arginine and heme arginate

arginine has been researched along with heme arginate in 112 studies

Research

Studies (112)

Timeframe	Studies, this research(%)	All Research%
pre-1990	23 (20.54)	18.7374
1990's	30 (26.79)	18.2507
2000's	32 (28.57)	29.6817
2010's	24 (21.43)	24.3611
2020's	3 (2.68)	2.80

Authors

Authors	Studies
Kauma, H; Timonen, TT	1
Fitzsimons, E; Houston, T; Jamieson, A; Moore, MR	1
Dover, SB; Fitzsimons, E; Graham, A; McColl, KE; Moore, MR	1
Abraham, NG; Goodman, AI; Levere, RD; Martasek, P; Schwartzman, ML; Solangi, KB	1
Gray, TA; Manning, DJ	1
Goldberg, A; Herrick, AL; McColl, KE; Moore, MR; Wallace, AM	1
Abraham, NG; Escalante, B; Levere, RD; Martasek, P; Schwartzman, ML	1
Lauharanta, J; Mustajoki, P; Tenhunen, R; Timonen, K	1
Abraham, NG; Lin, JH; Martasek, P; Villalon, P	1
Arnold, R; Beckh, K; Blanke, H; Doss, M; Sieg, I; Stellwaag, M	1
Green, D; Ts'ao, CH	1
Kordac, V; Kozáková, M; Martásek, P	1
Cook, A; Goldberg, A; Herrick, AL; McColl, KE; Moore, MR	1
Pierach, CA	1
Juvonen, E; Partanen, S; Ruutu, T; Tenhunen, R	1
Häkli, H; Luhtala, J; Sievers, G; Tenhunen, R	1
Karlsson, M; Lindén, IB; Tenhunen, R; Tokola, O	1
Brodie, MJ; Goldberg, A; Herrick, A; McColl, KE; McLellan, A; Moore, MR	1
Lindén, IB; Tenhunen, R; Tokola, O	2
Volin, L	1
Mustajoki, P; Tenhunen, R; Tokola, O; Volin, L	2
Bakchine, S; Derouesne, C; Fontaine, B; Laplane, D; Nordmann, Y	1
Kordac, V; Martásek, P	2
Cieslar, P; Kordac, V; Kornalík, F; Martásek, P; Spicka, I	1
Himberg, JJ; Mustajoki, P; Tokola, O	1
Rasi, V; Tenhunen, R; Vahtera, E; Volin, L	1
Knuutila, S; Ruutu, T; Tenhunen, R; Volin, L	1
Tokola, O	2
Ruutu, T; Tenhunen, R; Volin, L	1
Tenhunen, R	1
Aderka, D; Dotan, I; Levo, Y; Mamet, R; Schoenfeld, N; Sztern, M	1
Hentze, MW; Pantopoulos, K	1
Deybach, JC; Nordmann, Y; Puy, H	1
Arvela, P; Mustajoki, P; Mustajoki, S; Pelkonen, O; Rautio, A	1
Bharathi, KC; Mamatha, P; Muthane, UB; Vengamma, B	1
Dover, SB; Fitzsimmons, EJ; Graham, A; McColl, KE; Moore, MR	1
Chalevelakis, G; Yalouris, AG	1
Baudry, P; Callebert, J; Deybach, JC; Nordmann, Y; Puy, H; Touitou, Y	1
Mustajoki, P; Nordmann, Y	1
Deybach, JC; Nordmann, Y	1
Kottari, S; Pelkonen, O; Raunio, H; Salonpää, P	1
Battle, A; Fukuda, H; Riley, P; Washbrook, R	1
Mustajoki, P; Tenhunen, R	1
Deybach, JC; Doss, MO; Frank, M; Gross, U; Jacob, K; Nordmann, Y; Sassa, S	1
Ferrini, PR; Santini, V	1
Fibach, E; Friedberg, A; Goldfarb, A; Rachmilewitz, E; Rund, D	1
Karpova, IV; Pivnik, AV; Pustovoĭt, IaS	1
Daimon, M; Hirata, A; Kato, T; Kitagawa, M; Manaka, H; Morita, Y; Sasaki, H; Susa, S	1
Balla, G; Balla, J; Jacob, HS; Jeney, V; Kakuk, G; Vercellotti, GM	1
Doss, MO; Gross, U; Kühnel, A	1
Daimon, M; Igarashi, M; Kameda, W; Kato, T; Susa, S	1
Hoffmann, F; Lindberg, RL; Meyer, UA; Schuurmans, MM	1
Doss, M; Doss, MO; Gross, U; Schurek, JO	1
Elder, GH; Hift, RJ	1
Badminton, MN; Elder, GH	1
Deybach, JC; Doss, M; Doss, MO; Gross, U; Lamoril, J; Meissauer, U; Nordmann, Y; Puy, H	1
Andersson, C; Bäckström, T; Nilsson, A	1
Karpova, IV; Luchinina, IuA; Luk'ianenko, AV; Pivnik, AV; Pustovoĭt, IaS; Surin, VL	1
Hasui, Y; Ikeda, M; Tanabe, H	1
Beer, R; Engelhardt, K; Franz, G; Kampfl, A; Pfausler, B; Schmutzhard, E; Spiegel, M; Trinka, E; Unterberger, I	1
Ishikawa, K; Itabe, H; Kawamura, K; Kimura, S; Kodama, T; Kohro, T; Maruyama, Y; Matsumoto, H; Wada, Y	1
Hift, RJ; Meissner, PN	1
Chen, WJ; Fang, CC; Lai, TI; Lien, WC; Liu, YP; Wang, HP	1
Brand, HS; Kooijman, MM	1
Akagi, R; Maeshima, K; Morita, K; Omori, E; Shimizu, H; Takahashi, T; Tani, T; Uehara, K; Yokoyama, M	1
Kadotani, T; Stevenson, DK; Vreman, HJ; Wong, RJ	1
Frank, J; Merk, HF; Poblete-Gutiérrez, P; Wiederholt, T	1
Badminton, MN; Deybach, JC	1
Bianketti, J; Gregor, A; Lipniacka, A; Szlendak, U	1
Akagi, R; Maeshima, K; Morimatsu, H; Morita, K; Sasaki, T; Shimizu, H; Takahashi, T; Takeuchi, M; Toda, Y; Yokoyama, M	1
Abitbol, M; Deybach, JC; Guénet, JL; Montagutelli, X; Puy, H; Sabaté, JM	1
Feder, ZM; Ignashina, EV; Karpova, IV; Kravchenko, SK; Kremenetskaia, AM; Kurtser, MA; Mironova, TS; Murashko, LE; Petrova, VI; Pustovoĭt, IaS; Pustovoĭt, LA; Shmakov, RG; Shtabnitskiĭ, AM; Sokolova, MIu	1
Borie, MJ; Chauvet, MA; Corcia, P; Diot, E; Maillot, F; Zannad, N	1
Bauer, I; Heiser, J; Kubulus, D; Mathes, A; Pavlidis, D; Pradarutti, S; Raddatz, A; Rensing, H; Wolf, B	1
Andersson, DE; Floderus, Y; Harper, P; Sardh, E	1
Jadhav, A; Ndisang, JF	4
Cappellini, MD; Rocchi, E; Ventura, P	1
Brosche, C; Doss, MO; Koszka, C; Stauch, T; Stölzel, U; Teubner, A	1
Akopova-Larbi, R; Ben Youssef, TI; Gargouri, A; Gouider, R; Gouider-Khouja, N; Kraoua, I	1
Marsden, JT; Rees, DC	1
Andreas, M; Bilban, M; Clive, B; Doberer, D; Haschemi, A; Heinzl, H; Jeitler, M; Wagner, O; Wolzt, M; Zapf, TC	1
Beesley, MF; Choudhary, AK; Clay, S; Conway, BC; Ferenbach, DA; Hughes, J; Kluth, DC; Marson, LP; McKay, J; Nkejabega, NC; Vernon, MA	1
Ma, E; Mar, V; Nicoll, A; Ross, G; Varigos, G	1
Liskova, J; Melkova, Z; Shankaran, P; Vlkova, L	1
Badminton, MN; Barth, JH; Cox, TM; Rees, DC; Sarkany, R; Stein, PE; Stewart, MF	1
Andreas, M; Bilban, M; Doberer, D; Heinze, G; Moser, E; Schewzow, K; Schmid, AI; Weisshaar, S; Wolzt, M	1
Czopek, A; Edmunds, MC; Kluth, DC; Wigmore, SJ	1
Borthwick, G; Cairns, C; Choudhary, AK; Conway, BR; Hughes, J; Kluth, D; Morton, NM; Rennie, J	1
Chibbar, R; Lane, N; Ndisang, JF	1
Albertyn, CH; Bryer, A; Corrigall, A; Heckmann, JM; Meissner, P; Sonderup, M	1
Hnízda, A; Janošík, M; Kopecká, J; Kožich, V; Krijt, J; Melenovská, P; Raková, K; Wilcken, B	1
Chibbar, R; Ndisang, JF	1
Hergüner, Ö; Mungan, NÖ; Nazoglu, S; Öktem, M; Turgut, M; Yildizdas, D; Yilmaz, BS	1
Bilos, A; Dekker, D; Dorresteijn, MJ; Pennings, SW; Peters, WH; Smits, P; Wagener, FA	1
Dosi, R; Joshi, H; Patell, R; Shah, P; Tripathi, R	1
Bellamy, CO; Czopek, A; Kluth, DC; Marson, LP; McNally, SJ; Thomas, RA	1
Deguchi, K; Ikeda, K; Kamada, M; Kokudo, Y; Kume, K; Masaki, T; Takata, T; Touge, T	1
Barman-Aksözen, J; Huber, LC; Minder, E; Senn, JD	1
Andreas, M; Aref, T; Bilban, M; Heidtmann, J; Kainz, FM; Kocher, A; Laufer, G; Messner, B; Oeser, C; Shabanian, S; Wolzt, M	1
Beykirch, MK; Bronisch, O; Haverkamp, T; Petrides, PE; Stauch, T	1
Aarsand, AK; Aguilera, P; Brunet, M; Deulofeu, R; García-Villoria, J; Gómez-Gómez, À; Pozo, OJ; Sandberg, S; To-Figueras, J; Wijngaard, R	1
Beykirch, MK; Klein, M; Loehr, C; Molitor, B; Obermeier, Z; Petrides, PE; Schuhmann, E; Torkler, H	1
Bradberry, SM; Elamin, MEMO; McNally, D; Patel, NC; Stein, P; Wroe, N	1

Reviews

8 review(s) available for arginine and heme arginate

Article	Year
Hematin: effects on hemostasis. The Journal of laboratory and clinical medicine, 1990, Volume: 115, Issue:2 Topics: Arginine; Blood Coagulation; Heme; Hemin; Hemostasis; Humans; Molecular Structure; Sorbitol	1990
[Hepatic porphyrias and drugs]. Gastroenterologie clinique et biologique, 1994, Volume: 18, Issue:4 Topics: Acute Disease; Alanine; Arginine; Carbohydrates; Heme; Humans; Ligases; Porphyrias, Hepatic	1994
Differentiation therapy of myelodysplastic syndromes: fact or fiction? British journal of haematology, 1998, Volume: 102, Issue:5 Topics: Acetamides; Amifostine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Arginine; Azacitidine; Butyrates; Cholecalciferol; Cytarabine; Harringtonines; Hematopoietic Cell Growth Factors; Heme; Homoharringtonine; Humans; Interferons; Myelodysplastic Syndromes; Retinoids	1998
Treatment of acute porphyria. Hospital medicine (London, England : 1998), 2001, Volume: 62, Issue:7 Topics: Adolescent; Adult; Analgesics, Opioid; Arginine; Clinical Trials as Topic; Dietary Carbohydrates; Female; Heme; Humans; Male; Porphobilinogen; Porphyria, Acute Intermittent; Pregnancy; Pregnancy Complications; Treatment Outcome	2001
Management of acute and cutaneous porphyrias. International journal of clinical practice, 2002, Volume: 56, Issue:4 Topics: Arginine; beta Carotene; Chloroquine; Estrogens; Ethanol; Heme; Humans; Phlebotomy; Porphyria Cutanea Tarda; Porphyria, Acute Intermittent; Porphyrias; Sunlight	2002
[Porphyria]. Ryoikibetsu shokogun shirizu, 2003, Issue:40 Topics: 5-Aminolevulinate Synthetase; Analgesics, Opioid; Antipsychotic Agents; Arginine; Benzodiazepines; Ferrochelatase; Haloperidol; Heme; Humans; Hydroxymethylbilane Synthase; Olanzapine; Pirenzepine; Plasma Exchange; Porphyria, Acute Intermittent; Prognosis	2003
Oral aspects of porphyria. International dental journal, 2005, Volume: 55, Issue:2 Topics: Algorithms; Anesthesia, Dental; Arginine; Blister; Carbohydrates; Contraindications; Heme; Humans; Mouth Diseases; Photophobia; Porphobilinogen Synthase; Porphyria, Erythropoietic; Porphyrias, Hepatic; Tooth Discoloration	2005
[CME: Acute Intermittent Porphyria: When to Think of It? What Must be Checked? How to Treat?] Praxis, 2018, Volume: 107, Issue:3 Topics: Arginine; Combined Modality Therapy; Diagnosis, Differential; Female; Genetic Predisposition to Disease; Heme; Hemin; Humans; Interdisciplinary Communication; Intersectoral Collaboration; Middle Aged; Porphobilinogen; Porphyria, Acute Intermittent; Prognosis; Recurrence; Risk Factors	2018

Trials

9 trial(s) available for arginine and heme arginate

Article	Year
Haem-arginate plus tin-protoporphyrin for acute hepatic porphyria. Lancet (London, England), 1991, Jul-27, Volume: 338, Issue:8761 Topics: Adult; Arginine; Female; Heme; Humans; Liver Diseases; Metalloporphyrins; Porphyrias; Prospective Studies; Protoporphyrins	1991
Controlled trial of haem arginate in acute hepatic porphyria. Lancet (London, England), 1989, Jun-10, Volume: 1, Issue:8650 Topics: Acute Disease; Adolescent; Arginine; Clinical Trials as Topic; Double-Blind Method; Female; Heme; Heroin; Humans; Infusions, Intravenous; Injections, Intravenous; Liver Diseases; Male; Meperidine; Pain; Phlebitis; Porphyrias; Random Allocation; Recurrence; Severity of Illness Index	1989
Tin protoporphyrin prolongs the biochemical remission produced by heme arginate in acute hepatic porphyria. Gastroenterology, 1993, Volume: 105, Issue:2 Topics: Acute Disease; Adult; Arginine; Drug Synergism; Drug Therapy, Combination; Female; Heme; Humans; Male; Metalloporphyrins; Porphyrias, Hepatic; Protoporphyrins	1993
Plasma porphobilinogen as a sensitive biomarker to monitor the clinical and therapeutic course of acute intermittent porphyria attacks. European journal of internal medicine, 2009, Volume: 20, Issue:2 Topics: Acute Disease; Adult; Aminolevulinic Acid; Arginine; Biomarkers; Chromatography, Ion Exchange; Drug Monitoring; Female; Glucose; Heme; Humans; Male; Porphobilinogen; Porphyria, Acute Intermittent; Sensitivity and Specificity	2009
Haem arginate infusion stimulates haem oxygenase-1 expression in healthy subjects. British journal of pharmacology, 2010, Volume: 161, Issue:8 Topics: Adult; Arginine; Bilirubin; Dose-Response Relationship, Drug; Enzyme Induction; Haptoglobins; Heme; Heme Oxygenase-1; Hemopexin; Homozygote; Humans; Infusions, Intravenous; Male; Polymorphism, Genetic	2010
Heme arginate improves reperfusion patterns after ischemia: a randomized, placebo-controlled trial in healthy male subjects. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2012, Aug-02, Volume: 14 Topics: Adolescent; Adult; Arginine; Cross-Over Studies; Follow-Up Studies; Heme; Heme Oxygenase (Decyclizing); Humans; Infusions, Intravenous; Ischemia; Leg; Magnetic Resonance Imaging; Male; Muscle, Skeletal; Oxygen Consumption; Prospective Studies; Reference Values; Reperfusion Injury; Single-Blind Method; Treatment Outcome; Young Adult	2012
Hemin Preconditioning Upregulates Heme Oxygenase-1 in Deceased Donor Renal Transplant Recipients: A Randomized, Controlled, Phase IIB Trial. Transplantation, 2016, Volume: 100, Issue:1 Topics: Adult; Aged; Arginine; Biomarkers; Biopsy; Drug Administration Schedule; Enzyme Induction; Female; Heme; Heme Oxygenase-1; Humans; Kidney; Kidney Transplantation; Leukocytes, Mononuclear; Macrophages; Male; Middle Aged; RNA, Messenger; Scotland; Time Factors; Transplant Recipients; Treatment Outcome; Young Adult	2016
Intravenous Heme Arginate Induces HO-1 (Heme Oxygenase-1) in the Human Heart. Arteriosclerosis, thrombosis, and vascular biology, 2018, Volume: 38, Issue:11 Topics: Adult; Aged; Aged, 80 and over; Arginine; Austria; Carboxyhemoglobin; Dose-Response Relationship, Drug; Double-Blind Method; Enzyme Induction; Feasibility Studies; Female; Heme; Heme Oxygenase-1; Humans; Infusions, Intravenous; Leukocytes, Mononuclear; Male; Middle Aged; Myocardium; RNA, Messenger	2018
Acute porphyrias: a German monocentric study of the biochemical, molecular genetic, and clinical data of 62 families. Annals of hematology, 2019, Volume: 98, Issue:12 Topics: Adult; Anxiety; Arginine; Depression; Family; Female; Germany; Heme; Hospitalization; Humans; Male; Porphyria, Acute Intermittent; Prospective Studies; Quality of Life; Surveys and Questionnaires	2019

Other Studies

95 other study(ies) available for arginine and heme arginate

Article	Year
Therapeutic effect of heme arginate in myelodysplastic syndromes. European journal of haematology, 1992, Volume: 49, Issue:5 Topics: Adult; Aged; Alanine Transaminase; Arginine; Aspartate Aminotransferases; Bone Marrow; Creatinine; Erythropoietin; Female; Heme; Humans; Karyotyping; Male; Middle Aged; Myelodysplastic Syndromes	1992
Treatment of primary acquired sideroblastic anaemia with haem arginate. British journal of haematology, 1992, Volume: 80, Issue:2 Topics: 5-Aminolevulinate Synthetase; Aged; Aged, 80 and over; Anemia, Sideroblastic; Arginine; Heme; Humans	1992
Hemin and L-arginine regulation of blood pressure in spontaneous hypertensive rats. Journal of the American Society of Nephrology : JASN, 1991, Volume: 2, Issue:6 Topics: Animals; Arachidonic Acid; Arginine; Blood Pressure; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Dose-Response Relationship, Drug; Enzyme Induction; Heme; Heme Oxygenase (Decyclizing); Hemin; Hypertension; Kidney; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxygenases; Rats; Rats, Inbred SHR; Rats, Inbred WKY; RNA, Messenger	1991
Haem arginate in acute hereditary coproporphyria. Archives of disease in childhood, 1991, Volume: 66, Issue:6 Topics: Arginine; Child; Coproporphyrins; Heme; Humans; Liver Diseases; Male; Porphyrias	1991
Elevation of hormone-binding globulins in acute intermittent porphyria. Clinica chimica acta; international journal of clinical chemistry, 1990, Feb-28, Volume: 187, Issue:2 Topics: Adolescent; Adult; Aminolevulinic Acid; Arginine; Carrier Proteins; Heme; Humans; Hydrocortisone; Liver Diseases; Porphobilinogen; Porphyrias; Prospective Studies; Sex Hormone-Binding Globulin; Testosterone; Thyroxine-Binding Proteins	1990
Effect of heme arginate administration on blood pressure in spontaneously hypertensive rats. The Journal of clinical investigation, 1990, Volume: 86, Issue:1 Topics: Animals; Arachidonic Acid; Arachidonic Acids; Arginine; Blood Pressure; Blotting, Northern; Cytochrome P-450 Enzyme System; Gene Expression; Heme; Heme Oxygenase (Decyclizing); Hemin; Hypertension; Kidney; Liver; Mixed Function Oxygenases; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY; RNA, Messenger	1990
Effects of haem arginate on variegate porphyria. The British journal of dermatology, 1990, Volume: 123, Issue:3 Topics: Adult; Arginine; Feces; Female; Heme; Humans; Infusions, Intravenous; Photosensitivity Disorders; Porphyrias; Protoporphyrins; Skin; Skin Diseases	1990
Regulation of heme oxygenase gene expression by cobalt in rat liver and kidney. European journal of biochemistry, 1990, Sep-24, Volume: 192, Issue:3 Topics: Animals; Arginine; Cobalt; DNA; Enzyme Induction; Gene Expression Regulation, Enzymologic; Heme; Heme Oxygenase (Decyclizing); Kidney; Liver; Male; Nucleic Acid Hybridization; Plasmids; Protoporphyrins; Rats; Rats, Inbred Strains; RNA, Messenger; Transcription, Genetic	1990
[The coincidence of acute intermittent porphyria and Crohn's disease]. Deutsche medizinische Wochenschrift (1946), 1990, May-25, Volume: 115, Issue:21 Topics: Acute Disease; Adult; Arginine; Crohn Disease; Diagnosis, Differential; Drug Therapy, Combination; Glucose; Heme; Humans; Male; Porphyrias; Propranolol; Quadriplegia; Remission Induction	1990
Changes of myocardial functions in acute hepatic porphyrias. Role of heme arginate administration. Annals of medicine, 1989, Volume: 21, Issue:4 Topics: Acute Disease; Adult; Arginine; Cytochrome c Group; Female; Heart; Heme; Humans; Liver Diseases; Male; Middle Aged; Porphyrias	1989
Haem and porphyria attacks. Lancet (London, England), 1989, Jul-22, Volume: 2, Issue:8656 Topics: Arginine; Drug Evaluation; Heme; Humans; Porphyrias	1989
Effect of haem arginate on colony formation by haematopoietic progenitors in vitro. Scandinavian journal of clinical and laboratory investigation, 1989, Volume: 49, Issue:5 Topics: Arginine; Colony-Forming Units Assay; Heme; Humans; Lymphokines; Tissue Inhibitor of Metalloproteinases	1989
Optical and EPR spectroscopy studies on haem arginate, a new compound used for treatment of porphyria. Chemico-biological interactions, 1987, Volume: 63, Issue:2 Topics: Arginine; Electron Spin Resonance Spectroscopy; Heme; Humans; Mathematics; Molecular Weight; Porphyrias	1987
Fate of haem after parenteral administration of haem arginate to rabbits. The Journal of pharmacy and pharmacology, 1987, Volume: 39, Issue:2 Topics: Adrenal Glands; Animals; Arginine; Bile; Carbon Radioisotopes; Erythrocytes; Heme; Injections, Intramuscular; Injections, Intravenous; Iron Radioisotopes; Kinetics; Liver; Rabbits; Tissue Distribution	1987
Effect of haem arginate therapy on porphyrin metabolism and mixed function oxygenase activity in acute hepatic porphyria. Lancet (London, England), 1987, Nov-21, Volume: 2, Issue:8569 Topics: Acute Disease; Adult; Antipyrine; Arginine; Cytochrome P-450 Enzyme System; Depression, Chemical; Female; Heme; Humans; Hydroxymethylbilane Synthase; Leukocytes; Liver; Liver Diseases; Male; Mitochondria, Liver; Mixed Function Oxygenases; Porphobilinogen Synthase; Porphyrias; Porphyrins	1987
Haem arginate: a new stable haem compound. The Journal of pharmacy and pharmacology, 1987, Volume: 39, Issue:10 Topics: Animals; Arginine; Blood Coagulation; Blood Pressure; Drug Stability; Heme; Heme Oxygenase (Decyclizing); Hydrogen-Ion Concentration; Lethal Dose 50; Mice; Porphyrias; Spectrophotometry, Ultraviolet	1987
Haem arginate treatment for hereditary sideroblastic anaemia. European journal of haematology, 1989, Volume: 42, Issue:1 Topics: Adult; Anemia, Sideroblastic; Arginine; Erythrocyte Count; Erythrocytes; Female; Ferritins; Hematocrit; Heme; Humans; Iron; Transferrin	1989
Heme therapy. The American journal of medicine, 1989, Volume: 86, Issue:4 Topics: Arginine; Heme; Humans	1989
[Efficacy and tolerability of a new hematin in the treatment of an acute attack of porphyria]. Presse medicale (Paris, France : 1983), 1987, Feb-07, Volume: 16, Issue:4 Topics: Acute Disease; Adolescent; Arginine; Female; Heme; Humans; Porphyrias	1987
Haem arginate in acute hepatic porphyrias. British medical journal (Clinical research ed.), 1986, Oct-25, Volume: 293, Issue:6554 Topics: Acute Disease; Arginine; Heme; Humans; Liver Diseases; Porphyrias	1986
[The effect of heme arginate (Normosang Leiras--Medica) on hemostasis]. Casopis lekaru ceskych, 1988, Nov-11, Volume: 127, Issue:46 Topics: Arginine; Heme; Hemostasis; Humans; In Vitro Techniques	1988
Haem arginate improves hepatic oxidative metabolism in variegate porphyria. British journal of clinical pharmacology, 1988, Volume: 26, Issue:6 Topics: Adult; Antipyrine; Arginine; Feces; Female; Heme; Humans; Liver; Oxidation-Reduction; Porphyrias; Porphyrins	1988
Heme arginate: effects on hemostasis. Blood, 1988, Volume: 71, Issue:3 Topics: Adult; Arginine; Blood; Blood Coagulation; Blood Coagulation Factors; Blood Platelets; Female; Heme; Hemostasis; Humans; Male; Osmolar Concentration; Time Factors	1988
Heme arginate treatment for myelodysplastic syndromes. Leukemia research, 1988, Volume: 12, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Arginine; Blood Cell Count; Female; Heme; Humans; Karyotyping; Male; Middle Aged; Myelodysplastic Syndromes	1988
Barbiturate and ethanol sleeping times and pharmacokinetics of propranolol in mice after intravenous administration of haem arginate. Pharmacology & toxicology, 1987, Volume: 60, Issue:1 Topics: Animals; Arginine; Ethanol; Heme; Hexobarbital; Injections, Intravenous; Kinetics; Male; Mice; Propranolol; Sleep; Time Factors	1987
Haem arginate as a treatment for myelodysplastic syndromes. British journal of haematology, 1987, Volume: 65, Issue:4 Topics: Adult; Aged; Arginine; Bone Marrow; Female; Heme; Hemoglobins; Humans; Infusions, Intravenous; Leukocyte Count; Male; Myelodysplastic Syndromes; Neutrophils; Platelet Count	1987
Effects of repeated intravenous administration of haem arginate upon hepatic metabolism of foreign compounds in rats and dogs. British journal of pharmacology, 1987, Volume: 90, Issue:4 Topics: Animals; Arginine; Dogs; Heme; Infusions, Intravenous; Liver; Male; Pharmaceutical Preparations; Rats; Rats, Inbred Strains; Species Specificity	1987
The effects of haem arginate and haematin upon the allylisopropylacetamide induced experimental porphyria in rats. Pharmacology & toxicology, 1987, Volume: 61, Issue:1 Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Arginine; Heme; Hemin; Liver; Male; Porphobilinogen; Porphyrias; Rats; Rats, Inbred Strains	1987
[Treatment of acute intermittent porphyria. The first use of Heme-arginate in Czechoslovakia]. Casopis lekaru ceskych, 1987, Jul-24, Volume: 126, Issue:30 Topics: Acute Disease; Adult; Arginine; Heme; Humans; Male; Middle Aged; Porphyrias	1987
[A new drug for porphyria]. Nordisk medicin, 1986, Volume: 101, Issue:4 Topics: Arginine; Heme; Humans; Porphyrias	1986
Pharmacokinetics of intravenously administered haem arginate. British journal of clinical pharmacology, 1986, Volume: 22, Issue:3 Topics: Adult; Arginine; Female; Haptoglobins; Heme; Hemopexin; Humans; Injections, Intravenous; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; Porphyrias	1986
New treatment for porphyria to be studied. Journal of psychosocial nursing and mental health services, 1995, Volume: 33, Issue:5 Topics: Arginine; Female; Heme; Humans; Infusions, Intravenous; Male; Porphyrias	1995
Relation between uroporphyrin excretion, acute attacks of hereditary coproporphyria and successful treatment with haem arginate. Clinical science (London, England : 1979), 1995, Volume: 88, Issue:3 Topics: Acute Disease; Adult; Arginine; Erythrocytes; Heme; Humans; Hydroxymethylbilane Synthase; Male; Porphyrias, Hepatic; Porphyrins; Spectrometry, Fluorescence; Uroporphyrins	1995
Rapid responses to oxidative stress mediated by iron regulatory protein. The EMBO journal, 1995, Jun-15, Volume: 14, Issue:12 Topics: Aconitate Hydratase; Animals; Arginine; Cells, Cultured; Citrates; Citric Acid; Ethers, Cyclic; Ferritins; Fibroblasts; Heme; Hydrogen Peroxide; Iron-Regulatory Proteins; Mice; Okadaic Acid; Oxidative Stress; Phosphoprotein Phosphatases; Receptors, Transferrin; RNA-Binding Proteins; RNA, Messenger	1995
Effects of heme arginate on cytochrome P450-mediated metabolism of drugs in patients with variegate porphyria and in healthy men. Clinical pharmacology and therapeutics, 1994, Volume: 56, Issue:1 Topics: Adult; Arginine; Caffeine; Coumarins; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Heme; Humans; Isoenzymes; Lidocaine; Male; Middle Aged; Porphyrias, Hepatic; Reference Values	1994
Porphyric neuropathy: prevention of progression using haeme-arginate. Journal of internal medicine, 1993, Volume: 234, Issue:6 Topics: Adult; Arginine; Glucose Solution, Hypertonic; Heme; Humans; Male; Peripheral Nervous System Diseases; Porphyria, Acute Intermittent	1993
Haem administration in myelodysplastic syndromes: a possible mechanism of action. European journal of haematology, 1993, Volume: 51, Issue:1 Topics: alpha-Thalassemia; Arginine; beta-Thalassemia; Globins; Heme; Humans; Myelodysplastic Syndromes; Reticulocytes	1993
Decreased nocturnal plasma melatonin levels in patients with recurrent acute intermittent porphyria attacks. Life sciences, 1993, Volume: 53, Issue:8 Topics: Adult; Arginine; Circadian Rhythm; Female; Heme; Humans; Melatonin; Porphyria, Acute Intermittent; Recurrence; Tryptophan	1993
Early administration of heme arginate for acute porphyric attacks. Archives of internal medicine, 1993, Sep-13, Volume: 153, Issue:17 Topics: Adult; Aged; Arginine; Female; Heme; Humans; Length of Stay; Male; Middle Aged; Porphyria, Acute Intermittent; Time Factors; Treatment Outcome	1993
[Acute attacks of hepatic porphyria: specific treatment with heme arginate]. Annales de medecine interne, 1993, Volume: 144, Issue:3 Topics: Acute Disease; Arginine; Female; Heme; Hospitalization; Humans; Infusions, Intravenous; Male; Porphyrias, Hepatic; Time Factors	1993
Regulation of CYP 2 A 5 induction by porphyrinogenic agents in mouse primary hepatocytes. Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 355, Issue:1 Topics: Animals; Arginine; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Dactinomycin; Enzyme Induction; Griseofulvin; Heme; Liver; Male; Mice; Mice, Inbred DBA; Mixed Function Oxygenases; Nitrobenzoates; Phenobarbital; RNA, Messenger	1997
Stimulation of tetrapyrrole synthesis in mammalian epithelial cells in culture by exposure to aminolaevulinic acid. British journal of cancer, 1997, Volume: 75, Issue:3 Topics: Aminolevulinic Acid; Animals; Arginine; Biological Transport; Carbon Radioisotopes; Cattle; Cell Division; Cell Line; Cycloheximide; Dactinomycin; Epithelium; gamma-Aminobutyric Acid; Glutamic Acid; Heme; Kinetics; Leucine; Mammals; Pyrroles; Radioisotope Dilution Technique; Tetrapyrroles	1997
Acute porphyria: treatment with heme. Seminars in liver disease, 1998, Volume: 18, Issue:1 Topics: Acute Disease; Arginine; Heme; Hemin; Humans; Porphyrias, Hepatic	1998
5-Aminolevulinic acid dehydratase deficiency porphyria: a twenty-year clinical and biochemical follow-up. Clinical chemistry, 1998, Volume: 44, Issue:9 Topics: Adolescent; Aminolevulinic Acid; Arginine; Biomarkers; Erythrocytes; Follow-Up Studies; Glucose; Heme; Humans; Male; Mutation; Porphobilinogen Synthase; Porphyria, Acute Intermittent; Porphyrins	1998
Heme arginate therapy for beta thalassemia: in vitro versus in vivo effects. Acta haematologica, 1998, Volume: 100, Issue:2 Topics: Adult; Arginine; beta-Thalassemia; Cells, Cultured; Female; Heme; Humans; Infusions, Intravenous; Male; Treatment Outcome	1998
[Clinical manifestations and diagnosis of acute porphyria]. Terapevticheskii arkhiv, 1999, Volume: 71, Issue:7 Topics: Acute Disease; Adult; Arginine; Critical Care; Diagnosis, Differential; Female; Glucose; Heme; Humans; Infusions, Intravenous; Male; Middle Aged; Porphyrias; Pregnancy; Quality of Life; Respiration, Artificial	1999
Acute intermittent porphyria with central pontine myelinolysis and cortical laminar necrosis. Neuroradiology, 1999, Volume: 41, Issue:11 Topics: Adult; Arginine; Brain; Female; Fluid Therapy; Heme; Humans; Hyponatremia; Myelinolysis, Central Pontine; Necrosis; Porphyria, Acute Intermittent; Saline Solution, Hypertonic; Seizures; Vasospasm, Intracranial	1999
Ferriporphyrins and endothelium: a 2-edged sword-promotion of oxidation and induction of cytoprotectants. Blood, 2000, Jun-01, Volume: 95, Issue:11 Topics: Arginine; Cell Survival; Cells, Cultured; Deuteroporphyrins; Endothelium, Vascular; Ferric Compounds; Ferritins; Gene Expression Regulation; Heme; Heme Oxygenase (Decyclizing); Hemin; Humans; Hydrogen Peroxide; Lipoproteins, LDL; Neutrophils; Oxidation-Reduction; RNA, Messenger; Tetradecanoylphorbol Acetate; Thiobarbituric Acid Reactive Substances; Transcription, Genetic; Umbilical Veins	2000
Hereditary coproporphyria in Germany: clinical-biochemical studies in 53 patients. Clinical biochemistry, 2000, Volume: 33, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Arginine; Child; Chromatography, High Pressure Liquid; Coproporphyrinogen Oxidase; Coproporphyrins; Feces; Female; Germany; Heme; Heterozygote; Humans; Isomerism; Male; Middle Aged; Porphobilinogen; Porphyrias, Hepatic; Uroporphyrins	2000
Administration of heme arginate, but not hematin, caused anaphylactic shock. The American journal of medicine, 2001, Feb-15, Volume: 110, Issue:3 Topics: Adult; Anaphylaxis; Arginine; Female; Heme; Hemin; Humans; Porphyria, Acute Intermittent	2001
Zinc mesoporphyrin represses induced hepatic 5-aminolevulinic acid synthase and reduces heme oxygenase activity in a mouse model of acute hepatic porphyria. Hepatology (Baltimore, Md.), 2001, Volume: 33, Issue:5 Topics: 5-Aminolevulinate Synthetase; Acute Disease; Aminolevulinic Acid; Animals; Arginine; Cytosol; Drug Combinations; Female; Heme; Heme Oxygenase (Decyclizing); Injections, Intraperitoneal; Liver; Metalloporphyrins; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Phenobarbital; Porphyria, Acute Intermittent; Porphyrias, Hepatic; Reference Values; RNA, Messenger	2001
Haem arginate interferes with estimation of carcinoembryonic antigen. Annals of clinical biochemistry, 2001, Volume: 38, Issue:Pt 3 Topics: Adult; alpha-Fetoproteins; Arginine; Carcinoembryonic Antigen; Carcinoma, Hepatocellular; Chemistry, Clinical; Erythrocytes; False Positive Reactions; Female; Heme; Hemoglobins; Humans; Porphyrias, Hepatic; Prostate-Specific Antigen	2001
["Acute intermittent porphyria" diagnosis. An odyssey in diagnosis]. MMW Fortschritte der Medizin, 2002, May-23, Volume: 144, Issue:21 Topics: Abdominal Pain; Arginine; Colic; Diagnosis, Differential; Heme; Humans; Porphyria, Acute Intermittent	2002
A molecular, enzymatic and clinical study in a family with hereditary coproporphyria. Journal of inherited metabolic disease, 2002, Volume: 25, Issue:4 Topics: Adult; Aminolevulinic Acid; Arginine; Coproporphyrinogen Oxidase; DNA Mutational Analysis; Feces; Female; Heme; Humans; Porphyrias; Protein Denaturation	2002
Atypical attack of acute intermittent porphyria--paresis but no abdominal pain. Journal of internal medicine, 2002, Volume: 252, Issue:3 Topics: Abdominal Pain; Adult; Arginine; Disease Progression; Estradiol; Female; Heme; Humans; Hysterectomy; Middle Aged; Ovariectomy; Paresis; Periodicity; Porphyria, Acute Intermittent; Progesterone; Recurrence	2002
[Clinical manifestations of porphyrin metabolism disorders]. Terapevticheskii arkhiv, 2003, Volume: 75, Issue:7 Topics: Acute Disease; Adolescent; Adult; Arginine; Chronic Disease; Female; Heme; Humans; Inosine Diphosphate; Middle Aged; Octreotide; Plasmapheresis; Porphyria, Acute Intermittent; Porphyria, Erythropoietic; Porphyrias; Porphyrins	2003
Refractory status epilepticus due to acute hepatic porphyria in a pregnant woman: induced abortion as the sole therapeutic option? European journal of neurology, 2004, Volume: 11, Issue:10 Topics: Abortion, Induced; Adult; Arginine; Brain Mapping; Diffusion Magnetic Resonance Imaging; Electroencephalography; Female; Frontal Lobe; Heme; Humans; Porphyrias, Hepatic; Porphyrins; Pregnancy; Status Epilepticus; Time Factors	2004
Bilirubin from heme oxygenase-1 attenuates vascular endothelial activation and dysfunction. Arteriosclerosis, thrombosis, and vascular biology, 2005, Volume: 25, Issue:1 Topics: Animals; Aorta; Aorta, Thoracic; Arginine; Bilirubin; Endothelial Cells; Endothelium, Vascular; Enzyme Induction; Gene Expression Profiling; Gene Expression Regulation; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; In Vitro Techniques; Inflammation; Lipoproteins, LDL; Membrane Proteins; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oligonucleotide Array Sequence Analysis; Tumor Necrosis Factor-alpha; Vasodilation	2005
An analysis of 112 acute porphyric attacks in Cape Town, South Africa: Evidence that acute intermittent porphyria and variegate porphyria differ in susceptibility and severity. Medicine, 2005, Volume: 84, Issue:1 Topics: Abdominal Pain; Acute Disease; Adult; Age Factors; Arginine; Epidemiologic Methods; Female; Heme; Humans; Hypertension; Male; Porphyria, Acute Intermittent; Porphyria, Variegate; Precipitating Factors; Psychotic Disorders; Remission, Spontaneous; Sex Factors; South Africa; Tachycardia	2005
ED presentation of acute porphyria. The American journal of emergency medicine, 2005, Volume: 23, Issue:2 Topics: Abdominal Pain; Adolescent; Adult; Age of Onset; Analgesia; Arginine; Diagnostic Errors; Emergency Medicine; Emergency Service, Hospital; Female; Glucose; Heme; Humans; Hyponatremia; Infusions, Intravenous; Male; Middle Aged; Porphyria, Acute Intermittent; Retrospective Studies; Seizures; Taiwan; Treatment Outcome	2005
Prevention of hemorrhagic shock-induced lung injury by heme arginate treatment in rats. Biochemical pharmacology, 2005, Jun-01, Volume: 69, Issue:11 Topics: Animals; Arginine; Dose-Response Relationship, Drug; Heat-Shock Proteins; Heme; Heme Oxygenase (Decyclizing); Lung; Male; Oxygenases; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Shock, Hemorrhagic; Tumor Necrosis Factor-alpha	2005
Determination of carbon monoxide (CO) in rodent tissue: effect of heme administration and environmental CO exposure. Analytical biochemistry, 2005, Jun-15, Volume: 341, Issue:2 Topics: Animals; Arginine; Carbon Monoxide; Chromatography, Gas; Environmental Exposure; Heme; Male; Mice; Mice, Inbred BALB C; Rats; Rats, Wistar	2005
[Laboratory tests and therapeutic strategies for the porphyrias]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 2006, Volume: 57, Issue:6 Topics: Algorithms; Arginine; Critical Care; Diagnosis, Differential; Dose-Response Relationship, Drug; Drug Administration Schedule; Genetic Predisposition to Disease; Heme; Humans; Photosensitivity Disorders; Porphyria Cutanea Tarda; Porphyrias	2006
Treatment of an acute attack of porphyria during pregnancy. European journal of neurology, 2006, Volume: 13, Issue:6 Topics: Abortion, Induced; Arginine; Female; Heme; Humans; Porphyria, Acute Intermittent; Pregnancy; Pregnancy Complications, Infectious	2006
[Acute intermittent porphyria and oral contraception. Case report]. Ginekologia polska, 2006, Volume: 77, Issue:3 Topics: Adult; Arginine; Contraceptives, Oral, Synthetic; Desogestrel; Female; Glucose; Heme; Humans; Porphyria, Acute Intermittent; Saline Solution, Hypertonic; Treatment Outcome	2006
Heme arginate pretreatment attenuates pulmonary NF-kappaB and AP-1 activation induced by hemorrhagic shock via heme oxygenase-1 induction. Medicinal chemistry (Shariqah (United Arab Emirates)), 2006, Volume: 2, Issue:3 Topics: Animals; Arginine; Electrophoretic Mobility Shift Assay; Enzyme Induction; Heme; Heme Oxygenase (Decyclizing); Lung; Male; NF-kappa B; Rats; Shock, Hemorrhagic; Transcription Factor AP-1	2006
Ursodesoxycholic acid and heme-arginate are unable to improve hematopoiesis and liver injury in an erythropoietic protoporphyria mouse model. Physiological research, 2006, Volume: 55 Suppl 2 Topics: Animals; Arginine; Cholagogues and Choleretics; Disease Models, Animal; Hematopoiesis; Heme; Injections, Intraperitoneal; Liver; Mice; Mice, Transgenic; Protoporphyria, Erythropoietic; Ursodeoxycholic Acid	2006
[Management of pregnancy in women with acute porphyria. Case reports]. Terapevticheskii arkhiv, 2007, Volume: 79, Issue:8 Topics: Adult; Arginine; Female; Follow-Up Studies; Heme; Humans; Infant, Newborn; Male; Porphobilinogen; Porphyria, Acute Intermittent; Porphyrins; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Risk Factors	2007
[Favorable outcome of acute porphyric neuropathy after treatment with heme arginate]. Revue neurologique, 2007, Volume: 163, Issue:11 Topics: Adult; Arginine; Electrodiagnosis; Electrophysiology; Female; Heme; Humans; Laparoscopy; Motor Neuron Disease; Nervous System Diseases; Neural Conduction; Ovarian Cysts; Peripheral Nerves; Porphyria, Acute Intermittent; Postoperative Complications; Quadriplegia	2007
Hemin arginate-induced heme oxygenase 1 expression improves liver microcirculation and mediates an anti-inflammatory cytokine response after hemorrhagic shock. Shock (Augusta, Ga.), 2008, Volume: 29, Issue:5 Topics: Animals; Anti-Inflammatory Agents; Arginine; Cytokines; Heat-Shock Proteins; Heme; Heme Oxygenase-1; Hemorrhage; Interleukin-10; Liver; Male; Microcirculation; Rats; Rats, Sprague-Dawley; Shock, Hemorrhagic; Tumor Necrosis Factor-alpha	2008
Heme arginate suppresses cardiac lesions and hypertrophy in deoxycorticosterone acetate-salt hypertension. Experimental biology and medicine (Maywood, N.J.), 2009, Volume: 234, Issue:7 Topics: Animals; Arginine; Cardiomegaly; Desoxycorticosterone; Disease Models, Animal; Heart; Heart Diseases; Heme; Heme Oxygenase (Decyclizing); Hypertension; Hypertrophy, Left Ventricular; Male; MAP Kinase Kinase 4; Mesoporphyrins; Myocardium; NF-kappa B; Rats; Rats, Sprague-Dawley; Transcription Factor AP-1; Transforming Growth Factor beta	2009
The acute porphyrias: a diagnostic and therapeutic challenge in internal and emergency medicine. Internal and emergency medicine, 2009, Volume: 4, Issue:4 Topics: Arginine; Diagnostic Errors; Emergency Medicine; Heme; Humans; Internal Medicine; Porphyria, Acute Intermittent	2009
Safe and probably safe drugs in acute hepatic porphyria. Cellular and molecular biology (Noisy-le-Grand, France), 2009, Jul-01, Volume: 55, Issue:2 Topics: 5-Aminolevulinate Synthetase; Arginine; Drug-Related Side Effects and Adverse Reactions; Heme; Humans; Liver Transplantation; Porphyria, Acute Intermittent	2009
[Neurological complications of acute intermittent porphyria precipitated by porphyrinogenic drugs and efficiency of heme-arginate treatment]. La Tunisie medicale, 2009, Volume: 87, Issue:9 Topics: Acute Disease; Adolescent; Arginine; Electromyography; Famotidine; Female; Heme; Heme Oxygenase (Decyclizing); Humans; Nifedipine; Peripheral Nervous System Diseases; Phenobarbital; Porphyrias; Porphyrinogens; Time Factors	2009
Heme-arginate suppresses phospholipase C and oxidative stress in the mesenteric arterioles of mineralcorticoid-induced hypertensive rats. Hypertension research : official journal of the Japanese Society of Hypertension, 2010, Volume: 33, Issue:4 Topics: Animals; Arginine; Arterioles; Blood Pressure; Calcium; Cyclic GMP; Desoxycorticosterone; Dinoprost; Endothelin-1; Heme; Heme Oxygenase (Decyclizing); Hypertension; Inositol 1,4,5-Trisphosphate; Intracellular Fluid; Male; Mesenteric Arteries; Mineralocorticoids; NF-kappa B; Organometallic Compounds; Oxidative Stress; Rats; Rats, Sprague-Dawley; Second Messenger Systems; Sodium Chloride, Dietary; Type C Phospholipases; Up-Regulation	2010
Heme arginate therapy enhanced adiponectin and atrial natriuretic peptide, but abated endothelin-1 with attenuation of kidney histopathological lesions in mineralocorticoid-induced hypertension. The Journal of pharmacology and experimental therapeutics, 2010, Volume: 334, Issue:1 Topics: Adiponectin; Animals; Arginine; Atrial Natriuretic Factor; Blood Pressure; Blotting, Western; Desoxycorticosterone; Disease Models, Animal; Endothelin-1; Heme; Heme Oxygenase (Decyclizing); Hypertension; Kidney; Kidney Diseases; Male; Mineralocorticoids; Rats; Rats, Sprague-Dawley	2010
A retrospective analysis of outcome of pregnancy in patients with acute porphyria. Journal of inherited metabolic disease, 2010, Volume: 33, Issue:5 Topics: Abortion, Spontaneous; Adolescent; Adult; Arginine; Child; Female; Heme; Humans; Live Birth; London; Middle Aged; Porphyria, Acute Intermittent; Pregnancy; Pregnancy Complications; Retrospective Studies; Surveys and Questionnaires; Time Factors; Treatment Outcome; Young Adult	2010
The induction of macrophage hemeoxygenase-1 is protective during acute kidney injury in aging mice. Kidney international, 2011, Volume: 79, Issue:9 Topics: Acute Kidney Injury; Aging; Animals; Arginine; Cells, Cultured; Heme; Heme Oxygenase-1; Kidney; Macrophages; Membrane Proteins; Mice; Reperfusion Injury	2011
Haem arginate as effective maintenance therapy for hereditary coproporphyria. The Australasian journal of dermatology, 2011, Volume: 52, Issue:2 Topics: Abdominal Pain; Adult; Arginine; Coproporphyria, Hereditary; Female; Heme; Humans; Photosensitivity Disorders; Porphobilinogen; Severity of Illness Index; Treatment Outcome	2011
Heme arginate potentiates latent HIV-1 reactivation while inhibiting the acute infection. Antiviral research, 2011, Volume: 92, Issue:3 Topics: Acetylcysteine; Anti-HIV Agents; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Arginine; Cell Line; Heme; Heme Oxygenase-1; HIV-1; Humans; Jurkat Cells; Lectins, C-Type; Metalloporphyrins; Protoporphyrins; Proviruses; Reverse Transcription; Virus Activation; Virus Latency; Virus Replication	2011
Acute intermittent porphyria: fatal complications of treatment. Clinical medicine (London, England), 2012, Volume: 12, Issue:3 Topics: Abdominal Pain; Adolescent; Analgesics; Arginine; Disease Management; Fatal Outcome; Female; Hallucinations; Heme; Humans; Hyponatremia; Monitoring, Physiologic; Porphobilinogen; Porphyria, Acute Intermittent; Water-Electrolyte Balance	2012
Treatment with heme arginate alleviates adipose tissue inflammation and improves insulin sensitivity and glucose metabolism in a rat model of Human primary aldosteronism. Free radical biology & medicine, 2012, Dec-15, Volume: 53, Issue:12 Topics: Adiposity; Animals; Arginine; Chemokine CCL2; Disease Models, Animal; Endothelin-1; Enzyme Activators; Gene Expression; Glucose; Heme; Heme Oxygenase (Decyclizing); Humans; Hyperaldosteronism; Insulin; Insulin Resistance; Intercellular Adhesion Molecule-1; Intra-Abdominal Fat; JNK Mitogen-Activated Protein Kinases; Male; Mesoporphyrins; NF-kappa B; Oxidative Stress; Rats; Rats, Sprague-Dawley; Signal Transduction; Transcription Factor AP-1	2012
Paradoxical effects of heme arginate on survival of myocutaneous flaps. American journal of physiology. Regulatory, integrative and comparative physiology, 2014, Jan-01, Volume: 306, Issue:1 Topics: Animals; Arginine; Disease Models, Animal; Heme; Heme Oxygenase (Decyclizing); Myocutaneous Flap; Necrosis; Rats; Rats, Inbred Lew; Reperfusion Injury; Skin	2014
Administration of heme arginate ameliorates murine type 2 diabetes independently of heme oxygenase activity. PloS one, 2013, Volume: 8, Issue:10 Topics: 3T3 Cells; Adipocytes; Adipogenesis; Adiponectin; Adipose Tissue; Adiposity; Animals; Arginine; Blood Glucose; Cell Line; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Heme; Heme Oxygenase (Decyclizing); Hyperglycemia; Inflammation; Insulin-Secreting Cells; Metalloporphyrins; Mice; Pilot Projects	2013
Heme oxygenase suppresses markers of heart failure and ameliorates cardiomyopathy in L-NAME-induced hypertension. European journal of pharmacology, 2014, Jul-05, Volume: 734 Topics: Adiponectin; Aldosterone; Animals; Antioxidants; Arginine; Atrial Natriuretic Factor; Biomarkers; Blood Pressure; Cardiomyopathies; Cardiotonic Agents; Chemokine CCL2; Chemokine CCL3; Cyclic GMP; Dinoprost; Endothelin-1; Enzyme Induction; Extracellular Matrix Proteins; Heart Failure; Heme; Heme Oxygenase (Decyclizing); Hypertension; Interleukin-1beta; Interleukin-6; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Tyrosine	2014
Acute intermittent porphyria presenting as progressive muscular atrophy in a young black man. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2014, Volume: 104, Issue:4 Topics: Arginine; Heme; Humans; Hydroxymethylbilane Synthase; Male; Muscular Atrophy, Spinal; Porphyria, Acute Intermittent; Young Adult	2014
Chaperone therapy for homocystinuria: the rescue of CBS mutations by heme arginate. Journal of inherited metabolic disease, 2015, Volume: 38, Issue:2 Topics: Animals; Arginine; Catalytic Domain; CHO Cells; Cricetulus; Cystathionine beta-Synthase; Female; Fibroblasts; Genetic Predisposition to Disease; Heme; Homocystinuria; Homozygote; Humans; Models, Molecular; Molecular Chaperones; Mutation; Phenotype; Protein Conformation; Protein Folding; Proteostasis Deficiencies; Structure-Activity Relationship; Substrate Specificity; Transfection	2015
Heme Oxygenase Improves Renal Function by Potentiating Podocyte-Associated Proteins in Nω-Nitro-l-Arginine-Methyl Ester (l-NAME)-Induced Hypertension. American journal of hypertension, 2015, Volume: 28, Issue:7 Topics: Animals; Arginine; Biomarkers; Cytoprotection; Disease Models, Animal; Enzyme Induction; Enzyme Inhibitors; Extracellular Matrix Proteins; Fibrosis; Heme; Heme Oxygenase (Decyclizing); Hypertension; Inflammation Mediators; Kidney; Male; Mesoporphyrins; NG-Nitroarginine Methyl Ester; Oxidative Stress; Podocytes; Rats, Sprague-Dawley; Signal Transduction	2015
A 17-year-old girl with chronic intermittent abdominal pain. Acute intermittent porphyria. Pediatric annals, 2015, Volume: 44, Issue:4 Topics: Abdominal Pain; Adolescent; Arginine; Cholelithiasis; Chronic Disease; Diagnosis, Differential; Female; Heme; Humans; Porphyria, Acute Intermittent; Porphyrins; Tomography, X-Ray Computed	2015
Vascular and metabolic effects of the haem oxygenase-1 inducer haem arginate in subjects with the metabolic syndrome: A translational cross-over study. Diabetes & vascular disease research, 2016, Volume: 13, Issue:1 Topics: Acetylcholine; Adult; Aged; Arginine; Bilirubin; Cross-Over Studies; Endothelium, Vascular; Female; Ferritins; Glucose Clamp Technique; Heme; Heme Oxygenase-1; Humans; Insulin Resistance; Male; Metabolic Syndrome; Middle Aged; Nitroglycerin; Random Allocation; RNA, Messenger; Translational Research, Biomedical; Vasodilation; Vasodilator Agents	2016
Challenges in the successful management of a case of acute intermittent porphyria in India. Tropical doctor, 2016, Volume: 46, Issue:3 Topics: Abdominal Pain; Administration, Intravenous; Adolescent; Arginine; Heme; Humans; India; Male; Porphobilinogen; Porphyria, Acute Intermittent; Seizures; Treatment Outcome	2016
Acute Intermittent Porphyria Presenting with Posterior Reversible Encephalopathy Syndrome, Accompanied by Prolonged Vasoconstriction. Internal medicine (Tokyo, Japan), 2017, Volume: 56, Issue:6 Topics: Arginine; Female; Heme; Humans; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Porphyria, Acute Intermittent; Posterior Leukoencephalopathy Syndrome; Young Adult	2017
Dysregulation of homocysteine homeostasis in acute intermittent porphyria patients receiving heme arginate or givosiran. Journal of inherited metabolic disease, 2021, Volume: 44, Issue:4 Topics: Acetylgalactosamine; Adult; Arginine; Cystathionine beta-Synthase; Female; Folic Acid; Heme; Homeostasis; Homocysteine; Homocystinuria; Humans; Hydroxymethylbilane Synthase; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Porphyria, Acute Intermittent; Pyridoxal Phosphate; Pyrrolidines; Young Adult	2021
Severe homocysteinemia in two givosiran-treated porphyria patients: is free heme deficiency the culprit? Annals of hematology, 2021, Volume: 100, Issue:7 Topics: 5-Aminolevulinate Synthetase; Acetylgalactosamine; Adult; Arginine; Colitis; Colon, Sigmoid; Controlled Clinical Trials as Topic; Drug Hypersensitivity; Female; Fibrosis; Heme; Hepatocytes; High-Throughput Nucleotide Sequencing; Homocysteine; Humans; Hydroxymethylbilane Synthase; Hyperhomocysteinemia; Male; Models, Biological; Pancreatitis; Porphyria, Acute Intermittent; Pyrrolidines	2021
Safety of haem arginate in overdose: report of an uneventful fourfold accidental overdose. Clinical toxicology (Philadelphia, Pa.), 2022, Volume: 60, Issue:3 Topics: Arginine; Drug Overdose; Heme; Humans	2022