arginine and sapropterin
arginine has been researched along with sapropterin in 230 studies
Research
Studies (230)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (0.43) | 18.7374 |
1990's | 83 (36.09) | 18.2507 |
2000's | 101 (43.91) | 29.6817 |
2010's | 41 (17.83) | 24.3611 |
2020's | 4 (1.74) | 2.80 |
Authors
Authors | Studies |
---|---|
Gross, SS; Levi, R | 1 |
Bult, H; Herman, AG; Jorens, PG; van Overveld, FJ; Vermeire, PA | 1 |
Böhme, E; Heinzel, B; John, M; Klatt, P; Mayer, B; Schmidt, K | 1 |
Van Amsterdam, JG; Wemer, J | 1 |
Ishihara, T; Kanai, T; Noguchi, T; Nunokawa, Y | 1 |
Böhme, E; Heinzel, B; John, M; Klatt, P; Mayer, B | 1 |
Datto, GA; Wolff, DJ | 1 |
Fleming, I; Gray, GA; Schott, C; Stoclet, JC | 1 |
Busse, R; Mülsch, A | 1 |
Campos, KL; Giovanelli, J; Kaufman, S | 1 |
Gross, SS; Jaffe, EA; Kilbourn, RG; Levi, R | 1 |
Böhme, E; Heinzel, B; John, M; Mayer, B; Schultz, G; Wachter, H; Werner, ER | 1 |
Förstermann, U; Mitchell, JA; Murad, F; Sheng, H | 1 |
Marletta, MA; Tayeh, MA | 1 |
Billiar, TR; Di Silvio, M; Freeswick, P; Geller, DA; Gross, SS; Nussler, A; Simmons, RL | 1 |
Fukuto, JM; Griscavage, JM; Ignarro, LJ; Komori, Y | 1 |
Klatt, P; Mayer, B; Schmidt, K; Werner, ER | 1 |
Billiar, TR; Di Silvio, M; Freeswick, PD; Geller, DA; Lancaster, JR; Liu, ZZ; Lowenstein, CL; Nussler, AK; Simmons, RL; Sweetland, MA | 1 |
Chen, Y; Rosazza, JP | 1 |
Doppler, W; Fuchs, D; Goossen, B; Grünewald, K; Hentze, MW; Pantopoulos, K; Wachter, H; Weiss, G; Werner-Felmayer, G | 1 |
McCreedy, SA; Reif, DW | 1 |
Brand, MP; Clark, JB; Heales, SJ; Land, JM | 1 |
Bächinger, HP; Glatter, O; Klatt, P; Lehner, D; Mayer, B; Schmidt, K | 1 |
Hofmann, H; Schmidt, HH | 1 |
Blau, N; Guerrero, L; Hofer, S; Schaffner, A; Schneemann, M; Schoedon, G | 1 |
Klatt, P; Mayer, B; Schmidt, K; Uray, G | 1 |
Kim, YM; Lancaster, JR | 1 |
Lancaster, JR; Wachter, H; Werner-Felmayer, G | 1 |
Heyes, MP; Kaufman, S; Milstien, S; Saito, K; Sakai, N | 1 |
Citron, BA; Davis, MD; Greene, CL; Kaufman, S; Milstien, S; Naylor, EW | 1 |
Lincoln, J; Messersmith, WA | 1 |
Albakri, QA; Stuehr, DJ | 1 |
Gerber, NC; Ortiz de Montellano, PR; Rodríguez-Crespo, I | 1 |
Giovanelli, J; Kaufman, S; Witteveen, CF | 2 |
Bächinger, HP; Glatter, O; Klatt, P; Lehner, D; List, BM; Mayer, B; Pfeiffer, S; Schmidt, K; Werner, ER | 1 |
Boyhan, A; Charles, I; Lowe, PN; Moncada, S; Riveros-Moreno, V; Smith, D; Stammers, DK | 1 |
Cañada, FJ; Lamas, S; Pérez-Sala, D; Saura, M | 1 |
Klatt, P; List, BM; Mayer, B; Schmidt, K; Werner, ER | 1 |
Hertelendy, F; Kukor, Z; Mészáros, G; Tóth, M | 1 |
Calaycay, JR; Chabin, RM; Hutchinson, NI; Kelly, TM; Kozarich, JW; MacNaul, KL; Madhusudanaraju, S; McCauley, E; Schmidt, JA; Wolfe, GC; Wong, KK | 1 |
Kelly, RA; Simmons, WW; Smith, GK; Smith, TW; Ungureanu-Longrois, D | 1 |
Eberhardt, W; Hummel, R; Kunz, D; Mühl, H; Nitsch, D; Pfeilschifter, J; Plüss, C; Walker, G | 1 |
Blau, N; Linscheid, P; Schaffner, A; Schneemann, M; Schoedon, G; Walter, R | 1 |
Ju, H; Ryan, JW; Venema, RC; Venema, VJ; Zou, R | 1 |
Cosentino, F; Erkelens, W; Kastelein, J; Koomans, H; Lüscher, T; Rabelink, T; Stroes, E; Wever, R | 1 |
Gerber, NC; Nishida, CR; Ortiz de Montellano, PR; Rodriguez-Crespo, I | 1 |
Gorren, AC; Mayer, B; Schmidt, K; Schrammel, A | 2 |
Crane, BR; Gachhui, R; Ghosh, DK; Parkinson, J; Stuehr, DJ; Wu, C | 1 |
Boyhan, A; Charles, IG; Lowe, PN; Saqi, M; Smith, D | 1 |
Abu-Soud, HM; Gachhui, R; Raushel, FM; Stuehr, DJ | 1 |
Beasjours, S; Guo, Y; Hussain, SN; Mori, M; Ward, ME | 1 |
Loehr, TM; Moënne-Loccoz, P; Ortiz de Montellano, PR; Rodríguez-Crespo, I | 1 |
Brand, MP; Heales, SJ; Lindley, KJ; Milla, PJ; Rolfe, VE | 1 |
Arvai, AS; Crane, BR; Gachhui, R; Getzoff, ED; Ghosh, DK; Stuehr, DJ; Tainer, JA; Wu, C | 1 |
Harrison, DG | 1 |
Nishida, CR; Ortiz de Montellano, PR | 1 |
Arvai, AS; Crane, BR; Getzoff, ED; Ghosh, DK; Stuehr, DJ; Tainer, JA; Wu, C | 1 |
Alderton, WK; Boyhan, A; Lowe, PN | 1 |
Ishii, M; Momose, K; Shimizu, S; Yamamoto, T | 1 |
Kaufman, S; Liang, LP | 1 |
Daff, S; Ito, O; Nomura, S; Sagami, I; Sato, H; Shimizu, T | 1 |
Hogg, N; Kalyanaraman, B; Karoui, H; Martásek, P; Masters, BS; Pritchard, KA; Tordo, P; Vásquez-Vivar, J | 1 |
Daff, S; Nakano, K; Sagami, I; Shimizu, T | 1 |
Berka, V; Tsai, AL; Xia, Y; Zweier, JL | 1 |
Marletta, MA; Rusche, KM; Spiering, MM | 1 |
Hurshman, AR; Marletta, MA; Rusche, KM | 1 |
Gross, SS; Ikeda-Saito, M; Liu, Q; Martásek, P; Masters, BS; Migita, CT; Miller, RT; Raman, CS; Roman, LJ; Salerno, JC | 1 |
Andrew, PJ; Brunner, K; Hemmens, B; Kungl, AJ; Mayer, B; Tortschanoff, A | 1 |
Daff, S; Sagami, I; Sato, H; Shimizu, T | 1 |
Dolphin, E; Fischmann, TO; Fossetta, JD; Hruza, A; Lundell, DJ; Lunn, CA; Narula, SK; Niu, XD; Prongay, AJ; Reichert, P; Weber, PC | 1 |
Boyington, JC; Kulansky, R; Malech, HL; Rafferty, SP; Sun, PD | 1 |
Ludwig, ML; Marletta, MA | 1 |
McMurtry, IF; Rodman, DM; Sato, K | 1 |
Bhagat, K; Charles, IG; Hingorani, AD; Palacios, M; Vallance, P | 1 |
Berka, V; Lambry, JC; Liebl, U; Martin, JL; Négrerie, M; Tsai, AL; Vos, MH | 1 |
Bömmel, HM; Frey, A; Fröhlich, LG; Kotsonis, P; Pfleiderer, W; Reif, A; Schmidt, HH; Wink, DA | 1 |
Hogg, N; Kalyanaraman, B; Karoui, H; Martásek, P; Pritchard, KA; Vásquez-Vivar, J | 1 |
Boucher, JL; Moali, C; Tenu, JP | 1 |
Cosentino, F; Lüscher, TF | 1 |
Ishii, M; Kawakami, Y; Kiuchi, Y; Momose, K; Shimizu, S; Yamamoto, T | 1 |
Edmondson, DE; Hurshman, AR; Huynh, BH; Krebs, C; Marletta, MA | 1 |
Andrew, PJ; Mayer, B | 1 |
Fröhlich, LG; Horejsi, R; Kotsonis, P; Pfleiderer, W; Schmidt, HH; Shutenko, ZV | 1 |
Huang, A; Keaney, JF; Venema, RC; Vita, JA | 1 |
Arvai, AS; Crane, BR; Getzoff, ED; Ghosh, S; Stuehr, DJ; Tainer, JA | 1 |
Daff, S; Sagami, I; Sato, Y; Shimizu, T | 1 |
Hatakeyama, K; Kelly, KA; Marinos, RS; Martinez-Zaguilan, R; Meininger, CJ; Rojas, JD; Wu, G | 1 |
Berka, V; Tsai, AL | 1 |
Kankaanranta, H; Lähde, M; Lahti, A; Moilanen, E | 1 |
Adak, S; Stuehr, DJ; Wang, Q | 1 |
Ghosh, DK; Jung, C; Stuehr, DJ | 1 |
Bec, N; Gorren, AC; Lange, R; Mayer, B; Schrammel, A; Werner, ER | 1 |
Hemann, C; Hille, R; Meade, AL; Stuehr, DJ; Wang, Q; Wang, ZQ; Wei, CC | 1 |
Hurt, RD; Miller, VM; Severson, SR; Tonnessen, BH | 1 |
Bruner, E; Magde, D; Martásek, P; Masters, BS; Roman, LJ; Scheele, JS; Sharma, VS; Zemojtel, T | 1 |
Jiang, J; Pernow, J; Thorén, P; Tokuno, S; Valen, G | 1 |
Cioffi, FA; d'Ischia, M; Palumbo, A | 1 |
Assreuy, J; Guimarães, C; Linden, R | 1 |
Furukawa, A; Ichikawa, M; Ichikawa, Y; Jiang, H; Ohnishi, T; Tomita, S | 1 |
Boucher, JL; Mansuy, D; Moali, C; Renodon-Corniere, A; Stuehr, DJ | 1 |
Gräbner, R; Heller, R; Malle, E; Marsche, G; Nuszkowski, A; Unbehaun, A | 1 |
Daff, S; Noguchi, T; Sagami, I; Shimizu, T | 1 |
Blum, M; Chernichowski, T; Iaina, A; Levo, Y; Schwartz, D; Schwartz, IF; Wollman, Y | 1 |
Astarita, G; d'Ischia, M; Palumbo, A | 1 |
Tiefenbacher, CP | 1 |
Prabhakar, SS | 1 |
Hori, M; Karaki, H; Murata, T; Ozaki, H; Sato, K; Yamawaki, H | 1 |
Cosper, NJ; Hori, H; Iwasaki, T; Nishino, T; Scott, RA | 1 |
Ghosh, S; Hemann, C; Hille, R; Meade, AL; Stuehr, DJ; Wang, ZQ; Wei, CC | 1 |
Ishii, M; Iwasaki, M; Kiuchi, Y; Shimizu, S; Shiota, K; Yamamoto, T | 1 |
Berka, V; Lambry, JC; Martin, JL; Négrerie, M; Slama-Schwok, A; Tsai, AL; Vos, MH | 1 |
George, SC; Kwon, S; Newcomb, RL | 1 |
d'Ischia, M; Napolitano, A; Palumbo, A | 1 |
Dunster, C; Grieve, DJ; Kelly, FJ; Li, JM; MacCarthy, PA; Shah, AM | 1 |
Conrad, KP; Davis, AK; Novak, J; Powers, RW | 1 |
Adak, S; Aulak, KS; Bilwes, AM; Crane, BR; Getzoff, ED; Hosfield, D; McDonald, JF; Panda, K; Stuehr, DJ; Tainer, JA | 1 |
Lüscher, TF; Noll, G; Spieker, LE | 1 |
Adak, S; Aulak, KS; Stuehr, DJ | 1 |
Hurshman, AR; Marletta, MA | 1 |
Joseph, J; Kalyanaraman, B; Martásek, P; Vásquez-Vivar, J; Whitsett, J | 1 |
Tóth, M | 1 |
Torreilles, F; Touchon, J | 1 |
Ishii, M; Kiuchi, Y; Shimizu, S; Shiota, K; Yamamoto, S; Yamamoto, T | 1 |
Himi, N; Hirano, K; Kajiya, F; Miyasaka, T; Mochizuki, S; Nakamoto, H; Ogasawara, Y; Takemoto, M; Tsujioka, K | 1 |
Gorren, AC; Mayer, B; Schmidt, K | 1 |
Boucher, JL; Mansuy, D | 1 |
McDonald, JF; Meade, AL; Stuehr, DJ; Wang, ZQ; Wei, CC | 1 |
Marks, N; Wolff, DJ | 1 |
Arvai, AS; Getzoff, ED; Hemann, C; Hille, R; Stuehr, DJ; Wang, ZQ; Wei, CC | 1 |
Fujii, S; Igarashi, J; Kosaka, H; Yamamoto, A; Yoneyama, H; Zhang, L | 1 |
Boucher, JL; Desbois, A; Frapart, Y; Gorren, AC; Lefèvre-Groboillot, D; Mansuy, D; Mayer, B; Stuehr, DJ; Zimmermann, JL | 1 |
Ishii, M; Kiuchi, Y; Miyasaka, Y; Mori, Y; Nishida, M; Shimizu, S; Shiota, K; Watabe, T; Yamamoto, S; Yamamoto, T | 1 |
Ghosh, S; Mukherjee, S; Regulski, M; Sahoo, R; Sengupta, R; Stuehr, DJ; Tully, T | 1 |
Benchetrit, S; Bernheim, J; Podjarny, E; Pomeranz, A; Rashid, G; Rathaus, M; Shapira, J | 1 |
Sagami, I; Sato, Y; Shimizu, T | 1 |
Hemann, C; Hille, R; Stuehr, DJ; Wang, ZQ; Wei, CC | 1 |
Edmondson, DE; Hurshman, AR; Krebs, C; Marletta, MA | 1 |
Berka, V; Palmer, G; Tsai, AL; Wu, G; Yeh, HC | 1 |
Kurabayashi, M; Morita, H; Nagai, R; Nakamura, T; Saito, Y | 1 |
Hirata, Y | 1 |
Boucher, JL; Brunet, A; David-Dufilho, M; Devynck, MA; Millanvoye, E; Rendu, F; Topal, G | 1 |
deBlois, D; Der Sarkissian, S; Duguay, D; Marchand, EL | 1 |
Kotsonis, P; Matter, H | 1 |
Bernheim, J; Green, J; Hasdan, G; Korzets, Z; Podjarny, E; Rashid, G | 1 |
Bauersachs, J; Schäfer, A | 1 |
Feelisch, M; Reif, A; Schmidt, HH; Shutenko, ZV | 1 |
Cherian, L; Hlatky, R; Robertson, CS | 1 |
Berka, V; Gao, D; Kiran, F; Tsai, AL; Yeh, HC | 1 |
Ayajiki, K; Okamura, T; Shinozaki, K | 1 |
Cardounel, AJ; Xia, Y; Zweier, JL | 1 |
Durra, D; Garcin, ED; Getzoff, ED; Hemann, C; Hille, R; Stuehr, DJ; Wang, ZQ; Wei, CC | 1 |
Panda, K; Santolini, J; Stuehr, DJ; Wang, Q; Wang, ZQ; Wei, CC | 1 |
Jáchymová, M; Kalyanaraman, B; Martásek, P; Porter, R; Vásquez-Vivar, J | 1 |
Arteaga, E; Black, SM; Chace, DH; Fink, R; Ravi, K; Wainwright, MS | 1 |
Kajiya, F; Kashihara, N; Kimoto, M; Miyasaka, T; Mochizuki, S; Ogasawara, Y; Ono, J; Yada, T | 1 |
Black, SM; Farrow, KN; Jenkins, C; Konduri, GG; Lakshminrusimha, S; Mata-Greenwood, E; Russell, JA; Steinhorn, RH | 1 |
Bryan, RM; Durante, W; Jiang, X; Liao, D; Randhawa, JK; Rumbaut, RE; Schafer, AI; Tan, H; Wang, H; Yang, F; Yang, X | 1 |
Bevers, LM; Braam, B; Joles, JA; Koomans, HA; Post, JA; Rabelink, TJ; van Zonneveld, AJ; Verhaar, MC | 1 |
Boucher, JL; Lefèvre-Groboillot, D; Mansuy, D; Stuehr, DJ | 1 |
Andersson, KK; Gorren, AC; Lange, R; Marchal, S; Mayer, B; Sørlie, M | 1 |
Deng, H; Hayden, EY; Li, D; Panda, K; Rousseau, DL; Stuehr, DJ; Yeh, SR | 1 |
Abu-Soud, HM; Diamond, MP; Saed, GM; Zhao, M | 1 |
Hiroi, T; Ishii, M; Kiuchi, Y; Shimizu, S; Wajima, T | 1 |
Corti, R; Flammer, A; Hermann, F; Lüscher, TF; Noll, G; Spieker, LE; Sudano, I | 1 |
Gorren, AC; Mayer, B; Nedeianu, S; Pignitter, M; Schmidt, K | 1 |
Hillier, IH; Joule, JA; Morao, I; Periyasamy, G | 1 |
Fekkes, D; Hoekstra, R; Loonen, AJ; Pepplinkhuizen, L; Tuinier, S; Verhoeven, WM | 1 |
Ayajiki, K; Gemba, M; Okamura, T; Shinozaki, K; Yamamizu, K | 1 |
Gao, YT; Ishimura, Y; Martásek, P; Masters, BSS; Panda, SP; Roman, LJ | 1 |
Akasaka, T; Kaji, S; Kajiya, F; Mochizuki, S; Ogasawara, Y; Tanemoto, K; Yada, T; Yoshida, K | 1 |
Bhattacharjee, A; Dutta, T; Ghosh, S; Ray, SS; Regulski, M; Stuehr, DJ; Tejero, J; Tully, T; Wang, ZQ | 1 |
Berka, V; Tsai, AL; Wang, LH | 1 |
Behnke, BJ; Delp, MD; Muller-Delp, JM; Spier, SA; Wu, G | 1 |
Hemann, C; Hille, R; Stuehr, DJ; Tejero, J; Wang, ZQ; Wei, CC; Yang, YP | 1 |
Heffernan, KS; Valentine, RJ; Vieira, VJ | 1 |
Cardounel, AJ; Chen, CA; Druhan, LJ; Forbes, SP; Pope, AJ; Zweier, JL | 1 |
Datta, S; Kim, SW; Li, P; Li, X; Pond, WG; Wu, G | 1 |
Christensen, JC; Fleck, JD; Glaser, C; Hyland, K; Martin, KW; Roy-Burman, A; Rupprecht, CE; Westenkirschner, DF; Willoughby, RE | 1 |
Biswas, A; Haque, MM; Hemann, C; Misra, S; Page, RC; Stuehr, DJ; Tejero, J; Wang, ZQ; Zweier, JL | 1 |
Böhm, F; Channon, KM; Malmström, RE; Pernow, J; Settergren, M | 1 |
Bommassar, C; Golderer, G; Gröbner, P; Leitner, S; Messner, S; Werner, ER; Werner-Felmayer, G | 1 |
Boucher, JL; Fournet-Bourguignon, MP; Frapart, Y; Gosgnach, W; Lesage, L; Molez, S; Perrier, E; Reure, H; Royere, E; Vilaine, JP; Villeneuve, N | 1 |
Boontje, NM; de Crom, R; de Waard, MC; Dekkers, DH; Duncker, DJ; Kuster, DW; Lamers, JM; van der Velden, J; van Haperen, R | 1 |
Davidge, ST; Sankaralingam, S; Xu, H | 1 |
Deutz, NE; Engelen, MP; Luiking, YC | 1 |
Daneshtalab, N; Smeda, JS | 1 |
Arellano-Mendoza, MG; Castorena-Torres, F; Coronel, I; del Valle-Mondragon, L; Escalante, B; Rios, A; Romo, E; Vargas-Robles, H | 1 |
Boegehold, MA; Li, P; Nurkiewicz, TR; Wu, G | 1 |
Förstermann, U | 1 |
Delgado, C; Ruiz-Hurtado, G | 1 |
Gielis, JF; Lin, JY; Moens, AL; Schmidt, HH; Van Schil, PE; Wingler, K | 1 |
Bonilla, I; Cardounel, AJ; Carnes, CA; Elton, TS; Györke, S; Khan, M; Kuppusamy, P; Li, C; Nishijima, Y; Sridhar, A; Terentyev, D; Terentyeva, R; Velayutham, M; Zweier, JL | 1 |
Holowatz, LA; Kenney, WL | 1 |
Förstermann, U; Sessa, WC | 1 |
Boucher, JL; Mansuy, D; Salard-Arnaud, I; Stuehr, D | 1 |
Boegehold, MA; Kang, LS; Nurkiewicz, TR; Wu, G | 1 |
Biswas, A; Fadlalla, M; Haque, MM; Santolini, J; Stuehr, DJ; Tejero, J; Wang, ZQ; Wei, CC | 1 |
Bino, L; Kadlec, J; Klinke, A; Kubala, L; Kuchta, R; Lau, D; Lojek, A; Martiskova, H; Pekarova, M; Vasicek, O; Vrba, R | 1 |
Messina, LM; Tie, G; Yan, J | 2 |
Bernad, S; Brunel, A; Dorlet, P; Santolini, J; Sicard-Roselli, C | 1 |
Benedito, S; Climent, B; Contreras, C; García-Sacristán, A; Hernández, M; Martínez, MP; Prieto, D; Sánchez, A | 1 |
Aramburo, A; Black, SM; Fineman, JR; Kalkan, G; Kallarackal, S; Kumar, S; Rafikov, R; Rehmani, I; Sharma, S; Sun, X; Tian, J | 1 |
Choi, YH; Noh, JS; Song, YO | 1 |
Brunel, A; Dorlet, P; Santolini, J | 1 |
Fung, HL; Mohan, S | 1 |
Hoang, HH; Meininger, CJ; Padgham, SV | 1 |
Beatty, KM; Chen, AF; Ghosh, A; Li, F; Liu, H; McKenna, KC; Scherder, RC; Stuehr, DJ | 1 |
Stuehr, D; Tejero, J | 1 |
Ghosh, A; Haque, MM; Mukherjee, N; Nagpal, L; Panda, K; Ranu, BC; Saha, A; Stuehr, DJ | 1 |
Cottin, Y; Guilland, JC; Lorin, J; Rochette, L; Vergely, C; Zeller, M | 1 |
Bange, FC; Georgieva, M; Jung, JY; Madan-Lala, R; Rengarajan, J; Robinson, CM; Sohaskey, CD | 1 |
Bergmeister, H; Bonderman, D; Jakowitsch, J; Lang, IM; Mascherbauer, J; Panzenböck, A; Schreiber, C; Strobl, M; Wexberg, P; Winter, MP | 1 |
Adamo, RF; Alferiev, IS; Chorny, M; Fishbein, I; Forbes, SP; Levy, RJ | 1 |
Böhm, F; Channon, KM; Gonon, AT; Kiss, A; Pernow, J; Settergren, M; Sjöquist, PO; Tornvall, P; Tratsiakovich, Y; Yang, J | 1 |
Bayatli, N; Gur, S; Kaya, E; Un, O; Yilmaz, D | 1 |
Aguayo, C; Avila, P; Cabrera, L; Gallardo, V; González, M; Guzmán-Gutiérrez, E; Leiva, A; Palma, C; Pardo, F; Peña, E; Rojas, S; Sáez, T; Salsoso, R; Sanhueza, C; Sobrevia, L; Villalobos, R | 1 |
Chen, W; Harbeck, MC; He, D; Peng, H; Xie, L; Zhuang, Y | 1 |
Fuenzalida, B; Gutiérrez, J; Leiva, A; Pardo, F; Salomón, C; Sanhueza, C; Sobrevia, L; Toledo, F; Westermeier, F | 1 |
Ackerman, HC; Alkaitis, MS | 1 |
Gangoda, M; Haque, MM; Ramasamy, S; Stuehr, DJ | 1 |
Belfield, G; Lewis, R; Narjes, F; Öberg, L; Ripa, L; Shamovsky, I; Sjö, P; Tyrchan, C | 1 |
Aguiar, AS; da Luz Scheffer, D; de Bortoli da Silva, L; de Matos, FJ; de Oliveira, PA; de Paula Martins, R; Gabach, L; Ghersi, M; Ghisoni, K; Lanfumey, L; Latini, A; Mongeau, R; Nesi, RT; Pérez, MF; Pires, ACS; Prediger, RD; Raisman-Vozari, R; Rubiales-Barioglio, S | 1 |
Awasthi, D; Chandra, T; Dikshit, M; Jagavelu, K; Kumar, S; Nagarkoti, S; Sadaf, S | 1 |
Aschner, JL; Cunningham, G; Dikalova, A; Fike, CD; Kaplowitz, MR; Summar, M | 1 |
Fernando, V; Furuta, S; Letson, J; Sharma, V; Walia, Y; Zheng, X | 1 |
Albrecht, J; Czarnecka, AM; Milewski, K; Zielińska, M | 1 |
Degrush, E; Drachman, D; Gounis, MJ; Henninger, N; Lindsay, C; Shazeeb, MS; Vardar, Z | 1 |
Reviews
30 review(s) available for arginine and sapropterin
Article | Year |
---|---|
Role of tetrahydrobiopterin in cytokine-stimulated metabolism of tryptophan and hydroxylation of arginine.
Topics: Animals; Arginine; Biopterins; Cell Line; Cells, Cultured; Cytokines; Humans; Hydroxylation; Interferon-gamma; Macrophages; Mice; Mice, Inbred C57BL; Models, Biological; Monocytes; Nitric Oxide; Pterins; Skin; Tryptophan; Tumor Necrosis Factor-alpha | 1993 |
Therapeutic strategies for the inhibition of inducible nitric oxide synthase--potential for a novel class of anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Arginine; Biopterins; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glucocorticoids; Humans; Immunosuppressive Agents; Nitric Oxide; Nitric Oxide Synthase; Transcription Factors | 1996 |
Cellular and molecular mechanisms of endothelial cell dysfunction.
Topics: Arginase; Arginine; Biopterins; Endothelium, Vascular; Humans; NAD; NADP; Nitric Oxide; Nitric Oxide Synthase; Superoxides | 1997 |
Catalysis by nitric oxide synthase.
Topics: Antioxidants; Arginine; Biopterins; Catalysis; Citrulline; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Heme; Hydrogen Peroxide; Isoenzymes; Nitric Oxide; Nitric Oxide Synthase | 1998 |
A new decoration for nitric oxide synthase - a Zn(Cys)4 site.
Topics: Animals; Arginine; Binding Sites; Biopterins; Citrulline; Cysteine; Dimerization; Electron Transport; Macromolecular Substances; Models, Molecular; NADP; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Protein Conformation; Zinc | 1999 |
Nitric oxide biosynthesis, nitric oxide synthase inhibitors and arginase competition for L-arginine utilization.
Topics: Animals; Arginase; Arginine; Biopterins; Calcium; Calmodulin; Electron Transport; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Free Radicals; Humans; Isoenzymes; Mice; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase | 1999 |
Tetrahydrobiopterin and endothelial nitric oxide synthase activity.
Topics: Antioxidants; Arginine; Biopterins; Citrulline; Coronary Vessels; Endothelium, Vascular; Enzyme Activation; Humans; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Vascular Diseases | 1999 |
Enzymatic function of nitric oxide synthases.
Topics: Animals; Antioxidants; Arginine; Biopterins; Calcium; Calmodulin; Dimerization; Endothelium, Vascular; Enzyme Activation; Heme; Humans; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III | 1999 |
Current strategies and perspectives for correcting endothelial dysfunction in atherosclerosis.
Topics: Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxidants; Arginine; Aspirin; Biopterins; Calcium Channel Blockers; Coronary Artery Disease; Endothelins; Endothelium, Vascular; Folic Acid; Hormone Replacement Therapy; Humans; Nitrates; Nitric Oxide; Nitric Oxide Synthase | 2001 |
[Role of tetrahydrobiopterin in the regulation of activity of human placental nitric oxide synthase in normal and pre-eclamptic pregnancies].
Topics: Arginine; Biopterins; Cytosol; Female; Humans; Nitric Oxide Synthase; Placenta; Pre-Eclampsia; Pregnancy | 2002 |
Pathogenic theories and intrathecal analysis of the sporadic form of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Arginine; Biopterins; Brain; Brain Chemistry; Calcium; Cerebrospinal Fluid; Cerebrospinal Fluid Proteins; Humans; Inflammation; Isoenzymes; Models, Biological; Nerve Degeneration; Nerve Growth Factors; Nerve Tissue Proteins; Neurofibrillary Tangles; Nitric Oxide Synthase; Oxidative Stress; Peroxynitrous Acid; Phosphorylation; Protein Processing, Post-Translational; Synaptic Transmission; tau Proteins | 2002 |
Oxidation of N-hydroxyguanidines by cytochromes P450 and NO-synthases and formation of nitric oxide.
Topics: Arginine; Biopterins; Cytochrome P-450 Enzyme System; Guanidines; Hydroxylamines; Nitric Oxide; Nitric Oxide Synthase; Nitrogen; Oxidation-Reduction; Substrate Specificity | 2002 |
[Structure-function relationships of NO synthase: electron transfer reaction].
Topics: Animals; Arginine; Binding Sites; Biopterins; Calmodulin; Crystallization; Electron Transport; Heme; Humans; Iron; Nitric Oxide; Nitric Oxide Synthase; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Structure-Activity Relationship; Sulfhydryl Compounds | 2003 |
[Involvement of homocysteine in the pathogenesis of hypertension and hypertensive target-organ damage].
Topics: Arginine; Arteriosclerosis; Biopterins; Cell Division; Endothelium, Vascular; Folic Acid; Homocysteine; Humans; Hypertension; Insulin Resistance; Muscle, Smooth, Vascular; Nitric Oxide; Oxidative Stress; Risk Factors | 2004 |
[NO and hypertension].
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Arginine; Arteriosclerosis; Biopterins; C-Reactive Protein; Endothelium, Vascular; Humans; Hypertension; Mutation; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Perindopril; Reactive Oxygen Species; Vasodilation | 2004 |
Biology and chemistry of the inhibition of nitric oxide synthases by pteridine-derivatives as therapeutic agents.
Topics: Animals; Arginine; Binding Sites; Biopterins; Brain Ischemia; Enzyme Inhibitors; Humans; Inflammation; Isoenzymes; Neurodegenerative Diseases; Nitric Oxide Synthase; Protein Conformation; Pteridines; Quantitative Structure-Activity Relationship; Sepsis; Structure-Activity Relationship | 2004 |
Endothelial dysfunction in heart failure: mechanisms and therapeutic approaches.
Topics: Animals; Antioxidants; Arginine; Biopterins; Disease Models, Animal; Endothelins; Endothelium, Vascular; Exercise; Genetic Therapy; Heart Failure; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Renin-Angiotensin System | 2004 |
[Mechanisms of nitric oxide production].
Topics: Arginine; Biopterins; Calcium; Calmodulin; Cyclic GMP; Guanylate Cyclase; Humans; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Phosphorylation; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Transcription, Genetic | 2004 |
High-pressure studies of the reaction mechanism of nitric-oxide synthase.
Topics: Animals; Arginine; Biopterins; Catalysis; Humans; Nitric Oxide; Nitric Oxide Synthase; Pressure; Temperature | 2006 |
Protection of endothelial function: targets for nutritional and pharmacological interventions.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Arginine; Atherosclerosis; Biopterins; Cacao; Calcium Channel Blockers; Cyclooxygenase Inhibitors; Dyslipidemias; Endothelin-1; Endothelins; Endothelium, Vascular; Flavonoids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipoproteins, HDL; Nitric Oxide; Oxidative Stress; Reactive Oxygen Species | 2006 |
Microvascular function and ageing L-arginine, tetrahydrobiopterin and the search for the fountain of vascular youth.
Topics: Aging; Animals; Arginine; Arterioles; Biopterins; Endothelium, Vascular; Muscle, Skeletal; Rats; Vasodilation | 2008 |
Regulation of nitric oxide production in health and disease.
Topics: Animals; Arginase; Arginine; Ascorbic Acid; Biopterins; Citrulline; Diet; Dietary Fats; Endothelium; Humans; Hypertension; Mice; Nitric Oxide; Nitric Oxide Synthase Type III; Sepsis | 2010 |
Nitric oxide and oxidative stress in vascular disease.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxidants; Arginine; Aryldialkylphosphatase; Biopterins; Calcium; Cardiovascular Diseases; Catalase; Electron Transport; Glutathione Peroxidase; Heme Oxygenase (Decyclizing); Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mitochondria; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphorylation; Protein Multimerization; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Risk Factors; Superoxide Dismutase; Superoxides; Thioredoxins; Vascular Diseases; Xanthine Oxidase | 2010 |
Nitric oxide pathway in hypertrophied heart: new therapeutic uses of nitric oxide donors.
Topics: Arginine; Biopterins; Cardiomegaly; Cyclic GMP; Humans; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase | 2010 |
Pathogenetic role of eNOS uncoupling in cardiopulmonary disorders.
Topics: Arginine; Atherosclerosis; Biopterins; Blood Pressure; Cardiac Surgical Procedures; Cell Adhesion; Endothelium, Vascular; Folic Acid; Humans; Hypertension, Pulmonary; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Oxidation-Reduction; Oxygen; Reactive Oxygen Species; Vasodilation; Ventricular Remodeling | 2011 |
Nitric oxide synthases: regulation and function.
Topics: Animals; Arginine; Biopterins; Cardiovascular Agents; Cardiovascular Diseases; Endothelium, Vascular; Genetic Therapy; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isoenzymes; Mice; Neovascularization, Physiologic; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III | 2012 |
L-arginine, tetrahydrobiopterin, nitric oxide and diabetes.
Topics: Arginine; Biomarkers; Biopterins; Cardiovascular Diseases; Diabetes Mellitus; Endothelium, Vascular; Homeostasis; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Tetrahydrofolate Dehydrogenase | 2013 |
Tetrahydrobiopterin in nitric oxide synthase.
Topics: Amino Acid Oxidoreductases; Arginine; Biopterins; Catalysis; Heme; Nitric Oxide; Nitric Oxide Synthase | 2013 |
Arginine and nitric oxide synthase: regulatory mechanisms and cardiovascular aspects.
Topics: Adipose Tissue; Arginine; Biological Transport; Biopterins; Cardiovascular Diseases; Cardiovascular System; Citrulline; Diet; Dietary Supplements; Humans; Nitric Oxide Synthase | 2014 |
Role for Tetrahydrobiopterin in the Fetoplacental Endothelial Dysfunction in Maternal Supraphysiological Hypercholesterolemia.
Topics: Animals; Arginine; Biopterins; Borohydrides; Cholesterol; Endothelium, Vascular; Female; Humans; Hypercholesterolemia; Nitric Oxide; Nitric Oxide Synthase Type III; Pregnancy | 2015 |
Trials
3 trial(s) available for arginine and sapropterin
Article | Year |
---|---|
Tetrahydrobiopterin restores endothelial function in hypercholesterolemia.
Topics: Adult; Antioxidants; Arginine; Biopterins; Endothelium; Female; Forearm; Humans; Hypercholesterolemia; Male; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Plethysmography; Serotonin; Vasoconstriction; Vasodilation | 1997 |
L-arginine and tetrahydrobiopterin protects against ischemia/reperfusion-induced endothelial dysfunction in patients with type 2 diabetes mellitus and coronary artery disease.
Topics: Aged; Arginine; Biopterins; Blood Flow Velocity; Cardiovascular Agents; Coronary Artery Disease; Cross-Over Studies; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Therapy, Combination; Endothelium, Vascular; Female; Forearm; Humans; Infusions, Intra-Arterial; Male; Regional Blood Flow; Reperfusion Injury; Treatment Outcome; Vasodilation; Vasodilator Agents | 2009 |
Acute localized administration of tetrahydrobiopterin and chronic systemic atorvastatin treatment restore cutaneous microvascular function in hypercholesterolaemic humans.
Topics: Anticholesteremic Agents; Arginase; Arginine; Atorvastatin; Biopterins; Cholesterol; Female; Heating; Heptanoic Acids; Humans; Hypercholesterolemia; Lipoproteins, LDL; Male; Microcirculation; Microdialysis; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Pyrroles; Regional Blood Flow; Skin; Vasodilation | 2011 |
Other Studies
197 other study(ies) available for arginine and sapropterin
Article | Year |
---|---|
Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle.
Topics: Amino Acid Oxidoreductases; Animals; Aorta; Arginine; Biopterins; Cells, Cultured; Cytosol; Hypoxanthines; Interferon-gamma; Kinetics; Lipopolysaccharides; Male; Methotrexate; Muscle, Smooth, Vascular; Myoglobin; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Oxidation-Reduction; Oxygen Consumption; Pteridines; Pterins; Rats; Rats, Inbred F344; Recombinant Proteins | 1992 |
Pterins inhibit nitric oxide synthase activity in rat alveolar macrophages.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Cells, Cultured; Citrulline; Hypoxanthines; Interferon-gamma; Macrophages, Alveolar; Male; Nitric Oxide Synthase; Nitrites; Pteridines; Pterins; Rats; Rats, Wistar; Recombinant Proteins | 1992 |
Nitric oxide synthase-catalyzed activation of oxygen and reduction of cytochromes: reaction mechanisms and possible physiological implications.
Topics: Amino Acid Oxidoreductases; Arginine; Biopterins; Cerebellum; Cytochrome c Group; Electron Transport; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Hydrogen Peroxide; NADH Dehydrogenase; NADP; Nitric Oxide Synthase; Oxidation-Reduction; Oxygen | 1992 |
Tetrahydrobiopterin induces vasodilation via enhancement of cGMP level.
Topics: Animals; Aorta, Thoracic; Arginine; Biopterins; Cyclic GMP; In Vitro Techniques; Methoxamine; Muscle Contraction; NG-Nitroarginine Methyl Ester; Radioimmunoassay; Rats; Vasodilation | 1992 |
(6R)-5,6,7,8-tetrahydro-L-biopterin modulates nitric oxide-associated soluble guanylate cyclase activity in the rat cerebellum.
Topics: Animals; Arginine; Biopterins; Calcium; Calmodulin; Cerebellum; Cytosol; Guanylate Cyclase; Kinetics; Male; NADP; Nitric Oxide; Nitroprusside; Rats; Rats, Wistar | 1992 |
Ca2+/calmodulin-dependent formation of hydrogen peroxide by brain nitric oxide synthase.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Binding, Competitive; Biopterins; Brain; Calcium; Calmodulin; Citrulline; Hydrogen Peroxide; NADP; Nitric Oxide Synthase; Nitroarginine; omega-N-Methylarginine; Swine | 1992 |
Identification and characterization of a calmodulin-dependent nitric oxide synthase from GH3 pituitary cells.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Autoradiography; Biopterins; Blotting, Western; Brain; Calmodulin; Cattle; Cells, Cultured; Chromatography, DEAE-Cellulose; Citrulline; Enzyme Activation; Kinetics; NADH Dehydrogenase; Nitric Oxide Synthase; Nitroarginine; Nitroblue Tetrazolium; omega-N-Methylarginine; Pituitary Gland | 1992 |
Inducible but not constitutive production of nitric oxide by vascular smooth muscle cells.
Topics: Animals; Arginine; Biopterins; Calcium; Calmodulin; Cells, Cultured; Cyclic CMP; Lipopolysaccharides; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats | 1991 |
Induction of nitric oxide synthase by cytokines in vascular smooth muscle cells.
Topics: Amino Acid Oxidoreductases; Animals; Aorta, Thoracic; Arginine; Biopterins; Cells, Cultured; Cyclic GMP; Cytokines; Enzyme Induction; In Vitro Techniques; Interferon-gamma; Interleukin-1; Muscle, Smooth, Vascular; NADP; Nitric Oxide; Nitric Oxide Synthase; Rabbits; Tumor Necrosis Factor-alpha | 1990 |
Tetrahydrobiopterin, a cofactor for rat cerebellar nitric oxide synthase, does not function as a reactant in the oxygenation of arginine.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Cerebellum; Chromatography, Affinity; Chromatography, Ion Exchange; Kinetics; Male; Methotrexate; Nitric Oxide Synthase; Protein Binding; Rats; Rats, Inbred Strains | 1991 |
Cytokine-activated endothelial cells express an isotype of nitric oxide synthase which is tetrahydrobiopterin-dependent, calmodulin-independent and inhibited by arginine analogs with a rank-order of potency characteristic of activated macrophages.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Brain; Calmodulin; Cells, Cultured; Cycloheximide; Cytokines; Endothelium, Vascular; Interferon-gamma; Isoenzymes; Kinetics; Macrophage Activation; Macrophages; Mice; Nitric Oxide; Nitric Oxide Synthase; Pteridines; Pterins; Recombinant Proteins; Tumor Necrosis Factor-alpha | 1991 |
Brain nitric oxide synthase is a biopterin- and flavin-containing multi-functional oxido-reductase.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Calcium; Calmodulin; Cerebellum; Citrulline; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Hydrogen Peroxide; Kinetics; NADP; Nitric Oxide; Nitric Oxide Synthase; Spectrophotometry; Swine | 1991 |
Characterization of nitric oxide synthases in non-adrenergic non-cholinergic nerve containing tissue from the rat anococcygeus muscle.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Calcium; Citrulline; Endothelium, Vascular; In Vitro Techniques; Male; Muscles; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Inbred Strains; Vas Deferens | 1991 |
Macrophage oxidation of L-arginine to nitric oxide, nitrite, and nitrate. Tetrahydrobiopterin is required as a cofactor.
Topics: Animals; Arginine; Biopterins; Cell Line; Chromatography, High Pressure Liquid; Citrulline; Cytosol; Kinetics; Macrophages; NADP; Nitrates; Nitric Oxide; Nitrites; Oxidation-Reduction | 1989 |
Inducible nitric oxide synthase activity in hepatocytes is dependent on the coinduction of tetrahydrobiopterin synthesis.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Cells, Cultured; Cytokines; Enzyme Induction; Gene Expression; GTP Cyclohydrolase; Hypoxanthines; Lipopolysaccharides; Liver; Methotrexate; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; RNA, Messenger | 1993 |
Nitric oxide inhibits neuronal nitric oxide synthase by interacting with the heme prosthetic group. Role of tetrahydrobiopterin in modulating the inhibitory action of nitric oxide.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Carbon Monoxide; Cerebellum; Citrulline; Cyanides; Heme; NADP; Neurons; Nitric Oxide; Nitric Oxide Synthase; Oxidants; Oxyhemoglobins; Rats; Sulfhydryl Compounds; Superoxide Dismutase | 1994 |
Identification of imidazole as L-arginine-competitive inhibitor of porcine brain nitric oxide synthase.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Binding Sites; Binding, Competitive; Biopterins; Brain; Imidazoles; In Vitro Techniques; Nitric Oxide Synthase; Swine | 1994 |
Hepatocyte inducible nitric oxide synthesis is influenced in vitro by cell density.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Cell Count; Cells, Cultured; Cyclic GMP; Cytokines; Humans; Lipopolysaccharides; Liver; Male; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1994 |
A bacterial nitric oxide synthase from a Nocardia species.
Topics: Amino Acid Oxidoreductases; Arginine; Biopterins; Calcium; Citrulline; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; NADP; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nocardia; Oxygen | 1994 |
Stimulation of IRE-BP activity of IRF by tetrahydrobiopterin and cytokine dependent induction of nitric oxide synthase.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Cell Line; Chloramphenicol O-Acetyltransferase; Deferoxamine; Humans; Interferon-gamma; Iron; Iron-Regulatory Proteins; Kinetics; Leukemia, Myeloid, Acute; Lipopolysaccharides; Macrophages; Mice; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; RNA Probes; RNA-Binding Proteins; Transfection; Tumor Cells, Cultured | 1994 |
N-nitro-L-arginine and N-monomethyl-L-arginine exhibit a different pattern of inactivation toward the three nitric oxide synthases.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Binding Sites; Biopterins; Brain; In Vitro Techniques; Isoenzymes; Kinetics; Male; Models, Biological; Nitric Oxide Synthase; Nitroarginine; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley | 1995 |
Tetrahydrobiopterin deficiency and brain nitric oxide synthase in the hph1 mouse.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Brain; GTP Cyclohydrolase; Kinetics; Metabolism, Inborn Errors; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mutation; Nitric Oxide Synthase | 1995 |
Structural analysis of porcine brain nitric oxide synthase reveals a role for tetrahydrobiopterin and L-arginine in the formation of an SDS-resistant dimer.
Topics: Allosteric Regulation; Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Brain Chemistry; Hot Temperature; Neurons; Nitric Oxide Synthase; Protein Conformation; Protein Folding; Protein Structure, Secondary; Sodium Dodecyl Sulfate; Swine | 1995 |
Thiol dependence of nitric oxide synthase.
Topics: Animals; Arginine; Biopterins; Cerebellum; Citrulline; Kinetics; NADP; Nitric Oxide Synthase; Rats; Structure-Activity Relationship; Sulfhydryl Compounds; Swine | 1995 |
Regulation of the L-arginine-dependent and tetrahydrobiopterin-dependent biosynthesis of nitric oxide in murine macrophages.
Topics: Alcohol Oxidoreductases; Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Cells, Cultured; Cytosol; Dexamethasone; GTP Cyclohydrolase; Hypoxanthines; Macrophages; Mice; Mice, Inbred C3H; Nitric Oxide; Nitric Oxide Synthase; Phenprocoumon | 1993 |
Multiple catalytic functions of brain nitric oxide synthase. Biochemical characterization, cofactor-requirement, and the role of N omega-hydroxy-L-arginine as an intermediate.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Brain; Catalysis; Coenzymes; Heme; Hydrolysis; Kinetics; NADP; Nitric Oxide Synthase; Oxidation-Reduction; Substrate Specificity; Swine | 1993 |
Tetrahydrobiopterin-dependent nitrite oxidation to nitrate in isolated rat hepatocytes.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Cells, Cultured; Cytosol; Humans; Interleukin-1; Kinetics; Lipopolysaccharides; Liver; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; omega-N-Methylarginine; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Tumor Necrosis Factor-alpha | 1993 |
Coinduction of nitric oxide synthesis and intracellular nonheme iron-nitrosyl complexes in murine cytokine-treated fibroblasts.
Topics: Animals; Arginine; Biopterins; Cytokines; Electron Spin Resonance Spectroscopy; Escherichia coli; Ferric Compounds; Fibroblasts; Hypoxanthines; Interferon-gamma; Iron; Lipopolysaccharides; Mice; Nitric Oxide; omega-N-Methylarginine; Recombinant Proteins; Tumor Necrosis Factor-alpha | 1994 |
Mutation in the 4a-carbinolamine dehydratase gene leads to mild hyperphenylalaninemia with defective cofactor metabolism.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acid Sequence; Arginine; Base Sequence; Biopterins; Cysteine; DNA Mutational Analysis; DNA-Binding Proteins; Gene Expression Regulation, Enzymologic; Hepatocyte Nuclear Factor 1; Hepatocyte Nuclear Factor 1-alpha; Hepatocyte Nuclear Factor 1-beta; Humans; Hydro-Lyases; Infant; Male; Molecular Sequence Data; Nuclear Proteins; Pedigree; Phenylalanine; Phenylketonurias; Point Mutation; Transcription Factors | 1993 |
Conditions required for the measurement of nitric oxide synthase activity in a myenteric plexus/smooth muscle preparation from the rat ileum.
Topics: Animals; Antioxidants; Arginine; Biopterins; Calcium; Calmodulin; Citrulline; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Ileum; In Vitro Techniques; Muscle, Smooth; Myenteric Plexus; NADP; Nitric Oxide Synthase; Rats; Rats, Wistar | 1995 |
Intracellular assembly of inducible NO synthase is limited by nitric oxide-mediated changes in heme insertion and availability.
Topics: Aminolevulinic Acid; Animals; Arginine; Biopterins; Cell Line; Cytokines; Enzyme Induction; Enzyme Inhibitors; Heme; Homeostasis; Interferon-gamma; Iron; Isoenzymes; Kinetics; Lipopolysaccharides; Macromolecular Substances; Macrophage Activation; Macrophages; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Recombinant Proteins; Time Factors | 1996 |
Endothelial nitric-oxide synthase. Expression in Escherichia coli, spectroscopic characterization, and role of tetrahydrobiopterin in dimer formation.
Topics: Animals; Arginine; Biopterins; Cattle; Chromatography, Affinity; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Heme; Histidine; Kinetics; Macromolecular Substances; Molecular Weight; Nitric Oxide Synthase; Protein Denaturation; Recombinant Proteins; Restriction Mapping; Sequence Tagged Sites; Spectrophotometry; Substrate Specificity | 1996 |
Reduction of quinonoid dihydrobiopterin to tetrahydrobiopterin by nitric oxide synthase.
Topics: Animals; Arginine; Biopterins; Cell Line; Cerebellum; Enzyme Inhibitors; Humans; Indazoles; Kidney; Kinetics; Methotrexate; NADP; Nitric Oxide Synthase; Nitroarginine; Onium Compounds; Oxidation-Reduction; Rats; Recombinant Proteins; Transfection | 1996 |
Characterization of heme-deficient neuronal nitric-oxide synthase reveals a role for heme in subunit dimerization and binding of the amino acid substrate and tetrahydrobiopterin.
Topics: Animals; Arginine; Binding Sites; Biopterins; Brain; Chromatography, Gel; Circular Dichroism; Citrulline; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Heme; Isoenzymes; Light; Macromolecular Substances; Neurons; Nitric Oxide Synthase; Nitroarginine; Protein Conformation; Protein Structure, Secondary; Rats; Scattering, Radiation; Thermodynamics | 1996 |
Identification of the domains of neuronal nitric oxide synthase by limited proteolysis.
Topics: Amino Acid Sequence; Animals; Arginine; Binding Sites; Biopterins; Blotting, Western; Brain; Calmodulin; Chymotrypsin; Cytochrome c Group; Electrophoresis, Polyacrylamide Gel; Flavin Mononucleotide; Heme; Humans; Molecular Sequence Data; Molecular Weight; Nitric Oxide Synthase; Nitroarginine; Peptide Fragments; Rabbits; Rats; Recombinant Proteins; Trypsin | 1996 |
Role of tetrahydrobiopterin availability in the regulation of nitric-oxide synthase expression in human mesangial cells.
Topics: Arginine; Biopterins; Cells, Cultured; Enzyme Induction; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glomerular Mesangium; Humans; Interleukin-1; Kinetics; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitrites; Nitroprusside; Pteridines; Pterins; Recombinant Proteins; RNA, Messenger; Sugar Acids; Transcription, Genetic; Tumor Necrosis Factor-alpha | 1996 |
Overexpression of neuronal nitric oxide synthase in insect cells reveals requirement of haem for tetrahydrobiopterin binding.
Topics: Animals; Arginine; Baculoviridae; Biopterins; Brain; Citrulline; Culture Media; Flavins; Heme; Kinetics; Neurons; Nitric Oxide Synthase; Protein Processing, Post-Translational; Rats; Recombinant Proteins; Spodoptera; Tritium | 1996 |
Calcium-dependent nitric oxide synthesis is potently stimulated by tetrahydrobiopterin in human primordial placenta.
Topics: Arginine; Biopterins; Calcium; Citrulline; Enzyme Activation; Female; Humans; NADP; Nitric Oxide; Nitric Oxide Synthase; Placenta; Pregnancy | 1996 |
Active-site structure analysis of recombinant human inducible nitric oxide synthase using imidazole.
Topics: Arginine; Binding Sites; Biopterins; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Imidazoles; Isoenzymes; Kinetics; Molecular Structure; Nitric Oxide Synthase; Nitroarginine; Recombinant Proteins; Spectrophotometry; Structure-Activity Relationship | 1996 |
Glucocorticoids regulate inducible nitric oxide synthase by inhibiting tetrahydrobiopterin synthesis and L-arginine transport.
Topics: Animals; Arginine; Argininosuccinate Lyase; Argininosuccinate Synthase; Biological Transport; Biopterins; Cells, Cultured; Cytokines; Dexamethasone; Gene Expression Regulation, Enzymologic; Glucocorticoids; GTP Cyclohydrolase; Interferon-gamma; Interleukin-1; Male; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Rats; Rats, Sprague-Dawley; Recombinant Proteins | 1996 |
Nitrite generation in interleukin-4-treated human macrophage cultures does not involve the nitric oxide synthase pathway.
Topics: Amino Acids; Animals; Arginine; Biopterins; Cells, Cultured; Culture Media; Female; Humans; Interferon-gamma; Interleukin-4; Macrophages; Male; Muscle, Smooth, Vascular; Neopterin; Nitrates; Nitric Oxide Synthase; Nitrites; Oxidation-Reduction; Rats; Recombinant Proteins | 1997 |
Subunit interactions of endothelial nitric-oxide synthase. Comparisons to the neuronal and inducible nitric-oxide synthase isoforms.
Topics: Antioxidants; Arginine; Biopterins; Endothelium, Vascular; Enzyme Induction; Humans; Isoenzymes; Neurons; Nitric Oxide Synthase; Protein Conformation | 1997 |
Active site topologies and cofactor-mediated conformational changes of nitric-oxide synthases.
Topics: Animals; Arginine; Binding Sites; Biopterins; Calmodulin; Cattle; Imides; Imines; Iron; Nitric Oxide Synthase; Protein Conformation; Rats | 1997 |
Thiols and neuronal nitric oxide synthase: complex formation, competitive inhibition, and enzyme stabilization.
Topics: Animals; Arginine; Biopterins; Calmodulin; Cysteine; Dithiothreitol; Enzyme Inhibitors; Enzyme Stability; Flavin-Adenine Dinucleotide; Heme; Mercaptoethanol; NADP; Neurons; Nitric Oxide Synthase; Protein Binding; Rats; Spectrometry, Fluorescence; Spectrophotometry; Sulfhydryl Compounds; Temperature | 1997 |
Mutagenesis of acidic residues in the oxygenase domain of inducible nitric-oxide synthase identifies a glutamate involved in arginine binding.
Topics: Alanine; Amino Acid Sequence; Animals; Antioxidants; Arginine; Biopterins; Cattle; Chromatography, Gel; Glutamic Acid; Heme; Humans; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Nitric Oxide Synthase; Oxygenases; Rats; Structure-Activity Relationship | 1997 |
Delineation of the arginine- and tetrahydrobiopterin-binding sites of neuronal nitric oxide synthase.
Topics: Amino Acid Sequence; Animals; Antioxidants; Arginine; Binding Sites; Biopterins; Calorimetry; Escherichia coli; Heme; Humans; Mice; Molecular Sequence Data; Neurons; Nitric Oxide Synthase; Peptide Mapping; Rats; Sequence Alignment; Structure-Activity Relationship | 1997 |
The ferrous-dioxy complex of neuronal nitric oxide synthase. Divergent effects of L-arginine and tetrahydrobiopterin on its stability.
Topics: Animals; Arginine; Biopterins; Catalysis; Enzyme Stability; Ferrous Compounds; Heme; Models, Chemical; Neurons; Nitric Oxide Synthase; Oxygen; Rats; Spectrophotometry, Atomic | 1997 |
Regulation of cerebellar nitric oxide production in response to prolonged in vivo hypoxia.
Topics: Animals; Arginine; Argininosuccinate Lyase; Biopterins; Cerebellum; Citrulline; Endothelium, Vascular; Enzyme Induction; GTP Cyclohydrolase; Hypoxia, Brain; Isoenzymes; Male; Nerve Tissue Proteins; Neurons; Nitric Oxide; Nitric Oxide Synthase; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1997 |
Endothelial nitric oxide synthase: modulations of the distal heme site produced by progressive N-terminal deletions.
Topics: Amino Acid Sequence; Animals; Arginine; Biopterins; Catalysis; Cattle; Chromatography, Gel; Cloning, Molecular; Dimerization; Electrophoresis, Polyacrylamide Gel; Endothelium; Molecular Sequence Data; Nitric Oxide Synthase; Protein Binding; Recombinant Proteins; Sequence Alignment; Sequence Deletion; Spectrophotometry; Spectrum Analysis, Raman | 1997 |
Tetrahydrobiopterin regulates cyclic GMP-dependent electrogenic Cl- secretion in mouse ileum in vitro.
Topics: Animals; Antioxidants; Arginine; Biopterins; Carbachol; Chloride Channels; Cholinergic Agonists; Cyclic GMP; Ileum; In Vitro Techniques; Intestinal Mucosa; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Muscle, Smooth; Nitric Oxide; Nitrites; Time Factors | 1997 |
The structure of nitric oxide synthase oxygenase domain and inhibitor complexes.
Topics: Amino Acid Sequence; Arginine; Binding Sites; Biopterins; Caenorhabditis elegans Proteins; Catalysis; Crystallography, X-Ray; Dimerization; Enzyme Induction; Enzyme Inhibitors; Guanidines; Heme; Homeodomain Proteins; Hydrogen Bonding; Imidazoles; Isoenzymes; Models, Molecular; Molecular Sequence Data; Nitric Oxide Synthase; Oxidation-Reduction; Oxygen; Oxygenases; Protein Conformation; Protein Folding; Protein Structure, Secondary | 1997 |
Electron transfer and catalytic activity of nitric oxide synthases. Chimeric constructs of the neuronal, inducible, and endothelial isoforms.
Topics: Animals; Arginine; Biopterins; Calmodulin; Cattle; Cytochrome c Group; Dimerization; Egtazic Acid; Electron Transport; Isoenzymes; NADP; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Recombinant Fusion Proteins; Recombinant Proteins; Sequence Homology, Amino Acid | 1998 |
Structure of nitric oxide synthase oxygenase dimer with pterin and substrate.
Topics: Animals; Arginine; Binding Sites; Biopterins; Citrulline; Crystallography, X-Ray; Dimerization; Hydrogen Bonding; Isoenzymes; Ligands; Macrophages; Mice; Models, Molecular; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Protein Conformation; Protein Folding; Protein Structure, Secondary; Thiourea | 1998 |
Effects of pH on the structure and function of neuronal nitric oxide synthase.
Topics: Animals; Arginine; Biopterins; Brain; Citrulline; Dimerization; Heme; Hydrogen Peroxide; Hydrogen-Ion Concentration; NADP; Nerve Tissue Proteins; Nitric Oxide Synthase; Protein Binding; Protein Conformation; Rats; Spectrophotometry | 1998 |
Nitroarginine and tetrahydrobiopterin binding to the haem domain of neuronal nitric oxide synthase using a scintillation proximity assay.
Topics: Animals; Arginine; Binding Sites; Binding, Competitive; Biopterins; Enzyme Inhibitors; Heme; Indazoles; Isothiuronium; Kinetics; Nitric Oxide Synthase; Nitroarginine; Oxidoreductases; Oxygenases; Peptide Fragments; Protein Binding; Rats; Recombinant Fusion Proteins | 1998 |
Reduction by tetrahydrobiopterin of H2O2-induced endothelial cell injury.
Topics: Animals; Arginine; Biopterins; Cattle; Cells, Cultured; Endothelium, Vascular; Hydrogen Peroxide; Ionomycin; omega-N-Methylarginine; Pteridines; Pterins; Rats; Serotonin | 1998 |
The regulation of dopamine release from striatum slices by tetrahydrobiopterin and L-arginine-derived nitric oxide.
Topics: Animals; Antioxidants; Arginine; Biopterins; Catalase; Corpus Striatum; Diuretics; Dopamine; Ethacrynic Acid; Male; Nitric Oxide; Nitric Oxide Synthase; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Sugar Acids; Superoxide Dismutase; Superoxides; Tritium; Tyrosine 3-Monooxygenase | 1998 |
CO binding studies of nitric oxide synthase: effects of the substrate, inhibitors and tetrahydrobiopterin.
Topics: Animals; Arginine; Biopterins; Carbon Monoxide; Enzyme Inhibitors; Kinetics; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Photolysis; Rats; Spectrophotometry | 1998 |
Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors.
Topics: Animals; Arginine; Biopterins; Calcium; Calmodulin; Cattle; Electron Spin Resonance Spectroscopy; NADP; NADPH Oxidases; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Spin Labels; Superoxides | 1998 |
Chiral recognition at the heme active site of nitric oxide synthase is markedly enhanced by L-arginine and 5,6,7,8-tetrahydrobiopterin.
Topics: Anaerobiosis; Animals; Antioxidants; Arginine; Binding Sites; Biopterins; Calmodulin; Cloning, Molecular; Heme; Kinetics; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Recombinant Proteins; Saccharomyces cerevisiae; Spectrophotometry; Stereoisomerism | 1998 |
Superoxide generation from endothelial nitric-oxide synthase. A Ca2+/calmodulin-dependent and tetrahydrobiopterin regulatory process.
Topics: Arginine; Biopterins; Calcium; Calmodulin; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Free Radicals; Humans; NADP; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Recombinant Proteins; Sodium Cyanide; Spin Labels; Stereoisomerism; Superoxides | 1998 |
Reactions catalyzed by tetrahydrobiopterin-free nitric oxide synthase.
Topics: Amino Acids; Animals; Arginine; Biopterins; Carbon Monoxide; Catalase; Catalysis; Chromatography, Gel; Enzyme Induction; Escherichia coli; Macrophages; Mice; NADP; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Recombinant Proteins; Spectrophotometry, Ultraviolet | 1998 |
The C331A mutant of neuronal nitric-oxide synthase is defective in arginine binding.
Topics: Animals; Arginine; Biopterins; Calmodulin; Carbon Monoxide; Catalytic Domain; Conserved Sequence; Cysteine; Electron Spin Resonance Spectroscopy; Escherichia coli; Heme; Mutation; NADP; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidation-Reduction; Rats; Recombinant Proteins; Spectrophotometry; Structure-Activity Relationship | 1998 |
Sensitivity of flavin fluorescence dynamics in neuronal nitric oxide synthase to cofactor-induced conformational changes and dimerization.
Topics: Animals; Arginine; Biopterins; Brain; Calmodulin; Dimerization; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Flavins; Fluorescence Polarization; Heme; Holoenzymes; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Protein Binding; Protein Conformation; Rats; Spectrometry, Fluorescence; Substrate Specificity; Thermodynamics | 1998 |
Autoxidation rates of neuronal nitric oxide synthase: effects of the substrates, inhibitors, and modulators.
Topics: Animals; Arginine; Biopterins; Flow Injection Analysis; Kinetics; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Onium Compounds; Oxidation-Reduction; Rats; Spectrophotometry | 1998 |
Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation.
Topics: Amino Acid Sequence; Animals; Arginine; Binding Sites; Biopterins; Conserved Sequence; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Heme; Humans; Mice; Molecular Sequence Data; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Protein Structure, Secondary; Recombinant Proteins; Sequence Homology, Amino Acid; Substrate Specificity | 1999 |
Stoichiometric arginine binding in the oxygenase domain of inducible nitric oxide synthase requires a single molecule of tetrahydrobiopterin per dimer.
Topics: Animals; Arginine; Binding Sites; Biopterins; Carbon Monoxide; Chromatography, Gel; Conserved Sequence; Dimerization; Dithionite; Ferrous Compounds; Heme; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxygenases; Protein Binding; Recombinant Proteins; Spectrophotometry, Ultraviolet; Titrimetry | 1999 |
Hypoxia inhibits increased ETB receptor-mediated NO synthesis in hypertensive rat lungs.
Topics: Animals; Arginine; Biopterins; Egtazic Acid; Enzyme Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; In Vitro Techniques; Luminescent Measurements; Lung; Lysine; Male; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; Receptor, Endothelin B; Receptors, Endothelin; Time Factors | 1999 |
Cytokine-induced venodilatation in humans in vivo: eNOS masquerading as iNOS.
Topics: Adult; Arginine; Biopterins; Bradykinin; Endothelium, Vascular; Enzyme Inhibitors; Female; Gene Expression; Guanidines; Humans; Interleukin-1; Interleukin-6; Intracellular Signaling Peptides and Proteins; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Norepinephrine; omega-N-Methylarginine; Proteins; Reverse Transcriptase Polymerase Chain Reaction; Shock, Septic; Tumor Necrosis Factor-alpha; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 1999 |
Geminate recombination of nitric oxide to endothelial nitric-oxide synthase and mechanistic implications.
Topics: Arginine; Biopterins; Heme; Humans; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Photolysis; Recombinant Proteins; Spectrum Analysis | 1999 |
Tetrahydrobiopterin inhibits monomerization and is consumed during catalysis in neuronal NO synthase.
Topics: Arginine; Biopterins; Dimerization; Enzyme Stability; Escherichia coli; Humans; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Protein Conformation; Pteridines; Recombinant Proteins; Spectrophotometry; Spermine | 1999 |
Tetrahydrobiopterin-dependent inhibition of superoxide generation from neuronal nitric oxide synthase.
Topics: Animals; Arginine; Biopterins; Cattle; Citrulline; Electron Spin Resonance Spectroscopy; Models, Chemical; NADP; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxygen; Superoxides | 1999 |
Reactivity of tetrahydrobiopterin bound to nitric-oxide synthase.
Topics: Animals; Arginine; Biopterins; Cell Line; Humans; Nitric Oxide Synthase; Rats | 1999 |
Presence of excess tetrahydrobiopterin during nitric oxide production from inducible nitric oxide synthase in LPS-treated rat aorta.
Topics: Animals; Aorta, Thoracic; Arginine; Biopterins; Endothelium, Vascular; Glyceraldehyde-3-Phosphate Dehydrogenases; GTP Cyclohydrolase; Guanidines; Hypoxanthines; In Vitro Techniques; Lipopolysaccharides; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroarginine; Rats; RNA, Messenger | 1999 |
Formation of a pterin radical in the reaction of the heme domain of inducible nitric oxide synthase with oxygen.
Topics: Arginine; Biopterins; Electron Spin Resonance Spectroscopy; Free Radicals; Heme; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Oxygen; Pterins | 1999 |
Allosteric regulation of neuronal nitric oxide synthase by tetrahydrobiopterin and suppression of auto-damaging superoxide.
Topics: Allosteric Regulation; Arginine; Binding Sites; Biopterins; Catalysis; Cell Line; Enzyme Activation; Enzyme Inhibitors; Humans; Indicators and Reagents; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Protein Structure, Quaternary; Superoxides | 2000 |
Ascorbic acid enhances endothelial nitric-oxide synthase activity by increasing intracellular tetrahydrobiopterin.
Topics: Animals; Aorta; Arginine; Ascorbic Acid; Atrial Natriuretic Factor; Biopterins; Calcimycin; Cattle; Cell Line; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroprusside; Pteridines; Pterins; Recombinant Proteins; Spodoptera; Swine; Transfection | 2000 |
Structures of the N(omega)-hydroxy-L-arginine complex of inducible nitric oxide synthase oxygenase dimer with active and inactive pterins.
Topics: Animals; Arginine; Binding Sites; Biopterins; Catalysis; Crystallography, X-Ray; Dimerization; Heme; Hydrogen Bonding; Iron; Mice; Models, Chemical; Models, Molecular; Molecular Sequence Data; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Oxygen; Oxygenases; Protein Conformation; Structure-Activity Relationship | 2000 |
Aromatic residues and neighboring Arg414 in the (6R)-5,6,7, 8-tetrahydro-L-biopterin binding site of full-length neuronal nitric-oxide synthase are crucial in catalysis and heme reduction with NADPH.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Arginine; Binding Sites; Biopterins; Catalysis; Dimerization; Drosophila; Glutamine; Heme; Humans; Hydrogen Bonding; Leucine; Mice; Models, Molecular; Molecular Sequence Data; NADP; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidation-Reduction; Phenylalanine; Rats; Spectrophotometry, Atomic; Structure-Activity Relationship; Tryptophan | 2000 |
Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydrobiopterin deficiency.
Topics: Animals; Arginine; Biopterins; Calcium; Calmodulin; Chromatography, High Pressure Liquid; Diabetes Mellitus; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; GTP Cyclohydrolase; Immunoblotting; Kinetics; NADP; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Protein Isoforms; Pteridines; Pterins; Rats; Rats, Mutant Strains | 2000 |
Characterization of interactions among the heme center, tetrahydrobiopterin, and L-arginine binding sites of ferric eNOS using imidazole, cyanide, and nitric oxide as probes.
Topics: Animals; Arginine; Binding, Competitive; Biopterins; Catalysis; Cattle; Computer Simulation; Cyanides; Escherichia coli; Ferric Compounds; Flavins; Genetic Vectors; Heme; Humans; Imidazoles; Ligands; Models, Chemical; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Protein Binding | 2000 |
Inhibition of extracellular signal-regulated kinase suppresses endotoxin-induced nitric oxide synthesis in mouse macrophages and in human colon epithelial cells.
Topics: Animals; Arginine; Biological Transport; Biopterins; Cells, Cultured; Colon; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Humans; Lipopolysaccharides; Macrophages; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II | 2000 |
Arginine conversion to nitroxide by tetrahydrobiopterin-free neuronal nitric-oxide synthase. Implications for mechanism.
Topics: Arginine; Biopterins; Catalysis; Citrulline; Heme; Hydrogen Peroxide; NADP; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidation-Reduction | 2000 |
FT-Infrared spectroscopic studies of the iron ligand CO stretch mode of iNOS oxygenase domain: effect of arginine and tetrahydrobiopterin.
Topics: Animals; Arginine; Biopterins; Carbon Monoxide; Hemeproteins; Mice; Models, Chemical; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Protein Conformation; Recombinant Proteins; Spectroscopy, Fourier Transform Infrared | 2000 |
Low-temperature optical absorption spectra suggest a redox role for tetrahydrobiopterin in both steps of nitric oxide synthase catalysis.
Topics: Animals; Arginine; Biopterins; Brain; Catalysis; Dithionite; Ethylene Glycol; Freezing; Isoenzymes; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Oxidation-Reduction; Oxygen; Pterins; Rats; Reducing Agents; Spectrophotometry | 2000 |
Rapid kinetic studies link tetrahydrobiopterin radical formation to heme-dioxy reduction and arginine hydroxylation in inducible nitric-oxide synthase.
Topics: Animals; Arginine; Biopterins; Catalysis; Enzyme Activation; Free Radicals; Heme; Hydroxylation; Kinetics; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidants; Oxidation-Reduction; Oxygen; Oxygenases; Protein Structure, Tertiary; Recombinant Proteins; Reducing Agents; Spectrophotometry | 2001 |
Modulation of nitric-oxide synthase by nicotine.
Topics: Animals; Aorta, Thoracic; Arginine; Biopterins; Citrulline; Dogs; Endothelium, Vascular; Flavin-Adenine Dinucleotide; Male; NADP; Nicotine; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Recombinant Proteins | 2000 |
Kinetics of CO and NO ligation with the Cys(331)-->Ala mutant of neuronal nitric-oxide synthase.
Topics: Animals; Arginine; Biopterins; Carbon Monoxide; Cysteine; Kinetics; Neurons; Nitric Oxide; Nitric Oxide Synthase; Point Mutation; Rats | 2001 |
Endothelial dysfunction in atherosclerotic mice: improved relaxation by combined supplementation with L-arginine-tetrahydrobiopterin and enhanced vasoconstriction by endothelin.
Topics: Acetylcholine; Animals; Arginine; Arteriosclerosis; Biopterins; Dietary Supplements; Dose-Response Relationship, Drug; Endothelins; Endothelium, Vascular; Mice; Mice, Inbred C57BL; Nitroprusside; Superoxide Dismutase; Vasoconstriction; Vasodilation | 2000 |
2-thiouracil is a selective inhibitor of neuronal nitric oxide synthase antagonising tetrahydrobiopterin-dependent enzyme activation and dimerisation.
Topics: Animals; Antithyroid Agents; Arginine; Binding, Competitive; Biopterins; Cerebellum; Citrulline; Cytochrome c Group; Dimerization; Enzyme Activation; Enzyme Inhibitors; Hydrogen Peroxide; Kinetics; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Thiouracil | 2000 |
Paracrine neuroprotective effect of nitric oxide in the developing retina.
Topics: Animals; Animals, Newborn; Anisomycin; Arginine; Biopterins; Cell Death; Cells, Cultured; Cyclic GMP; Guanylate Cyclase; In Vitro Techniques; NADPH Dehydrogenase; Neuroprotective Agents; Nitric Oxide; Paracrine Communication; Penicillamine; Pteridines; Pterins; Rats; Rats, Inbred Strains; Retina; Retinal Ganglion Cells; S-Nitroso-N-Acetylpenicillamine | 2001 |
The optical interconversion of the P-450 and P-420 forms of neuronal nitric oxide synthase: effects of sodium cholate, mercury chloride and urea.
Topics: Animals; Arginine; Biopterins; Cysteine; Cytochrome P-450 Enzyme System; Cytochromes; Escherichia coli; Glycerol; Isoenzymes; Mercuric Chloride; Mice; Nitric Oxide Synthase; Plasmids; Sodium Cholate; Spectrophotometry; Transfection; Urea | 2001 |
Oxidations of N(omega)-hydroxyarginine analogues and various N-hydroxyguanidines by NO synthase II: key role of tetrahydrobiopterin in the reaction mechanism and substrate selectivity.
Topics: Antioxidants; Arginine; Biopterins; Guanidines; Hydroxylamines; NADP; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Oxidation-Reduction; Substrate Specificity; Superoxide Dismutase | 2001 |
Hypochlorite-modified low density lipoprotein inhibits nitric oxide synthesis in endothelial cells via an intracellular dislocalization of endothelial nitric-oxide synthase.
Topics: Antioxidants; Arginine; Biopterins; Blotting, Western; Cell Membrane; Cells, Cultured; Centrifugation, Density Gradient; Citrulline; Cyclic GMP; Cyclodextrins; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Golgi Apparatus; Humans; Hypochlorous Acid; Immunoblotting; Immunohistochemistry; Ionomycin; Ionophores; Lipoproteins, LDL; Microscopy, Fluorescence; Myristic Acids; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Palmitic Acids; Precipitin Tests; RNA, Messenger; Subcellular Fractions; Sucrose; Time Factors; Umbilical Veins | 2001 |
Important role of tetrahydrobiopterin in no complex formation and interdomain electron transfer in neuronal nitric-oxide synthase.
Topics: Anaerobiosis; Animals; Antioxidants; Arginine; Biopterins; Calcium; Calmodulin; Catalysis; Iron; Macromolecular Substances; Models, Chemical; Mutagenesis, Site-Directed; NADP; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidation-Reduction; Rats; Spectrophotometry | 2001 |
Tetrahydrobiopterin augments arginine transport in rat cardiac myocytes through modulation of CAT-2 mRNA.
Topics: Amino Acid Transport Systems, Basic; Animals; Antioxidants; Arginine; Biological Transport; Biopterins; Carrier Proteins; Cells, Cultured; Dose-Response Relationship, Drug; Extracellular Space; Gene Expression Regulation; Lipopolysaccharides; Membrane Proteins; Myocardium; Nitrites; Protein Isoforms; Rats; Rats, Wistar; RNA, Messenger | 2001 |
Inhibition of neuronal nitric oxide synthase by 6-nitrocatecholamines, putative reaction products of nitric oxide with catecholamines under oxidative stress conditions.
Topics: Animals; Arginine; Biopterins; Dopamine; Hydrogen Peroxide; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Norepinephrine; Oxidative Stress; Recombinant Proteins | 2001 |
Tetrahydrobiopterin: a critical cofactor for eNOS and a strategy in the treatment of endothelial dysfunction?
Topics: Animals; Arginine; Biopterins; Cardiovascular Diseases; Clinical Trials as Topic; Coronary Vessels; Dogs; Endothelium, Vascular; Enzyme Inhibitors; Histamine; Humans; Hypercholesterolemia; In Vitro Techniques; Infusions, Intra-Arterial; Ionophores; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Pteridines; Pterins; Reactive Oxygen Species; Species Specificity; Substance P; Swine; Vasoconstrictor Agents; Vasodilator Agents | 2001 |
Tetrahydrobiopterin reverses the inhibition of nitric oxide by high glucose in cultured murine mesangial cells.
Topics: Animals; Arginine; Ascorbic Acid; Biopterins; Cell Division; Cells, Cultured; Diabetic Nephropathies; Enzyme Induction; Glomerular Mesangium; Glucose; Mice; Models, Chemical; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II | 2001 |
Hypoxia impairs endothelium-dependent relaxation in organ cultured pulmonary artery.
Topics: Animals; Arginine; Biopterins; Caveolin 1; Caveolins; Cyclic GMP; Dinoprost; Dose-Response Relationship, Drug; Endothelium, Vascular; Hypoxia; Ionomycin; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroprusside; Organ Culture Techniques; Pulmonary Artery; Rabbits; RNA, Messenger; Substance P; Superoxide Dismutase; Vasoconstriction; Vasodilation; Vasodilator Agents | 2001 |
X-ray absorption spectroscopic analysis of the high-spin ferriheme site in substrate-bound neuronal nitric-oxide synthase.
Topics: Animals; Arginine; Biopterins; Catalytic Domain; Cations, Divalent; Copper; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Heme; Humans; Ligands; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Spectrum Analysis; X-Rays | 2001 |
A conserved tryptophan in nitric oxide synthase regulates heme-dioxy reduction by tetrahydrobiopterin.
Topics: Animals; Arginine; Biopterins; Conserved Sequence; Electron Spin Resonance Spectroscopy; Electrons; Heme; Kinetics; Light; Mice; Models, Chemical; Mutation; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxygen; Protein Binding; Spectrophotometry; Time Factors; Tryptophan | 2001 |
Carboxy-PTIO increases the tetrahydrobiopterin level in mouse brain microvascular endothelial cells.
Topics: Alcohol Oxidoreductases; Animals; Arginine; Benzoates; Biopterins; Brain; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; GTP Cyclohydrolase; Imidazoles; Lipopolysaccharides; Mice; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pterins; RNA, Messenger | 2001 |
Nitric oxide (NO) traffic in endothelial NO synthase. Evidence for a new NO binding site dependent on tetrahydrobiopterin?
Topics: Arginine; Binding Sites; Biopterins; Dose-Response Relationship, Drug; Heme; Humans; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Protein Binding; Recombinant Proteins; Spectrophotometry; Time Factors | 2002 |
Mechanisms of synergistic cytokine-induced nitric oxide production in human alveolar epithelial cells.
Topics: Arginine; Biopterins; Cell Line, Transformed; Cell Nucleus; Cytokines; Epithelial Cells; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Humans; NF-kappa B; Nitric Oxide; Protein Transport; Pulmonary Alveoli | 2001 |
Nitrocatechols versus nitrocatecholamines as novel competitive inhibitors of neuronal nitric oxide synthase: lack of the aminoethyl side chain determines loss of tetrahydrobiopterin-antagonizing properties.
Topics: Antioxidants; Arginine; Binding Sites; Biopterins; Catecholamines; Catechols; Drug Evaluation, Preclinical; Humans; Inhibitory Concentration 50; Kinetics; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitro Compounds; Protein Isoforms; Structure-Activity Relationship | 2002 |
Impaired endothelial regulation of ventricular relaxation in cardiac hypertrophy: role of reactive oxygen species and NADPH oxidase.
Topics: Animals; Antioxidants; Arginine; Ascorbic Acid; Biopterins; Deferoxamine; Drug Synergism; Endothelium, Vascular; Free Radical Scavengers; Glutathione; Guinea Pigs; Heart Ventricles; Hypertrophy, Left Ventricular; In Vitro Techniques; Male; Malondialdehyde; Metalloporphyrins; Myocardial Contraction; NADPH Oxidases; Oxidation-Reduction; Reactive Oxygen Species; Substance P | 2001 |
Citrulline is not the major product using the standard "NOS activity" assay on renal cortical homogenates.
Topics: Animals; Antioxidants; Arginine; Biopterins; Calcium; Carbon Radioisotopes; Chelating Agents; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Citrulline; Egtazic Acid; Enzyme Inhibitors; Female; Guanidines; Humans; Kidney Cortex; Male; Mice; Mice, Inbred Strains; NADP; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; omega-N-Methylarginine; Placenta; Rats; Rats, Long-Evans; Tritium | 2002 |
Cloning, expression, and characterization of a nitric oxide synthase protein from Deinococcus radiodurans.
Topics: Amino Acid Sequence; Animals; Arginine; Biopterins; Catalysis; Citrulline; Cloning, Molecular; Dimerization; Dithiothreitol; Dose-Response Relationship, Drug; Electrons; Heme; Hydrogen Peroxide; Kinetics; Ligands; Models, Chemical; Models, Molecular; Molecular Sequence Data; NADP; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Thermus; Time Factors; Zinc | 2002 |
Direct evidence for nitric oxide production by a nitric-oxide synthase-like protein from Bacillus subtilis.
Topics: Amino Acid Sequence; Animals; Arginine; Bacillus subtilis; Bacterial Proteins; Biopterins; Catalysis; Dimerization; Kinetics; Mammals; Molecular Sequence Data; Nitric Oxide; Nitric Oxide Synthase; Protein Structure, Secondary; Sequence Alignment; Sequence Homology, Amino Acid | 2002 |
Reactions catalyzed by the heme domain of inducible nitric oxide synthase: evidence for the involvement of tetrahydrobiopterin in electron transfer.
Topics: Arginine; Base Sequence; Biopterins; Catalysis; Chromatography, Gel; DNA Primers; Electron Transport; Heme; Molecular Weight; Nitric Oxide Synthase; Nitric Oxide Synthase Type II | 2002 |
The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study.
Topics: Arginine; Biopterins; Electron Spin Resonance Spectroscopy; Endothelium, Vascular; Kinetics; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidation-Reduction; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; Superoxides | 2002 |
Stimulation of tetrahydrobiopterin synthesis by cyclosporin A in mouse brain microvascular endothelial cells.
Topics: Animals; Antioxidants; Arginine; Biopterins; Cerebrovascular Circulation; Cycloheximide; Cyclosporine; Endothelium, Vascular; GTP Cyclohydrolase; Immunosuppressive Agents; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Protein Synthesis Inhibitors | 2002 |
Evaluation of basic performance and applicability of a newly developed in vivo nitric oxide sensor.
Topics: Acetylcholine; Animals; Antioxidants; Arginine; Biopterins; Calibration; Electrodes; Enzyme Inhibitors; Equipment Design; Nitric Oxide; Nitric Oxide Synthase; Nitroglycerin; omega-N-Methylarginine; Oxygen; Permeability; Rats; Rats, Inbred WKY; Vasodilator Agents | 2002 |
Binding of L-arginine and imidazole suggests heterogeneity of rat brain neuronal nitric oxide synthase.
Topics: Animals; Arginine; Binding, Competitive; Biopterins; Cell Line; Heme; Humans; Imidazoles; Kinetics; Mice; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Spectrophotometry, Ultraviolet; Spodoptera; Titrimetry; Tumor Cells, Cultured | 2002 |
Why do nitric oxide synthases use tetrahydrobiopterin?
Topics: Amino Acid Sequence; Amino Acid Substitution; Arginine; Biopterins; Kinetics; Models, Molecular; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Protein Conformation; Recombinant Proteins | 2002 |
The antithyroid agent 6-n-propyl-2-thiouracil is a mechanism-based inactivator of the neuronal nitric oxide synthase isoform.
Topics: Animals; Antithyroid Agents; Arginine; Biopterins; Calcium; Calmodulin; Carbon Monoxide; Carbon Radioisotopes; Citrulline; Enzyme Activation; Enzyme Inhibitors; Heme; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pituitary Neoplasms; Propylthiouracil; Rats; Thiouracil; Tumor Cells, Cultured | 2002 |
Structure of tetrahydrobiopterin tunes its electron transfer to the heme-dioxy intermediate in nitric oxide synthase.
Topics: Animals; Arginine; Biopterins; Catalysis; Crystallization; Crystallography, X-Ray; Electron Transport; Free Radicals; Heme; Isoenzymes; Kinetics; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Oxygen; Protein Binding; Pterins; Spectrophotometry, Ultraviolet; Structure-Activity Relationship | 2003 |
Induction of LOX-1 and iNOS expressions by ischemia-reperfusion of rat kidney and the opposing effect of L-arginine.
Topics: Animals; Arginine; Biopterins; Gene Expression Regulation; Kidney; Male; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Rats; Rats, Wistar; Receptors, LDL; Receptors, Oxidized LDL; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Scavenger Receptors, Class E; Superoxide Dismutase; Time Factors | 2003 |
Two modes of binding of N-hydroxyguanidines to NO synthases: first evidence for the formation of iron-N-hydroxyguanidine complexes and key role of tetrahydrobiopterin in determining the binding mode.
Topics: Arginine; Binding Sites; Biopterins; Catalysis; Electron Spin Resonance Spectroscopy; Guanidines; Heme; Hydroxylamines; Iron; Kinetics; Ligands; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidation-Reduction; Oxygen; Protein Binding; Spectrum Analysis, Raman; Structure-Activity Relationship | 2003 |
Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through the induction of GTP-cyclohydrolase I and increases nitric oxide synthase activity in vascular endothelial cells.
Topics: Animals; Arginine; Biopterins; Blotting, Northern; Brain; Cells, Cultured; Citrulline; DNA Primers; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; GTP Cyclohydrolase; Hydrogen Peroxide; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidants; Reverse Transcriptase Polymerase Chain Reaction | 2003 |
Characterization of Drosophila nitric oxide synthase: a biochemical study.
Topics: Animals; Arginine; Biopterins; Dose-Response Relationship, Drug; Drosophila; Electrons; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Heme; Hydrogen Peroxide; Hydrolysis; NADP; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Open Reading Frames; Protein Structure, Tertiary; Spectrophotometry; Time Factors; Trypsin; Ultraviolet Rays; Urea | 2003 |
Effect of tetrahydrobiopterin on blood pressure in rats after subtotal nephrectomy.
Topics: Animals; Arginine; Biopterins; Blood Pressure; Creatinine; Hypertension; Kidney; Male; Mesenteric Arteries; Nephrectomy; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Renal Insufficiency | 2003 |
A tetrahydrobiopterin radical forms and then becomes reduced during Nomega-hydroxyarginine oxidation by nitric-oxide synthase.
Topics: Animals; Arginine; Biopterins; Catalysis; Cloning, Molecular; Electron Spin Resonance Spectroscopy; Free Radicals; Freezing; Kinetics; Mice; Nitric Oxide Synthase; Oxidation-Reduction; Solutions | 2003 |
Ability of tetrahydrobiopterin analogues to support catalysis by inducible nitric oxide synthase: formation of a pterin radical is required for enzyme activity.
Topics: Amino Acids; Arginine; Binding Sites; Biopterins; Catalysis; Dithionite; Electron Spin Resonance Spectroscopy; Enzyme Activation; Free Radicals; Freezing; Heme; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Oxyhemoglobins; Protein Structure, Tertiary; Pterins; Recombinant Proteins; Time Factors | 2003 |
Three different oxygen-induced radical species in endothelial nitric-oxide synthase oxygenase domain under regulation by L-arginine and tetrahydrobiopterin.
Topics: Amino Acids; Arginine; Biopterins; Catalysis; Cytochromes c; Electron Spin Resonance Spectroscopy; Free Radicals; Heme; Humans; Kinetics; Models, Chemical; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Normal Distribution; Oxygen; Oxygenases; Protein Structure, Tertiary; Proteins; Reactive Oxygen Species; Recombinant Proteins; Spectrophotometry; Superoxides; Time Factors | 2004 |
Homocysteine induces oxidative stress by uncoupling of NO synthase activity through reduction of tetrahydrobiopterin.
Topics: Antioxidants; Arginine; Ascorbic Acid; Biopterins; Blotting, Western; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Ethidium; Fluorescent Dyes; Homocysteine; Humans; L-Lactate Dehydrogenase; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphorylation; Pterins; Reactive Nitrogen Species; Superoxides; Thrombin; Time Factors | 2004 |
Synergistic interaction between enalapril, L-arginine and tetrahydrobiopterin in smooth muscle cell apoptosis and aortic remodeling induction in SHR.
Topics: Acetylcholine; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta, Thoracic; Apoptosis; Arginine; Biopterins; Blood Pressure; Body Weight; DNA Fragmentation; Drug Synergism; Enalapril; Endothelium, Vascular; In Situ Nick-End Labeling; Male; Muscle, Smooth, Vascular; Nitric Oxide; Rats; Rats, Inbred SHR; Reactive Oxygen Species; Vasodilator Agents | 2004 |
Effect of chronic tetrahydrobiopterin supplementation on blood pressure and proteinuria in 5/6 nephrectomized rats.
Topics: Animals; Antihypertensive Agents; Antioxidants; Arginine; Biopterins; Blood Pressure; Diltiazem; Glomerular Mesangium; Hypertension; Kidney Failure, Chronic; Male; Models, Animal; Nephrectomy; Nitric Oxide; Oxidative Stress; Proteinuria; Rats; Rats, Wistar; Vasodilator Agents | 2004 |
Superoxide dismutase and catalase are required to detect (.-)NO from both coupled and uncoupled neuronal no synthase.
Topics: Arginine; Biopterins; Catalase; Electrochemistry; Electrodes; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Humans; Hydrogen Peroxide; Hydroxylation; Luminescent Measurements; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Superoxide Dismutase | 2004 |
Comparison of tetrahydrobiopterin and L-arginine on cerebral blood flow after controlled cortical impact injury in rats.
Topics: Animals; Arginine; Biopterins; Brain Injuries; Cerebral Cortex; Cerebrovascular Circulation; Nitric Oxide; Rats; Rats, Long-Evans | 2004 |
Redox function of tetrahydrobiopterin and effect of L-arginine on oxygen binding in endothelial nitric oxide synthase.
Topics: Animals; Arginine; Biopterins; Cattle; Ferric Compounds; Ferrous Compounds; Free Radicals; Heme; Humans; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidation-Reduction; Oxygen; Protein Binding; Protein Structure, Tertiary; Recombinant Proteins; Spodoptera; Two-Hybrid System Techniques | 2004 |
Endogenous methylarginines modulate superoxide as well as nitric oxide generation from neuronal nitric-oxide synthase: differences in the effects of monomethyl- and dimethylarginines in the presence and absence of tetrahydrobiopterin.
Topics: Animals; Arginine; Biopterins; Calcium; Calmodulin; Cell Line; Citrulline; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Humans; Magnetics; Nitric Oxide Synthase; omega-N-Methylarginine; Oxygen; Rats; Spin Trapping; Superoxides; Time Factors; Transfection | 2005 |
The three nitric-oxide synthases differ in their kinetics of tetrahydrobiopterin radical formation, heme-dioxy reduction, and arginine hydroxylation.
Topics: Animals; Arginine; Biopterins; Free Radicals; Heme; Humans; Hydroxylation; Kinetics; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidation-Reduction; Rats | 2005 |
A tryptophan that modulates tetrahydrobiopterin-dependent electron transfer in nitric oxide synthase regulates enzyme catalysis by additional mechanisms.
Topics: Animals; Arginine; Biopterins; Catalysis; Dimerization; Electron Transport; Enzyme Stability; Ferrous Compounds; Heme; Hydroxylation; Isoenzymes; Kinetics; Mice; Mutagenesis, Site-Directed; NADP; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Oxidation-Reduction; Protein Binding; Rats; Spectrophotometry; Tryptophan | 2005 |
Reductive activation of Cr(Vi) by nitric oxide synthase.
Topics: Animals; Arginine; Biopterins; Brain; Calcium; Calmodulin; Chromates; Chromium; Cytochrome P-450 Enzyme System; Endothelial Cells; Flavins; Hydroxyl Radical; Nitric Oxide Synthase; Oxidation-Reduction; Oxygen; Superoxides; Time Factors | 2005 |
Tetrahydrobiopterin and nitric oxide synthase dimer levels are not changed following hypoxia-ischemia in the newborn rat.
Topics: Analysis of Variance; Animals; Animals, Newborn; Arginine; Biopterins; Blotting, Western; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Electrochemistry; Enzyme Inhibitors; Functional Laterality; Gene Expression Regulation; Hypoxia-Ischemia, Brain; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar; Time Factors | 2005 |
Systemic nitric oxide production rate during hemodialysis and its relationship with nitric oxide-related factors.
Topics: Arginine; Biopterins; Blood Pressure; Female; Humans; Lipoproteins, LDL; Male; Middle Aged; Nitrates; Nitric Oxide; Renal Dialysis | 2005 |
eNOS function is developmentally regulated: uncoupling of eNOS occurs postnatally.
Topics: Aging; Animals; Arginine; Biopterins; Calcimycin; Endothelium, Vascular; Enzyme Activation; Fetus; HSP90 Heat-Shock Proteins; Humans; Nitric Oxide Synthase Type III; Pulmonary Artery; Reactive Oxygen Species; Recombinant Proteins; Sheep; Stress, Mechanical; Superoxides; Vascular Endothelial Growth Factor A; Vasodilation | 2006 |
Hyperhomocystinemia impairs endothelial function and eNOS activity via PKC activation.
Topics: Animals; Antioxidants; Aorta, Thoracic; Arginine; Biopterins; Cells, Cultured; Cystathionine beta-Synthase; Endothelium, Vascular; Enzyme Activation; Female; Gene Expression Regulation, Enzymologic; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Homocysteine; Humans; Hyperhomocysteinemia; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Protein Kinase C; Pterins; Superoxide Dismutase; Vasodilation | 2005 |
Tetrahydrobiopterin, but not L-arginine, decreases NO synthase uncoupling in cells expressing high levels of endothelial NO synthase.
Topics: Antioxidants; Arginine; Biopterins; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Humans; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Reactive Oxygen Species; Vascular Endothelial Growth Factor A | 2006 |
Reactivity of the heme-dioxygen complex of the inducible nitric oxide synthase in the presence of alternative substrates.
Topics: Animals; Arginine; Biopterins; Guanidines; Heme; Kinetics; Mice; Models, Chemical; Nitric Oxide Synthase Type II; Oxygen; Substrate Specificity | 2006 |
Regulation of the monomer-dimer equilibrium in inducible nitric-oxide synthase by nitric oxide.
Topics: Amino Acid Motifs; Animals; Arginine; Biopterins; Chelating Agents; Chromatography; Cysteine; Dimerization; Disulfides; Escherichia coli; Heme; Iron; Mass Spectrometry; Mice; Models, Chemical; Models, Molecular; Molecular Conformation; Nitric Oxide; Nitric Oxide Synthase Type II; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Spectrophotometry; Spectrum Analysis, Raman; Structure-Activity Relationship; Sulfhydryl Compounds; Time Factors; Urea; Zinc | 2006 |
Regulation of inducible nitric oxide synthase in post-operative adhesions.
Topics: Animals; Arginine; Biopsy; Biopterins; Citrulline; Female; Fibroblasts; Gene Expression Regulation, Enzymologic; Humans; Nitric Oxide Synthase Type II; Oxygen; Rats; Rats, Sprague-Dawley; Tissue Adhesions | 2006 |
Reduction of myocardial infarct size by tetrahydrobiopterin: possible involvement of mitochondrial KATP channels activation through nitric oxide production.
Topics: Animals; Anti-Arrhythmia Agents; Arginine; Biopterins; Cyclic GMP; Decanoic Acids; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hydroxy Acids; Male; Malondialdehyde; Myocardial Infarction; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitrites; Potassium Channels; Rats; Rats, Sprague-Dawley | 2006 |
Inefficient spin trapping of superoxide in the presence of nitric-oxide: implications for studies on nitric-oxide synthase uncoupling.
Topics: Animals; Arginine; Biopterins; Cell Line; Electrochemistry; Electron Spin Resonance Spectroscopy; Nitric Oxide; Nitric Oxide Synthase Type III; Protein Binding; Pyrroles; Rats; Spin Trapping; Spodoptera; Superoxide Dismutase; Superoxides | 2006 |
The role of tetrahydrobiopterin in catalysis by nitric oxide synthase.
Topics: Algorithms; Arginine; Binding Sites; Biopterins; Catalysis; Electron Transport; Heme; Molecular Structure; Nitric Oxide Synthase; Protons | 2006 |
Nitric oxide and neopterin in bipolar affective disorder.
Topics: Adult; Arginine; Biopterins; Bipolar Disorder; Chi-Square Distribution; Citrulline; Female; Humans; Male; Mental Status Schedule; Middle Aged; Neopterin; Nitric Oxide | 2006 |
Oral administration of both tetrahydrobiopterin and L-arginine prevents endothelial dysfunction in rats with chronic renal failure.
Topics: Acetylcholine; Administration, Oral; Animals; Aorta; Arginine; Biopterins; Blood Pressure; Calcimycin; Drug Synergism; Drug Therapy, Combination; Endothelium, Vascular; Kidney Failure, Chronic; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Superoxides | 2007 |
Oxygen metabolism by endothelial nitric-oxide synthase.
Topics: Animals; Arginine; Biopterins; Catalysis; Humans; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Nitrosamines; Oxygen; Reactive Oxygen Species; Recombinant Proteins | 2007 |
Changes of asymmetric dimethylarginine, nitric oxide, tetrahydrobiopterin, and oxidative stress in patients with acute myocardial infarction by medical treatments.
Topics: Adult; Aged; Arginine; Biopterins; Case-Control Studies; Drug Therapy; Endothelium, Vascular; Female; Humans; Lipoproteins, LDL; Male; Middle Aged; Myocardial Infarction; Nitric Oxide; Oxidative Stress; Superoxides | 2007 |
Oxygenase domain of Drosophila melanogaster nitric oxide synthase: unique kinetic parameters enable a more efficient NO release.
Topics: Animals; Arginine; Biopterins; Buffers; Catalysis; Computer Simulation; Drosophila melanogaster; Edetic Acid; Escherichia coli; Ferrous Compounds; Heme; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Oxygenases; Protein Structure, Tertiary; Spectrophotometry, Ultraviolet; Temperature | 2007 |
Oxygen-induced radical intermediates in the nNOS oxygenase domain regulated by L-arginine, tetrahydrobiopterin, and thiol.
Topics: Animals; Arginine; Biopterins; Electron Spin Resonance Spectroscopy; Kinetics; Nitric Oxide Synthase Type I; Oxidation-Reduction; Oxygen; Protein Binding; Protein Structure, Tertiary; Rats; Reactive Oxygen Species | 2008 |
Ageing diminishes endothelium-dependent vasodilatation and tetrahydrobiopterin content in rat skeletal muscle arterioles.
Topics: Aging; Animals; Arginase; Arginine; Arterioles; Biopterins; Endothelium, Vascular; Enzyme Inhibitors; Male; Muscle, Skeletal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Pterins; Rats; Rats, Inbred F344; Vasodilation | 2008 |
Catalytic reduction of a tetrahydrobiopterin radical within nitric-oxide synthase.
Topics: Animals; Arginine; Biopterins; Catalysis; Crystallography, X-Ray; Electron Spin Resonance Spectroscopy; Flavins; Free Radicals; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Pterins; Rats | 2008 |
Regulation of eNOS-derived superoxide by endogenous methylarginines.
Topics: Arginine; Biopterins; Electron Spin Resonance Spectroscopy; Heme; Humans; NADP; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Superoxides | 2008 |
Dietary supplementation with cholesterol and docosahexaenoic acid increases the activity of the arginine-nitric oxide pathway in tissues of young pigs.
Topics: Analysis of Variance; Animals; Animals, Newborn; Arginine; Biopterins; Blotting, Western; Brain; Cholesterol, Dietary; Chromatography, High Pressure Liquid; Citrulline; Dietary Supplements; Docosahexaenoic Acids; GTP Cyclohydrolase; Liver; Muscle, Skeletal; NADP; Nitric Oxide; Nitric Oxide Synthase; Swine | 2008 |
Generalised cranial artery spasm in human rabies.
Topics: Animals; Arginine; Biopterins; Blood Flow Velocity; Cerebral Arteries; Cerebrovascular Circulation; Child; Chiroptera; Dog Diseases; Dogs; Humans; Nitric Oxide Synthase; Nitroprusside; Rabies; Treatment Outcome; Ultrasonography, Doppler, Transcranial; Vasospasm, Intracranial; Zoonoses | 2008 |
Stabilization and characterization of a heme-oxy reaction intermediate in inducible nitric-oxide synthase.
Topics: Amino Acid Substitution; Animals; Arginine; Biopterins; Catalytic Domain; Crystallography, X-Ray; Electrochemistry; Free Radicals; Heme; Kinetics; Mice; Mutation, Missense; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidation-Reduction | 2008 |
Physarum nitric oxide synthases: genomic structures and enzymology of recombinant proteins.
Topics: Animals; Arginine; Base Sequence; Biopterins; Flavin Mononucleotide; Isoenzymes; Molecular Sequence Data; Nitric Oxide Synthase; Physarum polycephalum; RNA, Messenger | 2009 |
Effect of uncoupling endothelial nitric oxide synthase on calcium homeostasis in aged porcine endothelial cells.
Topics: Animals; Arginine; Biopterins; Bradykinin; Calcium; Cells, Cultured; Cellular Senescence; Citrulline; Cyclic GMP; Endothelial Cells; Enzyme Inhibitors; Homeostasis; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Superoxides; Swine; Time Factors | 2009 |
Detrimental effect of combined exercise training and eNOS overexpression on cardiac function after myocardial infarction.
Topics: Acetylcysteine; Actin Cytoskeleton; Animals; Antioxidants; Arginine; Biopterins; Disease Models, Animal; Exercise Therapy; Female; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myocardial Contraction; Myocardial Infarction; Myocardium; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphorylation; Physical Exertion; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Superoxides; Time Factors; Up-Regulation; Ventricular Dysfunction, Left; Ventricular Pressure; Ventricular Remodeling | 2009 |
Arginase contributes to endothelial cell oxidative stress in response to plasma from women with preeclampsia.
Topics: Arginase; Arginine; Biopterins; Endothelial Cells; Female; Humans; Molsidomine; NADPH Oxidases; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxidative Stress; Peroxynitrous Acid; Pre-Eclampsia; Pregnancy | 2010 |
Alterations in the modulation of cerebrovascular tone and blood flow by nitric oxide synthases in SHRsp with stroke.
Topics: Animals; Arginine; Biopterins; Blood Pressure; Cerebral Hemorrhage; Cerebrovascular Circulation; Enzyme Inhibitors; Homeostasis; Hypertension; Male; Middle Cerebral Artery; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Inbred SHR; Stroke; Vasodilation | 2010 |
L-arginine and antioxidant diet supplementation partially restores nitric oxide-dependent regulation of phenylephrine renal vasoconstriction in diabetics rats.
Topics: Animals; Antioxidants; Arginine; Ascorbic Acid; Biopterins; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dietary Supplements; Docosahexaenoic Acids; Eicosapentaenoic Acid; Enzyme Inhibitors; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phenylephrine; Rats; Rats, Wistar; Reactive Oxygen Species; Superoxides; Vasoconstriction; Vasoconstrictor Agents; Vitamin E | 2010 |
Decreased arteriolar tetrahydrobiopterin is linked to superoxide generation from nitric oxide synthase in mice fed high salt.
Topics: Animals; Arginine; Arterioles; Biopterins; GTP Cyclohydrolase; Male; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type III; Sodium Chloride, Dietary; Superoxides; Vasodilation | 2010 |
Tetrahydrobiopterin depletion and NOS2 uncoupling contribute to heart failure-induced alterations in atrial electrophysiology.
Topics: Action Potentials; Animals; Arginine; Atrial Fibrillation; Atrial Function, Left; Biopterins; Cardiac Pacing, Artificial; Disease Models, Animal; Dogs; Female; Heart Atria; Heart Failure; Kinetics; Male; Myocardium; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Patch-Clamp Techniques; Superoxides; Up-Regulation; Ventricular Function, Left | 2011 |
Spectroscopic, catalytic and binding properties of Bacillus subtilis NO synthase-like protein: comparison with other bacterial and mammalian NO synthases.
Topics: Animals; Arginine; Bacillus subtilis; Bacteria; Bacterial Proteins; Binding Sites; Biocatalysis; Biopterins; Citrulline; Ferric Compounds; Ferrous Compounds; Heme; Hydrogen Peroxide; Imidazoles; Kinetics; Mammals; Nitric Oxide Synthase; Oxidation-Reduction; Protein Binding; Recombinant Proteins; Species Specificity; Spectrophotometry | 2012 |
Changes in eNOS phosphorylation contribute to increased arteriolar NO release during juvenile growth.
Topics: Acetylcholine; Animals; Arginine; Arterioles; Biopterins; Calcimycin; Calcium Ionophores; Endothelium, Vascular; HSP90 Heat-Shock Proteins; Male; Muscle, Skeletal; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 2012 |
Arg375 tunes tetrahydrobiopterin functions and modulates catalysis by inducible nitric oxide synthase.
Topics: Arginine; Biopterins; Catalysis; Hydrogen Bonding; Mutagenesis, Site-Directed; Nitric Oxide Synthase Type II; Protein Binding; Protein Multimerization; Protein Structure, Secondary | 2012 |
New role for L-arginine in regulation of inducible nitric-oxide-synthase-derived superoxide anion production in raw 264.7 macrophages.
Topics: Animals; Arginine; Biopterins; Cell Line; Cell Survival; Enzyme Activation; Enzyme Inhibitors; Escherichia coli; Lipopolysaccharides; Macrophages; Mice; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Respiratory Burst; Superoxides; Time Factors; Tyrosine | 2011 |
Tetrahydrobiopterin, L-arginine and vitamin C actsynergistically to decrease oxidative stress, increase nitricoxide and improve blood flow after induction of hindlimbischemia in the rat.
Topics: Administration, Oral; Animals; Antioxidants; Arginine; Ascorbic Acid; Biopterins; Calcium; Drug Synergism; Enzyme Activation; Hindlimb; Ischemia; Male; Muscle, Skeletal; Necrosis; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Sprague-Dawley; Regional Blood Flow | 2012 |
A novel cryo-reduction method to investigate the molecular mechanism of nitric oxide synthases.
Topics: Animals; Arginine; Bacterial Proteins; Biochemistry; Biopterins; Catalytic Domain; Cold Temperature; Dose-Response Relationship, Radiation; Electrons; Gamma Rays; Isoenzymes; Mice; Models, Molecular; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Oxygen; Recombinant Proteins; Spectrum Analysis, Raman | 2012 |
Role of neural NO synthase (nNOS) uncoupling in the dysfunctional nitrergic vasorelaxation of penile arteries from insulin-resistant obese Zucker rats.
Topics: Acetophenones; Animals; Arginine; Arteries; Biopterins; Calcium; Electric Stimulation; Endothelium, Vascular; Erectile Dysfunction; GTP Cyclohydrolase; Insulin Resistance; Male; Metabolic Syndrome; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; Obesity; Oxidative Stress; Penis; Rats; Rats, Zucker; Signal Transduction; Superoxides; Vasodilation | 2012 |
Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I.
Topics: Acetylcarnitine; Adaptor Proteins, Signal Transducing; Animals; Animals, Newborn; Arginine; Biopterins; Disease Models, Animal; Endothelial Cells; Female; GTP Cyclohydrolase; HSP70 Heat-Shock Proteins; Hypertension, Pulmonary; Mitochondria; Nitric Oxide; Nitric Oxide Synthase; Pregnancy; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pulmonary Artery; Pulmonary Heart Disease; Sheep; Signal Transduction; Ubiquitin-Protein Ligases; Ubiquitination | 2012 |
Beneficial effects of the active principle component of Korean cabbage kimchi via increasing nitric oxide production and suppressing inflammation in the aorta of apoE knockout mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Aortitis; Apolipoproteins E; Arginine; Atherosclerosis; Biopterins; Cell Adhesion Molecules; Diet, Atherogenic; Disease Models, Animal; Down-Regulation; Injections, Intraperitoneal; Male; Mice; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase Type III; Phenyl Ethers; Propionates; Random Allocation; Reactive Oxygen Species; Up-Regulation | 2013 |
Electron paramagnetic resonance characterization of tetrahydrobiopterin radical formation in bacterial nitric oxide synthase compared to mammalian nitric oxide synthase.
Topics: Animals; Arginine; Bacillus subtilis; Bacterial Proteins; Biopterins; Electron Spin Resonance Spectroscopy; Escherichia coli; Free Radicals; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Rats; Species Specificity | 2012 |
Mechanism of cellular oxidation stress induced by asymmetric dimethylarginine.
Topics: Arginine; Biopterins; Enzyme Inhibitors; Human Umbilical Vein Endothelial Cells; Humans; Lysine; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress | 2012 |
Tetrahydrobiopterin, L-arginine and vitamin C act synergistically to decrease oxidant stress and increase nitric oxide that increases blood flow recovery after hindlimb ischemia in the rat.
Topics: Administration, Oral; Animals; Arginine; Ascorbic Acid; Biopterins; Calcium; Drug Synergism; Hindlimb; Ischemia; Male; Models, Biological; Muscles; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Phosphorylation; Rats; Rats, Sprague-Dawley; Recovery of Function; Regional Blood Flow | 2012 |
Ascorbate in aqueous humor augments nitric oxide production by macrophages.
Topics: alpha-MSH; Amino Acid Transport Systems, Basic; Animals; Aqueous Humor; Arginase; Arginine; Ascorbic Acid; Biological Transport; Biopterins; Calcitonin Gene-Related Peptide; Eye Proteins; Female; Gene Expression Regulation; GTP Cyclohydrolase; Macrophages; Male; Mice; Mice, Knockout; Nerve Growth Factors; Nitric Oxide; Nitric Oxide Synthase Type II; Protein Multimerization; Rabbits; Serpins; Transforming Growth Factor beta2 | 2013 |
Mechanism of inducible nitric-oxide synthase dimerization inhibition by novel pyrimidine imidazoles.
Topics: Amino Acid Substitution; Animals; Arginine; Biopterins; Cell Line; Enzyme Inhibitors; Heme; Imidazoles; Mice; Mutation, Missense; Nitric Oxide Synthase Type II; Protein Multimerization; Pyrimidines | 2013 |
The intracellular environment of human macrophages that produce nitric oxide promotes growth of mycobacteria.
Topics: Arginine; Biopterins; Cell Line; Humans; Interferon-gamma; Macrophages; Mycobacterium bovis; Mycobacterium tuberculosis; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Reactive Nitrogen Species | 2013 |
Exhaled nitric oxide measurement to monitor pulmonary hypertension in a pneumonectomy-monocrotaline rat model.
Topics: Animals; Arginine; Arterial Pressure; Biomarkers; Biopterins; Exhalation; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Nitric Oxide; Pneumonectomy; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley | 2013 |
Modulation of NO and ROS production by AdiNOS transduced vascular cells through supplementation with L-Arg and BH4: implications for gene therapy of restenosis.
Topics: Adenoviridae; Animals; Aorta; Arginine; Biopterins; Carotid Arteries; Cell Proliferation; Cell Survival; Coronary Restenosis; Cross-Linking Reagents; Disease Models, Animal; Genetic Therapy; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2013 |
Myocardial protection by co-administration of L-arginine and tetrahydrobiopterin during ischemia and reperfusion.
Topics: Animals; Arginine; Biopterins; Cardiotonic Agents; Drug Therapy, Combination; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley; Sus scrofa; Swine | 2013 |
L-arginine and tetrahydrobiopterin, but not sodium nitrite partially restored erectile dysfunction in aged rats.
Topics: Aging; Animals; Arginine; Biopterins; Dose-Response Relationship, Drug; Erectile Dysfunction; Male; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Penile Erection; Penis; Rats, Wistar; Sodium Nitrite | 2014 |
Insulin reverses D-glucose-increased nitric oxide and reactive oxygen species generation in human umbilical vein endothelial cells.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetophenones; Arginine; Biopterins; Calcitonin Gene-Related Peptide; Cationic Amino Acid Transporter 1; Cyclic N-Oxides; Gene Expression Regulation; Glucose; Human Umbilical Vein Endothelial Cells; Humans; Insulin; Mitogen-Activated Protein Kinase 1; Nitric Oxide; Nitric Oxide Synthase Type III; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; Spin Labels; Tissue Culture Techniques; Transcription Factors; Umbilical Veins; Vasoconstrictor Agents | 2015 |
Serine 1179 Phosphorylation of Endothelial Nitric Oxide Synthase Increases Superoxide Generation and Alters Cofactor Regulation.
Topics: Animals; Arginine; Biopterins; Calcium; Calmodulin; Cattle; Cell Survival; Citrulline; Electron Spin Resonance Spectroscopy; Endothelium, Vascular; HEK293 Cells; Humans; Mutation; NADP; Nitric Oxide Synthase Type III; Oxygen; Phosphorylation; Reactive Oxygen Species; Recombinant Proteins; Serine; Spin Trapping; Superoxides; Vascular Endothelial Growth Factor A | 2015 |
Tetrahydrobiopterin Supplementation Improves Phenylalanine Metabolism in a Murine Model of Severe Malaria.
Topics: Animals; Aorta; Arginine; Biopterins; Brain; Disease Models, Animal; Humans; Malaria; Mice; Mice, Inbred C57BL; Nitric Oxide; Phenylalanine; Plasmodium berghei | 2016 |
Tetrahydrobiopterin redox cycling in nitric oxide synthase: evidence supports a through-heme electron delivery.
Topics: Animals; Arginine; Biocatalysis; Biopterins; Electron Spin Resonance Spectroscopy; Electron Transport; Electrons; Free Radicals; Heme; Kinetics; Models, Molecular; Molecular Structure; Mutation; Nitric Oxide Synthase Type I; Oxidation-Reduction; Protein Binding; Protein Domains; Rats | 2016 |
Theoretical studies of the second step of the nitric oxide synthase reaction: Electron tunneling prevents uncoupling.
Topics: Animals; Arginine; Biocatalysis; Biopterins; Catalytic Domain; Citrulline; Conserved Sequence; Databases, Protein; Electron Transport; Humans; Hydrogen Bonding; Models, Molecular; NADP; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidation-Reduction; Protons; Quantum Theory; Thermodynamics | 2018 |
Tetrahydrobiopterin improves hippocampal nitric oxide-linked long-term memory.
Topics: Animals; Arginine; Biopterins; Female; GTP Cyclohydrolase; Hippocampus; Humans; Male; Memory, Long-Term; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase; Rats, Wistar; Signal Transduction | 2018 |
L-Arginine and tetrahydrobiopterin supported nitric oxide production is crucial for the microbicidal activity of neutrophils.
Topics: Adult; Arginine; Biopterins; Female; Humans; Male; Middle Aged; Neutrophils; Nitric Oxide | 2019 |
Combined l-citrulline and tetrahydrobiopterin therapy improves NO signaling and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs.
Topics: Animals; Animals, Newborn; Arginine; Biopterins; Citrulline; Hypertension, Pulmonary; Hypoxia; Nitric Oxide; Nitric Oxide Synthase Type III; Pulmonary Artery; Signal Transduction; Swine; Vascular Resistance | 2020 |
Correction of arginine metabolism with sepiapterin-the precursor of nitric oxide synthase cofactor BH
Topics: Arginine; B7-H1 Antigen; Biopterins; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Humans; Macrophages; Nitric Oxide; Nitric Oxide Synthase; Polyamines; Pterins; STAT3 Transcription Factor; THP-1 Cells | 2020 |
Decreased Expression and Uncoupling of Endothelial Nitric Oxide Synthase in the Cerebral Cortex of Rats with Thioacetamide-Induced Acute Liver Failure.
Topics: Animals; Arginine; Biopterins; Cerebral Cortex; Cerebrovascular Circulation; Gene Expression Regulation; Hepatic Encephalopathy; Liver Failure, Acute; Male; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Thioacetamide | 2021 |
Cumulative effect of simvastatin, L-arginine, and tetrahydrobiopterin on cerebral blood flow and cognitive function in Alzheimer's disease.
Topics: Alzheimer Disease; Arginine; Biopterins; Cerebrovascular Circulation; Cognition; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Neuropsychological Tests; Nitric Oxide Synthase Type III; Proof of Concept Study; Simvastatin | 2022 |