arginine and metformin

arginine has been researched along with metformin in 48 studies

Research

Studies (48)

TimeframeStudies, this research(%)All Research%
pre-19902 (4.17)18.7374
1990's3 (6.25)18.2507
2000's16 (33.33)29.6817
2010's22 (45.83)24.3611
2020's5 (10.42)2.80

Authors

AuthorsStudies
Audic, N; Ermolenko, L; Franck, G; Garcia-Alvarez, MC; Martin, MT; Nhiri, N; Potier, P; Sasaki, NA; Wang, Q1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Jensen, SL; Kühl, C; Nielsen, OV; Pedersen, J1
Carpentier, J; Lefebvre, PJ; Luyckx, AS1
Cooper, GJ; Moore, CX1
Acampora, R; De Rosa, N; Giugliano, D; Giunta, R; Marfella, R; Verrazzo, G; Ziccardi, P1
Carmellini, M; Coppelli, A; Del Guerra, S; Giannarelli, R; Lorenzetti, M; Lupi, R; Marchetti, P; Mosca, F; Navalesi, R; Tellini, C1
Boggi, U; Del Guerra, S; Del Prato, S; Fierabracci, V; Lupi, R; Marchetti, P; Marselli, L; Mosca, F; Novelli, M; Patanè, G; Piro, S1
Abbasi, F; Asagami, T; Cooke, JP; Lamendola, C; McLaughlin, T; Reaven, GM; Stuelinger, M; Tsao, PS1
Brizzi, P; Maioli, M; Secchi, G; Severino, C; Solinas, A; Tonolo, G1
Berg, C; Herrmann, BL; Mann, K; Nowak, T; Renzing-Koehler, K; Saller, B; Vogel, E1
Aktas, A; Dilek, S; Erdal, EM; Ertunc, D; Tok, EC1
Desai, M; Huang, WX; Joshi, Y; Tang, Q; Vivilecchia, RV; Yang, R1
Elbein, SC; Kern, PA; Rasouli, N; Reece, EA1
Heutling, D; Kaltwasser, P; Kleinstein, J; Krzyzanowska, K; Lehnert, H; Mittermayer, F; Nickel, I; Randeva, H; Schernthaner, G; Schulz, H; Westphal, S; Wolzt, M1
Bank, AJ; Gonzalez-Campoy, JM; Kaiser, DR; Kelly, AS; Thelen, AM1
Nelson, SM; Sattar, N1
Baser, I; Dede, M; Erbil, MK; Kenar, L; Oktenli, C; Ozgurtas, T; Sanisoglu, SY; Tapan, S; Yenen, MC; Yesilova, Z1
Asbún, J; Ceballos, G; Elisa, ZN; Emma, MN; Guzman, M; Hicks, J; Meaney, A; Meaney, E; Samaniego, V; Vela, A; Zempoalteca, JC1
Barter, PJ; Brown, BE; Davies, MJ; Nobécourt, E; Rye, KA; Yadav, S; Zeng, J1
Hutchison, SK; McGrath, BP; Meyer, C; Moran, LJ; Teede, HJ; Zoungas, S1
Bunck, MC; Cornér, A; Deng, W; Diamant, M; Eliasson, B; Heine, RJ; Kendall, DM; Malloy, JL; Shaginian, RM; Smith, U; Taskinen, MR; Yki-Järvinen, H1
Butler, AE; Butler, PC; Cox, HI; Dry, S; Galasso, R; Gurlo, T; Matveyenko, AV; Moshtaghian, A1
Bodmer, CW; Ceriello, A; Chittari, MV; Rabbani, N; Thornalley, PJ; Zehnder, D1
Chen, E; Chen, L; Choi, JH; Giacomini, KM; Iwamoto, Y; Iwasaki, N; Kubo, M; Nakamura, S; Sali, A; Schlessinger, A; Segenthelar, J; Takizawa, M1
Aydin, M; Batioglu, S; Erdogan, G; Kilic, S; Yilmaz, N; Zulfikaroglu, E1
Kanazawa, I; Sugimoto, T; Yamaguchi, T; Yamamoto, M1
Anders, S; Forst, T; Michelson, G; Mitry, M; Pfützner, A; Ratter, F; Weber, MM; Wilhelm, B1
Auge, D; Endress, B; Fromm, MF; König, J; Maas, R; Mieth, M; Strobel, J1
Carbone, A; Ciccarelli, L; Derosa, G; Fogari, E; Franzetti, IG; Maffioli, P; Piccinni, MN; Querci, F1
Abdul-Ghani, M; Cakirca, M; Camli, AA; Cikrikcioglu, MA; Erkoc, R; Hursitoglu, M; Kanat, M; Karatoprak, C; Kiskac, M; Soysal, P; Zorlu, M1
Hsu, CN; Huang, LT; Kuo, HC; Tain, YL; Tsai, CM1
Bal, F; Bekpinar, S; Gurdol, F; Kusku-Kiraz, Z; Önder, S; Unlucerci, Y; Uysal, M1
Bratt, JM; Kenyon, NJ; Linderholm, AL; Schuster, GU; Zeki, AA1
Chyrchel, B; Golay, A; Kruszelnicka, O; Surdacki, A1
Bieri, O; Bonati, U; Deuster, S; Erne, B; Fischer, D; Fischmann, A; Frank, S; Gloor, M; Gueven, N; Hafner, P; Neuhaus, C; Peters, T; Pohlman, U; Rubino, D; Rutz, E; Schmid, M; Sinnreich, M1
Berriche, O; Bouzidi, H; Haddad, M; Hammami, M; Kerkeni, M; Knani, I1
Bollenbach, A; Bonati, U; Fischer, D; Hafner, P; Hanff, E; Kayacelebi, AA; Tsikas, D1
Fortuna, P; Kałuża, B; Prof, AG; Sutkowska, E; Sutkowska, K; Wiśniewski, J1
Al-Dhabi, NA; Arasu, MV; Arockiaraj, J; C, M; Chatterjee, S; Choi, KC; Karuppiah, K; Natarajan, S; Raj, V; Ramanujam, GM; Ramasamy, M1
Kooy, A; Lehert, P; Schalkwijk, CG; Stehouwer, CDA; Top, WMC1
Ahmad, S; Alenazi, F; Alharbi, MS; Ashraf, JM; Hagbani, TA; Khaja, ASS; Qamar, M; Rafi, Z; Saleem, M; Zafar, M1
Chen, M; Jia, B; Li, Y; Liu, X; Liu, Y; Ma, T1

Reviews

2 review(s) available for arginine and metformin

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Novel therapeutic strategies for adult obese asthmatics.
    Immunology and allergy clinics of North America, 2014, Volume: 34, Issue:4

    Topics: Adenylate Kinase; Adult; Airway Remodeling; Arginine; Asthma; Dietary Supplements; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation Mediators; Metformin; Molecular Targeted Therapy; Obesity

2014

Trials

19 trial(s) available for arginine and metformin

ArticleYear
Metformin improves hemodynamic and rheological responses to L-arginine in NIDDM patients.
    Diabetes care, 1996, Volume: 19, Issue:9

    Topics: Analysis of Variance; Arginine; Blood Glucose; Blood Pressure; Blood Viscosity; Diabetes Mellitus, Type 2; Epinephrine; Female; Heart Rate; Hemodynamics; Humans; Hypoglycemic Agents; Insulin; Male; Metformin; Middle Aged; Norepinephrine; Platelet Aggregation; Rheology

1996
Metformin treatment lowers asymmetric dimethylarginine concentrations in patients with type 2 diabetes.
    Metabolism: clinical and experimental, 2002, Volume: 51, Issue:7

    Topics: Arginine; Blood Glucose; Creatinine; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Sulfonylurea Compounds; Treatment Outcome

2002
Effects of a combination of recombinant human growth hormone with metformin on glucose metabolism and body composition in patients with metabolic syndrome.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2004, Volume: 36, Issue:1

    Topics: Aged; Arginine; Blood Glucose; Blood Pressure; Body Composition; Body Constitution; Body Weight; Diabetes Mellitus, Type 2; Double-Blind Method; Fibrinogen; Glucose Tolerance Test; Glycated Hemoglobin; Growth Hormone-Releasing Hormone; Human Growth Hormone; Humans; Insulin Resistance; Insulin-Like Growth Factor I; Lipids; Male; Metabolic Syndrome; Metformin; Middle Aged; Obesity; Placebos; Testosterone

2004
Effects of pioglitazone and metformin on beta-cell function in nondiabetic subjects at high risk for type 2 diabetes.
    American journal of physiology. Endocrinology and metabolism, 2007, Volume: 292, Issue:1

    Topics: Adult; Aged; Arginine; Body Composition; Diabetes Mellitus, Type 2; Female; Glucose Tolerance Test; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Male; Metformin; Middle Aged; Pioglitazone; Risk Factors; Thiazolidinediones

2007
Rosiglitazone improves endothelial function and inflammation but not asymmetric dimethylarginine or oxidative stress in patients with type 2 diabetes mellitus.
    Vascular medicine (London, England), 2007, Volume: 12, Issue:4

    Topics: Adult; Aged; Arginine; Biomarkers; Blood Glucose; Blood Pressure; Brachial Artery; C-Reactive Protein; Carotid Arteries; Diabetes Mellitus; Double-Blind Method; Drug Therapy, Combination; Elasticity; Endothelium, Vascular; Female; Glyburide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Inflammation; Insulin; Male; Metformin; Middle Aged; Oxidative Stress; Rosiglitazone; Thiazolidinediones; Treatment Outcome; Vasodilation

2007
Metformin, arterial function, intima-media thickness and nitroxidation in metabolic syndrome: the mefisto study.
    Clinical and experimental pharmacology & physiology, 2008, Volume: 35, Issue:8

    Topics: Adult; Arginine; Carotid Arteries; Female; Humans; Hypoglycemic Agents; Male; Metabolic Syndrome; Metformin; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Tunica Intima

2008
Endothelial function and insulin resistance in polycystic ovary syndrome: the effects of medical therapy.
    Fertility and sterility, 2010, Volume: 93, Issue:1

    Topics: Adult; Arginine; Biomarkers; Blood Glucose; C-Reactive Protein; Contraceptives, Oral, Combined; Contraceptives, Oral, Hormonal; Cyproterone Acetate; Drug Therapy, Combination; Endothelium, Vascular; Ethinyl Estradiol; Female; Humans; Hyperandrogenism; Hypoglycemic Agents; Inflammation Mediators; Insulin; Insulin Resistance; Lipids; Metformin; Plasminogen Activator Inhibitor 1; Polycystic Ovary Syndrome; Sex Hormone-Binding Globulin; Testosterone; Time Factors; Treatment Outcome; Vasodilation; von Willebrand Factor

2010
One-year treatment with exenatide improves beta-cell function, compared with insulin glargine, in metformin-treated type 2 diabetic patients: a randomized, controlled trial.
    Diabetes care, 2009, Volume: 32, Issue:5

    Topics: Arginine; Blood Glucose; Body Mass Index; C-Peptide; Diabetes Mellitus, Type 2; Exenatide; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Glargine; Insulin Secretion; Insulin-Secreting Cells; Insulin, Long-Acting; Kinetics; Male; Metformin; Middle Aged; Peptides; Venoms

2009
Inflammatory-metabolic parameters in obese and nonobese normoandrogenemic polycystic ovary syndrome during metformin and oral contraceptive treatment.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2011, Volume: 27, Issue:9

    Topics: Adult; Arginine; Body Mass Index; Cardiovascular Diseases; Contraceptives, Oral; Female; Homocysteine; Humans; Hypoglycemic Agents; Insulin Resistance; Metformin; Obesity; Polycystic Ovary Syndrome; Prospective Studies; Risk Factors; Young Adult

2011
Effects of metformin and pioglitazone on serum pentosidine levels in type 2 diabetes mellitus.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2011, Volume: 119, Issue:6

    Topics: Aged; Arginine; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Glycation End Products, Advanced; Humans; Hypoglycemic Agents; Lysine; Male; Metformin; Middle Aged; Pioglitazone; Thiazolidinediones; Time Factors

2011
Addition of liraglutide in patients with Type 2 diabetes well controlled on metformin monotherapy improves several markers of vascular function.
    Diabetic medicine : a journal of the British Diabetic Association, 2012, Volume: 29, Issue:9

    Topics: Adult; Aged; Arginine; Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2; Drug Therapy, Combination; E-Selectin; Endothelium, Vascular; Female; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Liraglutide; Male; Metformin; Microcirculation; Middle Aged; Plasminogen Activator Inhibitor 1; Proinsulin; Prospective Studies

2012
Variation in inflammatory markers and glycemic parameters after 12 months of exenatide plus metformin treatment compared with metformin alone: a randomized placebo-controlled trial.
    Pharmacotherapy, 2013, Volume: 33, Issue:8

    Topics: Aged; Arginine; Biomarkers; Blood Glucose; Body Mass Index; Body Weight; C-Peptide; Chimerin Proteins; Diabetes Mellitus, Type 2; Diet; Double-Blind Method; Drug Therapy, Combination; Endpoint Determination; Exenatide; Female; Glucose Clamp Technique; Humans; Hypoglycemic Agents; Inflammation; Insulin Resistance; Male; Metformin; Middle Aged; Peptides; Resistin; Risk Factors; Serpins; Venoms

2013
Restoring Insulin Secretion (RISE): design of studies of β-cell preservation in prediabetes and early type 2 diabetes across the life span.
    Diabetes care, 2014, Volume: 37, Issue:3

    Topics: Adolescent; Adult; Aged; Arginine; Blood Glucose; C-Peptide; Child; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Gastroplasty; Glucagon-Like Peptide 1; Glucose Clamp Technique; Glucose Tolerance Test; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Liraglutide; Male; Metformin; Middle Aged; Prediabetic State; Young Adult

2014
Effect of vildagliptin add-on treatment to metformin on plasma asymmetric dimethylarginine in type 2 diabetes mellitus patients.
    Drug design, development and therapy, 2014, Volume: 8

    Topics: Adamantane; Adult; Aged; Arginine; C-Reactive Protein; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug Combinations; Female; Fibrinogen; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Nitric Oxide; Nitriles; Pyrrolidines; Vildagliptin

2014
Differential associations of circulating asymmetric dimethylarginine and cell adhesion molecules with metformin use in patients with type 2 diabetes mellitus and stable coronary artery disease.
    Amino acids, 2015, Volume: 47, Issue:9

    Topics: Aged; Aged, 80 and over; Arginine; Cell Adhesion Molecules; Coronary Artery Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Humans; Male; Metformin; Middle Aged; Time Factors

2015
Improved Muscle Function in Duchenne Muscular Dystrophy through L-Arginine and Metformin: An Investigator-Initiated, Open-Label, Single-Center, Proof-Of-Concept-Study.
    PloS one, 2016, Volume: 11, Issue:1

    Topics: Arginine; Biopsy; Child; Drug Therapy, Combination; Humans; Magnetic Resonance Imaging; Metformin; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Nitric Oxide Synthase Type I; Pilot Projects

2016
Effects of single and combined metformin and L-citrulline supplementation on L-arginine-related pathways in Becker muscular dystrophy patients: possible biochemical and clinical implications.
    Amino acids, 2018, Volume: 50, Issue:10

    Topics: Adult; Amidinotransferases; Arginine; Citrulline; Creatinine; Dietary Supplements; Female; Glycine; Guanidinoacetate N-Methyltransferase; Homoarginine; Humans; Male; Metformin; Middle Aged; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Nitrates; Nitric Oxide Synthase Type I; Treatment Outcome; Young Adult

2018
Metformin has no impact on nitric oxide production in patients with pre-diabetes.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 140

    Topics: Adult; Arginine; Citrulline; Female; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Nitric Oxide; Prediabetic State

2021
Effect of metformin on arginine and dimethylarginines in patients with advanced type 2 diabetes: A post hoc analysis of a randomized trial.
    Diabetes, obesity & metabolism, 2022, Volume: 24, Issue:10

    Topics: Arginine; Biomarkers; Diabetes Mellitus, Type 2; Humans; Metformin; Nitric Oxide

2022

Other Studies

27 other study(ies) available for arginine and metformin

ArticleYear
N-Terminal 2,3-diaminopropionic acid (Dap) peptides as efficient methylglyoxal scavengers to inhibit advanced glycation endproduct (AGE) formation.
    Bioorganic & medicinal chemistry, 2009, Mar-15, Volume: 17, Issue:6

    Topics: beta-Alanine; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Glycation End Products, Advanced; Magnetic Resonance Spectroscopy; Peptides; Pyruvaldehyde

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
The effect of metformin on the arginine induced insulin- and glucagon release in pigs.
    Acta pharmacologica et toxicologica, 1979, Volume: 44, Issue:3

    Topics: Animals; Arginine; Blood Glucose; Glucagon; Insulin; Insulin Secretion; Metformin; Secretory Rate; Swine

1979
Influence of metformin on arginine-induced glucagon secretion in human diabetes.
    Diabete & metabolisme, 1975, Volume: 1

    Topics: Adult; Aged; Arginine; Blood Glucose; Body Weight; Diabetes Mellitus; Fatty Acids, Nonesterified; Female; Glucagon; Humans; Insulin; Male; Metformin; Middle Aged

1975
Co-secretion of amylin and insulin from cultured islet beta-cells: modulation by nutrient secretagogues, islet hormones and hypoglycemic agents.
    Biochemical and biophysical research communications, 1991, Aug-30, Volume: 179, Issue:1

    Topics: Amyloid; Animals; Arginine; Cell Line; Cricetinae; Glucagon; Glucose; Glyburide; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Islet Amyloid Polypeptide; Islets of Langerhans; Kinetics; Metformin; Somatostatin; Tolbutamide

1991
The biguanide compound metformin prevents desensitization of human pancreatic islets induced by high glucose.
    European journal of pharmacology, 1999, Jan-08, Volume: 364, Issue:2-3

    Topics: Adolescent; Adult; Arginine; Biguanides; Cadaver; Dose-Response Relationship, Drug; Female; Glucose; Glyburide; Humans; Hypoglycemic Agents; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Metformin; Middle Aged

1999
Lipotoxicity in human pancreatic islets and the protective effect of metformin.
    Diabetes, 2002, Volume: 51 Suppl 1

    Topics: Arginine; Fatty Acids, Nonesterified; Glucose; Glyburide; Humans; Hypoglycemic Agents; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Metformin; Oleic Acid; Palmitates

2002
Low-dose dexamethasone in the rat: a model to study insulin resistance.
    American journal of physiology. Endocrinology and metabolism, 2002, Volume: 283, Issue:2

    Topics: Animals; Arginine; Blood Pressure; Dexamethasone; Dose-Response Relationship, Drug; Drug Combinations; Glucocorticoids; Hypertension; Hypoglycemic Agents; Injections, Subcutaneous; Insulin Resistance; Isosorbide Dinitrate; Male; Metformin; Rats; Rats, Wistar

2002
The importance of IRS-1 Gly972Arg polymorphism in evaluating the response to metformin treatment in polycystic ovary syndrome.
    Human reproduction (Oxford, England), 2005, Volume: 20, Issue:5

    Topics: Adult; Androgens; Arginine; Female; Glycine; Humans; Hypoglycemic Agents; Insulin Receptor Substrate Proteins; Insulin Resistance; Metformin; Phosphoproteins; Polycystic Ovary Syndrome; Polymorphism, Genetic; Steroids

2005
Elimination of metformin-croscarmellose sodium interaction by competition.
    International journal of pharmaceutics, 2006, Mar-27, Volume: 311, Issue:1-2

    Topics: Arginine; Binding, Competitive; Carboxymethylcellulose Sodium; Cyclohexanes; Drug Combinations; Excipients; Hypoglycemic Agents; Metformin; Models, Chemical; Nateglinide; Phenylalanine; Tablets; Technology, Pharmaceutical

2006
Asymmetrical dimethylarginine, inflammatory and metabolic parameters in women with polycystic ovary syndrome before and after metformin treatment.
    The Journal of clinical endocrinology and metabolism, 2008, Volume: 93, Issue:1

    Topics: Adult; Androgens; Arginine; Blood Glucose; Body Mass Index; C-Reactive Protein; Cholesterol, LDL; Cross-Sectional Studies; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Metformin; Polycystic Ovary Syndrome; Statistics, Nonparametric; Triglycerides; Waist-Hip Ratio

2008
Polycystic ovarian syndrome, biomarkers, and metformin: research, risk, and reality.
    The Journal of clinical endocrinology and metabolism, 2008, Volume: 93, Issue:1

    Topics: Arginine; Female; Humans; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; Risk Factors

2008
Metformin and oral contraceptive treatments reduced circulating asymmetric dimethylarginine (ADMA) levels in patients with polycystic ovary syndrome (PCOS).
    Atherosclerosis, 2008, Volume: 200, Issue:2

    Topics: Adult; Androgens; Arginine; Body Mass Index; Case-Control Studies; Contraceptives, Oral; Cyproterone Acetate; Ethinyl Estradiol; Female; Gonadotropins; Humans; Insulin Resistance; Metformin; Polycystic Ovary Syndrome; Time Factors

2008
Effects of cross-link breakers, glycation inhibitors and insulin sensitisers on HDL function and the non-enzymatic glycation of apolipoprotein A-I.
    Diabetologia, 2008, Volume: 51, Issue:6

    Topics: Apolipoprotein A-I; Arginine; Cross-Linking Reagents; Glycosylation; Guanidines; Humans; Lipoproteins, HDL; Lysine; Metformin; Phosphatidylcholine-Sterol O-Acyltransferase; Pyridoxamine; Pyruvaldehyde; Thiazoles; Tryptophan

2008
Beneficial endocrine but adverse exocrine effects of sitagliptin in the human islet amyloid polypeptide transgenic rat model of type 2 diabetes: interactions with metformin.
    Diabetes, 2009, Volume: 58, Issue:7

    Topics: Amyloid; Animals; Animals, Genetically Modified; Arginine; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucose Clamp Technique; Humans; Hyperglycemia; Hyperinsulinism; Hypoglycemic Agents; Islet Amyloid Polypeptide; Islets of Langerhans; Metformin; Pyrazines; Rats; Rats, Sprague-Dawley; Sitagliptin Phosphate; Triazoles

2009
Increased glycation and oxidative damage to apolipoprotein B100 of LDL cholesterol in patients with type 2 diabetes and effect of metformin.
    Diabetes, 2010, Volume: 59, Issue:4

    Topics: Aged; Apolipoprotein B-100; Arginine; Blood Pressure; Cholesterol; Cholesterol, LDL; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Glycation End Products, Advanced; Humans; Hypoglycemic Agents; Lipoproteins; Lipoproteins, LDL; Male; Metformin; Middle Aged; Reference Values

2010
Genetic polymorphisms in organic cation transporter 1 (OCT1) in Chinese and Japanese populations exhibit altered function.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 335, Issue:1

    Topics: Aged; Arginine; Biological Transport, Active; Biotinylation; Blotting, Western; Cell Line; China; Diabetes Mellitus, Type 2; DNA; Female; Flow Cytometry; Genetic Variation; Genotype; Green Fluorescent Proteins; Humans; Hypoglycemic Agents; Japan; Kinetics; Male; Metformin; Middle Aged; Organic Cation Transporter 1; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Sequence Alignment

2010
Interaction of the cardiovascular risk marker asymmetric dimethylarginine (ADMA) with the human cationic amino acid transporter 1 (CAT1).
    Journal of molecular and cellular cardiology, 2012, Volume: 53, Issue:3

    Topics: Arginine; Biological Transport; Biomarkers; Cardiovascular Diseases; Cationic Amino Acid Transporter 1; Gene Expression; HEK293 Cells; Humans; Kinesics; Metformin; Risk

2012
Metformin reduces asymmetric dimethylarginine and prevents hypertension in spontaneously hypertensive rats.
    Translational research : the journal of laboratory and clinical medicine, 2014, Volume: 164, Issue:6

    Topics: Amidohydrolases; Animals; Arginine; Blood Pressure; Body Weight; Hypertension; Kidney; Lung; Male; Metformin; Nitric Oxide; Rats, Inbred SHR; Rats, Inbred WKY

2014
Antidiabetic drug metformin is effective on the metabolism of asymmetric dimethylarginine in experimental liver injury.
    Diabetes research and clinical practice, 2014, Volume: 106, Issue:2

    Topics: Alanine Transaminase; Amidohydrolases; Animals; Arginine; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Galactosamine; Glutathione; Hypoglycemic Agents; Lipopolysaccharides; Male; Metformin; Peroxidase; Protective Agents; Rats; Rats, Sprague-Dawley

2014
Plasma Levels of Pentosidine, Carboxymethyl-Lysine, Soluble Receptor for Advanced Glycation End Products, and Metabolic Syndrome: The Metformin Effect.
    Disease markers, 2016, Volume: 2016

    Topics: Adult; Arginine; Biomarkers; Case-Control Studies; Diabetes Mellitus, Type 2; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Humans; Hypoglycemic Agents; Lysine; Male; Metabolic Syndrome; Metformin; Middle Aged; Prognosis; Receptor for Advanced Glycation End Products

2016
Lack of Durable Improvements in β-Cell Function Following Withdrawal of Pharmacological Interventions in Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes.
    Diabetes care, 2019, Volume: 42, Issue:9

    Topics: Adult; Arginine; B-Lymphocytes; Blood Glucose; Body Weight; C-Peptide; Diabetes Mellitus, Type 2; Fasting; Female; Glucose Intolerance; Humans; Hypoglycemic Agents; Insulin Glargine; Insulin Resistance; Liraglutide; Male; Metformin; Middle Aged; Withholding Treatment

2019
Cholecalciferol and metformin protect against lipopolysaccharide-induced endothelial dysfunction and senescence by modulating sirtuin-1 and protein arginine methyltransferase-1.
    European journal of pharmacology, 2021, Dec-05, Volume: 912

    Topics: Antioxidants; Arginine; Cell Cycle Checkpoints; Cell Line; Cellular Senescence; Cholecalciferol; Endothelium; Homocysteine; Humans; Lipopolysaccharides; Metformin; Methylation; NAD; Nitric Oxide; Protective Agents; Protein-Arginine N-Methyltransferases; Repressor Proteins; S-Adenosylmethionine; Sirtuin 1; Telomerase; Vitamin D Response Element

2021
Metformin encapsulated gold nanoparticles (MTF-GNPs): A promising antiglycation agent.
    Cell biochemistry and function, 2022, Volume: 40, Issue:7

    Topics: Arginine; Diabetes Mellitus, Type 2; Glycation End Products, Advanced; Gold; Humans; Hypoglycemic Agents; Lysine; Metal Nanoparticles; Metformin; Ribose; Serum Albumin, Bovine

2022
Carbonized polymer dots derived from metformin and L-arginine for tumor cell membrane- and mitochondria-dual targeting therapy.
    Nanoscale, 2023, Nov-16, Volume: 15, Issue:44

    Topics: Apoptosis; Arginine; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Humans; Lung Neoplasms; Metformin; Mitochondria; Reactive Oxygen Species

2023