arginine has been researched along with mci 9038 in 988 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 37 (3.74) | 18.7374 |
| 1990's | 172 (17.41) | 18.2507 |
| 2000's | 423 (42.81) | 29.6817 |
| 2010's | 290 (29.35) | 24.3611 |
| 2020's | 66 (6.68) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Imanishi, Y; Ito, Y; Liu, LS; Matsuo, R | 1 |
| Collen, D; Gold, HK; Imura, Y; Lesaffre, E; Stassen, JM; Vreys, I | 1 |
| Hanashiro, K; Kinjoh, K; Kosugi, T; Nakamura, M; Saitoh, S | 1 |
| Atagi, S; Fukuta, K; Ogura, T; Sone, S | 1 |
| Tomoda, H | 1 |
| Eguchi, S; Emori, T; Hirata, Y; Imai, T; Kanno, K; Marumo, F; Ohta, K | 1 |
| Chikahira, Y; Kario, K; Matsuo, T; Nakao, K; Yamada, T | 1 |
| Bode, W; Brandstetter, H; Edwards, BF; Grosse, D; Hoeffken, HW; Martin, PD; Stürzebecher, J; Turk, D | 1 |
| Hijikata-Okunomiya, A; Okamoto, S | 2 |
| Loscalzo, J; Scharfstein, J | 1 |
| Collen, D; Imura, Y; Stassen, JM | 1 |
| Hirase, T; Kario, K; Kobayashi, H; Matsuo, T; Miki, T; Sakamoto, S; Yamada, T | 1 |
| Kario, K; Kodama, K; Matsuo, T; Okamoto, S | 1 |
| Matsuo, M; Matsuo, T; Sakai, R; Yamada, T | 1 |
| Hyon, SH; Ikada, Y; Nakamura, T; Wada, R | 1 |
| Schneider, J | 1 |
| Akiba, T; Shibamoto, T | 1 |
| Funahara, Y; Hijikata-Okunomiya, A; Opartkiattikul, N | 1 |
| De Meester, I; Hendriks, D; Scharpe, S; van Sande, M; Vanhoof, G; Vriend, G | 1 |
| Kario, K; Matsuo, M; Matsuo, T | 1 |
| Banner, DW; Hadváry, P | 2 |
| Iwamoto, M; Kumada, T; Morishita, K; Tanaka, T; Tomikawa, M; Wada, M | 1 |
| Clarke, RJ; Fitzgerald, DJ; FitzGerald, GA; Mayo, G | 1 |
| Higashiyama, M; Kambayashi, J; Mori, T; Sakon, M; Tanaka, T; Tsujinaka, T; Yokota, M | 1 |
| Collen, D; Fallon, JT; Gold, HK; Guerrero, JL; Holt, R; Jang, IK; Leinbach, RC; Yaoita, H; Yasuda, T | 1 |
| Chesebro, JH; Fuster, V | 1 |
| Collen, D; Fallon, JT; Gold, HK; Jang, IK; Leinbach, RC | 1 |
| Bush, LR; Connolly, TM; Mellott, MJ; York, SJ | 1 |
| Maruyama, I | 1 |
| Bode, W; Stürzebecher, J; Turk, D | 1 |
| Hijikata-Okunomiya, A; Okamoto, S; Wanaka, K | 2 |
| Collen, D; Fallon, JT; Gold, HK; Jang, IK; Leinbach, RC; Ziskind, AA | 1 |
| Hijikata-Okunomiya, A | 1 |
| Matsuo, T; Ryo, R; Yamada, T; Yamanashi, T | 1 |
| Fitzgerald, DJ; Fitzgerald, GA | 1 |
| Kitani, M; Kobayashi, S; Okada, K; Suzuki, T; Tsunematsu, T; Yamaguchi, S | 1 |
| Allison, P; Ashton, J; Buja, LM; Eidt, JF; Golino, P; McNatt, J; Noble, S; Willerson, JT | 2 |
| Breddin, HK; Haarmann, W; Krupinski, K; Markwardt, F | 1 |
| Matsuo, O; Matsuo, T; Nakao, K; Yamada, T | 2 |
| Hijikata-Okunomiya, A; Kikumoto, R; Matsumoto, O; Ohkubo, K; Okamoto, S; Tamao, Y; Tezuka, T; Tonomura, S | 1 |
| Matsui, N | 1 |
| Chikahira, Y; Matsuo, O; Matsuo, T; Nakao, K; Ueshima, S; Yamada, T | 1 |
| Matsuo, T; Nakao, K; Yamada, T | 1 |
| Abiko, Y; Hara, T; Iwamoto, M; Kumada, T; Ogawa, H; Tomikawa, M | 1 |
| Matsuo, T | 3 |
| Handa, H; Ishikawa, J; Kamijo, Y; Oda, Y; Okamoto, S; Satoh, M; Shimizu, Y; Tsuda, H; Yamagami, T; Yonekawa, Y | 1 |
| Hijikata-Okunomiya, A; Hirata, M; Kitaguchi, H | 1 |
| Hara, H; Kikumoto, R; Okamoto, S; Tamao, Y | 1 |
| Higuchi, M; Kakishita, E; Maeda, S; Miyamoto, T; Nagai, K; Nakajima, T; Sakurai, T; Ueda, T | 1 |
| Etoh, T; Higuchi, M; Ikezawa, K; Kakishita, E; Kanamaru, A; Kunitomi, O; Nagai, K; Nakajima, T; Nishida, Y | 1 |
| Akutsu, T; Iwata, H; Matsuda, T; Noda, H; Takano, H; Toyosaki, T | 1 |
| Horie, N; Nagamatsu, Y; Okamoto, U; Sasaki, K; Yamamoto, J | 1 |
| Cohen, I; Green, D; Kahn, D; Kohl, H; Reynolds, N; Ts'ao, C | 1 |
| Hatano, Y; Mori, K; Nakamura, K | 1 |
| Brüggener, E; Hauptmann, J; Müller, H | 1 |
| Bannai, K; Ishigaki, S; Ishii, B; Kogawa, K; Kohgo, Y; Koshida, Y; Kumai, R; Mogi, Y; Niitsu, Y; Urushizaki, I | 1 |
| Mihara, H; Satsuma, J; Yoshihara, H | 1 |
| Edazawa, H; Goda, T; Matsukura, H; Sakai, K; Takeda, H; Tanabe, T; Uzawa, S | 1 |
| Fuse, I; Hattori, A; Nagayama, R; Shibata, A; Takahashi, H | 1 |
| Fujita, T; Kumon, K; Naito, Y; Nakajima, N; Tanaka, K | 1 |
| Ito, M; Suzuki, Y; Yamada, H | 1 |
| Ego, Y; Fujita, T; Kumon, K; Naito, Y; Sugawara, H; Tanaka, K | 1 |
| Hirasawa, Y; Kawaguchi, H; Koshikawa, S; Maeda, K; Matsui, N; Nakagawa, S; Ota, K; Sasaoka, T | 1 |
| Yamada, K | 1 |
| Matsukura, H; Takeda, H; Tanabe, T; Uzawa, S | 1 |
| Czervionke, RL; Fry, GL; Haycraft, DL; Hoak, JC | 1 |
| Hara, H; Hijikata, A; Kikumoto, R; Ninomiya, K; Okamoto, S; Tamao, Y; Tezuka, T; Tonomura, S | 1 |
| Abiko, Y; Kumada, T | 1 |
| Hara, H; Hijikata, A; Kikumoto, R; Maruyama, A; Ninomiya, K; Okamoto, S; Sugano, M; Tamao, Y; Tonomura, S | 1 |
| Jain, K; Ku, DD; Winn, MJ | 1 |
| Hirata, Y; Imai, T; Marumo, F | 1 |
| Enami, T; Hoson, M; Kashimura, T; Kawada, T; Mochizuki, A; Nakada, K; Wakisaka, M; Yamate, N | 1 |
| Callas, DD; Fareed, J | 2 |
| Yamamoto, T | 1 |
| Ishihara, H; Kawai, H; Nakashima, M; Umemura, K | 1 |
| Callas, DD; Fareed, J; Hoppensteadt, D | 1 |
| Adachi, K; Koide, M; Matsuo, T; Miki, T; Mizutani, K; Ohga, N; Sakamoto, S; Suzuki, S | 1 |
| Hanaoka, T | 1 |
| Fujino, S; Fujioka, S; Hamada, H; Hiwada, K; Inoue, Y; Kohno, N; Yokoyama, A | 1 |
| Nakashima, M; Nishiyama, H; Saniabadi, AR; Takiguchi, Y; Uematsu, T; Umemura, K | 1 |
| Berry, CN; Girardot, C; Lecoffre, C; Lunven, C | 1 |
| Berry, CN; Girard, D; Lecoffre, C; Lochot, S | 1 |
| Abe, H; Endo, S; Funaki, S; Kamata, S; Kawada, T; Kikuchi, K; Mieda, T; Miyamoto, S; Nakamura, S; Nishimura, K | 1 |
| Kario, K; Matsuo, M; Matsuo, T; Yamada, T | 1 |
| Hara, H; Kawai, H; Tamao, Y; Yamamoto, T | 1 |
| Herrman, JP; Serruys, PW | 1 |
| Bovill, EG; Collen, D; Garabedian, HD; Gold, HK; Hagstrom, JN; Newell, JB | 1 |
| Allen, GT; Antonaccio, MJ; Normandin, D; Tesfamariam, B | 1 |
| Kogan, TP; Rawson, TE; VanGorp, KA; Yang, J | 1 |
| Molloy, CJ; Taylor, DS; Webb, ML | 1 |
| Claeson, G; Ehrhardt, C; Metternich, R; Scully, MF; Stone, SR; Tapparelli, C; Zurini, M | 1 |
| Garabedian, HD; Gold, HK; Hagstrom, JN; Jang, IK; Khan, A; Leinbach, RC; Newell, JB; Torres, FW; Werner, W; Yasuda, T | 1 |
| Casscells, W; Willerson, JT | 1 |
| Matsuoka, A; Sasaki, Y; Yamamoto, J; Yamashita, T | 1 |
| Kawai, H; Nakashima, M; Umemura, K | 1 |
| Kobayashi, H; Koide, M; Matsuo, M; Matsuo, T; Sakamoto, S; Shimano, C; Suzuki, S | 1 |
| Hirase, T; Matsuo, T; Miki, T; Sakamoto, S; Suzuki, S; Tsukamoto, T; Yamada, T | 1 |
| Kawai, H; Tamao, Y | 1 |
| Kario, K; Kodama, K; Koide, M; Matsuo, T | 1 |
| Fukushi, H; Imura, Y; Kawamura, M; Kita, S; Moriya, N; Nishikawa, K; Sugihara, H; Terashita, Z | 1 |
| Arita, M; Hamada, M; Hano, T; Imanishi, T; Nakai, K; Nishio, I; Ohmori, H; Shiizaki, K; Tomobuchi, Y | 1 |
| Berry, CN; Gauffeny, C; Lecoffre, C; Lunven, C; O'Brien, DP; Roome, NO | 1 |
| Nawarskas, JJ; Spinler, SA | 1 |
| Akiguchi, I; Kaji, R; Kanda, M; Murase, N; Satoi, H | 1 |
| Andrade-Gordon, P; Costanzo, MJ; Hecker, LR; Kauffman, JA; Krishnan, R; Lewis, JM; Maryanoff, BE; Schott, MR; Tulinsky, A; Yabut, SC; Zhang, HC | 1 |
| Berry, CN; Duval, N; Grosset, A; Lunven, C; O'Brien, DP; O'Connor, SE | 1 |
| Coulombe, R; Cygler, M; Féthière, J; Konishi, Y; Tsuda, Y | 1 |
| Kawai, H; Sugimoto, J; Tamao, Y; Yuki, S | 1 |
| Donkin, J; Iaffaldano, R; Lewis, BE; McKiernan, TL; Rao, L; Wallenga, JM | 1 |
| Grootenhuis, PD; Karplus, M | 1 |
| Heran, CL; Schumacher, WA; Steinbacher, TE | 1 |
| Berry, CN; Girard, D; Girardot, C; Lochot, S; Lunven, C; Visconte, C | 1 |
| Börjesson, I; Elg, M; Gustafsson, D; Lenfors, S; Teger-Nilsson, AC | 1 |
| Kinjoh, K; Kosugi, T; Masuda, Y; Nakamura, M; Sunagawa, M; Yamashita, S | 1 |
| Fitzgerald, D; Murphy, N | 1 |
| Aoki, N; Fujimori, Y; Kawai, K; Nakamura, F; Omata, M; Sakamoto, Y; Tomaru, T; Uchida, Y | 1 |
| Aoki, N; Nakamura, F; Omata, M; Sakamoto, Y; Tomaru, T; Uchida, Y | 1 |
| Mochizuki, M; Nagai, N; Nakajima, K; Nakano, T; Takada, A; Takada, Y; Urano, T | 1 |
| Kleiman, NS | 1 |
| Fuji, H; Kosogabe, Y; Kurasako, N; Mano, M; Nagase, H; Sakano, S; Takebayashi, T; Tanaka, T | 1 |
| Gustafsson, D; Lenfors, S | 1 |
| Verstraete, M | 2 |
| Aoki, N; Fujimori, Y; Morita, T; Nakamura, F; Omata, M; Sakamoto, Y; Tomaru, T; Uchida, Y | 1 |
| Ogura, K; Soda, T | 1 |
| Furukawa, F; Takigawa, M; Wakita, H | 1 |
| Grassman, ED; Lewis, BE; Rangel, Y; Wrona, L | 1 |
| Nozaki, M; Okano, T; Suzuki, K; Takemura, N; Terada, S | 1 |
| Drobot, D; Harding, SR; Lyon, AW; Lyon, ME | 1 |
| Derian, CK; Eckardt, AJ | 1 |
| Arita, M; Hamada, M; Hano, T; Imanishi, T; Nishio, I; Tomobuchi, Y | 2 |
| Jones-Hertzog, DK; Jorgensen, WL | 1 |
| Callas, D; Fareed, J; Hayes, JM; Iqbal, O; Jeske, W | 1 |
| Giddings, JC; Kawano, M; Sasaki, Y; Watanabe, S; Yamamoto, J | 1 |
| Hermann, JP; Kutryk, MJ; Serruys, PW | 1 |
| Lewis, BE; Walenga, JM; Wallis, DE | 1 |
| Kambayashi, J; Kawasaki, T; Kim, DI; Sakon, M; Shibuya, T | 1 |
| Clark, DE; Murray, CW; Westhead, DR | 1 |
| Kario, K; Koide, M; Matsuo, T | 2 |
| Fareed, J; Hoppensteadt, DA; Kahn, S | 1 |
| Imiya, M; Matsuo, T | 1 |
| Prasa, D; Stürzebecher, J; Svendsen, L | 1 |
| Deinum, J; Elg, M; Gustafsson, D | 1 |
| Hara, T; Kunitada, S; Morishima, Y; Tanabe, K; Terada, Y | 1 |
| Fareed, J; Lewis, BE; Rangel, Y | 1 |
| Berry, CN; Charles, MC; Ferrari, P; Girard, D; Girardot, C; Lechaire, I; Lunven, C; O'Brien, DP | 1 |
| Théroux, P; Xiao, Z | 1 |
| Hijikata-Okunomiya, A; Okada, Y; Okamoto, S; Okamoto, U; Wanaka, K | 1 |
| Alford, KL; Becker, JC; Brooks, RL; Hursting, MJ; Joffrion, JL; Knappenberger, GD; Kogan, PW; Kogan, TP; McKinney, AA; Schwarz, RP | 1 |
| Kikumoto, R; Tamao, Y | 1 |
| Kobayashi, S; Tazaki, Y | 1 |
| Hirayama, F; Kawasaki, T; Koshio, H; Matsumoto, Y; Sato, K; Taniuchi, Y | 2 |
| Hirayama, F; Hisamichi, N; Kawasaki, T; Koshio, H; Matsumoto, Y; Sato, K; Taniuchi, Y | 1 |
| Ikada, Y; Iwata, H; Noguchi, H | 1 |
| Hirayama, F; Kawasaki, T; Koshio, H; Matsumoto, Y; Sakai, Y; Sato, K; Taniuchi, Y | 1 |
| Deschenes, I; DiMaio, J; Finkle, CD; Leblond, L; St Pierre, A; Winocour, PD | 1 |
| Kawatani, A; Kobayashi, A; Kurosawa, Y; Miki, S; Mizoguchi, T; Murata, S; Nakajima, H; Sakurai, T; Takeuchi, T; Yoshida, A | 1 |
| Ishida, H; Nakayasu, H; Nukaya, H; Tsuji, K | 2 |
| Fujii, K; Koide, M; Matsuo, M; Matsuo, T; Sakamoto, S; Suzuki, S | 1 |
| Horie, K; Kyogashima, M; Miyauchi, S; Mizuno, S; Onaya, J; Sunose, A | 1 |
| Naylor-Olsen, AM; Sanderson, PE | 1 |
| Ishibashi, O; Ishikawa, S; Mitsui, K; Mitsui, T; Onizuka, M; Suga, M | 1 |
| Hantgan, RR; Hursting, MJ; Jerome, WG | 1 |
| Barrowcliffe, TW; Goodnight, SH; Green, D; Laposata, M; Sosolik, RC; Van Cott, EM | 1 |
| Hijikata-Okunomiya, A; Inoue, N; Ishikawa, Y; Nakaya, Y; Takahashi, A; Taniguchi, T | 1 |
| Berry, CN; Girardot, C; Lechaire, I; Lunven, C; O'Connor, SE | 1 |
| Koide, M; Matsuo, T | 1 |
| Berry, CN; Gandossi, E; Gauffeny, C; Lunven, C; Roome, NO | 1 |
| Chong, BH; Ortel, TL | 1 |
| Maruyama, I; Mohri, M; Sata, M; Sugimoto, E; Suzuki, M; Yamamoto, S | 1 |
| Iwamoto, M; Morishita, K | 1 |
| Deinum, J; Nilsson, T; Sjöling-Ericksson, A | 1 |
| Akiguchi, I; Kimura, J; Kinoshita, M; Nishimura, M; Osaki, A; Tomimoto, H; Wakita, H | 1 |
| Becker, JC; Hursting, MJ; Joffrion, JL; Knappenberger, GD; Schwarz, RP; Zehnder, JL | 1 |
| Fukazawa, T; Goto, Y; Hayashi, H; Inoue, Y; Komatsu, Y | 1 |
| Agnelli, G; Taliani, MR | 1 |
| Crowley, JJ; Kruse, KR; Millare, DS; Phillips, HR; Santos, RM; Stack, RS; Tanguay, JF; Zidar, JP | 1 |
| Abe, H; Endo, S; Hoson, M; Kawada, T; Kimura, K; Kitanaka, Y; Okada, Y; Yamate, N; Yokoyama, M | 1 |
| Hoshide, S; Kario, K; Matsuo, T; Shimada, K; Umeda, Y | 1 |
| Benincosa, LJ; Di Cicco, RA; Hursting, MJ; Jorkasky, DK; Peng, L; Sheth, SB; Tran, JQ; Tucci, M | 1 |
| Itoh, T; Naitoh, K; Narita, Y; Natsuaki, M; Ohteki, H; Sakai, M | 1 |
| Ahmad, S; Callas, D; Fareed, J; Haas, S; Hoppensteadt, DA; Jeske, WP; Lietz, H; Messmore, HL; Walenga, JM | 1 |
| Matthai, WH | 3 |
| Ahmad, S; Bakhos, M; Fasanella, AR; Hoppensteadt, DA; Iqbal, O; Walenga, JM; Wallis, DE | 1 |
| Bakhos, M; Fareed, J; Jeske, WP; Lewis, BE; Leya, F; Walenga, JM; Wallis, DE | 1 |
| Anderson, HV; Bazzino, O; Brown, DF; Dinsmore, R; Dutra, OP; Giugliano, RP; Jang, IK; Liprandi, AS; Losordo, D; Massey, TJ; Nicolau, JC; Norbady, R; Schwarz, RP; Viamonte, VM | 1 |
| Jang, IK; Januzzi, JL | 1 |
| Akiguchi, I; Tomimoto, H | 1 |
| Armstrong, PW; Choy, JB | 1 |
| Cella, G; Girolami, A; Sasahara, AA | 1 |
| Nozaki, M; Okano, T; Sasaki, K; Suzuki, K; Terada, S | 1 |
| Eguchi, K; Kizaki, Y; Matsumoto, K; Matsunaga, Y; Miyake, S; Tominaga, Y; Ueki, Y; Yano, M; Yoshida, K | 1 |
| Arnoletti, JP; Whitman, GJ | 1 |
| Ishida, H; Nakayasu, H; Tsuji, K | 1 |
| Allen, MC; Ambler, J; Brundish, D; Bull, A; Butler, K; Donovan, V; Fullerton, JD; Garman, SM; Hayler, JF; Howarth, G; Hoyle, W; Janus, D; Kane, PD; McDonnell, M; Smith, GP; Talbot, MD; Wakeford, R; Walker, CV | 1 |
| Hirasawa, Y; Ito, K; Kato, Y; Kita, Y; Motoyama, Y; Nishio, M; Seki, J; Yamanaka, T | 1 |
| Fujimura, Y; Kuwahara, M; Matsui, H; Miyata, S; Sugimoto, M; Tsuji, S; Yoshioka, A | 1 |
| Hijikata-Okunomiya, A; Inoue, N; Ishikawa, Y; Nakaya, Y; Okada, Y; Takahashi, A; Taniguchi, T; Tsuda, Y; Wanaka, K | 1 |
| Hirayama, T; Jin, YJ; Mima, T; Mori, K; Mostafa, MG | 1 |
| Ahmad, S; Ahsan, A; Fareed, J; Hoppensteadt, DA; Iqbal, O; Lewis, BE; Walenga, JM | 1 |
| Bentley, R; Bostwick, J; Brown, K; Chu, V; Colussi, D; Czekaj, M; Heran, C; Kasiewski, C; Klein, S; Leadley, R; Morgan, S; Perrone, M | 1 |
| Kubo, Y; Kudo, A; Kurose, A; Ogasawara, K; Ogawa, A; Sawai, T; Suzuki, M; Suzuki, T; Yoshida, K | 1 |
| Doi, K; Furukawa, K; Narita, Y; Ohnishi, H; Ohteki, H; Sakai, M | 1 |
| Ahmad, S; Ahsan, A; Fareed, J; George, M; Iqbal, O; Jeske, WP; Lewis, BE; McKenna, R; Walenga, JM | 1 |
| Hursting, MJ; Swan, SK | 1 |
| Maruki, Y; Matsuzaki, M; Narabayashi, Y; Onoda, A; Sawada, M; Shimazu, K | 1 |
| Fudaba, H; Hayashida, O; Nagamitsu, T; Nagatsuna, T; Wakuta, Y; Yamashita, T | 1 |
| Katayama, Y; Otsubo, K | 1 |
| Harding, SR; Lyon, AW; Lyon, ME; Oosman, SN | 1 |
| Ikada, Y; Iwata, H; Matsuda, S; Oowaki, H; Richey, T; Uchida, E | 1 |
| Ataullakhanov, FI; Krasotkina, YV; Sinauridze, EI | 1 |
| Collen, D; Kozawa, O; Matsuno, H; Matsuo, O; Uematsu, T; Ueshima, S | 1 |
| Davidian, M; Oberg, A | 1 |
| Hoson, M; Kawada, T; Kitagawa, H; Okada, Y; Shiomura, J | 1 |
| Kobayakawa, N; Morita, T; Nakamura, F; Onitake, A; Tomaru, T; Uchida, Y | 1 |
| Kobayashi, H; Koide, M; Matsuo, M; Matsuo, T; Sakamoto, S; Shimamo, C; Suzuki, S | 1 |
| Hayakawa, M; Matsuzawa, M; Morishima, H; Ono, H; Oshima, K; Taguchi, Y | 1 |
| Ahmad, S; Ahsan, A; Fareed, J; Fu, K; Hoppensteadt, DA; Iqbal, O; Lewis, BE; Walenga, JM; Yang, LH | 1 |
| Hino, M; Kumura, T; Tatsumi, N; Yamane, T | 1 |
| Hursting, MJ; Lambrecht, LJ; St Peter, JV; Swan, SK | 1 |
| Ambler, J; Baettig, U; Brown, L; Brundish, D; Cockcroft, X; Dell, C; Furzer, A; Garman, S; Janus, D; Kane, PD; Mitchelson, A; Smith, G; Talbot, MD; Tweed, M; Walker, CV; Wills, N | 1 |
| André, F; Berry, CN; Garrigou-Gadenne, D; Lainée, P; Lecoffre, C; Lunven, C; O'Connor, SE; Roger, B; Roome, NO; Rouchouse, A; Vivan, N | 1 |
| Berry, CN; Girard, D; Lecoffre, C; Lochot, S; Visconte, C | 1 |
| Jang, IK; Sabatine, MS; Tu, TM | 1 |
| Miller, JL | 1 |
| Konishi, Y; Medvedkin, V; Okada, Y; Seki, J; Slon-Usakiewicz, J; Taka, T; Tsuda, Y; Yamamoto, J | 1 |
| Fukuda, K; Hosokawa, M; Kodama, M; Nakamura, H; Ohya, M; Onomura, M; Seino, Y; Tsukada, H | 1 |
| Maeno, T; Mano, T; Takenaka, H; Tano, Y | 1 |
| Cho, J; Dan, T; Kim, H; Koga, T; Koo, B; Seo, H; Yoshida, S; Yun, C | 1 |
| Akiguchi, I; Ogura, S; Ohtani, R; Tomimoto, H; Wakita, H; Yagi, H | 1 |
| Fukao, H; Matsuo, O; Okada, K; Ueshima, S | 1 |
| Besse, P; Darius, H; Fels, PW; Fitzgerald, D; Garrigou, D; Müller, E; Puel, J; Simoons, ML; Vahanian, A; Van de Werf, F; Vermeer, F | 1 |
| Greinacher, A; Lubenow, N | 2 |
| Aisaka, K; Hayashi, M; Matsuo, A; Nakamoto, H | 1 |
| White, HD; Wong, CK | 1 |
| Kato, T; Morita, A | 1 |
| Tanaka, K | 1 |
| Bartholomew, J; Berkowitz, SD; Fareed, J; Hursting, MJ; Jang, IK; Kelton, JG; Lerner, RG; Lewis, BE; Matthai, WH; Moran, J; Rifkin, SD; Rustagi, PK; Sham, R; Walenga, JM; Wallis, DE; Zeigler, ZR | 1 |
| Kondo, LM; Wiggins, BS; Wittkowsky, AK | 1 |
| Baglin, TP | 1 |
| DiCicco, RA; Hursting, MJ; Jorkasky, DK; Montague, T; Sheth, SB | 1 |
| Hauptmann, J; Steinmetzer, T; Sturzebecher, J | 1 |
| McKeage, K; Plosker, GL | 1 |
| Fleischer, K; Gulba, DC; Lankes, W | 1 |
| Endo, H; Fujiki, T; Ide, H; Imamura, K; Sato, M; Sudo, K | 1 |
| Hosomi, N; Kohno, M; Mizushige, K; Ohyama, H; Takahashi, T | 1 |
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| Epperla, N; Jayarangaiah, A | 1 |
| Becher, T; Mayer, G; Müller, J; Pötzsch, B | 1 |
| Biron-Andréani, C; de Maistre, E; Grosjean, S; Gruel, Y; Grunebaum, L; Morange, PE; Morel, J; Nguyen, P; Tardy-Poncet, B; Thiranos, JC; Villacorta-Torres, J; Wynckel, A | 1 |
| Hayashi, Y; Taguchi, A; Takayama, K; Yakushiji, F | 1 |
| Fushimi, K; Horiguchi, H; Matsubara, T; Nakajima, S; Wada, T; Yahagi, N; Yasunaga, H | 1 |
| Albers, EL; Dickey, R; Falconer, A; Jefferis Kirk, C; Latham, GJ; McMullan, DM | 1 |
| Fujimori, Y; Katagiri, H; Murata, M; Ohira, K; Shimizu, N; Wakui, M | 1 |
| Imoto, K; Isoda, S; Karube, N; Masuda, M; Matsuki, Y; Uchida, K; Yasuda, S | 1 |
| Bek, MJ; Keyl, C; Trenk, D; Wiessner, M; Zimmer, E | 1 |
| Kobayashi, Y; Mano, T; Matsuo, K; Nishi, R | 1 |
| Alaniz, C; Chan, C; Dorsch, M; Jaynes, E; Pipe, S; Vu, N | 1 |
| Gates, C; Neave, L; Scully, M | 1 |
| Kyle, JA; Roberts, RA; Skelley, JW | 1 |
| Golovin, A; Kopylov, A; Pavlova, G; Ustinov, N; Zavyalova, E | 1 |
| Chen, W; Cui, M; Jing, R; Wang, H; Xu, L | 1 |
| Adams, DH; Evans, AS; Fischer, GW; Heller, J; Salter, BS; Trinh, MA; Weiner, MM | 1 |
| Arachchillage, DR; Baglin, T; Besser, M; Maclean, R; van Veen, JJ | 1 |
| Kopylov, AM; Ustinov, NB; Zav'yalova, EG | 1 |
| Akita, N; Asanuma, K; Asanuma, Y; Hasegawa, M; Hayashi, T; Nishimura, A; Oi, T; Okamoto, T; Sudo, A; Yoshida, K; Yoshikawa, T | 1 |
| Fredenburgh, JC; Leslie, BA; Stafford, AR; Weitz, JI; Yeh, CH | 1 |
| Beiderlinden, M; Brau, C; di Grazia, S; Treschan, TA; Wehmeier, M | 1 |
| Chang, JB; Karan, C; Quinnies, KM; Rand, JH; Realubit, R; Tatonetti, NP | 1 |
| Croci, E; Dentali, F; Giorgi-Pierfranceschi, M; Mumoli, N; Scarpioni, R | 1 |
| Nakano, H; Yamada, M; Yanase, D | 1 |
| Harada, MY; Hoang, DM; Ley, EJ; Margulies, DR; Mason, R; Murry, JS; Nuño, M; Sun, BJ; Volod, O; Zaw, AA | 1 |
| Kin, N; Mitomo, S; Naganuma, T; Nakamura, S | 1 |
| Chen, L; Feng, Q; He, Y; Xu, R; Yan, F; Zhao, Y | 1 |
| Bernard, M; Do, B; Ghermani, N; Karoui, M; Safta, F; Secrétan, PH; Yagoubi, N | 1 |
| Keyl, C; Lehane, C; Trenk, D; Zimmer, E | 1 |
| Hayashi, Y; Minamide, H; Ueno, M | 1 |
| Kang, KP; Kim, W; Lee, S; Lim, JH; Park, SK | 1 |
| Guy, S; Kitchen, S; Van Veen, JJ | 2 |
| Hirohata, A; Kataoka, K; Kimura, T; Kozuma, K; Morino, Y; Tanabe, K; Tobaru, T; Yasuda, S | 1 |
| Lei, BZ; Sendowski, M; Shatzel, JJ | 1 |
| Baumgarten, G; Kim, S; Koster, A; Riedel, R; Schewe, JC; Schmieder, A | 1 |
| Dager, WE; Roberts, AJ; Van Cott, EM | 2 |
| Alarcón Pérez, L; Duque González, P; Rodríguez Huerta, AM | 1 |
| Kolde, HJ; Seidel, H | 1 |
| Kwon, DI; Macias, D; Peterson, NR; Walker, PC | 1 |
| Laliberte, B; Reed, BN | 1 |
| Barreto, AD; Cai, C; Ford, GA; Grotta, JC; Pedroza, C; Rahbar, MH; Shen, L; Tyson, J | 1 |
| Male, C; van Ommen, CH; Young, G | 1 |
| Lan, X; Li, S; Sun, Z; Tang, Z; Xi, Y; Zhao, H | 1 |
| Guy, S; Kitchen, S; Van Veen, J | 1 |
| Abramov, D; Birks, E; Bitar, A; Lenneman, A; Massey, T; Slaughter, M; Vijayakrishnan, R | 1 |
| Lopez, ND; Sin, JH | 1 |
| Guo, Y; Huang, Z; Jia, L; Xing, G; Yun, X; Zou, Z | 1 |
| Bulani, Y; Sharma, SS | 1 |
| Ahmed, MI; Bethea, BT; Elliot, JW; Richardson, JB | 1 |
| Barreto, AD; Grotta, JC | 1 |
| Shah, NH | 1 |
| Aliabadi-Zuckermann, A; Dworschak, M; Felli, A; Holaubek, C; Opfermann, P; Panzer, S; Schiferer, A; Steinlechner, B; Wadowski, PP | 1 |
| Fan, Q; Yang, J; Zhang, L; Zhang, Z; Zheng, X | 1 |
| Gamberini, L; Laici, C; Loforte, A; Ravaioli, M; Siniscalchi, A | 1 |
| Blum, EC; Martz, CR; Nemeh, H; Selektor, Y; Smith, ZR; To, L | 1 |
| Guan, H; Liu, R; Xu, Z | 1 |
| Greinacher, A; Heid, J; Katus, HA; Müller, OJ | 1 |
| Gleichgerrcht, E; Lim, MY; Turan, TN | 1 |
| Alessi, MC; Boivin, G; Couture, C; Hamelin, MÈ; Jandrot-Perrus, M; Lê, VB; Rhéaume, C; Riteau, B | 1 |
| Banik, N; Beyer-Westendorf, J; Brachmann, J; Dohmen, PM; Eberle, S; Hankowitz, J; Klamroth, R; Kropff, S; Lindhoff-Last, E; Madlener, K; Müller, MM; Pötzsch, B; Schellong, S; Schindewolf, M; Steindl, J | 1 |
| Faraoni, D; Koster, A; Levy, JH | 1 |
| Kolodziejczyk-Czepas, J; Moniuszko-Szajwaj, B; Nowak, P; Oleszek, W; Sieradzka, M; Stochmal, A | 1 |
| Ananth, CV; D'Alton, ME; Eisenberger, AB; Friedman, AM; Sagaram, D; Siddiq, Z; Wright, JD | 1 |
| Bahlmann, A; Beiderlinden, M; Brezina, T; Görlinger, K; Kemper, J; Kienbaum, P; Schäfer, M; Seidel, H; Treschan, TA; Werner, P | 1 |
| Abdillah, JN; Chen, X; Hu, Q; Huang, L; Luo, W; Zhou, W | 1 |
| Gheysens, O; Goffin, KE; Hoylaerts, MF; Jacquemin, M; Liesenborghs, L; Peerlinck, K; Peetermans, M; Peetermans, WE; Vanassche, T; Verhaegen, J; Verhamme, P; Wijngaerden, EV | 1 |
| Abe, S; Mitaki, S; Oguro, H; Onoda, K; Takayoshi, H; Yamaguchi, S | 1 |
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| Ashida, S; Kojima, Y; Maezono, K; Nagakane, Y; Ogura, S; Tanaka, E; Yamamoto, Y | 1 |
| Chang, HT; Chu, HW; Huang, CC; Lai, PX; Mao, JY; Unnikrishnan, B; Wu, CW | 1 |
| Cornelius, CC; Cripps, MW; Gales, PE; Nakonezny, PA; Vazquez, N; Wey, JC | 1 |
| Al-Eidan, FAS; Alrawkan, S; Alshammary, H; Crowther, MA | 1 |
| Ascaso, M; Pereda, D; Quintana, E; Sandoval, E | 1 |
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| Boivin, G; Checkmahomed, L; Couture, C; Hamelin, MÈ; Jandrot-Perrus, M; Lê, BV; Venable, MC | 1 |
| Prince, M; Wenham, T | 1 |
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| Barreto, AD; Berekashvili, K; Blackburn, S; Chen, PR; Dannenbaum, M; Grotta, JC; Misra, V; Shen, L; Soomro, J | 1 |
| Ahadizadeh, EN; Buethe, DJ; Honda, K; Manzoor, NF; Merati, M; Mowry, SE; Semaan, M | 1 |
| Cho, YH; Chung, CR; Kim, YS; Lee, H; Suh, GY; Sung, K; Yang, JH | 1 |
| Arepally, GM; Chong, BH; Cines, DB; Cuker, A; Greinacher, A; Gruel, Y; Linkins, LA; Morgan, RL; Mustafa, RA; Rodner, SB; Santesso, N; Selleng, S; Warkentin, TE; Wex, A | 1 |
| Cao, Z; Han, X; Huang, X; Lin, J; Pu, Z; Ren, K; Sun, W; Tian, L; Wang, Y; Xu, J; Zhang, S; Zhou, W | 1 |
| Cave, A; Del Valle, S; Fernandes, P; Nagpal, D; O'Neil, M | 1 |
| Alessandri, B; Jussen, D; Kempski, O; Krämer, TJ; Krenzlin, H; Sakas, W | 1 |
| Abekura, Y; Arai, D; Ikeda, H; Ishii, A; Miyamoto, S; Nishi, H; Tabata, Y | 1 |
| Forman, DA; Mohanty, E; Nazir, S; Sheppard, JI; Warkentin, TE | 1 |
| Hage, A; Kiaii, B; Louzada, M | 1 |
| Donahue, KR; Succar, L; Sulaica, EM; Wanat, MA | 1 |
| Van Cott, EM; Villalba, JA | 1 |
| Dai, S; Dai, Y; Ning, J; Xie, X | 1 |
| Brauckmann, S; Effenberger-Neidnicht, K; Hartmann, M; Mayer, C; Nagel, M; Peters, J | 1 |
| Arays, R; McCarthy, P; Shmookler, AD | 1 |
| Arai, N; Matsumoto, T; Nogami, K; Ogiwara, K; Sasai, K; Shima, M | 1 |
| Dai, G; Liu, Q; Sun, L; Wang, C | 1 |
| Senoh, M; Sunami, K; Yokota, Y; Yoshioka, T | 1 |
| Kim, J; Lee, DH; Sung, JH; Yi, HJ | 1 |
| Beyer, JT; Fisher, S; Kiser, TH; Lind, SE; Trujillo, TC; Wempe, MF | 1 |
| Butler, A; Gudgin, E; Mindlina, I; Nelmes, E; Sharp, M; Thomas, W | 1 |
| Briski, MJ; Duewell, BE; Feih, JT; Rinka, JRG; Tawil, JN | 1 |
| Choi, S; Hong, SB; Kim, DK; Oh, DK | 1 |
| Gleason, AM; Poyant, JO | 1 |
| Chantarangkul, V; Clerici, M; Padovan, L; Peyvandi, F; Scalambrino, E; Tripodi, A | 1 |
| Allender, JE; Coons, JC; Cox, JF; DiDomenico, RJ; Jennings, DL; Johnson, D; Oliphant, CS; Reed, BN | 1 |
| Berlioz, B; Guru, PK; Kaseer, HS; Sanghavi, DK | 1 |
| Jindong, H; Na, L | 1 |
| Baerens, L; Bomberg, H; Enkel, J; Klingele, M; Schäfers, HJ; Speer, T | 1 |
| Wu, ZY; Yang, FQ; Yang, YY; Zhang, H | 1 |
| Artoni, A; Chantarangkul, V; Clerici, M; Padovan, L; Peyvandi, F; Scalambrino, E; Tripodi, A | 1 |
| Coba, VE; Dingman, JS; Peters, MA; Smith, ZR; To, L | 1 |
| Cho, WH; Kim, DH; Lee, SK; Yeo, HJ | 1 |
| Singh Lubana, S; Singh, N; Tsai, HM | 1 |
| Curtis, BR; Erdil, RM; Gilyard, SN; Knelson, EH; Leaf, RK; Malhotra, R; Puram, RV; Ranganathan, R; Van Beuningen, AM; Wallwork, R; Weber, BN | 1 |
| Chen, H; Pan, Y; Wang, Y; Yang, Y; Zhou, Z | 1 |
| Ambreen, S; Changal, KH; Mir, T; Smith, A | 1 |
| Arachchillage, DJ; Hall, D; Laffan, M; Passariello, M; Patel, BV; Remmington, C; Rosenberg, A; Xu, T | 1 |
| Chen, G; Ding, W; Li, K; Ma, D; Nansubuga, F; Wei, J; Weng, D; Wu, P; Yang, J; Yu, R | 1 |
| Liu, P; Liu, S; Lu, H; Ma, X; Wang, L; Wang, P; Wang, Y; Zhang, F | 1 |
| Chen, L; Chen, Y; Ding, Q; Feng, C; Feng, Z; Li, S; Liu, F; Liu, X; Liu, Y; Qiu, Y; Ren, X; Tian, C; Wei, Y; Ying, H; Yu, W; Zhao, Y; Zhou, T | 1 |
| Boyle, G; Buchholz, H; Cantor, RS; Conway, J; Fynn-Thompson, F; Griffiths, E; Hawkins, B; Lorts, A; Lytrivi, ID; Machado, D; May, L; Niebler, RA; Rossano, J; Sutcliffe, DL; VanderPluym, CJ | 1 |
| Akiyama, T; Gohma, I; Kohata, H; Kohno, M; Kumasawa, J; Nagata, T; Nishida, K; Ogawa, Y | 1 |
| Daniels, LM; Sagardia, LM | 1 |
| Enright, H; Fahy, A; McGlynn, F; McGrath, J; McHugh, J; Ryan, B; Varghese, C | 1 |
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| Barbar, T; Bhasin, A; Gerardine, S; Lamba, P; Leuprecht, L; Liu, F; Muthukumar, T; Neupane, SP; Salinas, T; Shankaranarayanan, D; Shimonov, D; Varma, E | 1 |
| Cai, D; Chen, S; He, J; Huang, P; Lai, Y; Liu, J; Sun, H; Zhou, L | 1 |
| Kawashima, M; Michiwaki, Y; Samura, K; Suehiro, E; Tabei, Y; Tanaka, T; Wakamiya, T | 1 |
| Baba, Y; Higashino, M; Kimura, A; Sasaki, T; Sunaga, T; Tanioka, T; Watanabe, T | 1 |
| Arnold, F; Biever, PM; Kalbhenn, J; Neumann-Haefelin, E; Rieg, S; Tanriver, Y; Walz, G; Westermann, L | 1 |
| Bergis, B; Chanson, N; Chassin, O; Drouot, S; Gleizes, O; Legris, N; Proulle, V; Ract, C; Walle, EM; Werner, M | 1 |
| Gan, X; Jiang, N; Song, J; Zhi, W; Zhu, Z | 1 |
| He, XY; Huang, P; Xu, M | 1 |
| Cai, G; Cao, X; Chen, X; Feng, Z; Li, J; Lin, S; Liu, C; Sun, X; Wang, Y; Wu, D; Wu, J; Zhang, L; Zhu, H | 1 |
| Lai, CMB; Lee, AYY; Smith, T | 1 |
| Chapman, K; Makhija, K; Prasad, R | 1 |
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| Colarossi, G; Hatam, N; Maffulli, N; Migliorini, F; Schnöring, H; Tingart, M; Trivellas, A | 1 |
| Bartlett, RH; Bellomo, TR; Jeakle, MA; Major, TC; Meyerhoff, ME | 1 |
| Fisser, C; Foltan, M; Lubnow, M; Lunz, D; Maier, LS; Malfertheiner, MV; Müller, T; Philipp, A; Winkler, M; Zeman, F | 1 |
| Bersinger, S; Lagarde, K; Marlu, R; Payen, JF; Pernod, G | 1 |
| Brodmann, M; Gary, T; Guetl, K; Raggam, RB; Schmid, J; Wölfler, A | 1 |
| Hou, X; Jin, C; Pan, C; Qi, D; Wang, X; Xue, J; Yang, Z | 1 |
| Cwikla, GM; Darko, W; Feldman, EA; Green, GR; Seabury, RW; Shtoyko, AN | 1 |
| Fu, G; Liu, Z; Wang, Y; Yin, L; Zhang, K | 1 |
| Austin Szwak, J; Cirbus, K; Simone, P | 1 |
| Geng, N; Li, J; Li, ZG; Liu, LY; Sun, ZR; Wang, PF; Yu, JC; Yuan, HC; Zhao, GC; Zhu, LN | 1 |
| Abou El Ela, A; Demarest, CT; Lyu, D; McMurry, KA; Millis, MA; Sharif, L; Wakeam, E | 1 |
| Chunara, Z; Guy, S; Hopkins, B; Kitchen, S; Stephenson-Brown, A; van Veen, JJ | 1 |
| Beyer-Westendorf, J; Brückner, L; Pietsch, J; Tiebel, O | 1 |
| Du, Y; He, L; Liu, Q; Wang, H; Wang, J; Xu, J; Xu, X | 1 |
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| Lutchman, C; Margolin, E; Qian, J | 1 |
| Antoku, Y; Koga, T; Nyuta, E; Sakai, T; Takemoto, M; Tsuchihashi, T; Ueno, J | 1 |
| González-Rodríguez, M; Lázaro-García, A; Llamas-Sillero, P; Martínez-Alfonzo, I; Tomás-Mallebrera, M; Velasco-Rodríguez, D; Vidal-Laso, R | 1 |
| Alberio, L; Barelli, S; Gleich, T; Gomez, FJ; Goodyer, M; Grandoni, F; Marchetti, M | 1 |
| Clerici, M; Peyvandi, F; Scalambrino, E; Tripodi, A | 1 |
| Koster, A; Morshuis, M; von Dossow, V; Warkentin, H | 1 |
| Chen, HS; Cui, Y; Hou, XW; Li, XQ; Tian, XF; Wang, XH; Zhou, ZH | 1 |
| Asmis, LM; Bachler, M; Fries, D; Koscielny, J; Lang, T; Nowak, H; Paulus, P; Schewe, JC; von Heymann, C | 1 |
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181 review(s) available for arginine and mci 9038
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
A strategy for a rational approach to designing synthetic selective inhibitors.
Topics: Animals; Arginine; Binding Sites; Butyrylcholinesterase; Chemical Phenomena; Chemistry, Physical; Cholinesterase Inhibitors; Drug Design; Humans; Molecular Structure; Pipecolic Acids; Structure-Activity Relationship; Sulfonamides; Thrombin; Trypsin; Trypsin Inhibitors | 1992 |
Molecular approaches to antithrombotic therapy.
Topics: Amino Acid Chloromethyl Ketones; Antithrombins; Arginine; Heparin; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Protease Inhibitors; Sulfonamides; Thrombin; Warfarin | 1992 |
Clinical application of the synthetic thrombin inhibitor, argatroban (MD-805).
Topics: Antibodies; Antithrombin III Deficiency; Antithrombins; Arginine; Blood Platelets; Heparin; Heparin Antagonists; Humans; Pipecolic Acids; Renal Dialysis; Sulfonamides; Thrombocytopenia | 1992 |
Proteases and their inhibitors: today and tomorrow.
Topics: Amino Acid Sequence; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Endopeptidases; Heparin; Hirudins; HIV Protease; HIV Protease Inhibitors; Humans; Molecular Sequence Data; Peptidyl-Dipeptidase A; Pipecolic Acids; Protease Inhibitors; Recombinant Proteins; Renin; Sulfonamides; Thrombin | 1991 |
[Artificial organs and thrombosis: hemodialysis].
Topics: Arginine; Blood Coagulation; Blood Coagulation Factors; Calcium; Gabexate; Guanidines; Heparin; Humans; Pipecolic Acids; Platelet Aggregation; Platelet Count; Renal Dialysis; Sulfonamides; Thrombosis | 1986 |
Thrombin and antithrombotic therapy in interventional cardiology.
Topics: Angioplasty, Balloon, Coronary; Animals; Antithrombins; Arginine; Coronary Disease; Fibrinolytic Agents; Heparin; Hirudin Therapy; Humans; Pipecolic Acids; Platelet Membrane Glycoproteins; Recurrence; Sulfonamides; Thrombin | 1994 |
In vitro and in vivo properties of synthetic inhibitors of thrombin: recent advances.
Topics: Animals; Antithrombins; Arginine; Drug Design; Humans; Pipecolic Acids; Protease Inhibitors; Sulfonamides; Thrombin; Thrombolytic Therapy; Tosylarginine Methyl Ester | 1993 |
Inhibitor binding to thrombin: x-ray crystallographic studies.
Topics: Amino Acid Sequence; Antithrombins; Arginine; Binding Sites; Crystallography, X-Ray; Dipeptides; Hirudins; Molecular Sequence Data; Molecular Structure; Pipecolic Acids; Piperidines; Sulfonamides; Thrombin | 1993 |
Argatroban: a synthetic thrombin inhibitor of low relative molecular mass.
Topics: Animals; Antithrombins; Arginine; Coronary Thrombosis; Humans; Pipecolic Acids; Sulfonamides | 1996 |
Clinical trials of conjunctive anticoagulant strategies in thrombolysis.
Topics: Anticoagulants; Antithrombins; Arginine; Blood Platelets; Clinical Trials as Topic; Epoprostenol; Heparin; Hirudin Therapy; Hirudins; Humans; Myocardial Infarction; Oligopeptides; Peptide Fragments; Pipecolic Acids; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Recombinant Proteins; Sulfonamides; Thrombin; Thrombolytic Therapy | 1996 |
Modulating platelet function with selective thrombin inhibitors.
Topics: Administration, Oral; Adult; Animals; Antithrombins; Arginine; Blood Platelets; Boron Compounds; Clinical Trials as Topic; Dogs; Drug Evaluation, Preclinical; Glycine; Hirudin Therapy; Hirudins; Humans; Naphthalenes; Oligopeptides; Peptide Fragments; Pipecolic Acids; Piperidines; Recombinant Proteins; Sulfonamides; Thrombin | 1996 |
Direct thrombin inhibitors: appraisal of the antithrombotic/hemorrhagic balance.
Topics: Antithrombins; Arginine; Clinical Trials, Phase III as Topic; Fibrinolytic Agents; Hemorrhage; Hirudin Therapy; Hirudins; Humans; Myocardial Infarction; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides | 1997 |
Clinical trials of direct thrombin inhibitors during invasive procedures.
Topics: Antithrombins; Arginine; Clinical Trials as Topic; Clinical Trials, Phase III as Topic; Endothelium, Vascular; Fibrinolytic Agents; Hirudin Therapy; Hirudins; Humans; Pipecolic Acids; Sulfonamides | 1997 |
Anticoagulation with Novastan (argatroban) in patients with heparin-induced thrombocytopenia and heparin-induced thrombocytopenia and thrombosis syndrome.
Topics: Antibodies; Antithrombins; Arginine; Heparin; Humans; Pipecolic Acids; Sulfonamides; Syndrome; Thrombocytopenia; Thrombosis | 1997 |
Application of argatroban, direct thrombin inhibitor, in heparin-intolerant patients requiring extracorporeal circulation.
Topics: Anticoagulants; Antithrombin III Deficiency; Antithrombins; Arginine; Contraindications; Extracorporeal Circulation; Granulocytes; Heparin; Humans; Leukocyte Elastase; Pipecolic Acids; Sulfonamides; Thrombocytopenia | 1997 |
Enzyme-controlling medicines: introduction.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Antithrombins; Arginine; Enzyme Inhibitors; Humans; Kallikreins; Phenylalanine; Pipecolic Acids; Sulfonamides; Tranexamic Acid | 1997 |
Novastan (brand of argatroban): a small-molecule, direct thrombin inhibitor.
Topics: Animals; Antithrombins; Arginine; Clinical Trials, Phase I as Topic; Drug Evaluation, Preclinical; Humans; Molecular Structure; Molecular Weight; Myocardial Infarction; Pipecolic Acids; Sulfonamides; Thrombolytic Therapy | 1997 |
Development of argatroban, a direct thrombin inhibitor, and its clinical application.
Topics: Anticoagulants; Antithrombins; Arginine; Cardiovascular Diseases; Drug Monitoring; Humans; Ischemic Attack, Transient; Molecular Weight; Pipecolic Acids; Sulfonamides | 1997 |
Effect of argatroban, a selective thrombin inhibitor, on animal models of cerebral thrombosis.
Topics: Acute Disease; Animals; Anticoagulants; Antithrombin III Deficiency; Antithrombins; Arginine; Disease Models, Animal; Extracorporeal Circulation; Intracranial Embolism and Thrombosis; Pipecolic Acids; Rats; Sulfonamides | 1997 |
Thrombin inhibitor design.
Topics: Anticoagulants; Antithrombins; Arginine; Binding Sites; Dipeptides; Drug Design; Humans; Models, Molecular; Oligopeptides; Pipecolic Acids; Piperidines; Platelet Aggregation Inhibitors; Structure-Activity Relationship; Sulfonamides; Thrombin | 1998 |
College of American Pathologists Conference XXXI on laboratory monitoring of anticoagulant therapy: the clinical use and laboratory monitoring of low-molecular-weight heparin, danaparoid, hirudin and related compounds, and argatroban.
Topics: Anticoagulants; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Drug Combinations; Drug Monitoring; Heparin; Heparin, Low-Molecular-Weight; Heparitin Sulfate; Hirudin Therapy; Hirudins; Humans; Pathology, Clinical; Pipecolic Acids; Sulfonamides; Thromboembolism | 1998 |
[Heparin-induced thrombocytopenia].
Topics: Anticoagulants; Antithrombins; Arginine; Aspirin; Diagnosis, Differential; Fibrinolytic Agents; Heparin; Humans; Pipecolic Acids; Platelet Activation; Platelet Aggregation Inhibitors; Sulfonamides; Thrombocytopenia; Thrombosis | 1998 |
New treatment options for heparin-induced thrombocytopenia.
Topics: Anticoagulants; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Drug Combinations; Heparin; Heparitin Sulfate; Hirudin Therapy; Humans; Pipecolic Acids; Randomized Controlled Trials as Topic; Sulfonamides; Thrombocytopenia | 1998 |
[New antithrombotic drugs].
Topics: Abciximab; Antibodies, Monoclonal; Anticoagulants; Antithrombins; Arginine; Clinical Trials as Topic; Clinical Trials, Phase III as Topic; Dermatan Sulfate; Eptifibatide; Fibrinolytic Agents; Heparin, Low-Molecular-Weight; Hirudin Therapy; Hirudins; Humans; Immunoglobulin Fab Fragments; Multicenter Studies as Topic; Peptide Fragments; Peptides; Pilot Projects; Pipecolic Acids; Platelet Aggregation Inhibitors; Recombinant Proteins; Sulfonamides | 1999 |
Selectins in the HIT syndrome: pathophysiologic role and therapeutic modulation.
Topics: Anticoagulants; Antithrombins; Arginine; Hemostasis; Heparin; Humans; Models, Biological; Pipecolic Acids; Selectins; Sulfonamides; Syndrome; Thrombocytopenia | 1999 |
Heparin induced thrombocytopenia: diagnosis and contemporary antithrombin management.
Topics: Ancrod; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Drug Combinations; Fibrinolytic Agents; Forecasting; Gangrene; Hemorrhage; Heparin; Heparitin Sulfate; Hirudin Therapy; Hirudins; Humans; Pipecolic Acids; Platelet Aggregation; Protein C; Recombinant Proteins; Sulfonamides; Thrombin; Thrombocytopenia; Warfarin | 1999 |
[The role of immunologic reactions in the pathogenesis in Binswanger's disease; a clue to therapeutic approach].
Topics: Animals; Antithrombins; Arginine; Blood Coagulation Factors; Brain; Brain Ischemia; Cyclosporine; Dementia, Vascular; Humans; Immunosuppressive Agents; Neuroglia; Pipecolic Acids; Sulfonamides; Thrombin | 1999 |
Anticoagulant therapy in unstable angina.
Topics: Angina, Unstable; Anticoagulants; Antithrombins; Arginine; Clinical Trials as Topic; Coronary Thrombosis; Disease Progression; Heparin; Heparin, Low-Molecular-Weight; Hirudin Therapy; Hirudins; Humans; Myocardial Infarction; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Warfarin | 1999 |
[Therapeutic time window in ischemic stroke].
Topics: Animals; Arginine; Drug Therapy, Combination; Heparin; Humans; Methacrylates; Pipecolic Acids; Recombinant Proteins; Streptokinase; Stroke; Sulfonamides; Time Factors; Tissue Plasminogen Activator | 2000 |
Clinical application of argatroban as an alternative anticoagulant for extracorporeal circulation.
Topics: Animals; Anticoagulants; Arginine; Child; Extracorporeal Circulation; Heart Bypass, Left; Heparin; Humans; Pediatrics; Pipecolic Acids; Sulfonamides; Thromboembolism | 2000 |
Incarceration of the basilar artery in a longitudinal fracture of the clivus: case report and literature review.
Topics: Antithrombins; Arginine; Arterial Occlusive Diseases; Basilar Artery; Cranial Fossa, Posterior; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Pipecolic Acids; Respiration, Artificial; Skull Fractures; Sulfonamides; Tomography, X-Ray Computed; Treatment Outcome | 2000 |
Management of patients with heparin-induced thrombocytopenia: focus on recombinant hirudin.
Topics: Anticoagulants; Antithrombins; Arginine; Chondroitin Sulfates; Clinical Trials as Topic; Critical Pathways; Dermatan Sulfate; Drug Combinations; Fibrinolytic Agents; Heparin; Heparinoids; Heparitin Sulfate; Hirudin Therapy; Hirudins; Humans; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2000 |
Medical treatment for acute coronary syndromes.
Topics: Angina, Unstable; Arginine; Coronary Angiography; Fibrinolytic Agents; Heparin; Humans; Metalloendopeptidases; Myocardial Infarction; Pipecolic Acids; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Sulfonamides; Survival Rate; Syndrome; Thrombolytic Therapy; Tissue Plasminogen Activator | 2000 |
Argatroban for prevention and treatment of thromboembolism in heparin-induced thrombocytopenia.
Topics: Animals; Anticoagulants; Antithrombins; Arginine; Clinical Trials as Topic; Heparin; Humans; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Thromboembolism | 2001 |
Heparin induced thrombocytopenia thrombosis (HIT/T) syndrome: diagnosis and treatment.
Topics: Anticoagulants; Arginine; Heparin; Hirudin Therapy; Hirudins; Humans; Pipecolic Acids; Platelet Count; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Thrombosis | 2001 |
Advances in the development of thrombin inhibitors.
Topics: Arginine; Azetidines; Benzylamines; Clinical Trials as Topic; Glycine; Hirudin Therapy; Hirudins; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombin | 2001 |
Argatroban.
Topics: Animals; Antithrombins; Arginine; Clinical Trials as Topic; Half-Life; Humans; Pipecolic Acids; Sulfonamides; Thrombocytopenia | 2001 |
[Direct thrombin antagonists].
Topics: Acute Disease; Angina, Unstable; Angioplasty, Balloon, Coronary; Animals; Anticoagulants; Antithrombins; Arginine; Azetidines; Benzylamines; Fibrinolytic Agents; Glycine; Hirudin Therapy; Hirudins; Humans; Myocardial Infarction; Peptide Fragments; Pipecolic Acids; Platelet Aggregation Inhibitors; Rabbits; Recombinant Proteins; Sulfonamides; Syndrome; Thrombin; Thromboembolism; Thrombosis; Time Factors | 2001 |
Anticoagulation: the present and future.
Topics: Administration, Oral; Amino Acid Chloromethyl Ketones; Anticoagulants; Arginine; Azetidines; Benzylamines; Binding Sites; Biological Availability; Blood Coagulation; Comorbidity; Coumarins; Drug Design; Embolism; Female; Forecasting; Glycine; Guanidines; Heart Diseases; Hemorrhage; Heparin; Heparin, Low-Molecular-Weight; Hirudin Therapy; Humans; Neoplasms; Pipecolic Acids; Pregnancy; Pregnancy Complications, Hematologic; Prodrugs; Safety; Serine; Stroke; Sulfonamides; Thrombin; Thrombophilia; Thrombosis | 2001 |
Alternatives to unfractionated heparin for anticoagulation in cardiopulmonary bypass.
Topics: Abciximab; Ancrod; Antibodies, Monoclonal; Anticoagulants; Arginine; Cardiopulmonary Bypass; Chondroitin Sulfates; Cross Reactions; Dermatan Sulfate; Drug Combinations; Drug Hypersensitivity; Factor Xa Inhibitors; Hemodilution; Hemorrhage; Heparin; Heparin, Low-Molecular-Weight; Heparitin Sulfate; Hirudin Therapy; Humans; Immunoglobulin Fab Fragments; Perfusion; Pipecolic Acids; Platelet Aggregation Inhibitors; Protamines; Sulfonamides; Thrombocytopenia; Thrombophilia; Thrombosis; Tirofiban; Tyrosine | 2001 |
A synopsis of the clinical uses of argatroban.
Topics: Antithrombins; Arginine; Clinical Trials as Topic; Drug Interactions; Drug Therapy, Combination; Humans; Japan; Pipecolic Acids; Sulfonamides | 2001 |
Direct thrombin inhibitors in acute coronary syndromes: principal results of a meta-analysis based on individual patients' data.
Topics: Angina, Unstable; Antithrombins; Arginine; Glycine; Heparin; Hirudin Therapy; Hirudins; Humans; Myocardial Infarction; Oligopeptides; Peptide Fragments; Pipecolic Acids; Piperidines; Randomized Controlled Trials as Topic; Recombinant Proteins; Sulfonamides; Survival Rate; Thrombin | 2002 |
Treatment of heparin-induced thrombocytopenia.
Topics: Animals; Anticoagulants; Arginine; Chondroitin Sulfates; Clinical Trials as Topic; Coronary Disease; Dermatan Sulfate; Drug Combinations; Female; Heparin; Heparitin Sulfate; Hirudin Therapy; Hirudins; Humans; Pipecolic Acids; Pregnancy; Rabbits; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2002 |
Argatroban.
Topics: Animals; Antithrombins; Arginine; Clinical Trials as Topic; Humans; Pipecolic Acids; Renal Insufficiency; Sulfonamides; Thrombin; Thrombocytopenia | 2002 |
Direct thrombin inhibitors for percutaneous coronary intervention in the current era of platelet glycoprotein IIb/IIIa inhibition.
Topics: Angioplasty, Balloon, Coronary; Arginine; Coronary Thrombosis; Drug Therapy, Combination; Fibrinolytic Agents; Hirudin Therapy; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Recombinant Proteins; Sulfonamides | 2002 |
The role of thrombin inhibition during percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Arginine; Clinical Trials as Topic; Coronary Disease; Coronary Thrombosis; Fibrinolytic Agents; Fondaparinux; Heparin; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Sulfonamides; Thrombin | 2002 |
Therapeutic considerations in the management of patients with heparin-induced thrombocytopenia.
Topics: Anticoagulants; Arginine; Azetidines; Benzylamines; Fondaparinux; Heparin; Hirudin Therapy; Hirudins; Humans; Pipecolic Acids; Polysaccharides; Prodrugs; Recombinant Proteins; Sulfonamides; Thrombin; Thrombocytopenia | 2002 |
Role of thrombin in CNS damage associated with intracerebral haemorrhage: opportunity for pharmacological intervention?
Topics: Antithrombins; Arginine; Brain; Brain Edema; Cerebral Hemorrhage; Humans; Neurons; Pilot Projects; Pipecolic Acids; Sulfonamides; Survival Rate; Thrombin; Treatment Outcome | 2002 |
Current agents for the treatment of patients with heparin-induced thrombocytopenia.
Topics: Anticoagulants; Antithrombins; Arginine; Autoimmune Diseases; Chondroitin Sulfates; Dermatan Sulfate; Drug Combinations; Heparin; Heparitin Sulfate; Hirudin Therapy; Hirudins; Humans; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Warfarin | 2002 |
Antithrombotic drugs for the treatment of heparin-induced thrombocytopenia.
Topics: Animals; Anticoagulants; Antithrombins; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Drug Combinations; Fibrinolytic Agents; Heparin; Heparin, Low-Molecular-Weight; Heparitin Sulfate; Hirudins; Humans; Pipecolic Acids; Platelet Aggregation Inhibitors; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2002 |
[Experimental and clinical results with the thrombin inhibitor Argatroban].
Topics: Animals; Anticoagulants; Antithrombins; Arginine; Coronary Disease; Heparin; Humans; Pipecolic Acids; Sulfonamides; Thrombocytopenia | 2002 |
[Strategy for circulatory disturbance].
Topics: Abciximab; Antibodies, Monoclonal; Anticoagulants; Arginine; Aspirin; Clinical Trials as Topic; Heparin; Humans; Immunoglobulin Fab Fragments; Meta-Analysis as Topic; Pipecolic Acids; Platelet Aggregation Inhibitors; Streptokinase; Stroke; Sulfonamides; Thrombolytic Therapy; Tissue Plasminogen Activator; Urokinase-Type Plasminogen Activator | 2001 |
Hirudin in heparin-induced thrombocytopenia.
Topics: Anticoagulants; Antithrombins; Arginine; Blood Coagulation; Chondroitin Sulfates; Clinical Trials as Topic; Dermatan Sulfate; Drug Combinations; Fibrinolytic Agents; Heparin; Heparitin Sulfate; Hirudin Therapy; Hirudins; Humans; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Thrombosis; Time Factors | 2002 |
Direct thrombin inhibitors in cardiac disease.
Topics: Arginine; Coronary Disease; Fibrinolytic Agents; Hirudin Therapy; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Randomized Controlled Trials as Topic; Recombinant Proteins; Sulfonamides; Thrombin | 2003 |
Direct thrombin inhibitors.
Topics: Antithrombins; Arginine; Coronary Disease; Half-Life; Hirudins; Humans; Metabolic Clearance Rate; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombin; Venous Thrombosis | 2003 |
An overview of the direct thrombin inhibitor argatroban.
Topics: Arginine; Humans; Pipecolic Acids; Sulfonamides; Thrombin; Thrombocytopenia; Thrombosis; Treatment Outcome | 2002 |
Development of argatroban as an anticoagulant and antithrombin agent in Japan.
Topics: Anticoagulants; Arginine; Arterial Occlusive Diseases; Humans; Intracranial Thrombosis; Japan; Pipecolic Acids; Product Surveillance, Postmarketing; Renal Dialysis; Sulfonamides; Thrombin | 2002 |
Argatroban in thrombotic stroke.
Topics: Animals; Anticoagulants; Arginine; Brain Ischemia; Collateral Circulation; Humans; Pipecolic Acids; Stroke; Sulfonamides; Thrombin; Thrombosis | 2002 |
Argatroban in HIT type II and acute coronary syndrome.
Topics: Anticoagulants; Arginine; Cardiac Surgical Procedures; Coronary Disease; Humans; Myocardial Infarction; Pipecolic Acids; Sulfonamides; Thrombocytopenia | 2002 |
Practical issues in the development of argatroban: a perspective.
Topics: Animals; Anticoagulants; Arginine; Drug Interactions; Hemostasis; Humans; Pipecolic Acids; Rats; Sulfonamides; Therapeutic Equivalency; Thrombin | 2002 |
Management of heparin-induced thrombocytopenia: a critical comparison of lepirudin and argatroban.
Topics: Anticoagulants; Antithrombins; Arginine; Female; Heparin; Hirudins; Humans; Middle Aged; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2003 |
Direct thrombin inhibitors for non-ST-segment elevation acute coronary syndromes: what, when, and where?
Topics: Angioplasty, Balloon, Coronary; Arginine; Clinical Trials as Topic; Coronary Disease; Fibrinolytic Agents; Heparin; Hirudin Therapy; Hirudins; Humans; Myocardial Infarction; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Syndrome; Thrombin; Thrombolytic Therapy | 2003 |
Argatroban, a new treatment option for heparin-induced thrombocytopenia.
Topics: Anticoagulants; Antithrombins; Arginine; Blood Coagulation; Blood Coagulation Tests; Chondroitin Sulfates; Critical Care; Dermatan Sulfate; Drug Combinations; Drug Costs; Drug Monitoring; Heparin; Heparitin Sulfate; Hirudins; Humans; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2003 |
Treatment of heparin-induced thrombocytopenia: a critical review.
Topics: Anticoagulants; Arginine; Heparin; Hirudins; Humans; Pipecolic Acids; Recombinant Proteins; Risk Assessment; Sulfonamides; Thrombocytopenia; Thrombosis | 2004 |
Argatroban therapy for antithrombin deficiency and mesenteric thrombosis: case report and review of the literature.
Topics: Adult; Anticoagulants; Antithrombins; Arginine; Humans; Male; Partial Thromboplastin Time; Pipecolic Acids; Sulfonamides; Thrombosis | 2004 |
Direct thrombin inhibitors.
Topics: Anticoagulants; Arginine; Fibrinolytic Agents; Humans; Pipecolic Acids; Sulfonamides; Thrombin; Thrombosis; Warfarin | 2004 |
Small-molecule direct antithrombins: argatroban.
Topics: Animals; Antithrombins; Arginine; Hemostasis; Humans; Pipecolic Acids; Sulfonamides; Treatment Outcome; Vascular Diseases | 2004 |
[How to use anticoagulants in hemodialysis therapy].
Topics: Anticoagulants; Arginine; Benzamidines; Guanidines; Heparin; Heparin, Low-Molecular-Weight; Humans; Pipecolic Acids; Renal Dialysis; Sulfonamides | 2004 |
[Anticoagulant].
Topics: Animals; Anticoagulants; Antithrombins; Arginine; Benzamidines; Chondroitin Sulfates; Dermatan Sulfate; Drug Combinations; Drug Design; Enoxaparin; Extracorporeal Circulation; Guanidines; Heparin; Heparin, Low-Molecular-Weight; Heparinoids; Heparitin Sulfate; Humans; Pipecolic Acids; Protease Inhibitors; Protein C; Recombinant Proteins; Sorption Detoxification; Sulfonamides; Thrombomodulin | 2004 |
[Heparin-induced thrombocytopenia in patients on hemodialysis].
Topics: Anticoagulants; Arginine; Benzamidines; Guanidines; Heparin; Heparin, Low-Molecular-Weight; Humans; Pipecolic Acids; Renal Dialysis; Sulfonamides; Thrombocytopenia | 2004 |
[Prevention and treatment of deep vein thrombosis with ximelagatran].
Topics: Anticoagulants; Arginine; Azetidines; Benzylamines; Fondaparinux; Glycine; Heparin; Hirudin Therapy; Humans; Pipecolic Acids; Polysaccharides; Prodrugs; Sulfonamides; Thrombin; Venous Thrombosis | 2004 |
Direct thrombin inhibitors in the treatment of immune-mediated heparin-induced thrombocytopenia.
Topics: Anticoagulants; Arginine; Binding Sites; Heparin; Hirudins; Humans; Models, Biological; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Syndrome; Thrombin; Thrombocytopenia; Treatment Outcome | 2004 |
Percutaneous interventions in patients with immune-mediated heparin-induced thrombocytopenia.
Topics: Anticoagulants; Arginine; Blood Platelets; Heparin; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Skin; Sulfonamides; Thrombin; Thrombocytopenia; Time Factors | 2004 |
Heparin-induced thrombocytopenia: diagnosis and management.
Topics: Anticoagulants; Aortic Valve Insufficiency; Arginine; Autoantibodies; Autoimmune Diseases; Female; Fingers; Heart Valve Prosthesis Implantation; Heparin; Hirudins; Humans; Ischemia; Middle Aged; Necrosis; Pipecolic Acids; Platelet Activation; Platelet Factor 4; Postoperative Complications; Raynaud Disease; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Thrombosis; Toes; Warfarin | 2004 |
Heparin-induced thrombocytopenia in the cardiovascular patient: diagnostic and treatment guidelines.
Topics: Ancrod; Antibodies; Anticoagulants; Arginine; Cardiovascular Diseases; Chondroitin Sulfates; Dermatan Sulfate; Fibrinolytic Agents; Heparin; Heparin, Low-Molecular-Weight; Heparitin Sulfate; Hirudin Therapy; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Practice Guidelines as Topic; Purpura, Thrombocytopenic, Idiopathic; Recombinant Proteins; Sulfonamides; Thrombin | 2005 |
[Clinical guidelines for stroke].
Topics: Anticoagulants; Antipyrine; Arginine; Aspirin; Brain Edema; Edaravone; Fibrinolytic Agents; Free Radical Scavengers; Glycerol; Humans; Hyperlipidemias; Hypertension; Japan; Methacrylates; Pipecolic Acids; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk Factors; Stroke; Sulfonamides; Thrombolytic Therapy; Time Factors; Warfarin | 2004 |
Current role of antithrombotic agents in the treatment of acute coronary syndromes.
Topics: Aged; Anticoagulants; Arginine; Blood Platelets; Clinical Trials as Topic; Enoxaparin; Fibrinolytic Agents; Heparin, Low-Molecular-Weight; Hirudins; Humans; Middle Aged; Models, Biological; Myocardial Infarction; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Risk; Sulfonamides; Thrombin | 2004 |
Thrombin, an ideal target for pharmacological inhibition: a review of direct thrombin inhibitors.
Topics: Acute Disease; Angioplasty, Balloon, Coronary; Anticoagulants; Arginine; Atrial Fibrillation; Azetidines; Benzylamines; Clinical Trials as Topic; Coronary Disease; Heparin; Hirudins; Humans; Myocardial Infarction; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Syndrome; Thrombin; Thromboembolism; Thrombosis; Venous Thrombosis | 2005 |
Thrombin-directed inhibitors: pharmacology and clinical use.
Topics: Anticoagulants; Arginine; Azetidines; Benzylamines; Blood Coagulation; Fondaparinux; Heparin; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Sulfonamides; Thrombin; Thrombosis; Warfarin | 2005 |
Transition to an oral anticoagulant in patients with heparin-induced thrombocytopenia.
Topics: Administration, Oral; Anticoagulants; Arginine; Blood Coagulation; Blood Coagulation Factors; Chondroitin Sulfates; Dermatan Sulfate; Drug Combinations; Gangrene; Heparin; Heparitin Sulfate; Hirudins; Humans; Ischemia; Leg; Necrosis; Pipecolic Acids; Recombinant Proteins; Skin; Sulfonamides; Thrombocytopenia; Thrombosis; Warfarin | 2005 |
Alternative parenteral anticoagulation with argatroban, a direct thrombin inhibitor.
Topics: Anticoagulants; Arginine; Brain Ischemia; Clinical Trials as Topic; Dose-Response Relationship, Drug; Heparin; Humans; Pipecolic Acids; Platelet Aggregation Inhibitors; Risk Factors; Sulfonamides; Thrombin; Thrombocytopenia | 2005 |
Selective methodologies for the synthesis of biologically active piperidinic compounds.
Topics: Alkaloids; Arginine; Chemistry; Dioxoles; Paroxetine; Pipecolic Acids; Piperidines; Pyrrolidines; Sulfonamides | 2005 |
An anesthesia provider's perspective of heparin-induced thrombocytopenia.
Topics: Anesthesia, General; Anticoagulants; Arginine; Drug Monitoring; Enzyme-Linked Immunosorbent Assay; Heparin; Hirudins; Humans; Intraoperative Care; Nurse Anesthetists; Pipecolic Acids; Platelet Count; Recombinant Proteins; Risk Factors; Sensitivity and Specificity; Severity of Illness Index; Sulfonamides; Thrombocytopenia; Thrombosis; Time Factors | 2005 |
Heparin-induced thrombocytopenia: principles for early recognition and management.
Topics: Anticoagulants; Arginine; Heparin; Heparin, Low-Molecular-Weight; Hirudins; Humans; Pipecolic Acids; Platelet Count; Practice Guidelines as Topic; Recombinant Proteins; Risk Assessment; Sulfonamides; Thrombocytopenia; Time Factors | 2005 |
Direct thrombin inhibitors: pharmacology and clinical relevance.
Topics: Anticoagulants; Antithrombins; Arginine; Azetidines; Benzylamines; Fibrinolytic Agents; Hirudins; Humans; Pipecolic Acids; Sulfonamides; Thrombosis | 2005 |
[Nontraumatic arterial dissection of the anterior cerebral artery: six cases report].
Topics: Adult; Aged; Anterior Cerebral Artery; Anticoagulants; Aortic Dissection; Arginine; Brain Ischemia; Cerebral Angiography; Female; Humans; Hypertension; Infarction, Anterior Cerebral Artery; Intracranial Aneurysm; Magnetic Resonance Imaging; Male; Middle Aged; Pipecolic Acids; Prognosis; Subarachnoid Hemorrhage; Sulfonamides | 2005 |
Clinical presentation and laboratory diagnosis of heparin-induced thrombocytopenia.
Topics: Anticoagulants; Arginine; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Heparin, Low-Molecular-Weight; Hirudins; Humans; Male; Pipecolic Acids; Recombinant Proteins; Risk Assessment; Severity of Illness Index; Sulfonamides; Thrombocytopenia; Thrombosis; Treatment Outcome | 2005 |
[Heparin-induced thrombocytopenia (HIT): pathogenesis, laboratory test, and treatment].
Topics: Antibodies; Anticoagulants; Arginine; Biomarkers; Diagnosis, Differential; Enzyme-Linked Immunosorbent Assay; Heparin; Humans; Pipecolic Acids; Platelet Aggregation; Platelet Count; Platelet Factor 4; Sulfonamides; Thrombocytopenia | 2005 |
Evolving management strategies for heparin-induced thrombocytopenia.
Topics: Anticoagulants; Arginine; Fibrinolytic Agents; Heparin; Humans; Pipecolic Acids; Platelet Aggregation Inhibitors; Pulmonary Embolism; Sulfonamides; Thrombocytopenia; Warfarin | 2005 |
Anticoagulant use in patients with chronic renal impairment.
Topics: Anticoagulants; Arginine; Azetidines; Benzylamines; Fondaparinux; Heparin; Hirudins; Humans; Kidney Failure, Chronic; Peptide Fragments; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Sulfonamides; Warfarin | 2005 |
Developing an algorithm for treating heparin-induced thrombocytopenia.
Topics: Algorithms; Anticoagulants; Antigen-Antibody Complex; Arginine; Clinical Trials as Topic; Diagnosis, Differential; Disease Management; Follow-Up Studies; Hemorrhage; Heparin; Heparin, Low-Molecular-Weight; Hirudins; Humans; Immunoglobulin G; Pipecolic Acids; Platelet Activation; Platelet Count; Platelet Factor 4; Prognosis; Purpura, Thrombocytopenic, Idiopathic; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Thrombophilia; Time Factors | 2004 |
Heparin and other rapidly acting anticoagulants.
Topics: Anticoagulants; Arginine; Azetidines; Benzylamines; Embolism; Enzyme Inhibitors; Fondaparinux; Heparin; Heparin, Low-Molecular-Weight; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Sulfonamides; Thrombin; Thrombocytopenia; Venous Thrombosis | 2005 |
New trends in anticoagulant treatments.
Topics: Anticoagulants; Arginine; Azetidines; Benzylamines; Drug Design; Fibrinolytic Agents; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Platelet Aggregation Inhibitors; Prodrugs; Recombinant Proteins; Sulfonamides; Thrombosis | 2005 |
Argatroban, a direct thrombin inhibitor for heparin-induced thrombocytopaenia: present and future perspectives.
Topics: Animals; Antithrombins; Arginine; Forecasting; Heparin; Humans; Pipecolic Acids; Sulfonamides; Thrombocytopenia | 2006 |
[Argatroban: pharmacological properties and anaesthesiological aspects].
Topics: Anesthesia; Anticoagulants; Antithrombins; Arginine; Coronary Vessels; Critical Care; Extracorporeal Circulation; Heparin; Humans; Pipecolic Acids; Platelet Aggregation Inhibitors; Respiration, Artificial; Sulfonamides; Thrombocytopenia | 2006 |
Argatroban anticoagulation in pediatric patients: a literature analysis.
Topics: Anticoagulants; Arginine; Child; Humans; Pipecolic Acids; Sulfonamides; Thrombosis | 2006 |
Treatment of heparin-induced thrombocytopenia in cardiovascular patients.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Arginine; Cardiovascular Diseases; Chondroitin Sulfates; Dermatan Sulfate; Drug Administration Schedule; Factor Xa Inhibitors; Fondaparinux; Heparin; Heparitin Sulfate; Hirudins; Humans; Pipecolic Acids; Polysaccharides; Postoperative Complications; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Recombinant Proteins; Sulfonamides; Thrombin; Thrombocytopenia | 2006 |
Safety and efficacy of argatroban in patients with heparin-induced thrombocytopenia.
Topics: Angioplasty, Balloon, Coronary; Arginine; Heparin; Humans; Pipecolic Acids; Sulfonamides; Thrombocytopenia | 2006 |
Argatroban: a direct thrombin inhibitor with reliable and predictable anticoagulant actions.
Topics: Animals; Anticoagulants; Arginine; Blood Coagulation; Drug Monitoring; Humans; Intracranial Thrombosis; Pipecolic Acids; Randomized Controlled Trials as Topic; Stroke; Sulfonamides; Thrombin; Thrombocytopenia | 2006 |
Recognition and management of heparin-induced thrombocytopenia in pediatric cardiopulmonary bypass patients.
Topics: Adolescent; Anticoagulants; Arginine; Autoantibodies; Cardiopulmonary Bypass; Child; Child, Preschool; Clinical Trials as Topic; Fatal Outcome; Female; Heart Defects, Congenital; Heparin; Hirudins; Hospitals, University; Humans; Hypoplastic Left Heart Syndrome; Infant; Infant, Newborn; Male; Multicenter Studies as Topic; Pipecolic Acids; Platelet Factor 4; Postoperative Complications; Postoperative Hemorrhage; Recombinant Proteins; Retrospective Studies; Sulfonamides; Thrombocytopenia; Thromboembolism; Treatment Outcome | 2006 |
Argatroban: update.
Topics: Animals; Anticoagulants; Arginine; Clinical Trials as Topic; Humans; Pipecolic Acids; Sulfonamides | 2006 |
[Pharmacotherapy: argatroban--alternative to heparin in case of heparin-induced thrombocytopenia type II (HIT II)].
Topics: Anticoagulants; Arginine; Heparin; Humans; Pipecolic Acids; Sulfonamides; Thrombocytopenia | 2006 |
Heparin-induced thrombocytopenia and cardiovascular diseases.
Topics: Anticoagulants; Arginine; Cardiac Surgical Procedures; Cardiovascular Diseases; Chondroitin Sulfates; Dermatan Sulfate; Diagnosis, Differential; Fondaparinux; Heparin; Heparitin Sulfate; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Platelet Aggregation Inhibitors; Platelet Factor 4; Polysaccharides; Recombinant Proteins; Sensitivity and Specificity; Sulfonamides; Thrombocytopenia; Thrombosis | 2006 |
[Advanced medical therapy in patients with acute ischemic stroke].
Topics: Administration, Oral; Anticoagulants; Antipyrine; Arginine; Aspirin; Drug Design; Edaravone; Fibrinolytic Agents; Genomics; Heparin; Humans; Infusions, Intravenous; Pipecolic Acids; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Stroke; Sulfonamides; Time Factors; Tissue Plasminogen Activator | 2006 |
Anticoagulation strategies for treatment of ischemic stroke and antiphospholipid syndrome: case report and review of the literature.
Topics: Anticoagulants; Antiphospholipid Syndrome; Arginine; Azathioprine; Brain Ischemia; Dexamethasone; Humans; Male; Middle Aged; Pipecolic Acids; Stroke; Sulfonamides; Warfarin | 2006 |
Heparin-induced thrombocytopenia in the critical care setting: diagnosis and management.
Topics: Anticoagulants; Arginine; Chondroitin Sulfates; Clinical Trials as Topic; Critical Care; Dermatan Sulfate; Heparin; Heparinoids; Heparitin Sulfate; Hirudins; Humans; Pipecolic Acids; Platelet Count; Recombinant Proteins; Risk Factors; Sulfonamides; Thrombin; Thrombocytopenia | 2006 |
Heparin-induced thrombocytopenia: advances in diagnosis and treatment.
Topics: Administration, Oral; Anticoagulants; Arginine; Critical Care; Drug Monitoring; Enzyme-Linked Immunosorbent Assay; Heparin; Hirudins; Humans; International Normalized Ratio; Nurse's Role; Nursing Assessment; Partial Thromboplastin Time; Patient Selection; Pipecolic Acids; Platelet Count; Practice Guidelines as Topic; Recombinant Proteins; Risk Factors; Sulfonamides; Syndrome; Thrombocytopenia; Time Factors | 2006 |
Direct thrombin inhibition during percutaneous coronary intervention in patients with heparin-induced thrombocytopenia.
Topics: Angioplasty, Balloon, Coronary; Antithrombins; Arginine; Drug Interactions; Economics, Pharmaceutical; Fibrinolytic Agents; Hemorrhage; Heparin; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Platelet Aggregation Inhibitors; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Thrombosis | 2007 |
Heparin-induced thrombocytopenia without thrombosis: an evidence-based review of current literature.
Topics: Anticoagulants; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Evidence-Based Medicine; Heparin; Heparitin Sulfate; Hirudins; Humans; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2006 |
Alternative anticoagulation management strategies for the patient with heparin-induced thrombocytopenia undergoing cardiac surgery.
Topics: Ancrod; Anticoagulants; Arginine; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Chondroitin Sulfates; Dermatan Sulfate; Heparin; Heparin, Low-Molecular-Weight; Heparitin Sulfate; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Platelet Aggregation Inhibitors; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2007 |
Argatroban for anticoagulation during cardiac surgery.
Topics: Adult; Aged; Anticoagulants; Arginine; Cardiac Surgical Procedures; Coronary Artery Bypass; Coronary Artery Bypass, Off-Pump; Drug Monitoring; Endocarditis, Bacterial; Female; Heart Valve Prosthesis Implantation; Heparin; Humans; Intra-Aortic Balloon Pumping; Intraoperative Complications; Male; Middle Aged; Mitral Valve; Pipecolic Acids; Postoperative Complications; Retrospective Studies; Staphylococcal Infections; Subclavian Vein; Sulfonamides; Thrombosis; Venous Thrombosis; Warfarin; Whole Blood Coagulation Time | 2007 |
Heparin-induced thrombocytopenia in intensive care patients.
Topics: Anticoagulants; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Extracorporeal Circulation; Heparin; Heparitin Sulfate; Hirudins; Humans; Intensive Care Units; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombin; Thrombocytopenia; Thrombosis | 2007 |
Heparin-induced thrombocytopenia: treatment options and special considerations.
Topics: Anticoagulants; Antithrombins; Arginine; Heparin; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Thrombosis | 2007 |
Essentials of anticoagulation in hemodialysis.
Topics: Anticoagulants; Arginine; Blood Coagulation; Chondroitin Sulfates; Dermatan Sulfate; Equipment Failure; Hemorrhage; Heparin; Heparitin Sulfate; Hirudins; Humans; Pipecolic Acids; Recombinant Proteins; Renal Dialysis; Renal Insufficiency, Chronic; Sulfonamides | 2007 |
[Argatroban].
Topics: Anticoagulants; Arginine; Cerebral Infarction; Humans; Pipecolic Acids; Platelet Aggregation Inhibitors; Sulfonamides | 2006 |
Anticoagulation options for patients with heparin-induced thrombocytopenia requiring renal support in the intensive care unit.
Topics: Acute Kidney Injury; Anticoagulants; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Extracorporeal Circulation; Heparin; Heparitin Sulfate; Hirudin Therapy; Humans; Intensive Care Units; Pipecolic Acids; Renal Replacement Therapy; Sulfonamides; Thrombocytopenia | 2007 |
Heparin-induced thrombocytopenia and thrombosis.
Topics: Anticoagulants; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Heparin; Heparitin Sulfate; Hirudins; Humans; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Thrombosis | 2007 |
Heparin induced thrombocytopenia: diagnosis and management update.
Topics: Anticoagulants; Arginine; Cardiovascular Surgical Procedures; Chondroitin Sulfates; Dermatan Sulfate; Fibrinolytic Agents; Hemorrhage; Heparin; Heparitin Sulfate; Hirudins; Humans; Pipecolic Acids; Recombinant Proteins; Renal Dialysis; Sulfonamides; Thrombocytopenia; Warfarin | 2007 |
Percutaneous coronary interventions in patients with heparin-induced thrombocytopenia.
Topics: Algorithms; Angioplasty, Balloon, Coronary; Anticoagulants; Arginine; Chondroitin Sulfates; Comorbidity; Dermatan Sulfate; Drug Therapy, Combination; Fibrinolytic Agents; Fondaparinux; Heparin; Heparinoids; Heparitin Sulfate; Hirudins; Humans; Myocardial Infarction; Peptide Fragments; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Sulfonamides; Syndrome; Thrombocytopenia; Vitamin K | 2007 |
Heparin induced thrombocytopenia: pathogenetic, clinical, diagnostic and therapeutic aspects.
Topics: Animals; Anticoagulants; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Heparin; Heparitin Sulfate; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Postoperative Complications; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2007 |
Anticoagulation for acute coronary syndromes: from heparin to direct thrombin inhibitors.
Topics: Acute Disease; Angina Pectoris; Angina, Unstable; Angioplasty, Balloon, Coronary; Anticoagulants; Arginine; Fondaparinux; Hemorrhage; Heparin; Heparin, Low-Molecular-Weight; Hirudins; Humans; Models, Molecular; Molecular Structure; Myocardial Ischemia; Peptide Fragments; Pipecolic Acids; Platelet Activation; Polysaccharides; Recombinant Proteins; Sulfonamides; Syndrome; Thrombin; Thrombosis | 2007 |
[Heparin-induced thrombocytopenia].
Topics: Anticoagulants; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Fibrinolytic Agents; Fondaparinux; Heparin; Heparitin Sulfate; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2007 |
The laboratory diagnosis and clinical management of patients with heparin-induced thrombocytopenia: an update.
Topics: Anticoagulants; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Enzyme-Linked Immunosorbent Assay; Factor Xa Inhibitors; Heparin; Heparitin Sulfate; Hirudins; Peptide Fragments; Pipecolic Acids; Platelet Factor 4; Platelet Function Tests; Recombinant Proteins; Sulfonamides; Thrombin; Thrombocytopenia | 2008 |
Heparins, low-molecular-weight heparins, and pentasaccharides: use in the older patient.
Topics: Aged; Anticoagulants; Arginine; Enoxaparin; Fondaparinux; Heparin; Heparin, Low-Molecular-Weight; Hirudins; Humans; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Sulfonamides | 2008 |
New anticoagulant agents: direct thrombin inhibitors.
Topics: Anticoagulants; Arginine; Atrial Fibrillation; Benzimidazoles; Dabigatran; Fibrinolytic Agents; Half-Life; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Pyridines; Recombinant Proteins; Stroke; Sulfonamides; Thrombin | 2008 |
Argatroban anticoagulation in renal dysfunction: a literature analysis.
Topics: Anticoagulants; Arginine; Comorbidity; Humans; Pipecolic Acids; Prevalence; Renal Insufficiency; Sulfonamides; Thrombosis; Treatment Outcome | 2008 |
Heparin-induced thrombocytopenia: a review of current pharmacologic treatment.
Topics: Anticoagulants; Antithrombin III; Arginine; Fondaparinux; Heparin; Hirudins; Humans; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Sulfonamides; Thrombin; Thrombocytopenia | 2008 |
Argatroban use in heparin-induced thrombocytopenia.
Topics: Anticoagulants; Arginine; Clinical Trials as Topic; Heparin; Humans; Liver; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Thromboembolism | 2008 |
Successful use of argatroban during the third trimester of pregnancy: case report and review of the literature.
Topics: Adult; Anticoagulants; Arginine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Gravidity; Humans; Infant, Newborn; Infusions, Intravenous; Pipecolic Acids; Pregnancy; Pregnancy Outcome; Pregnancy Trimester, Third; Purpura, Thrombocytopenic, Idiopathic; Sulfonamides; Treatment Outcome; Venous Thrombosis | 2008 |
Review: recent advances in argatroban-warfarin transition in patients with heparin-induced thrombocytopenia.
Topics: Anticoagulants; Arginine; Heparin; Humans; Pipecolic Acids; Sulfonamides; Thrombin; Thrombocytopenia; Warfarin | 2010 |
Heparin-induced thrombocytopenia: what clinicians need to know.
Topics: Anticoagulants; Arginine; Autoantibodies; Chondroitin Sulfates; Dermatan Sulfate; Drug Monitoring; Fondaparinux; Heparin; Heparitin Sulfate; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Platelet Count; Platelet Factor 4; Polysaccharides; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Thrombosis; Warfarin | 2009 |
Reducing harm associated with anticoagulation: practical considerations of argatroban therapy in heparin-induced thrombocytopenia.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Arginine; Dose-Response Relationship, Drug; Heparin; Humans; International Normalized Ratio; Partial Thromboplastin Time; Pipecolic Acids; Platelet Aggregation Inhibitors; Sulfonamides; Thrombocytopenia; Thrombosis | 2009 |
Heparin-induced thrombocytopenia. A contemporary clinical approach to diagnosis and management.
Topics: Anticoagulants; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Female; Heparin; Heparitin Sulfate; Hirudins; Humans; Male; Monitoring, Physiologic; Peptide Fragments; Pipecolic Acids; Platelet Aggregation Inhibitors; Platelet Count; Prognosis; Randomized Controlled Trials as Topic; Recombinant Proteins; Risk Factors; Safety Management; Severity of Illness Index; Sulfonamides; Survival Rate; Thrombocytopenia; Thrombosis; Time Factors | 2009 |
Argatroban: a review of its use in the management of heparin-induced thrombocytopenia.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Arginine; Heparin; Humans; Pipecolic Acids; Sulfonamides; Thrombin; Thrombocytopenia; Thrombosis | 2009 |
[Anticoagulation in critically ill patient].
Topics: Anticoagulants; Arginine; Biological Availability; Blood Coagulation Tests; Contraindications; Critical Care; Drug Monitoring; Heparin; Heparin, Low-Molecular-Weight; Humans; Pipecolic Acids; Pulmonary Embolism; Risk Factors; Sepsis; Shock, Septic; Sulfonamides; Venous Thrombosis | 2009 |
Heparin-induced thrombocytopenia and cardiac surgery.
Topics: Anticoagulants; Arginine; Cardiovascular Surgical Procedures; Heparin; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Platelet Activation; Platelet Count; Platelet Factor 4; Recombinant Proteins; Sulfonamides; Thrombin; Thrombocytopenia | 2010 |
Heparin-induced thrombocytopenia: when a low platelet count is a mandate for anticoagulation.
Topics: Anticoagulants; Arginine; Autoantibodies; Contraindications; Disseminated Intravascular Coagulation; Fondaparinux; Heparin; Hirudins; Humans; Pipecolic Acids; Platelet Count; Platelet Factor 4; Polysaccharides; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Thrombophilia; Time Factors; Venous Thromboembolism; Vitamin K; Warfarin | 2009 |
Argatroban as a substitute of heparin during cardiopulmonary bypass: a safe alternative?
Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Arginine; Blood Coagulation; Cardiopulmonary Bypass; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Monitoring; Female; Heart Valve Prosthesis Implantation; Heparin; Humans; Infant; Infant, Newborn; Infusions, Intravenous; Male; Middle Aged; Pipecolic Acids; Postoperative Hemorrhage; Risk Assessment; Sulfonamides; Thrombin; Thrombocytopenia; Treatment Outcome | 2010 |
Laboratory monitoring of new anticoagulants.
Topics: Anticoagulants; Arginine; Blood Coagulation; Blood Coagulation Tests; Chromogenic Compounds; Drug Monitoring; Factor Xa Inhibitors; Humans; Pipecolic Acids; Sulfonamides; Thrombin; Warfarin | 2010 |
Argatroban in the management of heparin-induced thrombocytopenia.
Topics: Adult; Antithrombins; Arginine; Heparin; Humans; Pipecolic Acids; Randomized Controlled Trials as Topic; Sulfonamides; Thrombocytopenia | 2010 |
Pharmacotherapy in the critically ill obese patient.
Topics: Aminoglycosides; Antithrombins; Arginine; Body Mass Index; Carbapenems; Cephalosporins; Drug Dosage Calculations; Enoxaparin; Fibrinolytic Agents; Heparin; Humans; Hypnotics and Sedatives; Lipopeptides; Obesity; Oxazolidinones; Penicillins; Pipecolic Acids; Protein C; Quinolones; Recombinant Proteins; Safety; Sulfonamides; Vancomycin | 2010 |
Pharmacology of argatroban.
Topics: Acute Coronary Syndrome; Antithrombins; Arginine; European Union; Female; Heparin; Humans; Isomerism; Japan; Male; Peptidomimetics; Pipecolic Acids; Stroke; Sulfonamides; Thrombin; Thrombocytopenia; Thrombosis; United States | 2010 |
Direct thrombin inhibitors.
Topics: Anticoagulants; Antithrombins; Arginine; Benzimidazoles; Dabigatran; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Pyridines; Recombinant Proteins; Sulfonamides; Thrombin; Venous Thromboembolism | 2011 |
Thrombosis prophylaxis in critically ill patients.
Topics: Anticoagulants; Arginine; Biological Availability; Chromosome Breakage; Chromosome Disorders; Critical Care; Dose-Response Relationship, Drug; Drug Resistance; Heparin; Heparin, Low-Molecular-Weight; Hirudins; Humans; Infusions, Intravenous; Injections, Subcutaneous; Pipecolic Acids; Recombinant Proteins; Risk Factors; Sepsis; Severity of Illness Index; Shock, Septic; Sulfonamides; Thrombin; Thrombocytopenia; Venous Thrombosis | 2011 |
Direct thrombin and factor Xa inhibitors in children: a quest for new anticoagulants for children.
Topics: Adolescent; Anticoagulants; Arginine; Benzimidazoles; beta-Alanine; Child; Child, Preschool; Dabigatran; Drug Approval; Factor Xa Inhibitors; Fondaparinux; Hirudins; Humans; Infant; Infant, Newborn; Morpholines; Peptide Fragments; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Risk Factors; Rivaroxaban; Sulfonamides; Thiophenes; Thrombin; Venous Thromboembolism | 2011 |
An overview of heparin-induced thrombocytopenia.
Topics: Anticoagulants; Antithrombins; Arginine; Heparin; Humans; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Thrombosis; Time Factors | 2010 |
[Synthetic protease inhibitors for the treatment of DIC].
Topics: Anticoagulants; Arginine; Benzamidines; Disseminated Intravascular Coagulation; Gabexate; Guanidines; Humans; Pipecolic Acids; Protease Inhibitors; Sulfonamides | 2011 |
Old and new antithrombotic drugs in neonates and infants.
Topics: Anticoagulants; Arginine; Fondaparinux; Heparin, Low-Molecular-Weight; Hirudins; Humans; Infant; Infant, Newborn; Peptide Fragments; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Sulfonamides; Venous Thromboembolism; Warfarin | 2011 |
[Concept of branch atheromatous disease (BAD) and its clinical significance].
Topics: Antipyrine; Arginine; Cerebral Infarction; Cilostazol; Drug Therapy, Combination; Edaravone; Humans; Intracranial Arteriosclerosis; Ischemic Attack, Transient; Pipecolic Acids; Platelet Aggregation Inhibitors; Sulfonamides; Tetrazoles | 2010 |
Results of a consensus meeting on the use of argatroban in patients with heparin-induced thrombocytopenia requiring antithrombotic therapy - a European Perspective.
Topics: Anticoagulants; Antithrombins; Arginine; Dose-Response Relationship, Drug; Europe; Hematology; Heparin; Humans; Pipecolic Acids; Practice Guidelines as Topic; Sulfonamides; Thrombocytopenia; Treatment Outcome | 2012 |
Parenteral anticoagulants: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.
Topics: Antithrombins; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Dose-Response Relationship, Drug; Evidence-Based Medicine; Fibrinolytic Agents; Fondaparinux; Heparin; Heparin, Low-Molecular-Weight; Heparitin Sulfate; Hirudins; Humans; Infusions, Intravenous; Peptide Fragments; Pipecolic Acids; Polysaccharides; Practice Guidelines as Topic; Recombinant Proteins; Societies, Medical; Sulfonamides; Thrombin; Thrombosis; United States | 2012 |
Outcomes after heparin-induced thrombocytopenia in patients with Propaten vascular grafts.
Topics: Amputation, Surgical; Anticoagulants; Arginine; Blood Vessel Prosthesis; Blood Vessel Prosthesis Implantation; California; Coated Materials, Biocompatible; Device Removal; Drug Substitution; Graft Occlusion, Vascular; Heparin; Humans; Ligation; Pipecolic Acids; Prosthesis Design; Reoperation; Risk Assessment; Risk Factors; Sulfonamides; Thrombectomy; Thrombocytopenia; Treatment Outcome | 2012 |
Pharmacokinetic evaluation of argatroban for the treatment of acute coronary syndrome.
Topics: Acute Coronary Syndrome; Animals; Antithrombins; Arginine; Disease Models, Animal; Drug Evaluation; Heparin; Hirudins; Humans; Peptide Fragments; Percutaneous Coronary Intervention; Pipecolic Acids; Randomized Controlled Trials as Topic; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Thrombosis | 2012 |
Translational success stories: development of direct thrombin inhibitors.
Topics: Anticoagulants; Antithrombins; Arginine; Hirudin Therapy; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombosis; Translational Research, Biomedical | 2012 |
Ancillary approaches to plasminogen activators.
Topics: Anticoagulants; Arginine; Brain Ischemia; Cerebral Hemorrhage; Clinical Trials as Topic; Collateral Circulation; Drug Synergism; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Hypothermia, Induced; Low-Level Light Therapy; Pipecolic Acids; Plasminogen Activators; Platelet Aggregation Inhibitors; Prospective Studies; Recombinant Proteins; Sulfonamides; Thrombolytic Therapy; Tirofiban; Tyrosine; Ultrasonic Therapy; Vasodilator Agents | 2012 |
Argatroban: for a few selected patients.
Topics: Anticoagulants; Antithrombins; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Drug Interactions; Drug Substitution; Hemorrhage; Heparin; Heparitin Sulfate; Humans; Patient Selection; Pipecolic Acids; Risk Assessment; Risk Factors; Sulfonamides; Thrombocytopenia; Treatment Outcome; Venous Thrombosis | 2013 |
[Anticoagulation].
Topics: Administration, Oral; Anticoagulants; Antithrombins; Arginine; Arrhythmias, Cardiac; Blood Coagulation Tests; Factor Xa Inhibitors; Hemorrhage; Heparin; Heparinoids; Hirudins; Humans; Infusions, Intravenous; Orthopedic Procedures; Peptide Fragments; Pipecolic Acids; Postoperative Complications; Pulmonary Embolism; Recombinant Proteins; Risk Factors; Secondary Prevention; Sulfonamides; Thromboembolism; Treatment Outcome; Venous Thrombosis; Vitamin K | 2013 |
New developments in parenteral anticoagulation for arterial and venous thromboembolism.
Topics: Acute Coronary Syndrome; Antithrombins; Arginine; Fondaparinux; Hirudin Therapy; Hirudins; Humans; Infusions, Parenteral; Peptide Fragments; Percutaneous Coronary Intervention; Pipecolic Acids; Polysaccharides; Randomized Controlled Trials as Topic; Recombinant Proteins; Sulfonamides; Thrombin; Venous Thromboembolism | 2013 |
Management of anticoagulation in the critically ill patient.
Topics: Anticoagulants; Antithrombins; Arginine; Critical Illness; Heparin; Humans; Pipecolic Acids; Sulfonamides; Venous Thromboembolism | 2013 |
[Meta-analysis of the role of Argatroban in renal replacement therapy].
Topics: Antithrombins; Arginine; Hemorrhage; Humans; Incidence; Pipecolic Acids; Renal Dialysis; Renal Insufficiency; Renal Replacement Therapy; Sulfonamides; Thrombosis | 2013 |
[Concept, pathophysiology and treatment for branch atheromatous disease].
Topics: Antipyrine; Arginine; Cerebral Infarction; Cilostazol; Clopidogrel; Contraindications; Drug Therapy, Combination; Edaravone; Humans; Magnetic Resonance Imaging; Pipecolic Acids; Plaque, Atherosclerotic; Platelet Aggregation Inhibitors; Sulfonamides; Tetrazoles; Ticlopidine; Tissue Plasminogen Activator | 2014 |
Up to date concepts about Von Willebrand disease and the diagnose of this hemostatic disorder.
Topics: Arginine; Gene Components; Hemostasis; Humans; Models, Biological; Pipecolic Acids; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Sulfonamides; von Willebrand Diseases; von Willebrand Factor | 2014 |
CLINICAL PRACTICE. Heparin-Induced Thrombocytopenia.
Topics: Anticoagulants; Antithrombins; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Female; Heparin; Heparitin Sulfate; Humans; Middle Aged; Pipecolic Acids; Practice Guidelines as Topic; Sulfonamides; Thrombocytopenia | 2015 |
Anticoagulants in children and adolescents.
Topics: Adolescent; Anticoagulants; Arginine; Child; Clinical Trials as Topic; Fondaparinux; Hematology; Heparin; Heparin, Low-Molecular-Weight; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Sulfonamides; Thrombin; Thrombosis; Treatment Outcome; Warfarin | 2015 |
How we manage patients with heparin induced thrombocytopenia.
Topics: Anticoagulants; Arginine; Disease Management; Fondaparinux; Heparin; Humans; Pipecolic Acids; Polysaccharides; Sulfonamides; Thrombocytopenia; Warfarin | 2016 |
Novel oral anticoagulants for heparin-induced thrombocytopenia.
Topics: Administration, Oral; Anticoagulants; Arginine; Heparin; Humans; Pipecolic Acids; Sulfonamides; Thrombocytopenia | 2016 |
G-Quadruplex Aptamers to Human Thrombin Versus Other Direct Thrombin Inhibitors: The Focus on Mechanism of Action and Drug Efficiency as Anticoagulants.
Topics: Anticoagulants; Antithrombins; Aptamers, Nucleotide; Arginine; Blood Coagulation; G-Quadruplexes; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombin | 2016 |
Heparin-Induced Thrombocytopenia: A Comprehensive Clinical Review.
Topics: Anticoagulants; Antithrombins; Arginine; Cardiopulmonary Bypass; Fondaparinux; Heparin; Hirudins; Humans; Incidence; Peptide Fragments; Percutaneous Coronary Intervention; Pipecolic Acids; Plasmapheresis; Platelet Function Tests; Platelet Transfusion; Polysaccharides; Recombinant Proteins; Risk Factors; Sulfonamides; Thrombocytopenia | 2016 |
Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with lateral medullary syndrome: case report and literature review.
Topics: Aged; Antipyrine; Arginine; Clopidogrel; Diffusion Magnetic Resonance Imaging; Diuretics; Edaravone; Free Radical Scavengers; Furosemide; Humans; Hyponatremia; Inappropriate ADH Syndrome; Lateral Medullary Syndrome; Male; Pipecolic Acids; Platelet Aggregation Inhibitors; Sulfonamides; Ticlopidine | 2016 |
[Heparin-induced thrombocytopenia type II (HIT II) : A medical-economic view].
Topics: Arginine; Chondroitin Sulfates; Costs and Cost Analysis; Dermatan Sulfate; Germany; Hemorrhage; Heparin; Heparitin Sulfate; Hospitalization; Humans; Pipecolic Acids; Risk Factors; Sulfonamides; Thrombocytopenia; Thrombosis; Treatment Outcome | 2017 |
Laboratory Monitoring of Parenteral Direct Thrombin Inhibitors.
Topics: Antithrombins; Arginine; Drug Monitoring; Hirudins; Humans; Infusions, Parenteral; Partial Thromboplastin Time; Peptide Fragments; Pipecolic Acids; Point-of-Care Systems; Recombinant Proteins; Sulfonamides; Thrombin; Thrombin Time | 2017 |
Comparisons of argatroban to lepirudin and bivalirudin in the treatment of heparin-induced thrombocytopenia: a systematic review and meta-analysis.
Topics: Arginine; Female; Heparin; Hirudins; Humans; Male; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2017 |
Argatroban and Bivalirudin for Perioperative Anticoagulation in Cardiac Surgery.
Topics: Antithrombins; Arginine; Cardiac Surgical Procedures; Hirudins; Humans; Peptide Fragments; Perioperative Care; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombosis | 2018 |
Heparin-induced thrombocytopaenia.
Topics: Anticoagulants; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Fondaparinux; Heparin; Heparitin Sulfate; Humans; Pipecolic Acids; Polysaccharides; Sulfonamides; Thrombocytopenia | 2018 |
Management of Anticoagulation with Impella® Percutaneous Ventricular Assist Devices and Review of New Literature.
Topics: Anticoagulants; Arginine; Heart-Assist Devices; Humans; Pipecolic Acids; Shock, Cardiogenic; Sulfonamides | 2019 |
Thrombin Inhibition by Argatroban: Potential Therapeutic Benefits in COVID-19.
Topics: Antithrombins; Arginine; Blood Coagulation; COVID-19; COVID-19 Drug Treatment; Drug Development; Humans; Inflammation; Pipecolic Acids; SARS-CoV-2; Sulfonamides | 2021 |
Argatroban Anticoagulation for Adult Extracorporeal Membrane Oxygenation: A Systematic Review.
Topics: Adult; Anticoagulants; Arginine; Extracorporeal Membrane Oxygenation; Heparin; Humans; Pipecolic Acids; Prospective Studies; Sulfonamides | 2022 |
Superior outcomes with Argatroban for heparin-induced thrombocytopenia: a Bayesian network meta-analysis.
Topics: Anticoagulants; Arginine; Bayes Theorem; Heparin; Humans; Middle Aged; Network Meta-Analysis; Pipecolic Acids; Sulfonamides; Thrombocytopenia | 2021 |
Effects of argatroban therapy for stroke patients: A meta-analysis.
Topics: Arginine; Humans; Pipecolic Acids; Platelet Aggregation Inhibitors; Stroke; Sulfonamides | 2021 |
Thromboprophylaxis with argatroban in critically ill patients with sepsis: a review.
Topics: Anticoagulants; Arginine; COVID-19; Critical Illness; Heparin; Heparin, Low-Molecular-Weight; Humans; Pipecolic Acids; Sepsis; Sulfonamides; Thrombocytopenia; Thrombosis; Venous Thromboembolism | 2022 |
79 trial(s) available for arginine and mci 9038
| Article | Year |
|---|---|
Combined administration of aspirin and a specific thrombin inhibitor in man.
Topics: Adult; Antithrombins; Arginine; Aspirin; Bleeding Time; Blood Coagulation; Dose-Response Relationship, Drug; Drug Combinations; Humans; Male; Pipecolic Acids; Sulfonamides | 1991 |
Effects of an antithrombotic agent (MD-805) on progressing cerebral thrombosis.
Topics: Aged; Antithrombin III; Antithrombins; Arginine; Clinical Trials as Topic; Female; Humans; Infusions, Intravenous; Intracranial Embolism and Thrombosis; Male; Middle Aged; Partial Thromboplastin Time; Pipecolic Acids; Safety; Sulfonamides; Urokinase-Type Plasminogen Activator | 1989 |
Effect of argatroban on thrombus formation during acute coronary occlusion after balloon angioplasty.
Topics: Angioplasty, Balloon, Coronary; Antithrombins; Arginine; Coronary Thrombosis; Female; Humans; Male; Middle Aged; Pipecolic Acids; Sulfonamides; Thrombolytic Therapy; Urokinase-Type Plasminogen Activator | 1995 |
[Left heart bypass with the bio-medicus centrifugal pump by the use of an antithrombin agent, argatroban].
Topics: Adult; Aged; Antithrombins; Aortic Diseases; Arginine; Centrifugation; Heart Bypass, Left; Humans; Liver; Middle Aged; Pipecolic Acids; Platelet Count; Sulfonamides; Whole Blood Coagulation Time | 1994 |
Evidence for a rebound coagulation phenomenon after cessation of a 4-hour infusion of a specific thrombin inhibitor in patients with unstable angina pectoris.
Topics: Aged; Angina, Unstable; Antithrombin III; Antithrombins; Arginine; Blood Coagulation; Drug Administration Schedule; Female; Fibrinopeptide A; Humans; Infusions, Intravenous; Male; Middle Aged; Pipecolic Acids; Recurrence; Sulfonamides; Thrombin; Treatment Outcome | 1993 |
Inhibitory effect of argatroban on thrombin-antithrombin III complex after percutaneous transluminal coronary angioplasty.
Topics: Aged; Angioplasty, Balloon, Coronary; Antithrombin III; Antithrombins; Arginine; Biomarkers; Female; Heparin; Humans; Male; Myocardial Ischemia; Peptide Hydrolases; Pipecolic Acids; Sulfonamides; Thrombin; Thrombosis | 1995 |
Thrombin inhibition in the acute phase of ischaemic stroke using argatroban.
Topics: Aged; Antithrombins; Arginine; Brain Ischemia; Double-Blind Method; Female; Fibrin Fibrinogen Degradation Products; Glycerol; Humans; Male; Middle Aged; Partial Thromboplastin Time; Pipecolic Acids; Placebos; Reference Values; Sulfonamides; Thrombin; Thromboplastin | 1995 |
Additional anticoagulant strategies for managing heparin-induced thrombocytopenia.
Topics: Anticoagulants; Antithrombins; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Drug Combinations; Heparin; Heparitin Sulfate; Pipecolic Acids; Platelet Aggregation Inhibitors; Sulfonamides; Thrombocytopenia | 1996 |
Platelet activation with unfractionated heparin at therapeutic concentrations and comparisons with a low-molecular-weight heparin and with a direct thrombin inhibitor.
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Angina, Unstable; Anticoagulants; Antithrombins; Arginine; Dose-Response Relationship, Drug; Enoxaparin; Female; Heparin; Humans; Male; Middle Aged; P-Selectin; Partial Thromboplastin Time; Peptide Fragments; Pipecolic Acids; Platelet Activation; Platelet Count; Platelet Glycoprotein GPIIb-IIIa Complex; Sulfonamides | 1998 |
Effect of the thrombin inhibitor argatroban in acute cerebral thrombosis.
Topics: Acute Disease; Aged; Anticoagulants; Antithrombins; Arginine; Double-Blind Method; Female; Humans; Intracranial Embolism and Thrombosis; Male; Middle Aged; Pipecolic Acids; Sulfonamides | 1997 |
Clinical evaluation of the efficacy of an antithrombin agent "Argatroban" combined with exercise therapy on increase of the skeletal muscle blood flow.
Topics: Aged; Aged, 80 and over; Antithrombins; Arginine; Arteriosclerosis Obliterans; Blood Vessel Prosthesis Implantation; Combined Modality Therapy; Exercise Therapy; Humans; Male; Muscle, Skeletal; Pipecolic Acids; Prostaglandins E; Recurrence; Regional Blood Flow; Skin Temperature; Sulfonamides; Vasodilator Agents | 1996 |
Argatroban, an attractive anticoagulant, for left heart bypass with centrifugal pump for repair of traumatic aortic rupture.
Topics: Adolescent; Adult; Anticoagulants; Antithrombins; Aortic Rupture; Arginine; Drug Evaluation; Female; Heart Bypass, Left; Heart-Assist Devices; Humans; Male; Middle Aged; Multiple Trauma; Pipecolic Acids; Sulfonamides | 1999 |
Effect of thrombin inhibition in vascular dementia and silent cerebrovascular disease. An MR spectroscopy study.
Topics: Aged; Antithrombin III; Antithrombins; Arginine; Aspartic Acid; Biomarkers; Blood Coagulation; Brain Chemistry; Cerebral Cortex; Cerebrovascular Circulation; Cognition; Creatine; Dementia, Vascular; Enzyme Precursors; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Pipecolic Acids; Protons; Sulfonamides; Thrombin | 1999 |
Assessment of the potential pharmacokinetic and pharmacodynamic interactions between erythromycin and argatroban.
Topics: Adolescent; Adult; Analysis of Variance; Anti-Bacterial Agents; Antithrombins; Area Under Curve; Arginine; Cross-Over Studies; Drug Interactions; Erythromycin; Half-Life; Humans; Male; Middle Aged; Pipecolic Acids; Sulfonamides | 1999 |
A multicenter, randomized study of argatroban versus heparin as adjunct to tissue plasminogen activator (TPA) in acute myocardial infarction: myocardial infarction with novastan and TPA (MINT) study.
Topics: Adult; Arginine; Chemotherapy, Adjuvant; Coronary Angiography; Drug Therapy, Combination; Female; Fibrinolytic Agents; Follow-Up Studies; Heparin; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Pipecolic Acids; Platelet Aggregation Inhibitors; Recurrence; Single-Blind Method; Sulfonamides; Thrombolytic Therapy; Tissue Plasminogen Activator; Treatment Outcome | 1999 |
Argatroban increases nitric oxide levels in patients with peripheral arterial obstructive disease: placebo-controlled study.
Topics: Aged; Anticoagulants; Arginine; Arterial Occlusive Diseases; Female; Hemoglobins; Humans; Infusions, Intravenous; Male; Microcirculation; Middle Aged; Nitric Oxide; Pipecolic Acids; Sulfonamides | 1999 |
Clinical laboratory monitoring of a synthetic antithrombin agent, argatroban, using high performance liquid chromatography and functional methods.
Topics: Anticoagulants; Antithrombins; Arginine; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Monitoring; Drug Therapy, Combination; Hemorrhage; Humans; Male; Myocardial Infarction; Pipecolic Acids; Sensitivity and Specificity; Streptokinase; Sulfonamides; Time Factors | 1999 |
Clinical experience of Argatroban for anticoagulation in cardiovascular surgery.
Topics: Aged; Anticoagulants; Antithrombins; Arginine; Cardiovascular Surgical Procedures; Extracorporeal Circulation; Female; Fibrinolysis; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Platelet Aggregation; Postoperative Hemorrhage; Retrospective Studies; Sulfonamides | 2000 |
The pharmacokinetics and pharmacodynamics of argatroban: effects of age, gender, and hepatic or renal dysfunction.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anticoagulants; Area Under Curve; Arginine; Female; Humans; Kidney; Kidney Diseases; Liver; Liver Diseases; Male; Middle Aged; Minnesota; Pipecolic Acids; Prospective Studies; Quebec; Sex Factors; Sulfonamides; Texas | 2000 |
The regional cerebral blood flow amelioration of argatroban in the acute stage of cerebral thrombosis.
Topics: Acute Disease; Adult; Aged; Antithrombins; Arginine; Cerebrovascular Circulation; Female; Humans; Intracranial Thrombosis; Male; Middle Aged; Pipecolic Acids; Sulfonamides; Tomography, X-Ray Computed; Xenon | 2000 |
Antithrombotic treatment (argatroban vs. heparin) in coronary angioplasty in angina pectoris: effects on inflammatory, hemostatic, and endothelium-derived parameters.
Topics: Aged; alpha-2-Antiplasmin; Angina Pectoris; Angioplasty, Balloon, Coronary; Anticoagulants; Antithrombin III; Arginine; Aspirin; Biomarkers; Combined Modality Therapy; Endothelium, Vascular; Female; Fibrinolysin; Fibrinolytic Agents; Hemostasis; Heparin; Heparin Cofactor II; Humans; Inflammation; Male; Middle Aged; Peptide Fragments; Peptide Hydrolases; Pipecolic Acids; Plasminogen Activator Inhibitor 1; Plasminogen Activator Inhibitor 2; Platelet Count; Prothrombin; Sulfonamides; Tissue Plasminogen Activator; von Willebrand Factor | 2000 |
Comparison of anticoagulant effects and safety of argatroban and heparin in healthy subjects.
Topics: Adult; Anticoagulants; Arginine; Double-Blind Method; Half-Life; Heparin; Humans; Infusions, Intravenous; Male; Partial Thromboplastin Time; Pipecolic Acids; Sulfonamides; Whole Blood Coagulation Time | 2000 |
Effect of argatroban on trinitrobenzene sulfonic acid-induced colitis.
Topics: Analysis of Variance; Animals; Antithrombins; Arginine; Blood Coagulation Tests; Colitis; Disease Models, Animal; Heparin; Immunoenzyme Techniques; Infusion Pumps, Implantable; Leukotriene B4; Male; Nitrobenzenes; Peroxidase; Pipecolic Acids; Rats; Rats, Wistar; Sulfonamides; Sulfonic Acids | 2000 |
Argatroban and alteplase in patients with acute myocardial infarction: the ARGAMI Study.
Topics: Aged; Angiography; Anticoagulants; Arginine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Hemorrhage; Heparin; Humans; Male; Middle Aged; Myocardial Infarction; Partial Thromboplastin Time; Pipecolic Acids; Plasminogen Activators; Sulfonamides; Survival Rate; Time Factors; Tissue Plasminogen Activator | 2000 |
Argatroban anticoagulant therapy in patients with heparin-induced thrombocytopenia.
Topics: Aged; Anticoagulants; Arginine; Blood Coagulation; Blood Coagulation Tests; Diarrhea; Exanthema; Female; Hemorrhage; Heparin; Humans; Male; Middle Aged; Pain; Pipecolic Acids; Purpura; Sulfonamides; Thrombocytopenia; Treatment Outcome | 2001 |
Interpreting the International Normalized Ratio (INR) in individuals receiving argatroban and warfarin.
Topics: Adult; Anticoagulants; Arginine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Factor X; Hemostatics; Humans; International Normalized Ratio; Male; Middle Aged; Partial Thromboplastin Time; Pipecolic Acids; Sulfonamides; Thromboplastin; Warfarin | 2001 |
A specific thrombin inhibitor, argatroban, alleviates herpes zoster-associated pain.
Topics: Aged; Antithrombin III; Antithrombins; Arginine; Female; Herpes Zoster; Humans; Immunohistochemistry; Male; Middle Aged; Pain; Pain Measurement; Peptide Hydrolases; Pipecolic Acids; Prospective Studies; Prothrombin; Statistics, Nonparametric; Sulfonamides; Treatment Outcome; Up-Regulation | 2001 |
Investigation of the interaction between argatroban and acetaminophen, lidocaine, or digoxin.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anesthetics, Local; Antithrombins; Area Under Curve; Arginine; Confidence Intervals; Cross-Over Studies; Digoxin; Drug Interactions; Female; Half-Life; Humans; Lidocaine; Male; Metabolic Clearance Rate; Middle Aged; Pipecolic Acids; Sulfonamides | 2002 |
Anticoagulant therapy with a selective thrombin inhibitor for acute cerebral infarction: usefulness of coagulation markers for evaluation of efficacy.
Topics: Acute Disease; Aged; Anticoagulants; Antithrombins; Arginine; Biomarkers; Blood Coagulation; Blood Coagulation Tests; Blood Proteins; Cerebral Infarction; Embolism; Female; Hemorrhage; Humans; Male; Middle Aged; Pipecolic Acids; Stroke; Sulfonamides; Thrombosis; Treatment Outcome | 2002 |
Monitoring of argatroban in ARG310 study: potential recommendations for its use in interventional cardiology.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Arginine; Blood Coagulation; Blood Coagulation Tests; Chromatography, High Pressure Liquid; Drug Monitoring; Endopeptidases; Heparin; Humans; Pipecolic Acids; Point-of-Care Systems; Stents; Sulfonamides; Thrombocytopenia | 2002 |
Lack of pharmacokinetic interactions between argatroban and warfarin.
Topics: Adult; Analysis of Variance; Anticoagulants; Area Under Curve; Arginine; Drug Interactions; Female; Half-Life; Humans; Male; Metabolic Clearance Rate; Middle Aged; Pipecolic Acids; Sulfonamides; Warfarin | 2002 |
Argatroban anticoagulation in patients with acute ischemic stroke (ARGIS-1): a randomized, placebo-controlled safety study.
Topics: Aged; Anticoagulants; Arginine; Double-Blind Method; Drug Administration Schedule; Female; Humans; Intracranial Hemorrhages; Male; Middle Aged; Partial Thromboplastin Time; Pipecolic Acids; Stroke; Sulfonamides; Survival Analysis | 2004 |
Transition from argatroban to oral anticoagulation with phenprocoumon or acenocoumarol: effects on prothrombin time, activated partial thromboplastin time, and Ecarin Clotting Time.
Topics: Acenocoumarol; Administration, Oral; Adult; Anticoagulants; Arginine; Blood Coagulation; Blood Coagulation Tests; Drug Monitoring; Drug Therapy, Combination; Endopeptidases; Humans; International Normalized Ratio; Male; Partial Thromboplastin Time; Phenprocoumon; Pipecolic Acids; Prothrombin Time; Regression Analysis; Statistical Distributions; Sulfonamides | 2004 |
Local delivery of argatroban for the prevention of restenosis after coronary balloon angioplasty: a prospective randomized pilot study.
Topics: Aged; Angioplasty, Balloon; Arginine; Coronary Angiography; Coronary Disease; Coronary Restenosis; Female; Follow-Up Studies; Humans; Male; Middle Aged; Pipecolic Acids; Platelet Aggregation Inhibitors; Risk Factors; Sulfonamides; Time Factors | 2004 |
Pharmacokinetics and pharmacodynamics of argatroban in combination with a platelet glycoprotein IIB/IIIA receptor antagonist in patients undergoing percutaneous coronary intervention.
Topics: Aged; Algorithms; Angioplasty, Balloon, Coronary; Arginine; Female; Humans; Male; Middle Aged; Models, Statistical; Pipecolic Acids; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Sulfonamides; Whole Blood Coagulation Time | 2004 |
[Prospective randomized study of argatroban versus heparin anticoagulation therapy after percutaneous coronary intervention for acute myocardial infarction].
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Arginine; Coronary Restenosis; Heparin; Humans; Myocardial Infarction; Pipecolic Acids; Prospective Studies; Sulfonamides | 2004 |
A prospective comparison of three argatroban treatment regimens during hemodialysis in end-stage renal disease.
Topics: Adult; Aged; Anticoagulants; Arginine; Cross-Over Studies; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Pipecolic Acids; Prospective Studies; Renal Dialysis; Sulfonamides; Thrombosis | 2004 |
Use of the chromogenic factor X assay to predict the international normalized ratio in patients transitioning from argatroban to warfarin.
Topics: Aged; Anticoagulants; Arginine; Blood Coagulation; Chromogenic Compounds; Factor X; Female; Hospitals, University; Humans; International Normalized Ratio; Male; Middle Aged; Pipecolic Acids; Predictive Value of Tests; Prospective Studies; ROC Curve; Sulfonamides; Warfarin | 2005 |
Argatroban anticoagulation in patients with a history of heparin-induced thrombocytopenia.
Topics: Adult; Aged; Aged, 80 and over; Arginine; Coronary Disease; Female; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Pulmonary Embolism; Sulfonamides; Thrombocytopenia; Treatment Outcome; Venous Thrombosis | 2005 |
Transitioning from argatroban to warfarin therapy in patients with heparin-induced thrombocytopenia.
Topics: Anticoagulants; Arginine; Heparin; Humans; Infusions, Intravenous; International Normalized Ratio; Partial Thromboplastin Time; Pipecolic Acids; Platelet Count; Prospective Studies; Sulfonamides; Thrombocytopenia; Treatment Outcome; Warfarin | 2005 |
Transitioning from argatroban to warfarin in heparin-induced thrombocytopenia: an analysis of outcomes in patients with elevated international normalized ratio (INR).
Topics: Adult; Aged; Amputation, Surgical; Arginine; Cause of Death; Female; Hemorrhage; Heparin; Humans; Incidence; International Normalized Ratio; Male; Middle Aged; Pipecolic Acids; Retrospective Studies; Risk Assessment; Sulfonamides; Survival Rate; Thrombocytopenia; Thrombosis; Treatment Outcome; Warfarin | 2005 |
Argatroban anticoagulation in patients with heparin-induced thrombocytopenia requiring renal replacement therapy.
Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Anticoagulants; Arginine; Drug Administration Schedule; Female; Heparin; Humans; Kidney Failure, Chronic; Male; Middle Aged; Pipecolic Acids; Prospective Studies; Renal Replacement Therapy; Retrospective Studies; Sulfonamides; Thrombocytopenia; Treatment Outcome | 2005 |
Thrombocytopenia following heparin flush.
Topics: Amputation, Surgical; Anticoagulants; Arginine; Catheters, Indwelling; Cause of Death; Diagnosis, Differential; Female; Hemorrhage; Heparin; Humans; Infusions, Intravenous; Male; Middle Aged; Partial Thromboplastin Time; Patient Selection; Pipecolic Acids; Platelet Count; Prospective Studies; Recurrence; Sulfonamides; Therapeutic Irrigation; Thrombocytopenia; Thrombosis; Treatment Outcome | 2005 |
Argatroban tPA stroke study: study design and results in the first treated cohort.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arginine; Cerebral Hemorrhage; Cohort Studies; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Pipecolic Acids; Prospective Studies; Recombinant Proteins; Research Design; Stroke; Sulfonamides; Tissue Plasminogen Activator; Treatment Outcome | 2006 |
Anticoagulation with argatroban in patients with heparin-induced thrombocytopenia antibodies after cardiovascular surgery with cardiopulmonary bypass: first results from the ARG-E03 trial.
Topics: Antibodies; Anticoagulants; Arginine; Cardiopulmonary Bypass; Female; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Postoperative Care; Sulfonamides; Thrombocytopenia | 2006 |
Platelet activity, coagulation, and fibrinolysis during exercise in healthy males: effects of thrombin inhibition by argatroban and enoxaparin.
Topics: Adult; Anticoagulants; Arginine; Blood Coagulation; Blood Platelets; CD11b Antigen; Cross-Over Studies; Double-Blind Method; Enoxaparin; Exercise; Fibrinolysis; Humans; Leukocytes; Male; Pancreatic Elastase; Pipecolic Acids; Platelet Activation; Sulfonamides; Thrombin | 2007 |
Argatroban anticoagulation in critically ill patients.
Topics: Anticoagulants; Arginine; Critical Illness; Female; Hemorrhage; Heparin; Humans; Male; Middle Aged; Multiple Organ Failure; Partial Thromboplastin Time; Pipecolic Acids; Sulfonamides; Thrombocytopenia | 2007 |
Argatroban anticoagulation for heparin-induced thrombocytopenia in elderly patients.
Topics: Aged; Aged, 80 and over; Anticoagulants; Arginine; Creatine; Female; Heparin; Humans; Male; Partial Thromboplastin Time; Pipecolic Acids; Platelet Count; Risk Factors; Sulfonamides; Thrombocytopenia; Treatment Outcome | 2007 |
Argatroban therapy for heparin-induced thrombocytopenia in acutely ill patients.
Topics: Acute Disease; Aged; Anticoagulants; Arginine; Female; Heparin; Humans; International Normalized Ratio; Male; Middle Aged; Partial Thromboplastin Time; Pipecolic Acids; Platelet Aggregation Inhibitors; Platelet Count; Retrospective Studies; Safety; Sulfonamides; Thrombocytopenia; Treatment Outcome | 2007 |
[A study of the dosage of argatroban for anticoagulation effect in the patients undergoing high volume hemofiltration].
Topics: Anticoagulants; Arginine; Cross-Over Studies; Hemofiltration; Humans; International Normalized Ratio; Pipecolic Acids; Sulfonamides | 2009 |
The effect of argatroban on activated protein C resistance.
Topics: Activated Protein C Resistance; Adult; Aged; Aged, 80 and over; Anticoagulants; Arginine; Blood Coagulation; Female; Humans; Male; Middle Aged; Partial Thromboplastin Time; Pipecolic Acids; Sulfonamides | 2009 |
Low dose of argatroban saline flushes anticoagulation in hemodialysis patients with high risk of bleeding.
Topics: Anticoagulants; Arginine; Dose-Response Relationship, Drug; Female; Hemorrhage; Humans; Male; Middle Aged; Pipecolic Acids; Renal Dialysis; Sodium Chloride; Sulfonamides | 2010 |
Argatroban for elective percutaneous coronary intervention: the ARG-E04 multi-center study.
Topics: Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Anticoagulants; Antithrombins; Arginine; Blood Coagulation; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Hemorrhage; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Sulfonamides; Thrombosis | 2011 |
Rationale and design of the PREVENT-HIT study: a randomized, open-label pilot study to compare desirudin and argatroban in patients with suspected heparin-induced thrombocytopenia with or without thrombosis.
Topics: Anticoagulants; Arginine; Female; Heparin; Hirudins; Humans; Male; Pilot Projects; Pipecolic Acids; Prospective Studies; Recombinant Proteins; Research Design; Sulfonamides; Thrombocytopenia; Thrombosis | 2010 |
Anticoagulation with argatroban for elective percutaneous coronary intervention: population pharmacokinetics and pharmacokinetic-pharmacodynamic relationship of coagulation parameters.
Topics: Aged; Antithrombins; Arginine; Blood Coagulation; Blood Coagulation Tests; Dose-Response Relationship, Drug; Endovascular Procedures; Female; Heparin; Humans; Male; Middle Aged; Models, Statistical; Pipecolic Acids; Sulfonamides | 2011 |
A randomized, open-label pilot study comparing desirudin and argatroban in patients with suspected heparin-induced thrombocytopenia with or without thrombosis: PREVENT-HIT Study.
Topics: Adolescent; Adult; Aged; Anticoagulants; Arginine; Disease Progression; Female; Hemorrhage; Heparin; Hirudins; Humans; Male; Middle Aged; Pilot Projects; Pipecolic Acids; Platelet Count; Postoperative Complications; Postoperative Period; Recombinant Proteins; Sulfonamides; Thrombin; Thrombocytopenia; Thrombosis; Treatment Outcome; Young Adult | 2011 |
Evaluation of empiric versus nomogram-based direct thrombin inhibitor management in patients with suspected heparin-induced thrombocytopenia.
Topics: Adult; Aged; Antithrombins; Arginine; Empirical Research; Female; Heparin; Hirudins; Humans; Male; Middle Aged; Nomograms; Partial Thromboplastin Time; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2011 |
[Efficacy of regional administration of urokinase and argatroban via small saphenous vein catheter for treatment of acute deep venous thrombosis in the lower limb].
Topics: Adult; Arginine; Female; Fibrinolytic Agents; Humans; Injections, Intravenous; Lower Extremity; Male; Middle Aged; Pipecolic Acids; Saphenous Vein; Sulfonamides; Urokinase-Type Plasminogen Activator; Venous Thrombosis; Young Adult | 2011 |
Evaluation of a standardized protocol using lepirudin or argatroban for heparin-induced thrombocytopenia.
Topics: Aged; Anticoagulants; Antithrombins; Arginine; Female; Heparin; Hirudins; Humans; Male; Middle Aged; Partial Thromboplastin Time; Pipecolic Acids; Platelet Aggregation Inhibitors; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Treatment Outcome | 2011 |
Prognostic significance of smoking in patients with acute ischemic stroke within 3 months of onset.
Topics: Aged; Aged, 80 and over; Antipyrine; Arginine; Brain Ischemia; Chi-Square Distribution; Disability Evaluation; Drug Therapy, Combination; Edaravone; Female; Fibrinolytic Agents; Humans; Japan; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Pipecolic Acids; Recovery of Function; Risk Factors; Smoking; Smoking Cessation; Smoking Prevention; Stroke; Sulfonamides; Time Factors; Treatment Outcome | 2013 |
Bleeding risk factors associated with argatroban therapy in the critically ill.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arginine; Bilirubin; Critical Illness; Female; Hemoglobins; Hemorrhage; Humans; Male; Middle Aged; Pipecolic Acids; Platelet Aggregation Inhibitors; Platelet Count; Retrospective Studies; Risk Factors; Sulfonamides | 2012 |
Evaluation of 2 nomogram-based strategies for dosing argatroban in patients with known or suspected heparin-induced thrombocytopenia.
Topics: Aged; Antithrombins; Arginine; Female; Heparin; Humans; Male; Middle Aged; Nomograms; Pipecolic Acids; Sulfonamides; Thrombocytopenia | 2015 |
Effects of smoking on outcomes after acute atherothrombotic stroke in Japanese men.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antipyrine; Antithrombins; Arginine; Asian People; Body Temperature; Case-Control Studies; Edaravone; Humans; Logistic Models; Male; Pipecolic Acids; Retrospective Studies; Severity of Illness Index; Smoking; Stroke; Sulfonamides; Treatment Outcome; Young Adult | 2013 |
[Anticoagulant efficacy and safety of argatroban for patients undergoing elective percutaneous coronary intervention].
Topics: Adult; Anticoagulants; Arginine; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Pipecolic Acids; Sulfonamides; Treatment Outcome | 2013 |
Argatroban for preventing occlusion and restenosis after extracranial artery stenting.
Topics: Angiography, Digital Subtraction; Angioplasty; Antithrombins; Arginine; Carotid Stenosis; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Male; Middle Aged; Pilot Projects; Pipecolic Acids; Stents; Sulfonamides; Tomography, X-Ray Computed; Treatment Outcome; Vertebrobasilar Insufficiency | 2014 |
Argatroban versus Lepirudin in critically ill patients (ALicia): a randomized controlled trial.
Topics: Aged; Aged, 80 and over; Anticoagulants; Antithrombins; Arginine; Critical Illness; Female; Hemorrhage; Heparin; Hirudins; Humans; Male; Middle Aged; Partial Thromboplastin Time; Pipecolic Acids; Recombinant Proteins; Renal Insufficiency; Renal Replacement Therapy; Sulfonamides; Surgical Procedures, Operative; Thrombocytopenia | 2014 |
Argatroban in the management of heparin-induced thrombocytopenia: a multicenter clinical trial.
Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Arginine; Female; Heparin; Humans; Male; Middle Aged; Partial Thromboplastin Time; Pipecolic Acids; Platelet Count; Sulfonamides; Thrombocytopenia; Treatment Outcome | 2015 |
Argatroban pharmacokinetics and pharmacodynamics in critically ill cardiac surgical patients with suspected heparin-induced thrombocytopenia.
Topics: Aged; Aged, 80 and over; Antithrombins; Arginine; Cardiac Surgical Procedures; Critical Illness; Female; Half-Life; Heparin; Humans; Male; Middle Aged; Partial Thromboplastin Time; Pipecolic Acids; Prospective Studies; Sulfonamides; Thrombocytopenia | 2016 |
[Argatroban, Aspirin, and Clopidogrel Combination Therapy for Acute Penetrating Artery Infarction: A Pilot Study].
Topics: Acute Disease; Aged; Arginine; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Humans; Infarction; Male; Middle Aged; Pilot Projects; Pipecolic Acids; Platelet Aggregation Inhibitors; Prospective Studies; Stroke; Sulfonamides; Ticlopidine; Treatment Outcome | 2016 |
Randomized, Multicenter Trial of ARTSS-2 (Argatroban With Recombinant Tissue Plasminogen Activator for Acute Stroke).
Topics: Aged; Aged, 80 and over; Antithrombins; Arginine; Brain Ischemia; Cerebral Hemorrhage; Drug Therapy, Combination; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Outcome Assessment, Health Care; Pipecolic Acids; Severity of Illness Index; Stroke; Sulfonamides; Tissue Plasminogen Activator | 2017 |
Monitoring of argatroban and lepirudin anticoagulation in critically ill patients by conventional laboratory parameters and rotational thromboelastometry - a prospectively controlled randomized double-blind clinical trial.
Topics: Aged; Anticoagulants; Arginine; Blood Coagulation; Blood Coagulation Tests; Critical Illness; Double-Blind Method; Drug Monitoring; Female; Hirudins; Humans; Male; Middle Aged; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombelastography | 2018 |
Targeting Coagulase Activity in Staphylococcus aureus Bacteraemia: A Randomized Controlled Single-Centre Trial of Staphylothrombin Inhibition.
Topics: Administration, Intravenous; Administration, Oral; Aged; Aged, 80 and over; Anticoagulants; Antithrombins; Arginine; Bacteremia; Belgium; Blood Coagulation; Coagulase; Dabigatran; Enoxaparin; Feasibility Studies; Female; Hemorrhage; Humans; Injections, Subcutaneous; Male; Middle Aged; Partial Thromboplastin Time; Pilot Projects; Pipecolic Acids; Prospective Studies; Staphylococcal Infections; Staphylococcus aureus; Sulfonamides; Thrombin; Thrombosis; Time Factors; Treatment Outcome | 2018 |
Clinical study of argatroban for preventing vascular thrombosis in the early period after pediatric living-related donor liver transplantation.
Topics: Adolescent; Anticoagulants; Arginine; Child; Child, Preschool; Female; Heparin; Humans; Incidence; Infant; Infant, Newborn; Liver Transplantation; Living Donors; Male; Pipecolic Acids; Platelet Aggregation Inhibitors; Postoperative Care; Postoperative Complications; Sulfonamides; Thrombosis; Treatment Outcome | 2020 |
Randomized trial of argatroban plus recombinant tissue-type plasminogen activator for acute ischemic stroke (ARAIS): Rationale and design.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antithrombins; Arginine; Drug Therapy, Combination; Female; Humans; Intention to Treat Analysis; Male; Middle Aged; Pipecolic Acids; Single-Blind Method; Stroke; Sulfonamides; Tissue Plasminogen Activator; Young Adult | 2020 |
Efficiency and safety evaluation of prophylaxes for venous thrombosis after gynecological surgery.
Topics: Anticoagulants; Arginine; Endometrial Neoplasms; Female; Gynecologic Surgical Procedures; Heparin, Low-Molecular-Weight; Humans; Injections, Intravenous; Middle Aged; Ovarian Neoplasms; Pipecolic Acids; Postoperative Complications; Risk Factors; Sulfonamides; Uterine Cervical Neoplasms; Venous Thrombosis | 2020 |
Argatroban Increased the Basal Vein Drainage and Improved Outcomes in Acute Paraventricular Ischemic Stroke Patients.
Topics: Aged; Antithrombins; Arginine; Blood Flow Velocity; Brain Ischemia; Cerebral Veins; Drainage; Drug Therapy, Combination; Female; Humans; Ischemic Stroke; Male; Middle Aged; Pipecolic Acids; Sulfonamides; Tissue Plasminogen Activator | 2020 |
Effect of Argatroban Injection on Clinical Efficacy in Patients with Acute Cerebral Infarction: Preliminary Findings.
Topics: Activities of Daily Living; Arginine; Cerebral Infarction; Humans; Pipecolic Acids; Stroke; Sulfonamides; Treatment Outcome | 2021 |
Evaluating the safety and efficacy of argatroban locking solution in the prevention of the dysfunction of haemodialysis central venous catheters: a study protocol for a randomized controlled trial.
Topics: Arginine; Catheter-Related Infections; Central Venous Catheters; Heparin; Humans; Pipecolic Acids; Randomized Controlled Trials as Topic; Renal Dialysis; Sulfonamides | 2021 |
Safety and preliminary efficacy of argatroban plus dual antiplatelet therapy for acute mild to moderate ischemic stroke with large artery atherosclerosis.
Topics: Arginine; Arteries; Atherosclerosis; Hemorrhage; Humans; Intracranial Hemorrhages; Ischemic Stroke; Pipecolic Acids; Platelet Aggregation Inhibitors; Prospective Studies; Retrospective Studies; Sulfonamides; Treatment Outcome | 2022 |
728 other study(ies) available for arginine and mci 9038
| Article | Year |
|---|---|
Synthesis and nonthrombogenicity of polymer membrane with surface-graft polymers carrying thrombin inhibitor.
Topics: Acrylamides; Amino Acid Sequence; Animals; Antithrombins; Arginine; Blood Coagulation; Blood Coagulation Tests; Blood Grouping and Crossmatching; Dogs; Fibrin; Membranes, Artificial; Molecular Sequence Data; Molecular Structure; Pipecolic Acids; Platelet Adhesiveness; Platelet Aggregation; Polymers; Solutions; Sulfonamides; Surface Properties | 1992 |
Synergistic antithrombotic properties of G4120, a RGD-containing synthetic peptide, and argatroban, a synthetic thrombin inhibitor, in a hamster femoral vein platelet-rich thrombosis model.
Topics: Animals; Antithrombins; Arginine; Aspirin; Blood Coagulation; Cricetinae; Disease Models, Animal; Drug Synergism; Femoral Vein; Fibrinolytic Agents; Hemostasis; Heparin; Injections, Intravenous; Male; Peptides, Cyclic; Pipecolic Acids; Platelet Aggregation Inhibitors; Platelet Count; Sulfonamides; Sulfoxides; Thrombosis | 1992 |
Changes of rabbit platelet function following simultaneous administration of Ticlopidine hydrochloride and Argipidine (MD-805).
Topics: Animals; Antithrombin III; Antithrombins; Arginine; Fibrinogen; Fibrinolysin; Hematocrit; Pipecolic Acids; Platelet Aggregation; Platelet Count; Rabbits; Sulfonamides; Ticlopidine | 1992 |
Inhibition by fibrin coagulation of lung cancer cell destruction by human interleukin-2-activated killer cells.
Topics: Aged; Aged, 80 and over; Antithrombins; Arginine; Blood Coagulation; Cell Death; Cytotoxicity, Immunologic; Female; Fibrin; Fibrinogen; Humans; Immunity, Cellular; Interleukin-2; Killer Cells, Lymphokine-Activated; Kinetics; Leukocytes, Mononuclear; Lung Neoplasms; Male; Middle Aged; Pipecolic Acids; Sulfonamides; Thrombin | 1992 |
Experimental evaluation of coronary thrombodynamics and effects of pharmacological interventions in acute coronary syndromes.
Topics: Animals; Antithrombins; Arginine; Coronary Circulation; Coronary Thrombosis; Dogs; Heparin; Myocardial Infarction; Pipecolic Acids; Sulfonamides; Thiophenes; Thrombolytic Therapy; Thromboxane-A Synthase; Urokinase-Type Plasminogen Activator | 1992 |
Cellular mechanism of thrombin on endothelin-1 biosynthesis and release in bovine endothelial cell.
Topics: Animals; Arginine; Calcium; Cattle; Cells, Cultured; Dose-Response Relationship, Drug; Endothelin-1; Endothelins; Endothelium; Gene Expression Regulation; Inositol 1,4,5-Trisphosphate; Pipecolic Acids; Protein Precursors; RNA, Messenger; Sulfonamides; Thrombin | 1992 |
Treatment of heparin-induced thrombocytopenia by use of argatroban, a synthetic thrombin inhibitor.
Topics: Aged; Antithrombins; Arginine; Blood Platelets; Female; Heparin; Humans; Immunoglobulin G; Pipecolic Acids; Sulfonamides; Thrombocytopenia | 1992 |
Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics.
Topics: Amidines; Amino Acid Sequence; Animals; Antithrombins; Arginine; Benzamidines; Binding Sites; Cattle; Crystallography; Dipeptides; Fibrinolytic Agents; Hydrogen Bonding; Ligands; Models, Molecular; Molecular Sequence Data; Pipecolic Acids; Piperidines; Protein Conformation; Structure-Activity Relationship; Sulfonamides; Thrombin | 1992 |
Comparative antithrombotic effects of heparin, recombinant hirudin and argatroban in a hamster femoral vein platelet-rich mural thrombosis model.
Topics: Animals; Antithrombins; Arginine; Cricetinae; Femoral Vein; Heparin; Hirudin Therapy; Injections, Intravenous; Male; Models, Cardiovascular; Partial Thromboplastin Time; Pipecolic Acids; Sulfonamides; Thrombin Time; Thrombosis | 1992 |
Hereditary heparin cofactor II deficiency and coronary artery disease.
Topics: Angina Pectoris; Angiography; Angioplasty, Balloon, Coronary; Antithrombins; Arginine; Coronary Disease; Female; Heparin Cofactor II; Humans; Male; Middle Aged; Pedigree; Pipecolic Acids; Sulfonamides | 1992 |
Anticoagulant therapy in a congenital antithrombin III (ATIII)-deficient patient with chronic renal failure undergoing regular hemodialysis.
Topics: Adult; Antithrombin III; Antithrombin III Deficiency; Antithrombins; Arginine; Heparin; Humans; Kidney Failure, Chronic; Male; Peptide Hydrolases; Pipecolic Acids; Renal Dialysis; Sulfonamides | 1991 |
In vitro evaluation of sustained drug release from biodegradable elastomer.
Topics: Antithrombins; Arginine; Blood Coagulation; Cisplatin; Delayed-Action Preparations; Drug Implants; Humans; In Vitro Techniques; Magnetic Resonance Spectroscopy; Molecular Weight; Pharmaceutical Preparations; Pipecolic Acids; Polyesters; Rubber; Sulfonamides | 1991 |
Heparin and the thrombin inhibitor argatroban enhance fibrinolysis by infused or bolus-injected saruplase (r-scu-PA) in rabbit femoral artery thrombosis.
Topics: Animals; Anticoagulants; Antithrombins; Arginine; Drug Synergism; Drug Therapy, Combination; Enzyme Precursors; Femoral Artery; Fibrinolysis; Heparin; Infusions, Intravenous; Injections, Intravenous; Pipecolic Acids; Plasminogen Activators; Rabbits; Recombinant Proteins; Sulfonamides; Thrombosis; Urokinase-Type Plasminogen Activator | 1991 |
[Anticoagulant].
Topics: Acrylic Resins; Adsorption; Anticoagulants; Arginine; Benzamidines; Cellulose; Guanidines; Heparin; Humans; Membranes, Artificial; Permeability; Pipecolic Acids; Renal Dialysis; Sulfonamides | 1991 |
An evaluation of prothrombin assay method using MD805 by means of warfarin-treated plasma.
Topics: Adolescent; Adult; Antithrombins; Arginine; Benzamidines; Blood Coagulation Tests; Dipeptides; Guanidines; Humans; Pipecolic Acids; Prothrombin; Sulfonamides; Warfarin | 1991 |
[Thrombin.antithrombin III complex].
Topics: Antithrombin III; Antithrombins; Arginine; Biomarkers; Disseminated Intravascular Coagulation; Humans; Peptide Hydrolases; Pipecolic Acids; Sulfonamides | 1991 |
Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors.
Topics: Amino Acid Chloromethyl Ketones; Antithrombins; Arginine; Benzamidines; Binding Sites; Dipeptides; Humans; Models, Molecular; Pipecolic Acids; Piperidines; Stereoisomerism; Sulfonamides; Thrombin; Trypsin | 1991 |
Effect of ticlopidine and other antithrombotics on the venous thrombosis induced by endothelial damage of jugular vein in rats.
Topics: Animals; Arginine; Endothelium, Vascular; Fibrinolytic Agents; Freezing; Jugular Veins; Male; Microscopy, Electron, Scanning; Pipecolic Acids; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Inbred Strains; Sulfonamides; Thrombosis; Ticlopidine; Urokinase-Type Plasminogen Activator | 1991 |
The effect of heparin on multiple organ failure and disseminated intravascular coagulation in a sepsis model.
Topics: Animals; Antithrombins; Arginine; Blood Coagulation; Disease Models, Animal; Disseminated Intravascular Coagulation; Heparin; Infections; Male; Multiple Organ Failure; Pipecolic Acids; Rabbits; Sulfonamides | 1990 |
Comparative effects of aspirin, a synthetic thrombin inhibitor and a monoclonal antiplatelet glycoprotein IIb/IIIa antibody on coronary artery reperfusion, reocclusion and bleeding with recombinant tissue-type plasminogen activator in a canine preparation
Topics: Animals; Antibodies, Monoclonal; Antithrombins; Arginine; Aspirin; Coronary Circulation; Coronary Disease; Coronary Thrombosis; Dogs; Pipecolic Acids; Platelet Membrane Glycoproteins; Recurrence; Sulfonamides; Thrombolytic Therapy; Tissue Plasminogen Activator; Vascular Patency | 1990 |
Reperfusion, specific thrombin inhibition and reocclusion after thrombolysis.
Topics: Animals; Antibodies, Monoclonal; Antithrombins; Arginine; Coronary Disease; Coronary Thrombosis; Dogs; Pipecolic Acids; Platelet Membrane Glycoproteins; Recurrence; Sulfonamides; Thrombolytic Therapy; Tissue Plasminogen Activator | 1990 |
In vivo thrombin inhibition enhances and sustains arterial recanalization with recombinant tissue-type plasminogen activator.
Topics: Animals; Antithrombins; Arginine; Blood Coagulation Tests; Female; Femoral Artery; Male; Pipecolic Acids; Rabbits; Sulfonamides; Thrombolytic Therapy; Thrombosis; Tissue Plasminogen Activator | 1990 |
Prevention of reocclusion by MCI-9038, a thrombin inhibitor, following t-PA-induced thrombolysis in a canine model of femoral arterial thrombosis.
Topics: Animals; Arginine; Arterial Occlusive Diseases; Disease Models, Animal; Dogs; Femoral Artery; Hemodynamics; Male; Pipecolic Acids; Recurrence; Regional Blood Flow; Sulfonamides; Thrombin; Thrombin Time; Thrombolytic Therapy; Thrombosis; Tissue Plasminogen Activator | 1990 |
[Synthetic anticoagulant].
Topics: Animals; Antithrombins; Arginine; Dose-Response Relationship, Drug; Endothelins; Endothelium; Humans; Mice; Pipecolic Acids; Protein C; Receptors, Cell Surface; Receptors, Thrombin; Recombinant Proteins; Sulfonamides; Thrombosis | 1990 |
Geometry of binding of the benzamidine- and arginine-based inhibitors N alpha-(2-naphthyl-sulphonyl-glycyl)-DL-p-amidinophenylalanyl-pipe ridine (NAPAP) and (2R,4R)-4-methyl-1-[N alpha-(3-methyl-1,2,3,4-tetrahydro-8- quinolinesulphonyl)-L-arginyl]-2-piper
Topics: Animals; Antithrombins; Arginine; Binding Sites; Cattle; Computer Graphics; Crystallography; Dipeptides; Humans; In Vitro Techniques; Models, Molecular; Models, Structural; Molecular Conformation; Pipecolic Acids; Piperidines; Protein Binding; Structure-Activity Relationship; Sulfonamides; Thrombin; Trypsin; Trypsin Inhibitors; X-Ray Diffraction | 1990 |
Effect of a synthetic thrombin-inhibitor MD805 on the reaction between thrombin and plasma antithrombin-III.
Topics: Antithrombin III; Antithrombins; Arginine; Drug Interactions; Heparin; Humans; Peptide Hydrolases; Pipecolic Acids; Protein Binding; Sulfonamides; Thrombin; Thromboplastin | 1990 |
Prevention of platelet-rich arterial thrombosis by selective thrombin inhibition.
Topics: Animals; Antithrombins; Arginine; Arterial Occlusive Diseases; Bleeding Time; Blood Platelets; Femoral Artery; Graft Occlusion, Vascular; Heparin; In Vitro Techniques; Injections, Intra-Arterial; Injections, Intravenous; Pipecolic Acids; Rabbits; Regional Blood Flow; Sulfonamides; Thrombosis | 1990 |
A new method for the determination of prothrombin in human plasma.
Topics: Arginine; Blood Coagulation Factors; Enzyme Activation; Heparin; Humans; Pipecolic Acids; Prothrombin; Sulfonamides; Thrombin; Thromboplastin | 1990 |
Anticoagulant therapy with MD805 of a hemodialysis patient with heparin-induced thrombocytopenia.
Topics: Aged; Antithrombins; Arginine; Heparin; Humans; Male; Pipecolic Acids; Renal Dialysis; Sulfonamides; Thrombocytopenia | 1990 |
Role of thrombin and thromboxane A2 in reocclusion following coronary thrombolysis with tissue-type plasminogen activator.
Topics: Animals; Antithrombins; Arginine; Coronary Disease; Coronary Thrombosis; Disease Models, Animal; Dogs; Phospholipases; Phospholipases A; Pipecolic Acids; Platelet Aggregation; Reperfusion; Sulfonamides; Thrombin; Tissue Plasminogen Activator | 1989 |
Thrombin is an important mediator of platelet aggregation in stenosed canine coronary arteries with endothelial injury.
Topics: Animals; Antithrombin III; Arginine; Bridged Bicyclo Compounds, Heterocyclic; Coronary Circulation; Coronary Disease; Coronary Vessels; Dogs; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Fatty Acids, Unsaturated; Female; Hemodynamics; Heparin; Hydrazines; Ketanserin; Male; Peptide Hydrolases; Pipecolic Acids; Platelet Aggregation; Sulfonamides; Thrombin | 1989 |
Antithrombotic effects of three thrombin inhibitors in a rat model of laser-induced thrombosis.
Topics: Animals; Antithrombins; Arginine; Disease Models, Animal; Hirudins; Humans; Injections, Intravenous; Lasers; Light Coagulation; Pipecolic Acids; Rats; Rats, Inbred Strains; Sulfonamides; Thrombosis | 1989 |
Effect of a new anticoagulant (MD 805) on platelet activation in the hemodialysis circuit.
Topics: Adult; Aged; Anticoagulants; Arginine; beta-Thromboglobulin; Blood Platelets; Female; Heparin; Humans; Kidney Failure, Chronic; Male; Middle Aged; Pipecolic Acids; Platelet Factor 4; Renal Dialysis; Sulfonamides | 1986 |
Similarity and dissimilarity in the stereogeometry of the active sites of thrombin, trypsin, plasmin and glandular kallikrein.
Topics: Animals; Arginine; Binding Sites; Cattle; Enzyme Inhibitors; Fibrinolysin; Humans; Kallikreins; Pipecolic Acids; Structure-Activity Relationship; Sulfonamides; Thrombin; Tissue Kallikreins; Trypsin; Trypsin Inhibitors | 1987 |
Effect of synthetic thrombin inhibitor (MD805) as an alternative drug on heparin induced thrombocytopenia during hemodialysis.
Topics: Arginine; Blood Platelets; Heparin; Humans; Immunoglobulin G; Pipecolic Acids; Platelet Aggregation; Renal Dialysis; Sulfonamides; Thrombin; Thrombocytopenia | 1988 |
Thrombin is an important mediator of cyclic coronary blood flow variations due to platelet aggregation in stenosed canine coronary arteries.
Topics: Animals; Antithrombins; Arginine; Bridged Bicyclo Compounds, Heterocyclic; Coronary Circulation; Coronary Disease; Dogs; Fatty Acids, Unsaturated; Female; Heparin; Hydrazines; Ketanserin; Male; Pipecolic Acids; Platelet Aggregation; Sulfonamides; Thrombin; Thromboxane A2 | 1988 |
[Effects of a new synthetic anticoagulant (MD 805) on platelets].
Topics: Adult; Antithrombins; Arginine; Blood Platelets; Female; Heparin; Humans; Injections, Intravenous; Male; Pipecolic Acids; Sulfonamides | 1987 |
[Preventive effects of synthetic antithrombin, MD-805, on animal thrombosis models].
Topics: Acute Disease; Animals; Antithrombin III Deficiency; Antithrombins; Arginine; Arterial Occlusive Diseases; Mice; Pipecolic Acids; Pulmonary Embolism; Rats; Rats, Inbred Strains; Sulfonamides; Thrombosis; Vena Cava, Inferior | 1987 |
[Clinical evaluation of MD-805].
Topics: Aged; Antithrombins; Arginine; Disseminated Intravascular Coagulation; Drug Therapy, Combination; Female; Fibrinopeptide A; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Platelet Aggregation Inhibitors; Renal Dialysis; Sulfonamides; Thrombocytopenia; Thrombosis | 1987 |
[Treatment of cerebral infarction in the acute stage with synthetic antithrombin MD-805: a multicenter clinical study].
Topics: Antithrombins; Arginine; Cerebral Infarction; Drug Evaluation; Humans; Intracranial Embolism and Thrombosis; Pipecolic Acids; Sulfonamides | 1986 |
Effect of MD-805 on plasminogen activator release by thrombin from isolated perfused dog leg.
Topics: Animals; Arginine; Dogs; Fibrinolysis; Leg; Perfusion; Pipecolic Acids; Plasminogen Activators; Sulfonamides; Thrombin | 1987 |
Effect of a synthetic thrombin inhibitor MCI-9038 on experimental models of disseminated intravascular coagulation in rabbits.
Topics: Animals; Antithrombin III; Antithrombins; Arginine; Disseminated Intravascular Coagulation; Dose-Response Relationship, Drug; Fibrinogen; Heparin; Male; Partial Thromboplastin Time; Pipecolic Acids; Platelet Count; Rabbits; Sulfonamides; Thromboplastin | 1987 |
[A case of abdominal aortic aneurysm complicated with disseminated intravascular coagulation].
Topics: Adult; Aged; Aorta, Abdominal; Aortic Aneurysm; Arginine; Disseminated Intravascular Coagulation; Female; Humans; Male; Middle Aged; Pipecolic Acids; Sulfonamides | 1987 |
A new thrombin inhibitor MD805 and thrombocytopenia encountered with heparin hemodialysis.
Topics: Aged; Arginine; Female; Heparin; Humans; Middle Aged; Pipecolic Acids; Platelet Aggregation; Renal Dialysis; Sulfonamides; Thrombin; Thrombocytopenia; Thromboxane B2 | 1986 |
[Effect of MD-805, a synthetic thrombin inhibitor, on disseminated intravascular coagulation developing in hematological disorders].
Topics: Adult; Aged; Arginine; Disseminated Intravascular Coagulation; Female; Fibrinogen; Hematologic Diseases; Humans; Male; Middle Aged; Partial Thromboplastin Time; Pipecolic Acids; Sulfonamides; Thrombin | 1985 |
Antithrombogenic elastomers: novel anticoagulant/complement inhibitor-controlled release systems.
Topics: Animals; Anticoagulants; Arginine; Benzamidines; Biocompatible Materials; Delayed-Action Preparations; Guanidines; Pipecolic Acids; Polyurethanes; Rubber; Sulfonamides; Thrombin | 1985 |
Variation in activities of non-plasmin fibrinolytic proteinase and plasminogen-activator in the lung and spleen induced by bacterial endotoxin in rats with special reference to the effects of MD-805.
Topics: Animals; Arginine; Blood Coagulation Tests; Endopeptidases; Endotoxins; Escherichia coli; Female; Fibrinogen; Fibrinolytic Agents; Lipopolysaccharides; Lung; Pipecolic Acids; Plasminogen Activators; Platelet Count; Rats; Rats, Inbred Strains; Spleen; Sulfonamides; Thrombin | 1985 |
In vitro studies of a new synthetic thrombin inhibitor.
Topics: Arginine; Calcium; Humans; In Vitro Techniques; Pipecolic Acids; Platelet Adhesiveness; Platelet Aggregation; Sulfonamides; Thrombin | 1985 |
Thrombin-induced vasoconstriction in isolated cerebral arteries and the influence of a synthetic thrombin inhibitor.
Topics: Animals; Arginine; Cattle; Cerebral Arteries; Cerebrovascular Circulation; Dogs; In Vitro Techniques; Kinetics; Pipecolic Acids; Sulfonamides; Thrombin; Vasoconstriction | 1985 |
[Substitution of antithrombin III by synthetic thrombin inhibitors].
Topics: Animals; Antithrombin III; Antithrombin III Deficiency; Arginine; Carbon Tetrachloride Poisoning; Fibrinogen; Heparin; Phenylpyruvic Acids; Pipecolic Acids; Platelet Count; Rats; Sulfonamides; Thrombin; Thrombosis | 1984 |
[Studies on platelet aggregation induced by human cultured carcinoma cell lines].
Topics: Arginine; Cell Line; Cells, Cultured; Female; Humans; Lung Neoplasms; Membrane Proteins; Microbial Collagenase; Neoplasms; Neoplastic Cells, Circulating; Neuraminidase; Pipecolic Acids; Platelet Aggregation; Stomach Neoplasms; Sulfonamides; Trypsin | 1984 |
[Mathematical simulation of the blood coagulation system].
Topics: Adult; Anticoagulants; Antithrombin III; Antithrombin III Deficiency; Arginine; Blood Coagulation; Factor VII; Factor VIIa; Hemophilia A; Heparin; Humans; Male; Mathematics; Microcomputers; Models, Biological; Partial Thromboplastin Time; Pipecolic Acids; Prothrombin; Prothrombin Time; Sulfonamides | 1984 |
[Possibility of improvement of new cardiopulmonary bypass technique without heparin].
Topics: Arginine; Cardiopulmonary Bypass; Epoprostenol; Heparin; Humans; Pipecolic Acids; Prostaglandins, Synthetic; Sulfonamides; Thrombin; Ventilators, Mechanical | 1984 |
[Combined effects of PGI2 and thrombin inhibitors or fibrinolytic agent on platelet aggregation and disaggregation].
Topics: Arginine; Benzamidines; Calcium; Drug Synergism; Epoprostenol; Fibrinolytic Agents; Guanidines; Heparin; Humans; Pipecolic Acids; Platelet Aggregation; Sulfonamides; Urokinase-Type Plasminogen Activator | 1984 |
Anticoagulation with a synthetic thrombin inhibitor after cardiovascular surgery and for treatment of disseminated intravascular coagulation.
Topics: Adult; Aged; Antithrombin III; Arginine; Cardiovascular Diseases; Disseminated Intravascular Coagulation; Female; Gabexate; Guanidines; Humans; Male; Middle Aged; Pipecolic Acids; Postoperative Care; Sulfonamides | 1984 |
[Antinephritic effect of MD-805 [(2R, 4R) -4-methyl-[N2-(3-methyl-1,2,3,4-tetrahydro-8-quinolinesulfonyl) -L-arginyl] -2-piperidine-carboxylic acid monohydrate], a new antithrombin agent, on crescentic-type anti-GMB nephritis in rats].
Topics: Animals; Arginine; Basement Membrane; Blood Urea Nitrogen; Glomerulonephritis; Heparin; Kidney Glomerulus; Male; Pipecolic Acids; Rats; Rats, Inbred Strains; Sulfonamides; Thrombin; Urokinase-Type Plasminogen Activator | 1984 |
[Evaluation of a synthetic thrombin inhibitor MD 805 as an anticoagulant after open heart and vascular surgery].
Topics: Adult; Anticoagulants; Arginine; Cardiac Surgical Procedures; Female; Humans; Male; Middle Aged; Pipecolic Acids; Postoperative Care; Sulfonamides; Thrombin; Vascular Surgical Procedures | 1983 |
Clinical evaluation of a new thrombin inhibitor available for haemodialysis.
Topics: Arginine; Drug Evaluation; Female; Heparin; Humans; Male; Pipecolic Acids; Renal Dialysis; Sulfonamides; Thrombin | 1983 |
A clinical trial of MD-805, a synthetic thrombin inhibitor, for the treatment of DIC.
Topics: Antithrombins; Arginine; Chemical Phenomena; Chemistry; Child; Disseminated Intravascular Coagulation; Female; Fibrinogen; Humans; Meningoencephalitis; Partial Thromboplastin Time; Pipecolic Acids; Platelet Count; Prothrombin Time; Pseudomonas Infections; Sepsis; Sulfonamides; Thrombin | 1983 |
[Extracorporeal circulation without heparin. Studies of synthetic antithrombotic agent, MD805].
Topics: Animals; Arginine; Blood Platelets; Dogs; Extracorporeal Circulation; Fibrinolytic Agents; Hemodynamics; Pipecolic Acids; Sulfonamides | 1983 |
Inhibition of thrombin-induced platelet adherence to vascular cells by synthetic thrombin inhibitor No. 805.
Topics: Arginine; Blood Vessels; Cells, Cultured; Endothelium; Humans; Pipecolic Acids; Platelet Adhesiveness; Platelet Aggregation; Sulfonamides; Thrombin; Umbilical Arteries; Umbilical Veins | 1983 |
Selective inhibition of thrombin by (2R,4R)-4-methyl-1-[N2-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl++ +) sulfonyl]-l-arginyl)]-2-piperidinecarboxylic acid.
Topics: Animals; Arginine; Binding Sites; Binding, Competitive; Cattle; Kinetics; Optical Rotation; Pipecolic Acids; Stereoisomerism; Structure-Activity Relationship; Sulfonamides; Thrombin | 1984 |
Comparative study on heparin and a synthetic thrombin inhibitor no. 805 (MD-805*) in experimental antithrombin III-deficient animals.
Topics: Acute Disease; Animals; Antibodies, Anti-Idiotypic; Antigens; Antithrombin III; Arginine; Blood Coagulation Tests; Fibrinolytic Agents; Heparin; Male; Mice; Mice, Inbred Strains; Pipecolic Acids; Pulmonary Embolism; Rabbits; Rats; Rats, Inbred Strains; Sulfonamides; Thrombin; Thrombophlebitis | 1981 |
Potent inhibition of thrombin by the newly synthesized arginine derivative No. 805. The importance of stereo-structure of its hydrophobic carboxamide portion.
Topics: Arginine; Binding Sites; Kinetics; Methods; Optical Rotation; Pipecolic Acids; Stereoisomerism; Sulfonamides; Thrombin | 1981 |
Argatroban and inhibition of the vasomotor actions of thrombin.
Topics: Animals; Antithrombins; Arginine; Dogs; Endothelium, Vascular; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Pipecolic Acids; Sulfonamides; Thrombin; Vasoconstriction | 1993 |
Heparin inhibits endothelin-1 and proto-oncogene c-fos gene expression in cultured bovine endothelial cells.
Topics: Alkaloids; Animals; Antithrombins; Arginine; Blotting, Northern; Cattle; Cells, Cultured; DNA Probes; Endothelin-1; Endothelins; Endothelium, Vascular; Gene Expression; Genes, fos; Heparin; Pipecolic Acids; Protein Kinase C; Protein Precursors; RNA, Messenger; Staurosporine; Sulfonamides; Thrombin | 1993 |
Characterization of platelet activity in neuroblastoma.
Topics: Antithrombins; Arginine; Child, Preschool; Female; Humans; Iloprost; Infant; Infant, Newborn; Kidney Neoplasms; Male; Neuroblastoma; Pheochromocytoma; Pipecolic Acids; Platelet Aggregation; Sulfonamides; Tissue Extracts; Wilms Tumor | 1994 |
Direct inhibition of protein Ca by site directed thrombin inhibitors: implications in anticoagulant and thrombolytic therapy.
Topics: Antifibrinolytic Agents; Antithrombin III; Antithrombins; Aprotinin; Arginine; Binding Sites; Boron Compounds; Enzyme Activation; Fibrinolysis; Heparin; Hirudins; Humans; Oligopeptides; Peptide Fragments; Pipecolic Acids; Protein C; Recombinant Proteins; Sulfonamides; Thrombin | 1995 |
[Effect of argatroban on flap survival length].
Topics: Animals; Antithrombins; Arginine; Female; Graft Survival; Laser-Doppler Flowmetry; Microcirculation; Pipecolic Acids; Rats; Rats, Wistar; Skin; Skin Transplantation; Sulfonamides; Surgical Flaps | 1995 |
Inhibitory effect of clopidogrel, vapiprost and argatroban on the middle cerebral artery thrombosis in the rat.
Topics: Animals; Arginine; Biphenyl Compounds; Cerebral Arteries; Cerebrovascular Circulation; Clopidogrel; Fibrinolytic Agents; Heptanoic Acids; Intracranial Embolism and Thrombosis; Male; Photic Stimulation; Pipecolic Acids; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Receptors, Thromboxane; Regional Blood Flow; Sulfonamides; Thromboxane A2; Ticlopidine | 1995 |
Comparative studies on the anticoagulant and protease generation inhibitory actions of newly developed site-directed thrombin inhibitory drugs. Efegatran, argatroban, hirulog, and hirudin.
Topics: Amino Acid Sequence; Anticoagulants; Antithrombins; Arginine; Endopeptidases; Feedback; Hirudins; Humans; Molecular Sequence Data; Oligopeptides; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides | 1995 |
[An experimental study of arterial graft implantation--the effects of an anti-thrombin agent, argatroban, and an anti-platelet agent, clopidogrel (SR 25990 C) on the inner capsule].
Topics: Angioscopy; Animals; Antithrombins; Aorta, Abdominal; Arginine; Blood Coagulation; Blood Vessel Prosthesis; Clopidogrel; Dogs; Fibrinolysis; Graft Occlusion, Vascular; Pipecolic Acids; Platelet Aggregation Inhibitors; Sulfonamides; Ticlopidine | 1994 |
[Evaluation of serum thrombomodulin in patients with interstitial pneumonia].
Topics: Adult; Aged; Antithrombins; Arginine; Biomarkers; Blood Coagulation; Endothelium, Vascular; Fibrinolysis; Hemostasis; Humans; Lung Diseases, Interstitial; Male; Middle Aged; Pipecolic Acids; Prospective Studies; Sulfonamides; Thrombomodulin | 1994 |
Enhancement of thrombolytic efficacy of tissue-type plasminogen activator by adjuvants in the guinea pig thrombosis model.
Topics: Adjuvants, Pharmaceutic; Animals; Antithrombins; Arginine; Biphenyl Compounds; Disease Models, Animal; Drug Therapy, Combination; Endothelium, Vascular; Femoral Artery; Fibrinolytic Agents; Guinea Pigs; Heptanoic Acids; Indoles; Leukotriene Antagonists; Male; Microscopy, Electron, Scanning; Neutrophils; Pipecolic Acids; Platelet Aggregation Inhibitors; Receptors, Thromboxane; Recombinant Proteins; Sulfonamides; Thrombolytic Therapy; Thrombosis; Tissue Plasminogen Activator | 1994 |
Effects of the synthetic thrombin inhibitor argatroban on fibrin- or clot-incorporated thrombin: comparison with heparin and recombinant Hirudin.
Topics: Antithrombins; Arginine; Blood Coagulation; Dipeptides; Dose-Response Relationship, Drug; Fibrin; Heparin; Hirudins; Humans; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombin | 1994 |
Antithrombotic actions of argatroban in rat models of venous, 'mixed' and arterial thrombosis, and its effects on the tail transection bleeding time.
Topics: Animals; Arginine; Arteriovenous Shunt, Surgical; Bleeding Time; Carotid Arteries; Electric Stimulation; Fibrinolytic Agents; Heparin; Male; Pipecolic Acids; Rats; Sulfonamides; Tail; Thrombophlebitis; Thrombosis | 1994 |
Increased tissue factor pathway inhibitor levels in uremic patients on regular hemodialysis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arginine; Benzamidines; Blood Coagulation Factors; Blood Urea Nitrogen; Creatinine; Female; Guanidines; Heparin; Heparin, Low-Molecular-Weight; Humans; Lipids; Lipoproteins; Male; Middle Aged; Pipecolic Acids; Renal Dialysis; Sulfonamides; Uremia | 1994 |
Inhibition of factor Xa-induced platelet aggregation by a selective thrombin inhibitor, argatroban.
Topics: Animals; Antithrombins; Arginine; Factor Xa Inhibitors; Pipecolic Acids; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Sulfonamides | 1994 |
Accelerated thrombin generation during anticoagulation in patients with unstable angina pectoris.
Topics: Angina, Unstable; Antithrombin III; Antithrombins; Arginine; Humans; Infusions, Intravenous; Peptide Hydrolases; Pipecolic Acids; Sulfonamides; Thrombin; Time Factors | 1994 |
Involvement of the "tethered ligand" receptor in thrombin-induced endothelium-mediated relaxations.
Topics: Amino Acid Sequence; Animals; Antithrombins; Arginine; Coronary Vessels; Dogs; Endothelium, Vascular; Humans; In Vitro Techniques; Indomethacin; Molecular Sequence Data; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroarginine; Oligopeptides; Peptide Fragments; Peptides; Pipecolic Acids; Receptors, Thrombin; Saphenous Vein; Sulfonamides; Swine; Thrombin; Vasodilation | 1993 |
Separation of 21-(R)- and 21-(S)-argatroban: solubility and activity of the individual diastereoisomers.
Topics: Animals; Antithrombins; Arginine; Blood Coagulation; Cattle; Chromatography, High Pressure Liquid; Humans; Isomerism; Pipecolic Acids; Solubility; Sulfonamides | 1993 |
Effects of thrombin receptor activating peptide on phosphoinositide hydrolysis and protein kinase C activation in cultured rat aortic smooth muscle cells: evidence for "tethered-ligand" activation of smooth muscle cell thrombin receptors.
Topics: Animals; Aorta; Arginine; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Muscle, Smooth; Peptide Fragments; Peptides; Phosphatidylinositols; Pipecolic Acids; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Thrombin; Sulfonamides; Thrombin | 1993 |
Synthetic selective inhibitors of thrombin.
Topics: Amino Acid Sequence; Animals; Antithrombin III; Antithrombins; Arginine; Cattle; Dansyl Compounds; Fibrin; Fibrinogen; Heparin; Humans; Infant, Newborn; Kinetics; Molecular Sequence Data; Molecular Structure; Oligopeptides; Pipecolic Acids; Structure-Activity Relationship; Substrate Specificity; Sulfonamides; Thrombin | 1993 |
In vitro and in vivo characterization of a neutral boron-containing thrombin inhibitor.
Topics: Animals; Antithrombins; Arginine; Blood Coagulation Tests; Boron; Bridged Bicyclo Compounds; Cells, Cultured; Dipeptides; Hirudins; Humans; Kinetics; Male; Oligopeptides; Pipecolic Acids; Piperidines; Platelet Activation; Platelet Aggregation; Rats; Rats, Wistar; Sulfonamides; Thrombin | 1993 |
Thrombin inhibitors in unstable angina: rebound or continuation of angina after argatroban withdrawal?
Topics: Angina, Unstable; Antithrombin III; Antithrombins; Arginine; Humans; Pipecolic Acids; Recurrence; Sulfonamides; Thrombin | 1993 |
The antithrombotic effect of low molecular weight synthetic thrombin inhibitors, argatroban and PPACK, on He-Ne laser-induced thrombosis in rat mesenteric microvessels.
Topics: Amino Acid Chloromethyl Ketones; Animals; Antithrombins; Arginine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Male; Mesentery; Microcirculation; Pipecolic Acids; Platelet Aggregation; Rats; Rats, Wistar; Sulfonamides; Thrombin; Thrombosis | 1993 |
Effect of argatroban on microthrombi formation and brain damage in the rat middle cerebral artery thrombosis model.
Topics: Animals; Antithrombins; Arginine; Arterial Occlusive Diseases; Cerebral Arteries; Disease Models, Animal; Intracranial Embolism and Thrombosis; Male; Pipecolic Acids; Rats; Rats, Wistar; Sulfonamides; Thrombin; Time Factors | 1995 |
Effective anticoagulation by argatroban during immunoadsorption therapy for malignant rheumatoid arthritis with a high polymorphonuclear leukocyte elastase level.
Topics: Antithrombins; Arginine; Arthritis, Rheumatoid; Humans; Immunosorbents; Leukocyte Elastase; Male; Middle Aged; Neutrophils; Pancreatic Elastase; Pipecolic Acids; Sulfonamides | 1995 |
The combination of thrombin inhibitor and thromboxane synthase inhibitor on experimental thrombosis and bleeding.
Topics: Animals; Antithrombins; Arginine; Bleeding Time; Drug Synergism; Drug Therapy, Combination; Infusions, Intravenous; Male; Methacrylates; Pipecolic Acids; Rabbits; Sulfonamides; Thrombin; Thrombosis; Thromboxane-A Synthase | 1995 |
Antithrombotic effects of TAK-029, a novel GPIIb/IIIa antagonist, in guinea pigs: comparative studies with ticlopidine, clopidogrel, aspirin, prostaglandin E1 and argatroban.
Topics: Alprostadil; Animals; Arginine; Aspirin; Clopidogrel; Dogs; Fibrinolytic Agents; Guanidines; Guinea Pigs; Humans; Macaca fascicularis; Male; Pipecolic Acids; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Pyrazines; Sulfonamides; Ticlopidine | 1996 |
[Change in argatroban concentration within the vessel wall after local administration using hydrogel-coated balloon catheter].
Topics: Angioplasty, Balloon, Coronary; Animals; Antithrombins; Arginine; Catheterization; Coronary Vessels; Hydrogel, Polyethylene Glycol Dimethacrylate; Pipecolic Acids; Polyethylene Glycols; Rabbits; Sulfonamides | 1996 |
Inhibition by Argatroban, a specific thrombin inhibitor, of platelet activation by fibrin clot-associated thrombin.
Topics: Animals; Antithrombin III; Antithrombins; Arginine; Fibrin; Fibrinolytic Agents; Heparin; Hirudins; Pipecolic Acids; Platelet Activation; Platelet Aggregation Inhibitors; Rabbits; Recombinant Proteins; Sulfonamides; Thrombosis | 1996 |
[Familial Binswanger-type encephalopathy with Sneddon syndrome].
Topics: Adult; Antithrombin III; Antithrombins; Arginine; Cerebral Infarction; Dementia; Factor V; Female; Fibrinogen; Humans; Male; Migraine Disorders; Peptide Hydrolases; Pipecolic Acids; Sneddon Syndrome; Sulfonamides; Syndrome | 1996 |
Potent thrombin inhibitors that probe the S1 subsite: tripeptide transition state analogues based on a heterocycle-activated carbonyl group.
Topics: Amino Acid Sequence; Animals; Arginine; Binding Sites; Cattle; Crystallography, X-Ray; Guanidines; Humans; Molecular Sequence Data; Molecular Structure; Oligopeptides; Peptides; Pipecolic Acids; Protein Binding; Serine Proteinase Inhibitors; Sulfonamides; Thiazoles; Thrombin; Trypsin Inhibitors | 1996 |
Antithrombotic actions of the thrombin inhibitor, argatroban, in a canine model of coronary cyclic flow: comparison with heparin.
Topics: Angina, Unstable; Animals; Antithrombins; Arginine; Coronary Vessels; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Heparin; Male; Pipecolic Acids; Sulfonamides; Thrombin Time; Time Factors | 1996 |
Crystal structure of two new bifunctional nonsubstrate type thrombin inhibitors complexed with human alpha-thrombin.
Topics: Amino Acid Sequence; Antithrombins; Arginine; Binding Sites; Coagulants; Crystallization; Crystallography, X-Ray; Fibrinogen; Hirudins; Humans; Hydrogen Bonding; Hydrolysis; Naphthalenesulfonates; Peptide Fragments; Peptides; Pipecolic Acids; Protein Structure, Secondary; Serine Proteinase Inhibitors; Sulfonamides; Thrombin | 1996 |
Effects of a thrombin inhibitor, argatroban, on ischemic brain damage in the rat distal middle cerebral artery occlusion model.
Topics: Animals; Antithrombins; Arginine; Brain Ischemia; Cerebral Arteries; Disease Models, Animal; Male; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Sulfonamides | 1996 |
Report of successful use of argatroban as an alternative anticoagulant during coronary stent implantation in a patient with heparin-induced thrombocytopenia and thrombosis syndrome.
Topics: Aged; Angioplasty, Balloon, Coronary; Arginine; Coronary Angiography; Coronary Disease; Female; Heparin; Humans; Myocardial Infarction; Pipecolic Acids; Platelet Aggregation Inhibitors; Stents; Sulfonamides; Syndrome; Thrombocytopenia; Thrombosis | 1996 |
Functionality map analysis of the active site cleft of human thrombin.
Topics: Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Arginine; Binding Sites; Dipeptides; Humans; Models, Molecular; Molecular Probes; Molecular Sequence Data; Molecular Structure; Pipecolic Acids; Piperidines; Protein Conformation; Serine Proteinase Inhibitors; Software; Sulfonamides; Thrombin | 1996 |
Low-molecular-weight heparin (fragmin) and thrombin active-site inhibitor (argatroban) compared in experimental arterial and venous thrombosis and bleeding time.
Topics: Animals; Antithrombins; Arginine; Bleeding Time; Dalteparin; Dose-Response Relationship, Drug; Fibrinolytic Agents; Male; Partial Thromboplastin Time; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Sulfonamides; Thrombosis | 1996 |
Antithrombotic activity of argatroban in experimental thrombosis in the rabbit.
Topics: Animals; Antithrombins; Arginine; Disease Models, Animal; Dose-Response Relationship, Drug; Femoral Artery; Infusions, Intravenous; Pipecolic Acids; Rabbits; Sulfonamides; Thrombosis | 1996 |
Effects of inogatran, a new low-molecular-weight thrombin inhibitor, in rat models of venous and arterial thrombosis, thrombolysis and bleeding time.
Topics: Animals; Antithrombins; Arginine; Aspirin; Bleeding Time; Disease Models, Animal; Fibrinolytic Agents; Glycine; Heparin; Male; Molecular Weight; Pipecolic Acids; Piperidines; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Sulfonamides; Thrombolytic Therapy; Thrombophlebitis; Thrombosis | 1996 |
Effect of argatroban on the formation of artificial thrombus on dogs.
Topics: Animals; Arginine; Dogs; Male; Osmolar Concentration; Pipecolic Acids; Platelet Aggregation Inhibitors; Sulfonamides; Thrombosis; Ticlopidine | 1995 |
Comparative anticoagulant effects of various thrombin inhibitors, as determined in the ecarin clotting time method.
Topics: Antithrombins; Arginine; Blood Coagulation Tests; Boron Compounds; Dose-Response Relationship, Drug; Endopeptidases; Enzyme Precursors; Fibrinolytic Agents; Heparin; Hirudins; Humans; Oligopeptides; Partial Thromboplastin Time; Pipecolic Acids; Prothrombin; Sulfonamides; Thrombin | 1996 |
Induction of thrombolysis and prevention of thrombus formation by local drug delivery with a double-occlusion balloon catheter.
Topics: Angioscopy; Animals; Anticoagulants; Antithrombins; Arginine; Catheterization; Coronary Angiography; Coronary Thrombosis; Coronary Vessels; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Heparin; Injections, Intralesional; Pipecolic Acids; Plasminogen Activators; Sulfonamides; Thrombolytic Therapy; Treatment Outcome | 1996 |
Local treatment with an antithrombotic drug reduces thrombus size in coronary and peripheral thrombosed arteries.
Topics: Angioscopy; Animals; Antithrombins; Arginine; Batroxobin; Coronary Angiography; Coronary Thrombosis; Coronary Vessels; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Fibrinolytic Agents; Heparin; Infusions, Intravenous; Injections, Intralesional; Pipecolic Acids; Reference Values; Sulfonamides; Treatment Outcome | 1996 |
The in vitro effects of chylomicron remnant and very low density lipoprotein remnant on platelet aggregation in blood obtained from healthy persons.
Topics: Antithrombins; Arginine; Chylomicrons; Collagen; Humans; In Vitro Techniques; Lipoproteins, VLDL; Pipecolic Acids; Platelet Activation; Platelet Aggregation; Reference Values; Sulfonamides | 1996 |
[Argatroban, a selective thrombin inhibitor, for anticoagulant therapy during and following vascular surgery].
Topics: Aged; Aged, 80 and over; Anticoagulants; Antithrombins; Aortic Aneurysm, Abdominal; Arginine; Arteriosclerosis; Blood Vessel Prosthesis; Female; Humans; Male; Middle Aged; Pipecolic Acids; Sulfonamides; Vascular Surgical Procedures | 1996 |
New model for in vivo studies of pharmacological interventions with endogenous fibrinolysis: effects of thrombin inhibitors.
Topics: Animals; Antithrombins; Arginine; Batroxobin; Boron Compounds; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrinolysis; Injections, Intravenous; Male; Oligopeptides; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Sulfonamides; Thrombin | 1996 |
Local delivery of antithrombotic drug prevents restenosis after balloon angioplasty in atherosclerotic rabbit artery.
Topics: Angiography; Angioplasty, Balloon, Coronary; Angioscopy; Animals; Antithrombins; Arginine; Arteriosclerosis; Batroxobin; Constriction, Pathologic; Fibrinolytic Agents; Fluorescein-5-isothiocyanate; Heparin, Low-Molecular-Weight; Iliac Artery; Male; Microscopy, Confocal; Pipecolic Acids; Rabbits; Sulfonamides; Thrombosis | 1996 |
[A case of Fournier's gangrene with healing accelerated by argatroban].
Topics: Anti-Bacterial Agents; Antithrombins; Arginine; Combined Modality Therapy; Debridement; Diabetes Complications; Fournier Gangrene; Genital Diseases, Male; Humans; Male; Middle Aged; Pipecolic Acids; Scrotum; Sulfonamides; Tomography, X-Ray Computed | 1996 |
Thrombin and trypsin induce granulocyte-macrophage colony-stimulating factor and interleukin-6 gene expression in cultured normal human keratinocytes.
Topics: Aprotinin; Arginine; Base Sequence; Cadherins; Calcium; Cells, Cultured; DNA Primers; Gene Expression; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Integrin beta1; Interleukin-6; Keratinocytes; Molecular Sequence Data; Monensin; Oligopeptides; Peptide Fragments; Pipecolic Acids; Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Thrombin; Trypsin; Trypsin Inhibitors | 1997 |
Novastan anticoagulation during renal stent implant in a patient with heparin-induced thrombocytopenia.
Topics: Aged; Anticoagulants; Arginine; Coronary Artery Bypass; Heparin; Humans; Intraoperative Complications; Kidney; Male; Pipecolic Acids; Stents; Sulfonamides; Thrombocytopenia | 1997 |
Anti-thrombogenic effects of 2-hydroxyethylmethacrylate-styrene block copolymer and argatroban in synthetic small-caliber vascular grafts in a rabbit inferior vena cava model.
Topics: Anastomosis, Surgical; Animals; Anticoagulants; Antithrombins; Arginine; Blood Vessel Prosthesis; Heparin; Male; Methacrylates; Microscopy, Electron; Microscopy, Electron, Scanning; Pipecolic Acids; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Polystyrenes; Polyurethanes; Prosthesis Design; Proteins; Rabbits; Regional Blood Flow; Sulfonamides; Surface Properties; Ultrasonography; Vascular Patency; Vena Cava, Inferior | 1997 |
Use of thrombin inhibitors ex vivo allows critical care clinical chemistry and hematology testing on common specimens.
Topics: Amino Acid Chloromethyl Ketones; Antithrombins; Arginine; Blood Chemical Analysis; Blood Preservation; Blood Specimen Collection; Critical Care; Humans; Pipecolic Acids; Sulfonamides | 1997 |
Thrombin receptor-dependent prostaglandin E2 synthesis in hamster fibroblasts: synergistic interactions with interleukin-1beta.
Topics: Animals; Antithrombins; Arginine; Cricetinae; Cyclooxygenase 2; Dinoprostone; Drug Synergism; Fibroblasts; Hydrolysis; Interleukin-1; Isoenzymes; Peptide Fragments; Phosphatidylinositols; Pipecolic Acids; Prostaglandin-Endoperoxide Synthases; Receptors, Thrombin; Sulfonamides; Thrombin | 1997 |
Effects of locally administration of argatroban using a hydrogel-coated balloon catheter on intimal thickening induced by balloon injury.
Topics: Angioplasty, Balloon, Coronary; Animals; Antithrombins; Arginine; Blood Platelets; Carotid Artery Injuries; Carotid Artery, Common; Drug Delivery Systems; Hydrogel, Polyethylene Glycol Dimethacrylate; Hyperplasia; Pipecolic Acids; Polyethylene Glycols; Rabbits; Sulfonamides; Tunica Intima | 1997 |
Binding affinities for sulfonamide inhibitors with human thrombin using Monte Carlo simulations with a linear response method.
Topics: Antithrombins; Arginine; Binding Sites; Humans; Hydrogen Bonding; Monte Carlo Method; Pipecolic Acids; Sulfonamides; Thermodynamics; Thrombin | 1997 |
Comparative intravenous antithrombotic actions of heparin and site directed thrombin inhibitors in a jugular vein clamping model.
Topics: Animals; Antithrombins; Arginine; Constriction; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fibrinolytic Agents; Heparin; Hirudins; Injections, Intravenous; Jugular Veins; Male; Models, Cardiovascular; Peptide Fragments; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sulfonamides | 1996 |
Adjuvant effect of argatroban on staphylokinase induced thrombolysis of platelet rich thrombi in rat mesenteric venules in vivo.
Topics: Animals; Antithrombins; Arginine; Blood Platelets; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Fibrinolysis; Fibrinolytic Agents; Image Processing, Computer-Assisted; Male; Metalloendopeptidases; Microscopy, Electron; Pipecolic Acids; Rats; Rats, Wistar; Recombinant Proteins; Sulfonamides; Thrombosis | 1997 |
In vivo evaluation of DX-9065a, a synthetic factor Xa inhibitor, in experimental vein graft.
Topics: Animals; Anticoagulants; Antithrombins; Arginine; Blood Vessel Prosthesis; Disease Models, Animal; Factor Xa Inhibitors; Graft Occlusion, Vascular; Heparin; Male; Microscopy, Electron, Scanning; Naphthalenes; Pipecolic Acids; Propionates; Rabbits; Sulfonamides; Thrombosis | 1996 |
A comparison of heuristic search algorithms for molecular docking.
Topics: Algorithms; Arginine; Azepines; Binding Sites; Computer Simulation; Dipeptides; HIV Protease; Ligands; Macromolecular Substances; Methotrexate; Models, Molecular; Neuraminidase; Pipecolic Acids; Piperidines; Protein Binding; Software Design; Structure-Activity Relationship; Sulfonamides; Tetrahydrofolate Dehydrogenase; Thermodynamics; Thrombin | 1997 |
Factor X values as a means to assess the extent of oral anticoagulation in patients receiving antithrombin drugs.
Topics: Administration, Oral; Angioplasty, Balloon, Coronary; Anticoagulants; Antithrombins; Arginine; Blood Coagulation Factors; Blood Coagulation Tests; Drug Monitoring; Drug Therapy, Combination; Factor X; False Positive Reactions; Female; Heparin; Humans; Indicators and Reagents; Male; Pipecolic Acids; Prothrombin Time; Reference Values; Reproducibility of Results; Sulfonamides; Thrombocytopenia; Thrombosis; Warfarin | 1997 |
Inhibition of collagen-induced platelet aggregation by argatroban in patients with acute cerebral infarction.
Topics: Acute Disease; Aged; Aged, 80 and over; Arginine; Cerebral Infarction; Collagen; Dose-Response Relationship, Drug; Female; Humans; Male; Pipecolic Acids; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Sensitivity and Specificity; Sulfonamides; Thrombin; Time Factors | 1997 |
Effects of locally administered argatroban on restenosis after balloon angioplasty: experimental and clinical study.
Topics: Angioplasty, Balloon; Animals; Antithrombins; Arginine; Cell Division; Coronary Disease; Humans; Muscle, Smooth, Vascular; Pipecolic Acids; Platelet Activation; Rabbits; Sulfonamides | 1997 |
Inhibition of thrombin generation in plasma by inhibitors of factor Xa.
Topics: Animals; Anticoagulants; Arginine; Arthropod Proteins; Cattle; Dipeptides; Factor Xa; Factor Xa Inhibitors; Fibrinolytic Agents; Hirudins; Humans; Intercellular Signaling Peptides and Proteins; Kinetics; Molecular Structure; Naphthalenes; Partial Thromboplastin Time; Peptides; Pipecolic Acids; Piperidines; Propionates; Rabbits; Recombinant Proteins; Serine Proteinase Inhibitors; Sulfonamides; Sulfones; Thrombin; Thromboplastin | 1997 |
The importance of enzyme inhibition kinetics for the effect of thrombin inhibitors in a rat model of arterial thrombosis.
Topics: Amino Acid Chloromethyl Ketones; Animals; Anticoagulants; Arginine; Azetidines; Benzylamines; Carotid Artery Thrombosis; Dose-Response Relationship, Drug; Fibrinolytic Agents; Glycine; Hemodynamics; Heparin; Hirudin Therapy; Hirudins; Kinetics; Male; Oligopeptides; Partial Thromboplastin Time; Peptide Fragments; Pipecolic Acids; Piperidines; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sulfonamides; Thrombin; Thrombin Time | 1997 |
Antithrombotic and hemorrhagic effects of DX-9065a, a direct and selective factor Xa inhibitor: comparison with a direct thrombin inhibitor and antithrombin III-dependent anticoagulants.
Topics: Animals; Anticoagulants; Antithrombin III; Arginine; Bleeding Time; Blood Coagulation; Disease Models, Animal; Factor Xa Inhibitors; Hemorrhage; Heparin, Low-Molecular-Weight; Male; Naphthalenes; Peptide Hydrolases; Pipecolic Acids; Propionates; Rats; Rats, Wistar; Sulfonamides; Thrombin; Thrombosis | 1997 |
The first report of successful carotid stent implant using argatroban anticoagulation in a patient with heparin-induced thrombocytopenia and thrombosis syndrome: a case report.
Topics: Aged; Anticoagulants; Antithrombins; Arginine; Carotid Arteries; Carotid Stenosis; Catheterization; Cerebrovascular Disorders; Femoral Artery; Follow-Up Studies; Heparin; Humans; Male; Paresis; Pipecolic Acids; Platelet Aggregation Inhibitors; Recurrence; Stents; Sulfonamides; Syndrome; Thrombocytopenia; Thrombosis | 1998 |
Ecarin Clotting Time: a predictive coagulation assay for the antithrombotic activity of argatroban in the rat.
Topics: Animals; Antithrombins; Arginine; Arteriovenous Shunt, Surgical; Blood Coagulation Tests; Disease Models, Animal; Male; Pipecolic Acids; Rats; Rats, Inbred Strains; Reference Values; Sulfonamides; Thrombophlebitis; Thromboplastin; Thrombosis; Treatment Outcome | 1998 |
YM-60828, a novel factor Xa inhibitor: separation of its antithrombotic effects from its prolongation of bleeding time.
Topics: Animals; Anticoagulants; Antithrombins; Arginine; Bleeding Time; Dalteparin; Factor Xa Inhibitors; Fibrinolytic Agents; Heparin; Male; Naphthalenes; Pipecolic Acids; Piperidines; Rats; Rats, Sprague-Dawley; Sulfonamides | 1997 |
Antithrombotic effects of YM-60828, a newly synthesized factor Xa inhibitor, in rat thrombosis models and its effects on bleeding time.
Topics: Animals; Anticoagulants; Arginine; Arteriovenous Shunt, Surgical; Bleeding Time; Blood Proteins; Dalteparin; Factor Xa Inhibitors; Fibrinolytic Agents; Heparin; In Vitro Techniques; Male; Naphthalenes; Partial Thromboplastin Time; Pipecolic Acids; Piperidines; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Sulfonamides; Thrombophlebitis; Thrombosis | 1998 |
Synthesis of monomeric and polymeric conjugates carrying a thrombin inhibitor through an ester bond.
Topics: Antithrombins; Arginine; Blood Coagulation; Esters; Humans; Pipecolic Acids; Polymers; Sulfonamides | 1998 |
Comparative studies of an orally-active factor Xa inhibitor, YM-60828, with other antithrombotic agents in a rat model of arterial thrombosis.
Topics: Administration, Oral; Animals; Anticoagulants; Antithrombin III; Arginine; Carotid Artery Thrombosis; Disease Models, Animal; Factor Xa Inhibitors; Heparin; Infusions, Intravenous; Naphthalenes; Pipecolic Acids; Piperidines; Rats; Sulfonamides | 1998 |
BCH-2763, a novel potent parenteral thrombin inhibitor, is an effective antithrombotic agent in rodent models of arterial and venous thrombosis--comparisons with heparin, r-hirudin, hirulog, inogatran and argatroban.
Topics: Animals; Anticoagulants; Arginine; Arteries; Glycine; Heparin; Hirudins; Humans; Infusions, Intravenous; Oligopeptides; Peptide Fragments; Pipecolic Acids; Piperidines; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sulfonamides; Thrombin; Thrombosis; Veins | 1998 |
Study of the pharmacological effect of the bile salt, sodium scymnol sulfate, from Rhizoprionodon acutus. II. Prophylactic effect of scymnol on lesion development in a rat peripheral arterial occlusion model.
Topics: Animals; Antithrombins; Arginine; Arterial Occlusive Diseases; Blood Coagulation; Cholestanols; Elasmobranchii; Fibrinolysis; Male; Pipecolic Acids; Rats; Rats, Wistar; Sulfonamides; Ticlopidine | 1998 |
Effect of a synthetic factor Xa inhibitor, YM-60828, on blood vessel patency in combination with a thrombolytic agent and on blood loss from the operation site in a rat model of arterial thrombosis.
Topics: Animals; Anticoagulants; Arginine; Blood Loss, Surgical; Carotid Arteries; Carotid Artery Thrombosis; Drug Evaluation, Preclinical; Hemorrhage; Heparin; Male; Naphthalenes; Pipecolic Acids; Piperidines; Rats; Recurrence; Reperfusion; Serine Proteinase Inhibitors; Sulfonamides; Thrombolytic Therapy; Time Factors; Tissue Plasminogen Activator | 1998 |
Effective anticoagulation by argatroban during coronary stent implantation in a patient with heparin-induced thrombocytopenia.
Topics: Anticoagulants; Antithrombins; Arginine; Coronary Disease; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Stents; Sulfonamides; Thrombocytopenia | 1997 |
Effects of dermatan sulfate, a heparin cofactor II mediated thrombin inhibitor, on the endotoxin-induced disseminated intravascular coagulation model in the rat: comparison with low-molecular weight heparin, nafamostat mesilate and argathroban.
Topics: Animals; Arginine; Benzamidines; Dermatan Sulfate; Disease Models, Animal; Disseminated Intravascular Coagulation; Endotoxins; Guanidines; Heparin; Heparin Cofactor II; Male; Molecular Weight; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Sulfonamides | 1998 |
Suppression of prostanoid formation and regulation of peripheral circulation after surgery using thrombin inhibitor (MD805).
Topics: Animals; Antithrombin III; Antithrombins; Arginine; Cardiac Output; Dogs; Hemodynamics; Peptide Hydrolases; Pipecolic Acids; Prostaglandins; Stress, Physiological; Sulfonamides; Surgical Procedures, Operative; Thromboxane B2 | 1998 |
No effect of clot age or thrombolysis on argatroban's inhibition of thrombin.
Topics: Arginine; Blood Coagulation; Blood Coagulation Tests; Fibrin; Fibrinolysis; Humans; Models, Biological; Perfusion; Pipecolic Acids; Streptokinase; Sulfonamides; Thrombin; Time Factors; Tissue Plasminogen Activator | 1998 |
Inhibitory effect of argatroban on thrombin-induced MAP kinase activation.
Topics: Animals; Antithrombins; Arginine; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Drug Antagonism; Enzyme Activation; Muscle, Smooth, Vascular; Pipecolic Acids; Rats; Sulfonamides; Thrombin | 1998 |
Antithrombotic activity of a monoclonal antibody inducing the substrate form of plasminogen activator inhibitor type 1 in rat models of venous and arterial thrombosis.
Topics: Animals; Antibodies, Monoclonal; Anticoagulants; Arginine; Bleeding Time; Cross Reactions; Fibrinolytic Agents; Heparin; Humans; Male; Pipecolic Acids; Plasminogen Activator Inhibitor 1; Platelet Aggregation Inhibitors; Rats; Sulfonamides; Thrombosis; Venous Thrombosis | 1998 |
Platelet aggregation induced in vitro by rabbit plasma clot-associated thrombin, and its inhibition by thrombin inhibitors.
Topics: Animals; Antithrombin III; Arginine; Blood Coagulation; Blood Platelets; Heparin; Hirudins; Humans; Male; Microscopy, Electron, Scanning; Pipecolic Acids; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Recombinant Proteins; Sulfonamides; Thrombin; Thromboplastin | 1998 |
Effects of recombinant human soluble thrombomodulin (rhs-TM) on clot-induced coagulation in human plasma.
Topics: Antithrombins; Arginine; Blood Coagulation; Carboxypeptidase B2; Carboxypeptidases; Dalteparin; Dose-Response Relationship, Drug; Enzyme Activation; Fibrinopeptide A; Heparin; Humans; Pipecolic Acids; Protein C; Recombinant Fusion Proteins; Sulfonamides; Thrombelastography; Thrombin; Thrombomodulin | 1998 |
Synergistic antithrombotic effects of argatroban and ticlopidine in the rat venous thrombosis model.
Topics: Animals; Anticoagulants; Antithrombins; Arginine; Drug Synergism; Male; Pipecolic Acids; Rats; Rats, Wistar; Sulfonamides; Ticlopidine; Venous Thrombosis | 1998 |
The mechanism of binding of low-molecular-weight active site inhibitors to human alpha-thrombin.
Topics: Antithrombins; Area Under Curve; Arginine; Azetidines; Benzylamines; Binding Sites; Dipeptides; Fluorescence; Glycine; Humans; Kinetics; Molecular Weight; Pipecolic Acids; Piperidines; Spectrometry, Fluorescence; Spectrophotometry; Sulfonamides; Thrombin | 1998 |
Effects of antithrombin on Binswanger's disease with antiphospholipid antibody syndrome.
Topics: Antiphospholipid Syndrome; Antithrombin III; Antithrombins; Arginine; Basal Ganglia Diseases; Dementia, Multi-Infarct; Female; Fibrinogen; Hemostasis; Humans; Magnetic Resonance Imaging; Middle Aged; Peptide Hydrolases; Pipecolic Acids; Sulfonamides | 1999 |
The International Normalized Ratio during concurrent warfarin and argatroban anticoagulation: differential contributions of each agent and effects of the choice of thromboplastin used.
Topics: Anticoagulants; Arginine; Humans; International Normalized Ratio; Pipecolic Acids; Prothrombin Time; Sulfonamides; Thromboplastin; Warfarin | 1999 |
Pharmacological effects of a novel recombinant hirudin, CX-397, in vivo and in vitro: comparison with recombinant hirudin variant-1, heparin, and argatroban.
Topics: Amino Acid Sequence; Animals; Arginine; Arterial Occlusive Diseases; Arteriovenous Shunt, Surgical; Chlorides; Drug Evaluation, Preclinical; Ferric Compounds; Fibrinolytic Agents; Glass; Hemorrhage; Heparin; Hirudin Therapy; Hirudins; Molecular Sequence Data; Pipecolic Acids; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Serine Proteinase Inhibitors; Sulfonamides; Thrombin; Thrombosis; Vena Cava, Inferior; Venous Thrombosis | 1999 |
Local drug delivery of argatroban from a polymeric-metallic composite stent reduces platelet deposition in a swine coronary model.
Topics: Animals; Antithrombins; Arginine; Blood Platelets; Coronary Thrombosis; Coronary Vessels; Indium Radioisotopes; Metals; Pipecolic Acids; Polymers; Random Allocation; Stents; Sulfonamides; Swine | 1999 |
Argatroban as a potential anticoagulant in cardiopulmonary bypass-studies in a dog model.
Topics: Animals; Anticoagulants; Arginine; Blood Coagulation; Cardiopulmonary Bypass; Coated Materials, Biocompatible; Dogs; Fibrinolysis; Hematocrit; Heparin; Pipecolic Acids; Platelet Count; Sulfonamides | 1999 |
Use of argatroban during percutaneous coronary interventions in patients with heparin-induced thrombocytopenia.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Arginine; Coronary Disease; Drug Evaluation; Heparin; Humans; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Thrombosis | 1999 |
Coagulation laboratory testing in patients treated with argatroban.
Topics: Antithrombins; Arginine; Biological Assay; Blood Coagulation; Blood Coagulation Tests; Drug Monitoring; Humans; Partial Thromboplastin Time; Pipecolic Acids; Prothrombin Time; Reproducibility of Results; Sulfonamides | 1999 |
Clinical experience with combined treatment of thrombin inhibitors and GPIIb/IIIa inhibitors in patients with HIT.
Topics: Abciximab; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Anticoagulants; Antithrombins; Arginine; Blood Platelets; Drug Therapy, Combination; Female; Heparin; Hirudin Therapy; Humans; Immunoglobulin Fab Fragments; Male; Pipecolic Acids; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Sulfonamides; Thrombocytopenia; Tirofiban; Tyrosine | 1999 |
Platelet activation with unfractionated heparin at therapeutic concentrations and comparison with low-molecular-weight heparin and with a direct thrombin inhibitor.
Topics: Angina, Unstable; Anticoagulants; Antithrombins; Arginine; Heparin; Heparin, Low-Molecular-Weight; Hirudins; Humans; Pipecolic Acids; Platelet Activation; Platelet Aggregation Inhibitors; Sulfonamides; Thrombolytic Therapy | 1999 |
Experimental study of ectopic-free tissue transfer of rabbit epigastric flap using small-caliber vascular grafts.
Topics: Animals; Arginine; Blood Vessel Prosthesis Implantation; Epigastric Arteries; Fibrinolytic Agents; Graft Survival; Microscopy, Electron, Scanning; Muscle Fibers, Skeletal; Muscle, Smooth, Vascular; Pipecolic Acids; Rabbits; Regional Blood Flow; Skin; Sulfonamides; Surface Properties; Tissue Transplantation; Ultrasonography | 1999 |
Heparin-induced thrombocytopenia in coronary bypass surgery.
Topics: Anticoagulants; Arginine; Coronary Artery Bypass; Heparin; Humans; Intra-Aortic Balloon Pumping; Male; Middle Aged; Myocardial Infarction; Pipecolic Acids; Platelet Aggregation Inhibitors; Platelet Count; Risk Factors; Sulfonamides; Thrombocytopenia | 1999 |
Study of the pharmacological effect of the bile salt, sodium scymnol sulfate, from Rhizoprionodon acutus. III. Protective effect of scymnol against vascular endothelial cell damage in a rat peripheral arterial occlusion model.
Topics: Alanine Transaminase; Animals; Antithrombin III; Arginine; Arterial Occlusive Diseases; Aspartate Aminotransferases; Bile Acids and Salts; Cells, Cultured; Cholestanols; Elasmobranchii; Endothelium, Vascular; L-Lactate Dehydrogenase; Male; Peripheral Vascular Diseases; Pipecolic Acids; Rats; Rats, Wistar; Sulfonamides; Ticlopidine | 1999 |
Study of the pharmacological effect of the bile salt, sodium scymnol sulfate, from Rhizoprionodon acutus. IV. Effects of naturally occurring bile alcohols, bile acids and their conjugates on lesion development and vascular endothelial cell injury in a rat
Topics: Animals; Arginine; Arterial Occlusive Diseases; Bile Acids and Salts; Cholestanols; Elasmobranchii; Endothelium, Vascular; Isoenzymes; L-Lactate Dehydrogenase; Male; Peripheral Vascular Diseases; Pipecolic Acids; Rats; Rats, Wistar; Sulfonamides | 1999 |
Design and synthesis of thrombin inhibitors: analogues of MD-805 with reduced stereogenicity and improved potency.
Topics: Animals; Antithrombins; Arginine; Cattle; Drug Design; Humans; Injections, Intravenous; Injections, Subcutaneous; Models, Molecular; Pipecolic Acids; Piperidines; Rats; Stereoisomerism; Structure-Activity Relationship; Sulfonamides; Thrombin; Thrombosis | 1999 |
In vitro antiplatelet profile of FR171113, a novel non-peptide thrombin receptor antagonist.
Topics: Arginine; Aspirin; Benzamides; Dipeptides; Dose-Response Relationship, Drug; Humans; Oligopeptides; Peptide Fragments; Pipecolic Acids; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Thrombin; Serine Endopeptidases; Sulfonamides; Thiazoles; Thiazolidines; Thrombin | 1999 |
Shear-dependent functions of the interaction between soluble von Willebrand factor and platelet glycoprotein Ib in mural thrombus formation on a collagen surface.
Topics: Antibodies, Monoclonal; Arginine; Blood Coagulation; Carrier Proteins; Collagen; Hemorheology; Humans; Image Processing, Computer-Assisted; Microscopy, Fluorescence; Microscopy, Video; Pipecolic Acids; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Solubility; Stress, Mechanical; Sulfonamides; von Willebrand Factor | 1999 |
Effects of argatroban on thrombin-induced events in cultured vascular smooth muscle cells.
Topics: Animals; Antithrombins; Arginine; Calcium; Cells, Cultured; DNA; Enzyme Activation; Matrix Metalloproteinase 2; Muscle, Smooth, Vascular; Pipecolic Acids; Rats; Sulfonamides; Thrombin | 2000 |
Argatroban, a thrombin inhibitor, decreased mortality after 10 min of forebrain ischemia in the gerbil.
Topics: Animals; Antithrombins; Arginine; Cerebral Cortex; Cerebrovascular Circulation; Death; Gerbillinae; Ischemic Attack, Transient; Pipecolic Acids; Prosencephalon; Regional Blood Flow; Sulfonamides; Time Factors | 2000 |
Antithrombotic efficacy of RPR208566, a novel factor Xa inhibitor, in a rat model of carotid artery thrombosis.
Topics: Amidines; Animals; Arginine; Benzamides; Bleeding Time; Carotid Artery Thrombosis; Dose-Response Relationship, Drug; Factor Xa Inhibitors; Fibrinolytic Agents; Heparin; Male; Partial Thromboplastin Time; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Sulfonamides | 2000 |
Thrombin inhibitor ameliorates secondary damage in rat brain injury: suppression of inflammatory cells and vimentin-positive astrocytes.
Topics: Animals; Antithrombins; Arginine; Astrocytes; Brain Injuries; Glial Fibrillary Acidic Protein; Inflammation; Macrophages; Male; Monocytes; Neutrophils; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Sulfonamides; Time Factors; Vimentin | 2000 |
Simultaneous monitoring of argatroban and its major metabolite using an HPLC method: potential clinical applications.
Topics: Anticoagulants; Arginine; Chromatography, High Pressure Liquid; Drug Monitoring; Humans; Pipecolic Acids; Sulfonamides | 1999 |
A specific thrombin inhibitor (argatroban) ameliorated cerebral blood flow in the patients with acute cerebral infarction.
Topics: Aged; Aged, 80 and over; Animals; Antithrombins; Arginine; Cerebral Infarction; Cerebrovascular Circulation; Female; Humans; Male; Middle Aged; Pipecolic Acids; Sulfonamides; Tomography, X-Ray Computed; Xenon | 2000 |
Evaluation of argatroban and DUP 714 as anticoagulants for blood gas, electrolyte and ionized calcium analyses.
Topics: Antithrombins; Arginine; Blood Gas Analysis; Boron Compounds; Calcium; Chemistry, Clinical; Electrolytes; Evaluation Studies as Topic; Humans; Hydrogen-Ion Concentration; Oligopeptides; Oximetry; Pipecolic Acids; Sulfonamides | 2000 |
Surface modification of polyethylene balloon catheters for local drug delivery.
Topics: Acrylates; Adsorption; Angioplasty, Balloon, Coronary; Animals; Antithrombins; Arginine; Biocompatible Materials; Carotid Artery Injuries; Methacrylates; Microscopy, Electron, Scanning; Pipecolic Acids; Polyethylenes; Rabbits; Sulfonamides; Surface Properties | 2000 |
Spatiotemporal dynamics of fibrin formation and spreading of active thrombin entering non-recalcified plasma by diffusion.
Topics: alpha-Macroglobulins; Antithrombins; Arginine; Blood Coagulation; Calcium; Coumarins; Diffusion; Fibrin; Fibrinogen; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Humans; Kinetics; Models, Theoretical; Pipecolic Acids; Plasma; Solutions; Sulfonamides; Thrombin | 2000 |
Lack of tPA significantly affects antithrombotic therapy by a GPIIb/IIIa antagonist, but not by a thrombin inhibitor in mice.
Topics: Animals; Arginine; Bleeding Time; Carotid Artery Thrombosis; Dose-Response Relationship, Drug; Fibrinolytic Agents; Mice; Mice, Knockout; Pipecolic Acids; Piperazines; Piperidines; Platelet Glycoprotein GPIIb-IIIa Complex; Sulfonamides; Thrombin; Thrombolytic Therapy; Tissue Plasminogen Activator; Urokinase-Type Plasminogen Activator | 2000 |
Estimating data transformations in nonlinear mixed effects models.
Topics: Arginine; Biometry; Data Interpretation, Statistical; Humans; Infant, Newborn; Infant, Premature; Likelihood Functions; Monte Carlo Method; Nonlinear Dynamics; Phenobarbital; Pipecolic Acids; Sulfonamides | 2000 |
Local antithrombotic therapy using a novel porous balloon catheter.
Topics: Angioscopy; Animals; Arginine; Catheterization; Catheterization, Peripheral; Dogs; Fibrinolytic Agents; Heparin; Iliac Artery; Pipecolic Acids; Porosity; Sulfonamides; Thrombolytic Therapy; Thrombosis | 2000 |
Pharmacokinetics of argatroban in primates: evidence on endogenous uptake.
Topics: Animals; Antithrombins; Arginine; Blood Coagulation Tests; Chromatography, High Pressure Liquid; Infusions, Intravenous; Injections, Intravenous; Macaca mulatta; Pipecolic Acids; Sulfonamides; Time Factors | 2000 |
Argatroban as an anticoagulant for both hematologic and chemical tests.
Topics: Anticoagulants; Arginine; Blood Cell Count; Chelating Agents; Chemistry, Clinical; Edetic Acid; Female; Hematology; Humans; Leukocyte Count; Male; Pipecolic Acids; Reproducibility of Results; Sulfonamides | 2000 |
The design and synthesis of thrombin inhibitors: analogues of MD805 containing non-polar surrogates for arginine at the P1 position.
Topics: Alanine; Antithrombins; Arginine; Chymotrypsin; Drug Design; Factor Xa Inhibitors; Fibrinolysin; Kallikreins; Models, Molecular; Molecular Structure; Pipecolic Acids; Serine Proteinase Inhibitors; Structure-Activity Relationship; Sulfonamides; Thiazoles; Thrombin; Trypsin | 2000 |
Anticoagulant activity and pharmacokinetic properties of a sub-cutaneously administered mixed micellar formulation of argatroban in experimental animals.
Topics: Animals; Anticoagulants; Antithrombins; Arginine; Blood Coagulation Tests; Dogs; Dose-Response Relationship, Drug; Drug Compounding; Drug Evaluation, Preclinical; Female; Half-Life; Injections, Subcutaneous; Macaca; Male; Micelles; Pipecolic Acids; Rabbits; Rats; Solubility; Sulfonamides; Time Factors | 2000 |
Activity of a sub-cutaneously administered novel mixed micellar formulation of argatroban in rat and rabbit models of venous thrombosis.
Topics: Animals; Anticoagulants; Antithrombins; Arginine; Arteriovenous Shunt, Surgical; Bleeding Time; Blood Coagulation Tests; Carotid Arteries; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Compounding; Drug Evaluation, Preclinical; Hemostatics; Heparin; Injections, Subcutaneous; Male; Micelles; Pipecolic Acids; Rabbits; Rats; Sulfonamides; Thromboplastin; Venous Thrombosis | 2000 |
Combination of a direct thrombin inhibitor and a platelet glycoprotein IIb/IIIa blocking peptide facilitates and maintains reperfusion of platelet-rich thrombus with alteplase.
Topics: Animals; Antithrombins; Arginine; Bleeding Time; Blood Flow Velocity; Blood Platelets; Disease Models, Animal; Drug Combinations; Drug Evaluation; Female; Femoral Artery; Fibrinolytic Agents; Heparin; Male; Partial Thromboplastin Time; Peptides; Peptides, Cyclic; Pipecolic Acids; Plasminogen Activators; Platelet Glycoprotein GPIIb-IIIa Complex; Rabbits; Reperfusion; Sulfonamides; Sulfoxides; Thrombosis; Tissue Plasminogen Activator | 2000 |
Argatroban approved for heparin-induced thrombocytopenia.
Topics: Antithrombins; Arginine; Half-Life; Heparin; Humans; Pipecolic Acids; Sulfonamides; Thrombocytopenia | 2000 |
Inhibitory effect of various thrombin inhibitors on shear-induced platelet function and dynamic coagulation.
Topics: Animals; Antithrombins; Arginine; Blood Coagulation; Blood Platelets; Factor Xa Inhibitors; Male; Pipecolic Acids; Rats; Rats, Wistar; Sulfonamides; Thrombin | 2000 |
Argatroban inhibits intraocular fibrin formation after vitrectomy in rabbits.
Topics: Animals; Anterior Chamber; Antithrombins; Arginine; Dose-Response Relationship, Drug; Fibrin; Lens, Crystalline; Ophthalmic Solutions; Pipecolic Acids; Postoperative Complications; Rabbits; Sulfonamides; Time Factors; Vitrectomy; Vitreous Body | 2000 |
In vitro and in vivo studies of AT-1362, a newly synthesized and orally active inhibitor of thrombin.
Topics: Administration, Oral; Amidines; Animals; Arginine; Binding, Competitive; Bleeding Time; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ferrous Compounds; Fibrinolytic Agents; Humans; Male; Molecular Structure; Partial Thromboplastin Time; Pipecolic Acids; Protein Binding; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Sulfonamides; Thrombin; Vascular Patency; Venous Thrombosis | 2000 |
Effects of an antithrombin drug in patients with subacute exacerbations of Binswanger disease.
Topics: Acute Disease; Aged; Antithrombins; Arginine; Dementia, Vascular; Female; Humans; Male; Middle Aged; Pipecolic Acids; Sulfonamides | 2000 |
The effect of argatroban on injured endothelial cells by thrombin.
Topics: Arginine; Cell Line; Culture Media, Conditioned; Dose-Response Relationship, Drug; Endothelium, Vascular; Hemostatics; Humans; Kinetics; Pipecolic Acids; Plasminogen Activator Inhibitor 1; Plasminogen Activators; Platelet Aggregation Inhibitors; Staphylococcus; Sulfonamides; Thrombin | 2000 |
Antithrombotic effects of a synthetic inhibitor of activated factor X, JTV-803, in animals.
Topics: Animals; Anticoagulants; Antithrombin III; Arginine; Bleeding Time; Factor Xa Inhibitors; Fibrinolytic Agents; Heparin, Low-Molecular-Weight; Isoquinolines; Macaca fascicularis; Male; Partial Thromboplastin Time; Peptide Hydrolases; Pipecolic Acids; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Sulfonamides; Tetrahydroisoquinolines; Thrombosis | 2001 |
Argatroban for treatment of heparin-induced thrombocytopenia.
Topics: Arginine; Health Expenditures; Hemorrhage; Heparin; Humans; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Thrombosis | 2001 |
[Improvement of cerebral perfusion with argatroban in a patient with antiphospholipid syndrome].
Topics: Adult; Antiphospholipid Syndrome; Antithrombins; Arginine; Cerebrovascular Circulation; Female; Humans; Iodine Radioisotopes; Iofetamine; Pipecolic Acids; Radionuclide Imaging; Radiopharmaceuticals; Sulfonamides | 2000 |
[Specific inhibition of thrombin activity during cardiopulmonary bypass reduces ischemia-reperfusion injury of the lung].
Topics: Animals; Antithrombins; Arginine; Cardiopulmonary Bypass; Lung Diseases; Male; Pipecolic Acids; Rabbits; Reperfusion Injury; Sulfonamides; Thrombin | 2001 |
Off-pump coronary artery bypass for a heparin-allergic patient.
Topics: Anticoagulants; Arginine; Coronary Angiography; Coronary Artery Bypass; Coronary Disease; Drug Hypersensitivity; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Sulfonamides | 2001 |
Thrombin inhibition attenuates neurodegeneration and cerebral edema formation following transient forebrain ischemia.
Topics: Animals; Antithrombins; Arginine; Aspirin; Blood Pressure; Brain Edema; Cerebrovascular Circulation; Fibrinolytic Agents; Gerbillinae; Hippocampus; Ischemic Attack, Transient; Male; Methacrylates; Microcirculation; Nerve Degeneration; Neurons; Pipecolic Acids; Sulfonamides; Survival Rate; Thrombin | 2001 |
Thrombin promotes fibroblast proliferation during the early stages of experimental radiation pneumonitis.
Topics: Animals; Antithrombin III; Antithrombins; Arginine; Biological Assay; Bronchoalveolar Lavage Fluid; Cell Division; Cell Separation; Cells, Cultured; Disease Models, Animal; Fibroblasts; Growth Substances; Lung; Male; Pipecolic Acids; Radiation Injuries, Experimental; Radiation Pneumonitis; Rats; Rats, Wistar; Specific Pathogen-Free Organisms; Sulfonamides; Thrombin | 2001 |
Broad-spectrum and selective serine protease inhibitors prevent expression of platelet-derived growth factor-BB and cerebral vasospasm after subarachnoid hemorrhage: vasospasm caused by cisternal injection of recombinant platelet-derived growth factor-BB.
Topics: Animals; Antithrombins; Arginine; Becaplermin; Benzamidines; Cerebral Arteries; Cisterna Magna; Guanidines; Immunohistochemistry; Injections; Kinetics; Male; Pipecolic Acids; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Rabbits; Radiography; Recombinant Proteins; Serine Proteinase Inhibitors; Subarachnoid Hemorrhage; Sulfonamides; Vasospasm, Intracranial | 2001 |
Direct thrombin inhibitors: are they the future of anticoagulation?
Topics: Anticoagulants; Arginine; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombin | 2001 |
A short synthesis of argatroban. a potent selective thrombin inhibitor.
Topics: Antithrombins; Arginine; Enzyme Inhibitors; Pipecolic Acids; Piperidines; Sensitivity and Specificity; Sulfonamides | 2001 |
Extension of the therapeutic window for recombinant tissue plasminogen activator with argatroban in a rat model of embolic stroke.
Topics: Animals; Antithrombins; Arginine; Brain Ischemia; Cerebral Hemorrhage; Dose-Response Relationship, Drug; Fibrin; Incidence; Infarction, Middle Cerebral Artery; Intracranial Embolism; Male; Pipecolic Acids; Rats; Rats, Wistar; Recombinant Proteins; Stroke; Sulfonamides; Time Factors; Tissue Plasminogen Activator | 2001 |
Anticoagulation with a selective thrombin inhibitor in a woman with heparin-induced thrombocytopenia.
Topics: Anticoagulants; Arginine; Catheterization, Central Venous; Female; Heparin; Humans; Middle Aged; Pipecolic Acids; Postoperative Complications; Sulfonamides; Thrombectomy; Thrombocytopenia; Thrombosis | 2001 |
Argatroban.
Topics: Antithrombins; Arginine; Drug Interactions; Humans; Pipecolic Acids; Sulfonamides; Thrombosis | 2001 |
The use of argatroban as an anticoagulant for cardiopulmonary bypass in cardiac operations.
Topics: Adult; Anticoagulants; Antithrombin III Deficiency; Aortic Valve; Arginine; Cardiopulmonary Bypass; Heart Valve Prosthesis Implantation; Humans; Male; Pipecolic Acids; Sulfonamides | 2001 |
Changes in blood viscosity by heparin and argatroban.
Topics: Adult; Anticoagulants; Arginine; Blood Viscosity; Dose-Response Relationship, Drug; Heparin; Humans; In Vitro Techniques; Male; Pipecolic Acids; Sulfonamides | 2001 |
The antithrombotic efficacy of AT-1459, a novel, direct thrombin inhibitor, in rat models of venous and arterial thrombosis.
Topics: Administration, Oral; Amidines; Animals; Arginine; Azepines; Bleeding Time; Carotid Artery Thrombosis; Dalteparin; Drug Evaluation, Preclinical; Fibrinolytic Agents; Hemorrhage; Humans; Infusions, Intravenous; Injections, Intravenous; Male; Molecular Structure; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Sulfonamides; Thrombin; Vena Cava, Inferior; Venous Thrombosis; Warfarin | 2001 |
Successful use of argatroban as an anticoagulant in burn-related severe acquired antithrombin III deficiency after heparin failure.
Topics: Accidents, Home; Adult; Anticoagulants; Antithrombin III Deficiency; Arginine; Burns; Cardiovascular Agents; Coronary Vasospasm; Debridement; Drug Therapy, Combination; Explosions; Humans; Male; Pipecolic Acids; Sulfonamides; Ventricular Dysfunction, Left; Warfarin | 2001 |
Inhibitors of fibrinolytic components play different roles in the formation and removal of arterial thrombus in mice.
Topics: alpha-2-Antiplasmin; Animals; Arginine; Bleeding Time; Blood Coagulation; Carotid Artery Injuries; Endothelium, Vascular; Mice; Mice, Inbred C57BL; Mice, Knockout; Pipecolic Acids; Piperazines; Piperidines; Plasminogen Activator Inhibitor 1; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Serine Proteinase Inhibitors; Sulfonamides; Thrombin; Thrombin Time; Thrombosis; Vascular Patency | 2002 |
Platelet shape changes and adhesion under high shear flow.
Topics: Androstadienes; Arginine; Blood Platelets; Calcium; Cell Movement; Cytoplasm; Egtazic Acid; Humans; Microscopy, Electron, Scanning; Microscopy, Fluorescence; Pipecolic Acids; Platelet Adhesiveness; Signal Transduction; Stress, Mechanical; Sulfonamides; Wortmannin | 2002 |
[Intraoperative management for a patient with heparin-induced thrombocytopenia (HIT) undergoing off-pump coronary bypass surgery using argatroban, a direct thrombin inhibitor].
Topics: Aged; Antithrombins; Arginine; Coronary Artery Bypass; Fibrinolytic Agents; Heparin; Humans; Intraoperative Care; Male; Pipecolic Acids; Sulfonamides; Thrombocytopenia | 2002 |
Enhancement of endogenous plasminogen activator-induced thrombolysis by argatroban and APC and its control by TAFI, measured in an arterial thrombolysis model in vivo using rat mesenteric arterioles.
Topics: Animals; Arginine; Arterial Occlusive Diseases; Arterioles; Binding, Competitive; Carboxypeptidase B2; Enzyme Activation; Enzyme Inhibitors; Fibrinolysis; Fibrinolytic Agents; Image Processing, Computer-Assisted; Lasers; Male; Mesenteric Arteries; Models, Animal; Pipecolic Acids; Plant Proteins; Plasminogen Activators; Protease Inhibitors; Protein C; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Sulfonamides; Swine; Thrombosis | 2002 |
Substitution of Gly-548 to Ala in the substrate binding pocket of prothrombin Perijá leads to the loss of thrombin proteolytic activity.
Topics: Alanine; Amino Acid Substitution; Antithrombin III; Arginine; Binding Sites; Catalytic Domain; Codon; DNA Mutational Analysis; Enzyme Activation; Enzyme Inhibitors; Exons; Factor V; Factor Xa; Glycine; Humans; Models, Molecular; Pipecolic Acids; Polymorphism, Single-Stranded Conformational; Protein Conformation; Prothrombin; Serine; Structure-Activity Relationship; Sulfonamides; Thrombin | 2002 |
Long-term inhibition of nitric oxide synthesis increases arterial thrombogenecity in rat carotid artery.
Topics: Administration, Oral; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antithrombins; Arginine; Blood Flow Velocity; Blood Pressure; Carotid Arteries; Carotid Artery Thrombosis; Enzyme Inhibitors; Gene Expression Regulation; Heart Rate; Imidazoles; Imidazolidines; Injections, Intravenous; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peptidyl-Dipeptidase A; Pipecolic Acids; Platelet Aggregation; Prothrombin Time; Rats; Rats, Inbred WKY; Sulfonamides; Thromboplastin; Transcription, Genetic | 2002 |
An antibody that binds to primary specific pocket-associated structure in the active site of bovine thrombin.
Topics: Animals; Antibodies, Monoclonal; Arginine; Binding Sites; Binding, Competitive; Cattle; Chromatography, Affinity; Cloning, Molecular; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Fibrinogen; Hybridomas; Immunoglobulin G; Mice; Mice, Inbred BALB C; Pipecolic Acids; Protein Binding; Rabbits; Rats; Rats, Wistar; Spleen; Sulfonamides; Thrombin | 2002 |
Argatroban therapy does not generate antibodies that alter its anticoagulant activity in patients with heparin-induced thrombocytopenia.
Topics: Antibodies; Anticoagulants; Arginine; Dose-Response Relationship, Drug; Heparin; Humans; Partial Thromboplastin Time; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Thrombosis | 2002 |
Combined argatroban and edaravone caused additive neuroprotection against 15 min of forebrain ischemia in gerbils.
Topics: Animals; Anticoagulants; Antipyrine; Arginine; Body Water; Brain Edema; Brain Ischemia; Cerebral Infarction; Cerebrovascular Circulation; Drug Interactions; Drug Therapy, Combination; Edaravone; Endothelium, Vascular; Free Radical Scavengers; Free Radicals; Gerbillinae; Male; Nerve Degeneration; Neuroprotective Agents; Pipecolic Acids; Prosencephalon; Reperfusion Injury; Sulfonamides | 2002 |
[Heparin-induced thrombocytopenia: the clinical picture and treatment].
Topics: Anticoagulants; Arginine; Autoantibodies; Heparin; Humans; Pipecolic Acids; Platelet Aggregation; Sulfonamides; Thrombocytopenia | 2002 |
Comment: treatment of heparin-induced thrombocytopenia.
Topics: Anticoagulants; Arginine; Heparin; Hirudins; Humans; International Normalized Ratio; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombin; Thrombocytopenia; Warfarin | 2002 |
Venous limb gangrene during overlapping therapy with warfarin and a direct thrombin inhibitor for immune heparin-induced thrombocytopenia.
Topics: Aged; Aged, 80 and over; Amputation, Surgical; Anticoagulants; Arginine; Autoimmune Diseases; Catheterization, Central Venous; Contraindications; Drug Administration Schedule; Drug Therapy, Combination; Female; Gangrene; Heparin; Hirudin Therapy; Hirudins; Humans; International Normalized Ratio; Leg; Male; Middle Aged; Necrosis; Pipecolic Acids; Protein C Deficiency; Recombinant Proteins; Sulfonamides; Surgical Wound Infection; Thrombin; Thrombocytopenia; Thrombophlebitis; Warfarin | 2002 |
Monitoring of anticoagulant effects of direct thrombin inhibitors.
Topics: Anticoagulants; Arginine; Azetidines; Benzylamines; Blood Coagulation Tests; Drug Monitoring; Glycine; Heparin; Hirudins; Humans; Pipecolic Acids; Recombinant Proteins; Sensitivity and Specificity; Sulfonamides; Thrombin | 2002 |
Visual compatibility of argatroban with selected drugs.
Topics: Antithrombins; Arginine; Chemical Precipitation; Chemistry, Pharmaceutical; Color; Drug Incompatibility; Drug Stability; Drug Storage; Infusions, Intravenous; Pipecolic Acids; Sulfonamides; Time Factors | 2002 |
Influence of lepirudin, argatroban, and melagatran on prothrombin time and additional effect of oral anticoagulation.
Topics: Administration, Oral; Anticoagulants; Arginine; Azetidines; Benzylamines; Drug Synergism; Glycine; Hirudins; Humans; Phenprocoumon; Pipecolic Acids; Prothrombin Time; Recombinant Proteins; Sulfonamides | 2002 |
Argatroban anticoagulation during percutaneous coronary intervention in patients with heparin-induced thrombocytopenia.
Topics: Adult; Angioplasty, Balloon, Coronary; Anticoagulants; Antithrombins; Arginine; Atherectomy, Coronary; Female; Heparin; Humans; Male; Pipecolic Acids; Stents; Sulfonamides; Thrombocytopenia; Thrombosis; Treatment Outcome | 2002 |
Argatroban for percutaneous coronary interventions: hit or miss?
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Arginine; Heparin; Humans; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Thrombosis | 2002 |
Preventing complications in heparin-induced thrombocytopenia. Alternative anticoagulants are improving patient outcomes.
Topics: Anticoagulants; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Drug Combinations; Heparin; Heparinoids; Heparitin Sulfate; Hirudin Therapy; Hirudins; Humans; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2002 |
Direct antithrombin agents ameliorate disseminated intravascular coagulation in suspected heparin-induced thrombocytopenia thrombosis syndrome.
Topics: Adult; Aged; Arginine; Disseminated Intravascular Coagulation; Female; Fibrinolytic Agents; Heparin; Hirudins; Humans; Male; Middle Aged; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2002 |
Studies on the different modes of action of the anticoagulant protease inhibitors DX-9065a and Argatroban. II. Effects on fibrinolysis.
Topics: Anticoagulants; Arginine; Blood Coagulation; Fibrinolysis; Humans; Kinetics; Naphthalenes; Pipecolic Acids; Propionates; Sulfonamides; Thrombomodulin; Thromboplastin | 2002 |
Low-molecular weight heparin: treatment failure in a patient with primary antiphospholipid antibody syndrome.
Topics: Adolescent; Anticoagulants; Antiphospholipid Syndrome; Arginine; Arm; Enoxaparin; Female; Folic Acid; Heparin, Low-Molecular-Weight; Humans; International Normalized Ratio; Pipecolic Acids; Pulmonary Embolism; Sulfonamides; Treatment Failure; Treatment Outcome; Venous Thrombosis; Warfarin | 2002 |
Delayed argatroban treatment reduces edema in a rat model of intracerebral hemorrhage.
Topics: Animals; Antithrombins; Arginine; Brain; Brain Chemistry; Brain Edema; Cerebral Hemorrhage; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Hemoglobins; Infusions, Parenteral; Male; Microinjections; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Stereotaxic Techniques; Sulfonamides; Time Factors; Treatment Outcome; Water | 2002 |
Thrombosis increases circulatory hepatocyte growth factor by degranulation of mast cells.
Topics: Animals; Anticoagulants; Arginine; Carotid Artery Thrombosis; Cell Degranulation; Disease Models, Animal; Disease Progression; Hepatocyte Growth Factor; Histamine; Male; Mast Cells; p-Methoxy-N-methylphenethylamine; Pipecolic Acids; Proto-Oncogene Proteins c-kit; Rats; Rats, Inbred Strains; Rats, Wistar; Reperfusion; Sulfonamides; Thrombin | 2002 |
Studies on the different modes of action of the anticoagulant protease inhibitors DX-9065a and Argatroban. I. Effects on thrombin generation.
Topics: Anticoagulants; Arginine; Binding, Competitive; Blood Coagulation; Humans; Kinetics; Models, Theoretical; Naphthalenes; Pipecolic Acids; Platelet Aggregation Inhibitors; Propionates; Serine Proteinase Inhibitors; Sulfonamides; Thrombin | 2002 |
Acute pulmonary thromboembolism induced by prophylactic heparin use and a heparin-coated catheter: a case of heparin-induced thrombocytopenia and thrombosis syndrome.
Topics: Acute Disease; Anticoagulants; Arginine; Catheterization; Catheterization, Central Venous; Coated Materials, Biocompatible; Female; Heparin; Humans; Middle Aged; Pipecolic Acids; Pulmonary Embolism; Radionuclide Imaging; Sulfonamides; Syndrome; Thrombocytopenia; Thromboembolism; Tomography, X-Ray Computed; Ultrasonography | 2003 |
Argatroban in adult extracorporeal membrane oxygenation.
Topics: Adult; Anticoagulants; Antithrombins; Arginine; Coated Materials, Biocompatible; Enzyme-Linked Immunosorbent Assay; Extracorporeal Membrane Oxygenation; Female; Heparin; Humans; Pipecolic Acids; Sulfonamides; Texas; Thrombocytopenia | 2002 |
Argatroban, specific thrombin inhibitor, induced phenotype change of cultured rabbit vascular smooth muscle cells.
Topics: Animals; Aorta; Arginine; Biomarkers; Blotting, Western; Cells, Cultured; Dose-Response Relationship, Drug; In Situ Hybridization; Male; Muscle, Smooth, Vascular; Myosin Heavy Chains; Phenotype; Pipecolic Acids; Protein Isoforms; Rabbits; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Thrombin | 2003 |
Heparin-induced thrombocytopenia and cardiopulmonary bypass: perioperative argatroban use.
Topics: Adult; Anticoagulants; Antithrombins; Arginine; Cardiopulmonary Bypass; Female; Heparin; Humans; Pipecolic Acids; Sulfonamides; Thrombocytopenia | 2003 |
Argatroban as an alternative anticoagulant for patients with heparin allergy during coronary bypass surgery.
Topics: Aged; Anticoagulants; Arginine; Coronary Artery Bypass; Dose-Response Relationship, Drug; Drug Hypersensitivity; Heparin; Humans; Lymphocyte Activation; Male; Pipecolic Acids; Sulfonamides | 2003 |
Hemostatic analysis of a patient undergoing off-pump coronary artery bypass surgery with argatroban anticoagulation.
Topics: Aged; Anticoagulants; Arginine; Colitis; Coronary Artery Bypass; Fatal Outcome; Fibrinogen; Hemostasis; Heparin; Humans; International Normalized Ratio; Male; Partial Thromboplastin Time; Pipecolic Acids; Platelet Count; Prothrombin Time; Sulfonamides; Thrombelastography; Thrombin; Thrombocytopenia; Whole Blood Coagulation Time | 2003 |
Effects of argatroban and heparin on thrombus formation and tissue plasminogen activator-induced thrombolysis in a microvascular thrombosis model.
Topics: Animals; Arginine; Cricetinae; Disease Models, Animal; Drug Interactions; Fibrinolytic Agents; Heparin; Mesocricetus; Microcirculation; Partial Thromboplastin Time; Pipecolic Acids; Sulfonamides; Thrombolytic Therapy; Thrombosis; Time Factors; Tissue Plasminogen Activator | 2003 |
Anticoagulation in acute cardiac care in patients with chronic kidney disease.
Topics: Anticoagulants; Antithrombins; Arginine; Chronic Disease; Coronary Disease; Heparin; Heparin, Low-Molecular-Weight; Hirudin Therapy; Hirudins; Humans; Kidney Diseases; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; United States | 2003 |
Characteristics of the hemostatic action of KFA-1411, an inhibitor of coagulation factor Xa (FXa), in humans and various animals.
Topics: Animals; Anticoagulants; Arginine; Blood Coagulation; Dogs; Factor Xa Inhibitors; Haplorhini; Humans; Male; Mice; Models, Animal; Pipecolic Acids; Piperidines; Rabbits; Rats; Rats, Wistar; Serine Endopeptidases; Sulfonamides | 2003 |
Excessive argatroban anticoagulation for heparin-induced thrombocytopenia.
Topics: Aged; Anticoagulants; Arginine; Critical Illness; Drug Overdose; Female; Heparin; Humans; Liver Function Tests; Male; Middle Aged; Pipecolic Acids; Sulfonamides; Thrombocytopenia | 2003 |
Suppression of argatroban-induced endogenous thrombolysis by PKSI-527, and antibodies to TPA and UPA, evaluated in a rat arterial thrombolysis model.
Topics: Animals; Antibodies; Arginine; Drug Antagonism; Fibrinolysin; Fibrinolysis; Fibrinolytic Agents; Kallikreins; Male; Mesenteric Arteries; Phenylalanine; Pipecolic Acids; Plasma Kallikrein; Rats; Rats, Wistar; Sulfonamides; Thrombolytic Therapy; Thrombosis; Tissue Plasminogen Activator; Tranexamic Acid; Urokinase-Type Plasminogen Activator | 2003 |
Successful use of Argatroban as a heparin substitute during cardiopulmonary bypass: heparin-induced thrombocytopenia in a high-risk cardiac surgical patient.
Topics: Aged; Anticoagulants; Antithrombins; Arginine; Cardiopulmonary Bypass; Female; Heparin; Humans; Pipecolic Acids; Risk Factors; Sulfonamides; Thrombin Time; Thrombocytopenia; Whole Blood Coagulation Time | 2003 |
Obstinate thrombosis during percutaneous coronary intervention in a case with heparin-induced thrombocytopenia with thrombosis syndrome successfully treated by argatroban anticoagulant therapy.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Arginine; Cardiac Catheterization; Coronary Stenosis; Coronary Thrombosis; Follow-Up Studies; Heparin; Humans; Male; Middle Aged; Myocardial Infarction; Pipecolic Acids; Radiography; Risk Assessment; Sulfonamides; Syndrome; Thrombocytopenia; Treatment Outcome | 2003 |
Direct thrombin inhibitors during PCI.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Arginine; Coronary Stenosis; Coronary Thrombosis; Follow-Up Studies; Heparin; Humans; Myocardial Infarction; Pipecolic Acids; Radiography; Risk Assessment; Sulfonamides; Thrombocytopenia; Treatment Outcome | 2003 |
Argatroban attenuates leukocyte- and platelet-endothelial cell interactions after transient retinal ischemia.
Topics: Animals; Arginine; Blood Platelets; Cell Adhesion; Disease Models, Animal; Endothelium, Vascular; Gene Expression; Intercellular Adhesion Molecule-1; Ischemia; Leukocytes; Male; P-Selectin; Partial Thromboplastin Time; Pipecolic Acids; Platelet Aggregation Inhibitors; Prothrombin Time; Rats; Rats, Long-Evans; Reperfusion; Retina; Retinal Diseases; Retinal Vessels; RNA, Messenger; Sulfonamides; Thrombin; Treatment Outcome; Vascular Patency | 2003 |
Predicting the pharmacology of thrombin inhibitors.
Topics: Anticoagulants; Arginine; Azetidines; Benzylamines; Blood Coagulation; Computer Simulation; Dose-Response Relationship, Drug; Glycine; Hirudins; Humans; Kinetics; Models, Cardiovascular; Oligopeptides; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombin | 2003 |
The thrombin inhibitor argatroban does not influence the endothelium-dependent relaxant and contractile responses of isolated rabbit carotid arteries.
Topics: Acetylcholine; Animals; Antithrombins; Arginine; Carotid Arteries; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Drug Therapy, Combination; Endothelium, Vascular; Injections, Intravenous; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Organ Culture Techniques; Phenylephrine; Pipecolic Acids; Rabbits; Serotonin; Sulfonamides | 2003 |
Heparin-induced thrombocytopenia--recognition and treatment.
Topics: Anticoagulants; Arginine; Heparin; Hirudin Therapy; Humans; Nursing Assessment; Perioperative Nursing; Pipecolic Acids; Sulfonamides; Thrombocytopenia | 2003 |
Inhibition of arterial thrombosis by a protease-activated receptor 1 antagonist, FR171113, in the guinea pig.
Topics: Animals; Arginine; Benzamides; Bleeding Time; Blood Coagulation; Carotid Artery Thrombosis; Chlorides; Dose-Response Relationship, Drug; Ferric Compounds; Guinea Pigs; Heparin; Injections, Subcutaneous; Male; Pipecolic Acids; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptor, PAR-1; Receptors, Thrombin; Sulfonamides; Thiazoles; Thiazolidines | 2003 |
Effects of argatroban as an anticoagulant for haemodialysis in patients with antithrombin III deficiency.
Topics: Aged; Anticoagulants; Antithrombin III Deficiency; Arginine; Female; Hematocrit; Humans; Kidney Failure, Chronic; Male; Middle Aged; Pipecolic Acids; Renal Dialysis; Retrospective Studies; Sulfonamides | 2003 |
Argatroban for heparin-induced thrombocytopenia in hepato-renal failure and CVVHD.
Topics: Acute Disease; Adult; Anticoagulants; Arginine; Fatal Outcome; Heparin; Humans; Infusions, Intravenous; Liver Failure; Male; Pipecolic Acids; Renal Dialysis; Renal Insufficiency; Sulfonamides; Thrombocytopenia; Venous Thrombosis | 2003 |
Decreased argatroban clearance unaffected by hemodialysis in anasarca.
Topics: Acute Kidney Injury; Arginine; Edema; Female; Humans; Middle Aged; Pipecolic Acids; Renal Dialysis; Sulfonamides; Thrombin; Thrombosis | 2003 |
Pharmacologic platelet anesthesia by glycoprotein IIb/IIIa complex antagonist and argatroban during in vitro extracorporeal circulation.
Topics: Abciximab; Alprostadil; Anesthesia; Annexin A5; Antibodies, Monoclonal; Anticoagulants; Arginine; Blood Platelets; Dipeptides; Dose-Response Relationship, Drug; Drug Combinations; Dual Specificity Phosphatase 2; Extracorporeal Circulation; Heparin; Humans; Immunoglobulin Fab Fragments; P-Selectin; Pipecolic Acids; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Glycoprotein GPIb-IX Complex; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoprotein IIb; Protein Phosphatase 2; Protein Tyrosine Phosphatases; Sulfonamides; Treatment Outcome; von Willebrand Factor | 2003 |
Antithrombotic properties of a direct thrombin inhibitor with a prolonged half-life and AT-mediated factor Xa inhibitory activity.
Topics: Animals; Antithrombin III; Arginine; Blood Coagulation Tests; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Factor Xa Inhibitors; Fibrinolytic Agents; Fondaparinux; Half-Life; Hemorrhage; Heparin; Male; Molecular Structure; Oligosaccharides; Pipecolic Acids; Polysaccharides; Rabbits; Rats; Rats, Wistar; Sulfonamides; Thrombin; Thrombolytic Therapy; Thrombosis | 2003 |
Argatroban inhibits staphylothrombin.
Topics: Arginine; Blood Coagulation; Coagulase; Fibrin; Humans; Pipecolic Acids; Staphylococcus aureus; Sulfonamides; Thrombin | 2003 |
Argatroban for off-pump coronary artery bypass surgery.
Topics: Anticoagulants; Arginine; Blood Coagulation Tests; Coronary Artery Bypass; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides | 2003 |
Clinician update: direct thrombin inhibitors in acute coronary syndromes.
Topics: Acute Disease; Arginine; Coronary Disease; Fibrinolytic Agents; Hirudin Therapy; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombin | 2003 |
Vascular surgery using argatroban in a patient with a history of heparin-induced thrombocytopenia.
Topics: Aged; Anticoagulants; Arginine; Cardiovascular Surgical Procedures; Heparin; Humans; Male; Perioperative Care; Peripheral Vascular Diseases; Pipecolic Acids; Sulfonamides; Thrombocytopenia | 2003 |
Treatment options for heparin-induced thrombocytopenia.
Topics: Antithrombins; Arginine; Heparin; Hirudins; Humans; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Thrombosis; United States | 2003 |
Antithrombotic effects of FK419, a novel nonpeptide platelet GPIIb/IIIa antagonist, in a guinea pig photochemically induced middle cerebral artery thrombosis model: comparison with ozagrel and argatroban.
Topics: Animals; Antithrombins; Arginine; Blood Coagulation; Blood Platelets; Brain Ischemia; Disease Models, Animal; Guinea Pigs; Infarction, Middle Cerebral Artery; Male; Methacrylates; Pipecolic Acids; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Reperfusion Injury; Sulfonamides; Thromboxane B2 | 2004 |
Differential effects of DX-9065a, argatroban, and synthetic pentasaccharide on tissue thromboplastin inhibition test and dilute Russell's viper venom test.
Topics: Anticoagulants; Arginine; Blood Coagulation; Dose-Response Relationship, Drug; Female; Humans; Kinetics; Male; Naphthalenes; Oligosaccharides; Partial Thromboplastin Time; Pipecolic Acids; Propionates; Prothrombin Time; Sulfonamides | 2003 |
Argatroban use during pediatric interventional cardiac catheterization.
Topics: Antithrombins; Arginine; Cardiac Catheterization; Child; Embolization, Therapeutic; Fibrinolytic Agents; Heart Diseases; Heparin; Humans; Male; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Thrombosis | 2004 |
Influence of conduction disturbances on clinical outcome in patients with acute myocardial infarction receiving thrombolysis (results from the ARGAMI-2 study).
Topics: Arginine; Electrocardiography; Female; Heart Block; Heparin; Hospitalization; Humans; Intensive Care Units; Israel; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Pipecolic Acids; Prospective Studies; Randomized Controlled Trials as Topic; Severity of Illness Index; Streptokinase; Sulfonamides; Survival Analysis; Thrombolytic Therapy | 2004 |
Predictive value of serial platelet count and VEGF determination for the management of DIC in the Crow-Fukase (POEMS) syndrome.
Topics: Antithrombins; Arginine; Disseminated Intravascular Coagulation; Glucocorticoids; Humans; Male; Methylprednisolone Hemisuccinate; Middle Aged; Pipecolic Acids; Platelet Count; POEMS Syndrome; Predictive Value of Tests; Sulfonamides; Vascular Endothelial Growth Factor A | 2003 |
Argatroban as anticoagulant in cardiopulmonary bypass in an infant and attempted reversal with recombinant activated factor VII.
Topics: Anticoagulants; Arginine; Coronary Artery Bypass; Factor VII; Factor VIIa; Heparin; Humans; Infant; Male; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2004 |
Effect of renal function on the pharmacodynamics of argatroban.
Topics: Aged; Arginine; Creatinine; Data Collection; Drug Administration Schedule; Humans; Injections, Intravenous; Kidney; Kidney Function Tests; Liver Function Tests; Metabolic Clearance Rate; Middle Aged; Partial Thromboplastin Time; Patient Selection; Pipecolic Acids; Prospective Studies; Sulfonamides; Treatment Outcome | 2004 |
Mild hypothermia enhances the neuroprotective effects of a selective thrombin inhibitor following transient focal ischemia in rats.
Topics: Animals; Antithrombins; Arginine; Brain Edema; Cerebral Cortex; Cerebral Infarction; Hypothermia, Induced; Ischemic Attack, Transient; Male; Neuroprotective Agents; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Sulfonamides | 2003 |
Effect of delayed argatroban treatment on intracerebral hemorrhage-induced edema in the rat.
Topics: Animals; Antithrombins; Arginine; Brain; Brain Edema; Cerebral Hemorrhage; Collagenases; Drug Administration Schedule; Hematoma; Injections; Injections, Intraperitoneal; Male; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Sulfonamides | 2003 |
A thrombin inhibitor reduces brain edema, glioma mass and neurological deficits in a rat glioma model.
Topics: Animals; Antithrombins; Arginine; Brain Edema; Brain Neoplasms; Cell Line, Tumor; Glioma; Immunohistochemistry; Nervous System Diseases; Pipecolic Acids; Rats; Rats, Inbred F344; Sulfonamides; Thrombin | 2003 |
Failure of argatroban anticoagulation during off-pump coronary artery bypass surgery.
Topics: Aged; Angina, Unstable; Antibodies; Anticoagulants; Arginine; Cardiopulmonary Bypass; Coronary Artery Bypass; Coronary Restenosis; Dose-Response Relationship, Drug; Graft Occlusion, Vascular; Heparin; Humans; Male; Myocardial Revascularization; Partial Thromboplastin Time; Pipecolic Acids; Reoperation; Stents; Sulfonamides; Treatment Failure | 2004 |
Argatroban dosing in intensive care patients with acute renal failure and liver dysfunction.
Topics: Acute Kidney Injury; Aged; Arginine; Critical Care; Critical Illness; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Heparin; Humans; Infusions, Parenteral; International Normalized Ratio; Liver Diseases; Male; Middle Aged; Partial Thromboplastin Time; Pipecolic Acids; Renal Replacement Therapy; Sulfonamides; Thrombocytopenia; Transaminases | 2004 |
Stroke in patients with heparin-induced thrombocytopenia and the effect of argatroban therapy.
Topics: Aged; Anticoagulants; Arginine; Cerebral Infarction; Critical Care; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Heparin; Hospital Mortality; Humans; Intracranial Embolism; Male; Middle Aged; Odds Ratio; Partial Thromboplastin Time; Pipecolic Acids; Platelet Aggregation Inhibitors; Retrospective Studies; Sulfonamides; Survival Rate; Thrombocytopenia | 2004 |
Effect of direct thrombin inhibitors, bivalirudin, lepirudin, and argatroban, on prothrombin time and INR values.
Topics: Antithrombins; Arginine; Dose-Response Relationship, Drug; Hirudins; Humans; In Vitro Techniques; International Normalized Ratio; Peptide Fragments; Pipecolic Acids; Prothrombin Time; Recombinant Proteins; Sulfonamides | 2004 |
Heparinless cardiopulmonary bypass with argatroban in dogs.
Topics: Animals; Anticoagulants; Arginine; Blood Coagulation; Cardiopulmonary Bypass; Dogs; Dose-Response Relationship, Drug; Fibrinolysis; Heparin; Intraoperative Care; Kidney; Pipecolic Acids; Postoperative Complications; Sulfonamides; Thrombosis | 2004 |
Synthetic selective inhibitors of coagulation factor Xa strongly inhibit thrombin generation without affecting initial thrombin forming time necessary for platelet activation in hemostasis.
Topics: Anticoagulants; Arginine; Blood Platelets; Cells, Cultured; Enzyme Inhibitors; Factor Xa Inhibitors; Hemostasis; Humans; Naphthalenes; Partial Thromboplastin Time; Pipecolic Acids; Piperidines; Platelet Activation; Propionates; Prothrombin Time; Pyridines; Sulfonamides; Tetrahydroisoquinolines; Thrombin | 2004 |
Collagen-induced generation of platelet-derived microparticles in whole blood is dependent on ADP released from red blood cells and calcium ions.
Topics: Adenosine Diphosphate; Arginine; Blood Platelets; Calcium; Collagen; Crotalid Venoms; Erythrocytes; Flow Cytometry; Humans; Lectins, C-Type; Membrane Proteins; Particle Size; Pipecolic Acids; Platelet Activation; Platelet Membrane Glycoproteins; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Sulfonamides | 2004 |
Intraoperative management of a congenital antithrombin deficient patient on chronic hemodialysis.
Topics: Aged; Anticoagulants; Antithrombins; Arginine; Benzamidines; Guanidines; Humans; Intraoperative Care; Kidney Failure, Chronic; Male; Parathyroidectomy; Pipecolic Acids; Renal Dialysis; Sulfonamides | 2004 |
Comparing direct thrombin inhibitors using aPTT, ecarin clotting times, and thrombin inhibitor management testing.
Topics: Arginine; Blood Coagulation; Dose-Response Relationship, Drug; Endopeptidases; Fibrinolytic Agents; Hirudins; Humans; In Vitro Techniques; Partial Thromboplastin Time; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombin | 2004 |
Ability of anti-glycoprotein IIb/IIIa agents to dissolve platelet thrombi formed on a collagen surface under blood flow conditions.
Topics: Abciximab; Adult; Antibodies, Monoclonal; Anticoagulants; Arginine; Blood Platelets; Collagen; Eptifibatide; Fibrinolytic Agents; Hemorheology; Humans; Immunoglobulin Fab Fragments; In Vitro Techniques; Peptides; Pipecolic Acids; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Sulfonamides; Thrombosis; Tirofiban; Tyrosine | 2004 |
Acute ischemic stroke successfully treated using sequenced intravenous and intra-arterial thrombolysis and argatroban anticoagulation: a case study.
Topics: Acute Disease; Adult; Anticoagulants; Arginine; Brain Ischemia; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Male; Pipecolic Acids; Stroke; Sulfonamides | 2004 |
Argatroban usage for anticoagulation for ECMO on a post-cardiac patient with heparin-induced thrombocytopenia.
Topics: Anticoagulants; Arginine; Blood Coagulation; Cardiopulmonary Bypass; Extracorporeal Membrane Oxygenation; Fatal Outcome; Heparin; Humans; Hypoplastic Left Heart Syndrome; Infant, Newborn; Pipecolic Acids; Postoperative Care; Sulfonamides; Thrombocytopenia | 2004 |
Heparin-induced thrombocytopenia and thrombosis in a patient with polycythemia vera.
Topics: Aged; Arginine; Female; Follow-Up Studies; Heparin; Humans; Japan; Pipecolic Acids; Polycythemia Vera; Pulmonary Embolism; Risk Assessment; Severity of Illness Index; Sulfonamides; Thrombocytopenia; Thrombosis; Treatment Outcome | 2004 |
Effects of pentasaccharide (fondaparinux) and direct thrombin inhibitors on coagulation testing.
Topics: Antithrombins; Arginine; Blood Coagulation Tests; Fondaparinux; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Sulfonamides | 2004 |
Monitoring direct thrombin inhibitors: time for standardization.
Topics: Anticoagulants; Arginine; Coronary Artery Bypass; Factor VII; Humans; Pipecolic Acids; Sulfonamides; Thrombin; Thrombocytopenia; Whole Blood Coagulation Time | 2004 |
[Use of argatroban as a substitute for heparin in a patient with suspected HIT type II undergoing carotid endarterectomy].
Topics: Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Anticoagulants; Arginine; Carotid Artery, Internal; Endarterectomy, Carotid; Female; Heparin; Humans; Monitoring, Intraoperative; Pipecolic Acids; Preoperative Care; Sulfonamides; Thrombocytopenia; Whole Blood Coagulation Time | 2004 |
The effects of argatroban on thrombin generation and hemostatic activation in vitro.
Topics: Aged; Anticoagulants; Antithrombins; Arginine; Blood Platelets; Dose-Response Relationship, Drug; Drug Synergism; Female; Hemostasis; Heparin; Humans; In Vitro Techniques; International Normalized Ratio; Male; Middle Aged; Partial Thromboplastin Time; Pipecolic Acids; Platelet Count; Serine Proteinase Inhibitors; Sulfonamides; Thrombin; Whole Blood Coagulation Time | 2004 |
Argatroban as an alternative to heparin in extracorporeal membrane oxygenation circuits.
Topics: Arginine; Biomarkers; Blood Coagulation Tests; Equipment Failure; Extracorporeal Membrane Oxygenation; Heparin; Humans; Pipecolic Acids; Sulfonamides; Thrombelastography; Thrombin; Thrombosis | 2004 |
Thrombin inhibitor, argatroban, prevents tumor cell migration and bone metastasis.
Topics: Animals; Antineoplastic Agents; Antithrombins; Arginine; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Drug; Melanoma, Experimental; Mice; Pipecolic Acids; Sulfonamides | 2004 |
Severe argatroban-induced coagulopathy in a patient with a history of heparin-induced thrombocytopenia.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aortic Valve; Aortic Valve Stenosis; Arginine; Blood Coagulation Disorders; Heart Valve Prosthesis Implantation; Heparin; Humans; Male; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Thrombosis | 2004 |
Argatroban as a heparin substitute in cases of heparin-induced thrombocytopenia.
Topics: Anticoagulants; Arginine; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Heparin; Humans; International Normalized Ratio; Pipecolic Acids; Sulfonamides; Thrombocytopenia | 2004 |
Compatibility of argatroban with selected cardiovascular agents.
Topics: Amiodarone; Anticoagulants; Arginine; Cardiovascular Agents; Drug Interactions; Drug Therapy, Combination; Fenoldopam; Furosemide; Humans; Infusions, Parenteral; Lidocaine; Milrinone; Natriuretic Peptide, Brain; Nitroglycerin; Nitroprusside; Pipecolic Acids; Sulfonamides; Vasopressins | 2004 |
Spontaneous atrioventricular groove disruption during off-pump coronary artery bypass grafting.
Topics: Aged; Anticoagulants; Arginine; Cardiopulmonary Bypass; Coronary Artery Bypass, Off-Pump; Coronary Stenosis; Emergencies; Fatal Outcome; Female; Heart Injuries; Heparin; Humans; Hypertension, Pulmonary; Internal Mammary-Coronary Artery Anastomosis; Intraoperative Complications; Mitral Valve; Myocardial Infarction; Pipecolic Acids; Postoperative Complications; Rupture, Spontaneous; Sulfonamides; Suture Techniques; Thrombocytopenia; Thromboembolism | 2005 |
Argatroban and renal replacement therapy in patients with heparin-induced thrombocytopenia.
Topics: Adult; Aged; Aged, 80 and over; Arginine; Female; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Prospective Studies; Renal Replacement Therapy; Sulfonamides; Thrombocytopenia | 2005 |
Systemic administration of argatroban reduces secondary brain damage in a rat model of intracerebral hemorrhage: histopathological assessment.
Topics: Animals; Anticoagulants; Arginine; Astrocytes; Brain Edema; Cerebral Hemorrhage; Hematoma; Male; Neutrophils; Pipecolic Acids; Rats; Rats, Wistar; Sulfonamides | 2005 |
Argatroban treatment for patients with intolerance to heparin and hirudin.
Topics: Adolescent; Adult; Aged; Arginine; Contraindications; Drug Hypersensitivity; Female; Heparin; Hirudins; Humans; Middle Aged; Pipecolic Acids; Sulfonamides | 2005 |
Direct thrombin inhibitors in heparin-induced thrombocytopenia.
Topics: Antithrombins; Arginine; Clinical Trials as Topic; Drug Therapy, Combination; Humans; International Normalized Ratio; Pipecolic Acids; Sulfonamides; Thrombocytopenia | 2005 |
Antithrombotic potential of new direct thrombin inhibitors built on the azaphenylalanine scaffold in two rat venous thrombosis models.
Topics: Administration, Oral; Animals; Anticoagulants; Arginine; Blood Coagulation Tests; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Fibrinolytic Agents; Injections, Subcutaneous; Male; Nadroparin; Phenylalanine; Pipecolic Acids; Rats; Rats, Wistar; Structure-Activity Relationship; Sulfonamides; Thrombin; Thrombophilia; Vena Cava, Inferior; Venous Thrombosis | 2005 |
Argatroban anticoagulation in conjunction with glycoprotein IIb/IIIa inhibition in patients undergoing percutaneous coronary intervention: an open-label, nonrandomized pilot study.
Topics: Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Arginine; Coronary Disease; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Pilot Projects; Pipecolic Acids; Platelet Glycoprotein GPIIb-IIIa Complex; Sulfonamides | 2004 |
The use of argatroban for carotid endarterectomy in heparin-induced thrombocytopenia.
Topics: Aged; Anticoagulants; Aortic Aneurysm, Abdominal; Arginine; Blood Coagulation Tests; Endarterectomy, Carotid; Female; Heparin; Humans; Pipecolic Acids; Sulfonamides; Thrombocytopenia | 2005 |
Argatroban for anticoagulation during cardiopulmonary bypass in an infant.
Topics: Anti-Bacterial Agents; Antibodies; Anticoagulants; Arginine; Cardiopulmonary Bypass; Drug Hypersensitivity; Endocarditis, Bacterial; Heparin; Hepatomegaly; Humans; Infant; Intraoperative Complications; Male; Pipecolic Acids; Splenomegaly; Sulfonamides; Thrombocytopenia; Tricuspid Valve | 2005 |
Argatroban-coupled Affi-Gel matrix for the purification of thrombin from plasma.
Topics: Animals; Arginine; Elapidae; Electrophoresis, Polyacrylamide Gel; Gels; Pipecolic Acids; Plasma; Sulfonamides; Thrombin | 2005 |
Carotid tissue levels of argatroban after direct local delivery during carotid endarterectomy to prevent perioperative cerebral embolism.
Topics: Adult; Aged; Arginine; Carotid Arteries; Carotid Stenosis; Endarterectomy, Carotid; Female; Humans; Intracranial Embolism; Intraoperative Period; Male; Middle Aged; Pipecolic Acids; Platelet Aggregation Inhibitors; Retrospective Studies; Sulfonamides; Tissue Distribution | 2005 |
Effect of argatroban on the activated partial thromboplastin time: a comparison of 21 commercial reagents.
Topics: Arginine; Blood Coagulation; Dose-Response Relationship, Drug; Drug Monitoring; Heparin; Humans; Partial Thromboplastin Time; Pipecolic Acids; Reagent Kits, Diagnostic; Sensitivity and Specificity; Sulfonamides; Thrombocytopenia | 2005 |
Extensive prolongation of aPTT with argatroban in an elderly patient with improving renal function, normal hepatic enzymes, and metastatic lung cancer.
Topics: Aged; Anticoagulants; Arginine; Humans; Infusions, Intravenous; Kidney; Kidney Function Tests; Liver; Liver Function Tests; Lung Neoplasms; Male; Partial Thromboplastin Time; Pipecolic Acids; Sulfonamides; Time Factors; Venous Thrombosis | 2005 |
Coagulation management of a patient with factor V Leiden mutation, lupus anticoagulant, and activated protein C resistance: a case report.
Topics: Activated Protein C Resistance; Adult; Anticoagulants; Arginine; Coronary Stenosis; Factor V; Female; Heparin, Low-Molecular-Weight; Humans; Intraoperative Care; Lupus Coagulation Inhibitor; Pipecolic Acids; Postoperative Care; Sulfonamides; Thrombocytopenia | 2005 |
No increase in rejection or graft loss in kidney transplant recipients with thrombophilia treated with anticoagulation and triple immunosuppression.
Topics: Anticoagulants; Arginine; Creatinine; Drug Therapy, Combination; Factor V; Female; Graft Rejection; Graft Survival; Heparin; Histocompatibility Testing; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Mutation; Pipecolic Acids; Sulfonamides; Thrombophilia; Thrombosis | 2005 |
The role of thrombin in gliomas.
Topics: Animals; Arginine; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Glioma; Humans; Male; Motor Activity; Pipecolic Acids; Rats; Rats, Inbred F344; Sulfonamides; Survival Rate; Thrombin; Tumor Burden | 2005 |
Treatment of patients with a history of heparin-induced thrombocytopenia and anti-lepirudin antibodies with argatroban.
Topics: Aged; Antibodies; Anticoagulants; Arginine; Enzyme-Linked Immunosorbent Assay; Female; Heparin; Hirudin Therapy; Hirudins; Humans; Immunoglobulin G; Male; Middle Aged; Pipecolic Acids; Platelet Aggregation Inhibitors; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2005 |
Scanning electron microscopical observations of two novel hemostatic polymers.
Topics: Aluminum; Anticoagulants; Arginine; Calcium Chloride; Citric Acid; Hemostasis; Hemostatics; Humans; Microscopy, Electron, Scanning; Pipecolic Acids; Polymers; Sulfonamides; Time Factors | 2005 |
Thrombin inhibitor reduces leukocyte-endothelial cell interactions and vascular leakage after scatter laser photocoagulation.
Topics: Animals; Anticoagulants; Arginine; Blood-Retinal Barrier; Capillary Permeability; Cell Adhesion; Dextrans; Endothelium, Vascular; Fluorescein-5-isothiocyanate; Intercellular Adhesion Molecule-1; Laser Coagulation; Leukocytes; Macular Edema; Male; P-Selectin; Pipecolic Acids; Rats; Rats, Long-Evans; Retina; Retinal Vessels; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Thrombin | 2005 |
Toxicity of argatroban overdose in a 65-year-old man.
Topics: Aged; Arginine; Drug Overdose; Heart Valve Diseases; Humans; Male; Medical Errors; Pipecolic Acids; Sulfonamides; Thrombocytopenia | 2005 |
Successful therapy with argatroban for superior mesenteric vein thrombosis in a patient with congenital antithrombin deficiency.
Topics: Adult; Antithrombin III Deficiency; Arginine; DNA Mutational Analysis; Female; Frameshift Mutation; Heterozygote; Humans; Mesenteric Vascular Occlusion; Mesenteric Veins; Pipecolic Acids; Salvage Therapy; Sulfonamides; Treatment Outcome; Venous Thrombosis | 2005 |
Mechanism of antithrombotic effect of heparin and antithrombin in balloon-injured arteries.
Topics: Angiography; Animals; Antithrombins; Arginine; Arteries; Catheterization; Dogs; Fibrinogen; Fibrinolytic Agents; Heparin; Iliac Artery; Microscopy, Fluorescence; Partial Thromboplastin Time; Pipecolic Acids; Prothrombin Time; Sulfonamides; Thrombosis | 2005 |
Collaborative study on monitoring methods to determine direct thrombin inhibitors lepirudin and argatroban.
Topics: Arginine; Blood Coagulation Tests; Cooperative Behavior; Drug Monitoring; Enzyme-Linked Immunosorbent Assay; Fibrinolytic Agents; Hirudins; Humans; Methods; Pipecolic Acids; Recombinant Proteins; Reproducibility of Results; Sulfonamides; Thrombin | 2005 |
The paradox of heparin-induced thrombocytopenia: the initial management.
Topics: Anticoagulants; Arginine; Heparin; Hirudins; Humans; Pipecolic Acids; Platelet Aggregation Inhibitors; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2005 |
Acute subdural hematoma: new model delineation and effects of coagulation inhibitors.
Topics: Animals; Anticoagulants; Arginine; Behavior, Animal; Disease Models, Animal; Diterpenes; Extremities; Fibrinolytic Agents; Ginkgolides; Hematoma, Subdural, Acute; Lactones; Male; Movement; Pipecolic Acids; Psychomotor Performance; Rats; Reproducibility of Results; Sulfonamides; Time Factors | 2005 |
Presence of direct thrombin inhibitors can affect the results and interpretation of lupus anticoagulant testing.
Topics: Anticoagulants; Arginine; Blood Coagulation; Blood Coagulation Tests; Dose-Response Relationship, Drug; Heparin; Hirudins; Humans; In Vitro Techniques; Lupus Coagulation Inhibitor; Partial Thromboplastin Time; Peptide Fragments; Pipecolic Acids; Prothrombin Time; Recombinant Proteins; Reference Values; Sulfonamides; Viper Venoms | 2005 |
Direct thrombin inhibitors.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Antithrombins; Arginine; Benzimidazoles; Blood Coagulation; Dabigatran; Heart Diseases; Heparin; Humans; Pipecolic Acids; Prodrugs; Pyridines; Sulfonamides; Thrombin; Thromboembolism; Thrombosis; Venous Thrombosis | 2005 |
Direct thrombin inhibitors are not equally effective in vivo against arterial thrombosis: in vivo evaluation of DuP714 and argatroban in a porcine angioplasty model and comparison to r-hirudin.
Topics: Angioplasty, Balloon; Animals; Anticoagulants; Arginine; Boron Compounds; Drug Evaluation, Preclinical; Hirudins; Oligopeptides; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Swine; Thrombin; Thrombosis | 2005 |
Argatroban and lepirudin requirements in a 6-year-old patient with heparin-induced thrombocytopenia.
Topics: Anticoagulants; Arginine; Child; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Female; Heparin; Hirudins; Humans; Partial Thromboplastin Time; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2005 |
Comment: extensive prolongation of aPTT with argatroban in an elderly patient with improving renal function, normal hepatic enzymes, and metastatic lung cancer.
Topics: Aged; Anticoagulants; Arginine; Humans; International Normalized Ratio; Kidney; Kidney Function Tests; Liver; Lung Neoplasms; Partial Thromboplastin Time; Pipecolic Acids; Sulfonamides; Venous Thrombosis; Warfarin | 2005 |
Argatroban and lepirudin: clinical trials to clinical practice.
Topics: Anticoagulants; Arginine; Clinical Trials as Topic; Hirudins; Humans; Pipecolic Acids; Recombinant Proteins; Sulfonamides | 2005 |
A comparison of lepirudin and argatroban outcomes.
Topics: Aged; Anticoagulants; Arginine; Female; Hemorrhage; Hirudins; Humans; Male; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombin; Treatment Outcome | 2005 |
Inhibition of thrombin-induced vascular endothelial growth factor production in human neuroblastoma (NB-1) cells by argatroban.
Topics: Animals; Arginine; Calcium; Calcium Signaling; Enzyme Inhibitors; Hemostatics; Humans; Neuroblastoma; PC12 Cells; Phosphatidylinositol 3-Kinases; Pipecolic Acids; Platelet Aggregation Inhibitors; Protein Kinase C; Rats; Sulfonamides; Thrombin; Vascular Endothelial Growth Factor A | 2005 |
Evaluation of diagnostic tests and argatroban or lepirudin therapy in patients with suspected heparin-induced thrombocytopenia.
Topics: Anticoagulants; Arginine; Cohort Studies; Female; Heparin; Hirudins; Humans; Male; Middle Aged; Partial Thromboplastin Time; Pipecolic Acids; Platelet Activation; Platelet Aggregation; Recombinant Proteins; Retrospective Studies; Sulfonamides; Thrombocytopenia | 2005 |
Heparin-induced thrombocytopenia from venous thromboembolism treatment.
Topics: Amputation, Surgical; Anticoagulants; Arginine; Drug Administration Schedule; Female; Hemorrhage; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Platelet Count; Randomized Controlled Trials as Topic; Recurrence; Retrospective Studies; Sulfonamides; Thrombocytopenia; Thromboembolism; Treatment Outcome; Warfarin | 2005 |
[A case of anterior cerebral artery dissection causing enlargement of infarction].
Topics: Anterior Cerebral Artery; Aortic Dissection; Arginine; Aspirin; Diffusion Magnetic Resonance Imaging; Female; Fibrinolytic Agents; Humans; Infarction, Anterior Cerebral Artery; Magnetic Resonance Angiography; Middle Aged; Pipecolic Acids; Sulfonamides | 2005 |
Thrombin-induced delayed injury involves multiple and distinct signaling pathways in the cerebral cortex and the striatum in organotypic slice cultures.
Topics: Animals; Anticoagulants; Apoptosis; Arginine; Brain Damage, Chronic; Caspase 3; Caspase Inhibitors; Caspases; Cerebral Cortex; Cerebral Hemorrhage; Corpus Striatum; MAP Kinase Signaling System; Nerve Degeneration; Organ Culture Techniques; Oxidative Stress; Phosphorylation; Pipecolic Acids; Protein Kinase C; Protein Synthesis Inhibitors; Rats; Rats, Wistar; Receptor, PAR-1; src-Family Kinases; Sulfonamides; Thrombin; Time Factors | 2006 |
Cardiopulmonary bypass using argatroban as an anticoagulant for a 6.0-kg pediatric patient.
Topics: Anticoagulants; Arginine; Cardiopulmonary Bypass; Extracorporeal Membrane Oxygenation; Heart Defects, Congenital; Humans; Infant; Pipecolic Acids; Sulfonamides; Thrombosis | 2005 |
Differences in the clinically effective molar concentrations of four direct thrombin inhibitors explain their variable prothrombin time prolongation.
Topics: Animals; Anticoagulants; Arginine; Azetidines; Benzylamines; Blood Coagulation; Cattle; Dose-Response Relationship, Drug; Factor Xa; Factor Xa Inhibitors; Glycine; Hirudins; Humans; In Vitro Techniques; Partial Thromboplastin Time; Peptide Fragments; Pipecolic Acids; Prothrombin Time; Recombinant Proteins; Species Specificity; Sulfonamides; Thrombin; Thrombin Time; Thromboplastin | 2005 |
A new method for assessment of an anti-5HT(2A) agent, sarpogrelate hydrochloride, on platelet aggregation.
Topics: Arginine; Epinephrine; Humans; In Vitro Techniques; Pipecolic Acids; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Serotonin; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Succinates; Sulfonamides | 2006 |
Antithrombin reduces reperfusion-induced hepatic metastasis of colon cancer cells.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Antithrombins; Arginine; Cell Line, Tumor; Colonic Neoplasms; E-Selectin; Epoprostenol; Fibrin Fibrinogen Degradation Products; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C57BL; Pipecolic Acids; Rats; Rats, Inbred F344; Reperfusion; RNA, Messenger; Sulfonamides; Tumor Necrosis Factor-alpha | 2006 |
Successful recovery after an overdose of argatroban.
Topics: Aged; Anticoagulants; Arginine; Blood Component Transfusion; Drug Overdose; Humans; Male; Medication Errors; Pipecolic Acids; Plasma; Sulfonamides; Thrombin; Thrombocytopenia; Treatment Outcome | 2006 |
Systemic use of argatroban reduces tumor mass, attenuates neurological deficits and prolongs survival time in rat glioma models.
Topics: Animals; Anticoagulants; Antineoplastic Agents; Arginine; Brain; Brain Edema; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Glioma; Injections, Intraventricular; Male; Mental Disorders; Pipecolic Acids; Rats; Rats, Inbred F344; Sulfonamides; Survival Rate; Treatment Outcome | 2005 |
Heparin-induced thrombocytopenia in a pediatric patient receiving extracorporeal support and treated with argatroban.
Topics: Anticoagulants; Arginine; Extracorporeal Membrane Oxygenation; Heparin; Humans; Infant; Male; Pipecolic Acids; Renal Replacement Therapy; Sulfonamides; Thrombocytopenia | 2006 |
[A case of heparin-induced thrombocytopenia associated with unexpected excessive argatroban anticoagulation after abdominal aortic aneurysm resection].
Topics: Aged; Anticoagulants; Aortic Aneurysm, Abdominal; Arginine; Heparin; Humans; Intraoperative Complications; Male; Pipecolic Acids; Sulfonamides; Thrombocytopenia | 2006 |
Heparin-induced thrombocytopenia and cardiovascular patients: recognition and treatment.
Topics: Anticoagulants; Arginine; Heparin; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Platelet Factor 4; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2006 |
Evaluation of treatment with direct thrombin inhibitors in patients with heparin-induced thrombocytopenia.
Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Arginine; Female; Heparin; Hirudins; Humans; Male; Middle Aged; Partial Thromboplastin Time; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Retrospective Studies; Sulfonamides; Thrombin; Thrombocytopenia; Time Factors; Treatment Outcome | 2006 |
[Argatroban].
Topics: Anticoagulants; Arginine; Drug Monitoring; Humans; Pipecolic Acids; Sulfonamides; Thrombosis | 2006 |
Argatroban dosing of patients with heparin-induced thrombocytopenia and an elevated aPTT due to antiphospholipid antibody syndrome.
Topics: Adult; Anticoagulants; Antiphospholipid Syndrome; Arginine; Female; Fondaparinux; Heparin; Humans; Middle Aged; Partial Thromboplastin Time; Pipecolic Acids; Polysaccharides; Sulfonamides; Thrombocytopenia; Thrombosis | 2006 |
Inhibitors of blood coagulation factors Xa and IIa synergize to reduce thrombus weight and thrombin generation in vivo and in vitro.
Topics: Animals; Arginine; Bleeding Time; Factor Xa Inhibitors; Fibrinolytic Agents; Humans; In Vitro Techniques; Partial Thromboplastin Time; Pipecolic Acids; Piperidines; Platelet Aggregation Inhibitors; Prothrombin; Rabbits; Sulfonamides; Thrombin; Thrombosis | 2006 |
Argatroban therapy in heparin-induced thrombocytopenia with hepatic dysfunction.
Topics: Aged; Anticoagulants; Arginine; Bilirubin; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Heparin; Humans; Liver Diseases; Male; Middle Aged; Partial Thromboplastin Time; Pipecolic Acids; Platelet Aggregation Inhibitors; Retrospective Studies; Sulfonamides; Thrombocytopenia; Thrombosis; Treatment Outcome | 2006 |
Flavonoids inhibit the amidolytic activity of human thrombin.
Topics: Amidohydrolases; Arginine; Binding Sites; Binding, Competitive; Biosensing Techniques; Blood Coagulation; Enzyme Activation; Enzyme Stability; Flavonoids; Humans; Kinetics; Models, Molecular; Molecular Structure; Pipecolic Acids; Quantitative Structure-Activity Relationship; Sulfonamides; Thrombin | 2006 |
Argatroban, bivalirudin, and lepirudin do not decrease clot propagation and strength as effectively as heparin-activated antithrombin in vitro.
Topics: Anticoagulants; Antithrombins; Arginine; Cardiopulmonary Bypass; Child; Dose-Response Relationship, Drug; Fatal Outcome; Female; Fibrinolytic Agents; Heart Transplantation; Heparin; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Platelet Aggregation Inhibitors; Recombinant Proteins; Sulfonamides; Thrombelastography; Thrombocytopenia; Treatment Failure; Whole Blood Coagulation Time | 2006 |
Cardiac surgery in a patient with heparin-induced thrombocytopenia--cautions with use of the direct thrombin inhibitor, argatroban.
Topics: Aged, 80 and over; Anticoagulants; Aortic Valve Stenosis; Arginine; Contraindications; Coronary Artery Bypass; Female; Heparin; Humans; Pipecolic Acids; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Sulfonamides; Thrombocytopenia | 2006 |
Thrombotic end point for assessing argatroban therapy for heparin-induced thrombocytopenia: learning from secondary analyses of prospective studies.
Topics: Anticoagulants; Arginine; Cohort Studies; Heparin; Humans; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Thrombosis; Treatment Outcome | 2006 |
Effects of argatroban therapy, demographic variables, and platelet count on thrombotic risks in heparin-induced thrombocytopenia.
Topics: Aged; Amputation, Surgical; Anticoagulants; Arginine; Cohort Studies; Controlled Clinical Trials as Topic; Female; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Platelet Count; Retrospective Studies; Sulfonamides; Thrombocytopenia; Thrombosis; Treatment Outcome | 2006 |
On-chip titration of an anticoagulant argatroban and determination of the clotting time within whole blood or plasma using a plug-based microfluidic system.
Topics: Anticoagulants; Arginine; Humans; Microarray Analysis; Microfluidics; Pipecolic Acids; Plasma; Sulfonamides; Thrombin; Time Factors; Titrimetry | 2006 |
[Two cases of heparin-induced thrombocytopenia (HIT) and a review of the literature].
Topics: Aged; Antibodies; Arginine; Female; Heart Failure; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Platelet Factor 4; Pulmonary Embolism; Sulfonamides; Thrombocytopenia; Treatment Outcome; Warfarin | 2006 |
Heparin-induced thrombocytopenia in patients administered heparin solely for hemodialysis.
Topics: Adult; Aged; Amputation, Surgical; Anticoagulants; Arginine; Dose-Response Relationship, Drug; Female; Heparin; Humans; Male; Middle Aged; Partial Thromboplastin Time; Pipecolic Acids; Platelet Count; Registries; Renal Dialysis; Retrospective Studies; Sulfonamides; Thrombocytopenia; Thrombosis; Treatment Outcome | 2006 |
Systemic anticoagulation with argatroban during arteriovenous dialysis graft thrombolysis.
Topics: Anticoagulants; Arginine; Hemofiltration; Humans; Infusions, Intravenous; Kidney Failure, Chronic; Male; Middle Aged; Pipecolic Acids; Renal Dialysis; Sulfonamides; Thrombolytic Therapy; Thrombosis | 2006 |
Effect of renal function on argatroban therapy in heparin-induced thrombocytopenia.
Topics: Aged; Anticoagulants; Arginine; Cohort Studies; Creatinine; Dose-Response Relationship, Drug; Female; Heparin; Humans; Kidney Diseases; Kidney Function Tests; Male; Middle Aged; Partial Thromboplastin Time; Pipecolic Acids; Platelet Aggregation Inhibitors; Retrospective Studies; Sulfonamides; Thrombocytopenia | 2006 |
Prolonged anticoagulation after discontinuation of argatroban and warfarin therapy in an obese patient with heparin-induced thrombocytopenia.
Topics: Adult; Anticoagulants; Arginine; Drug Therapy, Combination; Female; Gastric Bypass; Heparin; Humans; International Normalized Ratio; Obesity, Morbid; Partial Thromboplastin Time; Pipecolic Acids; Pulmonary Embolism; Sulfonamides; Thrombocytopenia; Treatment Outcome; Warfarin | 2006 |
Assessing nonlinearity in compartment models via the relative curvature measure.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Arginine; Computer Simulation; Humans; Indomethacin; Models, Biological; Nonlinear Dynamics; Pipecolic Acids; Reproducibility of Results; Sulfonamides | 2007 |
Hydroxyethyl starch enhances argatroban-mediated decreases in clot propagation and strength by diminishing thrombin-fibrinogen interactions.
Topics: Anticoagulants; Arginine; Blood Coagulation; Cardiopulmonary Bypass; Drug Synergism; Fibrinogen; Hemostasis; Heparin; Humans; Hydroxyethyl Starch Derivatives; Pipecolic Acids; Protein Binding; Sulfonamides; Thrombin; Thrombocytopenia | 2007 |
[Two surgical case reports showing atypical heparin-induced thrombocytopenia].
Topics: Adult; Anticoagulants; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Drug Eruptions; Female; Heparin; Heparin, Low-Molecular-Weight; Heparitin Sulfate; Hirudins; Humans; Male; Pipecolic Acids; Platelet Count; Platelet Factor 4; Postoperative Complications; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Thrombosis; Time Factors | 2007 |
Differential effects of direct thrombin inhibitors and antithrombin-dependent anticoagulants on the dynamics of clot formation.
Topics: Anticoagulants; Antithrombins; Arginine; Blood Coagulation; Drug Evaluation, Preclinical; Elasticity; Enoxaparin; Fondaparinux; Heparin; Hirudins; Humans; Kinetics; Peptide Fragments; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Stress, Mechanical; Sulfonamides; Thrombelastography; Thrombin | 2007 |
[Bilateral cerebellar infarction caused by intracranial dissection of the vertebral artery after long periods of "Shiatsu"].
Topics: Acupressure; Acute Disease; Angiography; Anticoagulants; Arginine; Cerebellum; Cerebral Infarction; Diffusion Magnetic Resonance Imaging; Female; Humans; Infusions, Intravenous; Middle Aged; Pipecolic Acids; Sulfonamides; Tomography, X-Ray Computed; Vertebral Artery Dissection; Warfarin | 2007 |
Development of self-expandable covered stents.
Topics: Alloys; Angiography; Animals; Anticoagulants; Arginine; Blood Vessel Prosthesis; Coated Materials, Biocompatible; Dogs; Drug Implants; Elasticity; Immunosuppressive Agents; Pipecolic Acids; Prosthesis Design; Stents; Sulfonamides; Tacrolimus | 2007 |
Impact of smart infusion technology on administration of anticoagulants (unfractionated Heparin, Argatroban, Lepirudin, and Bivalirudin).
Topics: Anticoagulants; Arginine; Boston; Drug Overdose; Drug Therapy, Computer-Assisted; Heparin; Hirudins; Humans; Infusion Pumps; Infusions, Intravenous; Medication Errors; Medication Systems, Hospital; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Research Design; Sulfonamides | 2007 |
Argatroban for anticoagulation in pediatric patients with heparin-induced thrombocytopenia requiring extracorporeal life support.
Topics: Anticoagulants; Arginine; Extracorporeal Circulation; Female; Fibrinolytic Agents; Heparin; Humans; Infant; Infant, Newborn; Pipecolic Acids; Sulfonamides; Thrombocytopenia | 2007 |
Efficacy of anti-coagulant treatment with argatroban on cardioembolic stroke.
Topics: Aged; Aged, 80 and over; Anticoagulants; Arginine; Cohort Studies; Female; Heparin; Humans; Japan; Male; Pipecolic Acids; Registries; Regression Analysis; Retrospective Studies; Severity of Illness Index; Stroke; Sulfonamides | 2007 |
Argatroban anticoagulation for renal replacement therapy in patients with heparin-induced thrombocytopenia after cardiovascular surgery.
Topics: Acute Kidney Injury; Anticoagulants; Arginine; Cardiovascular Surgical Procedures; Female; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Renal Replacement Therapy; Sulfonamides; Thrombocytopenia | 2007 |
Involvement of thrombin and mitogen-activated protein kinase pathways in hemorrhagic brain injury.
Topics: Animals; Arginine; Brain; Brain Damage, Chronic; Cell Death; Cerebral Hemorrhage; Cycloheximide; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Gliosis; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Kinase 1; MAP Kinase Signaling System; Microglia; Nerve Degeneration; Neurons; Neuroprotective Agents; Pipecolic Acids; Platelet Aggregation Inhibitors; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Sulfonamides; Thrombin | 2007 |
Argatroban anticoagulation in obese versus nonobese patients: implications for treating heparin-induced thrombocytopenia.
Topics: Anticoagulants; Arginine; Body Weight; Female; Heparin; Humans; Male; Obesity; Partial Thromboplastin Time; Pipecolic Acids; Platelet Count; Retrospective Studies; Sulfonamides; Thrombocytopenia; Treatment Outcome | 2007 |
Effect of body mass index on Argatroban therapy during percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Arginine; Blood Coagulation; Body Mass Index; Coronary Artery Disease; Female; Hemorrhage; Heparin; Humans; Male; Middle Aged; Obesity; Pipecolic Acids; Retrospective Studies; Sulfonamides; Thrombocytopenia | 2008 |
Argatroban in extracorporeal membrane oxygenation.
Topics: Adult; Anticoagulants; Arginine; Extracorporeal Membrane Oxygenation; Female; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Respiratory Distress Syndrome; Sulfonamides; Thrombocytopenia | 2007 |
Efficacy and safety of argatroban with or without glycoprotein IIb/IIIa inhibitor in patients with heparin induced thrombocytopenia undergoing percutaneous coronary intervention for acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Anticoagulants; Arginine; Drug Therapy, Combination; Female; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Platelet Glycoprotein GPIIb-IIIa Complex; Retrospective Studies; Sulfonamides; Thrombocytopenia | 2008 |
Heparin-induced thrombocytopenia II-induced critical limb ischaemia treated with urokinase and argatroban.
Topics: Aged; Arginine; Blood Coagulation Tests; Extremities; Heparin; Humans; Ischemia; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Thrombolytic Therapy; Urokinase-Type Plasminogen Activator | 2007 |
Influence of argatroban on coagulation parameters in heparin-induced thrombocytopenia patients after cardiothoracic surgery.
Topics: Aged; Anticoagulants; Arginine; Blood Coagulation; Coronary Artery Bypass; Female; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Sulfonamides; Thrombocytopenia | 2007 |
Argatroban therapy in patients with coronary artery disease and heparin-induced thrombocytopenia.
Topics: Aged; Amputation, Surgical; Anticoagulants; Arginine; Case-Control Studies; Cause of Death; Coronary Artery Disease; Female; Heparin; Humans; Male; Pipecolic Acids; Prospective Studies; Statistics, Nonparametric; Sulfonamides; Thrombocytopenia; Treatment Outcome | 2008 |
Visual evaluation of blood coagulation during mural thrombogenesis under high shear blood flow.
Topics: Adult; Anticoagulants; Arginine; Blood Coagulation; Blood Flow Velocity; Blood Platelets; Collagen; Dose-Response Relationship, Drug; Factor VIIa; Fibrin; Hemolysis; Hemophilia A; Hemorheology; Heparin; Humans; Male; Microscopy, Confocal; Microscopy, Electron, Scanning; Middle Aged; Perfusion; Pipecolic Acids; Sulfonamides; Surface Properties; Thrombosis | 2008 |
Seizures, headache and thrombocytopenia: diagnosis and treatment do not always come in a standard sequence.
Topics: Arginine; Female; Headache; Heparin, Low-Molecular-Weight; Hirudins; Humans; Middle Aged; Pipecolic Acids; Recombinant Proteins; Seizures; Sulfonamides; Thrombocytopenia | 2007 |
Prolonged half-life of argatroban in patients with renal dysfunction and antiphospholipid antibody syndrome being treated for heparin-induced thrombocytopenia.
Topics: Anticoagulants; Antiphospholipid Syndrome; Arginine; Cholangiopancreatography, Endoscopic Retrograde; Female; Half-Life; Heparin; Humans; Kidney Failure, Chronic; Lupus Erythematosus, Systemic; Middle Aged; Peritoneal Dialysis; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Treatment Outcome; Warfarin | 2008 |
A case of heparin-induced thrombocytopenia with repeated episodes of acute lower extremity arterial thromboembolism during a short time.
Topics: Anticoagulants; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Female; Heparin; Heparitin Sulfate; Humans; Leg; Middle Aged; Pipecolic Acids; Recurrence; Sulfonamides; Thrombectomy; Thrombocytopenia; Thromboembolism | 2007 |
Inhibition of thrombin generation in recalcified plasma.
Topics: Anticoagulants; Aprotinin; Arginine; Blood Coagulation Tests; Chondroitin Sulfates; Dermatan Sulfate; Fondaparinux; Heparin; Heparitin Sulfate; Hirudins; Humans; Pipecolic Acids; Plant Proteins; Plasma; Polysaccharides; Sulfonamides; Thrombin | 2007 |
Catheter-directed thrombolysis of acute lower extremity arterial thrombosis in a patient with heparin-induced thrombocytopenia.
Topics: Aged; Anticoagulants; Arginine; Arterial Occlusive Diseases; Catheterization, Peripheral; Fibrinolytic Agents; Heparin; Humans; Infusions, Intra-Arterial; Lower Extremity; Male; Pipecolic Acids; Radiography; Sulfonamides; Thrombocytopenia; Thrombolytic Therapy; Thrombosis; Tissue Plasminogen Activator; Treatment Outcome | 2007 |
The thrombin inhibitor Argatroban reduces breast cancer malignancy and metastasis via osteopontin-dependent and osteopontin-independent mechanisms.
Topics: Animals; Anticoagulants; Arginine; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Female; Humans; Mammary Neoplasms, Animal; Mice; Neoplasm Metastasis; Osteopontin; Pipecolic Acids; Platelet Aggregation Inhibitors; Receptors, Thrombin; Sulfonamides; Thrombin | 2008 |
Complete 1H and 13C assignments of (21R) and (21S) diastereomers of argatroban.
Topics: Arginine; Carbon Isotopes; Fibrinolytic Agents; Hydrogen; Magnetic Resonance Spectroscopy; Molecular Structure; Pipecolic Acids; Stereoisomerism; Sulfonamides | 2008 |
Management of uremic patients with heparin-induced thrombocytopenia requiring hemodialysis.
Topics: Aged; Aged, 80 and over; Anticoagulants; Arginine; Benzamidines; Female; Guanidines; Heparin; Humans; Male; Middle Aged; Peritoneal Dialysis; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Uremia | 2008 |
Heparin-induced thrombocytopenia complicating hemodialysis.
Topics: Adult; Anticoagulants; Arginine; Calciphylaxis; Drug Contamination; Female; Heparin; Humans; Necrosis; Pipecolic Acids; Renal Dialysis; Renal Insufficiency; Skin Diseases; Sulfonamides; Thrombocytopenia; Warfarin | 2008 |
Thrombelastography in a patient with heparin-induced thrombocytopenia treated with argatroban.
Topics: Adult; Anticoagulants; Arginine; Blood Coagulation; Heparin; Humans; Male; Partial Thromboplastin Time; Pipecolic Acids; Prothrombin Time; Sulfonamides; Thrombelastography; Thrombocytopenia; Time Factors | 2008 |
[Patient with heparin-induced thrombocytopenia type II and implanted left ventricular assist device].
Topics: Aged; Anticoagulants; Arginine; Female; Heart-Assist Devices; Heparin; Humans; Partial Thromboplastin Time; Pipecolic Acids; Platelet Aggregation Inhibitors; Platelet Factor 4; Sulfonamides; Thrombocytopenia | 2008 |
Fondaparinux versus direct thrombin inhibitor therapy for the management of heparin-induced thrombocytopenia (HIT)--bridging the River Coumarin.
Topics: Acute Disease; Anticoagulants; Arginine; Blood Coagulation; Factor Xa Inhibitors; Fondaparinux; Hemorrhage; Heparin; Hirudins; Humans; International Normalized Ratio; Pipecolic Acids; Platelet Count; Polysaccharides; Recombinant Proteins; Research Design; Sulfonamides; Thrombin; Thrombocytopenia; Treatment Outcome; Venous Thrombosis; Warfarin | 2008 |
Standardizing the management of heparin-induced thrombocytopenia.
Topics: Anticoagulants; Arginine; Clinical Protocols; Evidence-Based Medicine; Fondaparinux; Heparin; Hirudins; Humans; Pipecolic Acids; Platelet Count; Platelet Function Tests; Polysaccharides; Recombinant Proteins; Retrospective Studies; Sulfonamides; Thrombocytopenia | 2008 |
[Are new anticoagulants better?].
Topics: Anticoagulants; Arginine; Drugs, Investigational; Factor Xa Inhibitors; Heparin; Humans; Pipecolic Acids; Sulfonamides; Thrombin; Thrombosis; Warfarin | 2007 |
Influence of continuous veno-venous hemofiltration on argatroban clearance in a patient with septic shock.
Topics: Anticoagulants; Arginine; Fatal Outcome; Female; Hemofiltration; Heparin; Humans; Middle Aged; Multiple Organ Failure; Pipecolic Acids; Shock, Septic; Sulfonamides; Thrombocytopenia | 2008 |
Reduced argatroban doses after coronary artery bypass graft surgery.
Topics: Aged; Aged, 80 and over; Arginine; Coronary Artery Bypass; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Pipecolic Acids; Postoperative Complications; Retrospective Studies; Sulfonamides; Thrombocytopenia | 2008 |
Considerations for drug dosing post coronary artery bypass graft surgery.
Topics: Anticoagulants; Arginine; Coronary Artery Bypass; Dose-Response Relationship, Drug; Humans; Pipecolic Acids; Sulfonamides | 2008 |
Argatroban therapy in patients with hepatic and renal impairment.
Topics: Acute Kidney Injury; Adult; Aged; Anticoagulants; Arginine; Critical Care; Critical Illness; Dose-Response Relationship, Drug; Female; Humans; Liver Diseases; Male; Pipecolic Acids; Postoperative Complications; Sulfonamides | 2008 |
[Heparin induced thrombocytopenia and anticoagulation in renal replacemant therapy].
Topics: Acute Kidney Injury; Anticoagulants; Arginine; Blood Coagulation Tests; Chondroitin Sulfates; Citrates; Critical Care; Dermatan Sulfate; Diagnostic Errors; Dose-Response Relationship, Drug; Epoprostenol; Fondaparinux; Hemofiltration; Heparin; Heparin, Low-Molecular-Weight; Heparitin Sulfate; Hirudins; Humans; Iloprost; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Sodium Citrate; Sulfonamides; Thrombocytopenia; Thrombosis | 2008 |
Comparison of the ecarin chromogenic assay and different aPTT assays for the measurement of argatroban concentrations in plasma from healthy individuals and from coagulation factor deficient patients.
Topics: Anticoagulants; Arginine; Coagulation Protein Disorders; Endopeptidases; Humans; Partial Thromboplastin Time; Pipecolic Acids; Quality Control; Sulfonamides | 2008 |
Argatroban as a primary or secondary postoperative anticoagulant in patients implanted with ventricular assist devices.
Topics: Anticoagulants; Arginine; Autoantibodies; Dose-Response Relationship, Drug; Drug Therapy, Combination; Follow-Up Studies; Heart Transplantation; Heart-Assist Devices; Heparin; Humans; Kruppel-Like Transcription Factors; Partial Thromboplastin Time; Pipecolic Acids; Postoperative Care; Postoperative Complications; Prosthesis Design; Repressor Proteins; Retrospective Studies; Sulfonamides; Survival Rate; Thrombin; Thrombocytopenia | 2008 |
Argatroban as a primary or secondary postoperative anticoagulant in patients implanted with ventricular assist devices. Invited commentary.
Topics: Anticoagulants; Arginine; Autoantibodies; Dose-Response Relationship, Drug; Drug Therapy, Combination; Heart-Assist Devices; Heparin; Humans; Infusions, Intravenous; Kruppel-Like Transcription Factors; Pipecolic Acids; Postoperative Complications; Postoperative Hemorrhage; Prosthesis Design; Repressor Proteins; Retrospective Studies; Risk Factors; Sulfonamides; Thrombin; Thrombocytopenia | 2008 |
Influence of direct thrombin inhibitor argatroban on coagulation assays in healthy individuals, patients under oral anticoagulation therapy and patients with liver dysfunction.
Topics: Anticoagulants; Arginine; Blood Coagulation; Blood Coagulation Factors; Blood Coagulation Tests; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Humans; In Vitro Techniques; Liver Diseases; Pipecolic Acids; Platelet Aggregation Inhibitors; Sulfonamides | 2008 |
Prediction of the therapeutic index of marketed anti-coagulants and anti-platelet agents by guinea pig models of thrombosis and hemostasis.
Topics: Animals; Anticoagulants; Arginine; Arteriovenous Shunt, Surgical; Aspirin; Bleeding Time; Chlorides; Ferric Compounds; Guinea Pigs; Hemostasis; Male; Pipecolic Acids; Platelet Aggregation Inhibitors; Sulfonamides; Thrombosis; Tirofiban; Tyrosine | 2008 |
Inhibition of osteopontin dependent carcinogenesis.
Topics: Alkaloids; Antineoplastic Agents; Arginine; Humans; Neoplasms; Osteopontin; Oxazolidinones; Pipecolic Acids; Selenium; Sulfonamides | 2008 |
Efficacy and safety of argatroban in patients with heparin induced thrombocytopenia undergoing endovascular intervention for peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Angioplasty; Anticoagulants; Arginine; Female; Heparin; Humans; Male; Middle Aged; Peripheral Vascular Diseases; Pipecolic Acids; Retrospective Studies; Sulfonamides; Thrombocytopenia; Treatment Outcome | 2008 |
Parenteral anticoagulants: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).
Topics: Anticoagulants; Arginine; Biological Availability; Chondroitin Sulfates; Dermatan Sulfate; Fondaparinux; Heparin; Heparin, Low-Molecular-Weight; Heparitin Sulfate; Hirudins; Humans; Infusions, Parenteral; Injections, Subcutaneous; Peptide Fragments; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2008 |
Transition from argatroban to oral anticoagulation with phenprocoumon or acenocoumarol: effect on coagulation factor testing.
Topics: Acenocoumarol; Administration, Oral; Adult; Anticoagulants; Arginine; Blood Coagulation Factors; Blood Coagulation Tests; Humans; Infusions, Intravenous; International Normalized Ratio; Male; Phenprocoumon; Pipecolic Acids; Sulfonamides; Thrombin; Vitamin K | 2008 |
What is the optimal anticoagulation level with argatroban during percutaneous coronary intervention?
Topics: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Anticoagulants; Arginine; Female; Heart Diseases; Hemorrhage; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Retrospective Studies; Sulfonamides; Thrombocytopenia; Whole Blood Coagulation Time | 2008 |
Interaction between thrombin mutant W215A/E217A and direct thrombin inhibitor.
Topics: Amino Acid Substitution; Anticoagulants; Arginine; Enzyme Inhibitors; Fibrinogen; Humans; Mutation, Missense; Pipecolic Acids; Protein Binding; Protein C; Protein Structure, Tertiary; Sulfonamides; Thrombin | 2008 |
Thrombin enhances the production of monocyte chemoattractant protein-1 and macrophage inflammatory protein-2 in cultured rat glomerular epithelial cells.
Topics: Animals; Anticoagulants; Arginine; Cells, Cultured; Chemokine CCL2; Chemokine CXCL2; Glucocorticoids; Male; Pipecolic Acids; Podocytes; Prednisolone; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sulfonamides; Thrombin | 2008 |
Complete salvage of impending free flap failure in heparin induced thrombocytopenia by emergent institution of therapy with argatroban.
Topics: Anastomosis, Surgical; Anticoagulants; Arginine; Carcinoma, Squamous Cell; Female; Graft Rejection; Heparin; Humans; Middle Aged; Mouth Neoplasms; Pipecolic Acids; Reoperation; Salvage Therapy; Sulfonamides; Surgical Flaps; Thrombocytopenia; Thrombosis; Veins | 2008 |
Rivaroxaban--an oral, direct Factor Xa inhibitor--has potential for the management of patients with heparin-induced thrombocytopenia.
Topics: Analysis of Variance; Anticoagulants; Antithrombin III; Arginine; Autoantibodies; Enoxaparin; Flow Cytometry; Fondaparinux; Heparin, Low-Molecular-Weight; Humans; Morpholines; Pipecolic Acids; Platelet Activation; Platelet Aggregation; Platelet Factor 4; Polysaccharides; Rivaroxaban; Sulfonamides; Thiophenes; Thrombocytopenia | 2008 |
Argatroban in short-term percutaneous ventricular assist subsequent to heparin-induced thrombocytopenia.
Topics: Adult; Arginine; Fibrinolytic Agents; Heart-Assist Devices; Heparin; Humans; Male; Pipecolic Acids; Platelet Aggregation Inhibitors; Platelet Count; Sulfonamides; Thrombocytopenia | 2008 |
Therapeutic effect of argatroban on rheumatoid vasculitis with antiphosphatidylserine-prothrombin complex antibody.
Topics: Aged; Anticoagulants; Arginine; Arthritis, Rheumatoid; Autoantibodies; Female; Humans; Leg Ulcer; Phosphatidylserines; Pipecolic Acids; Prothrombin; Skin; Sulfonamides; Thrombin; Vasculitis | 2008 |
Treatment of intracardiac thrombi with argatroban.
Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Arginine; Female; Heart Diseases; Humans; Male; Middle Aged; Partial Thromboplastin Time; Pipecolic Acids; Platelet Aggregation Inhibitors; Sulfonamides; Thrombosis; Treatment Outcome; Whole Blood Coagulation Time | 2008 |
Parenteral anticoagulants: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th edition). Addendum.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Arginine; Guidelines as Topic; Humans; Infusions, Parenteral; Pipecolic Acids; Sulfonamides | 2008 |
Use of Argatroban for anticoagulation during cardiopulmonary bypass in a patient with heparin allergy.
Topics: Aged; Anticoagulants; Arginine; Cardiopulmonary Bypass; Contraindications; Drug Hypersensitivity; Heart Valve Prosthesis Implantation; Heparin; Humans; Intraoperative Care; Male; Mitral Valve Insufficiency; Pipecolic Acids; Sulfonamides; Treatment Outcome | 2008 |
Management of anticoagulation in patients with subacute heparin-induced thrombocytopenia scheduled for heart transplantation.
Topics: Adult; Anticoagulants; Arginine; Autoantibodies; Heart Failure; Heart Transplantation; Heparin; Hirudins; Humans; Male; Middle Aged; Pipecolic Acids; Platelet Factor 4; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2008 |
Heparin-induced thrombocytopenia (HIT) causing pulmonary emboli during coronary intervention.
Topics: Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Anticoagulants; Arginine; Combined Modality Therapy; Coronary Angiography; Coronary Stenosis; Disseminated Intravascular Coagulation; Embolectomy; Heparin; Humans; Male; Pipecolic Acids; Pulmonary Embolism; Sulfonamides; Thrombocytopenia; Tomography, X-Ray Computed; Vena Cava Filters | 2008 |
A comparison of direct thrombin inhibitors in the treatment of Heparin-Induced Thrombocytopenia: a single institution experience.
Topics: Aged; Anticoagulants; Arginine; Female; Heparin; Hirudins; Humans; Male; Middle Aged; Pipecolic Acids; Recombinant Proteins; Retrospective Studies; Sulfonamides; Thrombocytopenia | 2009 |
RapidTEG observation suggests activation of factor VII may overcome argatroban-induced coagulopathy.
Topics: Arginine; Blood Coagulation Disorders; Child; Factor VII; Female; Humans; Pipecolic Acids; Sulfonamides; Thrombelastography; Time Factors | 2009 |
Argatroban enhances fibrinolysis by differential inhibition of thrombin-mediated activation of thrombin activatable fibrinolysis inhibitor and factor XIII.
Topics: Anticoagulants; Arginine; Blood Coagulation; Carboxypeptidase B2; Factor XIII; Fibrinolysis; Heparin; Humans; Kaolin; Kinetics; Pipecolic Acids; Sulfonamides; Thrombelastography; Thrombin; Thromboplastin; Tissue Plasminogen Activator | 2008 |
Dosing patterns and outcomes in African American, Asian, and Hispanic patients with heparin-induced thrombocytopenia treated with argatroban.
Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Arginine; Asian; Black or African American; Female; Fibrinolytic Agents; Heparin; Hispanic or Latino; Humans; Male; Middle Aged; Pipecolic Acids; Prospective Studies; Retrospective Studies; Sulfonamides; Thrombocytopenia; Thrombosis | 2009 |
INR matters: a case on managing argatroban for bridging oral anticoagulation in a patient with heparin induced thrombocytopenia type II after mechanical heart valve replacement.
Topics: Aged; Anticoagulants; Aortic Valve; Arginine; Female; Heart Valve Prosthesis Implantation; Heparin; Humans; International Normalized Ratio; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Treatment Outcome | 2009 |
Argatroban for anticoagulation in continuous renal replacement therapy.
Topics: Acute Kidney Injury; Aged; Anticoagulants; Arginine; Critical Illness; Female; Heparin; Humans; Male; Pipecolic Acids; Prospective Studies; Renal Replacement Therapy; Sulfonamides; Thrombocytopenia | 2009 |
Risk factors for major bleeding in patients with heparin-induced thrombocytopenia treated with argatroban: a retrospective study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticoagulants; Arginine; Blood Coagulation; Drug Monitoring; Female; Hemorrhage; Heparin; Humans; Lung Diseases; Male; Middle Aged; Odds Ratio; Partial Thromboplastin Time; Pipecolic Acids; Retrospective Studies; Risk Assessment; Risk Factors; Sulfonamides; Thrombocytopenia; Thrombosis; Young Adult | 2008 |
Influence of antithrombin and argatroban on disseminated intravascular coagulation parameters in a patient with septic shock.
Topics: Aged; Anticoagulants; Antithrombins; Arginine; Blood Coagulation; Female; Humans; Pipecolic Acids; Shock, Septic; Sulfonamides; Thrombosis | 2009 |
[Three cases of small brain infarction in the lateral wall of the fourth ventricle presenting with paroxysmal positional vertigo and vomiting].
Topics: Aged; Arginine; Brain Infarction; Diagnosis, Differential; Female; Fourth Ventricle; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Pipecolic Acids; Sulfonamides; Vertigo; Vomiting | 2008 |
"Drug dosing in the intensive care unit: the critically ill are a special population too".
Topics: Anticoagulants; Arginine; Critical Illness; Heparin; Humans; Intensive Care Units; Pipecolic Acids; Renal Insufficiency; Renal Replacement Therapy; Sulfonamides; Thrombocytopenia | 2009 |
Effects of critical illness and organ failure on therapeutic argatroban dosage requirements in patients with suspected or confirmed heparin-induced thrombocytopenia.
Topics: Adult; Aged; Anticoagulants; Arginine; Cohort Studies; Critical Illness; Dose-Response Relationship, Drug; Female; Heparin; Humans; Male; Middle Aged; Multiple Organ Failure; Pipecolic Acids; Retrospective Studies; Sulfonamides; Thrombocytopenia | 2009 |
Weight-based argatroban dosing nomogram for treatment of heparin-induced thrombocytopenia.
Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Arginine; Body Weight; Dose-Response Relationship, Drug; Female; Heparin; Humans; Male; Middle Aged; Nomograms; Pipecolic Acids; Prospective Studies; Sulfonamides; Thrombocytopenia; Treatment Outcome | 2009 |
The effect of ex vivo anticoagulants on whole blood platelet aggregation.
Topics: Adenosine Diphosphate; Anticoagulants; Arachidonic Acid; Arginine; Azetidines; Benzylamines; Blood Platelets; Citric Acid; Collagen; Female; Heparin; Hirudins; Humans; Male; Peptide Fragments; Pipecolic Acids; Platelet Aggregation; Platelet Function Tests; Recombinant Proteins; Ristocetin; Sulfonamides; Time Factors | 2009 |
84-year-old woman with hemodialysis-associated shortness of breath.
Topics: Aged, 80 and over; Anticoagulants; Arginine; Autoantibodies; Dyspnea; Echocardiography; Female; Heparin; Humans; Hypotension; Hypoxia; Pipecolic Acids; Platelet Activation; Platelet Aggregation; Platelet Factor 4; Renal Dialysis; Sulfonamides; Thrombocytopenia | 2009 |
[Use of argatroban during cardiopulmonary bypass for atrial septal defect with heparin induced thrombocytopenia after introduction of dialysis].
Topics: Adult; Anticoagulants; Arginine; Cardiopulmonary Bypass; Female; Heart Septal Defects, Atrial; Heparin; Humans; Intraoperative Care; Pipecolic Acids; Renal Dialysis; Sulfonamides; Thrombocytopenia; Whole Blood Coagulation Time | 2009 |
Heparin-induced thrombocytopenia in two patients undergoing abdominal aortic aneurysm surgery.
Topics: Aged; Anticoagulants; Aortic Aneurysm, Abdominal; Arginine; Autoantibodies; Disseminated Intravascular Coagulation; Heparin; Humans; Male; Mesenteric Arteries; Pipecolic Acids; Platelet Factor 4; Postoperative Complications; Sulfonamides; Thrombocytopenia; Thrombosis | 2010 |
Anticoagulation with the direct thrombin inhibitor argatroban in patients presenting with acute coronary syndromes.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Anticoagulants; Arginine; Cardiac Catheterization; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Pipecolic Acids; Retrospective Studies; Risk Assessment; Sulfonamides; Thrombin; Treatment Outcome | 2009 |
Thrombin inhibition by argatroban ameliorates early brain injury and improves neurological outcomes after experimental subarachnoid hemorrhage in rats.
Topics: Animals; Anticoagulants; Arginine; Blood-Brain Barrier; Brain Edema; Cell Death; Disease Models, Animal; Male; Motor Activity; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Recovery of Function; Subarachnoid Hemorrhage; Sulfonamides; Thrombin | 2009 |
Argatroban and catheter-directed thrombolysis with alteplase for limb- and graft-threatening thromboses in a patient with a history of HIT.
Topics: Aged; Antibodies, Anticardiolipin; Anticoagulants; Arginine; Catheterization; Contraindications; Drug Therapy, Combination; Femoral Vein; Heparin; Humans; Iliac Vein; Infusions, Intravenous; Ischemia; Kidney; Kidney Transplantation; Male; Pipecolic Acids; Popliteal Vein; Postoperative Complications; Protein S Deficiency; Purpura, Thrombocytopenic, Idiopathic; Renal Veins; Sulfonamides; Thrombolytic Therapy; Thrombophilia; Tissue Plasminogen Activator; Vena Cava Filters; Venous Thrombosis; Warfarin | 2009 |
Comparison of activated clotting times obtained using Hemochron and Medtronic analysers in patients receiving anti-thrombin therapy during cardiac catheterisation.
Topics: Aged; Aged, 80 and over; Anticoagulants; Arginine; Blood Coagulation Tests; Cardiac Catheterization; Drug Monitoring; Factor Xa; Factor Xa Inhibitors; Female; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Point-of-Care Systems; Statistics as Topic; Sulfonamides | 2009 |
[Argatroban treatment of heparin-induced immune-mediated thrombocytopenia].
Topics: Anticoagulants; Arginine; Fibrinolytic Agents; Heparin; Humans; Pipecolic Acids; Platelet Aggregation Inhibitors; Sulfonamides; Thrombocytopenia | 2009 |
[Heparin-induced thrombocytopenia].
Topics: Anticoagulants; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Fibrinolytic Agents; Heparin; Heparitin Sulfate; Hirudins; Humans; Pipecolic Acids; Recombinant Proteins; Risk Factors; Sulfonamides; Thrombocytopenia | 2009 |
A report of outcomes after orthotopic liver transplant with allografts from heparin antibody-positive donors.
Topics: Algorithms; Antibodies; Anticoagulants; Arginine; Clinical Protocols; Female; Heparin; Humans; Liver Transplantation; Male; Middle Aged; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Thrombosis; Tissue Donors; Transplantation, Homologous; Young Adult | 2009 |
Thrombin generation by intimal tissue factor contributes to thrombus formation on macrophage-rich neointima but not normal intima of hyperlipidemic rabbits.
Topics: Angioplasty, Balloon; Animals; Arginine; Femoral Artery; Humans; Hyperlipidemias; Lipoproteins; Macrophages; Male; Pipecolic Acids; Rabbits; Sulfonamides; Thrombin; Thromboplastin; Thrombosis; Tunica Intima | 2009 |
Thrombin enhances glioma growth.
Topics: Animals; Anticoagulants; Arginine; Behavior, Animal; Brain Neoplasms; Bromodeoxyuridine; Cell Line, Tumor; Cell Proliferation; Enzyme-Linked Immunosorbent Assay; Functional Laterality; Glioma; Hemostatics; Male; Neoplasm Transplantation; Pipecolic Acids; Rats; Rats, Inbred F344; Sulfonamides; Tetrazolium Salts; Thiazoles; Thrombin; Time Factors | 2008 |
Argatroban for anticoagulation in continuous renal replacement therapy.
Topics: Acute Kidney Injury; Anticoagulants; Arginine; Humans; Pipecolic Acids; Renal Replacement Therapy; Sulfonamides | 2009 |
Stabilization of the E* form turns thrombin into an anticoagulant.
Topics: Anticoagulants; Arginine; Binding Sites; Crystallography, X-Ray; Enzyme Activation; Humans; Models, Molecular; Mutagenesis, Site-Directed; Mutant Proteins; Pipecolic Acids; Protein Binding; Protein C; Protein Conformation; Sulfonamides; Thrombin; Thrombomodulin | 2009 |
Argatroban and bivalirudin compared to unfractionated heparin in preventing thrombus formation on mechanical heart valves. Results of an in-vitro study.
Topics: Anticoagulants; Arginine; Diagnostic Techniques, Cardiovascular; Drug Therapy, Combination; Feasibility Studies; Heart Diseases; Heart-Assist Devices; Heparin; Hirudins; Humans; In Vitro Techniques; Infusion Pumps; Male; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombin; Thrombocytopenia; Thrombosis | 2009 |
Impact of renal function on argatroban therapy during percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Arginine; Clinical Trials as Topic; Female; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Renal Insufficiency; Retrospective Studies; Sulfonamides; Thrombocytopenia; Thrombosis; Treatment Outcome | 2010 |
Anticoagulation with argatroban in a parturient with heparin-induced thrombocytopenia.
Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthesia, Spinal; Anticoagulants; Arginine; Female; Fondaparinux; Heparin; Humans; Pipecolic Acids; Platelet Aggregation Inhibitors; Polysaccharides; Pregnancy; Sulfonamides; Thrombocytopenia | 2010 |
HeartMate II implantation in patients with heparin-induced thrombocytopenia type II.
Topics: Anticoagulants; Arginine; Cardiopulmonary Bypass; Drug Therapy, Combination; Heart-Assist Devices; Heparin; Humans; Iloprost; Length of Stay; Male; Middle Aged; Pipecolic Acids; Platelet Aggregation Inhibitors; Prosthesis Design; Prosthesis Implantation; Sulfonamides; Thrombocytopenia; Warfarin | 2009 |
Clinical investigation in ACS and PCI: shooting in the dark at a moving target.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Anticoagulants; Arginine; Evidence-Based Medicine; Hemorrhage; Humans; Myocardial Infarction; Myocardial Revascularization; Pipecolic Acids; Research Design; Risk Assessment; Sulfonamides; Thrombin; Treatment Outcome | 2009 |
[Clinical observation of heparin-induced thrombocytopenia].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticoagulants; Arginine; Female; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Platelet Count; Sulfonamides; Thrombocytopenia; Venous Thromboembolism; Young Adult | 2009 |
Argatroban dosage requirements and outcomes in intensive care versus non-intensive care patients.
Topics: Aged; Aged, 80 and over; Anticoagulants; Arginine; Critical Care; Dose-Response Relationship, Drug; Female; Heparin; Humans; Intensive Care Units; Male; Middle Aged; Partial Thromboplastin Time; Pipecolic Acids; Retrospective Studies; Sulfonamides; Thrombocytopenia; Thrombosis; Treatment Outcome | 2009 |
Anterior spinal artery as a collateral channel in patients with acute bilateral vertebral artery occlusions. Two case reports.
Topics: Acute Disease; Aged; Antipyrine; Arginine; Brain Stem; Cerebellum; Cerebral Revascularization; Cerebrovascular Circulation; Circle of Willis; Coma; Disease Progression; Edaravone; Free Radical Scavengers; Functional Laterality; Humans; Male; Middle Aged; Pipecolic Acids; Platelet Aggregation Inhibitors; Recovery of Function; Respiratory Insufficiency; Sulfonamides; Treatment Outcome; Vertebral Artery; Vertebrobasilar Insufficiency | 2009 |
An evaluation of monitoring possibilities of argatroban using rotational thromboelastometry and activated partial thromboplastin time.
Topics: Arginine; Blood Coagulation; Dose-Response Relationship, Drug; Humans; Monitoring, Physiologic; Partial Thromboplastin Time; Pipecolic Acids; Platelet Aggregation Inhibitors; Sulfonamides; Thrombelastography | 2010 |
[Anesthetic management for a patient with heparin-induced thrombocytopenia (HIT) undergoing off-pump coronary bypass surgery using argatroban, a direct thrombin inhibitor].
Topics: Aged; Anesthesia; Angina Pectoris; Anticoagulants; Arginine; Coronary Artery Bypass, Off-Pump; Heparin; Humans; Infusions, Intravenous; Intraoperative Care; Male; Pipecolic Acids; Sulfonamides; Thrombocytopenia | 2009 |
Heparin-induced thrombocytopenia with multiple organized thrombi accompanied by unusual cholesterin deposition: autopsy case after long-term follow up.
Topics: Aged; Anticoagulants; Arginine; Embolism, Cholesterol; Fatal Outcome; Heparin; Humans; Male; Pipecolic Acids; Platelet Count; Sulfonamides; Thrombocytopenia; Thrombosis; Warfarin | 2009 |
[Heparin-induced thrombocytopenia type II with thrombosis in an intensive care patient: therapy management using the direct thrombin inhibitor argatroban].
Topics: Aged; Anticoagulants; Aortic Aneurysm, Abdominal; Aortic Rupture; Arginine; Exanthema; Heparin; Humans; Male; Partial Thromboplastin Time; Pipecolic Acids; Platelet Count; Sulfonamides; Thrombin; Thrombocytopenia; Thrombosis | 2009 |
Autologous small-caliber "biotube" vascular grafts with argatroban loading: a histomorphological examination after implantation to rabbits.
Topics: Animals; Arginine; Blood Vessel Prosthesis; Pipecolic Acids; Rabbits; Sulfonamides; Tissue Engineering | 2010 |
Thrombin inhibition in subarachnoid hemorrhage.
Topics: Animals; Arginine; Disease Models, Animal; Humans; Pipecolic Acids; Platelet Aggregation Inhibitors; Subarachnoid Hemorrhage; Sulfonamides; Thrombin | 2009 |
Inhibition of thrombin action ameliorates insulin resistance in type 2 diabetic db/db mice.
Topics: 3T3-L1 Cells; Adipocytes; Adiponectin; Adipose Tissue; Animals; Anticoagulants; Arginine; Blood Glucose; Diabetes Mellitus, Type 2; Drug Tolerance; Factor VII; Humans; Insulin; Insulin Resistance; Interleukin-6; Macrophages; Mice; Mice, Inbred Strains; Pipecolic Acids; Platelet Aggregation Inhibitors; Receptors, CCR2; Reverse Transcriptase Polymerase Chain Reaction; RNA; Sulfonamides; Thrombin | 2010 |
Prolonged elevation of plasma argatroban in a cardiac transplant patient with a suspected history of heparin-induced thrombocytopenia with thrombosis.
Topics: Aged; Arginine; Blood Coagulation Disorders; Cardiopulmonary Bypass; Child; Heart Transplantation; Heparin; Humans; Infusions, Intravenous; Pipecolic Acids; Platelet Aggregation Inhibitors; Sulfonamides; Thrombocytopenia; Thrombosis | 2010 |
Cooperative antithrombotic effect from the simultaneous inhibition of thrombin and factor Xa.
Topics: Animals; Arginine; Blood Coagulation; Drug Synergism; Factor Xa; Factor Xa Inhibitors; Guanidines; Humans; Male; Naphthalenes; Pipecolic Acids; Piperidines; Rats; Rats, Sprague-Dawley; Sulfonamides; Thrombin | 2010 |
Argatroban "reversal" is caused by nonphysiologic stimulation of coagulation, not activated factor VII.
Topics: Anticoagulants; Arginine; Blood Coagulation; Factor VIIa; Humans; Kaolin; Pharmaceutic Aids; Pipecolic Acids; Sulfonamides; Thrombelastography; Thrombin | 2010 |
Quantitation of argatroban in plasma using liquid chromatography electrospray tandem mass spectrometry (UPLC-ESI-MS/MS).
Topics: Arginine; Chromatography, Liquid; Humans; Pipecolic Acids; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Sulfonamides; Tandem Mass Spectrometry | 2010 |
Argatroban and renal replacement therapy in a morbidly obese patient with heparin-induced thrombocytopenia: a case report.
Topics: Acute Kidney Injury; Adult; Anticoagulants; Arginine; Heparin; Humans; Male; Obesity, Morbid; Pipecolic Acids; Renal Replacement Therapy; Respiratory Distress Syndrome; Shock, Septic; Sulfonamides; Thrombocytopenia | 2010 |
Simultaneous use of argatroban and heparin during cardiopulmonary bypass.
Topics: Animals; Anticoagulants; Antithrombin III; Arginine; Blood Coagulation; Blood Platelets; Cardiopulmonary Bypass; Dogs; Drug Administration Schedule; Drug Therapy, Combination; Fibrinogen; Hemoglobins; Heparin; Infusions, Intravenous; Intraoperative Care; Pipecolic Acids; Sulfonamides; Thrombin | 2010 |
Difficult management of anticoagulation with argatroban in a patient undergoing on-pump cardiac surgery.
Topics: Aged; Anticoagulants; Arginine; Cardiac Surgical Procedures; Disease Management; Female; Humans; International Normalized Ratio; Pipecolic Acids; Postoperative Hemorrhage; Sulfonamides; Thrombocytopenia | 2010 |
The direct thrombin inhibitor argatroban effectively prevents cardiac catheter thrombosis in vitro.
Topics: Anticoagulants; Antithrombin III; Arginine; Blood Coagulation; Blood Platelets; Cardiac Catheterization; Enoxaparin; Factor Xa; Factor Xa Inhibitors; Fibrin; Heparin; Humans; Male; Peptide Hydrolases; Pipecolic Acids; Stress, Mechanical; Sulfonamides; Thrombin; Thrombosis; Time Factors | 2010 |
Treatment with argatroban in one haemodialysed patient with a heparin-induced thrombocytopenia and thrombotic complications.
Topics: Aged, 80 and over; Arginine; Female; Heparin; Humans; Pipecolic Acids; Platelet Aggregation Inhibitors; Renal Dialysis; Sulfonamides; Thrombocytopenia; Thrombosis | 2010 |
The direct thrombin inhibitors (argatroban, bivalirudin and lepirudin) and the indirect Xa-inhibitor (danaparoid) increase fibrin network porosity and thus facilitate fibrinolysis.
Topics: Antithrombins; Arginine; Chondroitin Sulfates; Chromatography, Gel; Dermatan Sulfate; Factor VIII; Factor Xa Inhibitors; Fibrin; Fibrinolysis; Heparinoids; Heparitin Sulfate; Hirudins; Humans; In Vitro Techniques; Microscopy, Confocal; Peptide Fragments; Pipecolic Acids; Plasma; Porosity; Protein Multimerization; Recombinant Proteins; Sulfonamides; Thrombosis; Tissue Plasminogen Activator | 2010 |
Pharmacokinetic and pharmacodynamic basis for effective argatroban dosing in pediatrics.
Topics: Adolescent; Arginine; Bilirubin; Body Weight; Child; Child, Preschool; Computer Simulation; Dose-Response Relationship, Drug; Female; Hemorrhage; Humans; Infant; Infant, Newborn; Male; Models, Biological; Partial Thromboplastin Time; Pipecolic Acids; Platelet Aggregation Inhibitors; Sulfonamides | 2011 |
Safety and efficacy of the argatroban therapy during the early post-cardiac surgery period.
Topics: Aged; Aged, 80 and over; Arginine; Cardiac Surgical Procedures; Drug-Related Side Effects and Adverse Reactions; Female; Hemorrhage; Hospital Mortality; Humans; Male; Middle Aged; Pipecolic Acids; Postoperative Care; Postoperative Complications; Retrospective Studies; Sulfonamides; Thrombin; Thrombosis; Treatment Outcome | 2010 |
Argatroban therapy for heparin-induced thrombocytopenia in ICU patients with multiple organ dysfunction syndrome: a retrospective study.
Topics: Aged; Aged, 80 and over; Anticoagulants; Antithrombins; Arginine; Critical Care; Dose-Response Relationship, Drug; Female; Heparin; Humans; Intensive Care Units; Male; Middle Aged; Multiple Organ Failure; Pipecolic Acids; Retrospective Studies; Sulfonamides; Survival Analysis; Thrombocytopenia | 2010 |
Serious acute coronary thrombosis associated with heparin-induced thrombocytopenia in off-pump coronary artery bypass grafting.
Topics: Acute Disease; Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Arginine; Atherectomy, Coronary; Coronary Angiography; Coronary Artery Bypass, Off-Pump; Coronary Thrombosis; Female; Graft Occlusion, Vascular; Heparin; Humans; Pipecolic Acids; Stents; Sulfonamides; Thrombocytopenia; Time Factors; Treatment Outcome | 2010 |
[Heparin-induced thrombocytopenia after on-pump coronary artery bypass grafting].
Topics: Anticoagulants; Arginine; Coronary Artery Bypass; Female; Heparin; Humans; Middle Aged; Pipecolic Acids; Postoperative Complications; Sulfonamides; Thrombocytopenia | 2010 |
Fondaparinux therapy in a hemodialysis patient with heparin-induced thrombocytopenia type II.
Topics: Aged, 80 and over; Anticoagulants; Arginine; Coronary Artery Bypass; Female; Fondaparinux; Heparin; Humans; Mitral Valve; Pipecolic Acids; Platelet Aggregation Inhibitors; Platelet Count; Polysaccharides; Renal Dialysis; Sulfonamides; Thrombocytopenia; Venous Thrombosis | 2010 |
Apixaban, a direct factor Xa inhibitor, inhibits tissue-factor induced human platelet aggregation in vitro: comparison with direct inhibitors of factor VIIa, XIa and thrombin.
Topics: Adenosine Diphosphate; Anticoagulants; Arginine; Azetidines; Benzimidazoles; Collagen; Dabigatran; Dose-Response Relationship, Drug; Factor VIIa; Factor Xa; Factor Xa Inhibitors; Factor XIa; Humans; Morpholines; Pipecolic Acids; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Sulfonamides; Thiophenes; Thrombin; Thromboplastin; Time Factors | 2010 |
Argatroban administration reduces leukocyte adhesion and improves capillary perfusion within the intestinal microcirculation in experimental sepsis.
Topics: Animals; Anticoagulants; Arginine; Blood Pressure; Capillaries; Cell Adhesion; Disease Models, Animal; Heart Rate; Intestines; Leukocytes; Male; Microcirculation; Microscopy, Video; Myography; Pipecolic Acids; Rats; Rats, Inbred Lew; Sepsis; Splanchnic Circulation; Sulfonamides; Time Factors; Vasodilation | 2010 |
Monitoring of the anticoagulants argatroban and lepirudin: a comparison of laboratory methods.
Topics: Antithrombins; Arginine; Calibration; Female; Hirudins; Humans; Male; Partial Thromboplastin Time; Pipecolic Acids; Prothrombin Time; Recombinant Proteins; Sulfonamides; Thrombin Time | 2011 |
Carbon monoxide releasing molecule-2 enhances coagulation and diminishes fibrinolytic vulnerability in plasma exposed to heparin or argatroban.
Topics: Anticoagulants; Arginine; Blood Coagulation; Coagulants; Fibrinolysis; Heparin; Humans; Kinetics; Organometallic Compounds; Pipecolic Acids; Sulfonamides; Thrombelastography; Thromboplastin; Tissue Plasminogen Activator | 2010 |
A patient with 'spontaneous' heparin-induced thrombocytopenia and thrombosis after undergoing knee replacement.
Topics: Anticoagulants; Antithrombins; Arginine; Arthroplasty, Replacement, Knee; Autoantibodies; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Platelet Factor 4; Sulfonamides; Thrombocytopenia; Venous Thrombosis | 2011 |
Comparison of bivalirudin and argatroban for the management of heparin-induced thrombocytopenia.
Topics: Antithrombins; Arginine; Female; Heparin; Hirudins; Humans; Male; Middle Aged; Partial Thromboplastin Time; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Retrospective Studies; Sulfonamides; Thrombocytopenia; Time Factors | 2010 |
Thrombolytic therapy and thrombectomy in phlegmasia cerulea dolens.
Topics: Anticoagulants; Antithrombins; Arginine; Fibrinolytic Agents; Heparin; Hirudins; Humans; Pipecolic Acids; Platelet Aggregation Inhibitors; Recombinant Proteins; Sulfonamides; Thrombectomy; Thrombocytopenia; Time Factors; Venous Thrombosis | 2010 |
Extracorporeal membrane oxygenation bridging to lung transplant complicated by heparin-induced thrombocytopenia.
Topics: Adult; Anticoagulants; Arginine; Extracorporeal Membrane Oxygenation; Fatal Outcome; Heparin; Humans; Lung Transplantation; Male; Multiple Organ Failure; Pipecolic Acids; Respiration, Artificial; Respiratory Distress Syndrome; Respiratory Insufficiency; Sulfonamides; Thrombocytopenia; Time Factors; Treatment Outcome | 2010 |
[Interventional lung assist membrane ventilator. Successful use despite heparin-induced thrombocytopenia type II].
Topics: Aged; Anticoagulants; Arginine; Extracorporeal Membrane Oxygenation; Heparin; Humans; Lung Neoplasms; Male; Perioperative Care; Pipecolic Acids; Platelet Aggregation Inhibitors; Platelet Count; Postoperative Complications; Pulmonary Disease, Chronic Obstructive; Respiratory Distress Syndrome; Respiratory Insufficiency; Smoking; Sulfonamides; Thrombocytopenia | 2011 |
Venous limb gangrene and fatal hemorrhage: adverse consequences of HIT "overdiagnosis" in a patient with antiphospholipid syndrome.
Topics: Anticoagulants; Antiphospholipid Syndrome; Arginine; Diagnostic Errors; Drug Monitoring; Fatal Outcome; Female; Gangrene; Hemorrhage; Humans; Lung Diseases; Middle Aged; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Upper Extremity; Vascular Diseases; Warfarin | 2011 |
Effects of argatroban as an anticoagulant for intermittent veno-venous hemofiltration (IVVH) in patients at high risk of bleeding.
Topics: Acute Kidney Injury; Anticoagulants; Arginine; Cohort Studies; Female; Follow-Up Studies; Hemofiltration; Hemorrhage; Humans; Male; Middle Aged; Pipecolic Acids; Prognosis; Prospective Studies; Renal Replacement Therapy; Risk Factors; Sulfonamides; Survival Rate | 2011 |
Use of argatroban as a procedural and bridging anticoagulant in a patient undergoing carotid endarterectomy with concomitant atrial fibrillation.
Topics: Aged; Anticoagulants; Arginine; Atrial Fibrillation; Blood Coagulation Tests; Carotid Stenosis; Endarterectomy, Carotid; Female; Heparin; Humans; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Warfarin | 2011 |
Argatroban therapy using enzymatic anti-factor IIa monitoring.
Topics: Antithrombins; Arginine; Drug Monitoring; Humans; Pipecolic Acids; Prothrombin; Sulfonamides | 2011 |
Practical viewpoints on the diagnosis and management of heparin-induced thrombocytopenia.
Topics: Aged; Anticoagulants; Arginine; Cardiac Catheterization; Cardiac Surgical Procedures; Chondroitin Sulfates; Dermatan Sulfate; Female; Heparin; Heparin, Low-Molecular-Weight; Heparitin Sulfate; Hirudins; Humans; Male; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Vascular Surgical Procedures; Vitamin K; Young Adult | 2011 |
Argatroban therapy in pediatric patients requiring nonheparin anticoagulation: an open-label, safety, efficacy, and pharmacokinetic study.
Topics: Anticoagulants; Arginine; Child; Child, Preschool; Female; Hemorrhage; Heparin; Humans; Infant; Liver Function Tests; Male; Pipecolic Acids; Platelet Aggregation Inhibitors; Prospective Studies; Sulfonamides; Survival Rate; Thrombocytopenia; Thrombosis; Tissue Distribution; Treatment Outcome | 2011 |
Hypereosinophilic syndrome with cardiac involvement in a pregnant patient with multiple sclerosis.
Topics: Adult; Anticoagulants; Arginine; Drug Substitution; Female; Glucocorticoids; Heparin; Humans; Hypereosinophilic Syndrome; Multiple Sclerosis; Pipecolic Acids; Prednisone; Pregnancy; Pregnancy Complications, Cardiovascular; Sulfonamides; Thrombocytopenia; Treatment Outcome | 2011 |
[Diagnosis and treatment of heparin-induced thrombocytopenia].
Topics: Acute Kidney Injury; Aged; Anticoagulants; Antithrombins; Aortic Valve Stenosis; Arginine; Diagnosis, Differential; Hand; Heparin; Humans; Ischemia; Male; Pipecolic Acids; Platelet Count; Renal Dialysis; Shock, Cardiogenic; Sulfonamides; Thrombocytopenia; Ventricular Dysfunction, Left | 2011 |
Long-term animal implantation study of biotube-autologous small-caliber vascular graft fabricated by in-body tissue architecture.
Topics: Animals; Antithrombins; Arginine; Bioprosthesis; Blood Vessel Prosthesis; Blood Vessel Prosthesis Implantation; Carotid Arteries; Pipecolic Acids; Rabbits; Silicones; Stents; Sulfonamides | 2011 |
Combined argatroban and anti-oxidative agents prevents increased vascular contractility to thrombin and other ligands after subarachnoid haemorrhage.
Topics: Animals; Antioxidants; Arginine; Ascorbic Acid; Drug Therapy, Combination; Male; Pipecolic Acids; Rabbits; Receptor, PAR-1; Signal Transduction; Subarachnoid Hemorrhage; Sulfonamides; Thiobarbituric Acid Reactive Substances; Thrombin; Thrombosis; Vasoconstriction | 2012 |
Profiling of active thrombin in human blood by supramolecular complexes.
Topics: Aptamers, Nucleotide; Arginine; Binding Sites; Blood Coagulation; Coumarins; Enzyme Assays; Humans; Limit of Detection; Peptides; Pipecolic Acids; Sensitivity and Specificity; Sulfonamides; Thrombin | 2011 |
Heparin-induced thrombocytopenia type II because of heparin-coated polytetrafluoroethylene graft used to bypass.
Topics: Aged; Anticoagulants; Arginine; Arterial Occlusive Diseases; Blood Vessel Prosthesis; Blood Vessel Prosthesis Implantation; Coated Materials, Biocompatible; Device Removal; Early Diagnosis; Female; Heparin; Humans; Lower Extremity; Pipecolic Acids; Polytetrafluoroethylene; Prosthesis Design; Reoperation; Sulfonamides; Thrombocytopenia; Treatment Outcome | 2011 |
Novel insights into the delayed vasospasm following subarachnoid haemorrhage: importance of proteinase signalling.
Topics: Animals; Antioxidants; Arginine; Male; Pipecolic Acids; Subarachnoid Hemorrhage; Sulfonamides; Thrombin; Vasoconstriction | 2012 |
Implementation of an individualized argatroban protocol in an academic medical center.
Topics: Academic Medical Centers; Arginine; Clinical Protocols; Hemorrhage; Humans; Pipecolic Acids; Precision Medicine; Prothrombin Time; Retrospective Studies; Sulfonamides | 2011 |
Management of argatroban surrounding a lumbar puncture: a case report.
Topics: Aged; Antithrombins; Arginine; Female; Humans; Partial Thromboplastin Time; Pipecolic Acids; Seizures; Spinal Puncture; Sulfonamides; Thrombocytopenia; Time Factors; Treatment Outcome | 2011 |
Immobilization of anticoagulant-loaded liposomes on cell surfaces by DNA hybridization.
Topics: Animals; Anticoagulants; Antithrombins; Arginine; Cell Line, Tumor; Cell Membrane; DNA; Fluorescent Dyes; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Liposomes; Male; Mice; Mice, Inbred BALB C; Nucleic Acid Hybridization; Pipecolic Acids; Sulfonamides | 2011 |
Systemic administration of argatroban inhibits protease-activated receptor-1 expression in perihematomal tissue in rats with intracerebral hemorrhage.
Topics: Animals; Arginine; Blotting, Western; Body Water; Brain Chemistry; Brain Edema; Cerebral Hemorrhage; Female; Male; Pipecolic Acids; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Receptor, PAR-1; Stereotaxic Techniques; Sulfonamides | 2011 |
Water-soluble argatroban for antithrombogenic surface coating of tissue-engineered cardiovascular tissues.
Topics: Adsorption; Animals; Arginine; Blood Vessel Prosthesis; Coated Materials, Biocompatible; Coloring Agents; Connective Tissue; Dogs; Female; Heart Valve Prosthesis; Humans; Ions; Materials Testing; Models, Chemical; Pipecolic Acids; Solubility; Sulfonamides; Surface Properties; Tissue Engineering; Water | 2011 |
The argatroban and tissue-type plasminogen activator stroke study: final results of a pilot safety study.
Topics: Aged; Anticoagulants; Antithrombins; Arginine; Brain Ischemia; Cerebral Arteries; Cerebral Hemorrhage; Cerebral Veins; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Partial Thromboplastin Time; Pilot Projects; Pipecolic Acids; Stroke; Sulfonamides; Tissue Plasminogen Activator; Treatment Outcome; Ultrasonography, Doppler, Transcranial | 2012 |
The argatroban and tissue-type plasminogen activator stroke study: final results of a pilot safety study.
Topics: Anticoagulants; Antithrombins; Arginine; Female; Humans; Male; Pipecolic Acids; Stroke; Sulfonamides; Tissue Plasminogen Activator | 2012 |
Identifying patient- and treatment-related factors related to amputation risk in cases of heparin-induced thrombocytopenia treated with argatroban.
Topics: Aged; Amputation, Surgical; Anticoagulants; Antithrombins; Arginine; Chi-Square Distribution; Clinical Trials as Topic; Female; Heparin; Humans; Male; Middle Aged; Multicenter Studies as Topic; Pipecolic Acids; Retrospective Studies; Risk Assessment; Risk Factors; Sulfonamides; Thrombocytopenia; Time Factors; Treatment Failure | 2011 |
Left ventricular thrombus during cardiopulmonary bypass as the primary manifestation of heparin-induced thrombocytopenia.
Topics: Anticoagulants; Arginine; Cardiopulmonary Bypass; Echocardiography, Transesophageal; Heparin; Humans; Intraoperative Complications; Male; Middle Aged; Pipecolic Acids; Platelet Aggregation Inhibitors; Platelet Count; Sulfonamides; Thrombocytopenia; Thromboembolism; Ventricular Dysfunction, Left | 2013 |
Development and implementation of a comprehensive heparin-induced thrombocytopenia recognition and management protocol.
Topics: Academic Medical Centers; Anticoagulants; Antithrombins; Arginine; Heparin; Hirudins; Humans; Joint Commission on Accreditation of Healthcare Organizations; Patient Education as Topic; Pharmacists; Pipecolic Acids; Practice Guidelines as Topic; Quality Assurance, Health Care; Recombinant Proteins; Sulfonamides; Thrombin; Thrombocytopenia; United States | 2012 |
Thrombin inhibition profiles in healthy individuals and thrombophilic patients.
Topics: Adult; Aged; Antibodies, Antiphospholipid; Antiphospholipid Syndrome; Antithrombin Proteins; Antithrombins; Arginine; Blood Coagulation; Blood Coagulation Tests; Case-Control Studies; Female; Germany; Half-Life; Humans; Kinetics; Male; Middle Aged; Phenotype; Pipecolic Acids; Sulfonamides; Thrombin; Thrombophilia; Young Adult | 2012 |
Recognition of heparin-induced thrombocytopenia and initiation of argatroban therapy after cardiothoracic surgery in the intensive care unit.
Topics: Antibodies; Anticoagulants; Arginine; Cardiac Surgical Procedures; Drug Substitution; Georgia; Hemorrhage; Heparin; Humans; Intensive Care Units; Pipecolic Acids; Platelet Factor 4; Predictive Value of Tests; Retrospective Studies; Risk Assessment; Risk Factors; Sulfonamides; Thoracic Surgical Procedures; Thrombocytopenia; Thrombosis; Time Factors; Treatment Outcome | 2012 |
Argatroban anticoagulation for heparin induced thrombocytopenia in patients with ventricular assist devices.
Topics: Adult; Aged; Anticoagulants; Arginine; Feasibility Studies; Female; Heart Transplantation; Heart-Assist Devices; Heparin; Hospital Mortality; Humans; Incidence; Infusions, Intravenous; Male; Middle Aged; Partial Thromboplastin Time; Pipecolic Acids; Postoperative Complications; Postoperative Hemorrhage; Retrospective Studies; Sulfonamides; Thrombocytopenia; Thromboembolism; Treatment Outcome | 2012 |
The thrombin inhibitor, argatroban, inhibits breast cancer metastasis to bone.
Topics: Animals; Antithrombins; Arginine; Body Weight; Bone Neoplasms; Breast Neoplasms; Enzyme-Linked Immunosorbent Assay; Female; Humans; Mice; Pipecolic Acids; Sulfonamides; Thrombin; Thromboplastin; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A | 2013 |
Argatroban therapy for heparin-induced thrombocytopenia during pregnancy in a woman with hereditary antithrombin deficiency.
Topics: Adult; Anticoagulants; Antithrombins; Arginine; Blood Coagulation Disorders, Inherited; Female; Heparin; Humans; Male; Pipecolic Acids; Pregnancy; Pregnancy Complications, Hematologic; Sulfonamides; Thrombocytopenia; Venous Thrombosis | 2012 |
High-dose argatroban for treatment of heparin-induced thrombocytopenia with thrombosis: a case report and review of laboratory considerations.
Topics: Anticoagulants; Arginine; Dose-Response Relationship, Drug; Drug Monitoring; Female; Heparin; Humans; International Normalized Ratio; Middle Aged; Pipecolic Acids; Platelet Aggregation Inhibitors; Sulfonamides; Thrombocytopenia; Thrombosis | 2012 |
Development of a fast and simple liquid chromatography-tandem mass spectrometry method for the quantitation of argatroban in patient plasma samples.
Topics: Arginine; Chromatography, High Pressure Liquid; Drug Monitoring; Humans; Linear Models; Pipecolic Acids; Reproducibility of Results; Sulfonamides; Tandem Mass Spectrometry | 2012 |
Heparin-induced thrombocytopenia in essential thrombocytosis.
Topics: Aged; Anticoagulants; Arginine; Arterial Occlusive Diseases; Bone Marrow Examination; Cerebral Infarction; Constriction, Pathologic; Diagnosis, Differential; Disseminated Intravascular Coagulation; Female; Femoral Artery; Heparin; Humans; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Pipecolic Acids; Platelet Aggregation Inhibitors; Platelet Count; Predictive Value of Tests; Sulfonamides; Thrombocythemia, Essential; Thrombocytopenia; Thrombophlebitis; Treatment Outcome | 2012 |
A case of acute coronary artery occlusion associated with very rapid onset heparin-induced thrombosis without thrombocytopenia.
Topics: Aged, 80 and over; Angioplasty, Balloon, Coronary; Anticoagulants; Arginine; Aspirin; Autoantibodies; Cilostazol; Clopidogrel; Coronary Angiography; Coronary Occlusion; Drug Therapy, Combination; Female; Heart Failure; Heparin; Humans; Pipecolic Acids; Platelet Count; Platelet Factor 4; Stents; Sulfonamides; Tetrazoles; Thrombosis; Ticlopidine; Time Factors | 2012 |
Use of the chromogenic factor X assay in patients transitioning from argatroban to warfarin therapy.
Topics: Academic Medical Centers; Anticoagulants; Arginine; Blood Coagulation; Chromogenic Compounds; Databases, Factual; Drug Administration Schedule; Electronic Health Records; Factor X; Hospitals, Teaching; Humans; International Normalized Ratio; Male; Middle Aged; Pipecolic Acids; Predictive Value of Tests; Retrospective Studies; Sensitivity and Specificity; Sulfonamides; Warfarin | 2012 |
In vivo fluorescence imaging of atherosclerotic plaques with activatable cell-penetrating peptides targeting thrombin activity.
Topics: Amino Acid Sequence; Animals; Antithrombins; Aorta; Arginine; Cell-Penetrating Peptides; Fluorescent Dyes; Hirudins; Histocytochemistry; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microscopy, Fluorescence; Pipecolic Acids; Plaque, Atherosclerotic; Receptor, PAR-1; Recombinant Proteins; Sulfonamides; Thrombin | 2012 |
High-dose argatroban therapy for stroke: novel treatment for delayed treatment and the recanalization mechanism.
Topics: Aged; Aged, 80 and over; Antithrombins; Arginine; Blood Coagulation; Constriction, Pathologic; Drug Administration Schedule; Female; Humans; Infarction, Middle Cerebral Artery; Infusions, Intravenous; Magnetic Resonance Angiography; Male; Middle Cerebral Artery; Pipecolic Acids; Sulfonamides; Time Factors; Time-to-Treatment; Treatment Outcome | 2013 |
[Anesthesia for a hemodialysis patient with HIT undergoing CABG using argatroban].
Topics: Aged, 80 and over; Anesthesia, General; Anticoagulants; Antithrombins; Arginine; Coronary Artery Bypass; Heparin; Humans; Male; Pipecolic Acids; Renal Dialysis; Sulfonamides; Thrombocytopenia | 2012 |
The serological profile of fondaparinux-associated heparin-induced thrombocytopenia syndrome.
Topics: Aged; Arginine; Female; Fondaparinux; Heparin; Humans; Immunoenzyme Techniques; Inflammation; Pipecolic Acids; Platelet Factor 4; Polysaccharides; Sulfonamides; Syndrome; Thrombocytopenia; Treatment Outcome | 2012 |
Choice of drugs for heparin-induced thrombocytopenia.
Topics: Anticoagulants; Arginine; Factor Xa Inhibitors; Fondaparinux; Heparin; Humans; Pipecolic Acids; Polysaccharides; Sulfonamides; Thrombocytopenia | 2012 |
Thrombin activity associated with neuronal damage during acute focal ischemia.
Topics: Amino Acids; Analysis of Variance; Animals; Antithrombins; Arginine; Avoidance Learning; Brain Injuries; Cell Death; Cognition Disorders; Disease Models, Animal; Factor X; Fibrinolysin; Gene Expression Regulation; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Male; Maze Learning; Motor Activity; Nerve Tissue Proteins; Pipecolic Acids; Pyrroles; Rats; Reaction Time; Receptor, PAR-1; Sulfonamides; Thrombin; Time Factors | 2012 |
Hemodialysis with a dialyzer loaded with argatroban may be performed in vivo without a systemic anticoagulant.
Topics: Acrylic Resins; Animals; Anticoagulants; Antithrombin III; Arginine; Blood Coagulation; Dogs; Fibrin Fibrinogen Degradation Products; Male; Membranes, Artificial; Partial Thromboplastin Time; Peptide Hydrolases; Pipecolic Acids; Renal Dialysis; Sulfonamides | 2012 |
Treatment outcomes of heparin-induced thrombocytopenia in subarachnoid hemorrhage patients: a 4-year, retrospective single-center review.
Topics: Adult; Aged; Antibodies, Anti-Idiotypic; Anticoagulants; Arginine; Female; Fondaparinux; Heparin; Humans; Immunoglobulin G; Male; Middle Aged; Pipecolic Acids; Platelet Aggregation Inhibitors; Platelet Factor 4; Polysaccharides; Purpura, Thrombotic Thrombocytopenic; Retrospective Studies; Subarachnoid Hemorrhage; Sulfonamides; Thrombocytopenia; Treatment Outcome | 2012 |
The therapeutic management of bleeding and thrombotic disorders complicating CNS malignancies.
Topics: Antibodies, Monoclonal, Humanized; Anticoagulants; Arginine; Bevacizumab; Central Nervous System Neoplasms; Fondaparinux; Glioblastoma; Glioma; Hemorrhage; Heparin, Low-Molecular-Weight; Hirudins; Humans; Pipecolic Acids; Polysaccharides; Postoperative Complications; Pulmonary Embolism; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Vena Cava Filters; Venous Thromboembolism; Venous Thrombosis; Warfarin | 2012 |
Therapeutic administration of the direct thrombin inhibitor argatroban reduces hepatic inflammation in mice with established fatty liver disease.
Topics: Animals; Arginine; Chemokine CCL2; Chemokine CXCL2; Collagen; Diet; Fatty Liver; Feeding Behavior; Gene Expression Regulation; Inflammation; Intercellular Adhesion Molecule-1; Lipid Metabolism; Lipids; Liver; Liver Cirrhosis; Macrophages; Male; Mice; Mice, Inbred C57BL; Neutrophils; Pipecolic Acids; Receptors, LDL; RNA, Messenger; Sulfonamides; Thrombin; Weight Gain | 2012 |
In vitro studies using a global hemostasis assay to examine the anticoagulation effects in plasma by the direct thrombin inhibitors: dabigatran and argatroban.
Topics: Aged; Anticoagulants; Antithrombins; Arginine; Benzimidazoles; beta-Alanine; Blood Coagulation; Blood Coagulation Tests; Dabigatran; Dose-Response Relationship, Drug; Female; Hemostasis; Humans; Middle Aged; Pipecolic Acids; Sulfonamides; Treatment Outcome | 2013 |
Alternative anticoagulation during cardiovascular procedures in pediatric patients with heparin-induced thrombocytopenia.
Topics: Antithrombins; Arginine; Cardiopulmonary Bypass; Heparin; Hirudins; Humans; Infant; Infant, Newborn; Male; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2012 |
Direct thrombin inhibitors for management of heparin-induced thrombocytopenia in patients receiving renal replacement therapy: comparison of clinical outcomes.
Topics: Adult; Aged; Anticoagulants; Antithrombins; Arginine; Female; Heparin; Hirudins; Humans; International Normalized Ratio; Male; Middle Aged; Peptide Fragments; Pipecolic Acids; Platelet Count; Recombinant Proteins; Renal Replacement Therapy; Retrospective Studies; Serum Albumin; Sulfonamides; Thrombocytopenia | 2012 |
Measuring direct thrombin inhibitors with routine and dedicated coagulation assays: which assay is helpful?
Topics: Antithrombins; Arginine; Blood Coagulation; Chromogenic Compounds; Diagnostic Tests, Routine; Endopeptidases; Fibrinolytic Agents; Hirudins; Humans; Partial Thromboplastin Time; Peptide Fragments; Pipecolic Acids; Prothrombin Time; Recombinant Proteins; Sulfonamides; Thrombin; Thrombin Time | 2012 |
Argatroban dose reductions for suspected heparin-induced thrombocytopenia complicated by child-pugh class C liver disease.
Topics: Anticoagulants; Antithrombins; Arginine; End Stage Liver Disease; Heparin; Humans; Kidney Failure, Chronic; Liver Cirrhosis, Alcoholic; Male; Middle Aged; Pipecolic Acids; Platelet Aggregation Inhibitors; Sulfonamides; Thrombocytopenia | 2012 |
Safety and effectiveness outcomes of an inpatient collaborative drug therapy management service for direct thrombin inhibitors.
Topics: Adult; Aged; Antithrombins; Arginine; Cohort Studies; Cooperative Behavior; Drug Monitoring; Female; Hemorrhage; Heparin; Hirudins; Humans; Inpatients; Male; Medication Errors; Middle Aged; Outcome Assessment, Health Care; Partial Thromboplastin Time; Peptide Fragments; Pharmacists; Pharmacy Service, Hospital; Pipecolic Acids; Recombinant Proteins; Retrospective Studies; Sulfonamides; Thrombocytopenia; Time Factors | 2012 |
Autoantibody-mediated arthritis in the absence of C3 and activating Fcγ receptors: C5 is activated by the coagulation cascade.
Topics: Animals; Antibodies, Monoclonal; Antithrombins; Arginine; Arthritis; Autoantibodies; Blood Coagulation; Complement Activation; Complement C3; Complement C5; Female; Flow Cytometry; Glucose-6-Phosphate Isomerase; Immunohistochemistry; Male; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Knockout; Mice, Transgenic; Pipecolic Acids; Receptors, Antigen, T-Cell; Receptors, IgG; Signal Transduction; Sulfonamides | 2012 |
Recurring extracorporeal circuit clotting during continuous renal replacement therapy in fungal sepsis: successful treatment with argatroban.
Topics: Antifungal Agents; Antithrombins; Arginine; Blood Coagulation; Coronary Artery Bypass; Humans; Male; Mediastinitis; Middle Aged; Mycoses; Phosphorylcholine; Pipecolic Acids; Postoperative Complications; Renal Replacement Therapy; Scedosporium; Sepsis; Sulfonamides | 2013 |
Effects of argatroban, danaparoid, and fondaparinux on trombin generation in heparin-induced thrombocytopenia.
Topics: Aged; Aged, 80 and over; Anticoagulants; Arginine; Blood Platelets; Calibration; Chondroitin Sulfates; Dermatan Sulfate; Female; Fondaparinux; Heparin; Heparitin Sulfate; Humans; Male; Middle Aged; Pipecolic Acids; Plasma; Platelet-Rich Plasma; Polysaccharides; Recombinant Proteins; Sulfonamides; Thrombin; Thrombocytopenia; Time Factors | 2013 |
A quantitative affinity-based technique for the identification of potential lead compounds.
Topics: Animals; Antithrombins; Arginine; Cattle; Chromatography, Gel; Chromatography, Liquid; Drug Evaluation, Preclinical; Inhibitory Concentration 50; Mass Spectrometry; Pipecolic Acids; Proteins; Reproducibility of Results; Sulfonamides; Thrombin | 2013 |
Catheter-directed thrombolysis with argatroban and tPA for massive iliac and femoropopliteal vein thrombosis.
Topics: Arginine; Catheterization, Peripheral; Catheters; Drug Therapy, Combination; Female; Femoral Vein; Fibrinolytic Agents; Follow-Up Studies; Humans; Iliac Vein; Male; Middle Aged; Phlebography; Pipecolic Acids; Platelet Aggregation Inhibitors; Popliteal Vein; Recurrence; Severity of Illness Index; Sulfonamides; Thrombolytic Therapy; Tissue Plasminogen Activator; Treatment Outcome; Venous Thrombosis | 2013 |
Ecarin modified rotational thrombelastometry: a point-of-care applicable alternative to monitor the direct thrombin inhibitor argatroban.
Topics: Antithrombins; Arginine; Blood Coagulation; Drug Monitoring; Endopeptidases; Fibrinolytic Agents; Humans; Pipecolic Acids; Point-of-Care Systems; Sulfonamides; Thrombelastography | 2013 |
Monitoring the direct thrombin inhibitors.
Topics: Antithrombins; Arginine; Benzimidazoles; beta-Alanine; Dabigatran; Drug Monitoring; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides | 2013 |
Alternative monitoring of argatroban using plasma-diluted thrombin time.
Topics: Aged, 80 and over; Arginine; Drug Monitoring; Humans; Liver Diseases; Male; Pipecolic Acids; Sulfonamides; Thrombin Time; Thrombocytopenia | 2013 |
Elevated plasma factor VIII enhances venous thrombus formation in rabbits: contribution of factor XI, von Willebrand factor and tissue factor.
Topics: Animals; Antibodies, Blocking; Arginine; Blood Platelets; Factor VIII; Factor XI; Hemostasis; Humans; Jugular Veins; Male; Pipecolic Acids; Platelet Aggregation; Rabbits; Sulfonamides; Thrombin; Thromboplastin; Venous Thrombosis; von Willebrand Factor | 2013 |
[Management of cardiopulmonary bypass during cardiac surgery for patients with heparin-induced thrombocytopenia].
Topics: Aged; Antithrombins; Arginine; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Female; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Whole Blood Coagulation Time | 2013 |
[Open heart surgery using cardiopulmonary bypass in a patient with heparin-induced thrombocytopenia(HIT)].
Topics: Aged; Arginine; Cardiopulmonary Bypass; Coronary Artery Bypass; Coronary Stenosis; Heparin; Humans; Male; Mitral Valve; Mitral Valve Insufficiency; Pipecolic Acids; Platelet Aggregation Inhibitors; Sulfonamides; Thrombocytopenia | 2013 |
Non-recovery of ACT in a patient with heparin-induced thrombocytopenia type II during mitral valve replacement using argatroban anticoagulation.
Topics: Aged; Anticoagulants; Arginine; Blood Coagulation; Cardiopulmonary Bypass; Female; Heart Valve Prosthesis Implantation; Heparin; Humans; Mitral Valve; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Whole Blood Coagulation Time | 2013 |
Direct thrombin inhibitors and factor xa inhibitors can influence the diluted prothrombin time used as the initial screen for lupus anticoagulant.
Topics: Anticoagulants; Antithrombins; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Enoxaparin; Factor Xa Inhibitors; False Positive Reactions; Fondaparinux; Heparitin Sulfate; Hirudins; Humans; Lupus Coagulation Inhibitor; Mass Screening; Pipecolic Acids; Polysaccharides; Prothrombin Time; Recombinant Proteins; Sulfonamides; Thrombin | 2013 |
Heparin-induced thrombocytopenia.
Topics: Anticoagulants; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Heparin; Heparitin Sulfate; Humans; Pipecolic Acids; Platelet Aggregation Inhibitors; Platelet Count; Sulfonamides; Thrombocytopenia; Venous Thrombosis | 2013 |
Crystallographic, spectroscopic, and theoretical investigation of the efficiently separated 21R and 21S-diastereoisomers of argatroban.
Topics: Arginine; Computer Simulation; Crystallography, X-Ray; Magnetic Resonance Spectroscopy; Models, Molecular; Pipecolic Acids; Stereoisomerism; Sulfonamides; Thermodynamics | 2013 |
ROCK mediates the inflammatory response in thrombin induced microglia.
Topics: Amides; Animals; Antithrombins; Arginine; Cells, Cultured; Cerebral Cortex; Fluorescein; Fluorescent Dyes; Inflammation; Microglia; Microspheres; Nitric Oxide; Phagocytosis; Pipecolic Acids; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Sulfonamides; Thrombin; Tumor Necrosis Factor-alpha | 2013 |
A comparison of methods for estimating glomerular filtration rate for a population in Hawai'i with non-valvular atrial fibrillation.
Topics: Aged, 80 and over; Anticoagulants; Arginine; Asian People; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Dabigatran; Female; Glomerular Filtration Rate; Hawaii; Humans; Male; Morpholines; Pipecolic Acids; Retrospective Studies; Rivaroxaban; Sulfonamides; Thiophenes; Warfarin | 2013 |
Role of argatroban during neurointerventional procedures in patients with heparin induced thrombocytopenia.
Topics: Anticoagulants; Antithrombins; Arginine; Cerebral Angiography; Cerebrovascular Disorders; Combined Modality Therapy; Endovascular Procedures; Heparin; Humans; Pipecolic Acids; Sulfonamides; Thrombocytopenia | 2014 |
Neuroprotective effects of argatroban and C5a receptor antagonist (PMX53) following intracerebral haemorrhage.
Topics: Animals; Apoptosis; Arginine; Brain Edema; Cerebral Hemorrhage; Complement C5a; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuroprotective Agents; Peptides, Cyclic; Pipecolic Acids; Platelet Aggregation Inhibitors; Receptor, Anaphylatoxin C5a; RNA, Messenger; Stroke; Sulfonamides; Tubulin | 2014 |
Determination of inhibitory potency of argatroban toward thrombin by electrophoretically mediated microanalysis.
Topics: Antithrombins; Arginine; Blood Coagulation; Chromatography, Micellar Electrokinetic Capillary; Chromogenic Compounds; Dipeptides; Electrophoresis, Capillary; Enzyme Assays; Humans; Kinetics; Pipecolic Acids; Solutions; Sulfonamides; Thrombin | 2013 |
Intravenous warfarin and heparin-induced thrombocytopenia: making the diagnosis, management, modern monitoring, and multidisciplinary care.
Topics: Aged; Anticoagulants; Antithrombins; Arginine; Cardiac Surgical Procedures; Hemorrhage; Heparin; Humans; Infusions, Intravenous; Male; Pipecolic Acids; Pulmonary Embolism; Sulfonamides; Thrombocytopenia; Thrombosis; Warfarin | 2014 |
Investigation of effect of edaravone on ischemic stroke.
Topics: Adult; Aged; Aged, 80 and over; Antipyrine; Arginine; Edaravone; Female; Free Radical Scavengers; Humans; Ischemia; Male; Methacrylates; Middle Aged; Pipecolic Acids; Retrospective Studies; Risk Factors; Stroke; Sulfonamides; Young Adult | 2013 |
Severe decrease of cyclosporine levels in a heart transplant recipient receiving the direct thrombin inhibitor argatroban.
Topics: Antithrombins; Arginine; Creatinine; Cyclosporine; Cytochrome P-450 CYP3A Inducers; Drug Antagonism; Heart Transplantation; Humans; Immunosuppressive Agents; Middle Aged; Pipecolic Acids; Sulfonamides; Transplant Recipients | 2014 |
Dabigatran, rivaroxaban, apixaban, argatroban and fondaparinux and their effects on coagulation POC and platelet function tests.
Topics: Anticoagulants; Arginine; Artifacts; Benzimidazoles; beta-Alanine; Blood Coagulation; Dabigatran; Fondaparinux; Humans; Morpholines; Pipecolic Acids; Platelet Function Tests; Point-of-Care Systems; Polysaccharides; Pyrazoles; Pyridones; Rivaroxaban; Sulfonamides; Thiophenes; Thrombelastography; Whole Blood Coagulation Time | 2014 |
The dosing and monitoring of argatroban for heparin-induced thrombocytopenia during extracorporeal membrane oxygenation: a word of caution.
Topics: Adult; Antithrombins; Arginine; Extracorporeal Membrane Oxygenation; Female; Heparin; Humans; Pipecolic Acids; Sulfonamides; Thrombocytopenia | 2014 |
Direct thrombin inhibitor argatroban reduces stroke damage in 2 different models.
Topics: Animals; Arginine; Brain; Brain Ischemia; Learning Curve; Male; Maze Learning; Pipecolic Acids; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Stroke; Sulfonamides; Thrombin | 2014 |
Use of argatroban: experiences in continuous renal replacement therapy in critically ill patients after cardiac surgery.
Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Anticoagulants; APACHE; Arginine; Biomarkers; Blood Transfusion; Cardiac Surgical Procedures; Critical Illness; Drug Substitution; Female; Hemoglobins; Heparin; Hospital Mortality; Humans; Male; Middle Aged; Pipecolic Acids; Postoperative Hemorrhage; Renal Dialysis; Risk Factors; Sulfonamides; Time Factors; Treatment Outcome | 2014 |
Thrombosis of biatrial appendages due to heparin-induced thrombocytopenia.
Topics: Aged, 80 and over; Antibodies; Anticoagulants; Arginine; Arterial Occlusive Diseases; Atrial Appendage; Atrial Fibrillation; Biomarkers; Coronary Artery Bypass; Drug Administration Schedule; Drug Substitution; Female; Heart Diseases; Heparin; Humans; Pipecolic Acids; Sulfonamides; Thrombectomy; Thrombocytopenia; Thrombosis; Tomography, X-Ray Computed | 2013 |
Heparin-induced thrombocytopenia and the health economic analysis of argatroban.
Topics: Arginine; Cost-Benefit Analysis; Drug Costs; Fibrinolytic Agents; Heparin; Humans; Pipecolic Acids; Platelet Aggregation Inhibitors; Sulfonamides; Thrombocytopenia; United Kingdom | 2014 |
Concomitant use of argatroban and warfarin during hemodialysis in heparin-induced thrombocytopenia.
Topics: Anticoagulants; Arginine; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Polycystic Kidney Diseases; Renal Dialysis; Sulfonamides; Thrombocytopenia; Warfarin | 2015 |
Simultaneous comparison of thrombogenic reactions to different combinations of anticoagulants, activated clotting times, and materials.
Topics: Acrylates; Anticoagulants; Arginine; beta-Thromboglobulin; Blood Coagulation; Coated Materials, Biocompatible; Female; Heparin; Humans; Male; Pipecolic Acids; Platelet Aggregation Inhibitors; Platelet Factor 4; Polymers; Polyvinyl Chloride; Sulfonamides; Whole Blood Coagulation Time | 2014 |
Mannose-binding lectin promotes local microvascular thrombosis after transient brain ischemia in mice.
Topics: Animals; Antithrombins; Arginine; Brain Ischemia; Cerebrovascular Circulation; Disease Models, Animal; Fibrinogen; Infarction, Middle Cerebral Artery; Magnetic Resonance Imaging; Male; Mannose-Binding Lectin; Mice; Mice, Inbred C57BL; Mice, Knockout; Microcirculation; Pipecolic Acids; Reperfusion Injury; Sulfonamides; Thrombosis | 2014 |
Comparison of the aPTT with alternative tests for monitoring direct thrombin inhibitors in patient samples.
Topics: Antithrombins; Arginine; Benzimidazoles; beta-Alanine; Blood Coagulation; Blood Coagulation Tests; Dabigatran; Drug Monitoring; Heparin; Hirudins; Humans; Partial Thromboplastin Time; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombin; Thrombin Time; Thromboplastin | 2014 |
[Recipient of living kidney transplantation during which heparin-induced thrombocytopenia (HIT) was suspected: a case report].
Topics: Aged; Anesthesia, General; Anticoagulants; Antithrombins; Arginine; Diabetic Nephropathies; Drug Substitution; Female; Heparin; Humans; Kidney Transplantation; Living Donors; Perioperative Care; Pipecolic Acids; Postoperative Complications; Sulfonamides; Thrombocytopenia; Thromboembolism; Treatment Outcome | 2014 |
Use of argatroban and catheter-directed thrombolysis with alteplase in an oncology patient with heparin-induced thrombocytopenia with thrombosis.
Topics: Antithrombins; Arginine; Autografts; Catheterization; Drug Therapy, Combination; Fibrinolytic Agents; Heparin; Humans; Male; Middle Aged; Peripheral Blood Stem Cell Transplantation; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Thrombolytic Therapy; Tissue Plasminogen Activator; Venous Thrombosis | 2014 |
Bivalirudin for the treatment of patients with confirmed or suspected heparin-induced thrombocytopenia.
Topics: Adult; Aged; Anticoagulants; Antithrombins; Arginine; Female; Heparin; Heparin, Low-Molecular-Weight; Hirudins; Humans; Male; Middle Aged; Odds Ratio; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Registries; Retrospective Studies; Sulfonamides; Thrombocytopenia; Treatment Outcome | 2014 |
Interactions of some commonly used drugs with human α-thrombin.
Topics: Antithrombins; Arginine; Azlocillin; Humans; Kinetics; Metolazone; Molecular Docking Simulation; Molecular Structure; Pipecolic Acids; Piperacillin; Protein Binding; Protein Structure, Tertiary; Sulfonamides; Thrombin | 2015 |
Changes of proteins induced by anticoagulants can be more sensitively detected in urine than in plasma.
Topics: Animals; Anticoagulants; Arginine; Biomarkers; Blotting, Western; Chromatography, Liquid; Female; Heparin; Injections, Intravenous; Pipecolic Acids; Proteins; Proteome; Proteomics; Rats, Sprague-Dawley; Sulfonamides; Tandem Mass Spectrometry | 2014 |
The effect of a polyurethane coating incorporating both a thrombin inhibitor and nitric oxide on hemocompatibility in extracorporeal circulation.
Topics: Animals; Antithrombins; Arginine; Blood Coagulation; Blood Platelets; Coated Materials, Biocompatible; Extracorporeal Circulation; Isocyanates; Nitric Oxide; Pipecolic Acids; Platelet Activation; Platelet Function Tests; Polyethylene Glycols; Polymers; Polyurethanes; Rabbits; Sulfonamides; Thrombin; Thrombosis | 2014 |
Heparin-induced thrombocytopenia in haemodialysis treated with argatroban.
Topics: Aged; Antithrombins; Arginine; Heparin; Humans; Male; Pipecolic Acids; Renal Dialysis; Sulfonamides; Thrombocytopenia | 2014 |
Progressive, Fatal Thrombosis Associated With Heparin-Induced Thrombocytopenia After Cardiac Surgery Despite "Therapeutic" Anticoagulation With Argatroban: Potential Role for PTT and ACT Confounding.
Topics: Adult; Antithrombins; Aortic Valve Stenosis; Arginine; Fatal Outcome; Fibrinolytic Agents; Heart Valve Prosthesis Implantation; Heparin; Humans; Infusions, Intravenous; Male; Partial Thromboplastin Time; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Thrombosis; Whole Blood Coagulation Time | 2015 |
Trends in parenteral direct thrombin inhibitor use in pediatric patients: analysis of a large administrative database.
Topics: Adolescent; Age Factors; Antithrombins; Arginine; Child; Child, Preschool; Databases, Factual; Female; Health Information Systems; Hemorrhage; Hirudins; Humans; Incidence; Infant; Infant, Newborn; Infusions, Parenteral; Male; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Retrospective Studies; Sulfonamides; Thrombocytopenia; Young Adult | 2014 |
The paradoxical antifibrinolytic effect of dabigatran and argatroban in the presence of soluble thrombomodulin is unrelated to protein C-dependent increase of thrombin generation.
Topics: Antithrombins; Arginine; Benzimidazoles; beta-Alanine; Carboxypeptidase B2; Dabigatran; Fibrinolysis; Humans; Pipecolic Acids; Protein C; Sulfonamides; Thrombin; Thrombomodulin | 2014 |
Activated protein C resistance testing for factor V Leiden.
Topics: Activated Protein C Resistance; Adult; Antithrombins; Arginine; Benzimidazoles; beta-Alanine; Biological Assay; Blood Coagulation Tests; Child; Dabigatran; Factor V; Factor Xa; False Positive Reactions; Female; Hirudins; Humans; Lupus Coagulation Inhibitor; Morpholines; Peptide Fragments; Pipecolic Acids; Pregnancy; Protein C; Recombinant Proteins; Rivaroxaban; Sulfonamides; Thiophenes; Warfarin | 2014 |
Compatibility of argatroban injection with select antiarrhythmic drugs.
Topics: Anti-Arrhythmia Agents; Antithrombins; Arginine; Chemistry, Pharmaceutical; Drug Incompatibility; Injections; Pipecolic Acids; Spectrophotometry, Ultraviolet; Sulfonamides | 2014 |
[Lateral medullary infarction presenting with truncal lateropulsion and decreased pain and temperature sensation below T10 sensory level].
Topics: Antipyrine; Arginine; Cerebral Infarction; Clopidogrel; Drug Therapy, Combination; Edaravone; Free Radical Scavengers; Humans; Lateral Medullary Syndrome; Magnetic Resonance Imaging; Male; Medulla Oblongata; Middle Aged; Pipecolic Acids; Platelet Aggregation Inhibitors; Somatosensory Disorders; Sulfonamides; Ticlopidine; Treatment Outcome; Vertebral Artery Dissection | 2014 |
Urine reflection of changes in blood.
Topics: Animals; Anticoagulants; Arginine; Biomarkers; Blood Proteins; Chromatography, Liquid; Female; Heparin; Humans; Pipecolic Acids; Proteome; Proteomics; Rats; Rats, Sprague-Dawley; Sulfonamides; Tandem Mass Spectrometry | 2015 |
Management of intraoperative free flap arterial thrombosis with argatroban in the heparin-allergic patient.
Topics: Anticoagulants; Antithrombins; Arginine; Drug Hypersensitivity; Female; Free Tissue Flaps; Heparin; Humans; Intraoperative Complications; Middle Aged; Pipecolic Acids; Sulfonamides; Thrombosis | 2014 |
Pulmonary embolism and heparin-induced thrombocytopenia successfully treated with tissue plasminogen activator and argatroban.
Topics: Antithrombins; Arginine; Female; Fibrinolytic Agents; Heparin; Humans; Middle Aged; Pipecolic Acids; Pulmonary Embolism; Sulfonamides; Thrombocytopenia; Tissue Plasminogen Activator | 2015 |
[Case of spontaneous cervical internal carotid artery dissection with embolic stroke after a job-change].
Topics: Antipyrine; Arginine; Carotid Artery, Internal, Dissection; Diagnosis, Differential; Edaravone; Humans; Infarction, Middle Cerebral Artery; Intracranial Embolism; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Male; Middle Aged; Personnel Turnover; Pipecolic Acids; Platelet Aggregation Inhibitors; Stress, Psychological; Stroke; Sulfonamides; Workload; Workplace | 2014 |
Efficacy and safety of argatroban and bivalirudine in patients with suspected heparin-induced thrombocytopenia.
Topics: Aged; Anticoagulants; Arginine; Female; Hemorrhage; Heparin; Hirudins; Humans; Male; Middle Aged; Partial Thromboplastin Time; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Retrospective Studies; Sulfonamides; Thrombocytopenia | 2015 |
Efficacy of argatroban in critically ill patients with heparin resistance: a retrospective analysis.
Topics: Anticoagulants; Antithrombin III; Arginine; Critical Illness; Drug Resistance; Female; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Platelet Aggregation Inhibitors; Retrospective Studies; Sulfonamides | 2015 |
Synthesis and Biological Evaluation of Some New 2,5-Substituted 1-Ethyl-1H-benzoimidazole Fluorinated Derivatives as Direct Thrombin Inhibitors.
Topics: Antithrombins; Arginine; Benzimidazoles; Blood Coagulation; Dabigatran; Dose-Response Relationship, Drug; Drug Design; Humans; Hydrocarbons, Fluorinated; Molecular Docking Simulation; Molecular Structure; Pipecolic Acids; Structure-Activity Relationship; Sulfonamides | 2015 |
Safety and economic considerations of argatroban use in critically ill patients: a retrospective analysis.
Topics: Adult; Aged; Anticoagulants; Arginine; Critical Illness; Dose-Response Relationship, Drug; Drug Costs; Female; Germany; Health Care Costs; Hemorrhage; Heparin; Humans; Intensive Care Units; Male; Middle Aged; Pipecolic Acids; Retrospective Studies; Sulfonamides; Thrombocytopenia; Thromboembolism | 2015 |
Design, synthesis, and anti-thrombotic evaluation of some novel fluorinated thrombin inhibitor derivatives.
Topics: Antithrombins; Arginine; Binding Sites; Carbon-13 Magnetic Resonance Spectroscopy; Computer-Aided Design; Drug Design; Halogenation; Humans; Mass Spectrometry; Molecular Docking Simulation; Pipecolic Acids; Propionates; Protein Binding; Protein Conformation; Proton Magnetic Resonance Spectroscopy; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Structure-Activity Relationship; Sulfonamides; Thrombin | 2015 |
Evaluation of a multi-target direct thrombin inhibitor dosing and titration guideline for patients with suspected heparin-induced thrombocytopenia.
Topics: Aged; Aged, 80 and over; Antithrombins; Arginine; Drug Administration Schedule; Drug Dosage Calculations; Drug Monitoring; Female; Heparin; Hirudins; Humans; Male; Middle Aged; Peptide Fragments; Pipecolic Acids; Practice Guidelines as Topic; Prospective Studies; Recombinant Proteins; Sulfonamides; Survival Analysis; Thrombocytopenia; Treatment Outcome | 2015 |
Implantation of left ventricular assist devices under extracorporeal life support in patients with heparin-induced thrombocytopenia.
Topics: Acute Disease; Adult; Aged; Anticoagulants; Arginine; Cohort Studies; Extracorporeal Circulation; Female; Heart Failure; Heart-Assist Devices; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Prosthesis Implantation; Sulfonamides; Thrombocytopenia; Thrombosis | 2015 |
A new weighted balance measure helped to select the variables to be included in a propensity score model.
Topics: Acute Disease; Arginine; Bias; Cohort Studies; Computer Simulation; Continuous Positive Airway Pressure; Data Collection; France; Heart Failure; Hospital Mortality; Humans; Intensive Care Units; Mean Platelet Volume; Models, Statistical; Monte Carlo Method; Observational Studies as Topic; Outcome Assessment, Health Care; Pipecolic Acids; Propensity Score; Sulfonamides | 2015 |
Minimal Prolongation of Prothrombin Time with Extended Exposure to Argatroban.
Topics: Anticoagulants; Antithrombins; Arginine; Carcinoma, Squamous Cell; Drug Substitution; Female; Heparin; Humans; International Normalized Ratio; Mandibular Neoplasms; Middle Aged; Mouth Mucosa; Pipecolic Acids; Prothrombin Time; Sulfonamides; Syndrome; Thrombocytopenia; Thrombosis; Treatment Failure; Warfarin | 2015 |
Comparison of bivalirudin to lepirudin and argatroban in patients with heparin-induced thrombocytopenia.
Topics: Aged; Anticoagulants; Antithrombins; Arginine; Dose-Response Relationship, Drug; Female; Hemorrhage; Heparin; Hirudins; Humans; International Normalized Ratio; Male; Middle Aged; Partial Thromboplastin Time; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Retrospective Studies; Sulfonamides; Thrombocytopenia | 2015 |
Limitation of the activated partial thromboplastin time as a monitoring method of the direct thrombin inhibitor argatroban.
Topics: Antithrombins; Arginine; Blood Coagulation; Dose-Response Relationship, Drug; Humans; Partial Thromboplastin Time; Pipecolic Acids; Reproducibility of Results; Sulfonamides | 2015 |
Concentration-Dependent Dual Role of Thrombin in Protection of Cultured Rat Cortical Neurons.
Topics: Animals; Antithrombin III; Aprotinin; Arginine; Cell Survival; Cells, Cultured; Cerebral Cortex; Neurites; Neurons; Neuroprotective Agents; Peptide Fragments; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Receptor, PAR-1; Receptors, Thrombin; Sulfonamides; Thrombin | 2015 |
[Monitoring of 4 patients with heparin-induced thrombocytopenia after complex congenital heart surgery].
Topics: Anticoagulants; Arginine; Cardiac Surgical Procedures; Heparin; Humans; Incidence; Infant; Pipecolic Acids; Platelet Count; Prognosis; Sulfonamides; Thrombocytopenia; Thrombosis | 2015 |
Early recognition is the key to success: pulseless electrical activity (PEA) as a manifestation of heparin-induced anaphylactoid reaction.
Topics: Anticoagulants; Arginine; Arrhythmias, Cardiac; Cardiopulmonary Resuscitation; Early Diagnosis; Heart Valve Prosthesis Implantation; Heparin; Humans; Male; Middle Aged; Mitral Valve; Pipecolic Acids; Platelet Count; Platelet Function Tests; Sulfonamides; Thrombocytopenia; Treatment Outcome | 2015 |
Aptamer-Based Enzyme Capture Assay for Measurement of Plasma Thrombin Levels.
Topics: Antithrombins; Aptamers, Nucleotide; Arginine; Enzyme Assays; Humans; Pipecolic Acids; Sulfonamides; Thrombin | 2016 |
Identification of a degrading enzyme in human serum that hydrolyzes a C-terminal core sequence of neuromedin U.
Topics: Amino Acid Chloromethyl Ketones; Arginine; Humans; Hydrolysis; Neuropeptides; Pipecolic Acids; Serum; Sulfonamides; Thrombin | 2016 |
Outcomes of Argatroban Treatment in Patients With Atherothrombotic Stroke: Observational Nationwide Study in Japan.
Topics: Adult; Aged; Aged, 80 and over; Antithrombins; Arginine; Case-Control Studies; Cohort Studies; Female; Hemorrhage; Humans; Intracranial Arteriosclerosis; Intracranial Thrombosis; Japan; Male; Middle Aged; Odds Ratio; Pipecolic Acids; Practice Guidelines as Topic; Retrospective Studies; Stroke; Sulfonamides; Treatment Outcome | 2016 |
Challenging Argatroban Management of a Child on Extracorporeal Support and Subsequent Heart Transplant.
Topics: Antithrombins; Arginine; Cardiopulmonary Bypass; Child; Exchange Transfusion, Whole Blood; Extracorporeal Membrane Oxygenation; Heart Transplantation; Heparin; Hirudins; Humans; Male; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2016 |
Evaluation of anticoagulant effects of direct thrombin inhibitors, dabigatran and argatroban, based on the Lineweaver-Burk plot applied to the Clauss assay.
Topics: Antithrombins; Arginine; Blood Coagulation; Dabigatran; Humans; Kinetics; Pipecolic Acids; Sulfonamides | 2016 |
Heparin-Induced-Thrombocytopenia Causing Massive Aortic Thrombosis after Ascending Aortic Replacement for Type A Acute Aortic Dissection.
Topics: Acute Disease; Aged; Anticoagulants; Aortic Aneurysm; Aortic Diseases; Aortic Dissection; Aortography; Arginine; Blood Vessel Prosthesis Implantation; Computed Tomography Angiography; Drug Substitution; Emergencies; Fatal Outcome; Female; Gastrointestinal Hemorrhage; Heparin; Humans; Mesenteric Ischemia; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Thrombosis; Time Factors; Treatment Outcome | 2016 |
Argatroban monitoring: aPTT versus chromogenic assay.
Topics: Arginine; Blood Coagulation; Blood Coagulation Tests; Drug Monitoring; Humans; Partial Thromboplastin Time; Pipecolic Acids; Platelet Aggregation Inhibitors; Sulfonamides; Thrombocytopenia | 2016 |
Evaluation of Argatroban as a Potential Anticoagulant for Clinical Laboratory Analysis: Precision, Stability and Interference Study.
Topics: Adult; Anticoagulants; Arginine; Edetic Acid; Erythrocyte Indices; Female; Humans; Male; Pipecolic Acids; Sulfonamides | 2016 |
Combined factor IIa and Xa inhibitor therapy for thrombosis whilst on therapeutic anticoagulant.
Topics: Adult; Aged; Anticoagulants; Antithrombins; Arginine; Dabigatran; Factor Xa Inhibitors; Female; Heparin, Low-Molecular-Weight; Humans; Male; Middle Aged; Neoplasms; Pipecolic Acids; Pyrazoles; Pyridones; Recurrence; Rivaroxaban; Sulfonamides; Venous Thrombosis | 2016 |
Effect of Thrombin Inhibitors on Positive Feedback in the Coagulation Cascade.
Topics: Antithrombins; Arginine; Blood Coagulation Tests; Feedback, Physiological; Hirudins; Humans; Kinetics; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombin | 2016 |
Argatroban more effectively inhibits the thrombin activity in synovial fluid than naturally occurring thrombin inhibitors.
Topics: Aged; Aged, 80 and over; Antithrombins; Arginine; Blood Coagulation; Cytokines; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Models, Biological; Pipecolic Acids; Sulfonamides; Synovial Fluid; Thrombin; Thromboplastin | 2016 |
Dabigatran and Argatroban Diametrically Modulate Thrombin Exosite Function.
Topics: Allosteric Regulation; Antithrombins; Arginine; Binding Sites; Biocatalysis; Blood Coagulation; Catalytic Domain; Dabigatran; Fibrin; Fibrinogen; Humans; Pipecolic Acids; Protein Binding; Substrate Specificity; Sulfonamides; Surface Plasmon Resonance; Thrombin | 2016 |
Argatroban for anticoagulation of a blood salvage system - an ex-vivo study.
Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Arginine; Blood Coagulation; Blood Transfusion; Dose-Response Relationship, Drug; Female; Hematocrit; Heparin; Humans; In Vitro Techniques; Male; Middle Aged; Operative Blood Salvage; Pipecolic Acids; Sulfonamides; Thrombocytopenia | 2016 |
A novel, rapid method to compare the therapeutic windows of oral anticoagulants using the Hill coefficient.
Topics: Administration, Oral; Anticoagulants; Arginine; Blood Coagulation; Blood Platelets; Dose-Response Relationship, Drug; Fluorometry; Fondaparinux; Humans; Inhibitory Concentration 50; Pipecolic Acids; Plasma; Polysaccharides; Sulfonamides; Thrombin | 2016 |
Argatroban for Treatment of Heparin-Induced Thrombocytopenia and Thrombosis in a Patient with Multiple Myeloma Undergoing Hemodialysis.
Topics: Aged, 80 and over; Anticoagulants; Antithrombins; Arginine; Dalteparin; Female; Humans; Multiple Myeloma; Partial Thromboplastin Time; Pipecolic Acids; Renal Dialysis; Sulfonamides; Thrombocytopenia; Venous Thrombosis | 2016 |
Overtreatment of Heparin-Induced Thrombocytopenia in the Surgical ICU.
Topics: Academic Medical Centers; Aged; Antibodies; Anticoagulants; Antithrombins; Arginine; Enzyme-Linked Immunosorbent Assay; Female; Fondaparinux; Heparin; Hirudins; Humans; Intensive Care Units; Male; Medical Overuse; Middle Aged; Pipecolic Acids; Platelet Factor 4; Polysaccharides; Prospective Studies; Recombinant Proteins; Serotonin; Sulfonamides; Thrombocytopenia | 2017 |
Successful Anticoagulation Using Argatroban During Transcatheter Aortic Valve Implantation in a Patient With Heparin-Induced Thrombocytopenia.
Topics: Aged, 80 and over; Anticoagulants; Arginine; Heparin; Humans; Male; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Transcatheter Aortic Valve Replacement | 2016 |
Dual functionalized poly(vinylidene fluoride) membrane with acryloylmorpholine and argatroban to improve antifouling and hemocompatibility.
Topics: Arginine; Female; Humans; Male; Materials Testing; Membranes, Artificial; Morpholines; Partial Thromboplastin Time; Pipecolic Acids; Polyvinyls; Sulfonamides; Thrombin Time | 2017 |
Photodegradation of aqueous argatroban investigated by LC/MS
Topics: Arginine; Chromatography, Reverse-Phase; Mass Spectrometry; Photolysis; Pipecolic Acids; Sulfonamides | 2016 |
Monitoring anticoagulation with argatroban in critically ill patients: activated partial thromboplastin time versus diluted thrombin time.
Topics: Anticoagulants; Arginine; Critical Illness; Humans; Partial Thromboplastin Time; Pipecolic Acids; Sulfonamides; Thrombin Time; Thrombocytopenia | 2016 |
[Intraluminal Thrombus in Internal Carotid Artery Successfully Treated with Adjuvant Anticoagulant Therapy Followed by Carotid Endarterectomy:A Case Report].
Topics: Aged; Antithrombins; Arginine; Carotid Artery, Internal; Carotid Stenosis; Cerebral Angiography; Endarterectomy, Carotid; Female; Humans; Magnetic Resonance Angiography; Pipecolic Acids; Sulfonamides; Tomography, X-Ray Computed; Treatment Outcome | 2016 |
Recurrent heparin-induced thrombocytopenia due to heparin rinsing before priming the machine in a hemodialysis patient: A case report.
Topics: Aged, 80 and over; Anticoagulants; Arginine; Female; Heparin; Humans; Pipecolic Acids; Renal Dialysis; Sulfonamides; Thrombocytopenia | 2017 |
Further evidence of the limitations of Activated Partial Thromboplastin Time to monitor Argatroban.
Topics: Arginine; Blood Coagulation; Drug Monitoring; Humans; Partial Thromboplastin Time; Pipecolic Acids; Platelet Aggregation Inhibitors; Sulfonamides | 2018 |
Biodegradable polymer-based, argatroban-eluting, cobalt-chromium stent (JF-04) for treatment of native coronary lesions: final results of the first-in-man study and lessons learned.
Topics: Absorbable Implants; Adult; Aged; Aged, 80 and over; Arginine; Chromium; Coronary Angiography; Coronary Artery Disease; Coronary Restenosis; Coronary Stenosis; Coronary Vessels; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Pipecolic Acids; Sulfonamides; Treatment Outcome | 2016 |
Rapid and durable response to intravenous immunoglobulin in delayed heparin-induced thrombocytopenia: a case report.
Topics: Arginine; Cardiac Surgical Procedures; Heparin; Hirudins; Humans; Immunoglobulins, Intravenous; Male; Middle Aged; Peptide Fragments; Pipecolic Acids; Postoperative Complications; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Thrombosis | 2017 |
Heparin-induced thrombocytopenia with aortoiliac thrombosis treated with argatroban.
Topics: Anticoagulants; Antithrombins; Aortic Diseases; Arginine; Heparin; Humans; Iliac Artery; Male; Middle Aged; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Thrombosis | 2017 |
Monitoring of Argatroban and Lepirudin: What is the Input of Laboratory Values in "Real Life"?
Topics: Antithrombins; Arginine; Blood Coagulation Tests; Drug Monitoring; Heparin; Hirudins; Humans; Partial Thromboplastin Time; Pipecolic Acids; Prothrombin Time; Recombinant Proteins; Sulfonamides; Thrombin Time; Thrombocytopenia | 2018 |
Local Intraluminal Irrigation With Argatroban During Free Flap Repair in a Patient With Heparin-Induced Thrombocytopenia.
Topics: Arginine; Carcinoma, Squamous Cell; Female; Forearm; Free Tissue Flaps; Head and Neck Neoplasms; Humans; Middle Aged; Mouth Neoplasms; Neck Dissection; Pipecolic Acids; Platelet Aggregation Inhibitors; Radial Artery; Sulfonamides; Treatment Outcome | 2017 |
Use of an argatroban-based purge solution in a percutaneous ventricular assist device.
Topics: Aged; Anticoagulants; Arginine; Blood Coagulation; Drug Substitution; Female; Heart-Assist Devices; Heparin; Humans; Pipecolic Acids; Shock, Cardiogenic; Sulfonamides; Takotsubo Cardiomyopathy; Thrombocytopenia; Treatment Outcome | 2017 |
Anticoagulation in children: Making the most of little patients and little evidence.
Topics: Anticoagulants; Arginine; Blood Coagulation; Child; Drug Monitoring; Fondaparinux; Heparin; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Sulfonamides; Thrombosis; Venous Thromboembolism; Warfarin | 2017 |
Response to: "More on the Limitations of the aPTT for Monitoring Argatroban Therapy".
Topics: Anticoagulants; Arginine; Heparin; Humans; Partial Thromboplastin Time; Pipecolic Acids; Sulfonamides; Thrombocytopenia | 2017 |
More on the Limitations of the Activated Partial Thromboplastin Time for Monitoring Argatroban Therapy.
Topics: Anticoagulants; Arginine; Heparin; Humans; Partial Thromboplastin Time; Pipecolic Acids; Sulfonamides; Thrombocytopenia | 2017 |
The Use of Eptifibatide Alone or in Combination With Heparin or Argatroban for Suspected Thrombosis in Patients With Left Ventricular Assist Devices.
Topics: Adult; Aged; Anticoagulants; Arginine; Eptifibatide; Female; Heart Failure; Heart-Assist Devices; Hemolysis; Heparin; Humans; Male; Middle Aged; Peptides; Pipecolic Acids; Platelet Aggregation Inhibitors; Retrospective Studies; Sulfonamides; Thrombosis; Warfarin; Young Adult | 2017 |
Argatroban for Heparin-Induced Thrombocytopenia during Venovenous Extracorporeal Membrane Oxygenation with Continuous Venovenous Hemofiltration.
Topics: Adult; Anticoagulants; Antithrombins; Arginine; Dose-Response Relationship, Drug; Extracorporeal Membrane Oxygenation; Hemofiltration; Heparin; Humans; Male; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Thrombosis; Treatment Outcome | 2017 |
Safety and effectiveness of argatroban versus heparin for preventing venous thromboembolism after lumbar decompressive surgery.
Topics: Adult; Aged; Anticoagulants; Arginine; Decompression, Surgical; Female; Heparin; Heparin, Low-Molecular-Weight; Humans; Incidence; Lumbar Vertebrae; Male; Middle Aged; Pipecolic Acids; Platelet Aggregation Inhibitors; Postoperative Complications; Quality of Life; Retrospective Studies; Sulfonamides; Venous Thromboembolism; Venous Thrombosis | 2017 |
Argatroban Attenuates Diabetic Cardiomyopathy in Rats by Reducing Fibrosis, Inflammation, Apoptosis, and Protease-Activated Receptor Expression.
Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Fibrosis; Heart; Inflammation; Male; Myocardium; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Receptors, Proteinase-Activated; Signal Transduction; Sulfonamides | 2017 |
Treatment of pulmonary embolism with argatroban and ultrasound-assisted catheter-directed thrombolysis with alteplase in a patient with heparin-induced thrombocytopenia.
Topics: Aged; Arginine; Catheterization; Drug Therapy, Combination; Female; Fibrinolytic Agents; Heparin; Humans; Pipecolic Acids; Platelet Aggregation Inhibitors; Pulmonary Embolism; Sulfonamides; Thrombocytopenia; Thrombolytic Therapy; Tissue Plasminogen Activator; Treatment Outcome; Ultrasonography, Interventional | 2017 |
Response by Barreto and Grotta to Letter Regarding Article, "Randomized, Multicenter Trial of ARTSS-2 (Argatroban With Recombinant Tissue Plasminogen Activator for Acute Stroke)".
Topics: Arginine; Brain Ischemia; Fibrinolytic Agents; Humans; Pipecolic Acids; Recombinant Proteins; Stroke; Sulfonamides; Tissue Plasminogen Activator; Treatment Outcome | 2017 |
Letter by Shah Regarding Article, "Randomized, Multicenter Trial of ARTSS-2 (Argatroban With Recombinant Tissue Plasminogen Activator for Acute Stroke)".
Topics: Arginine; Brain Ischemia; Fibrinolytic Agents; Humans; Pipecolic Acids; Recombinant Proteins; Stroke; Sulfonamides; Tissue Plasminogen Activator; Treatment Outcome | 2017 |
Argatroban in Thrombocytopenic Patients Sensitized to Circulating Protamine-Heparin Complexes.
Topics: Adult; Arginine; Autoantibodies; Extracorporeal Membrane Oxygenation; Female; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Platelet Aggregation Inhibitors; Protamines; Sulfonamides; Thrombocytopenia | 2017 |
Influences of argatroban on five fibrinogen assays.
Topics: Adult; Arginine; Blood Coagulation; Blood Coagulation Tests; Female; Fibrinogen; Humans; Male; Pipecolic Acids; Sulfonamides | 2017 |
Thrombolysis for acute pulmonary embolism after major hepatic surgery.
Topics: Acute Disease; Adenocarcinoma; Appendiceal Neoplasms; Arginine; Atrial Fibrillation; Bronchoscopy; Catheters; Colectomy; Computed Tomography Angiography; Diagnosis, Differential; Electric Countershock; Fibrinolytic Agents; Heparin; Hepatectomy; Humans; Infusions, Intravenous; Intubation, Intratracheal; Liver Neoplasms; Lung; Male; Middle Aged; Pipecolic Acids; Postoperative Complications; Pulmonary Embolism; Sulfonamides; Thrombocytopenia; Thrombolytic Therapy; Tissue Plasminogen Activator; Troponin I; Ultrasonography; Venous Thrombosis | 2017 |
Anticoagulation of Percutaneous Ventricular Assist Device Using Argatroban-Based Purge Solution: A Case Series.
Topics: Aged, 80 and over; Anticoagulants; Arginine; Blood Coagulation; Drug Monitoring; Female; Heart-Assist Devices; Heparin; Humans; Male; Middle Aged; Pharmaceutical Solutions; Pipecolic Acids; Platelet Aggregation Inhibitors; Sulfonamides; Thrombocytopenia | 2018 |
Dual-target inhibitor screening against thrombin and factor Xa simultaneously by mass spectrometry.
Topics: Anticoagulants; Arginine; Drug Evaluation, Preclinical; Factor Xa; Factor Xa Inhibitors; Pipecolic Acids; Rivaroxaban; Sulfonamides; Tandem Mass Spectrometry; Thrombin | 2017 |
Idiopathic catastrophic thrombosis with happy ending.
Topics: Anticoagulants; Antithrombins; Arginine; Awareness; Blood Coagulation Tests; Coronary Artery Bypass; Heparin; Humans; Male; Middle Aged; Phenprocoumon; Pipecolic Acids; Platelet Aggregation Inhibitors; ST Elevation Myocardial Infarction; Sulfonamides; Thrombocytopenia; Thrombosis; Treatment Outcome; Ultrasonography; Venous Thrombosis | 2017 |
Cerebral Venous Sinus Thrombosis Due to Low-molecular-weight Heparin-induced Thrombocytopenia.
Topics: Anticoagulants; Arginine; Female; Heparin, Low-Molecular-Weight; Humans; Middle Aged; Pipecolic Acids; Platelet Count; Sulfonamides; Thrombocytopenia; Thrombosis; Venous Thrombosis | 2017 |
Protease-activated receptor 1 inhibition protects mice against thrombin-dependent respiratory syncytial virus and human metapneumovirus infections.
Topics: Animals; Arginine; Cells, Cultured; Female; Humans; Indazoles; Metapneumovirus; Mice; Oligopeptides; Paramyxoviridae Infections; Pipecolic Acids; Receptor, PAR-1; Respiratory Syncytial Virus, Human; Sulfonamides; Thrombin; Urea; Virus Replication; Weight Loss | 2018 |
Situational Awareness and Patient Safety.
Topics: Adult; Antiphospholipid Syndrome; Antithrombins; Arginine; Awareness; Female; Gastrointestinal Hemorrhage; Humans; Liver Cirrhosis; Male; Medication Errors; Middle Aged; Occult Blood; Patient Safety; Pipecolic Acids; Sulfonamides | 2017 |
Use of Fondaparinux Off-Label or Approved Anticoagulants for Management of Heparin-Induced Thrombocytopenia.
Topics: Anticoagulants; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Factor Xa Inhibitors; Female; Fondaparinux; Hemorrhage; Heparin; Heparitin Sulfate; Hirudins; Hospital Mortality; Hospitalization; Humans; Male; Necrosis; Off-Label Use; Partial Thromboplastin Time; Patient Safety; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Registries; Retrospective Studies; Sulfonamides; Thrombocytopenia; Thromboembolism; Treatment Outcome | 2017 |
Phenolic fractions from nine Trifolium species modulate the coagulant properties of blood plasma in vitro without cytotoxicity towards blood cells.
Topics: Arginine; Blood Coagulation; Blood Platelets; Cell Survival; Coagulants; Dose-Response Relationship, Drug; Humans; Phenols; Pipecolic Acids; Plant Components, Aerial; Plant Extracts; Sulfonamides; Trifolium | 2018 |
Heparin-Induced Thrombocytopenia during Obstetric Hospital Admissions.
Topics: Adolescent; Adult; Arginine; Databases, Factual; Delivery, Obstetric; Female; Fondaparinux; Heparin; Heparin, Low-Molecular-Weight; Hirudins; Hospitalization; Humans; Middle Aged; Peptide Fragments; Pipecolic Acids; Postpartum Period; Pregnancy; Recombinant Proteins; Risk Assessment; Sulfonamides; Thrombocytopenia; United States; Young Adult | 2018 |
Heparin-Induced Thrombocytopenia in Infants after Heart Surgery.
Topics: Antibodies; Anticoagulants; Antithrombins; Arginine; Blood Coagulation; Blood Coagulation Tests; Cardiac Surgical Procedures; Drug Monitoring; Female; Heart Defects, Congenital; Heparin; Humans; Infant; Male; Pipecolic Acids; Platelet Factor 4; Predictive Value of Tests; Risk Factors; Sulfonamides; Thrombocytopenia; Treatment Outcome | 2019 |
Retrospective Analysis of Argatroban in 353 Patients with Acute Noncardioembolic Stroke.
Topics: Aged; Aged, 80 and over; Antithrombins; Arginine; Brain Ischemia; Female; Fibrinolytic Agents; Humans; Male; Methacrylates; Middle Aged; Pipecolic Acids; Prognosis; Retrospective Studies; Severity of Illness Index; Stroke; Sulfonamides | 2018 |
Argatroban is stable in citrated whole blood for 24 hours.
Topics: Arginine; Blood; Citrates; Drug Stability; Humans; Pipecolic Acids; Platelet Aggregation Inhibitors; Sulfonamides; Temperature; Time Factors | 2018 |
Synthesis and biocompatibility of an argatroban-modified polysulfone membrane that directly inhibits thrombosis.
Topics: Adsorption; Adult; Anticoagulants; Arginine; Blood Coagulation; Blood Coagulation Tests; Humans; Hydrophobic and Hydrophilic Interactions; Male; Materials Testing; Membranes, Artificial; Pipecolic Acids; Platelet Adhesiveness; Polymers; Renal Dialysis; Sulfonamides; Sulfones; Thrombosis | 2018 |
[Safety of Dual Antiplatelet Therapy with Argatroban in Patients with Acute Ischemic Stroke].
Topics: Arginine; Brain Ischemia; Drug Therapy, Combination; Humans; Ischemic Attack, Transient; Pipecolic Acids; Platelet Aggregation Inhibitors; Retrospective Studies; Stroke; Sulfonamides | 2018 |
Self-assembled, bivalent aptamers on graphene oxide as an efficient anticoagulant.
Topics: Adsorption; Animals; Anticoagulants; Aptamers, Nucleotide; Arginine; Binding, Competitive; Blood Coagulation; DNA, Single-Stranded; Graphite; Heparin; Hirudins; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Male; Oxides; Pipecolic Acids; Protein Binding; Rats; Rats, Sprague-Dawley; Sulfonamides; Thrombin | 2018 |
In vitro effects of a kaolin-coated hemostatic dressing on anticoagulated blood.
Topics: Adult; Anticoagulants; Antithrombins; Arginine; Bandages; Blood Coagulation; Blood Coagulation Tests; Dabigatran; Factor Xa Inhibitors; Hemostatics; Heparin; Humans; Kaolin; Pipecolic Acids; Platelet Aggregation Inhibitors; Prospective Studies; Rivaroxaban; Sulfonamides; Viscoelastic Substances; Vitamin K | 2018 |
Comparison of argatroban and fondaparinux for the management of patients with isolated heparin-induced thrombocytopenia.
Topics: Aged; Arginine; Fondaparinux; Heparin; Humans; Middle Aged; Pipecolic Acids; Retrospective Studies; Sulfonamides; Thrombocytopenia; Thromboembolism | 2018 |
An infrequent complication of a not so infrequent disease. Hit by HIT.
Topics: Acute Coronary Syndrome; Aged; Anticoagulants; Antithrombins; Aortic Valve; Arginine; Drug Substitution; Echocardiography, Transesophageal; Electrocardiography; Extracorporeal Membrane Oxygenation; Fatal Outcome; Heart Arrest; Heart Valve Prosthesis; Heart Valve Prosthesis Implantation; Heparin; Humans; Male; Pipecolic Acids; Sulfonamides; Thrombectomy; Thrombocytopenia; Thrombosis; Treatment Outcome | 2019 |
Transverse diffusion of laminar flow profiles as a generic capillary electrophoresis method for in-line nanoreactor mixing: Application to the investigation of antithrombotic activity.
Topics: Arginine; Benzamidines; Chromogenic Compounds; Electrophoresis, Capillary; Fibrinolytic Agents; Humans; Limit of Detection; Oligopeptides; Pipecolic Acids; Pyrrolidonecarboxylic Acid; Small Molecule Libraries; Sulfonamides; Thrombin | 2018 |
Argatroban plus aspirin versus aspirin in acute ischemic stroke.
Topics: Arginine; Aspirin; Brain Ischemia; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Male; Pipecolic Acids; Platelet Aggregation Inhibitors; Retrospective Studies; Severity of Illness Index; Statistics as Topic; Stroke; Sulfonamides; Treatment Outcome | 2018 |
Evaluation of anticoagulant agents for the treatment of human metapneumovirus infection in mice.
Topics: Animals; Anticoagulants; Arginine; Disease Models, Animal; Heparin; Metapneumovirus; Mice; Paramyxoviridae Infections; Pipecolic Acids; Sulfonamides; Survival Analysis; Treatment Outcome; Viral Load; Virus Replication; Warfarin | 2018 |
Prevalence and outcome of heparin-induced thrombocytopenia diagnosed under veno-arterial extracorporeal membrane oxygenation: a retrospective nationwide study.
Topics: Adult; Aged; Anticoagulants; Arginine; Critical Care; Diagnosis, Differential; Extracorporeal Membrane Oxygenation; Female; France; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Platelet Aggregation Inhibitors; Platelet Count; Prevalence; Retrospective Studies; Shock, Cardiogenic; Sulfonamides; Thrombocytopenia; Treatment Outcome | 2018 |
Safety and Feasibility of Argatroban, Recombinant Tissue Plasminogen Activator, and Intra-Arterial Therapy in Stroke (ARTSS-IA Study).
Topics: Aged; Aged, 80 and over; Arginine; Cerebral Hemorrhage; Combined Modality Therapy; Drug Therapy, Combination; Endovascular Procedures; Feasibility Studies; Fibrinolytic Agents; Humans; Incidence; Middle Aged; Pipecolic Acids; Platelet Aggregation Inhibitors; Postoperative Complications; Stroke; Sulfonamides; Thrombolytic Therapy; Tissue Plasminogen Activator; Treatment Outcome | 2018 |
Reversible Auricular Necrosis Secondary to Systemic Thrombosis.
Topics: Anticoagulants; Antiphospholipid Syndrome; Arginine; Ear Auricle; Ear Diseases; Female; Heparin; Humans; Necrosis; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Thrombosis | 2018 |
Use of argatroban for extracorporeal life support in patients with nonheparin-induced thrombocytopenia: Analysis of 10 consecutive patients.
Topics: Adult; Antithrombins; Arginine; Blood Coagulation Tests; Drug Monitoring; Extracorporeal Membrane Oxygenation; Female; Heparin; Humans; Male; Middle Aged; Patient Care Management; Pipecolic Acids; Platelet Count; Republic of Korea; Retrospective Studies; Sulfonamides; Thrombocytopenia; Treatment Outcome | 2018 |
American Society of Hematology 2018 guidelines for management of venous thromboembolism: heparin-induced thrombocytopenia.
Topics: Administration, Oral; Anticoagulants; Arginine; Cardiovascular Surgical Procedures; Chondroitin Sulfates; Dermatan Sulfate; Evidence-Based Medicine; Fondaparinux; Heparin; Heparitin Sulfate; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Platelet Count; Recombinant Proteins; Renal Replacement Therapy; Sulfonamides; Thrombocytopenia; Venous Thromboembolism | 2018 |
Thrombosis in the portal venous system caused by hypereosinophilic syndrome: A case report.
Topics: Arginine; Critical Illness; Drug Therapy, Combination; Fibrinolytic Agents; Gastrointestinal Hemorrhage; Heparin; Humans; Hypereosinophilic Syndrome; Male; Pipecolic Acids; Plasma Exchange; Platelet Aggregation Inhibitors; Portal System; Pulmonary Eosinophilia; Sulfonamides; Tissue Plasminogen Activator; Tomography, X-Ray Computed; Urokinase-Type Plasminogen Activator; Venous Thrombosis; Young Adult | 2018 |
A 24-hour perioperative case study on argatroban use for left ventricle assist device insertion during cardiopulmonary bypass and veno-arterial extracorporeal membrane oxygenation.
Topics: Adult; Arginine; Extracorporeal Membrane Oxygenation; Heart-Assist Devices; Humans; Male; Perioperative Care; Pipecolic Acids; Platelet Aggregation Inhibitors; Sulfonamides; Time Factors | 2019 |
Thrombin contributes to the injury development and neurological deficit after acute subdural hemorrhage in rats only in collaboration with additional blood-derived factors.
Topics: Animals; Arginine; Dose-Response Relationship, Drug; Fibrinolytic Agents; Hematoma, Subdural, Acute; Male; Motor Skills; Pipecolic Acids; Protein Serine-Threonine Kinases; Pyrroles; Quinazolines; Random Allocation; Rats, Sprague-Dawley; Severity of Illness Index; Sulfonamides; Thrombin | 2018 |
Development of a stent capable of the controlled release of basic fibroblast growth factor and argatroban to treat cerebral aneurysms: In vitro experiment and evaluation in a rabbit aneurysm model.
Topics: Animals; Arginine; Delayed-Action Preparations; Disease Models, Animal; Drug-Eluting Stents; Female; Fibroblast Growth Factor 2; Intracranial Aneurysm; Pipecolic Acids; Rabbits; Sulfonamides | 2019 |
High-dose intravenous immunoglobulin to treat spontaneous heparin-induced thrombocytopenia syndrome.
Topics: Anticoagulants; Arginine; Arthroplasty, Replacement, Knee; Female; Fondaparinux; Gastrointestinal Hemorrhage; Heparin; Humans; Immunoglobulins, Intravenous; Middle Aged; Pipecolic Acids; Platelet Activation; Platelet Count; Serotonin; Sulfonamides; Thrombocytopenia; Thrombosis; Venous Thromboembolism | 2019 |
Sepsis-induced heparin resistance during extracorporeal membrane oxygenation.
Topics: Adult; Anticoagulants; Antithrombins; Arginine; Drug Resistance; Extracorporeal Membrane Oxygenation; Female; Heparin; Humans; Pipecolic Acids; Sepsis; Sulfonamides; Thrombocytopenia | 2019 |
High frequency of false-positive results of aPTT-based lupus anticoagulant tests in patients receiving argatroban.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arginine; Female; Heparin; Humans; Lupus Coagulation Inhibitor; Male; Middle Aged; Partial Thromboplastin Time; Pipecolic Acids; Sulfonamides; Thrombocytopenia | 2019 |
Immobilizing argatroban and mPEG-NH
Topics: Adult; Anticoagulants; Arginine; Blood; Blood Coagulation; Coated Materials, Biocompatible; Female; Fibrinolytic Agents; Humans; Indoles; Membranes, Artificial; Pipecolic Acids; Platelet Adhesiveness; Polyethylene Glycols; Polymers; Sulfonamides; Sulfones; Surface Properties | 2019 |
Lipopolysaccharide-Induced Hemolysis Is Abolished by Inhibition of Thrombin Generation but Not Inhibition of Platelet Aggregation.
Topics: Animals; Arginine; Disseminated Intravascular Coagulation; Eptifibatide; Erythrocyte Membrane; Erythrocytes; Hemolysis; Humans; Lipopolysaccharides; Male; Pipecolic Acids; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Sulfonamides; Thrombin | 2019 |
Inpatient management strategies in a severe case of heparin-induced thrombocytopenia.
Topics: Aged; Arginine; Coronary Artery Bypass; Female; Fondaparinux; Heparin; Humans; Pipecolic Acids; Platelet Count; Platelet Transfusion; Sulfonamides; Thrombocytopenia; Venous Thrombosis | 2019 |
A novel simultaneous clot-fibrinolysis waveform analysis for assessing fibrin formation and clot lysis in haemorrhagic disorders.
Topics: Arginine; Fibrin; Fibrin Clot Lysis Time; Fibrinolysis; Hemorrhagic Disorders; Humans; Kinetics; Pipecolic Acids; Sulfonamides; Thrombomodulin; Tranexamic Acid | 2019 |
Application of thrombelastography in primary total knee and total hip replacement: a prospective 87 patients study.
Topics: Anticoagulants; Arginine; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Female; Humans; Male; Middle Aged; Partial Thromboplastin Time; Perioperative Care; Pipecolic Acids; Postoperative Care; Preoperative Care; Prospective Studies; Prothrombin Time; Pulmonary Embolism; Rivaroxaban; Sulfonamides; Thrombelastography; Thrombophilia; Venous Thrombosis | 2019 |
Successful intravenous administration of argatroban in the management of heparin-resistant and surgery-resistant mesenteric vein thrombosis.
Topics: Administration, Intravenous; Aged; Antithrombins; Arginine; Female; Humans; Mesenteric Vascular Occlusion; Mesenteric Veins; Pipecolic Acids; Portal Vein; Splenic Vein; Sulfonamides; Treatment Outcome; Venous Thrombosis | 2019 |
Safety and Feasibility of Using Argatroban Immediately After Mechanical Thrombectomy for Large Artery Occlusion.
Topics: Adult; Aged; Arginine; Cerebral Arterial Diseases; Female; Humans; Male; Mechanical Thrombolysis; Middle Aged; Pipecolic Acids; Platelet Aggregation Inhibitors; Retrospective Studies; Stroke; Sulfonamides | 2019 |
Evaluation of intravenous direct thrombin inhibitor monitoring tests: Correlation with plasma concentrations and clinical outcomes in hospitalized patients.
Topics: Adult; Aged; Antithrombins; Arginine; Female; Hirudins; Hospitalization; Humans; Infusions, Intravenous; Male; Middle Aged; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombin; Thrombin Time; Treatment Outcome | 2020 |
Argatroban to achieve therapeutic anticoagulation in two patients with acute thrombosis and heparin resistance.
Topics: Acute Disease; Adult; Anticoagulants; Arginine; Drug Resistance; Female; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Sulfonamides; Thrombosis | 2019 |
Argatroban Versus Bivalirudin in the Treatment of Suspected or Confirmed Heparin-Induced Thrombocytopenia.
Topics: Anticoagulants; Arginine; Heparin; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Retrospective Studies; Sulfonamides; Thrombocytopenia; Treatment Outcome | 2021 |
Preoperative and intraoperative argatroban as anticoagulant for bridging a patient with heparin-induced thrombocytopaenia to lung transplantation.
Topics: Aged; Anticoagulants; Arginine; Heparin; Humans; Lung Transplantation; Male; Pipecolic Acids; Sulfonamides; Thrombocytopenia | 2020 |
Early Identification of Argatroban Resistance and the Consideration of Factor VIII.
Topics: Aged; Anticoagulants; Arginine; Factor VIII; Female; Heparin; Humans; Percutaneous Coronary Intervention; Pipecolic Acids; Sulfonamides | 2021 |
Effect of emicizumab on global coagulation assays for plasma supplemented with apixaban or argatroban.
Topics: Antibodies, Bispecific; Antibodies, Monoclonal, Humanized; Arginine; Hemophilia A; Humans; Partial Thromboplastin Time; Pipecolic Acids; Plasma; Pyrazoles; Pyridones; Sulfonamides | 2020 |
Survey of Anticoagulation Practices with the Impella Percutaneous Ventricular Assist Device at High-Volume Centers.
Topics: Anticoagulants; Arginine; Heart-Assist Devices; Heparin; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Practice Patterns, Physicians'; Recombinant Proteins; Sulfonamides; Surveys and Questionnaires; United States | 2019 |
Bivalirudin resistance in a patient on veno-venous extracorporeal membrane oxygenation with a therapeutic response to argatroban.
Topics: Anticoagulants; Arginine; Combined Modality Therapy; Drug Resistance; Extracorporeal Membrane Oxygenation; Hirudins; Humans; Male; Middle Aged; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Respiratory Insufficiency; Sulfonamides | 2020 |
Bleeding complications after cardiac surgery, before anticoagulation start and then with argatroban or heparin in the early postoperative setting.
Topics: Aged; Anticoagulants; Arginine; Cardiac Surgical Procedures; Critical Illness; Elective Surgical Procedures; Erythrocyte Transfusion; Female; Hemoglobins; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Postoperative Hemorrhage; Retrospective Studies; Sulfonamides; Time-to-Treatment | 2020 |
An online dual-enzyme co-immobilized microreactor based on capillary electrophoresis for enzyme kinetics assays and screening of dual-target inhibitors against thrombin and factor Xa.
Topics: Arginine; Catechin; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Electrophoresis, Capillary; Enzyme Activation; Enzyme Assays; Enzyme Inhibitors; Enzymes, Immobilized; Factor Xa; Kinetics; Molecular Docking Simulation; Pipecolic Acids; Rivaroxaban; Sulfonamides; Thrombin | 2020 |
Responsiveness of the activated partial thromboplastin time and dilute thrombin time to argatroban: Results of an in vitro study.
Topics: Antithrombins; Arginine; Female; Humans; Male; Partial Thromboplastin Time; Pipecolic Acids; Sulfonamides; Thrombin Time | 2020 |
Argatroban dosing requirements in extracorporeal life support and other critically ill populations.
Topics: Anticoagulants; Arginine; Cohort Studies; Critical Illness; Extracorporeal Membrane Oxygenation; Heparin; Humans; Pipecolic Acids; Retrospective Studies; Sulfonamides; Thrombocytopenia | 2020 |
Lung transplantation using argatroban in severe heparin-induced thrombocytopenia during extracorporeal membrane oxygenation: a case series.
Topics: Anticoagulants; Arginine; Extracorporeal Membrane Oxygenation; Heparin; Humans; Lung Transplantation; Pipecolic Acids; Sulfonamides; Thrombocytopenia | 2020 |
Myocardial Infarction with Limb Arterial and Venous Thrombosis in a Patient with Enoxaparin-Induced Thrombocytopenia.
Topics: Aged; Antithrombins; Arginine; Enoxaparin; Factor Xa Inhibitors; Female; Humans; Pipecolic Acids; Pyrazoles; Pyridones; ST Elevation Myocardial Infarction; Sulfonamides; Thrombocytopenia; Thrombosis | 2020 |
Thrombocytopenia and Thromboses in Myocardial Infarction Associated with Eptifibatide-Dependent Activating Antiplatelet Antibodies.
Topics: Antigens, Human Platelet; Arginine; Aspirin; Autoantibodies; Combined Modality Therapy; Coronary Thrombosis; Drug Substitution; Drug Therapy, Combination; Eptifibatide; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Pipecolic Acids; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Transfusion; Purpura, Thrombocytopenic, Idiopathic; Shock, Cardiogenic; ST Elevation Myocardial Infarction; Stents; Sulfonamides; Thrombectomy; Thrombolytic Therapy; Thrombosis; Ticagrelor; Warfarin | 2020 |
Argatroban as Purge Solution in Patients With Heparin-Induced Thrombocytopenia on an Impella Device.
Topics: Anticoagulants; Arginine; Heparin; Humans; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Treatment Outcome | 2020 |
Anticoagulation with argatroban in patients with acute antithrombin deficiency in severe COVID-19.
Topics: Acute Disease; Adult; Anticoagulants; Antithrombins; Arginine; Betacoronavirus; Cohort Studies; Coronavirus Infections; COVID-19; Female; Humans; Incidence; Male; Middle Aged; Pandemics; Pipecolic Acids; Pneumonia, Viral; SARS-CoV-2; Severity of Illness Index; Sulfonamides; Thrombophilia | 2020 |
MRG15 orchestrates rhythmic epigenomic remodelling and controls hepatic lipid metabolism.
Topics: Animals; Arginine; Cell Line; Chromosomal Proteins, Non-Histone; Circadian Rhythm; Epigenesis, Genetic; Epigenomics; Fatty Liver; Glucose Tolerance Test; Histones; Humans; Lipid Metabolism; Liver; Male; Mice; Mice, Inbred C57BL; Pipecolic Acids; Receptors, Cytoplasmic and Nuclear; RNA Polymerase II; Sulfonamides; Trans-Activators | 2020 |
Utilization and Outcomes of Children Treated with Direct Thrombin Inhibitors on Paracorporeal Ventricular Assist Device Support.
Topics: Adolescent; Antithrombins; Arginine; Child; Child, Preschool; Female; Heart-Assist Devices; Hemorrhage; Hirudins; Humans; Infant; Male; North America; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Retrospective Studies; Stroke; Sulfonamides; Thrombosis; Treatment Outcome | 2020 |
Argatroban therapy for heparin-induced thrombocytopenia in a patient with coronavirus disease 2019.
Topics: Adult; Anticoagulants; Antithrombins; Arginine; Betacoronavirus; Blood Coagulation; Coronavirus Infections; COVID-19; Heparin; Host-Pathogen Interactions; Humans; Male; Pandemics; Pipecolic Acids; Pneumonia, Viral; Pulmonary Embolism; SARS-CoV-2; Sulfonamides; Thrombocytopenia; Treatment Outcome | 2020 |
Thrombolysis and use of argatroban for the treatment of massive pulmonary embolism following anticoagulation failure in a patient with COVID-19.
Topics: Adult; Anticoagulants; Arginine; Coronavirus Infections; COVID-19; Fibrinolytic Agents; Heart Arrest; Heparin, Low-Molecular-Weight; Humans; Male; Pandemics; Pipecolic Acids; Pneumonia, Viral; Pulmonary Embolism; Sulfonamides; Thrombolytic Therapy; Treatment Failure; Treatment Outcome | 2020 |
Argatroban for therapeutic anticoagulation for heparin resistance associated with Covid-19 infection.
Topics: Adult; Anticoagulants; Arginine; Catheter Obstruction; COVID-19; Drug Resistance; Drug Substitution; Fibrin Fibrinogen Degradation Products; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Pulmonary Embolism; Respiration, Artificial; SARS-CoV-2; Sulfonamides; Thrombosis; Tomography, X-Ray Computed; Treatment Outcome | 2021 |
Unexpectedly Low Fibrinogen.
Topics: Antithrombins; Arginine; Blood Chemical Analysis; Fibrinogen; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Sulfonamides; Thrombocytopenia | 2020 |
Aortic Arch Thrombus and Pulmonary Embolism in a COVID-19 Patient.
Topics: Anticoagulants; Antithrombins; Aorta, Thoracic; Arginine; Biomarkers; COVID-19; Female; Heparin; Humans; Middle Aged; Pipecolic Acids; Pneumonia, Viral; Pulmonary Embolism; SARS-CoV-2; Sulfonamides; Thrombosis | 2021 |
Anticoagulation Strategies and Filter Life in COVID-19 Patients Receiving Continuous Renal Replacement Therapy: A Single-Center Experience.
Topics: Acute Kidney Injury; Aged; Anticoagulants; Arginine; Citric Acid; Continuous Renal Replacement Therapy; COVID-19; Disposable Equipment; Equipment Failure; Female; Heparin, Low-Molecular-Weight; Humans; Male; Middle Aged; Pipecolic Acids; SARS-CoV-2; Sulfonamides; Time Factors | 2020 |
Early and long-term outcomes of argatroban use in patients with acute noncardioembolic stroke.
Topics: Aged; Arginine; Brain Ischemia; Endovascular Procedures; Female; Humans; Male; Middle Aged; Pipecolic Acids; Platelet Aggregation Inhibitors; Retrospective Studies; Stroke; Sulfonamides; Treatment Outcome | 2020 |
Emergent Carotid Artery Stenting Following Intravenous Alteplase Infusion After Rapid Negative Diagnosis for COVID-19 by Loop-Mediated Isothermal Amplification Assay.
Topics: Aged; Arginine; Carotid Stenosis; Combined Modality Therapy; COVID-19; Fibrinolytic Agents; Hemiplegia; Humans; Ischemic Stroke; Magnetic Resonance Imaging; Male; Molecular Diagnostic Techniques; Nucleic Acid Amplification Techniques; Pipecolic Acids; Platelet Aggregation Inhibitors; Stents; Sulfonamides; Tissue Plasminogen Activator; Tomography, X-Ray Computed; Treatment Outcome | 2021 |
[Examination of the Relationship between Worse Symptom and Differences Route during Administration of Argatroban in Acute Ischemic Stroke Patients].
Topics: Administration, Intravenous; Aged; Aged, 80 and over; Arginine; Drug Administration Routes; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Patient Outcome Assessment; Pipecolic Acids; Retrospective Studies; Safety; Stroke; Sulfonamides; Symptom Flare Up | 2020 |
Comparison of different anticoagulation strategies for renal replacement therapy in critically ill patients with COVID-19: a cohort study.
Topics: Acute Kidney Injury; Adult; Aged; Anticoagulants; Arginine; Betacoronavirus; Blood Coagulation; Citric Acid; Comorbidity; Coronavirus Infections; COVID-19; Critical Care; Critical Illness; Equipment Failure; Female; Germany; Heparin; Heparin, Low-Molecular-Weight; Humans; Male; Middle Aged; Pandemics; Pipecolic Acids; Pneumonia, Viral; Renal Replacement Therapy; Retrospective Studies; SARS-CoV-2; Sulfonamides; Tertiary Care Centers | 2020 |
[Complex management of type 2 heparin-induced thrombocytopenia in patients with major bleeding tendency: two case report].
Topics: 4-Hydroxycoumarins; Aged; Anticoagulants; Arginine; Blood Coagulation Disorders; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Hemorrhage; Heparin; Humans; Indenes; Intracranial Thrombosis; Male; Middle Aged; Neurosurgical Procedures; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Vitamin K | 2020 |
Thrombin inhibitor argatroban modulates bone marrow stromal cells behaviors and promotes osteogenesis through canonical Wnt signaling.
Topics: Alveolar Bone Loss; Animals; Antithrombins; Arginine; Cell Differentiation; Cell Proliferation; Cells, Cultured; Male; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Osteogenesis; Periodontitis; Pipecolic Acids; Sulfonamides; Thrombin; Wnt Signaling Pathway | 2021 |
Treatment and outcomes of heparin-induced thrombocytopenia (HIT) in patients with neoplasm, a case series.
Topics: Aged; Anticoagulants; Arginine; Canada; Female; Fondaparinux; Gastrointestinal Neoplasms; Hematologic Neoplasms; Hemorrhage; Heparin; Humans; Male; Patient Acuity; Pipecolic Acids; Platelet Count; Retrospective Studies; Risk Adjustment; Sulfonamides; Thrombocytopenia | 2021 |
A case report of successful transition from argatroban to warfarin using DOAC-stop in heparin induced thrombocytopenia (HIT).
Topics: Aged; Anticoagulants; Arginine; Heparin; Humans; Male; Pipecolic Acids; Platelet Aggregation Inhibitors; Sulfonamides; Thrombocytopenia; Warfarin | 2021 |
The Effects of the Combined Argatroban/Nitric Oxide-Releasing Polymer on Platelet Microparticle-Induced Thrombogenicity in Coated Extracorporeal Circuits.
Topics: Animals; Antithrombins; Arginine; Blood Platelets; Cell-Derived Microparticles; Extracorporeal Circulation; Nitric Oxide; Pipecolic Acids; Platelet Activation; Polymers; Rabbits; Sulfonamides; Thrombosis | 2021 |
Argatroban versus heparin in patients without heparin-induced thrombocytopenia during venovenous extracorporeal membrane oxygenation: a propensity-score matched study.
Topics: Adult; Anticoagulants; Antithrombins; Arginine; Equivalence Trials as Topic; Extracorporeal Membrane Oxygenation; Female; Germany; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Propensity Score; Prospective Studies; Registries; Sulfonamides; Thrombocytopenia | 2021 |
Using Nonheparin Anticoagulant to Treat a Near-Fatal Case With Multiple Venous Thrombotic Lesions During ChAdOx1 nCoV-19 Vaccination-Related Vaccine-Induced Immune Thrombotic Thrombocytopenia.
Topics: Antithrombins; Arginine; Cerebral Veins; ChAdOx1 nCoV-19; COVID-19 Vaccines; Drug Therapy, Combination; Female; Fondaparinux; Humans; Immunoglobulins, Intravenous; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Tomography, X-Ray Computed; Venous Thrombosis; Young Adult | 2021 |
SARS-CoV-2 vaccine-induced immune thrombotic thrombocytopenia treated with immunoglobulin and argatroban.
Topics: Antithrombins; Arginine; COVID-19; COVID-19 Vaccines; Female; Humans; Immunoglobulins, Intravenous; Immunologic Factors; Middle Aged; Pipecolic Acids; Purpura, Thrombocytopenic; SARS-CoV-2; Sulfonamides | 2021 |
Use of an argatroban systemic infusion and purge solution in a patient with a percutaneous ventricular assist device with suspected heparin-induced thrombocytopenia.
Topics: Adult; Arginine; Heart-Assist Devices; Humans; Pipecolic Acids; Sulfonamides; Thrombocytopenia | 2022 |
Dabigatran Use after Argatroban for Heparin-induced Thrombocytopenia with Thrombosis: A Case Series and Literature Review.
Topics: Aged; Anticoagulants; Antithrombins; Arginine; Dabigatran; Drug Therapy, Combination; Fatal Outcome; Female; Gastrointestinal Hemorrhage; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Platelet Count; Sulfonamides; Thrombocytopenia; Venous Thrombosis | 2022 |
Rivaroxaban and apixaban for the treatment of suspected or confirmed heparin-induced thrombocytopenia.
Topics: Adult; Aged; Arginine; Factor Xa Inhibitors; Female; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Pyrazoles; Pyridones; Retrospective Studies; Rivaroxaban; Sulfonamides; Thrombocytopenia | 2022 |
Early argatroban and antiplatelet combination therapy in acute non-lacunar single subcortical infarct associated with mild intracranial atherosclerosis.
Topics: Arginine; Drug Therapy, Combination; Humans; Intracranial Arteriosclerosis; Pipecolic Acids; Platelet Aggregation Inhibitors; Stroke, Lacunar; Sulfonamides; Treatment Outcome | 2021 |
Use of Argatroban in Donor Lung Procurement: A Case Report.
Topics: Anticoagulants; Arginine; Heparin; Humans; Lung; Pipecolic Acids; Sulfonamides | 2021 |
Laboratory methods for monitoring argatroban in heparin-induced thrombocytopenia.
Topics: Anticoagulants; Arginine; COVID-19; Drug Monitoring; Heparin; Humans; Partial Thromboplastin Time; Pipecolic Acids; Sulfonamides; Thrombocytopenia | 2022 |
Development and validation of an analytical method for the determination of direct oral anticoagulants (DOAC) and the direct thrombin-inhibitor argatroban by HPLC-MS/MS.
Topics: Administration, Oral; Aged; Anticoagulants; Antithrombins; Arginine; Chromatography, High Pressure Liquid; Dabigatran; Humans; Pipecolic Acids; Pyridones; Rivaroxaban; Sulfonamides; Tandem Mass Spectrometry; Thrombin | 2022 |
Dual Antiplatelet Therapy Plus Argatroban Prevents Early Neurological Deterioration in Branch Atherosclerosis Disease.
Topics: Arginine; Aspirin; Atherosclerosis; Brain Ischemia; Clopidogrel; Humans; Pipecolic Acids; Platelet Aggregation Inhibitors; Stroke; Sulfonamides; Ticlopidine | 2022 |
[Performance evaluation of the STA ECA-II reagent for specific assay of anti-IIa activity of argatroban].
Topics: Anticoagulants; Arginine; Heparin; Humans; Indicators and Reagents; Partial Thromboplastin Time; Pipecolic Acids; Reproducibility of Results; Sulfonamides | 2021 |
[Low-dose argatroban emerging salvage therapies for heparin-induced thrombocytopenia during artificial liver treatment: a case report].
Topics: Anticoagulants; Arginine; Heparin; Humans; Liver, Artificial; Pipecolic Acids; Salvage Therapy; Sulfonamides; Thrombocytopenia; Treatment Outcome | 2021 |
Papilledema due to Vaccine-Induced Thrombocytopenia.
Topics: Antithrombins; Arginine; ChAdOx1 nCoV-19; COVID-19; Female; Glucocorticoids; Humans; Hydrocortisone; Immunoglobulins, Intravenous; Middle Aged; Ophthalmoscopy; Papilledema; Pipecolic Acids; Purpura, Thrombocytopenic, Idiopathic; SARS-CoV-2; Sinus Thrombosis, Intracranial; Sulfonamides; Vaccination | 2022 |
Atrial Fibrillation in a Patient with Heparin-induced Thrombocytopenia Successfully Treated by Radiofrequency Catheter Ablation Using a Direct Thrombin Inhibitor.
Topics: Aged; Antithrombins; Arginine; Atrial Fibrillation; Catheter Ablation; Heparin; Humans; Male; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Treatment Outcome | 2022 |
A journey through anticoagulant therapies in the treatment of left ventricular thrombus in post-COVID-19 heparin-induced thrombocytopenia: a case report.
Topics: Acenocoumarol; Anticoagulants; Arginine; COVID-19; COVID-19 Drug Treatment; Heparin; Hirudins; Humans; Male; Middle Aged; Peptide Fragments; Percutaneous Coronary Intervention; Pipecolic Acids; Recombinant Proteins; SARS-CoV-2; Sulfonamides; Thrombocytopenia; Thrombosis | 2022 |
Managing argatroban in heparin-induced thrombocytopenia: A retrospective analysis of 729 treatment days in 32 patients with confirmed heparin-induced thrombocytopenia.
Topics: Anticoagulants; Arginine; Heparin; Humans; Pipecolic Acids; Retrospective Studies; Sulfonamides; Thrombocytopenia | 2022 |
How to dose and monitor argatroban for treatment of HIT.
Topics: Anticoagulants; Arginine; Heparin; Humans; Pipecolic Acids; Retrospective Studies; Sulfonamides; Thrombocytopenia | 2022 |
Impact of a commercially available DOAC absorbent on two integrated procedures for lupus anticoagulant detection in plasma containing argatroban.
Topics: Anticoagulants; Antiphospholipid Syndrome; Arginine; Humans; Lupus Coagulation Inhibitor; Pipecolic Acids; Sulfonamides | 2022 |
Use of the CytoSorb® filter for elimination of residual therapeutic argatroban concentrations during heparinized cardiopulmonary bypass for heart transplantation.
Topics: Adult; Anticoagulants; Arginine; Cardiopulmonary Bypass; Heart Transplantation; Heparin; Humans | 2023 |
Development of a carotid artery thrombolysis stroke model in mice.
Topics: Animals; Anticoagulants; Antithrombins; Arginine; Brain Ischemia; Carotid Artery, Common; Fibrinolytic Agents; Infarction, Middle Cerebral Artery; Ischemic Stroke; Mice; Pipecolic Acids; Stroke; Sulfonamides; Thromboembolism; Thrombolytic Therapy; Tissue Plasminogen Activator; Treatment Outcome | 2022 |
[Argatroban in patients with venovenous extracorporeal membrane oxygenation].
Topics: Arginine; Extracorporeal Membrane Oxygenation; Humans; Pipecolic Acids; Retrospective Studies; Sulfonamides | 2022 |