Compounds > arginine

arginine and amsacrine

arginine has been researched along with amsacrine in 72 studies

Research

Studies (72)

TimeframeStudies, this research(%)All Research%
pre-199021 (29.17)18.7374
1990's47 (65.28)18.2507
2000's3 (4.17)29.6817
2010's1 (1.39)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Duncan, D; Hsiung, Y; Jannatipour, M; McMahon, J; Nitiss, JL; Rose, A1
Fisher, LM; Keller, BA; Patel, S1
Nishioka, WK; Welsh, RM1
Kohn, KW; Orr, A; Pommier, Y; Riou, JF1
Constantinou, A; Grdina, D; Huberman, E; Kiguchi, K1
DeMarini, DM; Lawrence, BK1
Lorico, A; Rappa, G; Sartorelli, AC1
Darzynkiewicz, Z; Del Bino, G; Hotz, MA; Lassota, P; Traganos, F1
Busch, FW; Ehninger, G; Hiddemann, W; Jaschonek, K; Proksch, B; Schleyer, E; Schmidt, H; Schuler, U; Wanner, T1
Bae, YS; Chiba, M; Ikeda, H; Ohira, M1
Darzynkiewicz, Z; Del Bino, G; Skierski, JS1
Beck, WT; Danks, MK1
Adachi, K; Andrea, JE; Morgan, AR1
Capranico, G; Kohn, KW; Orr, A; Pommier, Y2
Adams, DJ; Bair, KW; Elstein, KH; Zucker, RM1
Gewirtz, DA1
Lihou, MG; Smith, PJ; Tomlinson, FH1
Suciu, D1
Chang, EH; Cunningham, JM; Francis, GE; Holland, MJ; Pirollo, KF1
Leblanc, J; Sikorska, M; Smith, C; Walker, PR; Whitfield, JF; Youdale, T1
Castora, FJ; Lin, JH2
Darzynkiewicz, Z; Del Bino, G1
Evans, WE; Mirro, J; Petros, WP; Rodman, JH1
Gupta, R1
Capranico, G; Kohn, KW; Pommier, Y; Zunino, F1
Beck, WT; Danks, MK; Fernandes, DJ1
Elkind, MM; Shibuya, ML; Utsumi, H1
Drake, FH; Hofmann, GA; Mirabelli, CK1
Beerman, TA; Sigmund, RD; Woynarowski, JM2
Bartus, JO; Drake, FH; Hertzberg, RP; Hofmann, GA; Johnson, RK; Mattern, MR; Mirabelli, CK; Mong, SM1
Davies, SL; Davies, SM; Harris, AL; Hickson, ID1
Beerman, TA; Cullinan, EB1
Lefevre, D; Riou, G; Riou, JF1
Beck, WT; Danks, MK; Deneka, DA; Schmidt, CA1
Dahl, GV; Grier, HE; Kalwinsky, DK; Mason, C; Mirro, J; Murphy, SB; Santana, VM1
Larsen, CJ; Multon, E; Riou, GF; Riou, JF; Vilarem, MJ1
Boyce, RA; Hertzberg, RP; Mattern, MR; Schein, PS; Tan, KB1
Benson, JD; Huang, ES1
Jacobson-Kram, D; Lim, M; Liu, LF; Williams, JR1
Larsen, CJ; Multon, E; Riou, G; Riou, JF; Vilarem, MJ1
Mui, SC; Strauss, PR; Todt, JC; Zhang, LH1
Bezwoda, WR; Derman, DP; Kew, M; Weaving, A1
Fernandes, DJ; Neff, TA; Paff, MT; Smith-Nanni, C1
Hungerford, JL; Kingston, JE; Plowman, PN1
Brattain, MG; Long, BH; Musial, ST1
Creech, RH; Ettinger, DS; Ferraro, JA; Ruckdeschel, JC; Tritchler, D; Vogl, SE; Woll, J1
Crom, WR; Evans, WE; Hutson, PR; Sinkule, JA; Stewart, CF; Yee, GC1
Gahrton, G1
Beerman, TA; Johnson, PG1
Chung, IK; Gootz, TD; McGuirk, PR; Muller, MT; Spitzner, JR1
Coughlin, SA; Evans, AC; Huff, AC; Rake, JB; Robinson, RG; Selander, KN; Wentland, MP1
Gupta, M; Jenkins, J; Poddevin, B; Pommier, Y1
Gromova, II; Razin, SV; Thomsen, B1
Beck, WT; Catapano, CV; Danks, MK; Fernandes, DJ; Qiu, J; Schmidt, CA1
Wang, JC; Wasserman, RA1
Joel, SP; Slevin, ML1
Inaba, M; Kawada, S; Mitsuhashi, J; Nakano, H1
Capranico, G; Kohn, KW; Pommier, Y; Tinelli, S; Zunino, F1
de Jong, S; de Vries, EG; Kooistra, AJ; Mulder, NH; Zijlstra, JG1
Darzynkiewicz, Z; Gorczyca, W; Melamed, MR1
Bigioni, M; Capranico, G; De Isabella, P; Tinelli, S; Zunino, F1
Austin, CA; Bigioni, M; Capranico, G; Tinelli, S; Willmore, E; Zunino, F1
Borgnetto, ME; Capranico, G; Kas, E; Tinelli, S; Zunino, F1
de Vries, EG; Keith, WN; Mulder, NH; Nienhuis, EF; Uges, DR; van der Graaf, WT; Withoff, S1
Holm, B; Jensen, PB; Sehested, M1
Bianco, C; Ciardiello, F; Damiano, V; Davies, SL; di Isernia, G; Harris, AL; Hickson, ID; North, P; Pepe, S; Tortora, G1
Hsieh, TS; Hu, T; Liu, LF; Mao, Y; Wang, H; Zhou, N1

Reviews

6 review(s) available for arginine and amsacrine

ArticleYear
Mechanisms of resistance to drugs that inhibit DNA topoisomerases.
    Seminars in cancer biology, 1991, Volume: 2, Issue:4

    Topics: Amsacrine; Animals; Antineoplastic Agents; Camptothecin; Cricetinae; Daunorubicin; DNA Replication; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Doxorubicin; Drug Resistance; Etoposide; Humans; Mice; Teniposide; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1991
Does bulk damage to DNA explain the cytostatic and cytotoxic effects of topoisomerase II inhibitors?
    Biochemical pharmacology, 1991, Nov-27, Volume: 42, Issue:12

    Topics: Amsacrine; Animals; Antineoplastic Agents; Cell Division; Cell Line; Cell Survival; DNA; DNA Damage; Etoposide; Humans; Teniposide; Topoisomerase II Inhibitors

1991
Pharmacokinetics of anticancer drugs in children.
    Drug metabolism reviews, 1983, Volume: 14, Issue:5

    Topics: Aminoacridines; Amsacrine; Antibiotics, Antineoplastic; Antineoplastic Agents; Bleomycin; Child; Cyclophosphamide; Etoposide; Humans; Kinetics; Mercaptopurine; Methotrexate; Naphthacenes; Podophyllotoxin; Teniposide; Vinca Alkaloids

1983
Treatment of acute leukemia--advances in chemotherapy, immunotherapy, and bone marrow transplantation.
    Advances in cancer research, 1983, Volume: 40

    Topics: Aclarubicin; Acute Disease; Adolescent; Adult; Age Factors; Aminoacridines; Amsacrine; Anthraquinones; Antibodies, Monoclonal; Azacitidine; Bone Marrow Transplantation; Child; Child, Preschool; Drug Administration Schedule; Etoposide; Humans; Ifosfamide; Immunotherapy; Infant; Interferons; Leukemia; Leukemia, Lymphoid; Liposomes; Middle Aged; Mitoxantrone; Naphthacenes; Prognosis; Teniposide; Transplantation, Homologous; Transplantation, Isogeneic; Vinblastine; Vindesine

1983
Schedule-dependent topoisomerase II-inhibiting drugs.
    Cancer chemotherapy and pharmacology, 1994, Volume: 34 Suppl

    Topics: Amsacrine; Antibiotics, Antineoplastic; Antineoplastic Agents; Cell Cycle; Clinical Trials, Phase I as Topic; DNA Repair; Drug Administration Schedule; Etoposide; Humans; Metabolic Clearance Rate; Neoplasms; Teniposide; Topoisomerase II Inhibitors

1994
DNA topoisomerase II inhibitors.
    IARC monographs on the evaluation of carcinogenic risks to humans, 2000, Volume: 76

    Topics: Amsacrine; Antineoplastic Agents; Carcinogens; Disease Models, Animal; Etoposide; Evidence-Based Medicine; Humans; Intestinal Absorption; Mitoxantrone; Neoplasms; Nucleic Acid Synthesis Inhibitors; Research Design; Risk Factors; Teniposide; Tissue Distribution; Topoisomerase II Inhibitors

2000

Trials

2 trial(s) available for arginine and amsacrine

ArticleYear
Combination chemotherapy of hepatocellular cancer. Comparison of adriamycin + VM 26 + 5-fluorouracil with mAMSA + VM 26 + 5-fluorouracil.
    Oncology, 1987, Volume: 44, Issue:4

    Topics: Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Clinical Trials as Topic; Doxorubicin; Female; Fluorouracil; Humans; Liver Neoplasms; Male; Podophyllotoxin; Random Allocation; Teniposide; Time Factors

1987
Phase II study of PALA, amsacrine, teniposide, and zinostatin in small cell lung carcinoma (EST 2579).
    Cancer treatment reports, 1984, Volume: 68, Issue:9

    Topics: Aminoacridines; Amsacrine; Antibiotics, Antineoplastic; Antineoplastic Agents; Aspartic Acid; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Drug Evaluation; Humans; Lung Neoplasms; Phosphonoacetic Acid; Random Allocation; Teniposide; Zinostatin

1984

Other Studies

64 other study(ies) available for arginine and amsacrine

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Functional expression of human topoisomerase II alpha in yeast: mutations at amino acids 450 or 803 of topoisomerase II alpha result in enzymes that can confer resistance to anti-topoisomerase II agents.
    Cancer research, 1996, Jan-01, Volume: 56, Issue:1

    Topics: Alleles; Amsacrine; Antineoplastic Agents; Arginine; Base Sequence; DNA Topoisomerases, Type II; Drug Resistance; Humans; Molecular Sequence Data; Point Mutation; Proline; Saccharomyces cerevisiae; Teniposide

1996
Mutations at arg486 and glu571 in human topoisomerase IIalpha confer resistance to amsacrine: relevance for antitumor drug resistance in human cells.
    Molecular pharmacology, 2000, Volume: 57, Issue:4

    Topics: Amsacrine; Antigens, Neoplasm; Antineoplastic Agents; Arginine; DNA; DNA Topoisomerases, Type II; DNA-Binding Proteins; Drug Resistance, Neoplasm; Etoposide; Glutamic Acid; Humans; Isoenzymes; Point Mutation; Saccharomyces cerevisiae; Tumor Cells, Cultured

2000
Inhibition of cytotoxic T lymphocyte-induced target cell DNA fragmentation, but not lysis, by inhibitors of DNA topoisomerases I and II.
    The Journal of experimental medicine, 1992, Jan-01, Volume: 175, Issue:1

    Topics: Amsacrine; Animals; Camptothecin; Cells, Cultured; Cytotoxicity, Immunologic; DNA; DNA Damage; Female; Killer Cells, Natural; Lymphocyte Depletion; Lymphocytic choriomeningitis virus; Male; Mice; Mice, Inbred Strains; T-Lymphocytes, Cytotoxic; Teniposide; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1992
Differential effects of amsacrine and epipodophyllotoxins on topoisomerase II cleavage in the human c-myc protooncogene.
    Cancer research, 1992, Jun-01, Volume: 52, Issue:11

    Topics: Amsacrine; Animals; Base Sequence; Binding Sites; Carcinoma, Small Cell; Cell Line; DNA Damage; DNA Topoisomerases, Type II; DNA, Neoplasm; Etoposide; Genes, myc; Humans; Leukemia L1210; Lung Neoplasms; Mice; Molecular Sequence Data; Promoter Regions, Genetic; Restriction Mapping; Substrate Specificity; Teniposide

1992
The effect of topoisomerase inhibitors on the expression of differentiation markers and cell cycle progression in human K-562 leukemia cells.
    Experimental cell research, 1992, Volume: 203, Issue:1

    Topics: Amsacrine; Aphidicolin; Cell Cycle; Cell Differentiation; Cycloheximide; Deoxyadenosines; Dose-Response Relationship, Drug; Etoposide; G2 Phase; Hemoglobins; Humans; Kinetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Melanins; Mitosis; Novobiocin; Teniposide; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1992
Prophage induction by DNA topoisomerase II poisons and reactive-oxygen species: role of DNA breaks.
    Mutation research, 1992, Volume: 267, Issue:1

    Topics: Amsacrine; Azides; Bacteriophage lambda; Dactinomycin; DNA Damage; Dose-Response Relationship, Drug; Doxorubicin; Ellipticines; Escherichia coli; Free Radicals; Hydrogen Peroxide; Lysogeny; Nalidixic Acid; Novobiocin; Oxolinic Acid; Oxygen; Paraquat; Sodium Azide; SOS Response, Genetics; Teniposide; Topoisomerase II Inhibitors; Virus Replication

1992
Potentiation by novobiocin of the cytotoxic activity of etoposide (VP-16) and teniposide (VM-26).
    International journal of cancer, 1992, Jul-09, Volume: 51, Issue:5

    Topics: Adenocarcinoma; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cell Survival; DNA; DNA Topoisomerases, Type II; Drug Synergism; Etoposide; Humans; Leukemia; Lung Neoplasms; Novobiocin; RNA; Teniposide; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1992
Cytostatic and cytotoxic effects of fostriecin on human promyelocytic HL-60 and lymphocytic MOLT-4 leukemic cells.
    Cancer research, 1992, Mar-15, Volume: 52, Issue:6

    Topics: Alkenes; Amsacrine; Antibiotics, Antineoplastic; Cell Cycle; DNA, Neoplasm; Humans; Leukemia, Lymphoid; Leukemia, Promyelocytic, Acute; Polyenes; Pyrones; Teniposide; Tumor Cells, Cultured

1992
Intracellular cytosine arabinoside accumulation and cytosine arabinoside triphosphate formation in leukemic blast cells is inhibited by etoposide and teniposide.
    Leukemia, 1992, Volume: 6, Issue:6

    Topics: Acute Disease; Adult; Aged; Amsacrine; Arabinofuranosylcytosine Triphosphate; Cytarabine; Drug Interactions; Etoposide; Humans; Leukemia; Middle Aged; Neoplastic Stem Cells; Phosphorylation; Teniposide; Tumor Cells, Cultured

1992
A shuttle vector for analysis of illegitimate recombination in mammalian cells: effects of DNA topoisomerase inhibitors on deletion frequency.
    Gene, 1991, May-30, Volume: 101, Issue:2

    Topics: Amsacrine; Animals; Camptothecin; Cell Line; Chromosome Deletion; DNA Topoisomerases, Type II; Genetic Vectors; Mutation; Plasmids; Recombination, Genetic; Restriction Mapping; Teniposide; Topoisomerase II Inhibitors

1991
The concentration-dependent diversity of effects of DNA topoisomerase I and II inhibitors on the cell cycle of HL-60 cells.
    Experimental cell research, 1991, Volume: 195, Issue:2

    Topics: Amsacrine; Camptothecin; Cell Cycle; DNA; Humans; Kinetics; Teniposide; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1991
Fluorometric assays for DNA topoisomerases and topoisomerase-targeted drugs: quantitation of catalytic activity and DNA cleavage.
    Molecular pharmacology, 1991, Volume: 40, Issue:4

    Topics: Amsacrine; Animals; Antineoplastic Agents; Camptothecin; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA, Circular; DNA, Single-Stranded; DNA, Superhelical; Ethidium; Fluorescence; Fluorometry; Hydrogen-Ion Concentration; Kinetics; Novobiocin; Teniposide; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1991
Local base sequence preferences for DNA cleavage by mammalian topoisomerase II in the presence of amsacrine or teniposide.
    Nucleic acids research, 1991, Nov-11, Volume: 19, Issue:21

    Topics: Amsacrine; Base Sequence; Binding Sites; DNA Topoisomerases, Type II; DNA, Viral; Doxorubicin; Models, Molecular; Molecular Sequence Data; Nucleic Acid Conformation; Simian virus 40; Teniposide

1991
Polyploidy induction as a consequence of topoisomerase inhibition. A flow cytometric assessment.
    Biochemical pharmacology, 1991, Nov-06, Volume: 42, Issue:11

    Topics: Amsacrine; Animals; Camptothecin; Doxorubicin; Flow Cytometry; Friend murine leukemia virus; G2 Phase; Leukemia, Erythroblastic, Acute; Mice; Polyploidy; Teniposide; Thymidine; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1991
Distribution of topoisomerase II cleavage sites in simian virus 40 DNA and the effects of drugs.
    Journal of molecular biology, 1991, Dec-20, Volume: 222, Issue:4

    Topics: Amsacrine; Animals; Base Sequence; Daunorubicin; DNA Damage; DNA Replication; DNA Topoisomerases, Type II; DNA, Viral; Ellipticines; Genome, Viral; Kinetics; Leukemia L1210; Mice; Molecular Sequence Data; Restriction Mapping; Simian virus 40; Substrate Specificity; Teniposide

1991
Comparison of in vitro activity of epipodophyllotoxins with other chemotherapeutic agents in human medulloblastomas.
    British journal of cancer, 1991, Volume: 64, Issue:6

    Topics: Alkylating Agents; Amsacrine; Cell Division; Cell Survival; Cross-Linking Reagents; Cytarabine; DNA Damage; DNA Topoisomerases, Type II; Drug Resistance; Etoposide; Humans; Hydroxyurea; In Vitro Techniques; Karyotyping; Medulloblastoma; Teniposide; Tumor Cells, Cultured; Vincristine

1991
Reproductive death of Chinese hamster V79 cells after exposure to chemical inhibitors of DNA synthesis.
    The International journal of biochemistry, 1991, Volume: 23, Issue:11

    Topics: 4-Nitroquinoline-1-oxide; Amsacrine; Animals; Benzamides; Bisbenzimidazole; Cell Division; Cell Line; Cisplatin; Cricetinae; Cricetulus; Cycloheximide; DNA Replication; Etoposide; Gene Expression Regulation; In Vitro Techniques; Kinetics; Methylnitronitrosoguanidine; Puromycin; Teniposide; Transcription, Genetic; Uracil

1991
Aberrant DNA topoisomerase II activity, radioresistance and inherited susceptibility to cancer.
    British journal of cancer, 1991, Volume: 63, Issue:1

    Topics: Amsacrine; Ataxia Telangiectasia; Cell Line; Cell Nucleus; Cell Transformation, Neoplastic; Cytarabine; Cytoplasm; DNA Repair; DNA Topoisomerases, Type II; DNA, Circular; DNA, Superhelical; Female; Fibroblasts; Gene Expression; Genetic Predisposition to Disease; Humans; Male; Neoplasms; Oncogenes; Radiation Tolerance; Teniposide; Topoisomerase II Inhibitors

1991
Topoisomerase II-reactive chemotherapeutic drugs induce apoptosis in thymocytes.
    Cancer research, 1991, Feb-15, Volume: 51, Issue:4

    Topics: Amsacrine; Animals; Cycloheximide; Dactinomycin; Dexamethasone; DNA; Electrophoresis; Etoposide; Flow Cytometry; Lymphocytes; Mitosis; Rats; Rats, Inbred Strains; Teniposide; Thymus Gland; Time Factors; Topoisomerase II Inhibitors

1991
DNA topoisomerase II from mammalian mitochondria is inhibited by the antitumor drugs, m-AMSA and VM-26.
    Biochemical and biophysical research communications, 1991, Apr-30, Volume: 176, Issue:2

    Topics: Amsacrine; Animals; Antineoplastic Agents; Cattle; Centrifugation; Chromatography; DNA-Directed DNA Polymerase; Mitochondria; Teniposide; Thymus Gland; Topoisomerase II Inhibitors

1991
Camptothecin, teniposide, or 4'-(9-acridinylamino)-3-methanesulfon-m-anisidide, but not mitoxantrone or doxorubicin, induces degradation of nuclear DNA in the S phase of HL-60 cells.
    Cancer research, 1991, Feb-15, Volume: 51, Issue:4

    Topics: Amsacrine; Camptothecin; Cell Line; DNA; Doxorubicin; Humans; In Vitro Techniques; Leukemia, Myeloid; Mitoxantrone; S Phase; Teniposide

1991
Pharmacokinetics of continuous-infusion amsacrine and teniposide for the treatment of relapsed childhood acute nonlymphocytic leukemia.
    Cancer chemotherapy and pharmacology, 1991, Volume: 27, Issue:5

    Topics: Adolescent; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Humans; Infant; Leukemia, Myeloid, Acute; Teniposide

1991
Tests for the genotoxicity of m-AMSA, etoposide, teniposide and ellipticine in Neurospora crassa.
    Mutation research, 1990, Volume: 240, Issue:2

    Topics: Alkaloids; Amsacrine; Ellipticines; Etoposide; Molecular Structure; Mutagenicity Tests; Mutagens; Neurospora crassa; Podophyllotoxin; Teniposide

1990
Sequence-selective topoisomerase II inhibition by anthracycline derivatives in SV40 DNA: relationship with DNA binding affinity and cytotoxicity.
    Biochemistry, 1990, Jan-16, Volume: 29, Issue:2

    Topics: Amsacrine; Animals; Antibiotics, Antineoplastic; Base Sequence; Daunorubicin; DNA, Viral; Doxorubicin; Leukemia P388; Mice; Molecular Sequence Data; Molecular Structure; Simian virus 40; Stereoisomerism; Structure-Activity Relationship; Teniposide; Topoisomerase II Inhibitors

1990
Decreased nuclear matrix DNA topoisomerase II in human leukemia cells resistant to VM-26 and m-AMSA.
    Biochemistry, 1990, May-01, Volume: 29, Issue:17

    Topics: Amsacrine; Animals; Antineoplastic Agents; Cell Nucleus; Crithidia; DNA; DNA Topoisomerases, Type II; Drug Resistance; Humans; Leukemia; Podophyllotoxin; Teniposide; Tumor Cells, Cultured

1990
Novobiocin inhibits the repair of potentially lethal damage but not the repair of sublethal damage.
    Radiation research, 1990, Volume: 123, Issue:1

    Topics: Amsacrine; Animals; Cell Line; Cricetinae; DNA Damage; DNA Repair; Etoposide; Novobiocin; Teniposide; Topoisomerase II Inhibitors

1990
Quantitative adaptation of the bacteriophage P4 DNA unknotting assay for use in the biochemical and pharmacological characterization of topoisomerase II.
    Anti-cancer drug design, 1990, Volume: 5, Issue:3

    Topics: Amsacrine; Bacteriophages; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Enzyme Inhibitors; Ethidium; Structure-Activity Relationship; Teniposide; Topoisomerase II Inhibitors

1990
DNA minor groove binding agents interfere with topoisomerase II mediated lesions induced by epipodophyllotoxin derivative VM-26 and acridine derivative m-AMSA in nuclei from L1210 cells.
    Biochemistry, 1989, May-02, Volume: 28, Issue:9

    Topics: Amsacrine; Animals; Bisbenzimidazole; Cell Nucleus; Deoxyribonucleoproteins; Distamycins; DNA Damage; DNA, Neoplasm; Indoles; Kinetics; Leukemia L1210; Mice; Podophyllotoxin; Teniposide; Topoisomerase II Inhibitors

1989
In vitro and intracellular inhibition of topoisomerase II by the antitumor agent merbarone.
    Cancer research, 1989, May-15, Volume: 49, Issue:10

    Topics: Amsacrine; Animals; Antineoplastic Agents; Camptothecin; DNA; DNA Damage; Leukemia, Experimental; Mice; Teniposide; Thiobarbiturates; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1989
Isolation of two Chinese hamster ovary cell mutants hypersensitive to topoisomerase II inhibitors and cross-resistant to peroxides.
    Cancer research, 1989, Aug-15, Volume: 49, Issue:16

    Topics: Amsacrine; Animals; Cell Line; Cell Survival; Cricetinae; Dactinomycin; DNA Topoisomerases, Type II; Doxorubicin; Drug Resistance; Etoposide; Female; Mitoxantrone; Mutation; Ovary; Teniposide; Topoisomerase II Inhibitors

1989
A study of drug-induced topoisomerase II-mediated DNA lesions on episomal chromatin.
    The Journal of biological chemistry, 1989, Sep-25, Volume: 264, Issue:27

    Topics: Amsacrine; Blotting, Southern; Cell Line; Chromatin; Dexamethasone; DNA Damage; DNA Topoisomerases, Type II; Genes; Kinetics; Plasmids; Podophyllotoxin; Teniposide

1989
Stimulation of the topoisomerase II induced DNA cleavage sites in the c-myc protooncogene by antitumor drugs is associated with gene expression.
    Biochemistry, 1989, Nov-14, Volume: 28, Issue:23

    Topics: Amsacrine; Animals; Antineoplastic Agents; DNA; DNA Topoisomerases, Type II; Gene Expression; Humans; Lymphocytes; Proto-Oncogenes; RNA, Messenger; Teniposide; Trypanosoma cruzi; Tumor Cells, Cultured

1989
Increased ATP requirement for activity of and complex formation by DNA topoisomerase II from human leukemic CCRF-CEM cells selected for resistance to teniposide.
    Cancer communications, 1989, Volume: 1, Issue:2

    Topics: Adenosine Triphosphate; Adenylyl Imidodiphosphate; Amsacrine; Cell Line; Cell Nucleus; DNA Topoisomerases, Type I; DNA, Neoplasm; Drug Resistance; Humans; Kinetics; Podophyllotoxin; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Binding; Teniposide; Tumor Cells, Cultured

1989
Effective reinduction therapy for childhood acute nonlymphoid leukemia using simultaneous continuous infusions of teniposide and amsacrine.
    Cancer chemotherapy and pharmacology, 1989, Volume: 24, Issue:2

    Topics: Adolescent; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Child; Child, Preschool; Drug Evaluation; Female; Humans; Infant; Infusions, Intravenous; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Leukopenia; Male; Mouth Mucosa; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Stomatitis; Teniposide; Thrombocytopenia

1989
In vivo and in vitro stimulation by antitumor drugs of the topoisomerase II-induced cleavage sites in c-myc proto-oncogene.
    NCI monographs : a publication of the National Cancer Institute, 1987, Issue:4

    Topics: Amsacrine; Antineoplastic Agents; Cell Line; DNA Restriction Enzymes; DNA Topoisomerases, Type II; DNA, Neoplasm; Humans; Nucleotide Mapping; Proto-Oncogene Mas; Proto-Oncogenes; Teniposide

1987
Elevated topoisomerase II activity and altered chromatin in nitrogen mustard-resistant human cells.
    NCI monographs : a publication of the National Cancer Institute, 1987, Issue:4

    Topics: Amsacrine; Burkitt Lymphoma; Cell Line; Cell Survival; Chromatin; DNA Topoisomerases, Type II; Drug Resistance; Humans; Kinetics; Mechlorethamine; Novobiocin; Podophyllotoxin; Teniposide; Tumor Stem Cell Assay

1987
Topoisomerase-II-mediated lesions in nascent DNA: comparison of the effects of epipodophyllotoxin derivatives, VM-26 and VP-16, and 9-anilinoacridine derivatives, m-AMSA and o-AMSA.
    Biochimica et biophysica acta, 1988, May-06, Volume: 950, Issue:1

    Topics: Adenosine Triphosphate; Amsacrine; Animals; Cross-Linking Reagents; DNA; DNA Damage; DNA Replication; DNA Topoisomerases, Type II; DNA, Neoplasm; Etoposide; Leukemia L1210; Mice; Novobiocin; Podophyllotoxin; Teniposide; Topoisomerase II Inhibitors

1988
Two specific topoisomerase II inhibitors prevent replication of human cytomegalovirus DNA: an implied role in replication of the viral genome.
    Journal of virology, 1988, Volume: 62, Issue:12

    Topics: Amsacrine; Cell Line; Cytomegalovirus; DNA Replication; DNA, Viral; Humans; Teniposide; Topoisomerase II Inhibitors; Virus Replication

1988
Induction of sister chromatid exchanges by inhibitors of topoisomerases.
    Cell biology and toxicology, 1986, Volume: 2, Issue:4

    Topics: Amsacrine; Animals; Camptothecin; Cells, Cultured; Cricetinae; DNA Topoisomerases, Type I; Enzyme Inhibitors; Fibroblasts; Podophyllotoxin; Sister Chromatid Exchange; Teniposide

1986
In vivo stimulation by antitumor drugs of the topoisomerase II induced cleavage sites in c-myc protooncogene.
    Biochemical and biophysical research communications, 1986, May-29, Volume: 137, Issue:1

    Topics: Aminoacridines; Amsacrine; Antineoplastic Agents; Cell Line; Chromosome Mapping; Deoxyribonuclease I; DNA Topoisomerases, Type II; DNA, Neoplasm; Ellipticines; Gene Amplification; Gene Expression Regulation; Genes; Humans; Intercalating Agents; Mutation; Proto-Oncogenes; Teniposide

1986
Role for topoisomerases in the release of DNA into the detergent-soluble fraction of eukaryotic cells.
    Proceedings of the National Academy of Sciences of the United States of America, 1986, Volume: 83, Issue:16

    Topics: Aminoacridines; Amsacrine; Animals; Camptothecin; Detergents; DNA; DNA Topoisomerases, Type I; Intercalating Agents; Kinetics; Mice; Novobiocin; Solubility; Spleen; Teniposide; Thymidine

1986
Effects of antileukemia agents on nuclear matrix-bound DNA replication in CCRF-CEM leukemia cells.
    Cancer research, 1988, Apr-01, Volume: 48, Issue:7

    Topics: Amsacrine; Antineoplastic Agents; Cell Nucleus; Chromatin; Cytarabine; DNA Replication; Hydroxyurea; Microscopy, Electron; Nuclear Proteins; Teniposide; Tumor Cells, Cultured

1988
Chemotherapy in metastatic retinoblastoma.
    Ophthalmic paediatrics and genetics, 1987, Volume: 8, Issue:1

    Topics: Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Child; Cisplatin; Cyclophosphamide; Eye Neoplasms; Humans; Retinoblastoma; Teniposide; Vincristine

1987
Single- and double-strand DNA breakage and repair in human lung adenocarcinoma cells exposed to etoposide and teniposide.
    Cancer research, 1985, Volume: 45, Issue:7

    Topics: Adenocarcinoma; Aminoacridines; Amsacrine; Cells, Cultured; DNA; DNA Repair; Etoposide; Humans; Lung Neoplasms; Podophyllotoxin; Teniposide

1985
Damage induced in episomal EBV DNA in Raji cells by antitumor drugs as measured by pulsed field gel electrophoresis.
    Analytical biochemistry, 1994, Volume: 220, Issue:1

    Topics: Amsacrine; Antineoplastic Agents; Bleomycin; Burkitt Lymphoma; Centrifugation, Density Gradient; DNA Damage; DNA, Viral; Electrophoresis, Gel, Pulsed-Field; Herpesvirus 4, Human; Plasmids; Teniposide; Tumor Cells, Cultured

1994
Analysis of eukaryotic topoisomerase II cleavage sites in the presence of the quinolone CP-115,953 reveals drug-dependent and -independent recognition elements.
    Molecular pharmacology, 1995, Volume: 48, Issue:2

    Topics: Amsacrine; Anti-Infective Agents; Base Sequence; DNA; DNA Topoisomerases, Type II; Etoposide; Fluoroquinolones; Humans; Hydrolysis; Molecular Sequence Data; Quinolones; Teniposide; Topoisomerase II Inhibitors

1995
DNA sequence preferences at sites cleaved by human DNA topoisomerase II in response to novel quinolone derivatives.
    Anti-cancer drug design, 1995, Volume: 10, Issue:3

    Topics: Amsacrine; Base Sequence; DNA; DNA Topoisomerases, Type II; HeLa Cells; Humans; Hydrolysis; Molecular Sequence Data; Quinolones; Substrate Specificity; Teniposide; Topoisomerase II Inhibitors

1995
DNA topoisomerases I & II cleavage sites in the type 1 human immunodeficiency virus (HIV-1) DNA promoter region.
    Biochemical and biophysical research communications, 1994, Dec-30, Volume: 205, Issue:3

    Topics: Amsacrine; Animals; Binding Sites; Camptothecin; Chromosome Mapping; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA, Viral; Genes, Viral; HIV Long Terminal Repeat; HIV-1; Humans; In Vitro Techniques; Mice; NF-kappa B; Promoter Regions, Genetic; Sp1 Transcription Factor; TATA Box; Teniposide

1994
Different topoisomerase II antitumor drugs direct similar specific long-range fragmentation of an amplified c-MYC gene locus in living cells and in high-salt-extracted nuclei.
    Proceedings of the National Academy of Sciences of the United States of America, 1995, Jan-03, Volume: 92, Issue:1

    Topics: Amsacrine; Antineoplastic Agents; Carcinoma, Small Cell; Cell Fractionation; Cell Line; Cell Nucleus; DNA Damage; DNA Topoisomerases, Type II; DNA, Neoplasm; Etoposide; Exons; Genes, myc; Humans; Lung Neoplasms; Restriction Mapping; Saline Solution, Hypertonic; Teniposide; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1995
Subcellular distribution of the alpha and beta topoisomerase II-DNA complexes stabilized by VM-26.
    Biochemical pharmacology, 1994, Nov-01, Volume: 48, Issue:9

    Topics: Amsacrine; Antigens, Neoplasm; Cell Nucleus; Deoxyribonuclease I; DNA; DNA Topoisomerases, Type II; DNA-Binding Proteins; Humans; Isoenzymes; Nuclear Matrix; Subcellular Fractions; Teniposide; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1994
Mechanistic studies of amsacrine-resistant derivatives of DNA topoisomerase II. Implications in resistance to multiple antitumor drugs targeting the enzyme.
    The Journal of biological chemistry, 1994, Aug-19, Volume: 269, Issue:33

    Topics: Adenosine Triphosphate; Amino Acid Sequence; Amsacrine; Biological Transport; DNA; DNA Topoisomerases, Type II; Drug Resistance; Hydrolysis; Molecular Sequence Data; Mutation; Saccharomyces cerevisiae; Sequence Deletion; Teniposide

1994
Different modes of cell-killing action between DNA topoisomerase I and II inhibitors revealed by kinetic analysis.
    Japanese journal of cancer research : Gann, 1994, Volume: 85, Issue:2

    Topics: Amsacrine; Antineoplastic Agents; Camptothecin; Carbazoles; Cell Cycle; Colonic Neoplasms; Diterpenes; DNA Replication; Dose-Response Relationship, Drug; Etoposide; Flow Cytometry; G2 Phase; Humans; Indoles; Mitosis; Quinones; S Phase; Teniposide; Time Factors; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Tumor Stem Cell Assay

1994
Effects of base mutations on topoisomerase II DNA cleavage stimulated by mAMSA in short DNA oligomers.
    Biochemistry, 1993, Jan-12, Volume: 32, Issue:1

    Topics: Amsacrine; Base Sequence; Binding Sites; DNA Topoisomerases, Type II; DNA, Viral; Kinetics; Molecular Sequence Data; Mutagenesis; Oligodeoxyribonucleotides; Simian virus 40; Substrate Specificity; Teniposide

1993
Topoisomerase II as a target of VM-26 and 4'-(9-acridinylamino)methanesulfon-m-aniside in atypical multidrug resistant human small cell lung carcinoma cells.
    Cancer research, 1993, Mar-01, Volume: 53, Issue:5

    Topics: Amsacrine; Carcinoma, Small Cell; DNA; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Drug Resistance; Humans; Lung Neoplasms; Teniposide; Tumor Cells, Cultured

1993
Apoptosis of S-phase HL-60 cells induced by DNA topoisomerase inhibitors: detection of DNA strand breaks by flow cytometry using the in situ nick translation assay.
    Toxicology letters, 1993, Volume: 67, Issue:1-3

    Topics: Amsacrine; Apoptosis; Camptothecin; DNA Damage; DNA, Neoplasm; Flow Cytometry; Genetic Techniques; Humans; S Phase; Teniposide; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1993
Similar sequence specificity of mitoxantrone and VM-26 stimulation of in vitro DNA cleavage by mammalian DNA topoisomerase II.
    Biochemistry, 1993, Mar-30, Volume: 32, Issue:12

    Topics: Amsacrine; Animals; Base Sequence; Binding Sites; DNA; DNA Topoisomerases, Type II; DNA, Viral; Electrophoresis, Agar Gel; Idarubicin; Leukemia P388; Mice; Mitoxantrone; Molecular Sequence Data; Mutagenesis; Oligodeoxyribonucleotides; Simian virus 40; Substrate Specificity; Teniposide; Tumor Cells, Cultured

1993
Response of purified mitochondrial DNA topoisomerase I from bovine liver to camptothecin and m-AMSA.
    Archives of biochemistry and biophysics, 1995, Dec-20, Volume: 324, Issue:2

    Topics: Amsacrine; Animals; Antineoplastic Agents; Camptothecin; Cattle; Cell Nucleus; DNA, Superhelical; Enzyme Inhibitors; Intercalating Agents; Mitochondria, Liver; Nucleic Acid Conformation; Plasmids; Teniposide; Topoisomerase I Inhibitors

1995
Position-specific effects of base mismatch on mammalian topoisomerase II DNA cleaving activity.
    Biochemistry, 1996, Jan-09, Volume: 35, Issue:1

    Topics: Amsacrine; Animals; Antineoplastic Agents; Base Composition; Base Sequence; DNA; DNA Topoisomerases, Type II; Humans; Idarubicin; Mammals; Mice; Molecular Sequence Data; Oligodeoxyribonucleotides; Recombinant Proteins; Substrate Specificity; Teniposide; Topoisomerase II Inhibitors

1996
Drug-specific sites of topoisomerase II DNA cleavage in Drosophila chromatin: heterogeneous localization and reversibility.
    Cancer research, 1996, Apr-15, Volume: 56, Issue:8

    Topics: Amsacrine; Animals; Base Sequence; Binding Sites; Cell Line; Chromatin; DNA; DNA Primers; DNA Topoisomerases, Type II; DNA, Satellite; Doxorubicin; Drosophila melanogaster; Enzyme Inhibitors; Genes, Insect; Histones; Kinetics; Molecular Sequence Data; Promoter Regions, Genetic; Substrate Specificity; Teniposide; Topoisomerase II Inhibitors

1996
Differential expression of DNA topoisomerase II alpha and -beta in P-gp and MRP-negative VM26, mAMSA and mitoxantrone-resistant sublines of the human SCLC cell line GLC4.
    British journal of cancer, 1996, Volume: 74, Issue:12

    Topics: Amsacrine; Antigens, Neoplasm; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Carcinoma, Small Cell; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA-Binding Proteins; Drug Resistance, Multiple; Humans; In Situ Hybridization, Fluorescence; Isoenzymes; Lung Neoplasms; Mitoxantrone; Multidrug Resistance-Associated Proteins; RNA, Messenger; RNA, Neoplasm; Teniposide; Tumor Cells, Cultured

1996
Improved targeting of brain tumors using dexrazoxane rescue of topoisomerase II combined with supralethal doses of etoposide and teniposide.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1998, Volume: 4, Issue:6

    Topics: Amsacrine; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Drug Administration Schedule; Etoposide; Female; Mice; Mice, Inbred Strains; Razoxane; Survival Rate; Teniposide; Topoisomerase II Inhibitors

1998
Cyclic AMP-dependent protein kinase type I is involved in hypersensitivity of human breast cells to topoisomerase II inhibitors.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1995, Volume: 1, Issue:1

    Topics: Amsacrine; Bleomycin; Breast Neoplasms; Cell Division; Cell Survival; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; DNA Topoisomerases, Type II; Etoposide; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genes, ras; Humans; Recombinant Proteins; Teniposide; Topoisomerase II Inhibitors; Transfection; Transforming Growth Factor alpha; Tumor Cells, Cultured

1995
Atp-bound topoisomerase ii as a target for antitumor drugs.
    The Journal of biological chemistry, 2001, May-11, Volume: 276, Issue:19

    Topics: Adenosine Triphosphate; Amino Acid Substitution; Amsacrine; Animals; Antineoplastic Agents; Cattle; DNA Topoisomerases, Type II; Doxorubicin; Etoposide; Kinetics; Mitoxantrone; Mutagenesis, Site-Directed; Recombinant Proteins; Teniposide; Thymus Gland

2001