arctiin has been researched along with lignans in 77 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (3.90) | 18.2507 |
| 2000's | 16 (20.78) | 29.6817 |
| 2010's | 49 (63.64) | 24.3611 |
| 2020's | 9 (11.69) | 2.80 |
| Authors | Studies |
|---|---|
| Fujimoto, T; Nishibe, S; Nose, M; Ogihara, Y; Takeda, T | 1 |
| Gao, H; Sha, ZF; Sun, WJ | 1 |
| Fujimoto, T; Nishibe, S; Nose, M; Ogihara, Y | 1 |
| Cho, SH; Choi, SW; Choi, Y; Rhee, SJ | 1 |
| Cai, SX; Fu, SQ; Xu, XY; Zheng, YM | 1 |
| Chen, H; Chen, Y; Ding, X; Liu, M; Lü, W; Zhang, Y | 1 |
| Hattori, M; Jin, JS | 1 |
| Hayashi, K; Hayashi, T; Nagaoka, Y; Narutaki, K; Uesato, S | 1 |
| Liu, H; Sun, S; Sun, Y; Wang, X; Wang, Y; Yu, A; Zhai, Y; Zhang, H; Zhang, Y | 1 |
| Joh, EH; Kim, DH; Lee, IA | 1 |
| Dou, DQ; Han, XY; He, F; Kang, TG; Pan, Q; Tan, RQ; Wang, J; Wang, W | 1 |
| Cai, SQ; Chen, HB; Shang, MY; Wang, RF; Wang, TM | 1 |
| Dou, DQ; Han, XY; Tan, RQ; Wang, W | 1 |
| Bian, D; Dai, Y; Dou, Y; Kong, L; Tong, B; Wei, Z; Wu, X; Xia, Y; Yang, Y; Ye, J | 1 |
| Bai, G; Cheng, B; Fang, R; Hou, W; Hou, Y; Jiang, M; Zhou, M | 1 |
| Cheng, X; Su, S; Wink, M | 1 |
| Cai, BC; Cai, H; Liu, QD; Qin, KM; Shen, BJ | 1 |
| Lü, H; Shan, H; Song, J; Sun, Z | 1 |
| Cui, X; Fang, ZZ; Wang, T; Wang, Y; Zhang, H; Zhao, Z | 1 |
| Hao, QH; Liu, MY; Wang, DM; Wang, XL; Wang, Y; Yu, F; Zhao, YK | 1 |
| Gao, Q; Yang, M; Zuo, Z | 1 |
| Dong, Z; Hu, J; Qin, K; Shi, Y; Si, X; Yang, B | 1 |
| Shimada, M; Suzuki, S; Umezawa, T | 1 |
| Awale, S; Esumi, H; Kadota, S; Kalauni, SK; Kurashima, Y; Lu, J; Tezuka, Y | 1 |
| Hu, Y; Huang, B; Liu, N; Wang, Y; Yang, Z; Zhu, Y | 1 |
| Hosono-Nishiyama, K; Matsumoto, T; Yamada, H | 1 |
| Hatayama, T; Ishihara, K; Konoshima, T; Saito, Y; Takasaki, M; Yamagishi, N | 1 |
| Han, XH; Hong, SS; Hwang, BY; Hwang, JS; Lee, D; Park, SY; Ro, JS | 1 |
| Deng, Y; Jia, W; Ma, L; Wang, X; Xu, Z; Zhang, H; Zhang, Y; Zhao, A; Zhou, M | 1 |
| Jiang, YY; Li, L; Li, ZM; Xiang, Y; Zhang, H; Zhang, WN; Zhang, ZH | 1 |
| Ahn, B; Chung, D; Han, SB; Hong, SS; Hwang, BY; Kim, BH; Kim, Y; Kwon, SW; Lee, CK; Lee, HY; Lee, IJ; Nam, SY; Song, S; Sung, H | 1 |
| Liu, K; Wang, L; Zhao, F | 2 |
| Feng, Y; Jia, W; Xu, Z; Yang, H; Zhou, M | 1 |
| Feng, TT; Han, J; Li, FY; Wang, GX; Zhu, B | 1 |
| Boldizsár, I; Borsodi, L; Füzfai, Z; Molnár-Perl, I; Sedlák, E; Tóth, F | 1 |
| De-Qiang, D; Fu-Rui, L; Gui-Rong, C; Hong-Fu, L; Li-Ping, C; Ning, J; Ting-Guo, K | 1 |
| Itokazu, Y; Iwasaki, H; Nago, M; Oku, H; Saitoh, S; Susanti, S; Taira, N | 1 |
| Cai, YZ; Lee, CK; Liu, J; Sze, SC; Tang, SC; Tong, Y; Wong, RN; Zhang, Y | 1 |
| Gu, Y; Hu, L; Ma, X; Qi, C; Sun, X; Yu, Q; Yuan, J; Zhang, H | 1 |
| Gu, Y; He, L; Hu, LH; Sun, XX; Yan, SS; Ye, JM; Yu, Q; Yuan, JY; Zhang, HH | 1 |
| Cai, ZZ; Ding, Y; Tao, JS; Yang, YS; Zhang, LY; Zhang, T | 1 |
| Fan, T; Feng Zhang, Y; Jiang, WL; Zhu, J | 1 |
| Inafuku, M; Iwasaki, H; Oku, H; Susanti, S; Taira, N | 1 |
| Bai, G; Fang, R; Jiang, M; Luo, G; Wang, Z; Wu, H; Yin, Y; Zhao, Z | 1 |
| Hao, QH; Li, M; Liu, MY; Liu, P; Wang, XL; Yu, XM | 1 |
| Feng, Y; Gu, C; Ju, J; Wang, K; Xu, Z | 1 |
| Fan, L; Geng, Y; Liu, F; Wang, M; Wang, X; Xi, X | 1 |
| Guan, YX; Lai, XQ; Pan, LH; Sun, CH; Yan, Y; Yao, JC; Zhang, L | 1 |
| Feng, ZM; Huang, XY; Jiang, JS; Yang, YN; Zhang, PC | 3 |
| Feng, Y; Gu, C; Ju, J; Ruan, K; Wang, H; Wang, K; Xu, Z | 1 |
| Su, S; Wink, M | 1 |
| Chang, CM; Chang, CZ; Kwan, AL; Lin, CL; Wu, SC | 1 |
| Feng, ZM; He, J; Huang, XY; Jiang, JS; Yang, YN; Zhang, PC | 1 |
| Chen, J; Chen, X; Fu, S; Gong, S; Guo, Y; He, Q; Jin, E; Li, W; Qian, Y; Yan, W; Yang, H; Ye, S | 1 |
| Bracht, A; Corrêa, RCG; Ferreira, ICFR; Haminiuk, CWI; Maciel, GM; Peralta, RM | 1 |
| Cao, W; Feng, T; Gu, X; Guo, Y; Li, J; Li, S; Liu, X; Liu, Y; Shen, W; Tsai, HI; Wu, F; Zhang, J; Zhang, L | 1 |
| Lou, C; Zhao, H; Zhao, Y; Zhu, R; Zhu, Z | 1 |
| Fang, SQ; Huang, J; Lu, XM; Shu, YH; Wang, YT; Wei, JX; Xiao, L | 1 |
| Cai, J; Fu, Q; Jin, Y; Liang, X; Liu, Y; Wang, F; Xin, H; Yang, B | 1 |
| Hong, SH; Kee, JY | 1 |
| Chen, JT; Chen, KY; Chen, YP; Ho, BY; Hsieh, MC; Hsu, AC; Hsu, RY; Lin, JA; Shen, TL; Tai, YT; Wang, GH; Wu, HT; Yao, HY | 1 |
| Esumi, H; Fujioka, R; Ikeda, M; Kishino, S; Mochizuki, N; Nomura, S; Owada, S; Sato, A; Tsuchihara, K; Yomoda, S | 1 |
| Cai, T; Fan, Q; He, Y; Huang, W; Shi, Z; Wen, Y; Xie, X | 1 |
| Cao, P; Gui, J; Han, J; Wang, G; Wang, X; Wang, Y; Zhang, J | 1 |
| Azeloglu, EU; Chen, Y; Das, B; Deng, Y; He, JC; Lee, K; Li, X; Liu, R; Ma, Y; Muwonge, AN; Wang, T; Wei, C; Wong, NJ; Yang, S; Zhang, W; Zhong, Y | 1 |
| Lee, KS; Lee, MG; Nam, KS | 1 |
| Gao, Y; Jin, T; Ruan, K; Wang, H; Wang, K; Wu, F; Xu, Z; Zhang, H; Zhang, J | 1 |
| Ohta, T; Okubo, S; Shoyama, Y; Uto, T | 1 |
| Cai, EB; Sun, BL; Wang, JY; Wang, Y; Yang, LM; Zhao, Y | 1 |
| Dong, X; Li, S; Lou, Z; Wang, D; Wang, G; Wu, Y; Yuan, Q; Zhou, X | 1 |
| Deng, H; Guo, HY; Huang, X; Jin, L; Quan, ZS; Shen, QK; Wu, D; Zhang, C | 1 |
| Mei, JW; Wang, HY; Xu, ZH; Zhang, JY | 1 |
| Chang, Y; Chen, S; Cui, Y; Fang, S; He, J; Jin, X; Li, J; Liu, S; Wang, L | 1 |
| Chen, Y; Jiang, H; Li, M; Lin, Z; Wang, Y; Xu, H; Xu, Z; Zhang, M; Zhu, J | 1 |
5 review(s) available for arctiin and lignans
| Article | Year |
|---|---|
Overview of the anti-inflammatory effects, pharmacokinetic properties and clinical efficacies of arctigenin and arctiin from Arctium lappa L.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Arctium; Cell Line, Tumor; Diabetic Nephropathies; Furans; Glucosides; Humans; Lignans; Neuroprotective Agents; Pancreatic Neoplasms | 2018 |
New phytochemicals as potential human anti-aging compounds: Reality, promise, and challenges.
Topics: Aging; Antioxidants; Arctium; Cell Line; Erythrocytes; Furans; Humans; Life Style; Lignans; Models, Animal; Phytochemicals; Plant Extracts; Randomized Controlled Trials as Topic; Seeds | 2018 |
Molecular mechanisms of the action of Arctigenin in cancer.
Topics: Animals; Antineoplastic Agents; Antioxidants; Arctium; Furans; Humans; Lignans; Neoplasms | 2018 |
A systematic review on botany, ethnopharmacology, quality control, phytochemistry, pharmacology and toxicity of Arctium lappa L. fruit.
Topics: Arctium; Botany; Ethnopharmacology; Fruit; Humans; Lignans; Pharyngitis; Phytochemicals; Quality Control | 2023 |
Effect of arctigenin on neurological diseases: A review.
Topics: Alzheimer Disease; Arctium; Furans; Humans; Lignans; Signal Transduction | 2023 |
1 trial(s) available for arctiin and lignans
| Article | Year |
|---|---|
Change in plasma lactate concentration during arctigenin administration in a phase I clinical trial in patients with gemcitabine-refractory pancreatic cancer.
Topics: Antineoplastic Agents, Phytogenic; Arctium; Area Under Curve; Biomarkers; Carcinoma, Adenosquamous; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Deoxycytidine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Furans; Gemcitabine; Gluconeogenesis; Humans; Kaplan-Meier Estimate; Kidney; Lactic Acid; Lignans; Liver; Mitochondria; Oxidative Phosphorylation; Pancreatic Neoplasms; Plant Extracts | 2018 |
71 other study(ies) available for arctiin and lignans
| Article | Year |
|---|---|
Structural transformation of lignan compounds in rat gastrointestinal tract.
Topics: 4-Butyrolactone; Animals; Biotransformation; Furans; Glucosides; Lignans; Lignin; Male; Plants, Medicinal; Rats; Rats, Wistar | 1992 |
Determination of arctiin and arctigenin in Fructus Arctii by reverse-phase HPLC.
Topics: Benzyl Compounds; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Furans; Glucosides; Lignans | 1992 |
Structural transformation of lignan compounds in rat gastrointestinal tract; II. Serum concentration of lignans and their metabolites.
Topics: 4-Butyrolactone; Animals; Digestive System; Drugs, Chinese Herbal; Furans; Glucosides; Lignans; Lignin; Male; Molecular Structure; Rats; Rats, Wistar | 1993 |
Effects of forsythia fruit extracts and lignan on lipid metabolism.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Cell Line, Tumor; Cholesterol, Dietary; Dietary Supplements; Forsythia; Furans; Glucosides; Humans; Lignans; Lipid Metabolism; Lipids; Male; Plant Extracts; Rats; Rats, Sprague-Dawley; Seeds | 2004 |
[Dyuamical studies on metabolic chemistry of lignans from seeds of Arctium lappa].
Topics: Animals; Arctium; Chromatography, High Pressure Liquid; Furans; Glucosides; Lignans; Liver; Male; Mice; Plants, Medicinal; Reproducibility of Results; Seeds; Tissue Distribution | 2005 |
Microemulsion electrokinetic chromatography for the separation of arctiin and arctigenin in Fructus Arctii and its herbal preparations.
Topics: Arctium; Borates; Chromatography, Micellar Electrokinetic Capillary; Drugs, Chinese Herbal; Emulsions; Furans; Glucosides; Hydrogen-Ion Concentration; Lignans; Reproducibility of Results | 2007 |
Further studies on a human intestinal bacterium Ruminococcus sp. END-1 for transformation of plant lignans to mammalian lignans.
Topics: Biotransformation; Butylene Glycols; Furans; Glucosides; Humans; Intestines; Lignans; Molecular Structure; Ruminococcus; Stereoisomerism | 2009 |
Therapeutic effect of arctiin and arctigenin in immunocompetent and immunocompromised mice infected with influenza A virus.
Topics: Animals; Antiviral Agents; Cells, Cultured; Dogs; Furans; Glucosides; Immunocompetence; Immunocompromised Host; Influenza A virus; Lignans; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred BALB C; Orthomyxoviridae Infections; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared | 2010 |
Determination of the major constituents in fruit of Arctium lappa L. by matrix solid-phase dispersion extraction coupled with HPLC separation and fluorescence detection.
Topics: Adsorption; Arctium; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Fruit; Furans; Glucosides; Lignans; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Spectrometry, Fluorescence | 2010 |
Arctigenin isolated from the seeds of Arctium lappa ameliorates memory deficits in mice.
Topics: Acetylcholinesterase; Animals; Arctium; Avoidance Learning; Cholinesterase Inhibitors; Drugs, Chinese Herbal; Functional Food; Furans; Glucosides; Lignans; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred ICR; Phytotherapy; Plant Extracts; Scopolamine; Seeds; Tacrine | 2011 |
Simultaneous determination of arctiin and its metabolites in rat urine and feces by HPLC.
Topics: 4-Butyrolactone; Animals; Arctium; Chromatography, High Pressure Liquid; Feces; Fruit; Furans; Glucosides; Lignans; Male; Plant Extracts; Rats, Sprague-Dawley | 2013 |
Alkyl and phenolic glycosides from Saussurea stella.
Topics: Animals; Anti-Inflammatory Agents; Coumaric Acids; Disaccharides; Female; Flavonoids; Furans; Glucosides; Glucuronidase; Glycosides; Hydroxybenzoates; Inflammation; Isoflavones; Lignans; Male; Molecular Structure; Neutrophils; Phytotherapy; Plant Extracts; Platelet Activating Factor; Quinic Acid; Rats, Wistar; Saussurea | 2013 |
[Determination of plasma protein binding rate of arctiin and arctigenin with ultrafiltration].
Topics: Animals; Binding, Competitive; Blood Proteins; Chromatography, High Pressure Liquid; Furans; Glucosides; Humans; Lignans; Male; Protein Binding; Rats; Rats, Sprague-Dawley; Ultrafiltration | 2013 |
Arctigenin but not arctiin acts as the major effective constituent of Arctium lappa L. fruit for attenuating colonic inflammatory response induced by dextran sulfate sodium in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arctium; Colitis; Dextran Sulfate; Dose-Response Relationship, Drug; Fruit; Furans; Glucosides; Lignans; Male; Mesalamine; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase Kinases; Molecular Structure; NF-kappa B; Oxidative Stress; Plant Extracts | 2014 |
Searching for synergistic bronchodilators and novel therapeutic regimens for chronic lung diseases from a traditional Chinese medicine, Qingfei Xiaoyan Wan.
Topics: Adrenergic beta-2 Receptor Agonists; Animals; Asthma; Bronchodilator Agents; Calcium; Cell Line; Chromatography, High Pressure Liquid; Chronic Disease; Disease Models, Animal; Drug Synergism; Drugs, Chinese Herbal; Ephedrine; Flavonoids; Furans; Glucosides; Guinea Pigs; Humans; Lactones; Lignans; Lung Diseases; Medicine, Chinese Traditional; Myocytes, Smooth Muscle; Trachea | 2014 |
Natural lignans from Arctium lappa modulate P-glycoprotein efflux function in multidrug resistant cancer cells.
Topics: 4-Butyrolactone; Antineoplastic Agents; Arctium; ATP Binding Cassette Transporter, Subfamily B; Benzofurans; Caco-2 Cells; Cell Line, Tumor; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Furans; Glucosides; Humans; Lignans; Molecular Structure; Rhodamine 123; Seeds | 2015 |
Optimization of the processing technology of Fructus Arctii by response surface methodology.
Topics: Arctium; Chemistry, Pharmaceutical; Chlorogenic Acid; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Furans; Glucosides; Hot Temperature; Lignans; Surface Properties; Technology, Pharmaceutical | 2015 |
Microwave-Assisted Extraction and Purification of Arctiin and Arctigenin from Fructus Arctii by High-Speed Countercurrent Chromatography.
Topics: Acetates; Arctium; Biphenyl Compounds; Chromatography, High Pressure Liquid; Countercurrent Distribution; Ethanol; Free Radical Scavengers; Furans; Glucosides; Hexanes; Hydrochloric Acid; Hydrolysis; Lignans; Liquid-Liquid Extraction; Microwaves; Picrates; Plant Extracts; Solvents; Water | 2016 |
Inhibition of UDP-Glucuronosyltransferase (UGT) Isoforms by Arctiin and Arctigenin.
Topics: Furans; Glucosides; Glucuronosyltransferase; Herb-Drug Interactions; Humans; Isoenzymes; Kinetics; Lignans | 2016 |
Isolation and Characterization of a Human Intestinal Bacterium Eggerthella sp. AUH-JLD49s for the Conversion of (-)-3'-Desmethylarctigenin.
Topics: Actinobacteria; Biotransformation; Cell Line, Tumor; Cell Proliferation; Feces; Female; Furans; Glucosides; Humans; Intestines; Lignans; Molecular Structure; Spectrometry, Mass, Electrospray Ionization | 2017 |
Changes in chemical components and antitumor activity during the heating process of Fructus Arctii.
Topics: Arctium; Cell Proliferation; Chlorogenic Acid; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Fruit; Furans; Glucosides; HL-60 Cells; Humans; Lignans; Medicine, Chinese Traditional; Quinic Acid | 2019 |
Stereochemical diversity in lignan biosynthesis of Arctium lappa L.
Topics: Arctium; Chromatography, High Pressure Liquid; Lignans; Molecular Conformation; Molecular Structure; Organ Specificity; Plant Structures; Stereoisomerism | 2002 |
Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation.
Topics: Animals; Antineoplastic Agents, Phytogenic; Arctium; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Screening Assays, Antitumor; Female; Furans; Glucose; Humans; Lignans; Liver Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Pancreatic Neoplasms; Phosphorylation; Proto-Oncogene Proteins c-akt; Xenograft Model Antitumor Assays | 2006 |
[Effect of anti-influenza virus of Arctigenin in vivo].
Topics: Animals; Antiviral Agents; Arctium; Drugs, Chinese Herbal; Female; Furans; Influenza A virus; Lignans; Lung; Male; Mice; Organ Size; Pneumonia, Viral; Ribavirin | 2005 |
Antiproliferative and apoptotic effects of butyrolactone lignans from Arctium lappa on leukemic cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Arctium; Cell Line, Tumor; Cell Proliferation; Fruit; Humans; Inhibitory Concentration 50; Lignans; Phytotherapy | 2006 |
Arctigenin from Fructus Arctii is a novel suppressor of heat shock response in mammalian cells.
Topics: Animals; Arctium; Cell Line, Tumor; Cell Survival; Cells, Cultured; DNA-Binding Proteins; Furans; Gene Expression Regulation; Heat Shock Transcription Factors; HeLa Cells; Hot Temperature; HSP70 Heat-Shock Proteins; Humans; Lignans; Mice; Temperature; Transcription Factors; Transcription, Genetic | 2006 |
Lignans from Arctium lappa and their inhibition of LPS-induced nitric oxide production.
Topics: Animals; Arctium; Cell Line; Lignans; Lipopolysaccharides; Mice; Nitric Oxide; Spectrum Analysis | 2007 |
The antidiabetic activity of total lignan from Fructus Arctii against alloxan-induced diabetes in mice and rats.
Topics: Alloxan; Animals; Arctium; Blood Glucose; Cholesterol, HDL; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Insulin; Lignans; Mice; Phytotherapy; Plant Extracts; Rats; Rats, Wistar | 2008 |
[A comparative research on quality of Vitmin C Yinqiao tablets from different manufacturers].
Topics: Arctium; Ascorbic Acid; Chlorogenic Acid; Chromatography, High Pressure Liquid; Drug Combinations; Drugs, Chinese Herbal; Furans; Lignans; Lonicera; Plants, Medicinal; Quality Control; Tablets | 2007 |
Diarctigenin, a lignan constituent from Arctium lappa, down-regulated zymosan-induced transcription of inflammatory genes through suppression of DNA binding ability of nuclear factor-kappaB in macrophages.
Topics: Animals; Anti-Inflammatory Agents; Arctium; Cells, Cultured; Cytokines; Dinoprostone; DNA; Female; Gene Expression Regulation; Interleukin-6; Lignans; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred C57BL; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Promoter Regions, Genetic; Signal Transduction; Tumor Necrosis Factor-alpha; Zymosan | 2008 |
[Induction of apoptosis of the human leukemia cells by arctigenin and its mechanism of action].
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Arctium; bcl-2-Associated X Protein; Caspase 3; Cell Proliferation; DNA Fragmentation; Fruit; Furans; HL-60 Cells; Humans; K562 Cells; Lignans; Plants, Medicinal; Proto-Oncogene Proteins c-bcl-2; Vascular Endothelial Growth Factor A | 2008 |
Inhibitory effect of total lignan from Fructus Arctii on aldose reductase.
Topics: Aldehyde Reductase; Animals; Arctium; Enzyme Inhibitors; Fruit; Lignans; Plant Extracts; Rats; Rats, Sprague-Dawley | 2010 |
In vitro anti-inflammatory effects of arctigenin, a lignan from Arctium lappa L., through inhibition on iNOS pathway.
Topics: Animals; Anti-Inflammatory Agents; Arctium; Cell Line; Cyclooxygenase 2; Furans; Humans; Interleukin-6; Lignans; Lipopolysaccharides; Macrophages; Mice; Molecular Structure; Monocytes; Nitric Oxide; Nitric Oxide Synthase Type II; Plant Extracts; Seeds; Tumor Necrosis Factor-alpha | 2009 |
Bioassay-guided isolation and identification of active compounds from Fructus Arctii against Dactylogyrus intermedius (Monogenea) in goldfish (Carassius auratus).
Topics: Animals; Anthelmintics; Arctium; Chemical Fractionation; Furans; Goldfish; Lethal Dose 50; Lignans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Plant Extracts; Platyhelminths; Spectroscopy, Fourier Transform Infrared; Survival Analysis | 2009 |
Mass fragmentation study of the trimethylsilyl derivatives of arctiin, matairesinoside, arctigenin, phylligenin, matairesinol, pinoresinol and methylarctigenin: their gas and liquid chromatographic analysis in plant extracts.
Topics: Arctium; Centaurea; Chromatography, High Pressure Liquid; Forsythia; Fruit; Gas Chromatography-Mass Spectrometry; Lignans; Molecular Weight; Plant Extracts | 2010 |
Synthesis of (-)-arctigenin derivatives and their anticancer activity.
Topics: Alkylation; Antineoplastic Agents; Arctium; Butylamines; Cell Line, Tumor; Cell Survival; Ethylamines; Fruit; Furans; Humans; Inhibitory Concentration 50; Lignans; Methylamines; Molecular Structure | 2012 |
Tumor specific cytotoxicity of arctigenin isolated from herbal plant Arctium lappa L.
Topics: Antineoplastic Agents; Apoptosis; Arctium; Cell Line, Tumor; Furans; Hep G2 Cells; Humans; Lignans; Plant Extracts | 2012 |
Comparative analysis of caffeoylquinic acids and lignans in roots and seeds among various burdock (Arctium lappa) genotypes with high antioxidant activity.
Topics: Antioxidants; Arctium; Genotype; Lignans; Plant Extracts; Plant Roots; Quinic Acid; Seeds | 2012 |
Arctigenin preferentially induces tumor cell death under glucose deprivation by inhibiting cellular energy metabolism.
Topics: Adenosine Triphosphate; Antineoplastic Agents, Phytogenic; Arctium; Cell Death; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Energy Metabolism; Furans; Glucose; Humans; Lignans; Mitochondria; Necrosis; Reactive Oxygen Species; Tumor Microenvironment | 2012 |
Arctigenin alleviates ER stress via activating AMPK.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Arctium; Endoplasmic Reticulum Stress; Enzyme Activation; Furans; Hep G2 Cells; Humans; Insulin-Secreting Cells; Lignans; Male; Palmitates; Protein Biosynthesis; Protein Kinases; Rats; Rats, Wistar; Signal Transduction; Unfolded Protein Response | 2012 |
[Research on the preparative method of Arctigenin].
Topics: Arctium; Flavonoids; Furans; Glucosides; Hydrogen-Ion Concentration; Hydrolysis; Lignans; Technology, Pharmaceutical; Temperature; Time Factors | 2012 |
Arctigenin protects focal cerebral ischemia-reperfusion rats through inhibiting neuroinflammation.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Arctium; Furans; Infarction, Middle Cerebral Artery; Inflammation; Interleukin-1beta; Lignans; Macrophages; Male; Microglia; Neuroprotective Agents; Phytotherapy; Rats; Rats, Sprague-Dawley; Seeds; Tumor Necrosis Factor-alpha | 2012 |
Mechanism of arctigenin-mediated specific cytotoxicity against human lung adenocarcinoma cell lines.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents, Phytogenic; Apoptosis; Arctium; Cell Cycle Proteins; Cell Line; Cyclin E; Cyclin-Dependent Kinase 2; Cyclins; Down-Regulation; Furans; Glutathione; Humans; Lignans; Lung Neoplasms; Nuclear Proteins; Oncogene Proteins; Phytotherapy; Plant Extracts; Proto-Oncogene Proteins c-akt; Signal Transduction | 2013 |
Arctigenin exhibits relaxation effect on bronchus by affecting transmembrane flow of calcium.
Topics: Animals; Arctium; Bronchi; Bronchodilator Agents; Calcium; Calcium Channels, L-Type; Cell Membrane; Female; Furans; Guinea Pigs; Ion Transport; Lignans; Male; Respiratory Tract Diseases | 2013 |
Study on human intestinal bacterium Blautia sp. AUH-JLD56 for the conversion of arctigenin to (-)-3'-desmethylarctigenin.
Topics: Arctium; Bacteria; Biotransformation; Fruit; Furans; Humans; Intestinal Mucosa; Intestines; Kinetics; Lignans; Plant Extracts | 2013 |
Evaluation of hypoglycemic activity of total lignans from Fructus Arctii in the spontaneously diabetic Goto-Kakizaki rats.
Topics: Animals; Arctium; Blood Glucose; C-Reactive Protein; Circadian Rhythm; Diabetes Mellitus; Drug Administration Schedule; Fruit; Gastric Inhibitory Polypeptide; Gene Expression Regulation; Glucagon-Like Peptide 1; Glucose Tolerance Test; Insulin; Lignans; Male; Rats; Rats, Wistar | 2014 |
Isolation and purification of arctigenin from Fructus Arctii by enzymatic hydrolysis combined with high-speed counter-current chromatography.
Topics: Arctium; beta-Glucosidase; Countercurrent Distribution; Fruit; Furans; Hydrolysis; Lignans | 2014 |
Inhibitory effect of arctigenin on lymphocyte activation stimulated with PMA/ionomycin.
Topics: Animals; Anti-Inflammatory Agents; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Arctium; Cell Cycle Checkpoints; Cell Proliferation; Cytokines; Female; Furans; Interferon-gamma; Interleukin-10; Interleukin-2; Interleukin-2 Receptor alpha Subunit; Interleukin-4; Interleukin-6; Ionomycin; Lectins, C-Type; Lignans; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Plants, Medicinal; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2014 |
Hepatoprotective activity of twelve novel 7'-hydroxy lignan glucosides from Arctii Fructus.
Topics: Apoptosis; Arctium; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Chemical and Drug Induced Liver Injury; Circular Dichroism; Drugs, Chinese Herbal; Fruit; Glucosides; Humans; Lignans; Liver Neoplasms; Magnetic Resonance Spectroscopy; Molecular Structure | 2014 |
Arctigenic acid, the key substance responsible for the hypoglycemic activity of Fructus Arctii.
Topics: Animals; Arctium; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Female; Fruit; Furans; Glucose; Glucose Tolerance Test; Glycated Hemoglobin; Hypoglycemic Agents; Lignans; Male; Mice, Inbred ICR; Molecular Structure; Rats; Rats, Wistar; Tandem Mass Spectrometry; Toxicity Tests, Acute | 2015 |
Four new neolignan glucosides from the fruits of Arctium lappa.
Topics: Arctium; Drugs, Chinese Herbal; Fruit; Glucosides; Lignans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oxotremorine; Stereoisomerism | 2015 |
Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans.
Topics: Aging; Animals; Animals, Genetically Modified; Antioxidants; Arctium; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Gene Expression Regulation; Green Fluorescent Proteins; Heat-Shock Proteins; Lignans; Longevity; Mitogen-Activated Protein Kinases; Oxidative Stress; Plants, Medicinal; Transcription Factors | 2015 |
New Butyrolactone Type Lignans from Arctii Fructus and Their Anti-inflammatory Activities.
Topics: Animals; Anti-Inflammatory Agents; Arctium; Drugs, Chinese Herbal; Fruit; Lactones; Lignans; Magnetic Resonance Spectroscopy; Mice; Microglia; Molecular Structure | 2015 |
Arctigenin, a Potent Ingredient of Arctium lappa L., Induces Endothelial Nitric Oxide Synthase and Attenuates Subarachnoid Hemorrhage-Induced Vasospasm through PI3K/Akt Pathway in a Rat Model.
Topics: Animals; Arctium; Cerebral Arteries; Furans; Humans; Lignans; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Subarachnoid Hemorrhage; Vasoconstriction; Vasospasm, Intracranial | 2015 |
Two new compounds from the fruits of Arctium lappa.
Topics: Algorithms; Antioxidants; Arctium; Ascorbic Acid; Drugs, Chinese Herbal; Fruit; Glycosides; Lignans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular | 2016 |
The antiviral activity of arctigenin in traditional Chinese medicine on porcine circovirus type 2.
Topics: Animals; Antiviral Agents; Arctium; Circoviridae Infections; Circovirus; Female; Furans; Injections, Intraperitoneal; Lignans; Medicine, Chinese Traditional; Mice; Mice, Inbred BALB C; Random Allocation; Swine; Swine Diseases | 2016 |
Arctigenin inhibits STAT3 and exhibits anticancer potential in human triple-negative breast cancer therapy.
Topics: Animals; Antineoplastic Agents; Apoptosis; Arctium; Asia, Eastern; Cell Line, Tumor; Cell Proliferation; DNA; Docetaxel; Drug Evaluation, Preclinical; Drug Synergism; Female; Fluorescent Antibody Technique; Furans; Humans; Hydrogen Bonding; Lignans; Mice, Nude; Molecular Docking Simulation; Plants, Medicinal; Protein Domains; Signal Transduction; STAT3 Transcription Factor; Taxoids; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays | 2017 |
Arctigenin, a lignan from Arctium lappa L., inhibits metastasis of human breast cancer cells through the downregulation of MMP-2/-9 and heparanase in MDA-MB-231 cells.
Topics: Animals; Arctium; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Chick Embryo; Down-Regulation; Female; Furans; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glucuronidase; Humans; Lignans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Metastasis | 2017 |
Protective effect of arctigenin on ethanol-induced neurotoxicity in PC12 cells.
Topics: Animals; Apoptosis; Arctium; Cell Cycle; Cell Proliferation; Cell Survival; Ethanol; Furans; Lignans; Neurons; Neuroprotective Agents; PC12 Cells; Rats | 2017 |
Purification of lignans from Fructus Arctii using off-line two-dimensional supercritical fluid chromatography/reversed-phase liquid chromatography.
Topics: Arctium; Chromatography, Reverse-Phase; Chromatography, Supercritical Fluid; Drugs, Chinese Herbal; Fruit; Lignans; Mass Spectrometry | 2017 |
Inhibition of Mast Cell-Mediated Allergic Responses by Arctii Fructus Extracts and Its Main Compound Arctigenin.
Topics: Anaphylaxis; Animals; Anti-Allergic Agents; Arctium; Furans; Humans; Interleukin-6; Interleukin-8; Lignans; Male; Mast Cells; Mice; Mice, Inbred ICR; Plant Extracts; Tumor Necrosis Factor-alpha | 2017 |
Arctigenin protects against steatosis in WRL68 hepatocytes through activation of phosphoinositide 3-kinase/protein kinase B and AMP-activated protein kinase pathways.
Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Arctium; Carnitine O-Palmitoyltransferase; Fatty Liver; Furans; Hep G2 Cells; Hepatocytes; Humans; Inflammation; Intercellular Adhesion Molecule-1; Interleukins; Lignans; Liver; Non-alcoholic Fatty Liver Disease; Oleic Acid; Oxidative Stress; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Phytotherapy; Plant Extracts; PPAR alpha; Proto-Oncogene Proteins c-akt; Signal Transduction; Sterol Regulatory Element Binding Protein 1 | 2018 |
Arctigenin ameliorates renal impairment and inhibits endoplasmic reticulum stress in diabetic db/db mice.
Topics: Animals; Apoptosis; Arctium; Cell Culture Techniques; Cell Line; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Endoplasmic Reticulum Stress; Epithelial Cells; Furans; Humans; Hypoglycemic Agents; Kidney; Lignans; Male; Mice, Inbred C57BL | 2019 |
Arctigenin attenuates diabetic kidney disease through the activation of PP2A in podocytes.
Topics: Animals; Arctium; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Progression; Furans; Humans; Lignans; Male; Mice; Mice, Knockout; Microscopy, Electron, Transmission; Nitric Oxide Synthase Type III; Podocytes; Protein Phosphatase 2; Streptozocin; Treatment Outcome | 2019 |
Anti‑metastatic effects of arctigenin are regulated by MAPK/AP‑1 signaling in 4T‑1 mouse breast cancer cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Arctium; Cell Line, Tumor; Cell Movement; Female; Furans; Humans; Lignans; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Neoplasm Invasiveness; Phosphorylation; Signal Transduction; Transcription Factor AP-1; Triple Negative Breast Neoplasms | 2020 |
The effect of total lignans from Fructus Arctii on Streptozotocin-induced diabetic retinopathy in Wistar rats.
Topics: Animals; Apoptosis; Arctium; Blood Glucose; Blood-Retinal Barrier; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Enzyme Activation; Fruit; Lignans; Male; Plant Extracts; Protein Kinase C beta; Rats, Wistar; Retina; Retinal Ganglion Cells; Signal Transduction; Streptozocin; Vascular Endothelial Growth Factor A | 2020 |
Arctigenin suppresses cell proliferation via autophagy inhibition in hepatocellular carcinoma cells.
Topics: Adenine; Apoptosis; Apoptosis Regulatory Proteins; Arctium; Autophagy; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Chloroquine; Forsythia; Furans; Hep G2 Cells; Humans; Lignans; Liver Neoplasms; Sequestosome-1 Protein | 2020 |
Arctigenin Triggers Apoptosis and Autophagy via PI3K/Akt/mTOR Inhibition in PC-3M Cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Arctium; Autophagy; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Furans; Humans; Lignans; Molecular Conformation; Phosphatidylinositol 3-Kinase; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; TOR Serine-Threonine Kinases; Tumor Cells, Cultured | 2021 |
Preventive effects of arctigenin from Arctium lappa L against LPS-induced neuroinflammation and cognitive impairments in mice.
Topics: Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Arctium; Aspartic Acid Endopeptidases; Cognitive Dysfunction; Furans; Inflammation; Lignans; Lipopolysaccharides; Memory Disorders; Mice; Microglia; Neuroinflammatory Diseases; NF-kappa B; Toll-Like Receptor 4 | 2022 |
Arctigenin: pharmacology, total synthesis, and progress in structure modification.
Topics: Anti-Inflammatory Agents; Arctium; Furans; Lignans | 2022 |
Chromatographic fingerprint combined with quantitative analysis of multi-components by single-marker for quality control of total lignans from Fructus arctii by high-performance liquid chromatography.
Topics: Arctium; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Fruit; Lignans; Quality Control | 2022 |