arginine has been researched along with heme in 353 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 46 (13.03) | 18.7374 |
| 1990's | 106 (30.03) | 18.2507 |
| 2000's | 136 (38.53) | 29.6817 |
| 2010's | 57 (16.15) | 24.3611 |
| 2020's | 8 (2.27) | 2.80 |
| Authors | Studies |
|---|---|
| Morgan, WT; Muller-eberhard, U | 1 |
| Dauter, Z; Oldfield, TJ; Petratos, K; Smerdon, SJ; Wilkinson, AJ; Wilson, KS | 1 |
| Kauma, H; Timonen, TT | 1 |
| Fitzsimons, E; Houston, T; Jamieson, A; Moore, MR | 1 |
| Go, M; Horiuchi, T; Koga, H; Noguti, T; Tsujimura, M; Yasukochi, T; Yoshikawa, K | 1 |
| Bray, RC; Burke, JF; Sanders, SA; Smith, AT; Thorneley, RN; Veitch, NC; Williams, RJ | 1 |
| Cutler, RL; Davies, AM; Greenwood, C; Mauk, AG; Moore, GR; Pielak, GJ; Smith, M; Thurgood, AG; Williamson, DJ | 1 |
| Ignarro, LJ | 1 |
| Dover, SB; Fitzsimons, E; Graham, A; McColl, KE; Moore, MR | 1 |
| Dugad, LB; Goff, HM; Lukat, GS; Wang, CC; Wang, X | 1 |
| Abraham, NG; Goodman, AI; Levere, RD; Martasek, P; Schwartzman, ML; Solangi, KB | 1 |
| Gray, TA; Manning, DJ | 1 |
| Goldberg, A; Herrick, AL; McColl, KE; Moore, MR; Wallace, AM | 1 |
| Abraham, NG; Escalante, B; Levere, RD; Martasek, P; Schwartzman, ML | 1 |
| Coletta, M; Kraut, J; Mauro, JM; Miller, MA; Smulevich, G; Traylor, TG | 1 |
| Lauharanta, J; Mustajoki, P; Tenhunen, R; Timonen, K | 1 |
| Abraham, NG; Lin, JH; Martasek, P; Villalon, P | 1 |
| Arnold, R; Beckh, K; Blanke, H; Doss, M; Sieg, I; Stellwaag, M | 1 |
| Green, D; Ts'ao, CH | 1 |
| Kordac, V; Kozáková, M; Martásek, P | 1 |
| Cook, A; Goldberg, A; Herrick, AL; McColl, KE; Moore, MR | 1 |
| Pierach, CA | 1 |
| Juvonen, E; Partanen, S; Ruutu, T; Tenhunen, R | 1 |
| Bianco, P; Bruschi, M; Cambillau, C; Dolla, A; Haladjian, J | 1 |
| Häkli, H; Luhtala, J; Sievers, G; Tenhunen, R | 1 |
| English, AM; Fishel, LA; Kraut, J; Mauro, JM; Smulevich, G; Spiro, TG | 1 |
| Karlsson, M; Lindén, IB; Tenhunen, R; Tokola, O | 1 |
| Brodie, MJ; Goldberg, A; Herrick, A; McColl, KE; McLellan, A; Moore, MR | 1 |
| Lindén, IB; Tenhunen, R; Tokola, O | 2 |
| Volin, L | 1 |
| Mustajoki, P; Tenhunen, R; Tokola, O; Volin, L | 2 |
| Bakchine, S; Derouesne, C; Fontaine, B; Laplane, D; Nordmann, Y | 1 |
| Kordac, V; Martásek, P | 2 |
| Cieslar, P; Kordac, V; Kornalík, F; Martásek, P; Spicka, I | 1 |
| Himberg, JJ; Mustajoki, P; Tokola, O | 1 |
| Rasi, V; Tenhunen, R; Vahtera, E; Volin, L | 1 |
| Knuutila, S; Ruutu, T; Tenhunen, R; Volin, L | 1 |
| Tokola, O | 2 |
| Ruutu, T; Tenhunen, R; Volin, L | 1 |
| Tenhunen, R | 1 |
| Bakken, AF; Schmid, R; Thaler, MM | 1 |
| Perutz, MF; TenEyck, LF | 1 |
| Acher, R; Chauvet, JP | 1 |
| Song, H; Swick, RW | 1 |
| Goz, B; Voytek, P | 1 |
| Hoober, JK; Stegeman, WJ | 1 |
| Ho, C; Ladner, JE; Perutz, MF; Simon, SR | 1 |
| Strauss, PR | 1 |
| Hutner, SH; Tamburro, KM | 1 |
| DeBernard, B; Druyan, R; Rabinowitz, M | 1 |
| Nakaya, K; Shibata, K; Suzuki, T; Takenaka, O | 1 |
| Barlow, GH; Campbell, LL; Drucker, H; Margoliash, E; Trousil, EB | 1 |
| Albin, R; Aschenbrenner, B; Druyan, R; Rabinowitz, M | 1 |
| de Bruin, SH; Janssen, LH; van Os, GA | 1 |
| Bock, KW; Siekevitz, P | 1 |
| Guerritore, D; Zito, R | 1 |
| Craigie, JS; Laycock, MV | 1 |
| Nanzyo, N; Sano, S | 1 |
| Hollender, A; Lehmann, H; Lorkin, PA; Svensson, B | 1 |
| Grayzel, AI; London, IM; Tavill, AS; Vanderhoff, GA | 1 |
| Frey, C; Griffith, OW; Masters, BS; McMillan, K; Salerno, JC; Williams, RF | 1 |
| Abu-Soud, HM; Stuehr, DJ | 1 |
| Gross, SS; Khatsenko, OG; Rifkind, AB; Vane, JR | 1 |
| Marletta, MA | 1 |
| Clark, P; Ikeda-Saito, M; Matsuoka, A; Olson, JS; Stuehr, DJ | 1 |
| Fukuto, JM; Griscavage, JM; Ignarro, LJ; Komori, Y | 1 |
| Frey, C; Griffith, OW; Gross, SS; Masters, BS; McMillan, K; Narayanan, K; Spack, L | 1 |
| Abu-Soud, HM; Rousseau, DL; Stuehr, DJ; Wang, J | 1 |
| Marletta, MA; Olken, NM; Osawa, Y | 1 |
| Abu-Soud, HM; Clark, P; Feldman, PL; Stuehr, DJ | 1 |
| Hurshman, AR; Marletta, MA | 2 |
| Meunier, B; Rich, PR; Rodriguez-Lopez, JN; Smith, AT; Thorneley, RN | 1 |
| Amada, F; Fukuyama, K; Kubota, T; Kunishima, N; Matsubara, H | 1 |
| Boucher, JL; Delaforge, M; Mansuy, D; Renaud, JP; Vadon, S | 1 |
| Marletta, MA; Pufahl, RA | 1 |
| Klatt, P; Mayer, B; Schmidt, K; Uray, G | 1 |
| Masters, BS; McMillan, K | 1 |
| Aderka, D; Dotan, I; Levo, Y; Mamet, R; Schoenfeld, N; Sztern, M | 1 |
| Hentze, MW; Pantopoulos, K | 1 |
| Chamulitrat, W; Jordan, SJ; Litton, AL; Mason, RP; Molina y Vedia, L; Wilson, JG; Wolberg, G; Wood, ER | 1 |
| Bergonia, HA; Kim, YM; Lancaster, JR; Müller, C; Pitt, BR; Watkins, WD | 1 |
| Joshi, AA; McDonald, MJ | 1 |
| Deybach, JC; Nordmann, Y; Puy, H | 1 |
| Arvela, P; Mustajoki, P; Mustajoki, S; Pelkonen, O; Rautio, A | 1 |
| Hara, T; Horiuchi, T; Nakamura, K; Sagara, Y; Sekimizu, K; Yasukochi, T | 1 |
| Bharathi, KC; Mamatha, P; Muthane, UB; Vengamma, B | 1 |
| Dover, SB; Fitzsimmons, EJ; Graham, A; McColl, KE; Moore, MR | 1 |
| Chalevelakis, G; Yalouris, AG | 1 |
| Baudry, P; Callebert, J; Deybach, JC; Nordmann, Y; Puy, H; Touitou, Y | 1 |
| Mustajoki, P; Nordmann, Y | 1 |
| Deybach, JC; Nordmann, Y | 1 |
| Erman, JE; Kraut, J; Miller, MA; Vitello, LB; Wang, J | 1 |
| Abu-Soud, HM; Brudvig, GW; Clark, P; Galli, C; MacArthur, R; Steuhr, DJ | 1 |
| Adak, S; Banerjee, RK; Mazumder, A | 1 |
| Albakri, QA; Stuehr, DJ | 1 |
| Gerber, NC; Ortiz de Montellano, PR; Rodríguez-Crespo, I | 1 |
| Bächinger, HP; Glatter, O; Klatt, P; Lehner, D; List, BM; Mayer, B; Pfeiffer, S; Schmidt, K; Werner, ER | 1 |
| Boyhan, A; Charles, I; Lowe, PN; Moncada, S; Riveros-Moreno, V; Smith, D; Stammers, DK | 1 |
| Ishimura, Y; Makino, R; Shimada, H; Toba, Y; Unno, M | 1 |
| Klatt, P; List, BM; Mayer, B; Schmidt, K; Werner, ER | 1 |
| Martasek, P; Masters, BS; Roman, LJ; Salerno, JC | 1 |
| Masters, BS; McMillan, K; Salerno, JC | 1 |
| Gao, Y; Veitch, NC; Welinder, KG | 1 |
| Berka, V; Chen, PF; Tsai, AL | 1 |
| Kottari, S; Pelkonen, O; Raunio, H; Salonpää, P | 1 |
| Battle, A; Fukuda, H; Riley, P; Washbrook, R | 1 |
| Berka, V; Chen, PF; Tsai, AL; Wu, KK | 2 |
| Gorren, AC; Mayer, B; Schmidt, K; Schrammel, A | 2 |
| Garcia, AE; Hummer, G; Oprea, TI | 1 |
| Crane, BR; Gachhui, R; Ghosh, DK; Parkinson, J; Stuehr, DJ; Wu, C | 1 |
| Kharitonov, VG; Magde, D; Martásek, P; Masters, BS; Roman, LJ; Scheele, JS; Sharma, VS | 1 |
| Boyhan, A; Charles, IG; Lowe, PN; Saqi, M; Smith, D | 1 |
| Abu-Soud, HM; Gachhui, R; Raushel, FM; Stuehr, DJ | 1 |
| Arvai, AS; Crane, BR; Gachhui, R; Getzoff, ED; Ghosh, DK; Stuehr, DJ; Tainer, JA; Wu, C | 1 |
| Fan, B; Rousseau, DL; Stuehr, DJ; Wang, J | 1 |
| Wickelgren, I | 1 |
| Abu-Soud, HM; Erzurum, S; Huang, L; Presta, A; Sennequier, N; Siddhanta, U; Stuehr, DJ; Wu, C | 1 |
| Indiani, C; Neri, F; Smulevich, G; Welinder, KG | 1 |
| Mustajoki, P; Tenhunen, R | 1 |
| Alderton, WK; Boyhan, A; Lowe, PN | 1 |
| Blackledge, M; Dolla, A; Guerlesquin, F; Marion, D; Sebban-Kreuzer, C | 1 |
| Hasegawa, J; Igarashi, Y; Kobayashi, Y; Kodama, T; Kyogoku, Y; Sambongi, Y; Yamazaki, K; Yamazaki, T; Yoshida, T; Yu, Y | 1 |
| Fan, B; Presta, A; Rousseau, DL; Siddhanta, U; Stuehr, DJ; Wolan, D | 1 |
| Daff, S; Nakano, K; Sagami, I; Shimizu, T | 1 |
| Deybach, JC; Doss, MO; Frank, M; Gross, U; Jacob, K; Nordmann, Y; Sassa, S | 1 |
| Ferrini, PR; Santini, V | 1 |
| Fibach, E; Friedberg, A; Goldfarb, A; Rachmilewitz, E; Rund, D | 1 |
| Hurshman, AR; Marletta, MA; Rusche, KM | 1 |
| Feis, A; Nissum, M; Smulevich, G | 1 |
| Gross, SS; Ikeda-Saito, M; Liu, Q; Martásek, P; Masters, BS; Migita, CT; Miller, RT; Raman, CS; Roman, LJ; Salerno, JC | 1 |
| Andrew, PJ; Brunner, K; Hemmens, B; Kungl, AJ; Mayer, B; Tortschanoff, A | 1 |
| Behr, J; Grzybek, S; Hellwig, P; Ludwig, B; Mäntele, W; Michel, H | 1 |
| Dolphin, E; Fischmann, TO; Fossetta, JD; Hruza, A; Lundell, DJ; Lunn, CA; Narula, SK; Niu, XD; Prongay, AJ; Reichert, P; Weber, PC | 1 |
| Boyington, JC; Kulansky, R; Malech, HL; Rafferty, SP; Sun, PD | 1 |
| Atkinson, RN; Ichimori, K; King, SB; Stuehr, DJ | 1 |
| Lu, Y; Wang, X | 1 |
| Buse, G; Hellwig, P; Mäntele, W; Soulimane, T | 1 |
| Berka, V; Lambry, JC; Liebl, U; Martin, JL; Négrerie, M; Tsai, AL; Vos, MH | 1 |
| Karpova, IV; Pivnik, AV; Pustovoĭt, IaS | 1 |
| Ichikawa, Y; Kawazoe, T; Kosaka, H; Mizoguchi, K; Ohnishi, T; Yoneyama, H | 1 |
| Daimon, M; Hirata, A; Kato, T; Kitagawa, M; Manaka, H; Morita, Y; Sasaki, H; Susa, S | 1 |
| Barker, PD; Fearnley, IM; Rice, JK | 1 |
| Fendler, K; Hellwig, P; Kannt, A; Ludwig, B; Mäntele, W; Michel, H; Pfitzner, U; Ruitenberg, M | 1 |
| Laakkonen, L; Puustinen, A; Riistama, S; Verkhovsky, MI; Wikström, M | 1 |
| Edmondson, DE; Hurshman, AR; Huynh, BH; Krebs, C; Marletta, MA | 1 |
| Behr, J; Hellwig, P; Mäntele, W; Michel, H | 1 |
| Arnesano, F; Banci, L; Barker, PD; Bertini, I; Ciofi-Baffoni, S; Johnson, CM; Woodyear, TL | 1 |
| Andrew, PJ; Mayer, B | 1 |
| Boggs, S; Huang, L; Stuehr, DJ | 1 |
| Das, TK; Ferguson-Miller, S; Gennis, RB; Lee, HM; Mills, D; Rousseau, DL | 1 |
| Gorren, AC; Koesling, D; Mayer, B; Riethmüller, C; Schmidt, K; Schrammel, A; Werner, ER | 1 |
| Arvai, AS; Crane, BR; Getzoff, ED; Ghosh, S; Stuehr, DJ; Tainer, JA | 1 |
| Feis, A; Howes, BD; Indiani, C; Marzocchi, MP; Smulevich, G | 1 |
| Balla, G; Balla, J; Jacob, HS; Jeney, V; Kakuk, G; Vercellotti, GM | 1 |
| Daff, S; Sagami, I; Sato, Y; Shimizu, T | 1 |
| Berka, V; Tsai, AL | 1 |
| Adak, S; Stuehr, DJ; Wang, Q | 1 |
| Hemann, C; Hille, R; Meade, AL; Stuehr, DJ; Wang, Q; Wang, ZQ; Wei, CC | 1 |
| Doss, MO; Gross, U; Kühnel, A | 1 |
| Kudo, T; Park, SY; Shiro, Y; Shoun, H; Takaya, N | 1 |
| Di Giacomo, C; Guerrera, F; Salerno, L; Siracusa, MA; Sorrenti, V; Vanella, A | 1 |
| Daimon, M; Igarashi, M; Kameda, W; Kato, T; Susa, S | 1 |
| Backgren, C; Jasaitis, A; Morgan, JE; Puustinen, A; Verkhovsky, MI; Wikström, M | 1 |
| Ghosh, S; Panda, K; Stuehr, DJ | 1 |
| Hoffmann, F; Lindberg, RL; Meyer, UA; Schuurmans, MM | 1 |
| Doss, M; Doss, MO; Gross, U; Schurek, JO | 1 |
| Elder, GH; Hift, RJ | 1 |
| Cosper, NJ; Hori, H; Iwasaki, T; Nishino, T; Scott, RA | 1 |
| Alderton, WK; Gutierrez, AF; Lian , L; Scrutton, NS; Stevenson, TH | 1 |
| Ghosh, S; Hemann, C; Hille, R; Meade, AL; Stuehr, DJ; Wang, ZQ; Wei, CC | 1 |
| Kosaka, H; Yamamoto, A; Yoneyama, H | 1 |
| Berka, V; Lambry, JC; Martin, JL; Négrerie, M; Slama-Schwok, A; Tsai, AL; Vos, MH | 1 |
| Sagami, I; Sato, Y; Shimizu, T | 2 |
| Adak, S; Aulak, KS; Bilwes, AM; Crane, BR; Getzoff, ED; Hosfield, D; McDonald, JF; Panda, K; Stuehr, DJ; Tainer, JA | 1 |
| Porasuphatana, S; Pou, S; Rosen, GM; Tsai, P | 1 |
| Gorren, AC; Mayer, B; Schmidt, K | 1 |
| Bender, AT; Demady, DR; Hollenberg, PF; Jianmongkol, S; Kamada, Y; Kent, UM; Lowe, ER; Osawa, Y; Vuletich, JL | 1 |
| Badminton, MN; Elder, GH | 1 |
| Davydov, R; Dawson, JH; Hoffman, BM; Larukhin, M; Ledbetter-Rogers, A; Martásek, P; Masters, BS; Sono, M | 1 |
| Deybach, JC; Doss, M; Doss, MO; Gross, U; Lamoril, J; Meissauer, U; Nordmann, Y; Puy, H | 1 |
| Andersson, C; Bäckström, T; Nilsson, A | 1 |
| Arndt, J; Chan, MK; Hao, B; Isaza, C; Soltis, M | 1 |
| Marks, N; Wolff, DJ | 1 |
| Ciaccio, C; Coletta, M; De Sanctis, G; Feis, A; Neri, F; Santoni, E; Smulevich, G; Welinder, KG | 1 |
| Andreoletti, P; Gagnon, J; Jaquinod, M; Jouve, HM; Sainz, G | 1 |
| Arvai, AS; Getzoff, ED; Hemann, C; Hille, R; Stuehr, DJ; Wang, ZQ; Wei, CC | 1 |
| Porasuphatana, S; Rosen, GM; Tsai, P | 1 |
| Boucher, JL; Desbois, A; Frapart, Y; Gorren, AC; Lefèvre-Groboillot, D; Mansuy, D; Mayer, B; Stuehr, DJ; Zimmermann, JL | 1 |
| Carpena, X; Chelikani, P; Fita, I; Loewen, PC | 1 |
| Ghosh, S; Mukherjee, S; Regulski, M; Sahoo, R; Sengupta, R; Stuehr, DJ; Tully, T | 1 |
| Karpova, IV; Luchinina, IuA; Luk'ianenko, AV; Pivnik, AV; Pustovoĭt, IaS; Surin, VL | 1 |
| Dalosto, SD; Kaposi, AD; Prabhu, NV; Sharp, KA; Stavrov, SS; Vanderkooi, JM; Wright, WW | 1 |
| Edmondson, DE; Hurshman, AR; Krebs, C; Marletta, MA | 1 |
| Hasui, Y; Ikeda, M; Tanabe, H | 1 |
| Rothery, RA; Weiner, JH; Zhao, Z | 1 |
| Koshikawa, K; Matsuoka, A; Mita, H; Shikama, K; Terui, N; Yamamoto, Y | 1 |
| Aulakh, P; Cross, KJ; Dashper, SG; Lissel, P; Moore, C; Reynolds, EC; Slakeski, N | 1 |
| Andersson, KK; Gorren, AC; Lange, R; Marchal, S; Mayer, B; Sørlie, M | 1 |
| Bunce, RA; Caignan, GA; Deshmukh, R; Rivera, M; Wilks, A; Zeng, Y | 1 |
| Babcock, GT; Durham, B; Ferguson-Miller, S; Geren, L; Hiser, C; Hoganson, CW; Millett, F; Mills, DA; Qian, J; Schmidt, B; Wang, K | 1 |
| Berka, V; Palmer, G; Tsai, AL; Wu, G; Yeh, HC | 1 |
| Fushinobu, S; Shoun, H; Su, F; Takaya, N | 1 |
| Brown, KA; Moody, PC; Raven, EL; Sharp, KH | 1 |
| Griffin, KJ; Johnson, EF; Schoch, GA; Stout, CD; Wester, MR; Yano, JK | 1 |
| Chartier, FJ; Couture, M | 3 |
| Beer, R; Engelhardt, K; Franz, G; Kampfl, A; Pfausler, B; Schmutzhard, E; Spiegel, M; Trinka, E; Unterberger, I | 1 |
| Gennis, RB; Hellwig, P; Osborne, JP; Zhang, J | 1 |
| Berka, V; Gao, D; Kiran, F; Tsai, AL; Yeh, HC | 1 |
| Ishikawa, K; Itabe, H; Kawamura, K; Kimura, S; Kodama, T; Kohro, T; Maruyama, Y; Matsumoto, H; Wada, Y | 1 |
| Daff, S; Ost, TW | 1 |
| Ferrand, M; Franc, JL; Le Fourn, V | 1 |
| Finazzi, G; Kallas, T; Middleton-Zarka, KA; Nelson, ME; Wang, QJ; Whitmarsh, J | 1 |
| Durra, D; Garcin, ED; Getzoff, ED; Hemann, C; Hille, R; Stuehr, DJ; Wang, ZQ; Wei, CC | 1 |
| Hift, RJ; Meissner, PN | 1 |
| Balland, V; Bouzhir-Sima, L; Kiger, L; Liebl, U; Marden, MC; Mattioli, TA; Vos, MH | 1 |
| Chen, WJ; Fang, CC; Lai, TI; Lien, WC; Liu, YP; Wang, HP | 1 |
| Gao, YT; Ingledew, WJ; Jones, RJ; Rich, PR; Salerno, JC; Smith, SM | 1 |
| Panda, K; Santolini, J; Stuehr, DJ; Wang, Q; Wang, ZQ; Wei, CC | 1 |
| Allen, JW; Ferguson, SJ; Leach, N | 1 |
| Bailey, S; Kappler, U | 1 |
| Brand, HS; Kooijman, MM | 1 |
| Akagi, R; Maeshima, K; Morita, K; Omori, E; Shimizu, H; Takahashi, T; Tani, T; Uehara, K; Yokoyama, M | 1 |
| Kadotani, T; Stevenson, DK; Vreman, HJ; Wong, RJ | 1 |
| Jellen, EE; Ryzhov, V | 1 |
| Laakkonen, L; Molin, M; Puustinen, A; Ribacka, C; Verkhovsky, M; Wikström, M | 1 |
| Durham, B; Ferguson-Miller, S; Geren, L; Hiser, C; Millett, F; Mills, DA; Schmidt, B | 1 |
| Cukier, RI; Ferguson-Miller, S; Mills, DA; Seibold, SA | 1 |
| Garcin, ED; Getzoff, ED; Konas, DW; Panda, K; Sharma, M; Stuehr, DJ; Tiso, M | 1 |
| Carpena, X; Deemagarn, T; Fita, I; Ivancich, A; Loewen, PC; Singh, R; Switala, J; Wiseman, B | 1 |
| Jenkins, GJ; Jianmongkol, S; Lau, M; Lee, AJ; Noon, KR; Osawa, Y | 1 |
| Boucher, JL; Lefèvre-Groboillot, D; Mansuy, D; Stuehr, DJ | 1 |
| Evans, JP; La Mar, GN; Ogura, H; Ortiz de Montellano, PR; Wang, J | 1 |
| Deng, H; Hayden, EY; Li, D; Panda, K; Rousseau, DL; Stuehr, DJ; Yeh, SR | 1 |
| Litzinger, EA; Martásek, P; Roman, LJ; Silverman, RB | 1 |
| Blais, SP; Chartier, FJ; Couture, M | 1 |
| Fujii, H; Nakamura, H; Shiro, Y; Tanaka, A | 1 |
| Crane, BR; Pant, K | 1 |
| Balland, V; Bouzhir-Sima, L; Hola, K; Jasaitis, A; Lambry, JC; Liebl, U; Vos, MH | 1 |
| Frank, J; Merk, HF; Poblete-Gutiérrez, P; Wiederholt, T | 1 |
| Badminton, MN; Deybach, JC | 1 |
| Bianketti, J; Gregor, A; Lipniacka, A; Szlendak, U | 1 |
| Hillier, IH; Joule, JA; Morao, I; Periyasamy, G | 1 |
| Akagi, R; Maeshima, K; Morimatsu, H; Morita, K; Sasaki, T; Shimizu, H; Takahashi, T; Takeuchi, M; Toda, Y; Yokoyama, M | 1 |
| Lockney, D; Miksovská, J | 1 |
| Schiødt, CB; Veitch, NC; Welinder, KG | 1 |
| Abitbol, M; Deybach, JC; Guénet, JL; Montagutelli, X; Puy, H; Sabaté, JM | 1 |
| Iwaki, M; Rich, PR | 1 |
| Hira, S; Ichimura, S; Ishimori, K; Kitagawa, T; Morishima, I; Taniguchi, S; Tosha, T; Uchida, T | 1 |
| Eichelbaum, M; Hustert, E; Klein, K; Pleiss, J; Raimundo, S; Saussele, T; Tatzel, S; Zanger, UM | 1 |
| Astern, JM; Cherkasov, A; Goedken, M; Huang, M; Kameoka, Y; Leidal, KG; McCormick, S; Nauseef, WM; Suzuki, K | 1 |
| Bhattacharjee, A; Dutta, T; Ghosh, S; Ray, SS; Regulski, M; Stuehr, DJ; Tejero, J; Tully, T; Wang, ZQ | 1 |
| Feder, ZM; Ignashina, EV; Karpova, IV; Kravchenko, SK; Kremenetskaia, AM; Kurtser, MA; Mironova, TS; Murashko, LE; Petrova, VI; Pustovoĭt, IaS; Pustovoĭt, LA; Shmakov, RG; Shtabnitskiĭ, AM; Sokolova, MIu | 1 |
| Borie, MJ; Chauvet, MA; Corcia, P; Diot, E; Maillot, F; Zannad, N | 1 |
| Hu, RG; Varshavsky, A; Wang, H; Xia, Z | 1 |
| Cho, KB; Gauld, JW; Robinet, JJ | 1 |
| Bauer, I; Heiser, J; Kubulus, D; Mathes, A; Pavlidis, D; Pradarutti, S; Raddatz, A; Rensing, H; Wolf, B | 1 |
| El-Mashtoly, SF; Kitagawa, T; Nakashima, S; Shimizu, T; Tanaka, A | 1 |
| Cardounel, AJ; Chen, CA; Druhan, LJ; Forbes, SP; Pope, AJ; Zweier, JL | 1 |
| Araki, Y; Igarashi, J; Ishitsuka, Y; Ito, O; Shimizu, T; Tanaka, A | 1 |
| de Visser, SP; Tan, LS | 1 |
| Biswas, A; Haque, MM; Hemann, C; Misra, S; Page, RC; Stuehr, DJ; Tejero, J; Wang, ZQ; Zweier, JL | 1 |
| Shimizu, T; Tanaka, A | 1 |
| Cape, JL; Crouch, GJ; Jones, JP; Peng, CC; Rushmore, T | 1 |
| Marletta, MA; Martin, NI; Winter, MB; Woodward, JJ | 1 |
| Fan, B; Rousseau, DL; Stuehr, DJ | 1 |
| Andersson, DE; Floderus, Y; Harper, P; Sardh, E | 1 |
| Jadhav, A; Ndisang, JF | 4 |
| Egawa, T; Gennis, RB; Lee, HJ; Rousseau, DL; Yeh, SR | 1 |
| Cappellini, MD; Rocchi, E; Ventura, P | 1 |
| Brzezinski, P; Gennis, RB; Lee, HJ; Ojemyr, L; Vakkasoglu, A | 1 |
| Brosche, C; Doss, MO; Koszka, C; Stauch, T; Stölzel, U; Teubner, A | 1 |
| Grigoryants, VM; Lee, B; Myers, WK; Scholes, CP; Shapleigh, JP; Usov, OM | 1 |
| Crane, BR; Davydov, R; Hoffman, BM; Lees, NS; Sudhamsu, J | 1 |
| Egawa, T; Gennis, RB; Hosler, JP; Lin, MT; Rousseau, DL; Yeh, SR | 1 |
| Balland, V; Boucher, JL; Giroud, C; Mattioli, TA; Moreau, M; Santolini, J; Stuehr, DJ; Xu-Li, Y | 1 |
| Fylymonenko, VP; Kaliman, PA; Nikitchenko, IV | 1 |
| Akopova-Larbi, R; Ben Youssef, TI; Gargouri, A; Gouider, R; Gouider-Khouja, N; Kraoua, I | 1 |
| Marsden, JT; Rees, DC | 1 |
| Astashkin, AV; Elmore, BO; Fan, W; Feng, C; Guillemette, JG | 1 |
| Andreas, M; Bilban, M; Clive, B; Doberer, D; Haschemi, A; Heinzl, H; Jeitler, M; Wagner, O; Wolzt, M; Zapf, TC | 1 |
| Bernhardt, PV; Hanson, GR; Kappler, U; Rapson, TD | 1 |
| Beesley, MF; Choudhary, AK; Clay, S; Conway, BC; Ferenbach, DA; Hughes, J; Kluth, DC; Marson, LP; McKay, J; Nkejabega, NC; Vernon, MA | 1 |
| Guallar, V; Lucas, MF; Rousseau, DL | 1 |
| Hasegawa, T; Kuwada, T; Sakae, T; Sato, I; Shishikura, F; Takagi, T | 1 |
| Ma, E; Mar, V; Nicoll, A; Ross, G; Varigos, G | 1 |
| Battistuzzi, G; Bellei, M; Furtmüller, PG; Gruber, C; Obinger, C; Soudi, M; Stampler, J | 1 |
| Liskova, J; Melkova, Z; Shankaran, P; Vlkova, L | 1 |
| Boucher, JL; Mansuy, D; Salard-Arnaud, I; Stuehr, D | 1 |
| Donald, LJ; Jha, V; Loewen, PC | 1 |
| Bild, V; Bild, W; Ciobica, A; Padurariu, M | 1 |
| Kotsiuruba, AV; Moĭbenko, OO; Neshcheret, OP; Rovenets', RA; Strutyns'kyĭ, RB | 1 |
| Badminton, MN; Barth, JH; Cox, TM; Rees, DC; Sarkany, R; Stein, PE; Stewart, MF | 1 |
| Andreas, M; Bilban, M; Doberer, D; Heinze, G; Moser, E; Schewzow, K; Schmid, AI; Weisshaar, S; Wolzt, M | 1 |
| Hisabori, T; Sugano, Y; Tsuge, H; Yoshida, T | 1 |
| Correia, JD; Fernandes, PA; Moreira, IS; Oliveira, BL; Ramos, MJ; Santos, I | 1 |
| Hase, T; Hori, H; Nakanishi, N; Park, SY; Rahman, MM; Sakamoto, Y; Tsubaki, M | 1 |
| Stuehr, D; Tejero, J | 1 |
| Ghosh, A; Haque, MM; Mukherjee, N; Nagpal, L; Panda, K; Ranu, BC; Saha, A; Stuehr, DJ | 1 |
| Ahuja, S; Bridges, A; Huang, R; Im, SC; Jahr, N; Le Clair, SV; Nanga, RP; Popovych, N; Ramamoorthy, A; Soong, R; Vivekanandan, S; Waskell, L; Xu, J; Yamamoto, K | 1 |
| Bayachou, M; Fadlalla, M; Haque, MM; Stuehr, DJ; Tejero, J; Wang, ZQ | 1 |
| Koszelak-Rosenblum, M; Malkowski, MG; Zhu, G | 1 |
| Greetham, GM; Hardman, SJ; Hay, S; Heyes, DJ; Hough, MA; Russell, HJ; Scrutton, NS; Towrie, M | 1 |
| Czopek, A; Edmunds, MC; Kluth, DC; Wigmore, SJ | 1 |
| Borthwick, G; Cairns, C; Choudhary, AK; Conway, BR; Hughes, J; Kluth, D; Morton, NM; Rennie, J | 1 |
| Chibbar, R; Lane, N; Ndisang, JF | 1 |
| Albertyn, CH; Bryer, A; Corrigall, A; Heckmann, JM; Meissner, P; Sonderup, M | 1 |
| Li, J; Lu, N; Peng, YY; Tian, R | 1 |
| Hnízda, A; Janošík, M; Kopecká, J; Kožich, V; Krijt, J; Melenovská, P; Raková, K; Wilcken, B | 1 |
| Chibbar, R; Ndisang, JF | 1 |
| Bolisetty, K; Hannibal, L; Haque, MM; Misra, S; Page, RC; Stuehr, DJ; Yu, Z | 1 |
| Bergman Laurila, J; Grafström, R; Hammerling, U; Ilbäck, NG | 1 |
| Hergüner, Ö; Mungan, NÖ; Nazoglu, S; Öktem, M; Turgut, M; Yildizdas, D; Yilmaz, BS | 1 |
| Astashkin, AV; Chen, L; Elmore, BO; Feng, C; Kunwar, D; Li, H; Miao, Y; Poulos, TL; Roman, LJ | 1 |
| Hino, T; Kanadani, M; Nagano, S; Ozaki, S; Sato, T | 1 |
| Chu, L; de Perrot, M; Granton, E; Granton, J; Hsin, M; Keshavjee, S; Lin, K; Peng, J; Waddell, T; Wu, L; Yin, L; Yu, A; Zhao, YD | 1 |
| Bilos, A; Dekker, D; Dorresteijn, MJ; Pennings, SW; Peters, WH; Smits, P; Wagener, FA | 1 |
| Dosi, R; Joshi, H; Patell, R; Shah, P; Tripathi, R | 1 |
| Bellamy, CO; Czopek, A; Kluth, DC; Marson, LP; McNally, SJ; Thomas, RA | 1 |
| Battaile, KP; Im, W; Kumar, R; Lovell, S; Matsumura, H; Moënne-Loccoz, P; Qi, Y; Rivera, M; Yao, H | 1 |
| Jain, V; Sharma, A; Yogavel, M | 1 |
| Gangoda, M; Haque, MM; Ramasamy, S; Stuehr, DJ | 1 |
| Cui, Y; Gu, L; Liu, S; Liu, X; Ma, Y; Wang, J; Xu, S; Yuan, Z | 1 |
| Deguchi, K; Ikeda, K; Kamada, M; Kokudo, Y; Kume, K; Masaki, T; Takata, T; Touge, T | 1 |
| Nagatoishi, S; Nakamura, N; Naoe, Y; Rahman, MM; Shiro, Y; Sugimoto, H; Tosha, T; Tsumoto, K | 1 |
| Barman-Aksözen, J; Huber, LC; Minder, E; Senn, JD | 1 |
| Bisceglie, L; Braren, R; Gehrig, P; Hopp, AK; Hottiger, MO; Koch-Nolte, F; Leutert, M; Li, H; Menzel, S; Nowak, K; Rissiek, B; Zolkiewska, A | 1 |
| Andreas, M; Aref, T; Bilban, M; Heidtmann, J; Kainz, FM; Kocher, A; Laufer, G; Messner, B; Oeser, C; Shabanian, S; Wolzt, M | 1 |
| Du, KJ; Gao, SQ; Liao, F; Lin, YW; Liu, C; Tan, X; Wei, CW; Yuan, H | 1 |
| Dojun, N; Ishimori, K; Nakamura, Y; Ota, K; Sekine, Y; Uchida, T; Umetsu, S | 1 |
| Beykirch, MK; Bronisch, O; Haverkamp, T; Petrides, PE; Stauch, T | 1 |
| Axford, D; Chaplin, AK; Davy, B; Dworkowski, FSN; Ebrahim, A; Hough, MA; Lučić, M; Owada, S; Owen, RL; Sugimoto, H; Svistunenko, DA; Tews, I; Tosha, T; Wilson, MT; Worrall, JAR | 1 |
| Esackimuthu, P; Saraswathi, NT | 1 |
| Djinović-Carugo, K; Furtmüller, PG; Hofbauer, S; Mlynek, G; Obinger, C; Pfanzagl, V; Schmidt, D; Serra, I; Van Doorslaer, S | 1 |
| Aarsand, AK; Aguilera, P; Brunet, M; Deulofeu, R; García-Villoria, J; Gómez-Gómez, À; Pozo, OJ; Sandberg, S; To-Figueras, J; Wijngaard, R | 1 |
| Beykirch, MK; Klein, M; Loehr, C; Molitor, B; Obermeier, Z; Petrides, PE; Schuhmann, E; Torkler, H | 1 |
| Bradberry, SM; Elamin, MEMO; McNally, D; Patel, NC; Stein, P; Wroe, N | 1 |
| Abu-Soud, HM; Awonuga, A; Bai, D; Camp, OG; Goud, PT | 1 |
| Horitani, M; Ito, YT; Kasu, Y; Kobayashi, K; Kozawa, T | 1 |
18 review(s) available for arginine and heme
| Article | Year |
|---|---|
Heme-dependent activation of guanylate cyclase by nitric oxide: a novel signal transduction mechanism.
Topics: Animals; Arginine; Enzyme Activation; Guanylate Cyclase; Heme; Humans; Nitric Oxide; Signal Transduction | 1991 |
Hematin: effects on hemostasis.
Topics: Arginine; Blood Coagulation; Heme; Hemin; Hemostasis; Humans; Molecular Structure; Sorbitol | 1990 |
Turnover rates of various muscle proteins.
Topics: Actins; Alanine; Amino Acids; Amino Acyl-tRNA Synthetases; Animals; Arginine; Carbon Radioisotopes; Carbonates; Female; Glutamates; Heme; Isotope Labeling; Levulinic Acids; Liver; Lysosomes; Male; Methylhistidines; Muscle Proteins; Myosins; Nitrogen; Rats; RNA, Messenger; Swine | 1974 |
Approaches toward selective inhibition of nitric oxide synthase.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Binding Sites; Calcium; Calmodulin; Drug Design; Heme; Isoenzymes; Ligands; Nitric Oxide; Nitric Oxide Synthase | 1994 |
[Hepatic porphyrias and drugs].
Topics: Acute Disease; Alanine; Arginine; Carbohydrates; Heme; Humans; Ligases; Porphyrias, Hepatic | 1994 |
Differentiation therapy of myelodysplastic syndromes: fact or fiction?
Topics: Acetamides; Amifostine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Arginine; Azacitidine; Butyrates; Cholecalciferol; Cytarabine; Harringtonines; Hematopoietic Cell Growth Factors; Heme; Homoharringtonine; Humans; Interferons; Myelodysplastic Syndromes; Retinoids | 1998 |
Catalysis by nitric oxide synthase.
Topics: Antioxidants; Arginine; Biopterins; Catalysis; Citrulline; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Heme; Hydrogen Peroxide; Isoenzymes; Nitric Oxide; Nitric Oxide Synthase | 1998 |
Enzymatic function of nitric oxide synthases.
Topics: Animals; Antioxidants; Arginine; Biopterins; Calcium; Calmodulin; Dimerization; Endothelium, Vascular; Enzyme Activation; Heme; Humans; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III | 1999 |
Treatment of acute porphyria.
Topics: Adolescent; Adult; Analgesics, Opioid; Arginine; Clinical Trials as Topic; Dietary Carbohydrates; Female; Heme; Humans; Male; Porphobilinogen; Porphyria, Acute Intermittent; Pregnancy; Pregnancy Complications; Treatment Outcome | 2001 |
Management of acute and cutaneous porphyrias.
Topics: Arginine; beta Carotene; Chloroquine; Estrogens; Ethanol; Heme; Humans; Phlebotomy; Porphyria Cutanea Tarda; Porphyria, Acute Intermittent; Porphyrias; Sunlight | 2002 |
The generation of free radicals by nitric oxide synthase.
Topics: Animals; Arginine; Free Radicals; Heme; Humans; Hydrogen Peroxide; Iron; Nitric Oxide Synthase; Superoxides | 2003 |
[Structure-function relationships of NO synthase: electron transfer reaction].
Topics: Animals; Arginine; Binding Sites; Biopterins; Calmodulin; Crystallization; Electron Transport; Heme; Humans; Iron; Nitric Oxide; Nitric Oxide Synthase; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Structure-Activity Relationship; Sulfhydryl Compounds | 2003 |
[Porphyria].
Topics: 5-Aminolevulinate Synthetase; Analgesics, Opioid; Antipsychotic Agents; Arginine; Benzodiazepines; Ferrochelatase; Haloperidol; Heme; Humans; Hydroxymethylbilane Synthase; Olanzapine; Pirenzepine; Plasma Exchange; Porphyria, Acute Intermittent; Prognosis | 2003 |
Oral aspects of porphyria.
Topics: Algorithms; Anesthesia, Dental; Arginine; Blister; Carbohydrates; Contraindications; Heme; Humans; Mouth Diseases; Photophobia; Porphobilinogen Synthase; Porphyria, Erythropoietic; Porphyrias, Hepatic; Tooth Discoloration | 2005 |
The interdependence of the reactive species of oxygen, nitrogen, and carbon.
Topics: Arginine; Carbon; Carbon Monoxide; Carbon-Sulfur Lyases; Cysteine; Heme; Heme Oxygenase (Decyclizing); Humans; Hydrogen Sulfide; Nitric Oxide Synthase; Oxidation-Reduction; Oxidative Stress; Reactive Nitrogen Species; Reactive Oxygen Species | 2013 |
Tetrahydrobiopterin in nitric oxide synthase.
Topics: Amino Acid Oxidoreductases; Arginine; Biopterins; Catalysis; Heme; Nitric Oxide; Nitric Oxide Synthase | 2013 |
Consumption of Red/Processed Meat and Colorectal Carcinoma: Possible Mechanisms Underlying the Significant Association.
Topics: Adenocarcinoma; Adenoma; Animals; Arginine; Bone Morphogenetic Proteins; Colorectal Neoplasms; Epigenesis, Genetic; Fatty Acids, Omega-6; Feeding Behavior; Food Handling; Hedgehog Proteins; Heme; Humans; Intestines; Mutagens; Neoplastic Stem Cells; Nitroso Compounds; Receptors, Notch; Red Meat; Risk Factors; Wnt Signaling Pathway | 2016 |
[CME: Acute Intermittent Porphyria: When to Think of It? What Must be Checked? How to Treat?]
Topics: Arginine; Combined Modality Therapy; Diagnosis, Differential; Female; Genetic Predisposition to Disease; Heme; Hemin; Humans; Interdisciplinary Communication; Intersectoral Collaboration; Middle Aged; Porphobilinogen; Porphyria, Acute Intermittent; Prognosis; Recurrence; Risk Factors | 2018 |
9 trial(s) available for arginine and heme
| Article | Year |
|---|---|
Haem-arginate plus tin-protoporphyrin for acute hepatic porphyria.
Topics: Adult; Arginine; Female; Heme; Humans; Liver Diseases; Metalloporphyrins; Porphyrias; Prospective Studies; Protoporphyrins | 1991 |
Controlled trial of haem arginate in acute hepatic porphyria.
Topics: Acute Disease; Adolescent; Arginine; Clinical Trials as Topic; Double-Blind Method; Female; Heme; Heroin; Humans; Infusions, Intravenous; Injections, Intravenous; Liver Diseases; Male; Meperidine; Pain; Phlebitis; Porphyrias; Random Allocation; Recurrence; Severity of Illness Index | 1989 |
Tin protoporphyrin prolongs the biochemical remission produced by heme arginate in acute hepatic porphyria.
Topics: Acute Disease; Adult; Arginine; Drug Synergism; Drug Therapy, Combination; Female; Heme; Humans; Male; Metalloporphyrins; Porphyrias, Hepatic; Protoporphyrins | 1993 |
Plasma porphobilinogen as a sensitive biomarker to monitor the clinical and therapeutic course of acute intermittent porphyria attacks.
Topics: Acute Disease; Adult; Aminolevulinic Acid; Arginine; Biomarkers; Chromatography, Ion Exchange; Drug Monitoring; Female; Glucose; Heme; Humans; Male; Porphobilinogen; Porphyria, Acute Intermittent; Sensitivity and Specificity | 2009 |
Haem arginate infusion stimulates haem oxygenase-1 expression in healthy subjects.
Topics: Adult; Arginine; Bilirubin; Dose-Response Relationship, Drug; Enzyme Induction; Haptoglobins; Heme; Heme Oxygenase-1; Hemopexin; Homozygote; Humans; Infusions, Intravenous; Male; Polymorphism, Genetic | 2010 |
Heme arginate improves reperfusion patterns after ischemia: a randomized, placebo-controlled trial in healthy male subjects.
Topics: Adolescent; Adult; Arginine; Cross-Over Studies; Follow-Up Studies; Heme; Heme Oxygenase (Decyclizing); Humans; Infusions, Intravenous; Ischemia; Leg; Magnetic Resonance Imaging; Male; Muscle, Skeletal; Oxygen Consumption; Prospective Studies; Reference Values; Reperfusion Injury; Single-Blind Method; Treatment Outcome; Young Adult | 2012 |
Hemin Preconditioning Upregulates Heme Oxygenase-1 in Deceased Donor Renal Transplant Recipients: A Randomized, Controlled, Phase IIB Trial.
Topics: Adult; Aged; Arginine; Biomarkers; Biopsy; Drug Administration Schedule; Enzyme Induction; Female; Heme; Heme Oxygenase-1; Humans; Kidney; Kidney Transplantation; Leukocytes, Mononuclear; Macrophages; Male; Middle Aged; RNA, Messenger; Scotland; Time Factors; Transplant Recipients; Treatment Outcome; Young Adult | 2016 |
Intravenous Heme Arginate Induces HO-1 (Heme Oxygenase-1) in the Human Heart.
Topics: Adult; Aged; Aged, 80 and over; Arginine; Austria; Carboxyhemoglobin; Dose-Response Relationship, Drug; Double-Blind Method; Enzyme Induction; Feasibility Studies; Female; Heme; Heme Oxygenase-1; Humans; Infusions, Intravenous; Leukocytes, Mononuclear; Male; Middle Aged; Myocardium; RNA, Messenger | 2018 |
Acute porphyrias: a German monocentric study of the biochemical, molecular genetic, and clinical data of 62 families.
Topics: Adult; Anxiety; Arginine; Depression; Family; Female; Germany; Heme; Hospitalization; Humans; Male; Porphyria, Acute Intermittent; Prospective Studies; Quality of Life; Surveys and Questionnaires | 2019 |
326 other study(ies) available for arginine and heme
| Article | Year |
|---|---|
Chemical modification of histidine residues of rabbit hemopexin.
Topics: Acetates; Animals; Apoproteins; Arginine; Binding Sites; Heme; Hemopexin; Histidine; Kinetics; Lysine; Porphyrins; Protein Binding; Protein Conformation; Rabbits; Spectrophotometry; Spectrophotometry, Ultraviolet | 1976 |
High-resolution X-ray structures of pig metmyoglobin and two CD3 mutants: Mb(Lys45----Arg) and Mb(Lys45----Ser).
Topics: Animals; Arginine; Binding Sites; Crystallography; Fourier Analysis; Heme; Iron; Ligands; Lysine; Metmyoglobin; Mutation; Protein Conformation; Serine; Structure-Activity Relationship; Swine; X-Ray Diffraction | 1992 |
Therapeutic effect of heme arginate in myelodysplastic syndromes.
Topics: Adult; Aged; Alanine Transaminase; Arginine; Aspartate Aminotransferases; Bone Marrow; Creatinine; Erythropoietin; Female; Heme; Humans; Karyotyping; Male; Middle Aged; Myelodysplastic Syndromes | 1992 |
Treatment of primary acquired sideroblastic anaemia with haem arginate.
Topics: 5-Aminolevulinate Synthetase; Aged; Aged, 80 and over; Anemia, Sideroblastic; Arginine; Heme; Humans | 1992 |
Hydrogen bond network of cytochrome P-450cam: a network connecting the heme group with helix K.
Topics: Arginine; Cytochrome P-450 Enzyme System; Heme; Hydrogen Bonding; Lysine; Models, Molecular; Mutation; Protein Conformation | 1992 |
Structural studies by proton-NMR spectroscopy of plant horseradish peroxidase C, the wild-type recombinant protein from Escherichia coli and two protein variants, Phe41----Val and Arg38----Lys.
Topics: Arginine; Cyanides; Heme; Horseradish Peroxidase; Hydroxamic Acids; Isoenzymes; Lysine; Magnetic Resonance Spectroscopy; Phenylalanine; Protein Conformation; Recombinant Proteins; Structure-Activity Relationship; Valine | 1992 |
Change in charge of an unvaried heme contact residue does not cause a major change of conformation in cytochrome c.
Topics: Alanine; Arginine; Cytochrome c Group; Electrochemistry; Heme; Isoleucine; Leucine; Magnetic Resonance Spectroscopy; Mutagenesis; Protein Conformation; Saccharomyces cerevisiae | 1991 |
Proton nuclear Overhauser effect study of the heme active site structure of chloroperoxidase.
Topics: Arginine; Binding Sites; Chloride Peroxidase; Heme; Histidine; Isoenzymes; Magnetic Resonance Spectroscopy; Mitosporic Fungi; Molecular Structure | 1992 |
Hemin and L-arginine regulation of blood pressure in spontaneous hypertensive rats.
Topics: Animals; Arachidonic Acid; Arginine; Blood Pressure; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Dose-Response Relationship, Drug; Enzyme Induction; Heme; Heme Oxygenase (Decyclizing); Hemin; Hypertension; Kidney; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxygenases; Rats; Rats, Inbred SHR; Rats, Inbred WKY; RNA, Messenger | 1991 |
Haem arginate in acute hereditary coproporphyria.
Topics: Arginine; Child; Coproporphyrins; Heme; Humans; Liver Diseases; Male; Porphyrias | 1991 |
Elevation of hormone-binding globulins in acute intermittent porphyria.
Topics: Adolescent; Adult; Aminolevulinic Acid; Arginine; Carrier Proteins; Heme; Humans; Hydrocortisone; Liver Diseases; Porphobilinogen; Porphyrias; Prospective Studies; Sex Hormone-Binding Globulin; Testosterone; Thyroxine-Binding Proteins | 1990 |
Effect of heme arginate administration on blood pressure in spontaneously hypertensive rats.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Arginine; Blood Pressure; Blotting, Northern; Cytochrome P-450 Enzyme System; Gene Expression; Heme; Heme Oxygenase (Decyclizing); Hemin; Hypertension; Kidney; Liver; Mixed Function Oxygenases; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY; RNA, Messenger | 1990 |
CO dissociation in cytochrome c peroxidase: site-directed mutagenesis shows that distal Arg 48 influences CO dissociation rates.
Topics: Arginine; Binding Sites; Carbon Monoxide; Cytochrome-c Peroxidase; Fungal Proteins; Heme; Hydrogen-Ion Concentration; Kinetics; Mutagenesis, Site-Directed; Recombinant Proteins; Saccharomyces cerevisiae | 1990 |
Effects of haem arginate on variegate porphyria.
Topics: Adult; Arginine; Feces; Female; Heme; Humans; Infusions, Intravenous; Photosensitivity Disorders; Porphyrias; Protoporphyrins; Skin; Skin Diseases | 1990 |
Regulation of heme oxygenase gene expression by cobalt in rat liver and kidney.
Topics: Animals; Arginine; Cobalt; DNA; Enzyme Induction; Gene Expression Regulation, Enzymologic; Heme; Heme Oxygenase (Decyclizing); Kidney; Liver; Male; Nucleic Acid Hybridization; Plasmids; Protoporphyrins; Rats; Rats, Inbred Strains; RNA, Messenger; Transcription, Genetic | 1990 |
[The coincidence of acute intermittent porphyria and Crohn's disease].
Topics: Acute Disease; Adult; Arginine; Crohn Disease; Diagnosis, Differential; Drug Therapy, Combination; Glucose; Heme; Humans; Male; Porphyrias; Propranolol; Quadriplegia; Remission Induction | 1990 |
Changes of myocardial functions in acute hepatic porphyrias. Role of heme arginate administration.
Topics: Acute Disease; Adult; Arginine; Cytochrome c Group; Female; Heart; Heme; Humans; Liver Diseases; Male; Middle Aged; Porphyrias | 1989 |
Haem and porphyria attacks.
Topics: Arginine; Drug Evaluation; Heme; Humans; Porphyrias | 1989 |
Effect of haem arginate on colony formation by haematopoietic progenitors in vitro.
Topics: Arginine; Colony-Forming Units Assay; Heme; Humans; Lymphokines; Tissue Inhibitor of Metalloproteinases | 1989 |
Structural assignment of the heme potentials of cytochrome c3, using a specifically modified arginine.
Topics: Arginine; Chemical Phenomena; Chemistry; Computer Graphics; Cytochrome c Group; Desulfovibrio; Electrochemistry; Heme; Magnetic Resonance Spectroscopy; Oxidation-Reduction | 1987 |
Optical and EPR spectroscopy studies on haem arginate, a new compound used for treatment of porphyria.
Topics: Arginine; Electron Spin Resonance Spectroscopy; Heme; Humans; Mathematics; Molecular Weight; Porphyrias | 1987 |
Cytochrome c peroxidase mutant active site structures probed by resonance Raman and infrared signatures of the CO adducts.
Topics: Arginine; Binding Sites; Carbon Monoxide; Cytochrome-c Peroxidase; DNA Mutational Analysis; Heme; Histidine; Hydrogen Bonding; Peroxidases; Protein Conformation; Recombinant Proteins; Saccharomyces cerevisiae; Spectrophotometry, Infrared; Spectrum Analysis, Raman | 1988 |
Fate of haem after parenteral administration of haem arginate to rabbits.
Topics: Adrenal Glands; Animals; Arginine; Bile; Carbon Radioisotopes; Erythrocytes; Heme; Injections, Intramuscular; Injections, Intravenous; Iron Radioisotopes; Kinetics; Liver; Rabbits; Tissue Distribution | 1987 |
Effect of haem arginate therapy on porphyrin metabolism and mixed function oxygenase activity in acute hepatic porphyria.
Topics: Acute Disease; Adult; Antipyrine; Arginine; Cytochrome P-450 Enzyme System; Depression, Chemical; Female; Heme; Humans; Hydroxymethylbilane Synthase; Leukocytes; Liver; Liver Diseases; Male; Mitochondria, Liver; Mixed Function Oxygenases; Porphobilinogen Synthase; Porphyrias; Porphyrins | 1987 |
Haem arginate: a new stable haem compound.
Topics: Animals; Arginine; Blood Coagulation; Blood Pressure; Drug Stability; Heme; Heme Oxygenase (Decyclizing); Hydrogen-Ion Concentration; Lethal Dose 50; Mice; Porphyrias; Spectrophotometry, Ultraviolet | 1987 |
Haem arginate treatment for hereditary sideroblastic anaemia.
Topics: Adult; Anemia, Sideroblastic; Arginine; Erythrocyte Count; Erythrocytes; Female; Ferritins; Hematocrit; Heme; Humans; Iron; Transferrin | 1989 |
Heme therapy.
Topics: Arginine; Heme; Humans | 1989 |
[Efficacy and tolerability of a new hematin in the treatment of an acute attack of porphyria].
Topics: Acute Disease; Adolescent; Arginine; Female; Heme; Humans; Porphyrias | 1987 |
Haem arginate in acute hepatic porphyrias.
Topics: Acute Disease; Arginine; Heme; Humans; Liver Diseases; Porphyrias | 1986 |
[The effect of heme arginate (Normosang Leiras--Medica) on hemostasis].
Topics: Arginine; Heme; Hemostasis; Humans; In Vitro Techniques | 1988 |
Haem arginate improves hepatic oxidative metabolism in variegate porphyria.
Topics: Adult; Antipyrine; Arginine; Feces; Female; Heme; Humans; Liver; Oxidation-Reduction; Porphyrias; Porphyrins | 1988 |
Heme arginate: effects on hemostasis.
Topics: Adult; Arginine; Blood; Blood Coagulation; Blood Coagulation Factors; Blood Platelets; Female; Heme; Hemostasis; Humans; Male; Osmolar Concentration; Time Factors | 1988 |
Heme arginate treatment for myelodysplastic syndromes.
Topics: Adult; Aged; Aged, 80 and over; Arginine; Blood Cell Count; Female; Heme; Humans; Karyotyping; Male; Middle Aged; Myelodysplastic Syndromes | 1988 |
Barbiturate and ethanol sleeping times and pharmacokinetics of propranolol in mice after intravenous administration of haem arginate.
Topics: Animals; Arginine; Ethanol; Heme; Hexobarbital; Injections, Intravenous; Kinetics; Male; Mice; Propranolol; Sleep; Time Factors | 1987 |
Haem arginate as a treatment for myelodysplastic syndromes.
Topics: Adult; Aged; Arginine; Bone Marrow; Female; Heme; Hemoglobins; Humans; Infusions, Intravenous; Leukocyte Count; Male; Myelodysplastic Syndromes; Neutrophils; Platelet Count | 1987 |
Effects of repeated intravenous administration of haem arginate upon hepatic metabolism of foreign compounds in rats and dogs.
Topics: Animals; Arginine; Dogs; Heme; Infusions, Intravenous; Liver; Male; Pharmaceutical Preparations; Rats; Rats, Inbred Strains; Species Specificity | 1987 |
The effects of haem arginate and haematin upon the allylisopropylacetamide induced experimental porphyria in rats.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Arginine; Heme; Hemin; Liver; Male; Porphobilinogen; Porphyrias; Rats; Rats, Inbred Strains | 1987 |
[Treatment of acute intermittent porphyria. The first use of Heme-arginate in Czechoslovakia].
Topics: Acute Disease; Adult; Arginine; Heme; Humans; Male; Middle Aged; Porphyrias | 1987 |
[A new drug for porphyria].
Topics: Arginine; Heme; Humans; Porphyrias | 1986 |
Pharmacokinetics of intravenously administered haem arginate.
Topics: Adult; Arginine; Female; Haptoglobins; Heme; Hemopexin; Humans; Injections, Intravenous; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; Porphyrias | 1986 |
Metabolic regulation of heme catabolism and bilirubin production. I. Hormonal control of hepatic heme oxygenase activity.
Topics: Adrenal Glands; Animals; Arginine; Bilirubin; Cyclic AMP; Enzyme Activation; Epinephrine; Fasting; Female; Glucagon; Glucose; Heme; Hydrocortisone; Hypoglycemia; Liver; Male; Nicotinic Acids; Ovary; Oxygenases; Rats; Rats, Inbred Strains; Sex Factors; Spleen; Stimulation, Chemical; Thyroxine | 1972 |
Stereochemistry of cooperative effects in hemoglobin.
Topics: Animals; Arginine; Chemical Phenomena; Chemistry; Crystallization; Diphosphoglyceric Acids; Heme; Hemoglobins; Hemoglobins, Abnormal; Histidine; Horses; Hydrogen-Ion Concentration; Kinetics; Ligands; Macromolecular Substances; Methemoglobin; Models, Structural; Oxygen; Protein Binding; Protein Conformation; Valine; X-Ray Diffraction | 1972 |
Phylogeny of hemoglobins. chain of frog (Rana esculenta) hemoglobin.
Topics: Acylation; Alkylation; Amino Acid Sequence; Amino Acids; Animals; Anura; Arginine; Artiodactyla; Biological Evolution; Chromatography, Gel; Chymotrypsin; Electrophoresis; Electrophoresis, Paper; Heme; Hemoglobins; Peptides; Primates; Rana esculenta; Species Specificity; Trypsin; Vertebrates | 1972 |
Arginyl transfer ribonucleic acid protein transferase and endogenous acceptor proteins in cultured mammalian cells.
Topics: Acyltransferases; Amino Acids; Animals; Arginine; Carbon Isotopes; Carcinoma; Cattle; Cell Line; Cells, Cultured; Chromatography, Paper; Clone Cells; Cricetinae; Electrophoresis, Disc; Fibroblasts; Haplorhini; HeLa Cells; Heme; Hemoglobins; Humans; Kidney; Laryngeal Neoplasms; Leukemia, Experimental; Mice; Peptide Chain Termination, Translational; Proteins; RNA, Transfer | 1972 |
Control of the synthesis of a major polypeptide of chloroplast membranes in Chlamydomonas reinhardi.
Topics: Arginine; Carboxy-Lyases; Chlamydomonas; Chloramphenicol; Chlorophyll; Chlorophyta; Chloroplasts; Densitometry; Electrophoresis, Polyacrylamide Gel; Heme; Light; Maleates; Malonates; Peptide Biosynthesis; Plant Proteins; RNA, Messenger; Sodium Dodecyl Sulfate; Spectrophotometry; Time Factors; Tritium | 1973 |
Influence of globin structure on the state of the heme. I. Human deoxyhemoglobin.
Topics: Arginine; Australia; Chemical Phenomena; Chemistry; Circular Dichroism; Globins; Heme; Hemoglobins; Hemoglobins, Abnormal; Humans; Hydrogen-Ion Concentration; Inositol; Macromolecular Substances; Magnetic Resonance Spectroscopy; Magnetics; Mutation; Organophosphorus Compounds; Oxygen; Oxyhemoglobins; Protein Binding; Spectrophotometry; Spectrophotometry, Ultraviolet; Succinimides; Tryptophan; Tyrosine; X-Ray Diffraction | 1974 |
Acriflavin resistance in the hemoflagellate, Leishmania tarentolae.
Topics: Acridines; Amines; Arginine; Autoradiography; Cell Nucleus; Chloramphenicol; Chromatography, Paper; Cycloheximide; Ethidium; Heme; Histocytochemistry; Leishmania; Methods; Microbial Sensitivity Tests; Microscopy, Electron; Microscopy, Fluorescence; Phenanthridines; Time Factors; Tritium | 1972 |
Carbohydrate-free media for Crithidia.
Topics: Animals; Anopheles; Arginine; Carbohydrates; Culex; Culture Media; Eukaryota; Glutamates; Glycerol; Heme; Hydrogen-Ion Concentration; Proline; Sorbitol; Succinates; Sucrose | 1971 |
Turnover of cytochromes labeled with delta-aminolevulinic acid-3H in rat liver.
Topics: Amino Acids; Animals; Arginine; Carbon Isotopes; Cytochromes; Heme; Levulinic Acids; Liver; Male; Membranes; Microsomes, Liver; Mitochondria, Liver; Protein Biosynthesis; Rats; Time Factors; Tritium | 1969 |
States of amino acid residues in proteins. XIX. Modification of arginine residues in myoglobin.
Topics: Acrylates; Aldehydes; Animals; Arginine; Binding Sites; Chemical Phenomena; Chemistry; Chromatography, Gel; Chromatography, Ion Exchange; Cyanides; Dextrans; Electrophoresis; Heme; Histidine; Horses; Hydrogen-Ion Concentration; Iodoacetates; Lysine; Methemoglobin; Methods; Methylcellulose; Myocardium; Myoglobin; Spectrophotometry; Time Factors; Ultracentrifugation; Urea | 1969 |
Amino acid composition, heme content, and molecular weight of cytochrome c3 of Desulfovibrio desulfuricans and Desulfovibrio vulgaris.
Topics: Amino Acids; Arginine; Aspartic Acid; Cytochromes; Desulfovibrio; Glutamates; Heme; Hydrogen-Ion Concentration; Isoleucine; Molecular Weight | 1970 |
Haem a, cytochrome c and total protein turnover in mitochondria from rat heart and liver.
Topics: Amino Acids; Animals; Arginine; Carbon Isotopes; Cytochromes; Female; Heme; Leucine; Levulinic Acids; Mitochondria, Liver; Mitochondria, Muscle; Myocardium; Proteins; Rats; Tritium | 1970 |
H+ titration studies on human hemoglobin.
Topics: Arginine; Benzoates; Chemical Phenomena; Chemistry; Globins; Heme; Hemoglobins; Histidine; Humans; Hydrogen-Ion Concentration; Iodoacetates; Lysine; Mathematics; Mercury; Organometallic Compounds; Oxygen; Sulfhydryl Compounds | 1970 |
Turnover of heme and protein moieties of rat liver microsomal cytochrome b5.
Topics: Amino Acids; Animals; Arginine; Carbon Isotopes; Cycloheximide; Cytochromes; Depression, Chemical; Guanidines; Half-Life; Heme; Kinetics; Leucine; Levulinic Acids; Male; Microsomes, Liver; Protein Biosynthesis; Proteins; Rats; Tritium | 1970 |
The terminal groups of chlorocruorin.
Topics: Alanine; Amino Acid Sequence; Animals; Annelida; Arginine; Carboxypeptidases; Glutamates; Heme; Hemolymph; Histidine; Microscopy, Electron; Molecular Weight; Nitrobenzenes; Peptides; Proteins; Tyrosine | 1971 |
Purification and characterization of cytochrome 553 from the chrysophycean alga Monochrysis lutheri.
Topics: Amino Acids; Arginine; Autoanalysis; Chemical Precipitation; Chromatography, Gel; Chromatography, Ion Exchange; Cysteine; Cytochromes; Dialysis; Electron Transport; Electrophoresis, Disc; Eukaryota; Freeze Drying; Heme; Histidine; Iron; Isoelectric Focusing; Methionine; Methods; Molecular Weight; Oxidation-Reduction; Photosynthesis; Proline; Quaternary Ammonium Compounds; Spectrophotometry; Sulfates; Tryptophan; Ultracentrifugation; Ultraviolet Rays | 1971 |
Type c ferri- and ferrohemochrome formation between hemin c, amino acids, and peptides.
Topics: Amino Acids; Ammonia; Arginine; Cytochromes; Detergents; Glycine; Heme; Histidine; Hydrogen-Ion Concentration; Imidazoles; Indoles; Iron; Lysine; Methionine; Peptides; Pigments, Biological; Porphyrins; Protein Binding; Spectrophotometry; Sulfur; Tryptophan | 1968 |
New unstable haemoglobin borås: beta 88 (F4) leucine-arginine.
Topics: Amino Acid Sequence; Arginine; Electrophoresis; Heme; Hemoglobins, Abnormal; Leucine; Mutation; Peptides; Trypsin | 1969 |
The control of hemoglobin synthesis.
Topics: Animals; Arginine; Blood Proteins; Globins; Glycine; Heme; Hemoglobins; Nucleic Acids; Rabbits; Radioisotopes; Reticulocytes; Succinates | 1967 |
Characterization by electron paramagnetic resonance of the interactions of L-arginine and L-thiocitrulline with the heme cofactor region of nitric oxide synthase.
Topics: Animals; Arginine; Binding Sites; Cell Line; Citrulline; Electron Spin Resonance Spectroscopy; Heme; Kidney; Nitric Oxide Synthase; Protein Conformation; Rats; Recombinant Proteins; Thermodynamics; Thiourea; Transfection | 1995 |
Nitric oxide synthases reveal a role for calmodulin in controlling electron transfer.
Topics: Amino Acid Oxidoreductases; Arginine; Calcium; Calmodulin; Enzyme Activation; Heme; Macrophages; NADP; Neurons; Nitric Oxide Synthase; Oxidation-Reduction; Recombinant Proteins | 1993 |
Nitric oxide is a mediator of the decrease in cytochrome P450-dependent metabolism caused by immunostimulants.
Topics: Adjuvants, Immunologic; Amino Acid Oxidoreductases; Animals; Arginine; Chickens; Cytochrome P-450 Enzyme System; Heme; Lipopolysaccharides; Microsomes, Liver; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Spectrum Analysis | 1993 |
L-arginine and calmodulin regulation of the heme iron reactivity in neuronal nitric oxide synthase.
Topics: Amino Acid Oxidoreductases; Arginine; Binding Sites; Calmodulin; Carbon Monoxide; Cells, Cultured; Heme; Humans; Iron; Kinetics; Neurons; Nitric Oxide Synthase | 1994 |
Nitric oxide inhibits neuronal nitric oxide synthase by interacting with the heme prosthetic group. Role of tetrahydrobiopterin in modulating the inhibitory action of nitric oxide.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Carbon Monoxide; Cerebellum; Citrulline; Cyanides; Heme; NADP; Neurons; Nitric Oxide; Nitric Oxide Synthase; Oxidants; Oxyhemoglobins; Rats; Sulfhydryl Compounds; Superoxide Dismutase | 1994 |
L-thiocitrulline. A stereospecific, heme-binding inhibitor of nitric-oxide synthases.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Binding Sites; Citrulline; Cytochrome c Group; Heme; Kinetics; Male; Nitric Oxide Synthase; omega-N-Methylarginine; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Thiourea | 1994 |
Heme coordination of NO in NO synthase.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Brain; Cell Line; Heme; Iron; Kidney; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Rats; Recombinant Proteins; Spectrophotometry; Spectrum Analysis, Raman; Transfection | 1994 |
Characterization of the inactivation of nitric oxide synthase by NG-methyl-L-arginine: evidence for heme loss.
Topics: Amino Acid Oxidoreductases; Arginine; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Citrulline; Cytochrome P-450 Enzyme System; Enzyme Stability; Heme; Hemeproteins; Hydrogen Peroxide; Isotope Labeling; Nitric Oxide Synthase; omega-N-Methylarginine; Solubility; Spectrophotometry; Tritium | 1994 |
Electron transfer in the nitric-oxide synthases. Characterization of L-arginine analogs that block heme iron reduction.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biological Transport; Cells, Cultured; Citrulline; Cloning, Molecular; Electrons; Heme; Humans; Iron; Kinetics; NADP; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; omega-N-Methylarginine; Oxidation-Reduction; Rats; Thiourea | 1994 |
Nitric oxide complexes of inducible nitric oxide synthase: spectral characterization and effect on catalytic activity.
Topics: Amino Acid Oxidoreductases; Anaerobiosis; Animals; Arginine; Cell Line; Cytochrome P-450 Enzyme System; Enzyme Induction; Heme; Hemoglobins; Kinetics; Macrophages; Mice; Nitric Oxide; Nitric Oxide Synthase; Spectrophotometry | 1995 |
Laser photolysis behavior of ferrous horseradish peroxidase with carbon monoxide and cyanide: effects of mutations in the distal heme pocket.
Topics: Arginine; Base Sequence; Carbon Monoxide; Cyanides; Ferrous Compounds; Heme; Histidine; Horseradish Peroxidase; Kinetics; Lasers; Molecular Sequence Data; Mutagenesis, Site-Directed; Photolysis; Recombinant Proteins; Spectrum Analysis | 1995 |
New treatment for porphyria to be studied.
Topics: Arginine; Female; Heme; Humans; Infusions, Intravenous; Male; Porphyrias | 1995 |
Crystal structures of cyanide- and triiodide-bound forms of Arthromyces ramosus peroxidase at different pH values. Perturbations of active site residues and their implication in enzyme catalysis.
Topics: Amino Acid Sequence; Arginine; Binding Sites; Computer Graphics; Crystallography, X-Ray; Fourier Analysis; Heme; Histidine; Hydrogen-Ion Concentration; Iodides; Mitosporic Fungi; Models, Molecular; Periodic Acid; Peroxidases; Potassium Compounds; Potassium Cyanide | 1995 |
Particular ability of liver P450s3A to catalyze the oxidation of N omega-hydroxyarginine to citrulline and nitrogen oxides and occurrence in no synthases of a sequence very similar to the heme-binding sequence in P450s.
Topics: Amino Acid Oxidoreductases; Amino Acid Sequence; Animals; Arginine; Catalysis; Citrulline; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Heme; Isoenzymes; Male; Microsomes, Liver; Molecular Sequence Data; Nitric Oxide Synthase; Nitrogen Oxides; Oxidation-Reduction; Rats | 1993 |
Oxidation of NG-hydroxy-L-arginine by nitric oxide synthase: evidence for the involvement of the heme in catalysis.
Topics: Amino Acid Oxidoreductases; Anaerobiosis; Animals; Arginine; Carbon Monoxide; Catalysis; Cell Line; Heme; Kinetics; Macrophages; Mice; Nitric Oxide Synthase; Oxidation-Reduction; Spectrophotometry; Substrate Specificity | 1993 |
Multiple catalytic functions of brain nitric oxide synthase. Biochemical characterization, cofactor-requirement, and the role of N omega-hydroxy-L-arginine as an intermediate.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Brain; Catalysis; Coenzymes; Heme; Hydrolysis; Kinetics; NADP; Nitric Oxide Synthase; Oxidation-Reduction; Substrate Specificity; Swine | 1993 |
Optical difference spectrophotometry as a probe of rat brain nitric oxide synthase heme-substrate interaction.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Brain; Cell Line; Heme; Humans; Kidney; Kinetics; Nitric Oxide Synthase; omega-N-Methylarginine; Protein Binding; Rats; Spectrophotometry; Transfection | 1993 |
Relation between uroporphyrin excretion, acute attacks of hereditary coproporphyria and successful treatment with haem arginate.
Topics: Acute Disease; Adult; Arginine; Erythrocytes; Heme; Humans; Hydroxymethylbilane Synthase; Male; Porphyrias, Hepatic; Porphyrins; Spectrometry, Fluorescence; Uroporphyrins | 1995 |
Rapid responses to oxidative stress mediated by iron regulatory protein.
Topics: Aconitate Hydratase; Animals; Arginine; Cells, Cultured; Citrates; Citric Acid; Ethers, Cyclic; Ferritins; Fibroblasts; Heme; Hydrogen Peroxide; Iron-Regulatory Proteins; Mice; Okadaic Acid; Oxidative Stress; Phosphoprotein Phosphatases; Receptors, Transferrin; RNA-Binding Proteins; RNA, Messenger | 1995 |
Targets of nitric oxide in a mouse model of liver inflammation by Corynebacterium parvum.
Topics: Animals; Arginine; Blood; Blotting, Western; Disease Models, Animal; Electron Spin Resonance Spectroscopy; Heme; Hemoglobins; Inflammation; Liver; Liver Diseases; Male; Mice; Nitric Oxide; omega-N-Methylarginine; Propionibacterium acnes | 1995 |
Loss and degradation of enzyme-bound heme induced by cellular nitric oxide synthesis.
Topics: Arginine; Catalase; Cells, Cultured; Cytochrome P-450 Enzyme System; Cytokines; Heme; Iron; Liver; Microsomes, Liver; Nitric Oxide; omega-N-Methylarginine; Penicillamine; RNA, Messenger; S-Nitroso-N-Acetylpenicillamine; Vasodilator Agents | 1995 |
Role of alpha and beta carboxyl-terminal residues in the kinetics of human oxyhemoglobin dimer assembly.
Topics: Amino Acid Sequence; Arginine; Genetic Variation; Glutamates; Glutamic Acid; Heme; Hemoglobin A; Hemoglobins, Abnormal; Histidine; Humans; Hydrogen-Ion Concentration; Kinetics; Macromolecular Substances; Oxyhemoglobins; Point Mutation; Spectrophotometry; Tyrosine; Valine | 1994 |
Effects of heme arginate on cytochrome P450-mediated metabolism of drugs in patients with variegate porphyria and in healthy men.
Topics: Adult; Arginine; Caffeine; Coumarins; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Heme; Humans; Isoenzymes; Lidocaine; Male; Middle Aged; Porphyrias, Hepatic; Reference Values | 1994 |
Significant contribution of arginine-112 and its positive charge of Pseudomonas putida cytochrome P-450cam in the electron transport from putidaredoxin.
Topics: Arginine; Base Sequence; Camphor; Cytochrome P-450 Enzyme System; Electron Transport; Enzyme Stability; Escherichia coli; Ferredoxins; Heme; Molecular Sequence Data; Mutation; Pseudomonas putida; Spectrophotometry, Ultraviolet | 1994 |
Porphyric neuropathy: prevention of progression using haeme-arginate.
Topics: Adult; Arginine; Glucose Solution, Hypertonic; Heme; Humans; Male; Peripheral Nervous System Diseases; Porphyria, Acute Intermittent | 1993 |
Haem administration in myelodysplastic syndromes: a possible mechanism of action.
Topics: alpha-Thalassemia; Arginine; beta-Thalassemia; Globins; Heme; Humans; Myelodysplastic Syndromes; Reticulocytes | 1993 |
Decreased nocturnal plasma melatonin levels in patients with recurrent acute intermittent porphyria attacks.
Topics: Adult; Arginine; Circadian Rhythm; Female; Heme; Humans; Melatonin; Porphyria, Acute Intermittent; Recurrence; Tryptophan | 1993 |
Early administration of heme arginate for acute porphyric attacks.
Topics: Adult; Aged; Arginine; Female; Heme; Humans; Length of Stay; Male; Middle Aged; Porphyria, Acute Intermittent; Time Factors; Treatment Outcome | 1993 |
[Acute attacks of hepatic porphyria: specific treatment with heme arginate].
Topics: Acute Disease; Arginine; Female; Heme; Hospitalization; Humans; Infusions, Intravenous; Male; Porphyrias, Hepatic; Time Factors | 1993 |
Effect of arginine-48 replacement on the reaction between cytochrome c peroxidase and hydrogen peroxide.
Topics: Arginine; Crystallography; Cytochrome-c Peroxidase; Fungal Proteins; Heme; Hydrogen Peroxide; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Saccharomyces cerevisiae; Structure-Activity Relationship; X-Ray Diffraction | 1993 |
EPR spectroscopic characterization of neuronal NO synthase.
Topics: Animals; Arginine; Binding Sites; Electron Spin Resonance Spectroscopy; Electron Transport; Flavin-Adenine Dinucleotide; Free Radicals; Heme; In Vitro Techniques; Iron; Microwaves; Molecular Structure; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase | 1996 |
Probing the active site residues in aromatic donor oxidation in horseradish peroxidase: involvement of an arginine and a tyrosine residue in aromatic donor binding.
Topics: Arginine; Binding Sites; Carbon Radioisotopes; Circular Dichroism; Cyclohexanones; Diacetyl; Enzyme Inhibitors; Heme; Horseradish Peroxidase; Kinetics; Models, Structural; Phenylglyoxal; Protein Structure, Secondary; Spectrophotometry; Tetranitromethane; Thermodynamics; Tyrosine | 1996 |
Intracellular assembly of inducible NO synthase is limited by nitric oxide-mediated changes in heme insertion and availability.
Topics: Aminolevulinic Acid; Animals; Arginine; Biopterins; Cell Line; Cytokines; Enzyme Induction; Enzyme Inhibitors; Heme; Homeostasis; Interferon-gamma; Iron; Isoenzymes; Kinetics; Lipopolysaccharides; Macromolecular Substances; Macrophage Activation; Macrophages; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Recombinant Proteins; Time Factors | 1996 |
Endothelial nitric-oxide synthase. Expression in Escherichia coli, spectroscopic characterization, and role of tetrahydrobiopterin in dimer formation.
Topics: Animals; Arginine; Biopterins; Cattle; Chromatography, Affinity; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Heme; Histidine; Kinetics; Macromolecular Substances; Molecular Weight; Nitric Oxide Synthase; Protein Denaturation; Recombinant Proteins; Restriction Mapping; Sequence Tagged Sites; Spectrophotometry; Substrate Specificity | 1996 |
Characterization of heme-deficient neuronal nitric-oxide synthase reveals a role for heme in subunit dimerization and binding of the amino acid substrate and tetrahydrobiopterin.
Topics: Animals; Arginine; Binding Sites; Biopterins; Brain; Chromatography, Gel; Circular Dichroism; Citrulline; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Heme; Isoenzymes; Light; Macromolecular Substances; Neurons; Nitric Oxide Synthase; Nitroarginine; Protein Conformation; Protein Structure, Secondary; Rats; Scattering, Radiation; Thermodynamics | 1996 |
Identification of the domains of neuronal nitric oxide synthase by limited proteolysis.
Topics: Amino Acid Sequence; Animals; Arginine; Binding Sites; Biopterins; Blotting, Western; Brain; Calmodulin; Chymotrypsin; Cytochrome c Group; Electrophoresis, Polyacrylamide Gel; Flavin Mononucleotide; Heme; Humans; Molecular Sequence Data; Molecular Weight; Nitric Oxide Synthase; Nitroarginine; Peptide Fragments; Rabbits; Rats; Recombinant Proteins; Trypsin | 1996 |
Role of Arg112 of cytochrome p450cam in the electron transfer from reduced putidaredoxin. Analyses with site-directed mutants.
Topics: Arginine; Binding Sites; Camphor 5-Monooxygenase; Cytochrome P-450 Enzyme System; Electron Transport; Ferredoxins; Ferric Compounds; Heme; Kinetics; Mixed Function Oxygenases; Mutagenesis, Site-Directed; Mutation; Oxidation-Reduction; Oxygen Consumption; Potentiometry; Protein Binding | 1996 |
Overexpression of neuronal nitric oxide synthase in insect cells reveals requirement of haem for tetrahydrobiopterin binding.
Topics: Animals; Arginine; Baculoviridae; Biopterins; Brain; Citrulline; Culture Media; Flavins; Heme; Kinetics; Neurons; Nitric Oxide Synthase; Protein Processing, Post-Translational; Rats; Recombinant Proteins; Spodoptera; Tritium | 1996 |
Electron paramagnetic resonance spectroscopy of the heme domain of inducible nitric oxide synthase: binding of ligands at the arginine site induces changes in the heme ligation geometry.
Topics: Animals; Arginine; Base Sequence; Binding Sites; Cloning, Molecular; DNA Primers; Electron Spin Resonance Spectroscopy; Heme; Isoenzymes; Ligands; Mice; Molecular Sequence Data; Nitric Oxide Synthase; Polymerase Chain Reaction; Protein Conformation; Recombinant Fusion Proteins; Recombinant Proteins | 1996 |
Binding of intermediate, product, and substrate analogs to neuronal nitric oxide synthase: ferriheme is sensitive to ligand-specific effects in the L-arginine binding site.
Topics: Animals; Arginine; Binding Sites; Cell Line; Citrulline; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Heme; Kidney; Neurons; Nitric Oxide Synthase; Nitroarginine; omega-N-Methylarginine; Ornithine; Rats | 1996 |
The Asp245-->Asn mutant of Coprinus cinereus peroxidase. Characterization by 1H-NMR spectroscopy and comparison with the wild-type enzyme.
Topics: Arginine; Coprinus; Cyanides; Fluorides; Fungal Proteins; Heme; Histidine; Hydrogen Bonding; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Peroxidases; Point Mutation | 1996 |
Spatial relationship between L-arginine and heme binding sites of endothelial nitric-oxide synthase.
Topics: Arginine; Binding Sites; Binding, Competitive; Cyanides; Endothelium, Vascular; Heme; Humans; Imidazoles; Kinetics; Lysine; Nitric Oxide Synthase | 1996 |
Regulation of CYP 2 A 5 induction by porphyrinogenic agents in mouse primary hepatocytes.
Topics: Animals; Arginine; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Dactinomycin; Enzyme Induction; Griseofulvin; Heme; Liver; Male; Mice; Mice, Inbred DBA; Mixed Function Oxygenases; Nitrobenzoates; Phenobarbital; RNA, Messenger | 1997 |
Stimulation of tetrapyrrole synthesis in mammalian epithelial cells in culture by exposure to aminolaevulinic acid.
Topics: Aminolevulinic Acid; Animals; Arginine; Biological Transport; Carbon Radioisotopes; Cattle; Cell Division; Cell Line; Cycloheximide; Dactinomycin; Epithelium; gamma-Aminobutyric Acid; Glutamic Acid; Heme; Kinetics; Leucine; Mammals; Pyrroles; Radioisotope Dilution Technique; Tetrapyrroles | 1997 |
Mutation of Glu-361 in human endothelial nitric-oxide synthase selectively abolishes L-arginine binding without perturbing the behavior of heme and other redox centers.
Topics: Amino Acid Sequence; Arginine; Binding Sites; Electron Spin Resonance Spectroscopy; Endothelium, Vascular; Glutamates; Heme; Hemeproteins; Humans; Molecular Sequence Data; Molecular Weight; NADP; Nitric Oxide Synthase; Oxidation-Reduction; Structure-Activity Relationship | 1997 |
Thiols and neuronal nitric oxide synthase: complex formation, competitive inhibition, and enzyme stabilization.
Topics: Animals; Arginine; Biopterins; Calmodulin; Cysteine; Dithiothreitol; Enzyme Inhibitors; Enzyme Stability; Flavin-Adenine Dinucleotide; Heme; Mercaptoethanol; NADP; Neurons; Nitric Oxide Synthase; Protein Binding; Rats; Spectrometry, Fluorescence; Spectrophotometry; Sulfhydryl Compounds; Temperature | 1997 |
Identification of a functional water channel in cytochrome P450 enzymes.
Topics: Amino Acid Sequence; Arginine; Binding Sites; Camphor 5-Monooxygenase; Conserved Sequence; Crystallography, X-Ray; Cytochrome P-450 Enzyme System; Enzyme Stability; Heme; Mixed Function Oxygenases; Models, Molecular; Protein Conformation; Water | 1997 |
Mutagenesis of acidic residues in the oxygenase domain of inducible nitric-oxide synthase identifies a glutamate involved in arginine binding.
Topics: Alanine; Amino Acid Sequence; Animals; Antioxidants; Arginine; Biopterins; Cattle; Chromatography, Gel; Glutamic Acid; Heme; Humans; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Nitric Oxide Synthase; Oxygenases; Rats; Structure-Activity Relationship | 1997 |
Kinetics of CO ligation with nitric-oxide synthase by flash photolysis and stopped-flow spectrophotometry.
Topics: Animals; Arginine; Carbon Monoxide; Heme; Kinetics; Nitric Oxide Synthase; Photolysis; Rats; Spectrophotometry | 1997 |
Delineation of the arginine- and tetrahydrobiopterin-binding sites of neuronal nitric oxide synthase.
Topics: Amino Acid Sequence; Animals; Antioxidants; Arginine; Binding Sites; Biopterins; Calorimetry; Escherichia coli; Heme; Humans; Mice; Molecular Sequence Data; Neurons; Nitric Oxide Synthase; Peptide Mapping; Rats; Sequence Alignment; Structure-Activity Relationship | 1997 |
The ferrous-dioxy complex of neuronal nitric oxide synthase. Divergent effects of L-arginine and tetrahydrobiopterin on its stability.
Topics: Animals; Arginine; Biopterins; Catalysis; Enzyme Stability; Ferrous Compounds; Heme; Models, Chemical; Neurons; Nitric Oxide Synthase; Oxygen; Rats; Spectrophotometry, Atomic | 1997 |
The structure of nitric oxide synthase oxygenase domain and inhibitor complexes.
Topics: Amino Acid Sequence; Arginine; Binding Sites; Biopterins; Caenorhabditis elegans Proteins; Catalysis; Crystallography, X-Ray; Dimerization; Enzyme Induction; Enzyme Inhibitors; Guanidines; Heme; Homeodomain Proteins; Hydrogen Bonding; Imidazoles; Isoenzymes; Models, Molecular; Molecular Sequence Data; Nitric Oxide Synthase; Oxidation-Reduction; Oxygen; Oxygenases; Protein Conformation; Protein Folding; Protein Structure, Secondary | 1997 |
NO synthase isozymes have distinct substrate binding sites.
Topics: Animals; Arginine; Binding Sites; Brain; Carbon Monoxide; Cattle; Cysteine; Endothelium, Vascular; Heme; Isoenzymes; Mice; Nitric Oxide Synthase; Protein Conformation; Rats; Spectrum Analysis, Raman | 1997 |
Biologists catch their first detailed look at NO enzyme.
Topics: Arginine; Binding Sites; Crystallography, X-Ray; Enzyme Induction; Enzyme Inhibitors; Heme; Humans; Isoenzymes; Models, Molecular; Nitric Oxide; Nitric Oxide Synthase; Protein Conformation; Signal Transduction | 1997 |
Comparative functioning of dihydro- and tetrahydropterins in supporting electron transfer, catalysis, and subunit dimerization in inducible nitric oxide synthase.
Topics: Animals; Arginine; Biopterins; Catalysis; Dimerization; Electron Transport; Enzyme Induction; Heme; Iron; Kinetics; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Pterins; Spectrophotometry | 1998 |
Mutation of the distal arginine in Coprinus cinereus peroxidase--structural implications.
Topics: Amino Acid Sequence; Amino Acid Substitution; Arginine; Binding Sites; Coprinus; Crystallography, X-Ray; Fluorides; Heme; Histidine; Iron; Ligands; Models, Molecular; Mutagenesis, Site-Directed; Peroxidases; Protein Conformation; Recombinant Proteins; Spectrophotometry; Spectrum Analysis, Raman | 1998 |
Acute porphyria: treatment with heme.
Topics: Acute Disease; Arginine; Heme; Hemin; Humans; Porphyrias, Hepatic | 1998 |
Effects of pH on the structure and function of neuronal nitric oxide synthase.
Topics: Animals; Arginine; Biopterins; Brain; Citrulline; Dimerization; Heme; Hydrogen Peroxide; Hydrogen-Ion Concentration; NADP; Nerve Tissue Proteins; Nitric Oxide Synthase; Protein Binding; Protein Conformation; Rats; Spectrophotometry | 1998 |
Nitroarginine and tetrahydrobiopterin binding to the haem domain of neuronal nitric oxide synthase using a scintillation proximity assay.
Topics: Animals; Arginine; Binding Sites; Binding, Competitive; Biopterins; Enzyme Inhibitors; Heme; Indazoles; Isothiuronium; Kinetics; Nitric Oxide Synthase; Nitroarginine; Oxidoreductases; Oxygenases; Peptide Fragments; Protein Binding; Rats; Recombinant Fusion Proteins | 1998 |
Tyrosine 64 of cytochrome c553 is required for electron exchange with formate dehydrogenase in Desulfovibrio vulgaris Hildenborough.
Topics: Amino Acid Substitution; Arginine; Cytochrome c Group; Desulfovibrio vulgaris; Electron Transport; Formate Dehydrogenases; Heme; Hydrogen Bonding; Kinetics; Magnetic Resonance Spectroscopy; Models, Molecular; Mutagenesis, Site-Directed; Oxidation-Reduction; Protein Conformation; Static Electricity; Tyrosine | 1998 |
Solution structure of thermostable cytochrome c-552 from Hydrogenobacter thermophilus determined by 1H-NMR spectroscopy.
Topics: Amino Acid Sequence; Arginine; Bacteria, Aerobic; Bacterial Proteins; Crystallography, X-Ray; Cytochrome c Group; Heme; Hydrogen Bonding; Lysine; Models, Molecular; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Peptides; Protein Conformation; Protein Folding; Protons; Pseudomonas aeruginosa; Sequence Homology, Amino Acid; Solutions; Thermodynamics; Tyrosine | 1998 |
Domain swapping in inducible nitric-oxide synthase. Electron transfer occurs between flavin and heme groups located on adjacent subunits in the dimer.
Topics: Arginine; Binding Sites; Catalysis; Dimerization; Electron Transport; Escherichia coli; Flavins; Heme; NADP; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Point Mutation; Protein Conformation; Spectrophotometry, Atomic; Spectrum Analysis, Raman | 1998 |
Chiral recognition at the heme active site of nitric oxide synthase is markedly enhanced by L-arginine and 5,6,7,8-tetrahydrobiopterin.
Topics: Anaerobiosis; Animals; Antioxidants; Arginine; Binding Sites; Biopterins; Calmodulin; Cloning, Molecular; Heme; Kinetics; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Recombinant Proteins; Saccharomyces cerevisiae; Spectrophotometry; Stereoisomerism | 1998 |
5-Aminolevulinic acid dehydratase deficiency porphyria: a twenty-year clinical and biochemical follow-up.
Topics: Adolescent; Aminolevulinic Acid; Arginine; Biomarkers; Erythrocytes; Follow-Up Studies; Glucose; Heme; Humans; Male; Mutation; Porphobilinogen Synthase; Porphyria, Acute Intermittent; Porphyrins | 1998 |
Heme arginate therapy for beta thalassemia: in vitro versus in vivo effects.
Topics: Adult; Arginine; beta-Thalassemia; Cells, Cultured; Female; Heme; Humans; Infusions, Intravenous; Male; Treatment Outcome | 1998 |
Characterization of soybean seed coat peroxidase: resonance Raman evidence for a structure-based classification of plant peroxidases.
Topics: Arginine; Ferric Compounds; Ferrous Compounds; Glycine max; Heme; Histidine; Hydrogen Bonding; Hydrogen-Ion Concentration; Molecular Structure; Peroxidases; Seeds; Sodium Fluoride; Spectrophotometry; Spectrum Analysis, Raman; Temperature | 1998 |
Effects of Asp-369 and Arg-372 mutations on heme environment and function in human endothelial nitric-oxide synthase.
Topics: Amino Acid Sequence; Amino Acid Substitution; Arginine; Aspartic Acid; Carbon Monoxide; Catalytic Domain; DNA Primers; Heme; Humans; Imidazoles; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Spectrophotometry | 1998 |
The C331A mutant of neuronal nitric-oxide synthase is defective in arginine binding.
Topics: Animals; Arginine; Biopterins; Calmodulin; Carbon Monoxide; Catalytic Domain; Conserved Sequence; Cysteine; Electron Spin Resonance Spectroscopy; Escherichia coli; Heme; Mutation; NADP; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidation-Reduction; Rats; Recombinant Proteins; Spectrophotometry; Structure-Activity Relationship | 1998 |
Sensitivity of flavin fluorescence dynamics in neuronal nitric oxide synthase to cofactor-induced conformational changes and dimerization.
Topics: Animals; Arginine; Biopterins; Brain; Calmodulin; Dimerization; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Flavins; Fluorescence Polarization; Heme; Holoenzymes; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Protein Binding; Protein Conformation; Rats; Spectrometry, Fluorescence; Substrate Specificity; Thermodynamics | 1998 |
Electrochemical and ultraviolet/visible/infrared spectroscopic analysis of heme a and a3 redox reactions in the cytochrome c oxidase from Paracoccus denitrificans: separation of heme a and a3 contributions and assignment of vibrational modes.
Topics: Arginine; Aspartic Acid; Electrochemistry; Electron Transport Complex IV; Glutamic Acid; Heme; Molecular Conformation; Oxidation-Reduction; Paracoccus denitrificans; Porphyrins; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Tyrosine | 1999 |
Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation.
Topics: Amino Acid Sequence; Animals; Arginine; Binding Sites; Biopterins; Conserved Sequence; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Heme; Humans; Mice; Molecular Sequence Data; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Protein Structure, Secondary; Recombinant Proteins; Sequence Homology, Amino Acid; Substrate Specificity | 1999 |
Stoichiometric arginine binding in the oxygenase domain of inducible nitric oxide synthase requires a single molecule of tetrahydrobiopterin per dimer.
Topics: Animals; Arginine; Binding Sites; Biopterins; Carbon Monoxide; Chromatography, Gel; Conserved Sequence; Dimerization; Dithionite; Ferrous Compounds; Heme; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxygenases; Protein Binding; Recombinant Proteins; Spectrophotometry, Ultraviolet; Titrimetry | 1999 |
Synthesis and evaluation of new sulfur-containing L-arginine-derived inhibitors of nitric oxide synthase.
Topics: Arginine; Citrulline; Enzyme Inhibitors; Heme; Isoenzymes; NADPH Oxidases; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Structure-Activity Relationship | 1999 |
Proton NMR investigation of the heme active site structure of an engineered cytochrome c peroxidase that mimics manganese peroxidase.
Topics: Arginine; Aspartic Acid; Binding Sites; Cyanides; Cytochrome-c Peroxidase; Glutamic Acid; Glycine; Heme; Histidine; Leucine; Molecular Mimicry; Nuclear Magnetic Resonance, Biomolecular; Peroxidases; Protein Engineering; Protons; Spectrophotometry; Valine | 1999 |
Electrochemical, FTIR, and UV/VIS spectroscopic properties of the ba(3) oxidase from Thermus thermophilus.
Topics: Arginine; Aspartic Acid; Buffers; Cytochrome b Group; Deuterium Oxide; Electrochemistry; Electron Transport Complex IV; Glutamic Acid; Heme; Lysine; Oxidation-Reduction; Peptides; Phosphates; Porphyrins; Potentiometry; Propionates; Protein Conformation; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Thermus thermophilus; Tyrosine; Water | 1999 |
Geminate recombination of nitric oxide to endothelial nitric-oxide synthase and mechanistic implications.
Topics: Arginine; Biopterins; Heme; Humans; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Photolysis; Recombinant Proteins; Spectrum Analysis | 1999 |
[Clinical manifestations and diagnosis of acute porphyria].
Topics: Acute Disease; Adult; Arginine; Critical Care; Diagnosis, Differential; Female; Glucose; Heme; Humans; Infusions, Intravenous; Male; Middle Aged; Porphyrias; Pregnancy; Quality of Life; Respiration, Artificial | 1999 |
Reaction of neuronal nitric oxide synthase with the nitric oxide spin-trapping agent, iron complexed with N-dithiocarboxysarcosine.
Topics: Animals; Arginine; Citrulline; Electron Spin Resonance Spectroscopy; Electron Transport; Enzyme Inhibitors; Ferric Compounds; Heme; In Vitro Techniques; Iron; Mice; NADP; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxygen Consumption; Spin Labels; Swine; Thiocarbamates | 1999 |
Acute intermittent porphyria with central pontine myelinolysis and cortical laminar necrosis.
Topics: Adult; Arginine; Brain; Female; Fluid Therapy; Heme; Humans; Hyponatremia; Myelinolysis, Central Pontine; Necrosis; Porphyria, Acute Intermittent; Saline Solution, Hypertonic; Seizures; Vasospasm, Intracranial | 1999 |
Coupled oxidation of heme covalently attached to cytochrome b562 yields a novel biliprotein.
Topics: Arginine; Bacterial Proteins; Biliverdine; Cloning, Molecular; Cysteine; Cytochrome b Group; Escherichia coli; Escherichia coli Proteins; Heme; Histidine; Hydrolysis; Methionine; Mutagenesis, Site-Directed; Nuclear Magnetic Resonance, Biomolecular; Oxidation-Reduction; Pyrroles; Tetrapyrroles | 1999 |
Mutation of Arg-54 strongly influences heme composition and rate and directionality of electron transfer in Paracoccus denitrificans cytochrome c oxidase.
Topics: Arginine; Chromatography, High Pressure Liquid; Electron Transport; Electron Transport Complex IV; Heme; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Oxidation-Reduction; Paracoccus denitrificans; Spectrum Analysis | 1999 |
Interaction between the formyl group of heme a and arginine 54 in cytochrome aa(3) from Paracoccus denitrificans.
Topics: Arginine; Electron Transport Complex IV; Heme; Hydrogen Bonding; Models, Molecular; Paracoccus denitrificans; Static Electricity | 2000 |
Formation of a pterin radical in the reaction of the heme domain of inducible nitric oxide synthase with oxygen.
Topics: Arginine; Biopterins; Electron Spin Resonance Spectroscopy; Free Radicals; Heme; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Oxygen; Pterins | 1999 |
Functional properties of the heme propionates in cytochrome c oxidase from Paracoccus denitrificans. Evidence from FTIR difference spectroscopy and site-directed mutagenesis.
Topics: Amino Acid Substitution; Arginine; Electron Transport Complex IV; Heme; Histidine; Hydrogen Bonding; Mutagenesis, Site-Directed; Oxidation-Reduction; Paracoccus denitrificans; Propionates; Recombinant Proteins; Spectroscopy, Fourier Transform Infrared; Tryptophan; Tyrosine | 2000 |
Structural consequences of b- to c-type heme conversion in oxidized Escherichia coli cytochrome b562.
Topics: Amino Acid Sequence; Arginine; Cysteine; Cytochrome b Group; Cytochrome c Group; Electron Spin Resonance Spectroscopy; Enzyme Stability; Escherichia coli; Escherichia coli Proteins; Heme; Molecular Sequence Data; Mutagenesis, Site-Directed; Nuclear Magnetic Resonance, Biomolecular; Oxidation-Reduction; Protein Structure, Secondary; Solutions | 2000 |
Formation and reactions of the heme-dioxygen intermediate in the first and second steps of nitric oxide synthesis as studied by stopped-flow spectroscopy under single-turnover conditions.
Topics: Animals; Arginine; Catalysis; Citrulline; Ferrous Compounds; Heme; Kinetics; Models, Chemical; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitrites; Oxygen; Rats; Spectrophotometry | 2000 |
Mutations in the putative H-channel in the cytochrome c oxidase from Rhodobacter sphaeroides show that this channel is not important for proton conduction but reveal modulation of the properties of heme a.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Arginine; Cattle; Electron Transport Complex IV; Enzyme Activation; Glutamine; Heme; Histidine; Lysine; Molecular Sequence Data; Mutagenesis, Site-Directed; Proton Pumps; Rhodobacter sphaeroides; Spectrum Analysis, Raman; Tyrosine | 2000 |
Nitric oxide-induced autoinhibition of neuronal nitric oxide synthase in the presence of the autoxidation-resistant pteridine 5-methyltetrahydrobiopterin.
Topics: Animals; Arginine; Biopterins; Catalase; Catalysis; Cattle; Citrulline; Dimerization; Free Radical Scavengers; Guanylate Cyclase; Heme; Hydrogen Peroxide; NADP; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidants; Pteridines; Rats; Superoxide Dismutase; Superoxides | 2000 |
Structures of the N(omega)-hydroxy-L-arginine complex of inducible nitric oxide synthase oxygenase dimer with active and inactive pterins.
Topics: Animals; Arginine; Binding Sites; Biopterins; Catalysis; Crystallography, X-Ray; Dimerization; Heme; Hydrogen Bonding; Iron; Mice; Models, Chemical; Models, Molecular; Molecular Sequence Data; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Oxygen; Oxygenases; Protein Conformation; Structure-Activity Relationship | 2000 |
Formation of two types of low-spin heme in horseradish peroxidase isoenzyme A2 at low temperature.
Topics: Arginine; Cold Temperature; Electron Spin Resonance Spectroscopy; Heme; Histidine; Horseradish Peroxidase; Hydrogen Bonding; Hydrogen-Ion Concentration; Isoenzymes; Protein Conformation; Spectrophotometry, Infrared | 2000 |
Ferriporphyrins and endothelium: a 2-edged sword-promotion of oxidation and induction of cytoprotectants.
Topics: Arginine; Cell Survival; Cells, Cultured; Deuteroporphyrins; Endothelium, Vascular; Ferric Compounds; Ferritins; Gene Expression Regulation; Heme; Heme Oxygenase (Decyclizing); Hemin; Humans; Hydrogen Peroxide; Lipoproteins, LDL; Neutrophils; Oxidation-Reduction; RNA, Messenger; Tetradecanoylphorbol Acetate; Thiobarbituric Acid Reactive Substances; Transcription, Genetic; Umbilical Veins | 2000 |
Aromatic residues and neighboring Arg414 in the (6R)-5,6,7, 8-tetrahydro-L-biopterin binding site of full-length neuronal nitric-oxide synthase are crucial in catalysis and heme reduction with NADPH.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Arginine; Binding Sites; Biopterins; Catalysis; Dimerization; Drosophila; Glutamine; Heme; Humans; Hydrogen Bonding; Leucine; Mice; Models, Molecular; Molecular Sequence Data; NADP; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidation-Reduction; Phenylalanine; Rats; Spectrophotometry, Atomic; Structure-Activity Relationship; Tryptophan | 2000 |
Characterization of interactions among the heme center, tetrahydrobiopterin, and L-arginine binding sites of ferric eNOS using imidazole, cyanide, and nitric oxide as probes.
Topics: Animals; Arginine; Binding, Competitive; Biopterins; Catalysis; Cattle; Computer Simulation; Cyanides; Escherichia coli; Ferric Compounds; Flavins; Genetic Vectors; Heme; Humans; Imidazoles; Ligands; Models, Chemical; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Protein Binding | 2000 |
Arginine conversion to nitroxide by tetrahydrobiopterin-free neuronal nitric-oxide synthase. Implications for mechanism.
Topics: Arginine; Biopterins; Catalysis; Citrulline; Heme; Hydrogen Peroxide; NADP; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidation-Reduction | 2000 |
Rapid kinetic studies link tetrahydrobiopterin radical formation to heme-dioxy reduction and arginine hydroxylation in inducible nitric-oxide synthase.
Topics: Animals; Arginine; Biopterins; Catalysis; Enzyme Activation; Free Radicals; Heme; Hydroxylation; Kinetics; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidants; Oxidation-Reduction; Oxygen; Oxygenases; Protein Structure, Tertiary; Recombinant Proteins; Reducing Agents; Spectrophotometry | 2001 |
Hereditary coproporphyria in Germany: clinical-biochemical studies in 53 patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Arginine; Child; Chromatography, High Pressure Liquid; Coproporphyrinogen Oxidase; Coproporphyrins; Feces; Female; Germany; Heme; Heterozygote; Humans; Isomerism; Male; Middle Aged; Porphobilinogen; Porphyrias, Hepatic; Uroporphyrins | 2000 |
A positively charged cluster formed in the heme-distal pocket of cytochrome P450nor is essential for interaction with NADH.
Topics: Amino Acid Sequence; Arginine; Binding Sites; Bromides; Camphor 5-Monooxygenase; Crystallography, X-Ray; Cytochrome P-450 Enzyme System; Heme; Kinetics; Lysine; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; Nitric Oxide; Oxidoreductases; Phosphates; Protein Structure, Secondary; Sequence Homology, Amino Acid; Spectrophotometry | 2001 |
Inhibition of neuronal nitric oxide synthase by N-phenacyl imidazoles.
Topics: Adult; Animals; Arginine; Borohydrides; Enzyme Inhibitors; Heme; Humans; Imidazoles; Isoenzymes; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrobenzenes; Rats; Recombinant Fusion Proteins; Substrate Specificity | 2001 |
Administration of heme arginate, but not hematin, caused anaphylactic shock.
Topics: Adult; Anaphylaxis; Arginine; Female; Heme; Hemin; Humans; Porphyria, Acute Intermittent | 2001 |
Electron and proton transfer in the arginine-54-methionine mutant of cytochrome c oxidase from Paracoccus denitrificans.
Topics: Arginine; Biological Transport; Copper; Electron Transport; Electron Transport Complex IV; Heme; Kinetics; Membrane Potentials; Methionine; Mutagenesis, Site-Directed; Oxygen; Paracoccus denitrificans; Phospholipids; Photolysis; Protons; Spectrophotometry | 2001 |
Calmodulin activates intersubunit electron transfer in the neuronal nitric-oxide synthase dimer.
Topics: Animals; Arginine; Calmodulin; Dimerization; Electron Transport; Escherichia coli; Heme; Iron; Models, Biological; NADP; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Point Mutation; Protein Subunits; Rats; Transfection | 2001 |
Zinc mesoporphyrin represses induced hepatic 5-aminolevulinic acid synthase and reduces heme oxygenase activity in a mouse model of acute hepatic porphyria.
Topics: 5-Aminolevulinate Synthetase; Acute Disease; Aminolevulinic Acid; Animals; Arginine; Cytosol; Drug Combinations; Female; Heme; Heme Oxygenase (Decyclizing); Injections, Intraperitoneal; Liver; Metalloporphyrins; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Phenobarbital; Porphyria, Acute Intermittent; Porphyrias, Hepatic; Reference Values; RNA, Messenger | 2001 |
Haem arginate interferes with estimation of carcinoembryonic antigen.
Topics: Adult; alpha-Fetoproteins; Arginine; Carcinoembryonic Antigen; Carcinoma, Hepatocellular; Chemistry, Clinical; Erythrocytes; False Positive Reactions; Female; Heme; Hemoglobins; Humans; Porphyrias, Hepatic; Prostate-Specific Antigen | 2001 |
X-ray absorption spectroscopic analysis of the high-spin ferriheme site in substrate-bound neuronal nitric-oxide synthase.
Topics: Animals; Arginine; Biopterins; Catalytic Domain; Cations, Divalent; Copper; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Heme; Humans; Ligands; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Spectrum Analysis; X-Rays | 2001 |
Kinetics of CO binding to the haem domain of murine inducible nitric oxide synthase: differential effects of haem domain ligands.
Topics: Animals; Arginine; Carbon Monoxide; Cloning, Molecular; Escherichia coli; Heme; Kinetics; Ligands; Light; Mice; Models, Chemical; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Photolysis; Protein Binding; Protein Isoforms; Protein Structure, Tertiary; Recombinant Proteins; Recombination, Genetic; Spectrophotometry; Time Factors | 2001 |
A conserved tryptophan in nitric oxide synthase regulates heme-dioxy reduction by tetrahydrobiopterin.
Topics: Animals; Arginine; Biopterins; Conserved Sequence; Electron Spin Resonance Spectroscopy; Electrons; Heme; Kinetics; Light; Mice; Models, Chemical; Mutation; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxygen; Protein Binding; Spectrophotometry; Time Factors; Tryptophan | 2001 |
Neuronal nitric oxide synthase generates superoxide from the oxygenase domain.
Topics: Animals; Arginine; Catalysis; DNA, Complementary; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Heme; Mice; Mutation; Neurons; Nitric Oxide Synthase; Oxidation-Reduction; Oxygenases; Protein Binding; Protein Structure, Tertiary; Recombinant Proteins; Sodium Cyanide; Spin Trapping; Superoxides; Time Factors | 2001 |
Nitric oxide (NO) traffic in endothelial NO synthase. Evidence for a new NO binding site dependent on tetrahydrobiopterin?
Topics: Arginine; Binding Sites; Biopterins; Dose-Response Relationship, Drug; Heme; Humans; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Protein Binding; Recombinant Proteins; Spectrophotometry; Time Factors | 2002 |
Critical role of the neuronal nitric-oxide synthase heme proximal side residue, Arg418, in catalysis and electron transfer.
Topics: Amino Acid Sequence; Animals; Arginine; Binding Sites; Catalysis; Electron Transport; Heme; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; NADP; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidation-Reduction; Rats; Spectrophotometry | 2001 |
Cloning, expression, and characterization of a nitric oxide synthase protein from Deinococcus radiodurans.
Topics: Amino Acid Sequence; Animals; Arginine; Biopterins; Catalysis; Citrulline; Cloning, Molecular; Dimerization; Dithiothreitol; Dose-Response Relationship, Drug; Electrons; Heme; Hydrogen Peroxide; Kinetics; Ligands; Models, Chemical; Models, Molecular; Molecular Sequence Data; NADP; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Thermus; Time Factors; Zinc | 2002 |
Perferryl complex of nitric oxide synthase: role in secondary free radical formation.
Topics: Arginine; Binding Sites; Carbon Radioisotopes; Citrulline; Electron Spin Resonance Spectroscopy; Ethanol; Free Radicals; Heme; Humans; Iron; NADP; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidation-Reduction; Potassium Compounds; Recombinant Proteins; Sodium Cyanide; Spin Trapping; Sulfates | 2002 |
Reactions catalyzed by the heme domain of inducible nitric oxide synthase: evidence for the involvement of tetrahydrobiopterin in electron transfer.
Topics: Arginine; Base Sequence; Biopterins; Catalysis; Chromatography, Gel; DNA Primers; Electron Transport; Heme; Molecular Weight; Nitric Oxide Synthase; Nitric Oxide Synthase Type II | 2002 |
Binding of L-arginine and imidazole suggests heterogeneity of rat brain neuronal nitric oxide synthase.
Topics: Animals; Arginine; Binding, Competitive; Biopterins; Cell Line; Heme; Humans; Imidazoles; Kinetics; Mice; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Spectrophotometry, Ultraviolet; Spodoptera; Titrimetry; Tumor Cells, Cultured | 2002 |
Alteration of the heme prosthetic group of neuronal nitric-oxide synthase during inactivation by N(G)-amino-L-arginine in vitro and in vivo.
Topics: Animals; Arginine; Cells, Cultured; Enzyme Inhibitors; Heme; Humans; Insecta; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Transfection | 2002 |
["Acute intermittent porphyria" diagnosis. An odyssey in diagnosis].
Topics: Abdominal Pain; Arginine; Colic; Diagnosis, Differential; Heme; Humans; Porphyria, Acute Intermittent | 2002 |
EPR and ENDOR characterization of intermediates in the cryoreduced oxy-nitric oxide synthase heme domain with bound L-arginine or N(G)-hydroxyarginine.
Topics: Arginine; Binding Sites; Electron Spin Resonance Spectroscopy; Freezing; Heme; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidation-Reduction; Oxygen; Protein Structure, Tertiary; Protons; Substrate Specificity | 2002 |
A molecular, enzymatic and clinical study in a family with hereditary coproporphyria.
Topics: Adult; Aminolevulinic Acid; Arginine; Coproporphyrinogen Oxidase; DNA Mutational Analysis; Feces; Female; Heme; Humans; Porphyrias; Protein Denaturation | 2002 |
Atypical attack of acute intermittent porphyria--paresis but no abdominal pain.
Topics: Abdominal Pain; Adult; Arginine; Disease Progression; Estradiol; Female; Heme; Humans; Hysterectomy; Middle Aged; Ovariectomy; Paresis; Periodicity; Porphyria, Acute Intermittent; Progesterone; Recurrence | 2002 |
Structure-based mechanism of O2 sensing and ligand discrimination by the FixL heme domain of Bradyrhizobium japonicum.
Topics: Arginine; Bacterial Proteins; Bradyrhizobium; Carbon Monoxide; Crystallography, X-Ray; Cyanides; Ferric Compounds; Ferrous Compounds; Heme; Hemeproteins; Histidine Kinase; Hydrogen Bonding; Imidazoles; Isomerism; Ligands; Oxidation-Reduction; Oxygen; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Structure-Activity Relationship | 2002 |
The antithyroid agent 6-n-propyl-2-thiouracil is a mechanism-based inactivator of the neuronal nitric oxide synthase isoform.
Topics: Animals; Antithyroid Agents; Arginine; Biopterins; Calcium; Calmodulin; Carbon Monoxide; Carbon Radioisotopes; Citrulline; Enzyme Activation; Enzyme Inhibitors; Heme; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pituitary Neoplasms; Propylthiouracil; Rats; Thiouracil; Tumor Cells, Cultured | 2002 |
Fine-tuning of the binding and dissociation of CO by the amino acids of the heme pocket of Coprinus cinereus peroxidase.
Topics: Amino Acid Substitution; Amino Acids; Anions; Arginine; Asparagine; Aspartic Acid; Carbon Monoxide; Coprinus; Cytochrome-c Peroxidase; Ferrous Compounds; Heme; Kinetics; Ligands; Mutation; Peroxidase; Phenylalanine; Protein Binding; Spectrophotometry, Infrared; Spectrum Analysis, Raman | 2002 |
High-resolution structure and biochemical properties of a recombinant Proteus mirabilis catalase depleted in iron.
Topics: Acetates; Anions; Arginine; Binding Sites; Catalase; Catalysis; Crystallography, X-Ray; Heme; Hydrogen Bonding; Iron; Models, Molecular; NADP; Protein Conformation; Proteus mirabilis; Protoporphyrins; Recombinant Proteins; Spectrum Analysis; Sulfates | 2003 |
Structure of tetrahydrobiopterin tunes its electron transfer to the heme-dioxy intermediate in nitric oxide synthase.
Topics: Animals; Arginine; Biopterins; Catalysis; Crystallization; Crystallography, X-Ray; Electron Transport; Free Radicals; Heme; Isoenzymes; Kinetics; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Oxygen; Protein Binding; Pterins; Spectrophotometry, Ultraviolet; Structure-Activity Relationship | 2003 |
Two modes of binding of N-hydroxyguanidines to NO synthases: first evidence for the formation of iron-N-hydroxyguanidine complexes and key role of tetrahydrobiopterin in determining the binding mode.
Topics: Arginine; Binding Sites; Biopterins; Catalysis; Electron Spin Resonance Spectroscopy; Guanidines; Heme; Hydroxylamines; Iron; Kinetics; Ligands; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidation-Reduction; Oxygen; Protein Binding; Spectrum Analysis, Raman; Structure-Activity Relationship | 2003 |
An electrical potential in the access channel of catalases enhances catalysis.
Topics: Arginine; Aspartic Acid; Catalase; Catalysis; Electrochemistry; Escherichia coli; Heme; Mutagenesis, Site-Directed; Protein Structure, Tertiary; Valine | 2003 |
Characterization of Drosophila nitric oxide synthase: a biochemical study.
Topics: Animals; Arginine; Biopterins; Dose-Response Relationship, Drug; Drosophila; Electrons; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Heme; Hydrogen Peroxide; Hydrolysis; NADP; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Open Reading Frames; Protein Structure, Tertiary; Spectrophotometry; Time Factors; Trypsin; Ultraviolet Rays; Urea | 2003 |
[Clinical manifestations of porphyrin metabolism disorders].
Topics: Acute Disease; Adolescent; Adult; Arginine; Chronic Disease; Female; Heme; Humans; Inosine Diphosphate; Middle Aged; Octreotide; Plasmapheresis; Porphyria, Acute Intermittent; Porphyria, Erythropoietic; Porphyrias; Porphyrins | 2003 |
Solvent dependent and independent motions of CO-horseradish peroxidase examined by infrared spectroscopy and molecular dynamics calculations.
Topics: Arginine; Binding Sites; Carbon Monoxide; Heme; Histidine; Horseradish Peroxidase; Hydrogen-Ion Concentration; Hydroxamic Acids; Models, Molecular; Movement; Solvents; Spectrophotometry, Infrared; Temperature | 2003 |
Ability of tetrahydrobiopterin analogues to support catalysis by inducible nitric oxide synthase: formation of a pterin radical is required for enzyme activity.
Topics: Amino Acids; Arginine; Binding Sites; Biopterins; Catalysis; Dithionite; Electron Spin Resonance Spectroscopy; Enzyme Activation; Free Radicals; Freezing; Heme; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Oxyhemoglobins; Protein Structure, Tertiary; Pterins; Recombinant Proteins; Time Factors | 2003 |
Effects of site-directed mutations on heme reduction in Escherichia coli nitrate reductase A by menaquinol: a stopped-flow study.
Topics: Arginine; Electron Transport; Escherichia coli Proteins; Heme; Histidine; Hydroxyquinolines; Mutagenesis, Site-Directed; Naphthols; Nitrate Reductase; Nitrate Reductases; Nitrates; Oxidation-Reduction; Polyenes; Spectrometry, Fluorescence; Terpenes; Tyrosine; Vitamin K | 2003 |
1H-NMR study of dynamics and thermodynamics of Cl- binding to ferric hemoglobin of a midge larva (Tokunagayusurika akamusi).
Topics: Animals; Arginine; Binding Sites; Chironomidae; Chlorides; Heme; Hydrogen-Ion Concentration; Kinetics; Larva; Methemoglobin; Nuclear Magnetic Resonance, Biomolecular; Thermodynamics | 2003 |
Hemoglobin hydrolysis and heme acquisition by Porphyromonas gingivalis.
Topics: Adhesins, Bacterial; Arginine; Cysteine Endopeptidases; Gingipain Cysteine Endopeptidases; Hemagglutinins; Heme; Hemoglobins; Humans; Hydrogen-Ion Concentration; Hydrolysis; Lysine; Mutation; Peptide Fragments; Porphyromonas gingivalis; Protein Binding; Virulence Factors | 2004 |
Evidence of two distinct oxygen complexes of reduced endothelial nitric oxide synthase.
Topics: Animals; Arginine; Binding Sites; Cattle; Dose-Response Relationship, Drug; Heme; Kinetics; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxygen; Protein Structure, Tertiary; Pterins; Spectrophotometry; Superoxides; Temperature | 2004 |
Mixed regioselectivity in the Arg-177 mutants of Corynebacterium diphtheriae heme oxygenase as a consequence of in-plane heme disorder.
Topics: Amino Acid Substitution; Animals; Arginine; Bacterial Proteins; Binding Sites; Catalysis; Corynebacterium diphtheriae; Gene Expression Regulation, Enzymologic; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hydrogen Bonding; Isomerism; Mutagenesis, Site-Directed; Nuclear Magnetic Resonance, Biomolecular; Protein Conformation; Rats; Spectrophotometry, Ultraviolet; Static Electricity; Substrate Specificity; Thermodynamics | 2004 |
Role of the conserved arginine pair in proton and electron transfer in cytochrome C oxidase.
Topics: Alanine; Arginine; Catalysis; Conserved Sequence; Electron Spin Resonance Spectroscopy; Electron Transport; Electron Transport Complex IV; Enzyme Activation; Glutamine; Heme; Kinetics; Lysine; Magnesium; Mutagenesis, Site-Directed; Photolysis; Proline; Proton Pumps; Rhodobacter sphaeroides; Spectrophotometry, Ultraviolet | 2004 |
Three different oxygen-induced radical species in endothelial nitric-oxide synthase oxygenase domain under regulation by L-arginine and tetrahydrobiopterin.
Topics: Amino Acids; Arginine; Biopterins; Catalysis; Cytochromes c; Electron Spin Resonance Spectroscopy; Free Radicals; Heme; Humans; Kinetics; Models, Chemical; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Normal Distribution; Oxygen; Oxygenases; Protein Structure, Tertiary; Proteins; Reactive Oxygen Species; Recombinant Proteins; Spectrophotometry; Superoxides; Time Factors | 2004 |
Involvement of a Glu71-Arg64 couple in the access channel for NADH in cytochrome p450nor.
Topics: Amino Acid Substitution; Arginine; Aspartic Acid; Cytochrome P-450 Enzyme System; Fusarium; Glutamic Acid; Heme; Molecular Structure; NAD; Oxidoreductases; Point Mutation | 2004 |
Crystal structure of the ascorbate peroxidase-salicylhydroxamic acid complex.
Topics: Arginine; Ascorbate Peroxidases; Binding Sites; Crystallography, X-Ray; Glycine max; Heme; Iron; Models, Molecular; Molecular Structure; Peroxidases; Protein Structure, Tertiary; Protons; Protoporphyrins; Salicylamides; Spectrophotometry | 2004 |
The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-A resolution.
Topics: Arginine; Binding Sites; Crystallography, X-Ray; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Heme; Humans; Kinetics; Microsomes; Models, Molecular; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Substrate Specificity | 2004 |
Stability of the heme environment of the nitric oxide synthase from Staphylococcus aureus in the absence of pterin cofactor.
Topics: Amino Acid Sequence; Animals; Arginine; Carbon Monoxide; Electrons; Heme; Humans; Molecular Sequence Data; Nitric Oxide Synthase; Protein Structure, Tertiary; Protons; Pterins; Sequence Homology, Amino Acid; Spectrophotometry; Spectrum Analysis, Raman; Staphylococcus aureus; Static Electricity; Tetrahydrofolates | 2004 |
Refractory status epilepticus due to acute hepatic porphyria in a pregnant woman: induced abortion as the sole therapeutic option?
Topics: Abortion, Induced; Adult; Arginine; Brain Mapping; Diffusion Magnetic Resonance Imaging; Electroencephalography; Female; Frontal Lobe; Heme; Humans; Porphyrias, Hepatic; Porphyrins; Pregnancy; Status Epilepticus; Time Factors | 2004 |
Arginine 391 in subunit I of the cytochrome bd quinol oxidase from Escherichia coli stabilizes the reduced form of the hemes and is essential for quinol oxidase activity.
Topics: Amino Acid Sequence; Arginine; Binding Sites; Carbon Monoxide; Catalysis; Chromatography, High Pressure Liquid; Cytochrome b Group; Cytochromes; Electron Spin Resonance Spectroscopy; Electron Transport Chain Complex Proteins; Escherichia coli; Escherichia coli Proteins; Heme; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; NADPH Oxidases; Oxidation-Reduction; Oxidoreductases; Oxygen; Potentiometry; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; Structure-Activity Relationship; Tetramethylphenylenediamine; Ubiquinone | 2004 |
Redox function of tetrahydrobiopterin and effect of L-arginine on oxygen binding in endothelial nitric oxide synthase.
Topics: Animals; Arginine; Biopterins; Cattle; Ferric Compounds; Ferrous Compounds; Free Radicals; Heme; Humans; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidation-Reduction; Oxygen; Protein Binding; Protein Structure, Tertiary; Recombinant Proteins; Spodoptera; Two-Hybrid System Techniques | 2004 |
Bilirubin from heme oxygenase-1 attenuates vascular endothelial activation and dysfunction.
Topics: Animals; Aorta; Aorta, Thoracic; Arginine; Bilirubin; Endothelial Cells; Endothelium, Vascular; Enzyme Induction; Gene Expression Profiling; Gene Expression Regulation; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; In Vitro Techniques; Inflammation; Lipoproteins, LDL; Membrane Proteins; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oligonucleotide Array Sequence Analysis; Tumor Necrosis Factor-alpha; Vasodilation | 2005 |
Thermodynamic and kinetic analysis of the nitrosyl, carbonyl, and dioxy heme complexes of neuronal nitric-oxide synthase. The roles of substrate and tetrahydrobiopterin in oxygen activation.
Topics: Arginine; Catalysis; Dimerization; Electrochemistry; Ferric Compounds; Ferrous Compounds; Heme; Hydrogen Bonding; Kinetics; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidation-Reduction; Oxygen; Potentiometry; Thermodynamics; Titrimetry | 2005 |
Endoproteolytic cleavage of human thyroperoxidase: role of the propeptide in the protein folding process.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Arginine; Autoantigens; Biotinylation; Brefeldin A; CHO Cells; Cricetinae; Cysteine; Cytoplasm; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Furin; Gene Deletion; Glycosylation; Heme; Humans; Immunoprecipitation; Iodide Peroxidase; Iron-Binding Proteins; Lysine; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Models, Genetic; Molecular Chaperones; Molecular Sequence Data; Monensin; Mutagenesis; Mutagenesis, Site-Directed; Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase; Peptides; Protein Folding; Protein Processing, Post-Translational; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Thyroid Gland; Time Factors; Transfection | 2005 |
Cytochrome b6 arginine 214 of Synechococcus sp. PCC 7002, a key residue for quinone-reductase site function and turnover of the cytochrome bf complex.
Topics: Alleles; Animals; Arginine; Binding Sites; Chlamydomonas; Cyanobacteria; Cytochrome b6f Complex; Cytochromes b6; Electrochemistry; Electrons; Heme; Hydrogen; Kinetics; Models, Biological; Models, Genetic; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Oxidation-Reduction; Oxygen; Phenotype; Plasmids; Plastoquinone; Polymerase Chain Reaction; Protein Structure, Tertiary; Quinones; Spectrophotometry; Synechococcus; Time Factors | 2005 |
The three nitric-oxide synthases differ in their kinetics of tetrahydrobiopterin radical formation, heme-dioxy reduction, and arginine hydroxylation.
Topics: Animals; Arginine; Biopterins; Free Radicals; Heme; Humans; Hydroxylation; Kinetics; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidation-Reduction; Rats | 2005 |
An analysis of 112 acute porphyric attacks in Cape Town, South Africa: Evidence that acute intermittent porphyria and variegate porphyria differ in susceptibility and severity.
Topics: Abdominal Pain; Acute Disease; Adult; Age Factors; Arginine; Epidemiologic Methods; Female; Heme; Humans; Hypertension; Male; Porphyria, Acute Intermittent; Porphyria, Variegate; Precipitating Factors; Psychotic Disorders; Remission, Spontaneous; Sex Factors; South Africa; Tachycardia | 2005 |
Role of arginine 220 in the oxygen sensor FixL from Bradyrhizobium japonicum.
Topics: Arginine; Bacterial Proteins; Bradyrhizobium; Carbon Monoxide; DNA; Electrons; Heme; Hemeproteins; Histidine Kinase; Hydrogen Bonding; Hypoxia; Kinetics; Ligands; Models, Chemical; Models, Molecular; Mutation; Oxygen; Protein Conformation; Protein Structure, Tertiary; Signal Transduction; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Time Factors; Ultraviolet Rays | 2005 |
ED presentation of acute porphyria.
Topics: Abdominal Pain; Adolescent; Adult; Age of Onset; Analgesia; Arginine; Diagnostic Errors; Emergency Medicine; Emergency Service, Hospital; Female; Glucose; Heme; Humans; Hyponatremia; Infusions, Intravenous; Male; Middle Aged; Porphyria, Acute Intermittent; Retrospective Studies; Seizures; Taiwan; Treatment Outcome | 2005 |
Ligand, cofactor, and residue vibrations in the catalytic site of endothelial nitric oxide synthase.
Topics: Animals; Arginine; Carbon Monoxide; Catalytic Domain; Cattle; Coenzymes; Deuterium Exchange Measurement; Heme; Kinetics; Ligands; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Nitrogen; Nitrogen Isotopes; Nitrogen Radioisotopes; Photolysis; Spectroscopy, Fourier Transform Infrared; Thermodynamics | 2005 |
A tryptophan that modulates tetrahydrobiopterin-dependent electron transfer in nitric oxide synthase regulates enzyme catalysis by additional mechanisms.
Topics: Animals; Arginine; Biopterins; Catalysis; Dimerization; Electron Transport; Enzyme Stability; Ferrous Compounds; Heme; Hydroxylation; Isoenzymes; Kinetics; Mice; Mutagenesis, Site-Directed; NADP; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Oxidation-Reduction; Protein Binding; Rats; Spectrophotometry; Tryptophan | 2005 |
The histidine of the c-type cytochrome CXXCH haem-binding motif is essential for haem attachment by the Escherichia coli cytochrome c maturation (Ccm) apparatus.
Topics: Amino Acid Substitution; Arginine; Binding Sites; Cytochrome b Group; Cytochromes c; Escherichia coli; Escherichia coli Proteins; Heme; Histidine; Lysine; Mutation; Protein Binding | 2005 |
Molecular basis of intramolecular electron transfer in sulfite-oxidizing enzymes is revealed by high resolution structure of a heterodimeric complex of the catalytic molybdopterin subunit and a c-type cytochrome subunit.
Topics: Amino Acid Sequence; Arginine; Catalysis; Catalytic Domain; Cytochrome Reductases; Cytochromes; Electron Transport; Electrons; Gene Expression Regulation, Bacterial; Heme; Models, Molecular; Molecular Sequence Data; Oxygen; Protein Conformation; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Static Electricity; Sulfite Dehydrogenase; Sulfites; Xanthobacter | 2005 |
Prevention of hemorrhagic shock-induced lung injury by heme arginate treatment in rats.
Topics: Animals; Arginine; Dose-Response Relationship, Drug; Heat-Shock Proteins; Heme; Heme Oxygenase (Decyclizing); Lung; Male; Oxygenases; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Shock, Hemorrhagic; Tumor Necrosis Factor-alpha | 2005 |
Determination of carbon monoxide (CO) in rodent tissue: effect of heme administration and environmental CO exposure.
Topics: Animals; Arginine; Carbon Monoxide; Chromatography, Gas; Environmental Exposure; Heme; Male; Mice; Mice, Inbred BALB C; Rats; Rats, Wistar | 2005 |
Probing the stability and structure of metalloporphyrin complexes with basic peptides by mass spectrometry.
Topics: Arginine; Heme; Ions; Ligands; Lysine; Mass Spectrometry; Metalloporphyrins; Peptide Fragments; Protein Binding; Structure-Activity Relationship | 2005 |
Gating of proton and water transfer in the respiratory enzyme cytochrome c oxidase.
Topics: Animals; Arginine; Biological Transport; Cattle; Computer Simulation; Electron Transport Complex IV; Heme; Ion Channel Gating; Mutagenesis, Site-Directed; Paracoccus denitrificans; Propionates; Proton Pumps; Water | 2005 |
An arginine to lysine mutation in the vicinity of the heme propionates affects the redox potentials of the hemes and associated electron and proton transfer in cytochrome c oxidase.
Topics: Animals; Arginine; Electron Transport; Electron Transport Complex IV; Enzyme Activation; Heme; Horses; Kinetics; Lysine; Mutagenesis, Site-Directed; Oxidation-Reduction; Propionates; Proton Pumps; Rhodobacter sphaeroides; Static Electricity | 2005 |
Water chain formation and possible proton pumping routes in Rhodobacter sphaeroides cytochrome c oxidase: a molecular dynamics comparison of the wild type and R481K mutant.
Topics: Arginine; Computer Simulation; Electron Transport Complex IV; Glutamic Acid; Heme; Hydrogen Bonding; Lysine; Models, Molecular; Mutagenesis, Site-Directed; Propionates; Protein Structure, Secondary; Proton Pumps; Rhodobacter sphaeroides; Thermodynamics; Water | 2005 |
C-terminal tail residue Arg1400 enables NADPH to regulate electron transfer in neuronal nitric-oxide synthase.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Arginine; Base Sequence; Calmodulin; DNA, Complementary; Electron Transport; Heme; Humans; In Vitro Techniques; Kinetics; Models, Biological; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; NADP; Nitric Oxide; Nitric Oxide Synthase Type I; Oxidation-Reduction; Protein Conformation; Protein Structure, Tertiary; Rats; Recombinant Proteins; Sequence Homology, Amino Acid | 2005 |
A molecular switch and electronic circuit modulate catalase activity in catalase-peroxidases.
Topics: Arginine; Bacterial Proteins; Binding Sites; Burkholderia pseudomallei; Catalase; Crystallography, X-Ray; Electronics; Heme; Hydrogen Peroxide; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Models, Molecular; Oxidation-Reduction; Peroxidases; Protein Conformation; Water | 2005 |
Metabolism of aminoguanidine, diaminoguanidine, and NG-amino-L-arginine by neuronal NO-synthase and covalent alteration of the heme prosthetic group.
Topics: Arginine; Cells, Cultured; Enzyme Activation; Gas Chromatography-Mass Spectrometry; Guanidines; Heme; Models, Chemical; Molecular Structure; Nitric Oxide Synthase Type I | 2005 |
Reactivity of the heme-dioxygen complex of the inducible nitric oxide synthase in the presence of alternative substrates.
Topics: Animals; Arginine; Biopterins; Guanidines; Heme; Kinetics; Mice; Models, Chemical; Nitric Oxide Synthase Type II; Oxygen; Substrate Specificity | 2006 |
Alteration of the regiospecificity of human heme oxygenase-1 by unseating of the heme but not disruption of the distal hydrogen bonding network.
Topics: Arginine; Binding Sites; Catalysis; Crystallography, X-Ray; Heme; Heme Oxygenase-1; Humans; Hydrogen Bonding; Kinetics; Lysine; Magnetic Resonance Spectroscopy; Mutation; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Protein Conformation; Time Factors | 2006 |
Regulation of the monomer-dimer equilibrium in inducible nitric-oxide synthase by nitric oxide.
Topics: Amino Acid Motifs; Animals; Arginine; Biopterins; Chelating Agents; Chromatography; Cysteine; Dimerization; Disulfides; Escherichia coli; Heme; Iron; Mass Spectrometry; Mice; Models, Chemical; Models, Molecular; Molecular Conformation; Nitric Oxide; Nitric Oxide Synthase Type II; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Spectrophotometry; Spectrum Analysis, Raman; Structure-Activity Relationship; Sulfhydryl Compounds; Time Factors; Urea; Zinc | 2006 |
Design, synthesis, and biological testing of potential heme-coordinating nitric oxide synthase inhibitors.
Topics: Animals; Arginine; Chromatography, High Pressure Liquid; Computer Simulation; Drug Design; Enzyme Inhibitors; Heme; Inhibitory Concentration 50; Mice; Molecular Structure; Nitric Oxide Synthase; Rats; Spectrum Analysis; Structure-Activity Relationship; Substrate Specificity | 2006 |
A weak Fe-O bond in the oxygenated complex of the nitric-oxide synthase of Staphylococcus aureus.
Topics: Arginine; Binding Sites; Catalysis; Electrons; Ferrous Compounds; Heme; Iron; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Oxygen; Spectrophotometry; Spectrum Analysis, Raman; Staphylococcus aureus; Time Factors | 2006 |
Roles of the heme distal residues of FixL in O2 sensing: a single convergent structure of the heme moiety is relevant to the downregulation of kinase activity.
Topics: Arginine; Bacterial Proteins; Binding Sites; Cyanides; Down-Regulation; Heme; Hemeproteins; Histidine Kinase; Hydrogen Bonding; Imidazoles; Iron; Isoleucine; Kinetics; Ligands; Magnetic Resonance Spectroscopy; Mutation; Oxidation-Reduction; Oxygen; Phosphorylation; Protein Conformation; Protein Kinases; Sinorhizobium meliloti; Spectrum Analysis, Raman | 2006 |
Nitrosyl-heme structures of Bacillus subtilis nitric oxide synthase have implications for understanding substrate oxidation.
Topics: Arginine; Bacillus subtilis; Binding Sites; Catalysis; Crystallography, X-Ray; Ferric Compounds; Ferrous Compounds; Heme; Hemoglobins; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Oxidoreductases; Oxygen; Protein Structure, Tertiary; Substrate Specificity | 2006 |
Role of distal arginine in early sensing intermediates in the heme domain of the oxygen sensor FixL.
Topics: Arginine; Bacterial Proteins; Carbon Monoxide; Heme; Hemeproteins; Histidine Kinase; Hydrogen Bonding; Kinetics; Oxygen; Spectrum Analysis | 2006 |
[Laboratory tests and therapeutic strategies for the porphyrias].
Topics: Algorithms; Arginine; Critical Care; Diagnosis, Differential; Dose-Response Relationship, Drug; Drug Administration Schedule; Genetic Predisposition to Disease; Heme; Humans; Photosensitivity Disorders; Porphyria Cutanea Tarda; Porphyrias | 2006 |
Treatment of an acute attack of porphyria during pregnancy.
Topics: Abortion, Induced; Arginine; Female; Heme; Humans; Porphyria, Acute Intermittent; Pregnancy; Pregnancy Complications, Infectious | 2006 |
[Acute intermittent porphyria and oral contraception. Case report].
Topics: Adult; Arginine; Contraceptives, Oral, Synthetic; Desogestrel; Female; Glucose; Heme; Humans; Porphyria, Acute Intermittent; Saline Solution, Hypertonic; Treatment Outcome | 2006 |
The role of tetrahydrobiopterin in catalysis by nitric oxide synthase.
Topics: Algorithms; Arginine; Binding Sites; Biopterins; Catalysis; Electron Transport; Heme; Molecular Structure; Nitric Oxide Synthase; Protons | 2006 |
Heme arginate pretreatment attenuates pulmonary NF-kappaB and AP-1 activation induced by hemorrhagic shock via heme oxygenase-1 induction.
Topics: Animals; Arginine; Electrophoretic Mobility Shift Assay; Enzyme Induction; Heme; Heme Oxygenase (Decyclizing); Lung; Male; NF-kappa B; Rats; Shock, Hemorrhagic; Transcription Factor AP-1 | 2006 |
Interactions between substrates and the haem-bound nitric oxide of ferric and ferrous bacterial nitric oxide synthases.
Topics: Animals; Arginine; Bacillus subtilis; Bacterial Proteins; DNA, Bacterial; Ferric Compounds; Ferrous Compounds; Heme; Kinetics; Nitric Oxide Synthase; Recombinant Proteins; Spectrum Analysis, Raman; Substrate Specificity | 2007 |
Characterization of carbon monoxide photodissociation from Fe(II)LPO with photoacoustic calorimetry.
Topics: Animals; Arginine; Binding Sites; Calorimetry; Carbon Monoxide; Cattle; Ferrous Compounds; Heme; Hydrogen-Ion Concentration; Lactoperoxidase; Milk; Photolysis; Propionates; Protein Conformation; Sodium Chloride; Thermodynamics | 2006 |
Roles of distal arginine in activity and stability of Coprinus cinereus peroxidase elucidated by kinetic and NMR analysis of the Arg51Gln, -Asn, -Leu, and -Lys mutants.
Topics: Amino Acid Substitution; Arginine; Catalytic Domain; Coprinus; Enzyme Stability; Heme; Hydrogen Bonding; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Nuclear Magnetic Resonance, Biomolecular; Oxidation-Reduction; Peroxidases; Spectrophotometry | 2007 |
Ursodesoxycholic acid and heme-arginate are unable to improve hematopoiesis and liver injury in an erythropoietic protoporphyria mouse model.
Topics: Animals; Arginine; Cholagogues and Choleretics; Disease Models, Animal; Hematopoiesis; Heme; Injections, Intraperitoneal; Liver; Mice; Mice, Transgenic; Protoporphyria, Erythropoietic; Ursodeoxycholic Acid | 2006 |
An IR study of protonation changes associated with heme-heme electron transfer in bovine cytochrome c oxidase.
Topics: Animals; Arginine; Carbon Monoxide; Cattle; Electron Transport; Electron Transport Complex IV; Heme; Hydrogen-Ion Concentration; Molecular Structure; Photolysis; Protons; Spectrophotometry, Infrared | 2007 |
Unique peroxidase reaction mechanism in prostaglandin endoperoxide H synthase-2: compound I in prostaglandin endoperoxide H synthase-2 can be formed without assistance by distal glutamine residue.
Topics: Amino Acid Substitution; Arginine; Cyclooxygenase 2; Glutamine; Heme; Humans; Hydrogen Bonding; Iron; Membrane Proteins; Mutation, Missense; Peroxidase; Peroxides; Plant Proteins; Plants; Prostaglandin H2; Species Specificity; Spectrum Analysis, Raman; Structure-Activity Relationship | 2007 |
A natural variant of the heme-binding signature (R441C) resulting in complete loss of function of CYP2D6.
Topics: Amino Acid Sequence; Arginine; Binding Sites; Chromatography, High Pressure Liquid; Consensus Sequence; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Gene Frequency; Genotype; Heme; Heterozygote; Humans; Models, Molecular; Polymorphism, Single Nucleotide; Propafenone; Protein Binding; Recombinant Proteins; Sequence Homology, Amino Acid; Sparteine | 2007 |
Substrate-specific interactions with the heme-bound oxygen molecule of nitric-oxide synthase.
Topics: Arginine; Bacillus subtilis; Biochemistry; Catalysis; Heme; Hydrogen Bonding; Kinetics; Ligands; Models, Chemical; Nitric Oxide Synthase; Oxygen; Spectrophotometry; Spectrum Analysis, Raman; Staphylococcus aureus; Substrate Specificity | 2007 |
Impact of two novel mutations on the structure and function of human myeloperoxidase.
Topics: Aminolevulinic Acid; Arginine; Calnexin; Calreticulin; Endoplasmic Reticulum; Glycine; Heme; Humans; K562 Cells; Kidney; Models, Molecular; Mutation, Missense; Oxygen; Peroxidase; Peroxidases | 2007 |
Oxygenase domain of Drosophila melanogaster nitric oxide synthase: unique kinetic parameters enable a more efficient NO release.
Topics: Animals; Arginine; Biopterins; Buffers; Catalysis; Computer Simulation; Drosophila melanogaster; Edetic Acid; Escherichia coli; Ferrous Compounds; Heme; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Oxygenases; Protein Structure, Tertiary; Spectrophotometry, Ultraviolet; Temperature | 2007 |
[Management of pregnancy in women with acute porphyria. Case reports].
Topics: Adult; Arginine; Female; Follow-Up Studies; Heme; Humans; Infant, Newborn; Male; Porphobilinogen; Porphyria, Acute Intermittent; Porphyrins; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Risk Factors | 2007 |
[Favorable outcome of acute porphyric neuropathy after treatment with heme arginate].
Topics: Adult; Arginine; Electrodiagnosis; Electrophysiology; Female; Heme; Humans; Laparoscopy; Motor Neuron Disease; Nervous System Diseases; Neural Conduction; Ovarian Cysts; Peripheral Nerves; Porphyria, Acute Intermittent; Postoperative Complications; Quadriplegia | 2007 |
The N-end rule pathway is a sensor of heme.
Topics: 3T3 Cells; Amino Acid Sequence; Aminoacyltransferases; Animals; Arginine; Binding Sites; Catalysis; Cysteine; Heme; Hemin; Mice; Models, Biological; Molecular Sequence Data; Nitric Oxide; Oxygen; Peptides; Saccharomyces cerevisiae; Substrate Specificity; Transcription, Genetic | 2008 |
A density functional theory investigation on the mechanism of the second half-reaction of nitric oxide synthase.
Topics: Arginine; Binding Sites; Citrulline; Computer Simulation; Heme; Models, Chemical; Molecular Structure; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Oxygen; Quantum Theory | 2008 |
Hemin arginate-induced heme oxygenase 1 expression improves liver microcirculation and mediates an anti-inflammatory cytokine response after hemorrhagic shock.
Topics: Animals; Anti-Inflammatory Agents; Arginine; Cytokines; Heat-Shock Proteins; Heme; Heme Oxygenase-1; Hemorrhage; Interleukin-10; Liver; Male; Microcirculation; Rats; Rats, Sprague-Dawley; Shock, Hemorrhagic; Tumor Necrosis Factor-alpha | 2008 |
Roles of Arg-97 and Phe-113 in regulation of distal ligand binding to heme in the sensor domain of Ec DOS protein. Resonance Raman and mutation study.
Topics: Amino Acid Substitution; Arginine; Carbon Monoxide; Carrier Proteins; Escherichia coli; Escherichia coli Proteins; Heme; Hydrogen Bonding; Ligands; Models, Molecular; Mutagenesis, Site-Directed; Mutation, Missense; Nitric Oxide; Phenylalanine; Phosphoric Diester Hydrolases; Protein Structure, Tertiary; Spectrum Analysis, Raman | 2008 |
Regulation of eNOS-derived superoxide by endogenous methylarginines.
Topics: Arginine; Biopterins; Electron Spin Resonance Spectroscopy; Heme; Humans; NADP; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Superoxides | 2008 |
Arg97 at the heme-distal side of the isolated heme-bound PAS domain of a heme-based oxygen sensor from Escherichia coli (Ec DOS) plays critical roles in autoxidation and binding to gases, particularly O2.
Topics: Arginine; Carbon Monoxide; Carrier Proteins; Crystallography, X-Ray; Cyclic GMP; Escherichia coli Proteins; Ferric Compounds; Ferrous Compounds; Heme; Iron; Models, Molecular; Mutagenesis, Site-Directed; Nitric Oxide; Oxidation-Reduction; Oxygen; Phosphoric Diester Hydrolases; Protein Binding; Protein Structure, Tertiary; Structure-Activity Relationship | 2008 |
Is the bound substrate in nitric oxide synthase protonated or neutral and what is the active oxidant that performs substrate hydroxylation?
Topics: Arginine; Catalytic Domain; Heme; Hydrogen Bonding; Hydroxylation; Isoenzymes; Models, Chemical; Models, Molecular; Nitric Oxide Synthase; Oxidants; Quantum Theory; Thermodynamics | 2008 |
Stabilization and characterization of a heme-oxy reaction intermediate in inducible nitric-oxide synthase.
Topics: Amino Acid Substitution; Animals; Arginine; Biopterins; Catalytic Domain; Crystallography, X-Ray; Electrochemistry; Free Radicals; Heme; Kinetics; Mice; Mutation, Missense; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidation-Reduction | 2008 |
Ligand binding to the Fe(III)-protoporphyrin IX complex of phosphodiesterase from Escherichia coli (Ec DOS) markedly enhances catalysis of cyclic di-GMP: roles of Met95, Arg97, and Phe113 of the putative heme distal side in catalytic regulation and ligand
Topics: Animals; Arginine; Catalysis; Cattle; Cyclic GMP; Escherichia coli Proteins; Ferric Compounds; Heme; Ligands; Methionine; Mutagenesis, Site-Directed; Phenylalanine; Phosphoric Diester Hydrolases; Protein Binding; Protein Structure, Tertiary; Protoporphyrins | 2008 |
Cytochrome P450 2C9 type II binding studies on quinoline-4-carboxamide analogues.
Topics: Arginine; Aryl Hydrocarbon Hydroxylases; Catalytic Domain; Chemistry, Pharmaceutical; Cytochrome P-450 CYP2C9; Drug Design; Heme; Humans; Imidazoles; Iron; Models, Molecular; Molecular Conformation; Protein Binding; Quinolines; Structure-Activity Relationship; Substrate Specificity | 2008 |
4,4-Difluorinated analogues of l-arginine and N(G)-hydroxy-l-arginine as mechanistic probes for nitric oxide synthase.
Topics: Arginine; Catalysis; Chemistry, Pharmaceutical; Drug Design; Fluorine; Heme; Models, Chemical; Nitric Oxide Synthase; Oxygen; Protein Isoforms; Protein Structure, Tertiary; Structure-Activity Relationship; Substrate Specificity | 2009 |
Role of substrate functional groups in binding to nitric oxide synthase.
Topics: Arginine; Carbon Monoxide; Heme; Hydrogen Bonding; Ligands; Nitric Oxide Synthase Type II; Spectrum Analysis, Raman; Substrate Specificity | 2009 |
Heme arginate suppresses cardiac lesions and hypertrophy in deoxycorticosterone acetate-salt hypertension.
Topics: Animals; Arginine; Cardiomegaly; Desoxycorticosterone; Disease Models, Animal; Heart; Heart Diseases; Heme; Heme Oxygenase (Decyclizing); Hypertension; Hypertrophy, Left Ventricular; Male; MAP Kinase Kinase 4; Mesoporphyrins; Myocardium; NF-kappa B; Rats; Rats, Sprague-Dawley; Transcription Factor AP-1; Transforming Growth Factor beta | 2009 |
Critical structural role of R481 in cytochrome c oxidase from Rhodobacter sphaeroides.
Topics: Arginine; Catalytic Domain; Electron Transport Complex IV; Heme; Hydrogen Bonding; Mutant Proteins; Mutation; Oxidation-Reduction; Rhodobacter sphaeroides; Spectrum Analysis, Raman; Structure-Activity Relationship | 2009 |
The acute porphyrias: a diagnostic and therapeutic challenge in internal and emergency medicine.
Topics: Arginine; Diagnostic Errors; Emergency Medicine; Heme; Humans; Internal Medicine; Porphyria, Acute Intermittent | 2009 |
Properties of Arg481 mutants of the aa3-type cytochrome c oxidase from Rhodobacter sphaeroides suggest that neither R481 nor the nearby D-propionate of heme a3 is likely to be the proton loading site of the proton pump.
Topics: Arginine; Bacterial Proteins; Catalytic Domain; Electrochemistry; Electron Transport Complex IV; Heme; Mutagenesis, Site-Directed; Oxidation-Reduction; Propionates; Proton Pumps; Rhodobacter sphaeroides; Spectroscopy, Fourier Transform Infrared | 2009 |
Safe and probably safe drugs in acute hepatic porphyria.
Topics: 5-Aminolevulinate Synthetase; Arginine; Drug-Related Side Effects and Adverse Reactions; Heme; Humans; Liver Transplantation; Porphyria, Acute Intermittent | 2009 |
The role of arginine-127 at the proximal NO-binding site in determining the electronic structure and function of 5-coordinate NO-heme in cytochrome c' of Rhodobacter sphaeroides.
Topics: Amino Acid Substitution; Arginine; Bacterial Proteins; Binding Sites; Cytochromes c'; Electron Spin Resonance Spectroscopy; Heme; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Nitric Oxide; Oxidation-Reduction; Recombinant Proteins; Rhodobacter sphaeroides; Spectrophotometry; Static Electricity | 2009 |
EPR and ENDOR characterization of the reactive intermediates in the generation of NO by cryoreduced oxy-nitric oxide synthase from Geobacillus stearothermophilus.
Topics: Arginine; Bacterial Proteins; Catalytic Domain; Citrulline; Electron Spin Resonance Spectroscopy; Ferrous Compounds; Geobacillus stearothermophilus; Heme; Models, Molecular; Nitric Oxide; Nitric Oxide Synthase; Nuclear Magnetic Resonance, Biomolecular; Oxidation-Reduction | 2009 |
Communication between R481 and Cu(B) in cytochrome bo(3) ubiquinol oxidase from Escherichia coli.
Topics: Arginine; Copper; Electron Transport Complex IV; Escherichia coli; Escherichia coli Proteins; Heme; Ubiquinone | 2009 |
Role of arginine guanidinium moiety in nitric-oxide synthase mechanism of oxygen activation.
Topics: Animals; Arginine; Binding Sites; Catalytic Domain; Citrulline; Enzyme Activation; Guanidine; Heme; Hydrogen Bonding; Mice; Models, Molecular; Molecular Structure; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidation-Reduction; Oxygen; Reactive Nitrogen Species; Reactive Oxygen Species; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman | 2010 |
[Effect of L-arginine on pro- and antioxidant status of the rat vessels and lungs in experimental rhabdomyolysis].
Topics: Animals; Antioxidants; Arginine; Blood Vessels; Catalase; Disease Models, Animal; Glycerol; Heme; Heme Oxygenase (Decyclizing); Lung; Male; Nitric Oxide Donors; Protein Carbonylation; Rats; Rats, Wistar; Rhabdomyolysis; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2009 |
[Neurological complications of acute intermittent porphyria precipitated by porphyrinogenic drugs and efficiency of heme-arginate treatment].
Topics: Acute Disease; Adolescent; Arginine; Electromyography; Famotidine; Female; Heme; Heme Oxygenase (Decyclizing); Humans; Nifedipine; Peripheral Nervous System Diseases; Phenobarbital; Porphyrias; Porphyrinogens; Time Factors | 2009 |
Heme-arginate suppresses phospholipase C and oxidative stress in the mesenteric arterioles of mineralcorticoid-induced hypertensive rats.
Topics: Animals; Arginine; Arterioles; Blood Pressure; Calcium; Cyclic GMP; Desoxycorticosterone; Dinoprost; Endothelin-1; Heme; Heme Oxygenase (Decyclizing); Hypertension; Inositol 1,4,5-Trisphosphate; Intracellular Fluid; Male; Mesenteric Arteries; Mineralocorticoids; NF-kappa B; Organometallic Compounds; Oxidative Stress; Rats; Rats, Sprague-Dawley; Second Messenger Systems; Sodium Chloride, Dietary; Type C Phospholipases; Up-Regulation | 2010 |
Heme arginate therapy enhanced adiponectin and atrial natriuretic peptide, but abated endothelin-1 with attenuation of kidney histopathological lesions in mineralocorticoid-induced hypertension.
Topics: Adiponectin; Animals; Arginine; Atrial Natriuretic Factor; Blood Pressure; Blotting, Western; Desoxycorticosterone; Disease Models, Animal; Endothelin-1; Heme; Heme Oxygenase (Decyclizing); Hypertension; Kidney; Kidney Diseases; Male; Mineralocorticoids; Rats; Rats, Sprague-Dawley | 2010 |
A retrospective analysis of outcome of pregnancy in patients with acute porphyria.
Topics: Abortion, Spontaneous; Adolescent; Adult; Arginine; Child; Female; Heme; Humans; Live Birth; London; Middle Aged; Porphyria, Acute Intermittent; Pregnancy; Pregnancy Complications; Retrospective Studies; Surveys and Questionnaires; Time Factors; Treatment Outcome; Young Adult | 2010 |
Pulsed EPR determination of the distance between heme iron and FMN centers in a human inducible nitric oxide synthase.
Topics: Arginine; Biocatalysis; Electron Spin Resonance Spectroscopy; Electron Transport; Ferric Compounds; Flavin Mononucleotide; Heme; Humans; Nitric Oxide; Nitric Oxide Synthase Type II | 2010 |
Short circuiting a sulfite oxidising enzyme with direct electrochemistry: active site substitutions and their effect on catalysis and electron transfer.
Topics: Amino Acid Substitution; Arginine; Catalytic Domain; Crystallography, X-Ray; Electrochemistry; Electron Transport; Genetic Variation; Heme; Histidine; Hydrogen-Ion Concentration; Models, Molecular; Oxidation-Reduction; Protein Conformation; Sulfite Dehydrogenase | 2011 |
The induction of macrophage hemeoxygenase-1 is protective during acute kidney injury in aging mice.
Topics: Acute Kidney Injury; Aging; Animals; Arginine; Cells, Cultured; Heme; Heme Oxygenase-1; Kidney; Macrophages; Membrane Proteins; Mice; Reperfusion Injury | 2011 |
Electron transfer pathways in cytochrome c oxidase.
Topics: Arginine; Binding Sites; Computational Biology; Copper; Electron Transport; Electron Transport Complex IV; Heme; Models, Molecular; Molecular Structure; Oxidation-Reduction; Oxygen; Protein Binding; Protein Structure, Tertiary; Protons; Quantum Theory; Water | 2011 |
Involvement of the distal Arg residue in Cl⁻ binding of midge larval haemoglobin.
Topics: Animals; Arginine; Chironomidae; Chlorine; Crystallography, X-Ray; Heme; Hemoglobins; Hydrogen-Ion Concentration; Insect Proteins; Larva; Molecular Dynamics Simulation; Protein Binding | 2011 |
Haem arginate as effective maintenance therapy for hereditary coproporphyria.
Topics: Abdominal Pain; Adult; Arginine; Coproporphyria, Hereditary; Female; Heme; Humans; Photosensitivity Disorders; Porphobilinogen; Severity of Illness Index; Treatment Outcome | 2011 |
Manipulating the proximal triad His-Asn-Arg in human myeloperoxidase.
Topics: Amino Acid Substitution; Arginine; Asparagine; Binding Sites; Cell Line; Cloning, Molecular; Ferric Compounds; Ferrous Compounds; Heme; Histidine; Humans; Models, Molecular; Mutant Proteins; Oxidation-Reduction; Peroxidase | 2011 |
Heme arginate potentiates latent HIV-1 reactivation while inhibiting the acute infection.
Topics: Acetylcysteine; Anti-HIV Agents; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Arginine; Cell Line; Heme; Heme Oxygenase-1; HIV-1; Humans; Jurkat Cells; Lectins, C-Type; Metalloporphyrins; Protoporphyrins; Proviruses; Reverse Transcription; Virus Activation; Virus Latency; Virus Replication | 2011 |
Spectroscopic, catalytic and binding properties of Bacillus subtilis NO synthase-like protein: comparison with other bacterial and mammalian NO synthases.
Topics: Animals; Arginine; Bacillus subtilis; Bacteria; Bacterial Proteins; Binding Sites; Biocatalysis; Biopterins; Citrulline; Ferric Compounds; Ferrous Compounds; Heme; Hydrogen Peroxide; Imidazoles; Kinetics; Mammals; Nitric Oxide Synthase; Oxidation-Reduction; Protein Binding; Recombinant Proteins; Species Specificity; Spectrophotometry | 2012 |
Mutation of Phe413 to Tyr in catalase KatE from Escherichia coli leads to side chain damage and main chain cleavage.
Topics: Arginine; Catalase; Crystallography, X-Ray; Escherichia coli; Genetic Variation; Heme; Hydrogen Peroxide; Kinetics; Mass Spectrometry; Models, Molecular; Molecular Conformation; Mutation; Oxygen; Phenylalanine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine | 2012 |
[The changes of metabolism in myocardium at ischemia-reperfusion and activating of the ATP-sensitive potassium channels].
Topics: Adenosine Triphosphate; Animals; Apoptosis; Arachidonic Acid; Arginase; Arginine; Dogs; Eicosanoids; Guanosine Triphosphate; Heme; KATP Channels; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardium; Nitrate Reductase (NADH); Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Pinacidil; Reactive Nitrogen Species; Reactive Oxygen Species; Reperfusion Injury | 2012 |
Acute intermittent porphyria: fatal complications of treatment.
Topics: Abdominal Pain; Adolescent; Analgesics; Arginine; Disease Management; Fatal Outcome; Female; Hallucinations; Heme; Humans; Hyponatremia; Monitoring, Physiologic; Porphobilinogen; Porphyria, Acute Intermittent; Water-Electrolyte Balance | 2012 |
Treatment with heme arginate alleviates adipose tissue inflammation and improves insulin sensitivity and glucose metabolism in a rat model of Human primary aldosteronism.
Topics: Adiposity; Animals; Arginine; Chemokine CCL2; Disease Models, Animal; Endothelin-1; Enzyme Activators; Gene Expression; Glucose; Heme; Heme Oxygenase (Decyclizing); Humans; Hyperaldosteronism; Insulin; Insulin Resistance; Intercellular Adhesion Molecule-1; Intra-Abdominal Fat; JNK Mitogen-Activated Protein Kinases; Male; Mesoporphyrins; NF-kappa B; Oxidative Stress; Rats; Rats, Sprague-Dawley; Signal Transduction; Transcription Factor AP-1 | 2012 |
Crystal structures of dye-decolorizing peroxidase with ascorbic acid and 2,6-dimethoxyphenol.
Topics: Arginine; Ascorbic Acid; Asparagine; Binding Sites; Coloring Agents; Crystallography, X-Ray; Heme; Hemeproteins; Hydrogen Bonding; Peroxidase; Protein Structure, Tertiary; Pyrogallol; Substrate Specificity; Water | 2012 |
Insights into the structural determinants for selective inhibition of nitric oxide synthase isoforms.
Topics: Aminopyridines; Arginine; Catalytic Domain; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Heme; Humans; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Protein Binding; Static Electricity | 2013 |
Roles of conserved Arg(72) and Tyr(71) in the ascorbate-specific transmembrane electron transfer catalyzed by Zea mays cytochrome b561.
Topics: Arginine; Ascorbic Acid; Binding Sites; Biocatalysis; Cytochrome b Group; Electron Transport; Heme; Lysine; Mutagenesis, Site-Directed; Tyrosine; Zea mays | 2013 |
Mechanism of inducible nitric-oxide synthase dimerization inhibition by novel pyrimidine imidazoles.
Topics: Amino Acid Substitution; Animals; Arginine; Biopterins; Cell Line; Enzyme Inhibitors; Heme; Imidazoles; Mice; Mutation, Missense; Nitric Oxide Synthase Type II; Protein Multimerization; Pyrimidines | 2013 |
A model of the membrane-bound cytochrome b5-cytochrome P450 complex from NMR and mutagenesis data.
Topics: Amino Acid Sequence; Animals; Arginine; Binding Sites; Biocatalysis; Cytochrome P-450 Enzyme System; Cytochromes b5; Electron Transport; Heme; Kinetics; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Multiprotein Complexes; Mutagenesis, Site-Directed; Mutation; Oxidation-Reduction; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Rabbits; Sequence Homology, Amino Acid; Substrate Specificity | 2013 |
Thermodynamic characterization of five key kinetic parameters that define neuronal nitric oxide synthase catalysis.
Topics: Animals; Arginine; Binding Sites; Biocatalysis; Computer Simulation; Ferrous Compounds; Heme; Kinetics; Models, Chemical; NADP; Neurons; Nitric Oxide; Nitric Oxide Synthase Type I; Oxidation-Reduction; Oxygen; Protein Binding; Rats; Temperature; Thermodynamics | 2013 |
Crystal structures of α-dioxygenase from Oryza sativa: insights into substrate binding and activation by hydrogen peroxide.
Topics: Arginine; Binding Sites; Catalytic Domain; Crystallography, X-Ray; Dioxygenases; Enzyme Activation; Heme; Histidine; Hydrogen Peroxide; Models, Molecular; Oryza; Palmitic Acid; Plant Proteins; Protein Structure, Tertiary; Substrate Specificity | 2013 |
Modulation of ligand-heme reactivity by binding pocket residues demonstrated in cytochrome c' over the femtosecond-second temporal range.
Topics: Arginine; Binding Sites; Crystallography, X-Ray; Cytochromes c; Heme; Humans; Kinetics; Leucine; Models, Chemical; Nitric Oxide; Photolysis; Protein Binding; Spectrophotometry, Infrared | 2013 |
Paradoxical effects of heme arginate on survival of myocutaneous flaps.
Topics: Animals; Arginine; Disease Models, Animal; Heme; Heme Oxygenase (Decyclizing); Myocutaneous Flap; Necrosis; Rats; Rats, Inbred Lew; Reperfusion Injury; Skin | 2014 |
Administration of heme arginate ameliorates murine type 2 diabetes independently of heme oxygenase activity.
Topics: 3T3 Cells; Adipocytes; Adipogenesis; Adiponectin; Adipose Tissue; Adiposity; Animals; Arginine; Blood Glucose; Cell Line; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Heme; Heme Oxygenase (Decyclizing); Hyperglycemia; Inflammation; Insulin-Secreting Cells; Metalloporphyrins; Mice; Pilot Projects | 2013 |
Heme oxygenase suppresses markers of heart failure and ameliorates cardiomyopathy in L-NAME-induced hypertension.
Topics: Adiponectin; Aldosterone; Animals; Antioxidants; Arginine; Atrial Natriuretic Factor; Biomarkers; Blood Pressure; Cardiomyopathies; Cardiotonic Agents; Chemokine CCL2; Chemokine CCL3; Cyclic GMP; Dinoprost; Endothelin-1; Enzyme Induction; Extracellular Matrix Proteins; Heart Failure; Heme; Heme Oxygenase (Decyclizing); Hypertension; Interleukin-1beta; Interleukin-6; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Tyrosine | 2014 |
Acute intermittent porphyria presenting as progressive muscular atrophy in a young black man.
Topics: Arginine; Heme; Humans; Hydroxymethylbilane Synthase; Male; Muscular Atrophy, Spinal; Porphyria, Acute Intermittent; Young Adult | 2014 |
Key roles of Arg(5), Tyr(10) and his residues in Aβ-heme peroxidase: relevance to Alzheimer's disease.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Arginine; Heme; Histidine; Humans; Mice; Molecular Sequence Data; Mutation; Oxidation-Reduction; Peptide Fragments; Peroxidases; Solutions; Tyrosine | 2014 |
Chaperone therapy for homocystinuria: the rescue of CBS mutations by heme arginate.
Topics: Animals; Arginine; Catalytic Domain; CHO Cells; Cricetulus; Cystathionine beta-Synthase; Female; Fibroblasts; Genetic Predisposition to Disease; Heme; Homocystinuria; Homozygote; Humans; Models, Molecular; Molecular Chaperones; Mutation; Phenotype; Protein Conformation; Protein Folding; Proteostasis Deficiencies; Structure-Activity Relationship; Substrate Specificity; Transfection | 2015 |
Heme Oxygenase Improves Renal Function by Potentiating Podocyte-Associated Proteins in Nω-Nitro-l-Arginine-Methyl Ester (l-NAME)-Induced Hypertension.
Topics: Animals; Arginine; Biomarkers; Cytoprotection; Disease Models, Animal; Enzyme Induction; Enzyme Inhibitors; Extracellular Matrix Proteins; Fibrosis; Heme; Heme Oxygenase (Decyclizing); Hypertension; Inflammation Mediators; Kidney; Male; Mesoporphyrins; NG-Nitroarginine Methyl Ester; Oxidative Stress; Podocytes; Rats, Sprague-Dawley; Signal Transduction | 2015 |
Dissecting structural and electronic effects in inducible nitric oxide synthase.
Topics: Amino Acid Substitution; Animals; Arginine; Biocatalysis; Dimerization; Enzyme Stability; Heme; Hydrogen Bonding; Hydroxylation; Kinetics; Mesoporphyrins; Mice; Models, Molecular; Mutant Proteins; Nitric Oxide; Nitric Oxide Synthase Type II; Peptide Fragments; Protein Conformation; Recombinant Proteins; Up-Regulation | 2015 |
A 17-year-old girl with chronic intermittent abdominal pain. Acute intermittent porphyria.
Topics: Abdominal Pain; Adolescent; Arginine; Cholelithiasis; Chronic Disease; Diagnosis, Differential; Female; Heme; Humans; Porphyria, Acute Intermittent; Porphyrins; Tomography, X-Ray Computed | 2015 |
Probing the Hydrogen Bonding of the Ferrous-NO Heme Center of nNOS by Pulsed Electron Paramagnetic Resonance.
Topics: Animals; Arginine; Catalysis; Catalytic Domain; Electron Spin Resonance Spectroscopy; Heme; Hydrogen; Hydrogen Bonding; Nitric Oxide; Nitric Oxide Synthase Type I; Protons; Rats; Water | 2015 |
The crystal structure of heme acquisition system A from Yersinia pseudotuberculosis (HasAypt): Roles of the axial ligand Tyr75 and two distal arginines in heme binding.
Topics: Arginine; Carrier Proteins; Crystallography, X-Ray; Heme; Heme-Binding Proteins; Hemeproteins; Ligands; Water; Yersinia pseudotuberculosis | 2015 |
A Biochemical Approach to Understand the Pathogenesis of Advanced Pulmonary Arterial Hypertension: Metabolomic Profiles of Arginine, Sphingosine-1-Phosphate, and Heme of Human Lung.
Topics: Adult; Arginine; Female; Heme; Humans; Hypertension, Pulmonary; Lung; Lysophospholipids; Male; Metabolic Networks and Pathways; Metabolomics; Middle Aged; Nitric Oxide; Sphingosine; Vascular Remodeling | 2015 |
Vascular and metabolic effects of the haem oxygenase-1 inducer haem arginate in subjects with the metabolic syndrome: A translational cross-over study.
Topics: Acetylcholine; Adult; Aged; Arginine; Bilirubin; Cross-Over Studies; Endothelium, Vascular; Female; Ferritins; Glucose Clamp Technique; Heme; Heme Oxygenase-1; Humans; Insulin Resistance; Male; Metabolic Syndrome; Middle Aged; Nitroglycerin; Random Allocation; RNA, Messenger; Translational Research, Biomedical; Vasodilation; Vasodilator Agents | 2016 |
Challenges in the successful management of a case of acute intermittent porphyria in India.
Topics: Abdominal Pain; Administration, Intravenous; Adolescent; Arginine; Heme; Humans; India; Male; Porphobilinogen; Porphyria, Acute Intermittent; Seizures; Treatment Outcome | 2016 |
Replacing Arginine 33 for Alanine in the Hemophore HasA from Pseudomonas aeruginosa Causes Closure of the H32 Loop in the Apo-Protein.
Topics: Alanine; Amino Acid Substitution; Apoproteins; Arginine; Bacterial Proteins; Carrier Proteins; Heme; Iron; Molecular Dynamics Simulation; Mutation, Missense; Nuclear Magnetic Resonance, Biomolecular; Protein Structure, Secondary; Pseudomonas aeruginosa | 2016 |
Dimerization of Arginyl-tRNA Synthetase by Free Heme Drives Its Inactivation in Plasmodium falciparum.
Topics: Amino Acid Sequence; Antimalarials; Arginine; Arginine-tRNA Ligase; Binding Sites; Chloroquine; Crystallography, X-Ray; Gene Expression; Heme; Hemin; Humans; Models, Molecular; Plasmodium falciparum; Protein Binding; Protein Biosynthesis; Protein Interaction Domains and Motifs; Protein Multimerization; Protein Structure, Secondary; Protozoan Proteins; Recombinant Proteins; RNA, Transfer, Arg; Sequence Alignment; Sequence Homology, Amino Acid; Species Specificity; Substrate Specificity | 2016 |
Tetrahydrobiopterin redox cycling in nitric oxide synthase: evidence supports a through-heme electron delivery.
Topics: Animals; Arginine; Biocatalysis; Biopterins; Electron Spin Resonance Spectroscopy; Electron Transport; Electrons; Free Radicals; Heme; Kinetics; Models, Molecular; Molecular Structure; Mutation; Nitric Oxide Synthase Type I; Oxidation-Reduction; Protein Binding; Protein Domains; Rats | 2016 |
Crystal structure and biochemical features of dye-decolorizing peroxidase YfeX from Escherichia coli O157 Asp
Topics: Arginine; Aspartic Acid; Calorimetry; Catalytic Domain; Cation Transport Proteins; Color; Crystallography, X-Ray; Escherichia coli O157; Escherichia coli Proteins; Heme; Hydrogen Peroxide; Substrate Specificity | 2017 |
Acute Intermittent Porphyria Presenting with Posterior Reversible Encephalopathy Syndrome, Accompanied by Prolonged Vasoconstriction.
Topics: Arginine; Female; Heme; Humans; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Porphyria, Acute Intermittent; Posterior Leukoencephalopathy Syndrome; Young Adult | 2017 |
Structural basis for binding and transfer of heme in bacterial heme-acquisition systems.
Topics: Amino Acid Motifs; Arginine; Binding Sites; Burkholderia cenocepacia; Chloroflexi; Cloning, Molecular; Crystallography, X-Ray; Escherichia coli; Gene Expression; Heme; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Iron; Models, Molecular; Periplasm; Periplasmic Binding Proteins; Plasmids; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Recombinant Proteins; Tyrosine | 2017 |
Proteomic Characterization of the Heart and Skeletal Muscle Reveals Widespread Arginine ADP-Ribosylation by the ARTC1 Ectoenzyme.
Topics: ADP Ribose Transferases; ADP-Ribosylation; Animals; Arginine; Carrier Proteins; Cell Line; Gene Ontology; Heme; Hemopexin; Isoenzymes; Male; Membrane Proteins; Mice; Mice, Knockout; Molecular Sequence Annotation; Muscle Fibers, Skeletal; Muscle Proteins; Muscle Weakness; Muscle, Skeletal; Myocardium; Protein Binding; Protein Processing, Post-Translational; Proteome; Proteomics; Signal Transduction | 2018 |
Unique Tyr-heme double cross-links in F43Y/T67R myoglobin: an artificial enzyme with a peroxidase activity comparable to that of native peroxidases.
Topics: Animals; Arginine; Benzothiazoles; Biomimetic Materials; Guaiacol; Heme; Histidine; Hydrogen Peroxide; Hydrogen-Ion Concentration; Kinetics; Molecular Structure; Mutation; Myoglobin; Oxidation-Reduction; Peroxidases; Protein Processing, Post-Translational; Sperm Whale; Sulfonic Acids; Tyrosine | 2019 |
Role of conserved arginine in the heme distal site of HutZ from Vibrio cholerae in the heme degradation reaction.
Topics: Arginine; Bacterial Proteins; Heme; Ligands; Mixed Function Oxygenases; Mutation; Oxidation-Reduction; Protein Binding; Vibrio cholerae; Water | 2019 |
Serial Femtosecond Zero Dose Crystallography Captures a Water-Free Distal Heme Site in a Dye-Decolorising Peroxidase to Reveal a Catalytic Role for an Arginine in Fe
Topics: Arginine; Biocatalysis; Coloring Agents; Crystallography, X-Ray; Heme; Iron Compounds; Models, Molecular; Oxidation-Reduction; Oxygen; Peroxidase; Streptomyces lividans | 2020 |
Non enzymatic covalent modification by glycolysis end product converts hemoglobin into its oxidative stress potency state.
Topics: Amyloidogenic Proteins; Arginine; Coloring Agents; Congo Red; Electron Spin Resonance Spectroscopy; Glycated Hemoglobin; Glycation End Products, Advanced; Glycolysis; Glycosylation; Heme; Hemoglobins; Humans; In Vitro Techniques; Lysine; Microscopy, Electron, Scanning; Oxidation-Reduction; Oxidative Stress; Protein Aggregates; Protein Conformation; Protein Structure, Secondary; Pyruvic Acid; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet | 2021 |
Arresting the Catalytic Arginine in Chlorite Dismutases: Impact on Heme Coordination, Thermal Stability, and Catalysis.
Topics: Arginine; Catalysis; Chlorides; Cyanothece; Enzyme Stability; Heme; Hydrogen Bonding; Kinetics; Models, Molecular; Oxidoreductases; Temperature | 2021 |
Dysregulation of homocysteine homeostasis in acute intermittent porphyria patients receiving heme arginate or givosiran.
Topics: Acetylgalactosamine; Adult; Arginine; Cystathionine beta-Synthase; Female; Folic Acid; Heme; Homeostasis; Homocysteine; Homocystinuria; Humans; Hydroxymethylbilane Synthase; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Porphyria, Acute Intermittent; Pyridoxal Phosphate; Pyrrolidines; Young Adult | 2021 |
Severe homocysteinemia in two givosiran-treated porphyria patients: is free heme deficiency the culprit?
Topics: 5-Aminolevulinate Synthetase; Acetylgalactosamine; Adult; Arginine; Colitis; Colon, Sigmoid; Controlled Clinical Trials as Topic; Drug Hypersensitivity; Female; Fibrosis; Heme; Hepatocytes; High-Throughput Nucleotide Sequencing; Homocysteine; Humans; Hydroxymethylbilane Synthase; Hyperhomocysteinemia; Male; Models, Biological; Pancreatitis; Porphyria, Acute Intermittent; Pyrrolidines | 2021 |
Safety of haem arginate in overdose: report of an uneventful fourfold accidental overdose.
Topics: Arginine; Drug Overdose; Heme; Humans | 2022 |
Hypochlorous acid facilitates inducible nitric oxide synthase subunit dissociation: The link between heme destruction, disturbance of the zinc-tetrathiolate center, and the prevention by melatonin.
Topics: Arginine; Heme; Humans; Hydrogen Peroxide; Hypochlorous Acid; Melatonin; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidoreductases; Oxygenases; Zinc | 2022 |
Intramolecular electron transfer from biopterin to Fe
Topics: Animals; Arginine; Bacillus subtilis; Biopterins; Electrons; Ferrous Compounds; Heme; Iron; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Pterins; Rats | 2023 |