arginine has been researched along with guanosine triphosphate in 102 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 22 (21.57) | 18.7374 |
1990's | 26 (25.49) | 18.2507 |
2000's | 38 (37.25) | 29.6817 |
2010's | 12 (11.76) | 24.3611 |
2020's | 4 (3.92) | 2.80 |
Authors | Studies |
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Colman, RF; Pal, PK | 1 |
Izui, K; Kameshita, I; Katsuki, H; Tokushige, M | 1 |
Heizmann, P; Howell, SH | 1 |
Rochovansky, O | 1 |
Laustiola, KE; Manninen, V; Metsä-Ketelä, T; Pörsti, I; Vapaatalo, H; Vuorinen, P | 1 |
Deguchi, T; Fujimori, H; Inamura, K; Ishikawa, F; Kosasayama, A; Masayasu, H; Suzuki, K; Yoshioka, M | 1 |
Christian, E; Illangesekare, M; Yarus, M | 1 |
Dong, Q; Fromm, HJ; Liu, F; Myers, AM | 1 |
Christian, EL; Hicke, BJ; Yarus, M | 1 |
Freissmuth, M; Gilman, AG | 1 |
Yarus, M | 2 |
Cech, TR; Levine, J; Morin, GB; Yarus, M | 1 |
Federn, H; Ristow, H | 1 |
Fujiwara, M; Kamiya, T; Narumiya, S; Ohashi, Y | 1 |
Howell, SL; Montague, W | 1 |
Birnbaumer, L; Yang, PC | 1 |
Birnbaumer, L; Nakahara, T; Yang, PC | 1 |
Ofengand, J | 1 |
Gallant, J; Margason, G | 1 |
Barrett, J | 1 |
Kaji, H; Tanaka, Y | 1 |
Blethen, SL | 1 |
Carta, F; Maraini, G; Pescatori, A; Prosperi, L | 1 |
Kassab, R; Pradel, LA; Roustan, C; Van Thoai, N | 1 |
de Nó, C; Hernández, F; Palacián, E | 1 |
Berghuis, AM; Coleman, DE; Gilman, AG; Lee, E; Linder, ME; Sprang, SR | 1 |
Lee, YH; Lin, K; Okar, D; Pilkis, SJ | 1 |
Brownbridge, GG; Lowe, PN; Moore, KJ; Skinner, RH; Webb, MR | 1 |
Rikkonen, M | 1 |
Demeure, MJ; Doffek, KM; Gorski, J; Komorowski, RA | 1 |
Clark, BF; Knudsen, CR | 1 |
Bourne, HR; Farfel, Z; Iiri, T | 1 |
Amin, RH; Bondarenko, VA; Desai, M; Dua, S; Hayashi, F; Jackson, KW; Kinumi, T; Komori, N; Lipkin, VM; Matsumoto, H; Ohashi, M; Usukura, J; Yamazaki, A; Yamazaki, M; Yousif, KK | 1 |
Eccleston, JF; Gamblin, SJ; Laue, E; Nurmahomed, K; Owen, D; Rittinger, K; Smerdon, SJ; Walker, PA | 1 |
Ehrenfeld, E; Richards, OC | 1 |
Ahmadian, MR; Scheffzek, K; Stege, P; Wittinghofer, A | 1 |
Bourne, HR | 1 |
Clark, BF; Knudsen, CR; Nautrup Pedersen, G; Rattenborg, T | 1 |
Eccleston, JF; Graham, DL; Lowe, PN | 1 |
Moss, J; Vaughan, M; Vitale, N | 1 |
Gamblin, SJ; Rittinger, K; Smerdon, SJ; Taylor, WR | 1 |
Daniel, DS; Dickey, BF; Hoffenberg, S; Nichols, JC; Nikolova, L; Soman, K | 1 |
Goldberg, J | 1 |
Kemp, RG; Wang, X | 1 |
Barbieri, JT; Ganesan, AK; Olson, JC; Vincent, TS | 1 |
Koyama, T; Nakagawa, S; Nishi, N; Odagaki, Y | 1 |
Mohr, D; Rodnina, MV; Savelsbergh, A; Wilden, B; Wintermeyer, W | 1 |
Tabancay, AP; Tamanoi, F; Urano, J; Yang, W | 1 |
Cassel, D; Huber, I; Pick, E; Rotman, M; Szafer, E; Zuck, S | 1 |
Clabecq, A; Darchen, F; Henry, JP | 1 |
Mohr, D; Rodnina, MV; Wintermeyer, W | 1 |
Brannetti, B; Ferrè, F; Helmer-Citterich, M; Valencia, A; Via, A | 1 |
Bienengraeber, M; Echtay, KS; Klingenberg, M | 1 |
Dixon, DA; Miller, JH; Resat, H; Straatsma, TP | 1 |
Daitoku, H; Fujiwara, K; Fukamizu, A; Isida, J; Nakajima, T | 1 |
Chen, C; Chou, CC; Forouhar, F; Hsiao, CD; Kao, S; Li Hm, HM; Shr, HL; Sun, YJ; Tu, SL; Yeh, YH | 1 |
Körner, C; Seewald, MJ; Vetter, IR; Wittinghofer, A | 1 |
Banchelli, G; Matucci, R; Pirisino, R; Raimondi, L; Stillitano, F | 1 |
Karpusas, M; Plaitakis, A; Spanaki, C; Zaganas, I | 1 |
Cerione, RA; Fidyk, NJ | 1 |
Willemoës, M | 1 |
Bearne, SL; Hewitt, KA; Iyengar, A; Lunn, F; Simard, D | 1 |
Downs, MA; Hargrave, PA; Kisselev, OG; McDowell, JH | 1 |
Bunster, M; Hinrichs, MV; Montecino, M; Olate, J | 1 |
Ashikaga, T; Kishi, Y; Numano, F; Watanabe, R | 1 |
Arnold, E; Ding, J; Guan, K; Li, S; Li, Y; Xu, X; Yu, Y | 1 |
Armengod, ME; Björk, GR; Martínez-Vicente, M; Mellado, M; Pérez-Payá, E; Villarroya, M; Yim, L | 1 |
Iguchi, N; Isotani, A; Kitamura, K; Maekawa, M; Masai, K; Matsuoka, Y; Nishimune, Y; Okabe, M; Onishi, M; Tanaka, H; Toshimori, K; Toyama, Y | 1 |
Cerione, RA; Pereira, R | 1 |
Brack-Werner, R; Devaux, C; Fridkin, G; Gilon, C; Hariton-Gazal, E; Loyter, A; Rosenbluh, J; Wolff, H; Zakai, N | 1 |
Becker, A; Eschenburg, S; Kull, FJ; Leonard, M; Manstein, DJ; Reubold, TF; Schmid, SL; Vallee, RB | 1 |
Cerione, RA; Majumdar, S; Ramachandran, S | 1 |
Brownie, ER; Fraser, ME; Hayakawa, K; Hume, MS; Ryan, DG | 1 |
Ghosh, A; Herrmann, C; Praefcke, GJ; Renault, L; Wittinghofer, A | 1 |
Begg, GE; Graham, RM; Holman, SR; Iismaa, SE; Matthews, JM; Stokes, PH | 1 |
Begg, GE; Carrington, L; Graham, RM; Husain, A; Iismaa, SE; Lorand, L; Matthews, JM; Stokes, PH; Wouters, MA | 1 |
Bange, G; Parlitz, RO; Petzold, G; Sinning, I; Wild, K | 1 |
Gerwert, K; Schlitter, J; te Heesen, H | 1 |
Deaconescu, D; Scrima, A; Thomas, C; Wittinghofer, A | 1 |
Marco-Marín, C; Rubio, V | 1 |
Beauchamp, BB; Crampton, DJ; Richardson, CC; Satapathy, AK | 1 |
Du, X; Sprang, SR | 1 |
Lushington, GH; Mou, TC; Pinto, C; Richter, M; Seifert, R; Suryanarayana, S | 1 |
Chou, KC; Wang, JF | 1 |
Haber, M; Iismaa, SE; Liu, PY; Liu, T; Marshall, GM; Norris, MD; Tee, AEL; Xu, N | 1 |
Farquhar, MG; Garcia-Marcos, M; Ghosh, P | 1 |
Hot, E; Keilberg, D; Koerner, C; Leonardy, S; Miertzschke, M; Søgaard-Andersen, L; Vetter, IR; Wittinghofer, A | 1 |
Herrmann, C; Kunzelmann, S; Wehner, M | 1 |
Kotsiuruba, AV; Moĭbenko, OO; Neshcheret, OP; Rovenets', RA; Strutyns'kyĭ, RB | 1 |
Anand, B; Majumdar, S; Prakash, B | 1 |
Jeganathan, A; Ortega, J; Razi, A; Thurlow, B | 1 |
Jang, H; Lu, S; Nussinov, R; Zhang, J | 1 |
Feng, W; Kong, R; Lou, J; Ren, J; Wu, JY; Yi, F; Zhu, L | 1 |
Acharya, A; Majumdar, S; Prakash, B | 1 |
Chandra, M; Datta, S; Kotyada, C; Narooka, AR; Tripathi, A; Verma, A | 1 |
Gu, X; Sabatini, DM; Shen, K; Valenstein, ML | 1 |
Garcia, AE; Ngo, VA | 1 |
Gong, P; Jia, H; Peng, C; Zhong, Y | 1 |
Neale, C; Patel, LA; Stephen, AG; Waybright, TJ | 1 |
Bazer, FW; Burghardt, RC; Johnson, GA; Li, X; Wu, G | 1 |
Bergman, AM; Jensen, PB; Munch-Petersen, B; Peters, GJ; Pinedo, HM; Sehested, M; Smid, K; Veerman, G; Voorn, DA | 1 |
102 other study(ies) available for arginine and guanosine triphosphate
Article | Year |
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The importance of arginine residues in the catalytic and regulatory functions of bovine-liver glutamate dehydrogenase.
Topics: Adenosine Diphosphate; Allosteric Regulation; Allosteric Site; Arginine; Butanones; Glutamate Dehydrogenase; Guanosine Triphosphate; Kinetics; Liver; NAD; Protein Binding | 1976 |
Reversible desensitization of phosphoenolpyruvate carboxylase to multiple effectors by butanedione.
Topics: Acetyl Coenzyme A; Allosteric Site; Arginine; Aspartic Acid; Binding Sites; Borates; Butanones; Diacetyl; Escherichia coli; Guanosine Triphosphate; Kinetics; Lactates; Lauric Acids; Magnesium; Phosphoenolpyruvate Carboxykinase (GTP) | 1977 |
Synthesis of ppGpp and chloroplast ribosomal RNA in Chlamydomonas reinhardi.
Topics: Arginine; Chlamydomonas; Chloroplasts; Cycloheximide; Cytoplasm; Guanine Nucleotides; Guanosine Tetraphosphate; Guanosine Triphosphate; Mutation; RNA, Ribosomal | 1978 |
On the role of substrate and GTP in the regulation of argininosuccinase activity.
Topics: Animals; Arginine; Argininosuccinate Lyase; Argininosuccinic Acid; Binding Sites; Cattle; Guanosine Triphosphate; Kinetics; Liver; Lyases; Macromolecular Substances; Molecular Weight; Osmolar Concentration; Phosphates; Protein Binding; Tromethamine | 1975 |
Endothelium-dependent and -independent effects of exogenous ATP, adenosine, GTP and guanosine on vascular tone and cyclic nucleotide accumulation of rat mesenteric artery.
Topics: Acetylcholine; Adenosine; Adenosine Triphosphate; Animals; Arginine; Cyclic AMP; Cyclic GMP; Endothelium, Vascular; Guanosine; Guanosine Triphosphate; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Relaxation; Muscle Tonus; Muscle, Smooth, Vascular; Nitroarginine; Nucleotides; Rats; Rats, Inbred Strains | 1992 |
Effects of arginine derivatives on soluble guanylate cyclase from neuroblastoma N1E 115 cells.
Topics: Arginine; Binding, Competitive; Dansyl Compounds; Guanosine Triphosphate; Guanylate Cyclase; Magnesium; Molecular Structure; Neuroblastoma; Structure-Activity Relationship; Tumor Cells, Cultured | 1990 |
Selection of small molecules by the Tetrahymena catalytic center.
Topics: Amino Acids; Animals; Arginine; Base Sequence; Catalysis; Chromatography, Liquid; Guanosine Triphosphate; Models, Molecular; Molecular Sequence Data; Nucleic Acid Conformation; RNA Splicing; RNA, Protozoan; Substrate Specificity; Tetrahymena | 1991 |
Evidence for an arginine residue at the substrate binding site of Escherichia coli adenylosuccinate synthetase as studied by chemical modification and site-directed mutagenesis.
Topics: Adenylosuccinate Synthase; Amino Acid Sequence; Arginine; Base Sequence; Binding Sites; Chromatography, High Pressure Liquid; Escherichia coli; Guanosine Triphosphate; Inosine Monophosphate; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Mapping; Phenylglyoxal; Trypsin | 1991 |
Stereoselective arginine binding is a phylogenetically conserved property of group I self-splicing RNAs.
Topics: Amino Acids; Ammonium Chloride; Arginine; Base Sequence; Binding, Competitive; Guanosine Triphosphate; Introns; Kinetics; Molecular Sequence Data; Neurospora; Neurospora crassa; Nucleic Acid Conformation; Osmolar Concentration; Phylogeny; RNA Splicing; RNA, Catalytic; RNA, Fungal; RNA, Ribosomal; Stereoisomerism | 1989 |
Mutations of GS alpha designed to alter the reactivity of the protein with bacterial toxins. Substitutions at ARG187 result in loss of GTPase activity.
Topics: Adenylate Cyclase Toxin; Animals; Arginine; Binding Sites; Cholera Toxin; DNA; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Kinetics; Mutation; NAD; Pertussis Toxin; Phosphoric Monoester Hydrolases; Protein Binding; Recombinant Proteins; Restriction Mapping; Thionucleotides; Virulence Factors, Bordetella | 1989 |
Specificity of arginine binding by the Tetrahymena intron.
Topics: Animals; Arginine; Binding, Competitive; Guanosine Triphosphate; Introns; Kinetics; Models, Molecular; RNA Precursors; RNA Splicing; RNA, Catalytic; RNA, Ribosomal; Structure-Activity Relationship; Tetrahymena; Transcription, Genetic | 1989 |
A Tetrahymena intron nucleotide connected to the GTP/arginine site.
Topics: Animals; Arginine; Base Sequence; Binding Sites; Guanosine Triphosphate; Introns; Molecular Sequence Data; Nucleic Acid Conformation; RNA Precursors; RNA Splicing; RNA, Catalytic; RNA, Ribosomal; Tetrahymena | 1989 |
The GTP pool in Bacillus brevis and its significance for sporulation.
Topics: Adenine Nucleotides; Arginine; Bacillus; Energy Metabolism; Guanine Nucleotides; Guanosine Triphosphate; Kinetics; Spores, Bacterial; Threonine; Tyrocidine | 1987 |
A specific amino acid binding site composed of RNA.
Topics: Animals; Arginine; Binding Sites; Catalysis; Genetic Code; Guanosine Triphosphate; Kinetics; Magnesium; Models, Molecular; RNA Splicing; RNA, Ribosomal; Structure-Activity Relationship; Tetrahymena | 1988 |
ADP-ribosylation by type C1 and D botulinum neurotoxins: stimulation by guanine nucleotides and inhibition by guanidino-containing compounds.
Topics: Adenosine Diphosphate Ribose; Agmatine; Animals; Arginine; Botulinum Toxins; Brain; Guanidines; Guanine Nucleotides; Guanosine Diphosphate; Guanosine Triphosphate; Mice; Molecular Weight; Toxoids | 1987 |
Adenylate cyclase activity in isolated rat islets of Langerhans. Effects of agents which alter rates of insulin secretion.
Topics: Adenylyl Cyclases; Animals; Arginine; Epinephrine; Fluorides; Glucagon; Glucose; Glyburide; Guanosine Triphosphate; Hydrogen-Ion Concentration; In Vitro Techniques; Islets of Langerhans; Isoproterenol; Kinetics; Leucine; Male; Norepinephrine; Nucleotides; Phenoxybenzamine; Phosphorus Radioisotopes; Potassium; Propranolol; Prostaglandins; Rats; Xylitol | 1973 |
Studies on receptor-mediated activation of adenylyl cyclases. I. Preparation and description of general properties of an adenylyl cyclase system in beef renal medullary membranes sensitive to neurohypophyseal hormones.
Topics: Adenylyl Cyclases; Animals; Arginine; Cattle; Cell Membrane; Centrifugation, Density Gradient; Chromatography, Ion Exchange; Chromatography, Thin Layer; Cyclic AMP; Enzyme Activation; Guanosine Triphosphate; Kidney; Kidney Medulla; Kinetics; Lysine; Microscopy, Phase-Contrast; Oxytocin; Phosphorus Radioisotopes; Receptors, Cell Surface; Subcellular Fractions; Time Factors; Tritium; Vasopressins | 1974 |
Studies on receptor-mediated activation of adenylyl cyclases. II. Nucleotide and nucleoside regulation of the activities of the beef renal medullary adenylyl cyclase and their stimulation by neurohypophyseal hormones.
Topics: Adenosine; Adenosine Monophosphate; Adenosine Triphosphate; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Allosteric Regulation; Animals; Arginine; Cattle; Cell Membrane; Enzyme Activation; Guanosine Triphosphate; Hydrogen-Ion Concentration; Kidney; Kidney Medulla; Kinetics; Manganese; Oxytocin; Phosphorus Radioisotopes; Pituitary Hormones, Posterior; Receptors, Cell Surface; Ribonucleotides; Time Factors; Vasopressins | 1974 |
Assay for AA-tRNA recognition by the EFTu-GTP complex of Escherichia coli.
Topics: Amino Acids; Arginine; Binding Sites; Binding, Competitive; Escherichia coli; Evaluation Studies as Topic; Fluorouracil; Guanosine Triphosphate; Kinetics; Methionine; Methods; Peptide Elongation Factors; Phenylalanine; Protein Binding; RNA, Bacterial; RNA, Transfer; Time Factors; Tryptophan; Valine | 1974 |
Amino acid control of messenger ribonucleic acid synthesis in Bacillus subtilis.
Topics: Adenine; Adenosine Triphosphate; Amino Acids; Arginine; Bacillus subtilis; Chromatography, Thin Layer; Culture Media; Genetics, Microbial; Guanine Nucleotides; Guanosine Triphosphate; Mutation; Phosphoric Acids; Phosphorus Isotopes; RNA, Bacterial; RNA, Messenger; Tritium | 1972 |
Nucleoside triphosphate metabolism in the muscle tissue of Ascaris lumbricoides (Nematoda).
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Aminohydrolases; Animals; Arginine; Ascaris; Chromatography, Thin Layer; Creatine; Creatine Kinase; Female; Guanine Nucleotides; Guanosine Triphosphate; Inosine Nucleotides; Muscles; Phosphates; Phosphotransferases; Ribonucleotides; Swine; Uridine Diphosphate Sugars | 1973 |
Incorporation of arginine by soluble extracts of ascites tumor cells and regenerating rat liver.
Topics: Adenosine Triphosphate; Amino Acyl-tRNA Synthetases; Animals; Arginine; Carbon Radioisotopes; Carcinoma, Ehrlich Tumor; Cell-Free System; Centrifugation, Density Gradient; Guanosine Triphosphate; Hepatectomy; Liver; Liver Regeneration; Neoplasm Proteins; Puromycin; Rats; Ribonucleases; Ribosomes; RNA, Transfer; Time Factors | 1974 |
Kinetic properties of the arginine kinase isoenzymes of Limulus polyphemus.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Arginine; Brachyura; Calcium; Canavanine; Carbon Isotopes; Chromatography, Thin Layer; Enzyme Activation; Guanidines; Guanosine Triphosphate; Inosine Nucleotides; Isoenzymes; Kinetics; Magnesium; Manganese; Models, Chemical; Phosphotransferases; Stereoisomerism; Structure-Activity Relationship; Valerates | 1972 |
Protein metabolism in human senile cataract.
Topics: Adenosine Triphosphate; Aged; Amino Acids; Animals; Arginine; Aspartic Acid; Biological Transport; Cataract; Crystallins; Guanosine Triphosphate; Humans; Lens, Crystalline; Leucine; Rabbits; Tritium | 1971 |
Studies on the partial exchange and overall reactions catalyzed by native and modified arginine kinase from Homarus vulgaris muscle.
Topics: Adenine Nucleotides; Alkylation; Animals; Annelida; Arginine; Binding Sites; Carbon Isotopes; Catalysis; Chemical Phenomena; Chemistry; Chromatography, Paper; Creatine Kinase; Cysteine; Dansyl Compounds; Guanosine Triphosphate; Histidine; Kinetics; L-Lactate Dehydrogenase; Lysine; Muscles; Nephropidae; Phosphotransferases; Protein Binding; Pyruvate Kinase; Rabbits | 1971 |
Functional implication of the sole arginine residue of ribosomal proteins L7/L12.
Topics: Amino Acid Sequence; Arginine; Bacterial Proteins; Escherichia coli; Guanosine Diphosphate; Guanosine Triphosphate; Peptide Biosynthesis; Peptides; Ribosomal Proteins | 1984 |
Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis.
Topics: Aluminum Compounds; Arginine; Binding Sites; Catalysis; Computer Graphics; Crystallography, X-Ray; Fluorides; Glutamine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Helix-Loop-Helix Motifs; Hydrogen Bonding; Hydrolysis; Models, Molecular; Protein Conformation; Protein Structure, Secondary | 1994 |
Mechanism of modulation of rat liver fructose-2,6-bisphosphatase by nucleoside triphosphates.
Topics: Adenosine Triphosphate; Alanine; Amino Acid Sequence; Animals; Arginine; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Guanosine Triphosphate; Kinetics; Liver; Lysine; Molecular Weight; Mutagenesis, Site-Directed; Phosphofructokinase-2; Phosphoric Monoester Hydrolases; Point Mutation; Rats; Recombinant Proteins; Sequence Deletion | 1994 |
Interaction of GTPase activating proteins (GAPs) with p21ras measured by a novel fluorescence anisotropy method. Essential role of Arg-903 of GAP in activation of GTP hydrolysis on p21ras.
Topics: Amino Acid Sequence; Arginine; Escherichia coli; Fluorescence Polarization; GTPase-Activating Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Kinetics; Macromolecular Substances; Mathematics; Models, Biological; Mutagenesis, Site-Directed; Proteins; Proto-Oncogene Proteins p21(ras); ras GTPase-Activating Proteins; Recombinant Proteins | 1993 |
Functional significance of the nuclear-targeting and NTP-binding motifs of Semliki Forest virus nonstructural protein nsP2.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Arginine; Base Sequence; Binding Sites; Cell Line; Cell Nucleus; Cricetinae; Cytoplasm; DNA; Female; Guanosine Triphosphate; Lysine; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Mutation; Protein Biosynthesis; Semliki forest virus; Viral Nonstructural Proteins; Virus Replication | 1996 |
Gip-2 codon 179 oncogene mutations: absent in adrenal cortical tumors.
Topics: Adenoma; Adrenal Cortex Neoplasms; Arginine; Base Sequence; Carcinoma; Codon; Cysteine; DNA Restriction Enzymes; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Proteins; Guanosine Triphosphate; Histidine; Humans; Molecular Sequence Data; Oncogenes; Point Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length | 1996 |
Site-directed mutagenesis of Arg58 and Asp86 of elongation factor Tu from Escherichia coli: effects on the GTPase reaction and aminoacyl-tRNA binding.
Topics: Anti-Bacterial Agents; Arginine; Aspartic Acid; Base Sequence; DNA Primers; Escherichia coli; GTP Phosphohydrolase-Linked Elongation Factors; Guanosine Diphosphate; Guanosine Triphosphate; Kinetics; Models, Molecular; Molecular Sequence Data; Molecular Structure; Mutagenesis, Site-Directed; Peptide Elongation Factor Tu; Protein Binding; Pyridones; Recombinant Proteins; Ribosomes; RNA, Transfer; RNA, Transfer, Phe | 1995 |
Conditional activation defect of a human Gsalpha mutant.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Arginine; Cell Line; Conserved Sequence; Cyclic AMP; Glutamic Acid; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Humans; Isoproterenol; Kinetics; Macromolecular Substances; Models, Molecular; Mutagenesis, Site-Directed; Point Mutation; Protein Conformation; Receptors, Adrenergic, beta-2; Recombinant Fusion Proteins; Spodoptera; Transfection | 1997 |
Residues within the polycationic region of cGMP phosphodiesterase gamma subunit crucial for the interaction with transducin alpha subunit. Identification by endogenous ADP-ribosylation and site-directed mutagenesis.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adenosine Diphosphate Ribose; Animals; Arginine; Binding Sites; Cattle; Cyclic Nucleotide Phosphodiesterases, Type 6; GTP Phosphohydrolases; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Mutagenesis, Site-Directed; NAD; Pertussis Toxin; Rana catesbeiana; Recombinant Proteins; Transducin; Virulence Factors, Bordetella | 1997 |
Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP.
Topics: Arginine; cdc42 GTP-Binding Protein; Cell Cycle Proteins; Crystallography, X-Ray; Enzyme Activation; GTP Phosphohydrolases; GTP-Binding Proteins; GTPase-Activating Proteins; Guanosine Triphosphate; Models, Molecular; Protein Conformation | 1997 |
One of two NTP binding sites in poliovirus RNA polymerase required for RNA replication.
Topics: Arginine; Binding Sites; Borohydrides; Cross-Linking Reagents; Cyanogen Bromide; Guanosine Triphosphate; Leucine; Lysine; Nucleotides; Peptide Fragments; Poliovirus; RNA-Dependent RNA Polymerase; RNA, Viral | 1997 |
Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras.
Topics: Arginine; Binding Sites; GTP Phosphohydrolases; GTPase-Activating Proteins; Guanosine Triphosphate; Proteins; ras GTPase-Activating Proteins; ras Proteins | 1997 |
G proteins. The arginine finger strikes again.
Topics: Arginine; GTP Phosphohydrolases; GTP-Binding Proteins; GTPase-Activating Proteins; Guanosine Triphosphate; Hydrolysis; Protein Binding; Protein Conformation; Proteins; RGS Proteins; rhoA GTP-Binding Protein; Signal Transduction | 1997 |
Contribution of Arg288 of Escherichia coli elongation factor Tu to translational functionality.
Topics: Amino Acid Sequence; Amino Acid Substitution; Arginine; Asparagine; Binding Sites; Conserved Sequence; Escherichia coli; GTP Phosphohydrolase-Linked Elongation Factors; Guanosine Diphosphate; Guanosine Triphosphate; Hydrogen Bonding; Kinetics; Lysine; Models, Molecular; Mutagenesis, Site-Directed; Peptide Elongation Factor Tu; Protein Conformation; Recombinant Proteins; Ribosomes; RNA, Transfer, Phe; Thermus | 1997 |
Characterisation of the interaction of normal and mutant Rho-GAP with Rho family proteins.
Topics: Amino Acid Sequence; Arginine; Conserved Sequence; GTP Phosphohydrolases; GTP-Binding Proteins; GTPase-Activating Proteins; Guanosine Triphosphate; Kinetics; Mutagenesis, Site-Directed; Proteins; rac GTP-Binding Proteins; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid | 1997 |
Molecular characterization of the GTPase-activating domain of ADP-ribosylation factor domain protein 1 (ARD1).
Topics: Arginine; DNA Mutational Analysis; GTP Phosphohydrolases; GTP-Binding Proteins; GTPase-Activating Proteins; Guanosine Triphosphate; Hydrolysis; Protein Binding; Proteins; Recombinant Fusion Proteins; Zinc Fingers | 1998 |
Support for shared ancestry of GAPs.
Topics: Arginine; Binding Sites; Evolution, Molecular; GTPase-Activating Proteins; Guanosine Triphosphate; Protein Conformation; Proteins; ras GTPase-Activating Proteins; ras Proteins; Signal Transduction | 1998 |
Conformationally variable Rab protein surface regions mapped by limited proteolysis and homology modelling.
Topics: Amino Acid Sequence; Arginine; Binding Sites; Conserved Sequence; GTP-Binding Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Mass Spectrometry; Models, Molecular; Molecular Sequence Data; Protein Conformation; rab4 GTP-Binding Proteins; rab5 GTP-Binding Proteins; Sequence Analysis; Sequence Homology, Amino Acid; Trypsin | 1998 |
Structural and functional analysis of the ARF1-ARFGAP complex reveals a role for coatomer in GTP hydrolysis.
Topics: ADP-Ribosylation Factor 1; ADP-Ribosylation Factors; Amino Acid Sequence; Animals; Arginine; Coatomer Protein; GTP Phosphohydrolases; GTP-Binding Proteins; GTPase-Activating Proteins; Guanosine Triphosphate; Humans; Hydrolysis; Membrane Proteins; Molecular Sequence Data; Protein Conformation; Proteins; ras GTPase-Activating Proteins; ras Proteins; Rats; Sequence Homology, Amino Acid; Structure-Activity Relationship | 1999 |
Identification of residues of Escherichia coli phosphofructokinase that contribute to nucleotide binding and specificity.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Amino Acids; Arginine; Binding Sites; Cytidine Triphosphate; Escherichia coli; Guanosine Triphosphate; Inosine Triphosphate; Models, Molecular; Mutagenesis, Site-Directed; Phenylalanine; Phosphofructokinase-1; Substrate Specificity; Tyrosine; Uridine Triphosphate | 1999 |
Pseudomonas aeruginosa exoenzyme S disrupts Ras-mediated signal transduction by inhibiting guanine nucleotide exchange factor-catalyzed nucleotide exchange.
Topics: Adenosine Diphosphate; Adenosine Diphosphate Ribose; ADP Ribose Transferases; Animals; Arginine; Bacterial Toxins; Cell Cycle Proteins; Cell Line; Coculture Techniques; Guanosine Triphosphate; Kinetics; Mammals; Pseudomonas aeruginosa; ras Proteins; ras-GRF1; Recombinant Fusion Proteins; Signal Transduction; Transfection | 1999 |
Activation of G proteins by neuropeptide Y and gamma-aminobutyric acid(B) receptor agonists in rat cerebral cortical membranes through distinct modes of action.
Topics: Animals; Arginine; Biotransformation; Cell Membrane; Cerebral Cortex; GABA-B Receptor Agonists; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine Triphosphate; Magnesium Chloride; Male; Neuropeptide Y; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; Stimulation, Chemical | 1999 |
Stimulation of the GTPase activity of translation elongation factor G by ribosomal protein L7/12.
Topics: Amino Acid Substitution; Arginine; GTP Phosphohydrolases; Guanosine Triphosphate; Kinetics; Methionine; Mutagenesis, Site-Directed; Peptide Elongation Factor G; Recombinant Proteins; Ribosomal Proteins; RNA, Transfer, Phe | 2000 |
The Saccharomyces cerevisiae Rheb G-protein is involved in regulating canavanine resistance and arginine uptake.
Topics: Amino Acid Sequence; Amino Acid Transport Systems; Arginine; Canavanine; Cysteine; Drosophila Proteins; Fungal Proteins; Guanosine Triphosphate; Humans; Membrane Transport Proteins; Molecular Sequence Data; Monomeric GTP-Binding Proteins; Neuropeptides; Protein Prenylation; Ras Homolog Enriched in Brain Protein; Saccharomyces cerevisiae; Schizosaccharomyces pombe Proteins; Structure-Activity Relationship | 2000 |
Role of coatomer and phospholipids in GTPase-activating protein-dependent hydrolysis of GTP by ADP-ribosylation factor-1.
Topics: ADP-Ribosylation Factor 1; Arginine; Carrier Proteins; Coatomer Protein; GTPase-Activating Proteins; Guanosine Triphosphate; Hydrolysis; Mutation; Myristic Acid; Phospholipids; Protein Processing, Post-Translational; Sequence Deletion | 2000 |
Biochemical characterization of Rab3-GTPase-activating protein reveals a mechanism similar to that of Ras-GAP.
Topics: Aluminum Compounds; Amino Acid Sequence; Animals; Arginine; Binding Sites; Calcium; Calmodulin; Catalysis; Fluorides; GTP-Binding Proteins; GTPase-Activating Proteins; Guanine Nucleotides; Guanosine Triphosphate; Kinetics; Molecular Sequence Data; Mutation; Protein Binding; rab3 GTP-Binding Proteins; rab3A GTP-Binding Protein; ras GTPase-Activating Proteins; Recombinant Fusion Proteins; Sequence Alignment; Substrate Specificity; Thermodynamics | 2000 |
Arginines 29 and 59 of elongation factor G are important for GTP hydrolysis or translocation on the ribosome.
Topics: Arginine; Biological Transport; GTP Phosphohydrolases; Guanosine Triphosphate; Hydrolysis; Peptide Elongation Factor G; Ribosomes | 2000 |
Three-dimensional view of the surface motif associated with the P-loop structure: cis and trans cases of convergent evolution.
Topics: Adenosine Triphosphate; Alanine; Amino Acid Motifs; Amino Acid Sequence; Animals; Arginine; Asparagine; Binding Sites; Conserved Sequence; Evolution, Molecular; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Models, Molecular; Molecular Sequence Data; Nucleoside-Phosphate Kinase; Protein Structure, Tertiary; Ribonucleases; Sequence Alignment; Static Electricity; Substrate Specificity | 2000 |
Role of intrahelical arginine residues in functional properties of uncoupling protein (UCP1).
Topics: Animals; Arginine; Binding Sites; Biological Transport, Active; Carbon Radioisotopes; Carrier Proteins; Chloride Channels; Cricetinae; Genetic Vectors; Guanosine Triphosphate; Intracellular Fluid; Intracellular Membranes; Ion Channels; Lauric Acids; Membrane Proteins; Mitochondria; Mitochondrial Proteins; Mutagenesis, Site-Directed; Permeability; Protein Structure, Secondary; Protons; Saccharomyces cerevisiae; Uncoupling Agents; Uncoupling Protein 1 | 2001 |
The arginine finger of RasGAP helps Gln-61 align the nucleophilic water in GAP-stimulated hydrolysis of GTP.
Topics: Arginine; Binding Sites; Cluster Analysis; Glutamine; Guanosine Triphosphate; Hydrolysis; p120 GTPase Activating Protein; Proto-Oncogene Proteins p21(ras); Water | 2001 |
Dimerization of small GTPase Rab5.
Topics: Amino Acid Sequence; Arginine; Cell Line; Cross-Linking Reagents; Dimerization; Guanosine Triphosphate; Humans; Molecular Sequence Data; Mutation; Plasmids; Protein Binding; Proteins; rab5 GTP-Binding Proteins; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Two-Hybrid System Techniques | 2001 |
Crystal structure of pea Toc34, a novel GTPase of the chloroplast protein translocon.
Topics: Amino Acid Motifs; Amino Acid Sequence; Arginine; Binding Sites; Chloroplasts; Chromatography, Gel; Crystallography, X-Ray; Cytosol; Dimerization; GTP Phosphohydrolases; GTPase-Activating Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Magnesium; Membrane Proteins; Models, Molecular; Molecular Sequence Data; Mutation; Pisum sativum; Plant Proteins; Protein Binding; Protein Conformation; Protein Transport; Sequence Alignment | 2002 |
RanGAP mediates GTP hydrolysis without an arginine finger.
Topics: Arginine; Catalytic Domain; Crystallography, X-Ray; Escherichia coli; GTPase-Activating Proteins; Guanosine Triphosphate; Humans; Hydrolysis; Models, Molecular; Nuclear Proteins; Protein Conformation; Protein Structure, Tertiary; ran GTP-Binding Protein; Recombinant Proteins; Schizosaccharomyces | 2002 |
The direct stimulation of Gi proteins by neuropeptide Y (NPY) in the rat left ventricle.
Topics: Animals; Antibodies; Arginine; Cell Membrane; Colforsin; Cyclic AMP; Drug Interactions; GTP Phosphohydrolases; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine Triphosphate; Heart Ventricles; Hydrolysis; Kinetics; Male; Neuropeptide Y; Rats; Rats, Wistar; Ventricular Function, Left | 2002 |
Substitution of Ser for Arg-443 in the regulatory domain of human housekeeping (GLUD1) glutamate dehydrogenase virtually abolishes basal activity and markedly alters the activation of the enzyme by ADP and L-leucine.
Topics: Adenosine Diphosphate; Allosteric Regulation; Amino Acid Sequence; Animals; Arginine; Buffers; Catalysis; Cell Line; Cloning, Molecular; Crystallography, X-Ray; Enzyme Activation; Enzyme Inhibitors; Glutamate Dehydrogenase; Guanosine Triphosphate; Humans; Hydrogen-Ion Concentration; Kinetics; Leucine; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Spodoptera | 2002 |
Understanding the catalytic mechanism of GTPase-activating proteins: demonstration of the importance of switch domain stabilization in the stimulation of GTP hydrolysis.
Topics: Amino Acid Sequence; Amino Acid Substitution; Arginine; Binding Sites; Catalysis; cdc42 GTP-Binding Protein; Enzyme Stability; GTPase-Activating Proteins; Guanosine Triphosphate; Humans; Hydrolysis; Molecular Sequence Data; Protein Binding; Protein Structure, Tertiary; Spectrometry, Fluorescence; Tyrosine | 2002 |
Thr-431 and Arg-433 are part of a conserved sequence motif of the glutamine amidotransferase domain of CTP synthases and are involved in GTP activation of the Lactococcus lactis enzyme.
Topics: Adenosine Triphosphate; Allosteric Site; Amino Acid Motifs; Amino Acid Sequence; Ammonium Chloride; Anthranilate Synthase; Arginine; Carbon-Nitrogen Ligases; DNA; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Glutaminase; Guanosine Triphosphate; Kinetics; Lactococcus lactis; Methionine; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Nitrogenous Group Transferases; Protein Binding; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Signal Transduction; Threonine; Valine | 2003 |
Limited proteolysis of Escherichia coli cytidine 5'-triphosphate synthase. Identification of residues required for CTP formation and GTP-dependent activation of glutamine hydrolysis.
Topics: Amino Acid Sequence; Arginine; Binding Sites; Carbon-Nitrogen Ligases; Catalysis; Circular Dichroism; Cytidine Triphosphate; Dimerization; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Escherichia coli; Glutaminase; Glutamine; Guanosine Triphosphate; Hydrolysis; Kinetics; Lysine; Models, Chemical; Models, Genetic; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Plasmids; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Proteins; Sequence Homology, Amino Acid; Time Factors; Trypsin | 2003 |
Conformational changes in the phosphorylated C-terminal domain of rhodopsin during rhodopsin arrestin interactions.
Topics: Animals; Arginine; Arrestins; Binding Sites; Cattle; Cytoplasm; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine Triphosphate; Lysine; Magnetic Resonance Spectroscopy; Models, Molecular; Peptides; Phosphorylation; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Rhodopsin; Serine; Signal Transduction | 2004 |
Mutation of the highly conserved Arg165 and Glu168 residues of human Gsalpha disrupts the alphaD-alphaE loop and enhances basal GDP/GTP exchange rate.
Topics: Adenylyl Cyclases; Arginine; Conserved Sequence; Crystallography, X-Ray; Glutamic Acid; GTP-Binding Protein alpha Subunits, Gs; Guanosine Diphosphate; Guanosine Triphosphate; Humans; Hydrogen Bonding; Kinetics; Models, Molecular; Mutation; Protein Structure, Tertiary | 2004 |
Estimation of EDRF and nitric oxide release using [3H]GTP-labeled human platelets.
Topics: Animals; Arginine; Biological Assay; Blood Platelets; Bradykinin; Cattle; Cell Count; Cells, Cultured; Coculture Techniques; Cyclic GMP; Drug Interactions; Endothelium-Dependent Relaxing Factors; Endothelium, Vascular; Guanosine Triphosphate; Humans; Nitric Oxide; Nitroprusside; Superoxide Dismutase; Tritium | 1995 |
Structural basis for the unique biological function of small GTPase RHEB.
Topics: Amino Acid Sequence; Arginine; Asparagine; Binding Sites; Catalytic Domain; Cell Proliferation; Crystallography, X-Ray; Databases, Protein; GTP Phosphohydrolases; Guanosine Diphosphate; Guanosine Triphosphate; Humans; Hydrolysis; Magnesium; Models, Molecular; Molecular Sequence Data; Monomeric GTP-Binding Proteins; Neuropeptides; Protein Conformation; Protein Kinases; Protein Structure, Secondary; Protein Structure, Tertiary; Ras Homolog Enriched in Brain Protein; ras Proteins; Repressor Proteins; Sequence Homology, Amino Acid; TOR Serine-Threonine Kinases; Tuberous Sclerosis; Tuberous Sclerosis Complex 1 Protein; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins; X-Ray Diffraction | 2005 |
Effects of mutagenesis in the switch I region and conserved arginines of Escherichia coli MnmE protein, a GTPase involved in tRNA modification.
Topics: Arginine; Cell Survival; DNA Mutational Analysis; Escherichia coli; Escherichia coli Proteins; GTP Phosphohydrolases; Guanosine Triphosphate; Humans; Molecular Structure; Mutagenesis, Site-Directed; Protein Conformation; RNA, Transfer | 2005 |
HANP1/H1T2, a novel histone H1-like protein involved in nuclear formation and sperm fertility.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Arginine; Base Sequence; Binding Sites; Cell Differentiation; Cell Nucleus; Chromatin; DNA; DNA-Binding Proteins; DNA, Complementary; Dose-Response Relationship, Drug; Epididymis; Female; Fertility; Fertilization; Genetic Vectors; Guanosine Triphosphate; Haploidy; Heterozygote; Histones; Homozygote; Male; Mice; Mice, Knockout; Microscopy, Electron; Models, Genetic; Molecular Sequence Data; Mutation; Nuclear Proteins; Phylogeny; Protamines; Protein Binding; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Spermatids; Spermatozoa; Testis; Time Factors; Tissue Distribution | 2005 |
A switch 3 point mutation in the alpha subunit of transducin yields a unique dominant-negative inhibitor.
Topics: Aluminum Compounds; Animals; Arginine; Catalysis; Cattle; Chromatography, High Pressure Liquid; Cyclic GMP; Dose-Response Relationship, Drug; Fluorides; Genes, Dominant; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Models, Biological; Models, Molecular; Mutation; Nucleotides; Point Mutation; Protein Conformation; Recombinant Fusion Proteins; Recombinant Proteins; Retina; Rhodopsin; Signal Transduction; Spectrometry, Fluorescence; Time Factors; Transducin; Trypsin | 2005 |
Functional analysis of backbone cyclic peptides bearing the arm domain of the HIV-1 Rev protein: characterization of the karyophilic properties and inhibition of Rev-induced gene expression.
Topics: Amino Acid Sequence; Arginine; Binding Sites; Gene Expression Regulation, Viral; Gene Products, rev; Guanosine Triphosphate; HeLa Cells; HIV-1; Humans; Peptide Library; Peptides, Cyclic; Protein Conformation; Recombinant Proteins; rev Gene Products, Human Immunodeficiency Virus | 2005 |
Crystal structure of the GTPase domain of rat dynamin 1.
Topics: Animals; Arginine; Catalysis; Crystallization; Crystallography, X-Ray; Dynamin I; Enzyme Activation; GTP Phosphohydrolases; Guanosine Triphosphate; Kinetics; Mutation; Protein Structure, Tertiary; Rats | 2005 |
New insights into the role of conserved, essential residues in the GTP binding/GTP hydrolytic cycle of large G proteins.
Topics: Arginine; Escherichia coli; Glutamine; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Hydrolysis; Mutagenesis, Site-Directed; Receptors, G-Protein-Coupled; Rhodopsin; Signal Transduction; Transducin | 2006 |
Interactions of GTP with the ATP-grasp domain of GTP-specific succinyl-CoA synthetase.
Topics: Adenosine Triphosphate; Animals; Arginine; Binding Sites; Crystallography, X-Ray; Glutamine; Guanine; Guanosine Triphosphate; Histidine; Hydrolysis; Models, Molecular; Nitrogen; Phosphates; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Protein Conformation; Protein Isoforms; Ribose; Succinate-CoA Ligases; Swine | 2006 |
How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP.
Topics: Arginine; Binding Sites; Catalysis; Crystallography, X-Ray; Dimerization; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine Diphosphate; Guanosine Monophosphate; Guanosine Triphosphate; Humans; Hydrolysis; Models, Molecular; Phosphates; Protein Binding; Protein Structure, Quaternary; Protein Structure, Tertiary; Serine; Structure-Activity Relationship | 2006 |
Mutation of a critical arginine in the GTP-binding site of transglutaminase 2 disinhibits intracellular cross-linking activity.
Topics: Animals; Arginine; Binding Sites; Calcium; Cell Line, Tumor; Cross-Linking Reagents; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Models, Molecular; Mutation; Protein Glutamine gamma Glutamyltransferase 2; Protein Processing, Post-Translational; Rats; Serine; Transglutaminases; Trypsin | 2006 |
Mechanism of allosteric regulation of transglutaminase 2 by GTP.
Topics: Allosteric Regulation; Animals; Arginine; Binding Sites; Cysteine; Disulfides; GTP-Binding Proteins; Guanosine Triphosphate; Hydrogen Bonding; Models, Molecular; Mutation; Protein Binding; Protein Glutamine gamma Glutamyltransferase 2; Protein Structure, Tertiary; Rats; Transglutaminases; Tyrosine; Water | 2006 |
The crystal structure of the third signal-recognition particle GTPase FlhF reveals a homodimer with bound GTP.
Topics: Amino Acid Motifs; Arginine; Bacillus subtilis; Bacterial Proteins; Binding Sites; Catalysis; Crystallography, X-Ray; Dimerization; Guanosine Triphosphate; Hydrolysis; Models, Molecular; Monomeric GTP-Binding Proteins; Protein Structure, Quaternary; Protein Structure, Tertiary; Sequence Alignment; Structural Homology, Protein | 2007 |
Role of the arginine finger in Ras.RasGAP revealed by QM/MM calculations.
Topics: Arginine; Catalysis; Computational Biology; Guanosine Triphosphate; Hydrogen Bonding; Hydrolysis; Models, Molecular; Protein Conformation; ras GTPase-Activating Proteins; ras Proteins; Static Electricity; Structure-Activity Relationship | 2007 |
The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues.
Topics: Amino Acid Sequence; Arginine; Binding Sites; Catalysis; Crystallography, X-Ray; Glutamine; GTPase-Activating Proteins; Guanosine Triphosphate; Hydrolysis; Models, Molecular; Molecular Sequence Data; Mutant Proteins; Protein Binding; Protein Structure, Secondary; rap1 GTP-Binding Proteins; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins | 2008 |
The site for the allosteric activator GTP of Escherichia coli UMP kinase.
Topics: Alanine; Allosteric Regulation; Amino Acid Substitution; Arginine; Binding Sites; Enzyme Activation; Escherichia coli; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Histidine; Mutagenesis; Mutation; Nucleoside-Phosphate Kinase; Protein Conformation; Uridine Triphosphate | 2009 |
Promiscuous usage of nucleotides by the DNA helicase of bacteriophage T7: determinants of nucleotide specificity.
Topics: Adenosine Triphosphate; Amino Acid Substitution; Arginine; Bacteriophage T7; Crystallography, X-Ray; Cytidine Triphosphate; DNA; DNA Helicases; DNA-Directed DNA Polymerase; Guanosine Triphosphate; Hydrolysis; Kinetics; Mutant Proteins; Nucleotides; Plasmids; Protein Binding; Protein Structure, Quaternary; Protein Structure, Secondary; Substrate Specificity; Thymine Nucleotides | 2009 |
Transition state structures and the roles of catalytic residues in GAP-facilitated GTPase of Ras as elucidated by (18)O kinetic isotope effects.
Topics: Animals; Arginine; Biocatalysis; Conserved Sequence; Electrons; GTPase-Activating Proteins; Guanosine Triphosphate; Humans; Hydrolysis; Kinetics; Mice; Models, Molecular; Mutation; Oxygen Isotopes; Protein Conformation; ras Proteins; Staining and Labeling | 2009 |
The C1 homodimer of adenylyl cyclase binds nucleotides with high affinity but possesses exceedingly low catalytic activity.
Topics: Adenosine Triphosphate; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Arginine; Enzyme Inhibitors; Fluorescence; Fluorescence Resonance Energy Transfer; Guanosine Triphosphate; Histidine; Manganese; Models, Chemical; Models, Molecular; Nucleotides; Protein Multimerization | 2009 |
Insight into the molecular switch mechanism of human Rab5a from molecular dynamics simulations.
Topics: Arginine; Catalytic Domain; Crystallography, X-Ray; Guanosine Triphosphate; Humans; Molecular Dynamics Simulation; Mutation; Proline; Protein Structure, Secondary; rab5 GTP-Binding Proteins | 2009 |
Opposing effects of two tissue transglutaminase protein isoforms in neuroblastoma cell differentiation.
Topics: Arginine; Binding Sites; Cell Differentiation; Cell Line, Tumor; Drug Resistance, Neoplasm; Gene Expression Regulation, Enzymologic; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Immunoblotting; Isoenzymes; Neurites; Neuroblastoma; Protein Binding; Protein Glutamine gamma Glutamyltransferase 2; Proto-Oncogene Proteins c-myc; Retinoids; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Transfection; Transglutaminases; Vasoactive Intestinal Peptide | 2010 |
Molecular basis of a novel oncogenic mutation in GNAO1.
Topics: Adenosine Triphosphatases; Amino Acid Sequence; Amino Acid Substitution; Animals; Arginine; Binding Sites; Biocatalysis; Cell Line, Tumor; Cell Transformation, Neoplastic; GTP-Binding Protein alpha Subunits, Gi-Go; GTPase-Activating Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Histidine; Humans; Mice; Models, Molecular; Mutation; NIH 3T3 Cells; Protein Structure, Secondary; Protein Structure, Tertiary; Proto-Oncogene Proteins pp60(c-src); Sequence Homology, Amino Acid; Signal Transduction; STAT3 Transcription Factor | 2011 |
Structural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarity.
Topics: Amino Acid Sequence; Arginine; Bacterial Proteins; Catalysis; Catalytic Domain; Cell Polarity; Glutamine; Guanosine Triphosphate; Hydrolysis; Molecular Sequence Data; Myxococcus xanthus; Protein Conformation; ras Proteins | 2011 |
The guanine cap of human guanylate-binding protein 1 is responsible for dimerization and self-activation of GTP hydrolysis.
Topics: Amino Acid Motifs; Amino Acid Substitution; Arginine; Binding Sites; Databases, Protein; Dimerization; Enzyme Activation; GTP-Binding Proteins; Guanine; Guanosine Triphosphate; Humans; Hydrolysis; Kinetics; Lysine; Models, Molecular; Mutagenesis, Site-Directed; Mutant Proteins; Protein Binding; Protein Conformation; Recombinant Proteins | 2012 |
[The changes of metabolism in myocardium at ischemia-reperfusion and activating of the ATP-sensitive potassium channels].
Topics: Adenosine Triphosphate; Animals; Apoptosis; Arachidonic Acid; Arginase; Arginine; Dogs; Eicosanoids; Guanosine Triphosphate; Heme; KATP Channels; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardium; Nitrate Reductase (NADH); Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Pinacidil; Reactive Nitrogen Species; Reactive Oxygen Species; Reperfusion Injury | 2012 |
Structural basis unifying diverse GTP hydrolysis mechanisms.
Topics: Arginine; Binding Sites; Catalysis; Catalytic Domain; Glutamine; GTP Phosphohydrolases; GTPase-Activating Proteins; Guanosine Triphosphate; Humans; Hydrolysis; Models, Molecular; Protein Conformation; ras Proteins | 2013 |
The C-terminal helix in the YjeQ zinc-finger domain catalyzes the release of RbfA during 30S ribosome subunit assembly.
Topics: Arginine; Binding Sites; Circular Dichroism; Enzyme Stability; Escherichia coli; Escherichia coli Proteins; GTP Phosphohydrolases; Guanosine Triphosphate; Lysine; Models, Molecular; Ribosomal Proteins; Ribosome Subunits, Small, Bacterial; Zinc Fingers | 2015 |
The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B.
Topics: Amino Acid Sequence; Arginine; Biocatalysis; Catalytic Domain; Gene Expression; Glutamine; Glycine; Guanosine Diphosphate; Guanosine Triphosphate; Humans; Hydrolysis; Molecular Dynamics Simulation; Mutation; Neoplasm Proteins; Protein Structure, Secondary; Proto-Oncogene Proteins p21(ras) | 2016 |
Noncanonical Myo9b-RhoGAP Accelerates RhoA GTP Hydrolysis by a Dual-Arginine-Finger Mechanism.
Topics: Arginine; Catalysis; Catalytic Domain; Fluorides; GTPase-Activating Proteins; Guanosine Triphosphate; Humans; Hydrolysis; Magnesium Compounds; Myosins; Protein Binding; rho GTP-Binding Proteins; rhoA GTP-Binding Protein | 2016 |
Structural plasticity mediates distinct GAP-dependent GTP hydrolysis mechanisms in Rab33 and Rab5.
Topics: Amino Acid Sequence; Animals; Arginine; Catalysis; Catalytic Domain; Glutamine; GTPase-Activating Proteins; Guanosine Triphosphate; Humans; Kinetics; Mice; Models, Chemical; Models, Molecular; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Plasmodium falciparum; Protein Conformation; Protein Stability; Protozoan Proteins; rab GTP-Binding Proteins; rab1 GTP-Binding Proteins; rab5 GTP-Binding Proteins; Recombinant Fusion Proteins; Saccharomyces cerevisiae Proteins; Sequence Alignment; Structure-Activity Relationship | 2017 |
Atypical Switch-I Arginine plays a catalytic role in GTP hydrolysis by Rab21 from Entamoeba histolytica.
Topics: Amino Acid Motifs; Amino Acid Sequence; Arginine; Bacterial Proteins; Binding Sites; Biocatalysis; Entamoeba histolytica; Glutamine; Guanosine Triphosphate; Hydrolysis; Kinetics; Models, Molecular; Mutant Proteins; Protein Binding; rab GTP-Binding Proteins; Structure-Activity Relationship | 2018 |
Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases.
Topics: Amino Acid Substitution; Arginine; GTPase-Activating Proteins; Guanosine Triphosphate; Humans; Hydrolysis; Monomeric GTP-Binding Proteins; Mutation, Missense; Repressor Proteins; Tumor Suppressor Proteins | 2019 |
Millisecond molecular dynamics simulations of KRas-dimer formation and interfaces.
Topics: Arginine; Extracellular Signal-Regulated MAP Kinases; GTPase-Activating Proteins; Guanosine Triphosphate; Lipid Bilayers; Molecular Dynamics Simulation; Phosphates; raf Kinases; Serine | 2022 |
Crystal Structures of Flavivirus NS5 Guanylyltransferase Reveal a GMP-Arginine Adduct.
Topics: Arginine; Encephalitis Viruses, Tick-Borne; Flavivirus; Guanosine Triphosphate; Methyltransferases; Models, Molecular; Nucleotidyltransferases; RNA Caps; RNA, Viral; Viral Nonstructural Proteins | 2022 |
GAP positions catalytic H-Ras residue Q61 for GTP hydrolysis in molecular dynamics simulations, complicating chemical rescue of Ras deactivation.
Topics: Arginine; Catalysis; GTPase-Activating Proteins; Guanosine Triphosphate; Hydrolysis; Molecular Dynamics Simulation | 2023 |
Dietary supplementation with L-citrulline improves placental angiogenesis and embryonic survival in gilts.
Topics: Animals; Arginine; Citrulline; Dietary Supplements; Female; Guanosine Triphosphate; Placenta; Polyamines; Pregnancy; Swine | 2023 |
Collateral sensitivity to gemcitabine (2',2'-difluorodeoxycytidine) and cytosine arabinoside of daunorubicin- and VM-26-resistant variants of human small cell lung cancer cell lines.
Topics: Adenosine Triphosphate; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Carcinoma, Small Cell; Cell Survival; Cytarabine; Cytidine Deaminase; Daunorubicin; Deoxycytidine; Deoxycytidine Kinase; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Gemcitabine; Guanosine Triphosphate; Humans; Lung Neoplasms; Nucleoside Deaminases; Teniposide; Thymidine Kinase; Tumor Cells, Cultured; Uridine Triphosphate | 2001 |