics: alpha-MSH; Amino Acid Transport Systems, Basic; Animals; Aqueous Humor; Arginase; Arginine; Ascorbic Acid; Biological Transport; Biopterins; Calcitonin Gene-Related Peptide; Eye Proteins; Female; Gene Expression Regulation; GTP Cyclohydrolase; Macrophages; Male; Mice; Mice, Knockout; Nerve Growth Factors; Nitric Oxide; Nitric Oxide Synthase Type II; Protein Multimerization; Rabbits; Serpins; Transforming Growth Factor beta2

2013
Mechanism of inducible nitric-oxide synthase dimerization inhibition by novel pyrimidine imidazoles.
    The Journal of biological chemistry, 2013, Jul-05, Volume: 288, Issue:27

    Topics: Amino Acid Substitution; Animals; Arginine; Biopterins; Cell Line; Enzyme Inhibitors; Heme; Imidazoles; Mice; Mutation, Missense; Nitric Oxide Synthase Type II; Protein Multimerization; Pyrimidines

2013
The intracellular environment of human macrophages that produce nitric oxide promotes growth of mycobacteria.
    Infection and immunity, 2013, Volume: 81, Issue:9

    Topics: Arginine; Biopterins; Cell Line; Humans; Interferon-gamma; Macrophages; Mycobacterium bovis; Mycobacterium tuberculosis; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Reactive Nitrogen Species

2013
Exhaled nitric oxide measurement to monitor pulmonary hypertension in a pneumonectomy-monocrotaline rat model.
    American journal of physiology. Lung cellular and molecular physiology, 2013, Oct-01, Volume: 305, Issue:7

    Topics: Animals; Arginine; Arterial Pressure; Biomarkers; Biopterins; Exhalation; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Nitric Oxide; Pneumonectomy; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley

2013
Modulation of NO and ROS production by AdiNOS transduced vascular cells through supplementation with L-Arg and BH4: implications for gene therapy of restenosis.
    Atherosclerosis, 2013, Volume: 230, Issue:1

    Topics: Adenoviridae; Animals; Aorta; Arginine; Biopterins; Carotid Arteries; Cell Proliferation; Cell Survival; Coronary Restenosis; Cross-Linking Reagents; Disease Models, Animal; Genetic Therapy; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species

2013
Myocardial protection by co-administration of L-arginine and tetrahydrobiopterin during ischemia and reperfusion.
    International journal of cardiology, 2013, Oct-25, Volume: 169, Issue:1

    Topics: Animals; Arginine; Biopterins; Cardiotonic Agents; Drug Therapy, Combination; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley; Sus scrofa; Swine

2013
L-arginine and tetrahydrobiopterin, but not sodium nitrite partially restored erectile dysfunction in aged rats.
    The aging male : the official journal of the International Society for the Study of the Aging Male, 2014, Volume: 17, Issue:4

    Topics: Aging; Animals; Arginine; Biopterins; Dose-Response Relationship, Drug; Erectile Dysfunction; Male; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Penile Erection; Penis; Rats, Wistar; Sodium Nitrite

2014
Insulin reverses D-glucose-increased nitric oxide and reactive oxygen species generation in human umbilical vein endothelial cells.
    PloS one, 2015, Volume: 10, Issue:4

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetophenones; Arginine; Biopterins; Calcitonin Gene-Related Peptide; Cationic Amino Acid Transporter 1; Cyclic N-Oxides; Gene Expression Regulation; Glucose; Human Umbilical Vein Endothelial Cells; Humans; Insulin; Mitogen-Activated Protein Kinase 1; Nitric Oxide; Nitric Oxide Synthase Type III; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; Spin Labels; Tissue Culture Techniques; Transcription Factors; Umbilical Veins; Vasoconstrictor Agents

2015
Serine 1179 Phosphorylation of Endothelial Nitric Oxide Synthase Increases Superoxide Generation and Alters Cofactor Regulation.
    PloS one, 2015, Volume: 10, Issue:11

    Topics: Animals; Arginine; Biopterins; Calcium; Calmodulin; Cattle; Cell Survival; Citrulline; Electron Spin Resonance Spectroscopy; Endothelium, Vascular; HEK293 Cells; Humans; Mutation; NADP; Nitric Oxide Synthase Type III; Oxygen; Phosphorylation; Reactive Oxygen Species; Recombinant Proteins; Serine; Spin Trapping; Superoxides; Vascular Endothelial Growth Factor A

2015
Tetrahydrobiopterin Supplementation Improves Phenylalanine Metabolism in a Murine Model of Severe Malaria.
    ACS infectious diseases, 2016, 11-11, Volume: 2, Issue:11

    Topics: Animals; Aorta; Arginine; Biopterins; Brain; Disease Models, Animal; Humans; Malaria; Mice; Mice, Inbred C57BL; Nitric Oxide; Phenylalanine; Plasmodium berghei

2016
Tetrahydrobiopterin redox cycling in nitric oxide synthase: evidence supports a through-heme electron delivery.
    The FEBS journal, 2016, Volume: 283, Issue:24

    Topics: Animals; Arginine; Biocatalysis; Biopterins; Electron Spin Resonance Spectroscopy; Electron Transport; Electrons; Free Radicals; Heme; Kinetics; Models, Molecular; Molecular Structure; Mutation; Nitric Oxide Synthase Type I; Oxidation-Reduction; Protein Binding; Protein Domains; Rats

2016
Theoretical studies of the second step of the nitric oxide synthase reaction: Electron tunneling prevents uncoupling.
    Journal of inorganic biochemistry, 2018, Volume: 181

    Topics: Animals; Arginine; Biocatalysis; Biopterins; Catalytic Domain; Citrulline; Conserved Sequence; Databases, Protein; Electron Transport; Humans; Hydrogen Bonding; Models, Molecular; NADP; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidation-Reduction; Protons; Quantum Theory; Thermodynamics

2018
Tetrahydrobiopterin improves hippocampal nitric oxide-linked long-term memory.
    Molecular genetics and metabolism, 2018, Volume: 125, Issue:1-2

    Topics: Animals; Arginine; Biopterins; Female; GTP Cyclohydrolase; Hippocampus; Humans; Male; Memory, Long-Term; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase; Rats, Wistar; Signal Transduction

2018
L-Arginine and tetrahydrobiopterin supported nitric oxide production is crucial for the microbicidal activity of neutrophils.
    Free radical research, 2019, Volume: 53, Issue:3

    Topics: Adult; Arginine; Biopterins; Female; Humans; Male; Middle Aged; Neutrophils; Nitric Oxide

2019
Combined l-citrulline and tetrahydrobiopterin therapy improves NO signaling and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs.
    American journal of physiology. Lung cellular and molecular physiology, 2020, 04-01, Volume: 318, Issue:4

    Topics: Animals; Animals, Newborn; Arginine; Biopterins; Citrulline; Hypertension, Pulmonary; Hypoxia; Nitric Oxide; Nitric Oxide Synthase Type III; Pulmonary Artery; Signal Transduction; Swine; Vascular Resistance

2020
Correction of arginine metabolism with sepiapterin-the precursor of nitric oxide synthase cofactor BH
    Biochemical pharmacology, 2020, Volume: 176

    Topics: Arginine; B7-H1 Antigen; Biopterins; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Humans; Macrophages; Nitric Oxide; Nitric Oxide Synthase; Polyamines; Pterins; STAT3 Transcription Factor; THP-1 Cells

2020
Decreased Expression and Uncoupling of Endothelial Nitric Oxide Synthase in the Cerebral Cortex of Rats with Thioacetamide-Induced Acute Liver Failure.
    International journal of molecular sciences, 2021, Jun-22, Volume: 22, Issue:13

    Topics: Animals; Arginine; Biopterins; Cerebral Cortex; Cerebrovascular Circulation; Gene Expression Regulation; Hepatic Encephalopathy; Liver Failure, Acute; Male; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Thioacetamide

2021
Cumulative effect of simvastatin, L-arginine, and tetrahydrobiopterin on cerebral blood flow and cognitive function in Alzheimer's disease.
    Alzheimer's research & therapy, 2022, 09-17, Volume: 14, Issue:1

    Topics: Alzheimer Disease; Arginine; Biopterins; Cerebrovascular Circulation; Cognition; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Neuropsychological Tests; Nitric Oxide Synthase Type III; Proof of Concept Study; Simvastatin

2022
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