arctigenin has been researched along with lignans in 228 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (2.63) | 18.2507 |
| 2000's | 21 (9.21) | 29.6817 |
| 2010's | 151 (66.23) | 24.3611 |
| 2020's | 50 (21.93) | 2.80 |
| Authors | Studies |
|---|---|
| Gao, H; Sha, ZF; Sun, WJ | 1 |
| Hirano, T; Homma, M; Hosaka, K; Mitsuhashi, H; Naito, T; Oka, K | 1 |
| Doehmer, J; Gansser, D; Kasper, R | 1 |
| Eich, E; Fesen, MR; Kaloga, M; Mazumder, A; Pertz, H; Pommier, Y; Schulz, J | 1 |
| Miyamoto, K; Moritani, S; Nomura, M; Takeda, Y | 1 |
| Baik, KU; Cho, JY; Kim, AR; Park, MH; Yoo, ES | 1 |
| Chen, JX; Hajra, S; Ji, J; Liu, P; Sibi, MP | 1 |
| Choi, YH; Jang, YP; Kim, J; Kim, SG; Kim, SR; Kim, YC; Markelonis, GJ; Oh, TH | 1 |
| Fischer, J; Reynolds, AJ; Sharp, LA; Sherburn, MS | 1 |
| Cho, MK; Jang, YP; Kim, SG; Kim, YC | 1 |
| Cai, SX; Fu, SQ; Xu, XY; Zheng, YM | 1 |
| Awale, S; Esumi, H; Kadota, S; Kalauni, SK; Kurashima, Y; Lu, J; Tezuka, Y | 1 |
| Hu, Y; Huang, B; Liu, N; Wang, Y; Yang, Z; Zhu, Y | 1 |
| Ahn, MJ; Kim, CY; Kim, J | 1 |
| Hatayama, T; Ishihara, K; Konoshima, T; Saito, Y; Takasaki, M; Yamagishi, N | 1 |
| Akao, T; Hattori, M; Jin, JS; Kakiuchi, N; Nakamura, N; Zhao, YF | 1 |
| Ban, H; Deyama, T; Hirano, N; Inada, K; Kumagai, T; Mizoshita, T; Nishibe, S; Takasu, S; Takenaka, Y; Tanaka, H; Tatematsu, M; Toyoda, T; Tsukamoto, T; Utsunomiya, H | 1 |
| Benedettelli, S; Bosi, S; Carrasco-Pancorbo, A; Cortacero-Ramírez, S; Dinelli, G; Fernández-Gutiérrez, A; Ghiselli, L; Marotti, I; Segura-Carretero, A | 1 |
| Chen, H; Chen, Y; Ding, X; Liu, M; Lü, W; Zhang, Y | 1 |
| Batsuren, D; Kang, K; Kim, CY; Lee, HJ; Lee, SB; Nho, CW; Tunsag, J | 1 |
| Kang, HS; Kim, CJ; Lee, JY | 1 |
| Basu, A; Ghosh, J; Mishra, MK; Swarup, V | 1 |
| Jiang, YY; Li, L; Li, ZM; Xiang, Y; Zhang, H; Zhang, WN; Zhang, ZH | 1 |
| Chen, CY; Lin, RJ; Lo, WL | 1 |
| Liu, K; Wang, L; Zhao, F | 2 |
| Feng, TT; Han, J; Li, FY; Wang, GX; Zhu, B | 1 |
| Cha, MR; Hwang, JH; Hwang, YI; Kim, JY; Ko, B; Park, HR; Shin-ya, K; Son, ES; Song, SW; Tomida, A; Yoon, MY | 1 |
| Hayashi, K; Hayashi, T; Nagaoka, Y; Narutaki, K; Uesato, S | 1 |
| Kim, CJ; Lee, JY | 1 |
| Li, J; Nawaz, A; Sun, S; Wang, C; Wang, L; Wang, X; Wei, W; Yu, DH | 1 |
| Liu, H; Sun, S; Sun, Y; Wang, X; Wang, Y; Yu, A; Zhai, Y; Zhang, H; Zhang, Y | 1 |
| Joh, EH; Kim, DH; Lee, IA | 1 |
| Dai, W; Kou, X; Luo, L; Qi, S; Yin, Z | 1 |
| Liu, C; Luo, L; Yao, X; Yin, Z; Zhao, Z; Zhu, F | 1 |
| Hong, SC; Jeong, HJ; Jeong, JB; Koo, JS | 1 |
| Jho, EH; Kang, K; Kim, CY; Kim, M; Lee, HJ; Nho, CW; Yoo, JH | 1 |
| De-Qiang, D; Fu-Rui, L; Gui-Rong, C; Hong-Fu, L; Li-Ping, C; Ning, J; Ting-Guo, K | 1 |
| Chen, J; Hu, L; Jiang, H; Shen, X; Tang, X; Yu, L; Zhuang, J | 1 |
| Dai, YL; Feng, Y; Gong, J; Hu, F; Hu, YH; Huang, SL; Leng, Y; Tao, YD; Yu, RT | 1 |
| Itokazu, Y; Iwasaki, H; Nago, M; Oku, H; Saitoh, S; Susanti, S; Taira, N | 1 |
| Beguinot, F; Miele, C | 1 |
| Choi, JH; Choi, WS; Jeon, HS; Kim, AR; Kim, DK; Kim, HS; Kim, JH; Kim, JW; Kim, SN; Kim, YM; Lee, JM; Mun, SH | 1 |
| Dou, DQ; He, F; Hou, Q; Kang, TG; Sun, Y | 1 |
| Feng, S; Li, X; Liu, Y; Lv, X; Ma, J; Xiao, J; Yang, H; Yang, S; Zhang, Y | 1 |
| Chen, D; Liang, R; Liu, W; Mu, H; Sun, H; Sun, K; Tang, M; Wang, A; Yao, J; Zhao, F; Zhou, S | 1 |
| Gu, Y; Hu, L; Ma, X; Qi, C; Sun, X; Yu, Q; Yuan, J; Zhang, H | 1 |
| Gu, Y; He, L; Hu, LH; Sun, XX; Yan, SS; Ye, JM; Yu, Q; Yuan, JY; Zhang, HH | 1 |
| Li, G; Lü, C; Xu, H; Yao, X; Yin, Z | 1 |
| Cai, ZZ; Ding, Y; Tao, JS; Yang, YS; Zhang, LY; Zhang, T | 1 |
| Apostolides Arnold, N; Bruno, M; Caggia, S; Cardile, V; Formisano, C; Mari, A; Piacente, S; Rigano, D; Rosselli, S; Russo, A; Senatore, F | 1 |
| Fan, T; Feng Zhang, Y; Jiang, WL; Zhu, J | 1 |
| Benson, JD; Curtis, D; Lai, K; Schmitt, E; Selinger, DW; Serluca, FC; Solomon, JM; Wu, H | 1 |
| Awale, S; Dibwe, DF; Esumi, H; Kadota, S; Kawasaki, M; Kudou, N; Matsuya, Y; Miyoshi, C; Sugimoto, K; Taniguchi, A; Tezuka, Y; Toyooka, N | 1 |
| Hattori, M; Jin, JS; Lee, JH | 1 |
| Gu, W; Han, MJ; Hyam, SR; Jang, SE; Jeong, JJ; Kim, DH; Kim, KA; Lee, IA | 1 |
| Dou, DQ; Han, XY; He, F; Kang, TG; Pan, Q; Tan, RQ; Wang, J; Wang, W | 1 |
| Gao, Q; Wo, S; Zhang, Y; Zuo, Z | 3 |
| Gu, Y; Liu, C; Lu, R; Si, D; Zhang, T; Zhao, GR; Zou, Q | 1 |
| Dou, DQ; Han, XY; Tan, RQ; Wang, W | 1 |
| Chen, J; Chen, Y; Hu, L; Lei, M; Shen, S; Shen, X; Zhuang, J | 1 |
| Feng, D; Gu, Y; Laschke, MW; Menger, MD; Scheuer, C | 1 |
| Chen, TC; Gonzalez, R; Hofman, FM; Louie, SG; Pao, PW; Pirrung, MC; Schönthal, AH; Sharma, N; Thomas, S | 1 |
| Saif, MW; Strimpakos, AS | 1 |
| Fuchs, D; Gostner, JM; Kuehnl, S; Rollinger, JM; Schennach, H; Schroecksnadel, S; Schuster, D; Schwaiger, S; Stuppner, H; Temml, V | 1 |
| Bai, G; Cheng, BF; Dong, LY; Hou, YY; Jiang, M; Zhao, ZY | 1 |
| Chen, J; Chen, L; Hu, L; Jiang, H; Jiang, W; Li, C; Shen, X; Yan, J; Yao, XG; Zhu, Z | 1 |
| Chen, GR; Dou, DQ; Jiang, HS; Kang, TG; Li, FR; Li, HF; Xu, YB | 1 |
| Inafuku, M; Iwasaki, H; Oku, H; Susanti, S; Taira, N | 1 |
| Hao, H; Hu, Y; Kang, T; Liang, W; Ren, L; Sun, D; Wen, Q; Xia, Y; Yan, Y; Yang, J; Zhang, G; Zhang, N; Zhang, X; Zhao, D | 1 |
| Bai, G; Fang, R; Jiang, M; Luo, G; Wang, Z; Wu, H; Yin, Y; Zhao, Z | 1 |
| Huang, G; Huang, J; Li, Q; Pang, L; Shi, M; Sun, X; Wang, Y; Xu, X | 1 |
| Hsieh, CJ; Hsu, YC; Hsu, YL; Huang, YF; Kuo, PL; Tsai, EM | 1 |
| Hao, QH; Li, M; Liu, MY; Liu, P; Wang, XL; Yu, XM | 1 |
| Bai, G; Jiang, M; Lou, J; Luo, G; Wu, H; Yin, Y; Zhao, Z | 1 |
| Fan, L; Geng, Y; Liu, F; Wang, M; Wang, X; Xi, X | 1 |
| Jin, JJ; Wang, HQ; Wang, J | 1 |
| Dou, D; Jia, D; Kang, T; Li, D; Liu, Q; Wang, X | 1 |
| Esumi, H; Kadota, S; Kobayashi, Y; Li, F; Takahashi, N; Udagawa, N; Uehara, S; Yamashita, T | 1 |
| Awale, S; Dibwe, DF; Esumi, H; Kadota, S; Kato, M; Li, F; Miyoshi, C; Tezuka, Y | 1 |
| Chen, H; Chen, Z; Tian, Y; Wang, Z; Zhang, Y | 1 |
| Fu, XY; Huang, K; Li, LA; Meng, YG; Song, L; You, YQ | 1 |
| Guan, YX; Lai, XQ; Pan, LH; Sun, CH; Yan, Y; Yao, JC; Zhang, L | 1 |
| Shan, L; Shi, X; Sun, H; Xi, H; Zhou, D | 1 |
| Chen, J; Hu, LH; Shen, X; Sun, YY; Tang, X; Wu, RM; Zhou, TT; Zhu, ZY; Zhuang, JJ | 1 |
| Bian, D; Dai, Y; Dou, Y; Kong, L; Tong, B; Wei, Z; Wu, X; Xia, Y; Yang, Y; Ye, J | 1 |
| Chung, S; Gordon, D; Henning, SM; Phan, T; Vadgama, JV; Wang, P | 1 |
| Crouch, RA; Demeritte, T; Ogungbe, IV | 1 |
| Bai, G; Cheng, B; Fang, R; Hou, W; Hou, Y; Jiang, M; Zhou, M | 1 |
| Li, A; Wang, J; Wu, M; Zhang, H; Zhang, X | 1 |
| Gan, X; Hu, L; Lei, M; Yu, Q; Zhao, K | 1 |
| Cai, X; Chen, S; Du, J; Gao, Y; Liu, H; Yang, Y | 1 |
| He, BX; Jiang, ZK; Liu, XB; Zhang, WZ | 1 |
| Feng, Y; Gu, C; Ju, J; Ruan, K; Wang, H; Wang, K; Xu, Z | 1 |
| Cheng, X; Su, S; Wink, M | 2 |
| Cai, BC; Cai, H; Liu, QD; Qin, KM; Shen, BJ | 1 |
| Mu, S; Sun, L; Wang, X; Wei, L; Yu, Z | 1 |
| Cao, J; Cao, S; Hua, L; Lu, Z; Zhang, S; Zhou, H | 1 |
| Li, A; Pan, R; Wang, J; Wang, R; Zhang, X; Zhu, D | 1 |
| Bian, D; Dai, Y; Dou, Y; Luo, J; Tong, B; Wu, X; Xia, Y; Yang, Y | 1 |
| Feng, Q; Sun, BC; Xia, WK | 1 |
| Dai, Y; Dong, S; He, NN; Jiang, CJ; Xia, YF; Zeng, XY | 1 |
| Cai, L; Jiang, Q; Li, J; Song, S; Tong, R; Zang, Z; Zhang, S | 1 |
| Bai, G; Cheng, B; Cui, Q; Duan, X; Fang, R; Hou, Y; Liu, Y; Ma, X; Sun, J; Wang, W | 1 |
| Liu, FY; Pu, GR; Wang, B | 1 |
| Ge, GB; He, W; Hou, J; Wang, P; Xia, YL; Xin, H; Xu, W; Yang, L | 1 |
| Da, Y; Gu, C; Hao, J; Kong, Y; Li, W; Li, Y; Xue, Z; Yao, Z; Zhang, K; Zhang, L; Zhang, Q; Zhang, R; Zhang, Z | 1 |
| Cheng, Y; Wang, Y; Zhou, M | 1 |
| Chang, CM; Chang, CZ; Kwan, AL; Lin, CL; Wu, SC | 1 |
| Chen, H; Liu, Y; Sun, C; Wang, G; Yang, M; Yang, S; zhao, Y | 1 |
| Lü, H; Shan, H; Song, J; Sun, Z | 1 |
| Han, YH; Hong, SH; Jeon, YD; Jeong, MY; Jung, Y; Kang, J; Kee, JY; Kim, DS; Kim, HL; Kim, SJ; Lee, JH; Park, J; Park, R; Shin, S; So, HS; Um, JY; Youn, DH | 1 |
| Atlason, PT; Boldizsár, I; Borbély, S; Jócsák, G; Moldován, K; Molnár, E; Preininger, É; Sedlák, É; Tóth, A; Világi, I | 1 |
| Liu, M; Shang, J; Wang, YX; Xue, DT; Zhou, ZM | 1 |
| Cui, X; Fang, ZZ; Wang, T; Wang, Y; Zhang, H; Zhao, Z | 1 |
| Hu, L; Lei, M; Li, C; Shen, X; Xu, X; Yan, J; Zhu, Z | 1 |
| Chen, J; Chen, X; Fu, S; Gong, S; Guo, Y; He, Q; Jin, E; Li, W; Qian, Y; Yan, W; Yang, H; Ye, S | 1 |
| Cai, EB; Jia, CX; Li, W; Song, XZ; Yang, LM; Zhang, WY; Zhao, Y; Zheng, ML | 1 |
| Gao, Z; Kang, TG; Li, N; Li, SH; Meng, YK; Song, J; Wang, Y; Xia, Y; Yan, YH; Yang, JX; Zou, SF | 1 |
| Choi, BM; Han, YH; Hong, SH; Jeong, MY; Kee, JY; Kim, DS; Kim, HJ; Mun, JG; Park, SH; Park, SJ; Um, JY | 1 |
| Bracht, A; Corrêa, RCG; Ferreira, ICFR; Haminiuk, CWI; Maciel, GM; Peralta, RM | 1 |
| Cheng, KJ; Hu, CL; Hu, JF; Xiong, J; Xu, P; Yang, GX | 1 |
| Cai, E; Chen, Q; Han, M; Yang, L; Zhao, Y | 1 |
| Cao, W; Feng, T; Gu, X; Guo, Y; Li, J; Li, S; Liu, X; Liu, Y; Shen, W; Tsai, HI; Wu, F; Zhang, J; Zhang, L | 1 |
| Dai, Y; Luo, J; Tong, B; Wei, Z; Wu, X; Xia, Y; Yang, Y; Yuan, X; Yue, M | 1 |
| Lou, C; Zhao, H; Zhao, Y; Zhu, R; Zhu, Z | 1 |
| Brecht, K; Chibout, SD; Couttet, P; Krähenbühl, S; Paech, F; Pognan, F; Riebel, V; Uteng, M; Wolf, A | 1 |
| Chen, M; Ding, Y; Huang, X; Wang, Q | 1 |
| Chun, SY; Kim, S; Lee, KS; Maxwell, T; Nam, KS | 1 |
| Fang, SQ; Huang, J; Lu, XM; Shu, YH; Wang, YT; Wei, JX; Xiao, L | 1 |
| Imm, JY; Lee, J; Lee, SH | 1 |
| Bai, G; Chen, D; Cui, Q; Feng, X; Hou, Y; Jiang, M; Li, X; Liu, Y; Ma, X; Tao, J; Wang, Q; Wang, W; Wang, Y; Wang, Z | 1 |
| Cai, E; Gao, X; Guo, S; Han, M; Wang, Y; Xia, J; Yang, L; Zhao, Y | 1 |
| Cai, S; Gong, W; Liu, J; Ma, F; Qin, Y; Quan, Z; Tang, Z; Wang, S; Weng, M; Zhang, M; Zhou, D; Zuo, B | 1 |
| Hao, QH; Liu, MY; Wang, DM; Wang, XL; Wang, Y; Yu, F; Zhao, YK | 1 |
| Li, A; Li, P; Shu, M; Wang, J; Wang, R; Wang, Y; Wu, M; Zhang, J; Zhang, X | 1 |
| Huang, Q; Ji, J; Liu, P; Liu, X; Liu, Y; Ma, W; Qin, S; Sun, Z; Yuan, X; Zhang, J; Zhang, L; Zhang, Y | 1 |
| Alaj, R; Beretta, G; Cavolli, R; Daci, A; Krasniqi, S; Neziri, B; Norata, GD | 1 |
| Gaya, P; Landete, JM; Medina, M; Peirotén, Á; Sánchez-Jiménez, A | 1 |
| Akiyama, K; Kishida, T; Nishi, K; Nishiwaki, H; Ochi, Y; Sugahara, T; Wukirsari, T; Yamauchi, S | 1 |
| Che, F; Jiang, L; Lu, Y; Wang, H; Xie, Z; Zhang, S | 1 |
| Lee, SH; Lou, Z; Xu, Y | 1 |
| Hong, SH; Kee, JY | 1 |
| Baba, Y; Fujimuro, M; Hara, N; Ikeda, M; Moriguchi, M; Shigemi, Z; Watanabe, T | 1 |
| Yang, Y; Zhang, Y | 1 |
| Kim, S; Lee, KS; Maxwell, T; Nam, KS | 1 |
| Cai, E; Han, J; Han, M; Li, W; Song, X; Tu, S; Yang, L; Zhao, Y | 1 |
| Chen, JT; Chen, KY; Chen, YP; Ho, BY; Hsieh, MC; Hsu, AC; Hsu, RY; Lin, JA; Shen, TL; Tai, YT; Wang, GH; Wu, HT; Yao, HY | 1 |
| Cheng, X; Cheng, Y; Da, Y; Li, Y; Wang, D; Wang, H; Wang, Y; Xue, Z; Yang, F; Yang, J; Yang, L; Zhang, L; Zhang, Q; Zhang, R; Zhou, D | 1 |
| Chen, YL; Feng, G; Hai, Y; He, X; Li, LL; Li, W; Liu, CX; Wu, ZG; Wu, ZJ; Zhang, SC; Zheng, CQ | 1 |
| Gao, Q; Yang, M; Zuo, Z | 1 |
| Ding, CG; Ding, XM; Dou, M; Han, F; Tian, PX; Wang, YX; Xia, XX; Xue, WJ; Zheng, J | 1 |
| Esumi, H; Fujioka, R; Ikeda, M; Kishino, S; Mochizuki, N; Nomura, S; Owada, S; Sato, A; Tsuchihara, K; Yomoda, S | 1 |
| Chen, WC; Hu, Y; Liu, L; Shen, YF; Wang, GX; Zhu, B | 1 |
| Dai, J; Dong, G; Fang, R; Li, C; Li, Z; Ma, Q; Ming, J; Ning, Z; Shi, H; Si, C; Xiong, H; Yan, F; Zhang, H; Zhang, J | 1 |
| Cao, YJ; Jiang, YF; Jiang, ZA; Li, YJ; Liu, BY; Song, MC; Sun, JP; Wang, C; Wang, YF; Wang, ZH; Yang, J; Yang, R; Yin, HS | 1 |
| Feng, Q; Li, X; Lyu, J; Xia, W; Yang, J; Yao, J; Zhang, G; Zhao, N; Zhao, T; Zhou, G | 1 |
| Cai, T; Fan, Q; He, Y; Huang, W; Shi, Z; Wen, Y; Xie, X | 1 |
| Jin, C; Jin, CM; Quan, ZS; Shen, QK; Wang, H; Zhang, HB | 1 |
| Liang, T; Lu, Q; Nong, X; Wei, C; Wei, G; Zhao, J | 1 |
| Hu, Y; Li, B; Liu, L; Shen, Y; Wang, GX; Zhu, B | 1 |
| Béni, S; Boldizsár, I; Darcsi, A; Horvith, P; Komjáti, B; Könye, R; Moinir-Perl, I; Noszál, B; Ress, ÁE; Sólyomváry, A; Tóth, G | 1 |
| Chen, H; Du, Y; Gao, Y; Li, W; Li, Y; Shi, H; Velez de-la-Paz, OI; Wang, X; Yang, J; Yin, S; Yin, X | 1 |
| Cai, E; Dai, M; Han, M; Jia, X; Jiang, S; Shu, H; Sun, N; Yang, L | 1 |
| Hsieh, PL; Liao, YW; Lin, CY; Lu, MY; Peng, CY; Yu, CC | 1 |
| Hara, F; Kondo, Y; Naoe, A; Suzuki, T; Tsuchiya, T; Uga, N; Watanabe, S; Yasui, T | 1 |
| Hu, Y; Li, X; Liu, Y; Song, Y; Yang, R | 1 |
| Chen, L; Chen, X; Fang, J; Ke, N; Liu, Q; Pi, L | 1 |
| Cao, P; Gui, J; Han, J; Wang, G; Wang, X; Wang, Y; Zhang, J | 1 |
| Park, HR; Yoon, SB | 1 |
| Chen, WC; Hu, Y; Shen, YF; Wang, GX; Zhu, B | 1 |
| Dong, Z; Hu, J; Qin, K; Shi, Y; Si, X; Yang, B | 1 |
| Lina, L; Qian, Z; Suoni, L; Wang, Y; Xu, L; Yang, Z; Zhou, J | 1 |
| Azeloglu, EU; Chen, Y; Das, B; Deng, Y; He, JC; Lee, K; Li, X; Liu, R; Ma, Y; Muwonge, AN; Wang, T; Wei, C; Wong, NJ; Yang, S; Zhang, W; Zhong, Y | 1 |
| Dong, Q; Jin, G; Su, Y; Yan, X; Zhang, L; Zhao, X | 1 |
| Cao, J; Chen, F; Dai, W; Hong, L; Lu, Z; Zhang, S; Zhang, Y; Zhou, H | 1 |
| Huang, YS; Li, H; Li, Y; Lu, L; Ni, SH; Sun, SN; Wang, JJ; Wang, LJ; Xian, SX; Xiao, W; Yang, ZQ; Zhou, Z | 1 |
| Lan, M; Li, H; Liao, X; Tang, Z; Yang, C | 1 |
| Dai, Y; Fang, Y; Lv, C; Qiao, S; Tao, Y; Wei, Z; Xia, Y; Yue, M; Yun, X | 1 |
| Diaz, T; Elshimali, Y; Hao, Q; Henning, SM; Magyar, CE; Rettig, MB; Vadgama, JV; Verduzco, ADR; Wang, P; Zhong, J | 1 |
| Lee, KS; Lee, MG; Nam, KS | 2 |
| Huang, A; Ling, F; Qi, X; Tan, X; Tu, X; Wang, G | 1 |
| Huang, H; Liu, H; Shang, P; Tang, Q; Tang, S; Xu, J; Yang, S; Zhang, J; Zheng, X; Zhong, X; Zhou, W | 1 |
| An, H; Chen, Y; Guo, S; Shi, S; Wang, X; Zhan, Y; Zhang, H | 1 |
| Ohta, T; Okubo, S; Shoyama, Y; Uto, T | 1 |
| Kwon, YS; Lee, KS; Lee, MG; Nam, KS | 1 |
| Nishi, K; Nishimoto, A; Nishiwaki, H; Sugahara, T; Yamauchi, S | 1 |
| Aosai, F; Jin, X; Li, YB; Lu, YN; Ma, J; Piao, HN; Piao, J; Piao, LX; Shen, LX; Shi, SY; Xu, GH; Xu, X; Zhao, XD | 1 |
| Li, BY; Liu, TQ; Liu, YH; Shen, YF; Wang, GX | 1 |
| Liu, XP; Shao, TL; Shen, XB; Wang, GD; Yuan, PC; Zhu, L | 1 |
| Nam, GS; Nam, KS | 1 |
| Dai, Y; Lv, C; Miao, Y; Qiao, S; Sun, D; Tao, Y; Wei, Z; Xia, Y; Yun, X; Zhang, W; Zhu, Y | 1 |
| Dai, J; Dong, G; Fang, R; Fu, J; Guo, X; Li, C; Li, Z; Ma, Q; Ning, Z; Shi, H; Si, C; Xiong, H; Yan, F; Zhang, H; Zhang, J; Zhao, L | 1 |
| Aosai, F; Cheng, JH; Cui, YX; Jin, X; Li, J; Ma, J; Piao, HN; Piao, HR; Piao, LX; Xu, X; Zeng, XY | 1 |
| Fei, X; Hong, W; Jiang, Y; Liu, J; Liu, R | 1 |
| Deng, Y; Jiang, L; Li, W; Lu, Y | 1 |
| Awazuhara, T; Fujioka, R; Kishino, S; Nukui, Y; Ohno, K; Sato, M; Suzuki, Y; Terashima, T; Tsuchihara, K; Watanabe, K; Yoshida, A | 1 |
| Hu, Y; Shan, L; Wang, H | 1 |
| Cai, EB; Sun, BL; Wang, JY; Wang, Y; Yang, LM; Zhao, Y | 1 |
| Abbaszadeh, H; Mottaghi, S | 1 |
| Janthamala, S; Jusakul, A; Kimawaha, P; Klanrit, P; Kongpetch, S; Loilome, W; Namwat, N; Techasen, A | 1 |
| Chen, F; Huang, Q; Jiang, H; Liu, J; Long, F; Lv, L; Qin, T; Ren, L; Xie, Y; Zeng, M | 1 |
| Ding, R; Guo, C; Lan, B; Li, Y; Shen, H; Wei, L; Xue, Z; Yuan, S; Zhang, R | 1 |
| Abdelbasset, WK; Achmad, MH; Ahmadi, M; Bokov, DO; Ezzatifar, F; Hemmati, S; Jadidi-Niaragh, F; Mohammadi, H; Navashenaq, JG; Shabgah, AG; Soleimani, D; Suksatan, W | 1 |
| Fan, C; Feng, C; Li, H; Liu, M; Lu, H; Qi, Q; Su, H; Tang, W; Xiang, C; Xu, Y; Zhang, X; Zhou, Y | 1 |
| Abdel-Bakky, MS; Mohamadin, AM; Salama, SA | 1 |
| Bushko, R; Cao, M; Chen, X; Cox, A; Dunkin, D; Huang, W; Lazarski, C; Li, XM; Lin, A; Liu, C; Liu, Z; Maskey, A; Miao, M; Nowak-Wegrzyn, A; Song, Y; Srivastava, KD; Wang, L; Yang, N; Zambrano, L | 1 |
| Chen, J; Chen, R; Chen, X; He, B; Shao, Z; Wu, L; Yang, W; Zhou, D | 1 |
| Dong, G; Dong, Z; Jing, L; Liang, Y; Sun, M; Xiong, H; Yang, Y; Zhang, X; Zou, M | 1 |
| Li, BY; Qin, JC; Shen, YF; Wang, GX; Wang, T | 1 |
| Dai, Y; Fang, YL; Lv, CJ; Qiao, SM; Tao, Y; Wei, ZF; Xia, YF; Yue, MF; Yun, XM | 1 |
| Guo, R; Ji, Z; Li, H; Ma, Z | 1 |
| Dong, X; Li, S; Lou, Z; Wang, D; Wang, G; Wu, Y; Yuan, Q; Zhou, X | 1 |
| Guo, L; Li, X; Pu, S; Wang, X; Wang, Y; Wang, Z; Zhang, L | 1 |
| Deng, H; Guo, HY; Huang, X; Jin, L; Quan, ZS; Shen, QK; Wu, D; Zhang, C | 1 |
| Boldizsár, I; Borbély, S; Dobolyi, A; Jócsák, G; Koech, PK; Moldován, K; Varró, P; Világi, I | 1 |
| Chen, L; Ge, L; Liu, T; Wang, G; Zheng, Z | 1 |
| Barker, D; Leung, E; Paulin, EK; Pilkington, LI | 1 |
| Chang, Y; Chen, S; Cui, Y; Fang, S; He, J; Jin, X; Li, J; Liu, S; Wang, L | 1 |
| Hara, H; Hidaka, Y; Inamasu, S; Nakamura, S; Nishinaka, A; Shimazawa, M; Takajo, Y; Yomoda, S | 1 |
| Cheng, W; Han, J; Li, S; Miao, R; Wei, H; Yu, Y | 1 |
| Ahmed, AAM; El-Sayed, NM; Medras, ZJH; Mostafa, YM | 1 |
| Chen, Y; Jiang, H; Li, M; Lin, Z; Wang, Y; Xu, H; Xu, Z; Zhang, M; Zhu, J | 1 |
| Li, X; Shi, W; Tan, J; Wu, X; Xu, L; Zeng, W; Zhu, H | 1 |
9 review(s) available for arctigenin and lignans
| Article | Year |
|---|---|
Antioxidants: potential antiviral agents for Japanese encephalitis virus infection.
Topics: Animals; Antioxidants; Antiviral Agents; Astrocytes; Cell Death; Curcumin; Encephalitis Virus, Japanese; Encephalitis, Japanese; Fenofibrate; Furans; Humans; Lignans; Microglia; Minocycline; Neurons; Oxidative Stress | 2014 |
New phytochemicals as potential human anti-aging compounds: Reality, promise, and challenges.
Topics: Aging; Antioxidants; Arctium; Cell Line; Erythrocytes; Furans; Humans; Life Style; Lignans; Models, Animal; Phytochemicals; Plant Extracts; Randomized Controlled Trials as Topic; Seeds | 2018 |
Overview of the anti-inflammatory effects, pharmacokinetic properties and clinical efficacies of arctigenin and arctiin from Arctium lappa L.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Arctium; Cell Line, Tumor; Diabetic Nephropathies; Furans; Glucosides; Humans; Lignans; Neuroprotective Agents; Pancreatic Neoplasms | 2018 |
Molecular mechanisms of the action of Arctigenin in cancer.
Topics: Animals; Antineoplastic Agents; Antioxidants; Arctium; Furans; Humans; Lignans; Neoplasms | 2018 |
A comprehensive mechanistic insight into the dietary and estrogenic lignans, arctigenin and sesamin as potential anticarcinogenic and anticancer agents. Current status, challenges, and future perspectives.
Topics: Antineoplastic Agents; Cell Line, Tumor; Dioxoles; Furans; Humans; Lignans; Neoplasms | 2022 |
Arctigenin, an anti-tumor agent; a cutting-edge topic and up-to-the-minute approach in cancer treatment.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Disease Models, Animal; Drug Resistance, Neoplasm; Drugs, Chinese Herbal; Furans; Gene Expression Regulation, Neoplastic; Humans; Lignans; Neoplasms; Neovascularization, Pathologic; Signal Transduction; Xenograft Model Antitumor Assays | 2021 |
The therapeutic potential of arctigenin against multiple human diseases: A mechanistic review.
Topics: AMP-Activated Protein Kinases; Furans; Humans; Lignans; Neoplasms; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt | 2023 |
A systematic review on botany, ethnopharmacology, quality control, phytochemistry, pharmacology and toxicity of Arctium lappa L. fruit.
Topics: Arctium; Botany; Ethnopharmacology; Fruit; Humans; Lignans; Pharyngitis; Phytochemicals; Quality Control | 2023 |
Effect of arctigenin on neurological diseases: A review.
Topics: Alzheimer Disease; Arctium; Furans; Humans; Lignans; Signal Transduction | 2023 |
1 trial(s) available for arctigenin and lignans
| Article | Year |
|---|---|
Change in plasma lactate concentration during arctigenin administration in a phase I clinical trial in patients with gemcitabine-refractory pancreatic cancer.
Topics: Antineoplastic Agents, Phytogenic; Arctium; Area Under Curve; Biomarkers; Carcinoma, Adenosquamous; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Deoxycytidine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Furans; Gemcitabine; Gluconeogenesis; Humans; Kaplan-Meier Estimate; Kidney; Lactic Acid; Lignans; Liver; Mitochondria; Oxidative Phosphorylation; Pancreatic Neoplasms; Plant Extracts | 2018 |
218 other study(ies) available for arctigenin and lignans
| Article | Year |
|---|---|
Determination of arctiin and arctigenin in Fructus Arctii by reverse-phase HPLC.
Topics: Benzyl Compounds; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Furans; Glucosides; Lignans | 1992 |
Ion-sparing diuresis by 2,3-dibenzylbutane-1,4-diol, a synthetic mammalian-lignan derivative.
Topics: Animals; Benzyl Compounds; Chlorides; Diuretics; Furans; Furosemide; Ion Exchange; Lignans; Male; Mice; Mice, Inbred BALB C; Natriuresis; Potassium; Rats; Rats, Inbred Strains; Sodium | 1991 |
Biotransformation of the naturally occurring lignan (-)-arctigenin in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms.
Topics: Animals; Biotransformation; Cell Line; Cricetinae; Cricetulus; Cytochrome P-450 Enzyme System; Furans; Isoenzymes; Lignans; Molecular Structure; Rats; Recombinant Proteins; Transfection | 1994 |
(-)-Arctigenin as a lead structure for inhibitors of human immunodeficiency virus type-1 integrase.
Topics: 4-Butyrolactone; Antiviral Agents; Base Sequence; Binding Sites; DNA Nucleotidyltransferases; Enzyme Inhibitors; Furans; HIV-1; Humans; Integrases; Lactones; Lignans; Molecular Sequence Data; Molecular Structure; Structure-Activity Relationship | 1996 |
Cytotoxic components of bardanae fructus (goboshi).
Topics: Animals; Antineoplastic Agents, Phytogenic; Buthionine Sulfoximine; Cell Line; Drugs, Chinese Herbal; Furans; Humans; Lignans; Mice; Plant Extracts | 1996 |
Immunomodulatory effect of arctigenin, a lignan compound, on tumour necrosis factor-alpha and nitric oxide production, and lymphocyte proliferation.
Topics: Adjuvants, Immunologic; Animals; B-Lymphocytes; Cell Differentiation; Cell Division; Cell Survival; Cells, Cultured; Coloring Agents; Endotoxins; Escherichia coli; Furans; Lignans; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Nitric Oxide; Spleen; T-Lymphocytes; Tetrazolium Salts; Thiazoles; Tumor Necrosis Factor-alpha | 1999 |
Free-radical-mediated conjugate additions. Enantioselective synthesis of butyrolactone natural products: (-)-enterolactone, (-)-arctigenin, (-)-isoarctigenin, (-)-nephrosteranic acid, and (-)-roccellaric acid.
Topics: 4-Butyrolactone; Alkylation; Biological Products; Catalysis; Chemistry, Organic; Free Radicals; Fumarates; Furans; Lactones; Lignans; Magnetic Resonance Spectroscopy; Molecular Structure; Stereoisomerism; Succinates | 2002 |
Arctigenin protects cultured cortical neurons from glutamate-induced neurodegeneration by binding to kainate receptor.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Free Radical Scavengers; Furans; Glutamic Acid; Kainic Acid; Lignans; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Peroxides; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid | 2002 |
Radical carboxyarylation approach to lignans. Total synthesis of (-)-arctigenin, (-)-matairesinol, and related natural products.
Topics: Antineoplastic Agents; Antiviral Agents; Biological Products; Free Radicals; Furans; HL-60 Cells; Humans; Lignans; Molecular Structure; Stereoisomerism; Tetrahydronaphthalenes | 2004 |
Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits MAP kinases and AP-1 activation via potent MKK inhibition: the role in TNF-alpha inhibition.
Topics: Animals; Cell Line; Furans; Immunoblotting; Lignans; MAP Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinases; Phosphorylation; Transcription Factor AP-1; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2004 |
[Dyuamical studies on metabolic chemistry of lignans from seeds of Arctium lappa].
Topics: Animals; Arctium; Chromatography, High Pressure Liquid; Furans; Glucosides; Lignans; Liver; Male; Mice; Plants, Medicinal; Reproducibility of Results; Seeds; Tissue Distribution | 2005 |
Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation.
Topics: Animals; Antineoplastic Agents, Phytogenic; Arctium; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Screening Assays, Antitumor; Female; Furans; Glucose; Humans; Lignans; Liver Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Pancreatic Neoplasms; Phosphorylation; Proto-Oncogene Proteins c-akt; Xenograft Model Antitumor Assays | 2006 |
[Effect of anti-influenza virus of Arctigenin in vivo].
Topics: Animals; Antiviral Agents; Arctium; Drugs, Chinese Herbal; Female; Furans; Influenza A virus; Lignans; Lung; Male; Mice; Organ Size; Pneumonia, Viral; Ribavirin | 2005 |
A preparative isolation and purification of arctigenin and matairesinol from Forsythia koreana by centrifugal partition chromatography.
Topics: Chromatography, High Pressure Liquid; Countercurrent Distribution; Forsythia; Furans; Lignans; Molecular Structure; Plant Extracts; Solvents | 2006 |
Arctigenin from Fructus Arctii is a novel suppressor of heat shock response in mammalian cells.
Topics: Animals; Arctium; Cell Line, Tumor; Cell Survival; Cells, Cultured; DNA-Binding Proteins; Furans; Gene Expression Regulation; Heat Shock Transcription Factors; HeLa Cells; Hot Temperature; HSP70 Heat-Shock Proteins; Humans; Lignans; Mice; Temperature; Transcription Factors; Transcription, Genetic | 2006 |
Isolation and characterization of a human intestinal bacterium, Eubacterium sp. ARC-2, capable of demethylating arctigenin, in the essential metabolic process to enterolactone.
Topics: 4-Butyrolactone; Adenosine Triphosphate; Biotransformation; Eubacterium; Feces; Furans; Humans; Intestines; Lignans; Molecular Structure; Phylogeny; RNA, Bacterial; RNA, Ribosomal, 16S; Tetrahydrofolates; Time Factors | 2007 |
Inhibitory effect of nordihydroguaiaretic acid, a plant lignan, on Helicobacter pylori-associated gastric carcinogenesis in Mongolian gerbils.
Topics: Adenocarcinoma; Animals; Cell Division; Disease Models, Animal; Furans; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Lignans; Male; Masoprocol; Plants; Polymerase Chain Reaction; Specific Pathogen-Free Organisms; Stomach Neoplasms; Urease | 2007 |
Lignan profile in seeds of modern and old Italian soft wheat (Triticum aestivum L.) cultivars as revealed by CE-MS analyses.
Topics: 4-Butyrolactone; Benzodioxoles; Butylene Glycols; Dioxoles; Electrophoresis, Capillary; Furans; Italy; Lignans; Seeds; Tandem Mass Spectrometry; Triticum | 2007 |
Microemulsion electrokinetic chromatography for the separation of arctiin and arctigenin in Fructus Arctii and its herbal preparations.
Topics: Arctium; Borates; Chromatography, Micellar Electrokinetic Capillary; Drugs, Chinese Herbal; Emulsions; Furans; Glucosides; Hydrogen-Ion Concentration; Lignans; Reproducibility of Results | 2007 |
The chemopreventive effects of Saussurea salicifolia through induction of apoptosis and phase II detoxification enzyme.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cell Proliferation; Chromatin; DNA, Neoplasm; Enzyme Induction; Ethanol; Flow Cytometry; Furans; Humans; Lactones; Lignans; Metabolic Detoxication, Phase II; NAD(P)H Dehydrogenase (Quinone); Neoplasms; Plant Extracts; Saussurea; Sesquiterpenes; Solvents; Tetrazolium Salts; Thiazoles | 2007 |
Anti-inflammatory activity of arctigenin from Forsythiae Fructus.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents; Cell Line; Chromatography, Liquid; Eosinophil Peroxidase; Forsythia; Furans; Lignans; Macrophages; Mice; Peroxidase; Reactive Oxygen Species; Spectrum Analysis | 2008 |
Novel strategy for treatment of Japanese encephalitis using arctigenin, a plant lignan.
Topics: Animals; Cell Death; Encephalitis, Japanese; Female; Furans; Japanese Encephalitis Vaccines; Lignans; Male; Mice; Mice, Inbred BALB C; Phytotherapy | 2008 |
[A comparative research on quality of Vitmin C Yinqiao tablets from different manufacturers].
Topics: Arctium; Ascorbic Acid; Chlorogenic Acid; Chromatography, High Pressure Liquid; Drug Combinations; Drugs, Chinese Herbal; Furans; Lignans; Lonicera; Plants, Medicinal; Quality Control; Tablets | 2007 |
Cytotoxic activity of Ipomoea cairica.
Topics: 4-Butyrolactone; Antineoplastic Agents, Phytogenic; Benzoates; Cell Line, Tumor; Fatty Acids; Furans; Humans; Ipomoea; Lignans; Oleanolic Acid; Phytosterols; Plant Extracts | 2008 |
[Induction of apoptosis of the human leukemia cells by arctigenin and its mechanism of action].
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Arctium; bcl-2-Associated X Protein; Caspase 3; Cell Proliferation; DNA Fragmentation; Fruit; Furans; HL-60 Cells; Humans; K562 Cells; Lignans; Plants, Medicinal; Proto-Oncogene Proteins c-bcl-2; Vascular Endothelial Growth Factor A | 2008 |
In vitro anti-inflammatory effects of arctigenin, a lignan from Arctium lappa L., through inhibition on iNOS pathway.
Topics: Animals; Anti-Inflammatory Agents; Arctium; Cell Line; Cyclooxygenase 2; Furans; Humans; Interleukin-6; Lignans; Lipopolysaccharides; Macrophages; Mice; Molecular Structure; Monocytes; Nitric Oxide; Nitric Oxide Synthase Type II; Plant Extracts; Seeds; Tumor Necrosis Factor-alpha | 2009 |
Bioassay-guided isolation and identification of active compounds from Fructus Arctii against Dactylogyrus intermedius (Monogenea) in goldfish (Carassius auratus).
Topics: Animals; Anthelmintics; Arctium; Chemical Fractionation; Furans; Goldfish; Lethal Dose 50; Lignans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Plant Extracts; Platyhelminths; Spectroscopy, Fourier Transform Infrared; Survival Analysis | 2009 |
Arctigenin blocks the unfolded protein response and shows therapeutic antitumor activity.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Endoplasmic Reticulum Chaperone BiP; Furans; Gene Expression Regulation, Neoplastic; Glucose; HeLa Cells; HT29 Cells; Humans; Lignans; Mice; Mice, Nude; Time Factors; Tumor Burden; Unfolded Protein Response; Xenograft Model Antitumor Assays | 2010 |
Therapeutic effect of arctiin and arctigenin in immunocompetent and immunocompromised mice infected with influenza A virus.
Topics: Animals; Antiviral Agents; Cells, Cultured; Dogs; Furans; Glucosides; Immunocompetence; Immunocompromised Host; Influenza A virus; Lignans; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred BALB C; Orthomyxoviridae Infections; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared | 2010 |
Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits type I-IV allergic inflammation and pro-inflammatory enzymes.
Topics: Animals; Anti-Allergic Agents; Anti-Inflammatory Agents, Non-Steroidal; B-Lymphocytes; Enzyme Inhibitors; Furans; Guinea Pigs; Hemagglutination; Histamine Antagonists; Histamine Release; Hypersensitivity; Inflammation; Lignans; Lung; Male; Mast Cells; Mice; Mice, Inbred BALB C; Rats; Rats, Sprague-Dawley; Skin; T-Lymphocytes | 2010 |
Arctigenin suppresses unfolded protein response and sensitizes glucose deprivation-mediated cytotoxicity of cancer cells.
Topics: Activating Transcription Factor 4; Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Survival; DNA-Binding Proteins; Endoplasmic Reticulum Chaperone BiP; Furans; Gene Expression Regulation, Neoplastic; Glucose; HSP70 Heat-Shock Proteins; Humans; Lignans; Membrane Proteins; Regulatory Factor X Transcription Factors; Time Factors; Transcription Factors; Transcriptional Activation; Unfolded Protein Response; X-Box Binding Protein 1 | 2011 |
Determination of the major constituents in fruit of Arctium lappa L. by matrix solid-phase dispersion extraction coupled with HPLC separation and fluorescence detection.
Topics: Adsorption; Arctium; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Fruit; Furans; Glucosides; Lignans; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Spectrometry, Fluorescence | 2010 |
Arctigenin isolated from the seeds of Arctium lappa ameliorates memory deficits in mice.
Topics: Acetylcholinesterase; Animals; Arctium; Avoidance Learning; Cholinesterase Inhibitors; Drugs, Chinese Herbal; Functional Food; Furans; Glucosides; Lignans; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred ICR; Phytotherapy; Plant Extracts; Scopolamine; Seeds; Tacrine | 2011 |
Arctigenin inhibits lipopolysaccharide-induced iNOS expression in RAW264.7 cells through suppressing JAK-STAT signal pathway.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cell Survival; Chemokine CCL2; Cyclooxygenase 2; Drug Interactions; Furans; Interleukin-1beta; Interleukin-6; Janus Kinase 2; Lignans; Lipopolysaccharides; Macrophages; Membrane Proteins; Mice; Mitochondrial Proteins; Nitric Oxide Synthase Type II; Phosphorylation; Promoter Regions, Genetic; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor | 2011 |
Arctigenin enhances chemosensitivity of cancer cells to cisplatin through inhibition of the STAT3 signaling pathway.
Topics: Antineoplastic Agents; Apoptosis; Baculoviral IAP Repeat-Containing 3 Protein; Blotting, Western; Cell Line, Tumor; Cisplatin; Cyclin D1; Flow Cytometry; Furans; G1 Phase; HeLa Cells; Hep G2 Cells; Humans; Inhibitor of Apoptosis Proteins; Janus Kinase 1; Janus Kinase 2; Lignans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myeloid Cell Leukemia Sequence 1 Protein; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Signal Transduction; STAT3 Transcription Factor; Ubiquitin-Protein Ligases | 2011 |
Arctigenin induces cell cycle arrest by blocking the phosphorylation of Rb via the modulation of cell cycle regulatory proteins in human gastric cancer cells.
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Furans; Humans; Lignans; Phosphorylation; Plants; Proto-Oncogene Proteins c-bcl-2; Retinoblastoma Protein; Stomach Neoplasms | 2011 |
Cell and nuclear enlargement of SW480 cells induced by a plant lignan, arctigenin: evaluation of cellular DNA content using fluorescence microscopy and flow cytometry.
Topics: Antineoplastic Agents; Cell Division; Cell Line, Tumor; Cell Nucleus; Cell Nucleus Size; Cell Size; DNA; Flow Cytometry; Furans; G2 Phase; Humans; Lignans; Microscopy, Fluorescence; Saussurea | 2011 |
Synthesis of (-)-arctigenin derivatives and their anticancer activity.
Topics: Alkylation; Antineoplastic Agents; Arctium; Butylamines; Cell Line, Tumor; Cell Survival; Ethylamines; Fruit; Furans; Humans; Inhibitory Concentration 50; Lignans; Methylamines; Molecular Structure | 2012 |
Arctigenin efficiently enhanced sedentary mice treadmill endurance.
Topics: AMP-Activated Protein Kinases; Animals; Cell Line; Exercise Test; Fatty Acids; Furans; Gene Expression Regulation; Herbal Medicine; Lignans; Mice; Mitochondria; Muscles; Phosphorylation; Sedentary Behavior; Signal Transduction | 2011 |
Arctigenin, a natural compound, activates AMP-activated protein kinase via inhibition of mitochondria complex I and ameliorates metabolic disorders in ob/ob mice.
Topics: AMP-Activated Protein Kinases; Animals; Blood Glucose; Electron Transport Complex I; Furans; Glucose Metabolism Disorders; Lignans; Lipid Metabolism; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mice, Obese; Mitochondria, Muscle; Muscle, Skeletal; Rats; Rats, Sprague-Dawley | 2012 |
Tumor specific cytotoxicity of arctigenin isolated from herbal plant Arctium lappa L.
Topics: Antineoplastic Agents; Apoptosis; Arctium; Cell Line, Tumor; Furans; Hep G2 Cells; Humans; Lignans; Plant Extracts | 2012 |
New expectations from the well-known medicinal properties of Arctium lappa.
Topics: AMP-Activated Protein Kinases; Animals; Furans; Glucose Metabolism Disorders; Lignans; Male; Mitochondria, Muscle | 2012 |
Arctigenin suppresses receptor activator of nuclear factor κB ligand (RANKL)-mediated osteoclast differentiation in bone marrow-derived macrophages.
Topics: Animals; Biomarkers; Bone Marrow Cells; Bone Resorption; Cell Differentiation; Enzyme Activation; Furans; Gene Expression Regulation; Intracellular Signaling Peptides and Proteins; Lignans; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Osteoclasts; Protein-Tyrosine Kinases; RANK Ligand; Signal Transduction; Syk Kinase | 2012 |
Pharmacokinetic study of arctigenin in rat plasma and organ tissue by RP-HPLC method.
Topics: Animals; Chromatography, High Pressure Liquid; Furans; Lignans; Lung; Rats | 2013 |
Arctigenin anti-tumor activity in bladder cancer T24 cell line through induction of cell-cycle arrest and apoptosis.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Cycle Checkpoints; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Flow Cytometry; Furans; Humans; Lignans; Mitogen-Activated Protein Kinases; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 2012 |
pH and temperature dual-sensitive liposome gel based on novel cleavable mPEG-Hz-CHEMS polymeric vaginal delivery system.
Topics: Analysis of Variance; Calorimetry, Differential Scanning; Cell Survival; Cholesterol Esters; Furans; HEK293 Cells; Humans; Hydrazones; Hydrogen-Ion Concentration; Lignans; Liposomes; Nanoparticles; Phase Transition; Polyethylene Glycols; Temperature; Vaginal Creams, Foams, and Jellies | 2012 |
Arctigenin preferentially induces tumor cell death under glucose deprivation by inhibiting cellular energy metabolism.
Topics: Adenosine Triphosphate; Antineoplastic Agents, Phytogenic; Arctium; Cell Death; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Energy Metabolism; Furans; Glucose; Humans; Lignans; Mitochondria; Necrosis; Reactive Oxygen Species; Tumor Microenvironment | 2012 |
Arctigenin alleviates ER stress via activating AMPK.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Arctium; Endoplasmic Reticulum Stress; Enzyme Activation; Furans; Hep G2 Cells; Humans; Insulin-Secreting Cells; Lignans; Male; Palmitates; Protein Biosynthesis; Protein Kinases; Rats; Rats, Wistar; Signal Transduction; Unfolded Protein Response | 2012 |
Arctigenin promotes degradation of inducible nitric oxide synthase through CHIP-associated proteasome pathway and suppresses its enzyme activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Enzyme Activation; Furans; Humans; Lignans; Lipopolysaccharides; Macrophages; Mice; Nitric Oxide Synthase Type II; Phosphorylation; Proteasome Endopeptidase Complex; Proteolysis; Ubiquitin-Protein Ligases; Ubiquitination | 2012 |
[Research on the preparative method of Arctigenin].
Topics: Arctium; Flavonoids; Furans; Glucosides; Hydrogen-Ion Concentration; Hydrolysis; Lignans; Technology, Pharmaceutical; Temperature; Time Factors | 2012 |
Phytochemical profile and apoptotic activity of Onopordum cynarocephalum.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Proliferation; DNA Fragmentation; Dose-Response Relationship, Drug; Furans; HSP70 Heat-Shock Proteins; Humans; Inhibitory Concentration 50; Lignans; Molecular Structure; Monocyclic Sesquiterpenes; Onopordum; Plant Components, Aerial; Plant Extracts; Plants, Medicinal; PTEN Phosphohydrolase; Sesquiterpenes; Sesquiterpenes, Eudesmane | 2012 |
Arctigenin protects focal cerebral ischemia-reperfusion rats through inhibiting neuroinflammation.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Arctium; Furans; Infarction, Middle Cerebral Artery; Inflammation; Interleukin-1beta; Lignans; Macrophages; Male; Microglia; Neuroprotective Agents; Phytotherapy; Rats; Rats, Sprague-Dawley; Seeds; Tumor Necrosis Factor-alpha | 2012 |
Integrated compound profiling screens identify the mitochondrial electron transport chain as the molecular target of the natural products manassantin, sesquicillin, and arctigenin.
Topics: Animals; Dose-Response Relationship, Drug; Electron Transport Chain Complex Proteins; Furans; Gene Expression Profiling; Lignans; Mitochondrial Membranes; Molecular Structure; Naphthalenes; Zebrafish | 2013 |
Synthesis and antitumor evaluation of arctigenin derivatives based on antiausterity strategy.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Furans; Humans; Lignans; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Structure; Neoplasms, Experimental; Structure-Activity Relationship; Tumor Cells, Cultured | 2013 |
Ligand binding affinities of arctigenin and its demethylated metabolites to estrogen receptor alpha.
Topics: 4-Butyrolactone; Binding, Competitive; Estradiol; Estrogen Receptor alpha; Furans; Humans; Immobilized Proteins; Ligands; Lignans; Methylation; Phytoestrogens | 2013 |
Arctigenin ameliorates inflammation in vitro and in vivo by inhibiting the PI3K/AKT pathway and polarizing M1 macrophages to M2-like macrophages.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Cytokines; Furans; Lignans; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Peroxidase; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Trinitrobenzenesulfonic Acid | 2013 |
Simultaneous determination of arctiin and its metabolites in rat urine and feces by HPLC.
Topics: 4-Butyrolactone; Animals; Arctium; Chromatography, High Pressure Liquid; Feces; Fruit; Furans; Glucosides; Lignans; Male; Plant Extracts; Rats, Sprague-Dawley | 2013 |
Hydrolysis is the dominating in vivo metabolism pathway for arctigenin: identification of novel metabolites of arctigenin by LC/MS/MS after oral administration in rats.
Topics: Administration, Oral; Animals; Chromatography, Liquid; Furans; Hydrolysis; Kinetics; Lignans; Nuclear Magnetic Resonance, Biomolecular; Plasma; Rats; Tandem Mass Spectrometry | 2013 |
Development of an LC/MS/MS method in order to determine arctigenin in rat plasma: its application to a pharmacokinetic study.
Topics: Animals; Chromatography, Liquid; Drug Stability; Furans; Lignans; Limit of Detection; Rats; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2013 |
[Determination of plasma protein binding rate of arctiin and arctigenin with ultrafiltration].
Topics: Animals; Binding, Competitive; Blood Proteins; Chromatography, High Pressure Liquid; Furans; Glucosides; Humans; Lignans; Male; Protein Binding; Rats; Rats, Sprague-Dawley; Ultrafiltration | 2013 |
Synthesis and biological evaluation of arctigenin ester and ether derivatives as activators of AMPK.
Topics: AMP-Activated Protein Kinases; Animals; Cell Line; Esters; Furans; Lignans; Myoblasts; Phosphorylation; Structure-Activity Relationship | 2013 |
Inhibition of angiogenesis: a novel antitumor mechanism of the herbal compound arctigenin.
Topics: Angiogenesis Inhibitors; Angiogenic Proteins; Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Endothelial Cells; Furans; Humans; Immunohistochemistry; Lignans; Male; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Neovascularization, Pathologic; Neovascularization, Physiologic; Phytotherapy; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Signal Transduction; Spheroids, Cellular; Time Factors; Tissue Culture Techniques; Tumor Burden | 2013 |
Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I.
Topics: Adenosine Triphosphate; Biguanides; Cell Line, Tumor; Electron Transport; Electron Transport Chain Complex Proteins; Endoplasmic Reticulum Chaperone BiP; Furans; Heat-Shock Proteins; Humans; Immunoblotting; Lignans; Pyridines; Pyrones; Pyrvinium Compounds | 2013 |
Update on phase I studies in advanced pancreatic adenocarcinoma. Hunting in darkness?
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase I as Topic; Deoxycytidine; Furans; Gemcitabine; Humans; Hyaluronoglucosaminidase; Lignans; Mutation; Pancreatic Neoplasms; Polyethylene Glycols; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins; Recombinant Proteins; RNA Interference; Treatment Outcome | 2013 |
Lignans from Carthamus tinctorius suppress tryptophan breakdown via indoleamine 2,3-dioxygenase.
Topics: 4-Butyrolactone; Carthamus tinctorius; Cell Survival; Dose-Response Relationship, Drug; Furans; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Leukocytes, Mononuclear; Lignans; Molecular Structure; Neopterin; Plant Extracts; Plants, Medicinal; Seeds; Tryptophan | 2013 |
[Anti-inflammatory mechanism of qingfei xiaoyan wan studied with network pharmacology].
Topics: Animals; Anti-Inflammatory Agents; Asthma; Cell Line; Cholic Acid; Coumaric Acids; Cytokines; Drug Combinations; Drugs, Chinese Herbal; Epithelial Cells; Female; Furans; Guinea Pigs; Humans; Inflammation; Lignans; Lung; Male; MAP Kinase Signaling System; Random Allocation; Receptors, IgE; Toll-Like Receptors | 2013 |
Arctigenin effectively ameliorates memory impairment in Alzheimer's disease model mice targeting both β-amyloid production and clearance.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cells, Cultured; Disease Models, Animal; eIF-2 Kinase; Embryo, Mammalian; Eukaryotic Initiation Factor-2; Furans; Gene Expression Regulation; Humans; Lignans; Maze Learning; Memory Disorders; Mice; Mice, Transgenic; Mutation; Neurons; Presenilin-1; Signal Transduction; TOR Serine-Threonine Kinases | 2013 |
(-)-Arctigenin as a lead compound for anticancer agent.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Drug Discovery; Furans; Humans; Lignans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure | 2013 |
Mechanism of arctigenin-mediated specific cytotoxicity against human lung adenocarcinoma cell lines.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents, Phytogenic; Apoptosis; Arctium; Cell Cycle Proteins; Cell Line; Cyclin E; Cyclin-Dependent Kinase 2; Cyclins; Down-Regulation; Furans; Glutathione; Humans; Lignans; Lung Neoplasms; Nuclear Proteins; Oncogene Proteins; Phytotherapy; Plant Extracts; Proto-Oncogene Proteins c-akt; Signal Transduction | 2013 |
Neuroprotective effect of arctigenin via upregulation of P-CREB in mouse primary neurons and human SH-SY5Y neuroblastoma cells.
Topics: Animals; Cell Survival; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Furans; Humans; Lignans; Mice; Neuroblastoma; Neuroprotective Agents; Phosphorylation; Tumor Cells, Cultured | 2013 |
Arctigenin exhibits relaxation effect on bronchus by affecting transmembrane flow of calcium.
Topics: Animals; Arctium; Bronchi; Bronchodilator Agents; Calcium; Calcium Channels, L-Type; Cell Membrane; Female; Furans; Guinea Pigs; Ion Transport; Lignans; Male; Respiratory Tract Diseases | 2013 |
Arctigenin promotes cholesterol efflux from THP-1 macrophages through PPAR-γ/LXR-α signaling pathway.
Topics: Anticholesteremic Agents; Apolipoproteins E; ATP Binding Cassette Transporter 1; ATP Binding Cassette Transporter, Subfamily G, Member 1; ATP-Binding Cassette Transporters; Cell Line; Cholesterol; Furans; Humans; Lignans; Lipoproteins, LDL; Liver X Receptors; Macrophages; Orphan Nuclear Receptors; PPAR gamma; RNA, Small Interfering; Signal Transduction | 2013 |
Arctigenin, a dietary phytoestrogen, induces apoptosis of estrogen receptor-negative breast cancer cells through the ROS/p38 MAPK pathway and epigenetic regulation.
Topics: Activating Transcription Factor 2; Antioxidants; Apoptosis; Cell Line, Tumor; Epigenesis, Genetic; Ethylenediamines; Female; Furans; Gene Expression Regulation, Neoplastic; Histones; Humans; Lignans; Mammary Glands, Human; NADPH Oxidases; Organometallic Compounds; p38 Mitogen-Activated Protein Kinases; Phytoestrogens; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Receptors, Estrogen; Signal Transduction | 2014 |
Study on human intestinal bacterium Blautia sp. AUH-JLD56 for the conversion of arctigenin to (-)-3'-desmethylarctigenin.
Topics: Arctium; Bacteria; Biotransformation; Fruit; Furans; Humans; Intestinal Mucosa; Intestines; Kinetics; Lignans; Plant Extracts | 2013 |
Arctigenin, a potential anti-arrhythmic agent, inhibits aconitine-induced arrhythmia by regulating multi-ion channels.
Topics: Aconitine; Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Channels, L-Type; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Furans; Ion Channels; Lignans; Male; Myocytes, Cardiac; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Wistar; Sodium Channels | 2013 |
Isolation and purification of arctigenin from Fructus Arctii by enzymatic hydrolysis combined with high-speed counter-current chromatography.
Topics: Arctium; beta-Glucosidase; Countercurrent Distribution; Fruit; Furans; Hydrolysis; Lignans | 2014 |
Arctigenin enhances chemosensitivity to cisplatin in human nonsmall lung cancer H460 cells through downregulation of survivin expression.
Topics: Antineoplastic Agents; Base Sequence; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Line, Tumor; Cisplatin; DNA Primers; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Furans; Humans; Inhibitor of Apoptosis Proteins; Lignans; Lung Neoplasms; Polymerase Chain Reaction; Survivin | 2014 |
Protective effect of arctigenin against MPP+ and MPTP-induced neurotoxicity.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; bcl-2-Associated X Protein; Behavior, Animal; Brain; Cell Line, Tumor; Cell Survival; Dopamine; Furans; gamma-Aminobutyric Acid; Humans; Lignans; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; MPTP Poisoning; Neuroblastoma; Neuroprotective Agents; Neurotoxicity Syndromes; Parkinson Disease | 2014 |
Extensive intestinal first-pass metabolism of arctigenin: evidenced by simultaneous monitoring of both parent drug and its major metabolites.
Topics: Animals; Caco-2 Cells; Chromatography, High Pressure Liquid; Furans; Humans; Intestinal Absorption; Intestinal Mucosa; Lignans; Male; Permeability; Plasma; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2014 |
Arctigenin inhibits osteoclast differentiation and function by suppressing both calcineurin-dependent and osteoblastic cell-dependent NFATc1 pathways.
Topics: Animals; Calcineurin; Cell Differentiation; Cell Proliferation; Coculture Techniques; Furans; Humans; Lignans; Mice; NFATC Transcription Factors; Osteoblasts; Osteoclasts; Osteogenesis; Protein Transport; RANK Ligand; Signal Transduction; Transcription, Genetic | 2014 |
Antiausterity activity of arctigenin enantiomers: importance of (2R,3R)-absolute configuration.
Topics: Antineoplastic Agents, Phytogenic; Apocynaceae; Cell Line, Tumor; Drug Screening Assays, Antitumor; Furans; Humans; Lignans; Molecular Conformation; Stereoisomerism; Wikstroemia | 2014 |
Arctigenin promotes apoptosis in ovarian cancer cells via the iNOS/NO/STAT3/survivin signalling.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Caspase 3; Cell Line, Tumor; Female; Furans; Humans; Inhibitor of Apoptosis Proteins; Lignans; Nitric Oxide; Nitric Oxide Synthase Type II; Ovarian Neoplasms; Signal Transduction; STAT3 Transcription Factor; Survivin | 2014 |
Inhibitory effect of arctigenin on lymphocyte activation stimulated with PMA/ionomycin.
Topics: Animals; Anti-Inflammatory Agents; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Arctium; Cell Cycle Checkpoints; Cell Proliferation; Cytokines; Female; Furans; Interferon-gamma; Interleukin-10; Interleukin-2; Interleukin-2 Receptor alpha Subunit; Interleukin-4; Interleukin-6; Ionomycin; Lectins, C-Type; Lignans; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Plants, Medicinal; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2014 |
Arctigenin attenuates lipopolysaccharide-induced acute lung injury in rats.
Topics: Acute Lung Injury; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Down-Regulation; Enzyme Activation; Furans; I-kappa B Proteins; Interleukin-1beta; Interleukin-6; Lignans; Lipopolysaccharides; Lung; Male; Neutrophil Infiltration; NF-KappaB Inhibitor alpha; Peroxidase; Phosphorylation; Random Allocation; Rats; Rats, Sprague-Dawley; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2015 |
Arctigenin enhances swimming endurance of sedentary rats partially by regulation of antioxidant pathways.
Topics: AMP-Activated Protein Kinases; Animals; Antioxidants; Cell Line; Fatigue; Furans; Glutathione Peroxidase; Glutathione Reductase; Hydrogen Peroxide; Ion Channels; Lignans; Male; Mitochondria; Mitochondrial Proteins; Muscle, Skeletal; NF-E2-Related Factor 2; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Physical Conditioning, Animal; Physical Endurance; PPAR gamma; Rats; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase; Swimming; Thioredoxins; Transcription Factors; Tumor Suppressor Protein p53; Uncoupling Protein 2 | 2014 |
Elucidation of arctigenin pharmacokinetics after intravenous and oral administrations in rats: integration of in vitro and in vivo findings via semi-mechanistic pharmacokinetic modeling.
Topics: Administration, Oral; Animals; Bile; Biotransformation; Dose-Response Relationship, Drug; Furans; In Vitro Techniques; Injections, Intravenous; Intestinal Mucosa; Lignans; Liver; Male; Microsomes; Models, Biological; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2014 |
Arctigenin but not arctiin acts as the major effective constituent of Arctium lappa L. fruit for attenuating colonic inflammatory response induced by dextran sulfate sodium in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arctium; Colitis; Dextran Sulfate; Dose-Response Relationship, Drug; Fruit; Furans; Glucosides; Lignans; Male; Mesalamine; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase Kinases; Molecular Structure; NF-kappa B; Oxidative Stress; Plant Extracts | 2014 |
Arctigenin in combination with quercetin synergistically enhances the antiproliferative effect in prostate cancer cells.
Topics: Androgens; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Synergism; Furans; Humans; Lignans; Male; MicroRNAs; Phosphatidylinositol 3-Kinases; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Quercetin; Receptors, Androgen; Signal Transduction; STAT3 Transcription Factor | 2015 |
(-) Arctigenin and (+) pinoresinol are antagonists of the human thyroid hormone receptor β.
Topics: Furans; Humans; Hydrogen Bonding; Lignans; Molecular Docking Simulation; Protein Structure, Tertiary; Thyroid Hormone Receptors beta | 2014 |
Searching for synergistic bronchodilators and novel therapeutic regimens for chronic lung diseases from a traditional Chinese medicine, Qingfei Xiaoyan Wan.
Topics: Adrenergic beta-2 Receptor Agonists; Animals; Asthma; Bronchodilator Agents; Calcium; Cell Line; Chromatography, High Pressure Liquid; Chronic Disease; Disease Models, Animal; Drug Synergism; Drugs, Chinese Herbal; Ephedrine; Flavonoids; Furans; Glucosides; Guinea Pigs; Humans; Lactones; Lignans; Lung Diseases; Medicine, Chinese Traditional; Myocytes, Smooth Muscle; Trachea | 2014 |
The inhibition of activated hepatic stellate cells proliferation by arctigenin through G0/G1 phase cell cycle arrest: persistent p27(Kip1) induction by interfering with PI3K/Akt/FOXO3a signaling pathway.
Topics: 14-3-3 Proteins; Active Transport, Cell Nucleus; Becaplermin; Cell Line; Cell Nucleus; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Cyclin-Dependent Kinase Inhibitor p27; Down-Regulation; Forkhead Box Protein O3; Forkhead Transcription Factors; Furans; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Enzymologic; Gene Knockdown Techniques; Hepatic Stellate Cells; Humans; Lignans; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-sis; Resting Phase, Cell Cycle; RNA, Small Interfering; Signal Transduction | 2015 |
Synthesis and cytotoxicity evaluation of 4-amino-4-dehydroxylarctigenin derivatives in glucose-starved A549 tumor cells.
Topics: 4-Butyrolactone; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Furans; Glucose; Humans; Lignans; Structure-Activity Relationship | 2015 |
The effects of arctigenin on human rheumatoid arthritis fibroblast-like synoviocytes.
Topics: Adult; Apoptosis; Arthritis, Rheumatoid; Cell Proliferation; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Female; Fibroblasts; Furans; Humans; Lignans; Male; Middle Aged; Synovial Fluid; Synovial Membrane | 2015 |
Arctigenin Protects against Lipopolysaccharide-Induced Pulmonary Oxidative Stress and Inflammation in a Mouse Model via Suppression of MAPK, HO-1, and iNOS Signaling.
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Furans; Heme Oxygenase-1; Lignans; Lipopolysaccharides; Male; MAP Kinase Signaling System; Membrane Proteins; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Oxidative Stress; Protective Agents | 2015 |
Arctigenic acid, the key substance responsible for the hypoglycemic activity of Fructus Arctii.
Topics: Animals; Arctium; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Female; Fruit; Furans; Glucose; Glucose Tolerance Test; Glycated Hemoglobin; Hypoglycemic Agents; Lignans; Male; Mice, Inbred ICR; Molecular Structure; Rats; Rats, Wistar; Tandem Mass Spectrometry; Toxicity Tests, Acute | 2015 |
Natural lignans from Arctium lappa modulate P-glycoprotein efflux function in multidrug resistant cancer cells.
Topics: 4-Butyrolactone; Antineoplastic Agents; Arctium; ATP Binding Cassette Transporter, Subfamily B; Benzofurans; Caco-2 Cells; Cell Line, Tumor; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Furans; Glucosides; Humans; Lignans; Molecular Structure; Rhodamine 123; Seeds | 2015 |
Optimization of the processing technology of Fructus Arctii by response surface methodology.
Topics: Arctium; Chemistry, Pharmaceutical; Chlorogenic Acid; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Furans; Glucosides; Hot Temperature; Lignans; Surface Properties; Technology, Pharmaceutical | 2015 |
Ultra high performance liquid chromatography with electrospray ionization tandem mass spectrometry coupled with hierarchical cluster analysis to evaluate Wikstroemia indica (L.) C. A. Mey. from different geographical regions.
Topics: Apigenin; Chromatography, High Pressure Liquid; Cluster Analysis; Coumarins; Emodin; Flavones; Furans; Geography; Lignans; Medicine, Chinese Traditional; Plant Extracts; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Umbelliferones; Wikstroemia | 2015 |
Cytotoxicity of arctigenin and matairesinol against the T-cell lymphoma cell line CCRF-CEM.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 9; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Furans; Humans; Lignans; Lymphoma, T-Cell; Plant Extracts; Reactive Oxygen Species; S Phase | 2015 |
Mechanism of Arctigenin-Induced Specific Cytotoxicity against Human Hepatocellular Carcinoma Cell Lines: Hep G2 and SMMC7721.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Cell Line, Tumor; Cytochromes c; Fas Ligand Protein; fas Receptor; Furans; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Lignans; Membrane Potential, Mitochondrial; Mitochondria; NF-kappa B; Organ Specificity; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Tumor Necrosis Factor-alpha | 2015 |
Arctigenin suppresses transforming growth factor-β1-induced expression of monocyte chemoattractant protein-1 and the subsequent epithelial-mesenchymal transition through reactive oxygen species-dependent ERK/NF-κB signaling pathway in renal tubular epithe
Topics: Antigens, CD; Antioxidants; Cadherins; Cell Movement; Chemokine CCL2; Epithelial Cells; Epithelial-Mesenchymal Transition; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Furans; Gene Expression Regulation; Humans; Inflammation; Kidney Tubules; Lignans; Membrane Glycoproteins; Microscopy, Fluorescence; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidases; NF-kappa B; Reactive Oxygen Species; Signal Transduction; Transforming Growth Factor beta1; Zonula Occludens-1 Protein | 2015 |
Arctigenin exerts anti-colitis efficacy through inhibiting the differentiation of Th1 and Th17 cells via an mTORC1-dependent pathway.
Topics: Animals; Anti-Inflammatory Agents; Cell Differentiation; Colitis; Dextran Sulfate; Furans; Humans; Jurkat Cells; Lignans; Male; Mechanistic Target of Rapamycin Complex 1; Mice, Inbred C57BL; Multiprotein Complexes; Signal Transduction; Th1 Cells; Th17 Cells; TOR Serine-Threonine Kinases | 2015 |
[Protective effect of arctigenin in GK rats combined with hypertension macroangiopathy].
Topics: Animals; Blood Glucose; Blood Pressure; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Disease Models, Animal; Drugs, Chinese Herbal; Furans; Humans; Hypertension; Lignans; Male; Rats; Rats, Wistar | 2015 |
Comparative pharmacokinetics of arctigenin in normal and type 2 diabetic rats after oral and intravenous administration.
Topics: Administration, Intravenous; Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Diabetes Mellitus, Experimental; Furans; Intestinal Absorption; Lignans; Male; Molecular Structure; Rats; Rats, Sprague-Dawley | 2015 |
Integrated in silico and experimental methods revealed that Arctigenin inhibited angiogenesis and HCT116 cell migration and invasion through regulating the H1F4A and Wnt/β-catenin pathway.
Topics: Amino Acid Sequence; Animals; Animals, Genetically Modified; Cell Movement; Cell Proliferation; Computational Biology; Computer Simulation; Furans; HCT116 Cells; Histones; Human Umbilical Vein Endothelial Cells; Humans; Lignans; Molecular Sequence Data; Neoplasm Invasiveness; Neovascularization, Pathologic; Protein Interaction Maps; Proteomics; Wnt Signaling Pathway; Wound Healing; Zebrafish | 2015 |
PDK1/Akt/PDE4D axis identified as a target for asthma remedy synergistic with β2 AR agonists by a natural agent arctigenin.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Adrenergic beta-2 Receptor Agonists; Animals; Anti-Asthmatic Agents; Asthma; Blotting, Western; Bronchi; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Synergism; Furans; Guinea Pigs; Humans; Lignans; Myocytes, Smooth Muscle; Proto-Oncogene Proteins c-akt; Signal Transduction | 2015 |
[Suppression of VEGF protein expression by arctigenin in oral squamous cell carcinoma].
Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Down-Regulation; Furans; Humans; Immunohistochemistry; Lignans; Mice; Mice, Nude; Mouth Neoplasms; Neoplasm Transplantation; Vascular Endothelial Growth Factor A | 2015 |
Identification and characterization of human UDP-glucuronosyltransferases responsible for the in-vitro glucuronidation of arctigenin.
Topics: Biotransformation; Catalysis; Enzyme Inhibitors; Furans; Glucuronides; Glucuronosyltransferase; Humans; Intestinal Absorption; Intestines; Isoenzymes; Kinetics; Lignans; Liver; Microsomes, Liver; Minor Histocompatibility Antigens; Recombinant Proteins; Substrate Specificity; UDP-Glucuronosyltransferase 1A9 | 2015 |
Arctigenin Suppress Th17 Cells and Ameliorates Experimental Autoimmune Encephalomyelitis Through AMPK and PPAR-γ/ROR-γt Signaling.
Topics: Adenylate Kinase; Animals; Cell Differentiation; Cytokines; Encephalomyelitis, Autoimmune, Experimental; Female; Furans; Gene Expression Regulation; Lignans; Lymphoid Tissue; Mice, Inbred C57BL; Models, Biological; Nuclear Receptor Subfamily 1, Group F, Member 3; p38 Mitogen-Activated Protein Kinases; PPAR gamma; RNA, Messenger; Signal Transduction; Spinal Cord; Spleen; Th1 Cells; Th17 Cells | 2016 |
Arctigenin antagonizes mineralocorticoid receptor to inhibit the transcription of Na/K-ATPase.
Topics: Animals; Furans; Gene Expression Regulation; HEK293 Cells; Humans; Hypertension; Lignans; Mineralocorticoid Receptor Antagonists; Receptors, Mineralocorticoid; RNA, Messenger; Sodium-Potassium-Exchanging ATPase; Surface Plasmon Resonance; Transcriptional Activation | 2016 |
Arctigenin, a Potent Ingredient of Arctium lappa L., Induces Endothelial Nitric Oxide Synthase and Attenuates Subarachnoid Hemorrhage-Induced Vasospasm through PI3K/Akt Pathway in a Rat Model.
Topics: Animals; Arctium; Cerebral Arteries; Furans; Humans; Lignans; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Subarachnoid Hemorrhage; Vasoconstriction; Vasospasm, Intracranial | 2015 |
Arctigenin reduces blood pressure by modulation of nitric oxide synthase and NADPH oxidase expression in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Furans; Gene Expression Regulation, Enzymologic; Hypertension; Lignans; Male; NADPH Oxidases; Nitric Oxide Synthase; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley | 2015 |
Microwave-Assisted Extraction and Purification of Arctiin and Arctigenin from Fructus Arctii by High-Speed Countercurrent Chromatography.
Topics: Acetates; Arctium; Biphenyl Compounds; Chromatography, High Pressure Liquid; Countercurrent Distribution; Ethanol; Free Radical Scavengers; Furans; Glucosides; Hexanes; Hydrochloric Acid; Hydrolysis; Lignans; Liquid-Liquid Extraction; Microwaves; Picrates; Plant Extracts; Solvents; Water | 2016 |
Arctigenin Inhibits Adipogenesis by Inducing AMPK Activation and Reduces Weight Gain in High-Fat Diet-Induced Obese Mice.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; AMP-Activated Protein Kinases; Animals; Dietary Fats; Enzyme Activation; Furans; Humans; Lignans; Male; Mesenchymal Stem Cells; Mice; Obesity; Weight Loss | 2016 |
Arctigenin reduces neuronal responses in the somatosensory cortex via the inhibition of non-NMDA glutamate receptors.
Topics: Animals; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Furans; HEK293 Cells; Humans; Lignans; Male; Neurons; Organ Culture Techniques; Rats; Rats, Wistar; Receptors, Glutamate; Somatosensory Cortex | 2016 |
A novel arctigenin-containing latex glove prevents latex allergy by inhibiting type I/IV allergic reactions.
Topics: Animals; Anti-Allergic Agents; Biological Products; Cell Line; Cell Survival; Furans; Hypersensitivity; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Latex; Latex Hypersensitivity; Lignans; Lymphocytes; Mice; Mice, Inbred BALB C | 2016 |
Inhibition of UDP-Glucuronosyltransferase (UGT) Isoforms by Arctiin and Arctigenin.
Topics: Furans; Glucosides; Glucuronosyltransferase; Herb-Drug Interactions; Humans; Isoenzymes; Kinetics; Lignans | 2016 |
Synthesis and decreasing Aβ content evaluation of arctigenin-4-yl carbamate derivatives.
Topics: Amyloid beta-Peptides; Carbamates; Furans; HEK293 Cells; Humans; Lignans; Structure-Activity Relationship | 2016 |
The antiviral activity of arctigenin in traditional Chinese medicine on porcine circovirus type 2.
Topics: Animals; Antiviral Agents; Arctium; Circoviridae Infections; Circovirus; Female; Furans; Injections, Intraperitoneal; Lignans; Medicine, Chinese Traditional; Mice; Mice, Inbred BALB C; Random Allocation; Swine; Swine Diseases | 2016 |
The Synthesis and Evaluation of Arctigenin Amino Acid Ester Derivatives.
Topics: Amino Acids; Animals; Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Esters; Furans; Lignans; Mice; Molecular Structure; Neoplasms, Experimental; Structure-Activity Relationship | 2016 |
Arctigenin Confers Neuroprotection Against Mechanical Trauma Injury in Human Neuroblastoma SH-SY5Y Cells by Regulating miRNA-16 and miRNA-199a Expression to Alleviate Inflammation.
Topics: Anti-Inflammatory Agents; Apoptosis; Brain Injuries, Traumatic; Cell Line, Tumor; Furans; Humans; Lignans; MicroRNAs; Neurons; Neuroprotective Agents; NF-kappa B | 2016 |
Arctigenin Inhibits Lung Metastasis of Colorectal Cancer by Regulating Cell Viability and Metastatic Phenotypes.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Drug Screening Assays, Antitumor; Female; Furans; Lignans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Neoplasm Metastasis | 2016 |
Lignans from the shed trunk barks of the critically endangered plant Abies beshanzuensis and their anti-neuroinflammatory activities.
Topics: Abies; Animals; Anti-Inflammatory Agents; Cells, Cultured; Furans; Lignans; Mice; Microglia; Nitric Oxide; Plant Bark | 2017 |
Synthesis and pharmacological activity evaluation of arctigenin monoester derivatives.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cytokines; Dose-Response Relationship, Drug; Drug Design; Esters; Furans; Inflammation Mediators; Lignans; Liver Neoplasms, Experimental; Male; Mice, Inbred ICR; Molecular Structure; Nitrites; Structure-Activity Relationship; Tumor Burden | 2016 |
Arctigenin inhibits STAT3 and exhibits anticancer potential in human triple-negative breast cancer therapy.
Topics: Animals; Antineoplastic Agents; Apoptosis; Arctium; Asia, Eastern; Cell Line, Tumor; Cell Proliferation; DNA; Docetaxel; Drug Evaluation, Preclinical; Drug Synergism; Female; Fluorescent Antibody Technique; Furans; Humans; Hydrogen Bonding; Lignans; Mice, Nude; Molecular Docking Simulation; Plants, Medicinal; Protein Domains; Signal Transduction; STAT3 Transcription Factor; Taxoids; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays | 2017 |
Arctigenin functions as a selective agonist of estrogen receptor β to restrict mTORC1 activation and consequent Th17 differentiation.
Topics: Animals; Cell Differentiation; Colitis; Dextran Sulfate; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Estrogen Receptor Antagonists; Estrogen Receptor beta; Female; Furans; HSP90 Heat-Shock Proteins; Humans; Jurkat Cells; Lignans; Mechanistic Target of Rapamycin Complex 1; Mice, Inbred C57BL; Ovariectomy; Phosphorylation; Regulatory-Associated Protein of mTOR; Selective Estrogen Receptor Modulators; Signal Transduction; Th17 Cells; Time Factors; Transcription, Genetic | 2016 |
Arctigenin, a lignan from Arctium lappa L., inhibits metastasis of human breast cancer cells through the downregulation of MMP-2/-9 and heparanase in MDA-MB-231 cells.
Topics: Animals; Arctium; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Chick Embryo; Down-Regulation; Female; Furans; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glucuronidase; Humans; Lignans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Metastasis | 2017 |
Mechanistic insights into selective killing of OXPHOS-dependent cancer cells by arctigenin.
Topics: Adenosine Triphosphate; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Endoplasmic Reticulum Stress; Furans; Glycolysis; Humans; Lignans; Membrane Potential, Mitochondrial; Necrosis; Oxidative Phosphorylation; Oxygen Consumption | 2017 |
Arctigenin protects against neuronal hearing loss by promoting neural stem cell survival and differentiation.
Topics: Animals; Cell Survival; Cells, Cultured; Cochlea; Evoked Potentials, Auditory; Furans; Gentamicins; Hearing Loss; Lignans; Mechanotransduction, Cellular; Mice; Mice, Inbred BALB C; Neural Stem Cells; Neurogenesis; Neurons | 2017 |
The anti-metastatic effects of the phytoestrogen arctigenin on human breast cancer cell lines regardless of the status of ER expression.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Female; Furans; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Lignans; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Metastasis; Phytoestrogens; Receptors, Estrogen; Signal Transduction; Urokinase-Type Plasminogen Activator | 2017 |
Protective effect of arctigenin on ethanol-induced neurotoxicity in PC12 cells.
Topics: Animals; Apoptosis; Arctium; Cell Cycle; Cell Proliferation; Cell Survival; Ethanol; Furans; Lignans; Neurons; Neuroprotective Agents; PC12 Cells; Rats | 2017 |
β-Catenin Mediates Anti-adipogenic and Anticancer Effects of Arctigenin in Preadipocytes and Breast Cancer Cells.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Antineoplastic Agents; Apoptosis; Asteraceae; beta Catenin; Breast Neoplasms; CCAAT-Enhancer-Binding Protein-alpha; Female; Furans; Humans; Lignans; Lipid Metabolism; Mice; Plant Extracts; PPAR gamma; Signal Transduction | 2017 |
Biodistribution of arctigenin-loaded nanoparticles designed for multimodal imaging.
Topics: Animals; Cell Line; Drug Carriers; Fluorescent Dyes; Furans; Humans; Larva; Lignans; Male; Mice; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Multimodal Imaging; Nanoparticles; Particle Size; Polylysine; Tissue Distribution; Zebrafish | 2017 |
Synthesis and antitumour activity of arctigenin amino acid ester derivatives against H22 hepatocellular carcinoma.
Topics: Amino Acids; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Chemistry Techniques, Synthetic; Drug Screening Assays, Antitumor; Esters; Furans; Humans; Lignans; Liver Neoplasms; Mice, Inbred ICR; Nitrites; Solubility; Structure-Activity Relationship; Xenograft Model Antitumor Assays | 2018 |
Arctigenin induced gallbladder cancer senescence through modulating epidermal growth factor receptor pathway.
Topics: Adult; Aged; Animals; Apoptosis; Cell Proliferation; Cellular Senescence; ErbB Receptors; Female; Furans; Gallbladder Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Lignans; Male; MAP Kinase Signaling System; Mice; Middle Aged; RNA Interference; Xenograft Model Antitumor Assays | 2017 |
Isolation and Characterization of a Human Intestinal Bacterium Eggerthella sp. AUH-JLD49s for the Conversion of (-)-3'-Desmethylarctigenin.
Topics: Actinobacteria; Biotransformation; Cell Line, Tumor; Cell Proliferation; Feces; Female; Furans; Glucosides; Humans; Intestines; Lignans; Molecular Structure; Spectrometry, Mass, Electrospray Ionization | 2017 |
Arctigenin suppresses renal interstitial fibrosis in a rat model of obstructive nephropathy.
Topics: Animals; Chemokine CCL2; Disease Models, Animal; Epithelial-Mesenchymal Transition; Fibrosis; Furans; Kidney; Kidney Diseases; Lignans; Lipid Peroxidation; Male; NF-kappa B; Oxidative Stress; Rats, Sprague-Dawley; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Ureteral Obstruction | 2017 |
Arctigenin inhibits triple-negative breast cancers by targeting CIP2A to reactivate protein phosphatase 2A.
Topics: Antineoplastic Agents; Apoptosis; Autoantigens; Cell Line, Tumor; Down-Regulation; Furans; Humans; Intracellular Signaling Peptides and Proteins; Lignans; Membrane Proteins; Phosphorylation; Protein Phosphatase 2; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Small Interfering; Signal Transduction; STAT3 Transcription Factor; Triple Negative Breast Neoplasms | 2017 |
Arctigenin improves vascular tone and decreases inflammation in human saphenous vein.
Topics: Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Furans; Humans; Inflammation; Inflammation Mediators; Lignans; Saphenous Vein; Vascular Resistance; Vasodilation | 2017 |
Incomplete metabolism of phytoestrogens by gut microbiota from children under the age of three.
Topics: 4-Butyrolactone; Adult; Butylene Glycols; Case-Control Studies; Child, Preschool; Coumarins; Equol; Feces; Female; Furans; Gastrointestinal Microbiome; Humans; Hydrolyzable Tannins; Infant; Isoflavones; Lignans; Male; Phytoestrogens; Polyphenols | 2018 |
Syntheses of cytotoxic novel arctigenin derivatives bearing halogen and alkyl groups on aromatic rings.
Topics: Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Furans; Halogens; HeLa Cells; HL-60 Cells; Humans; Hydrocarbons, Aromatic; Lignans; Molecular Conformation; Structure-Activity Relationship | 2017 |
Arctigenin attenuates ischemic stroke via SIRT1-dependent inhibition of NLRP3 inflammasome.
Topics: Animals; Dose-Response Relationship, Drug; Down-Regulation; Encephalitis; Furans; Inflammasomes; Lignans; Male; Neuroprotective Agents; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Rats, Sprague-Dawley; Sirtuin 1; Stroke; Treatment Outcome | 2017 |
Arctigenin represses TGF-β-induced epithelial mesenchymal transition in human lung cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Asteraceae; beta Catenin; Cadherins; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Survival; Epithelial-Mesenchymal Transition; Furans; Humans; Lignans; Lung; Lung Neoplasms; Neoplasm Invasiveness; Phosphorylation; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta | 2017 |
Inhibition of Mast Cell-Mediated Allergic Responses by Arctii Fructus Extracts and Its Main Compound Arctigenin.
Topics: Anaphylaxis; Animals; Anti-Allergic Agents; Arctium; Furans; Humans; Interleukin-6; Interleukin-8; Lignans; Male; Mast Cells; Mice; Mice, Inbred ICR; Plant Extracts; Tumor Necrosis Factor-alpha | 2017 |
Arctigenin induces the apoptosis of primary effusion lymphoma cells under conditions of glucose deprivation.
Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Endoplasmic Reticulum Chaperone BiP; Furans; Glucose; Herpesviridae Infections; Herpesvirus 8, Human; Humans; Lignans; Lymphoma, Primary Effusion | 2018 |
Arctigenin exerts protective effects against myocardial infarction via regulation of iNOS, COX‑2, ERK1/2 and HO‑1 in rats.
Topics: Animals; Cyclooxygenase 2; Enzymes; Furans; Gene Expression Regulation; Heme Oxygenase-1; Lignans; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardial Infarction; Nitric Oxide Synthase Type II; Oxidative Stress; Protective Agents; Rats; Rats, Sprague-Dawley | 2018 |
Arctigenin inhibits the activation of the mTOR pathway, resulting in autophagic cell death and decreased ER expression in ER-positive human breast cancer cells.
Topics: Autophagy; Drug Synergism; Estrogen Receptor alpha; Female; Furans; Humans; Lignans; MCF-7 Cells; Phytoestrogens; Selective Estrogen Receptor Modulators; Signal Transduction; Tamoxifen; TOR Serine-Threonine Kinases | 2018 |
Experimental study of the anti-tumour activity and pharmacokinetics of arctigenin and its valine ester derivative.
Topics: Administration, Oral; Animals; Biological Availability; Cell Proliferation; Esters; Furans; Humans; Lignans; Mice; Mice, Inbred ICR; Neoplasms; Rats; Rats, Wistar; Solubility | 2018 |
Arctigenin protects against steatosis in WRL68 hepatocytes through activation of phosphoinositide 3-kinase/protein kinase B and AMP-activated protein kinase pathways.
Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Arctium; Carnitine O-Palmitoyltransferase; Fatty Liver; Furans; Hep G2 Cells; Hepatocytes; Humans; Inflammation; Intercellular Adhesion Molecule-1; Interleukins; Lignans; Liver; Non-alcoholic Fatty Liver Disease; Oleic Acid; Oxidative Stress; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Phytotherapy; Plant Extracts; PPAR alpha; Proto-Oncogene Proteins c-akt; Signal Transduction; Sterol Regulatory Element Binding Protein 1 | 2018 |
Arctigenin protects against liver injury from acute hepatitis by suppressing immune cells in mice.
Topics: Acute Disease; Animals; CD4-Positive T-Lymphocytes; Concanavalin A; Furans; Hepatitis; Inflammation; Inflammation Mediators; Interleukin-10; Lignans; Liver; Macrophages; Male; Mice; Mice, Inbred BALB C; Natural Killer T-Cells; Protective Agents; RAW 264.7 Cells | 2018 |
Exploring the Q-marker of "sweat soaking method" processed radix Wikstroemia indica: Based on the "effect-toxicity-chemicals" study.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; China; Chromatography, Liquid; Coumarins; Drugs, Chinese Herbal; Emodin; Furans; Humans; Lignans; Mass Spectrometry; Mice; Plant Extracts; Wikstroemia | 2018 |
Arctigenin: A two-edged sword in ischemia/reperfusion induced acute kidney injury.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Apoptosis; Disease Models, Animal; Dose-Response Relationship, Drug; Furans; Inflammation; Kidney; Lignans; Male; Mice, Inbred C57BL; Oxidative Stress; Reperfusion Injury | 2018 |
Synthesis and in vitro activities evaluation of arctigenin derivatives against spring viraemia of carp virus.
Topics: Animals; Antiviral Agents; Carps; Cell Line, Tumor; Drug Evaluation, Preclinical; Esters; Ethers; Furans; Lignans; Microbial Sensitivity Tests; Rhabdoviridae | 2018 |
Arctigenin Ameliorates Inflammation by Regulating Accumulation and Functional Activity of MDSCs in Endotoxin Shock.
Topics: Animals; Arginase; Furans; Inflammation; Interferon Regulatory Factors; Lignans; Lipopolysaccharides; Mice; MicroRNAs; Myeloid-Derived Suppressor Cells; Nitric Oxide Synthase Type II; RNA, Messenger; Shock, Septic | 2018 |
Arctigenin Attenuates Ischemia/Reperfusion Induced Ventricular Arrhythmias by Decreasing Oxidative Stress in Rats.
Topics: Animals; Arrhythmias, Cardiac; Disease Models, Animal; Furans; Glutathione Peroxidase; Lignans; Male; Malondialdehyde; Myocardial Infarction; Myocardium; NADPH Oxidase 1; NF-E2-Related Factor 2; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase; Thioredoxins | 2018 |
Quantitative Proteomic Analysis Reveals That Arctigenin Alleviates Concanavalin A-Induced Hepatitis Through Suppressing Immune System and Regulating Autophagy.
Topics: Animals; Apoptosis; Autophagy; Biomarkers; Concanavalin A; Cytokines; Disease Models, Animal; Female; Furans; Hepatitis; Immune System; Immunohistochemistry; Inflammation Mediators; Lignans; Mice; Proteomics | 2018 |
Synthesis and evaluation of novel arctigenin derivatives as potential anti-Toxoplasma gondii agents.
Topics: Animals; Antiparasitic Agents; Female; Furans; HeLa Cells; Humans; Lignans; Mice; Molecular Docking Simulation; Protein Kinases; Toxoplasma; Toxoplasmosis | 2018 |
Arctigenin inhibits RANKL-induced osteoclastogenesis and hydroxyapatite resorption in vitro and prevents titanium particle-induced bone loss in vivo.
Topics: Animals; Arthroplasty, Replacement; Bone Resorption; Cell Proliferation; Disease Models, Animal; Durapatite; Furans; Gene Expression Regulation, Developmental; Humans; Lignans; Mice; Osteoclasts; Osteogenesis; Osteolysis; Prostheses and Implants; RANK Ligand; Titanium; Transcription Factor RelA | 2019 |
Synthesis of arctigenin derivatives against infectious hematopoietic necrosis virus.
Topics: Animals; Antiviral Agents; Furans; Imidazoles; Infectious hematopoietic necrosis virus; Lignans; Rhabdoviridae Infections; Salmon; Structure-Activity Relationship; Virus Replication | 2019 |
Enzyme-hydrolyzed Fruit of Jurinea mollis: a Rich Source of (-)-(8R,8'R)-Arctigenin.
Topics: Asteraceae; Chromatography, High Pressure Liquid; Circular Dichroism; Fruit; Furans; Gas Chromatography-Mass Spectrometry; Hydrolysis; Lignans; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Plant Extracts | 2016 |
Repeated arctigenin treatment produces antidepressant- and anxiolytic-like effects in mice.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Depression; Disease Models, Animal; Furans; Lignans; Male; Mice; Mice, Inbred ICR; Motor Activity; Ribonuclease, Pancreatic; Stress, Psychological; Thrombopoietin; Vascular Endothelial Growth Factor A | 2019 |
The effects of Arctigenin-Valine ester on chemotherapy-induced myelosuppression in mice.
Topics: Animals; Antineoplastic Agents; Bone Marrow Cells; Cell Cycle Checkpoints; Cytokines; Furans; Hematopoietic Stem Cells; Lignans; Male; Mice; Mice, Inbred BALB C; Neoplasms; Valine | 2019 |
Arctigenin Reduces Myofibroblast Activities in Oral Submucous Fibrosis by LINC00974 Inhibition.
Topics: Areca; Arecoline; Cell Movement; Cell Transdifferentiation; Furans; Gene Expression Regulation; Humans; Lignans; Mouth Mucosa; Myofibroblasts; Oral Submucous Fibrosis; Smad2 Protein; Transforming Growth Factor beta | 2019 |
Arctigenin induces apoptosis in human hepatoblastoma cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cells, Cultured; Furans; Hepatoblastoma; Humans; Lignans; Liver Neoplasms | 2019 |
Arctigenin improves lipid metabolism by regulating AMP-activated protein kinase and downstream signaling pathways.
Topics: 3T3-L1 Cells; Acetyl-CoA Carboxylase; Adipocytes; AMP-Activated Protein Kinases; Animals; Cell Survival; Fatty Acid Synthase, Type I; Furans; Lignans; Lipid Metabolism; Lipoprotein Lipase; Male; Mice; PPAR gamma; Rats; Sterol Regulatory Element Binding Protein 1 | 2019 |
The antitumor function of arctigenin in human retinoblastoma cells is mediated by jagged‑1.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Furans; Humans; Jagged-1 Protein; Lignans; Receptors, Notch; Retinoblastoma; Signal Transduction | 2019 |
Arctigenin ameliorates renal impairment and inhibits endoplasmic reticulum stress in diabetic db/db mice.
Topics: Animals; Apoptosis; Arctium; Cell Culture Techniques; Cell Line; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Endoplasmic Reticulum Stress; Epithelial Cells; Furans; Humans; Hypoglycemic Agents; Kidney; Lignans; Male; Mice, Inbred C57BL | 2019 |
Arctigenin Inhibits Etoposide Resistance in HT-29 Colon Cancer Cells during Microenvironmental Stress.
Topics: Antineoplastic Agents; Apoptosis; Cell Survival; Colonic Neoplasms; Colony-Forming Units Assay; DNA Topoisomerases, Type II; Drug Resistance, Neoplasm; Endoplasmic Reticulum Chaperone BiP; Etoposide; Furans; Heat-Shock Proteins; HT29 Cells; Humans; Lignans; Stress, Physiological; Tumor Microenvironment | 2019 |
Synthesis and antiviral activity of a new arctigenin derivative against IHNV in vitro and in vivo.
Topics: Animals; Antiviral Agents; Cell Line, Tumor; Drug Evaluation, Preclinical; Fish Diseases; Furans; Infectious hematopoietic necrosis virus; Lignans; Microbial Sensitivity Tests; Oncorhynchus mykiss; Rhabdoviridae Infections | 2019 |
Changes in chemical components and antitumor activity during the heating process of Fructus Arctii.
Topics: Arctium; Cell Proliferation; Chlorogenic Acid; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Fruit; Furans; Glucosides; HL-60 Cells; Humans; Lignans; Medicine, Chinese Traditional; Quinic Acid | 2019 |
Arctigenin enhances the sensitivity of cisplatin resistant colorectal cancer cell by activating autophagy.
Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; Autophagy; Caspase 3; Caspase 9; Cell Line, Tumor; Cell Proliferation; Cisplatin; Colorectal Neoplasms; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Furans; Humans; Inhibitory Concentration 50; Lignans; Oxaliplatin; Paclitaxel; Up-Regulation | 2019 |
Arctigenin attenuates diabetic kidney disease through the activation of PP2A in podocytes.
Topics: Animals; Arctium; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Progression; Furans; Humans; Lignans; Male; Mice; Mice, Knockout; Microscopy, Electron, Transmission; Nitric Oxide Synthase Type III; Podocytes; Protein Phosphatase 2; Streptozocin; Treatment Outcome | 2019 |
Arctigenin alleviates TGF-β1-induced epithelial-mesenchymal transition and PAI-1 expression via AMPK/NF-κB pathway in peritoneal mesothelial cells.
Topics: AMP-Activated Protein Kinases; Cell Line; Epithelial Cells; Epithelial-Mesenchymal Transition; Furans; Humans; Lignans; NF-kappa B; Peritoneal Dialysis; Peritoneum; Plasminogen Activator Inhibitor 1; Promoter Regions, Genetic; Transforming Growth Factor beta1 | 2019 |
Activation of reactive oxygen species-mediated mitogen-activated protein kinases pathway regulates both extrinsic and intrinsic apoptosis induced by arctigenin in Hep G2.
Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Carcinoma, Hepatocellular; Enzyme Activation; Furans; Hep G2 Cells; Humans; Lignans; Liver Neoplasms; Mice, Inbred BALB C; Mice, Nude; Mitogen-Activated Protein Kinases; Reactive Oxygen Species; Signal Transduction; Tumor Burden; Xenograft Model Antitumor Assays | 2020 |
Arctigenin alleviates myocardial infarction injury through inhibition of the NFAT5-related inflammatory phenotype of cardiac macrophages/monocytes in mice.
Topics: Animals; Furans; Heart; Inflammation; Lignans; Macrophages; Male; Mice; Mice, Inbred C57BL; Monocytes; Myocardial Infarction; Myocardium; RAW 264.7 Cells; Signal Transduction; Transcription Factors | 2020 |
Arctigenin promotes bone formation involving PI3K/Akt/PPARγ signaling pathway.
Topics: Alkaline Phosphatase; Animals; Calcium; Cell Differentiation; Cell Proliferation; Furans; Gene Expression Regulation; Humans; Lignans; Mesenchymal Stem Cells; Osteoblasts; Osteogenesis; Phosphatidylinositol 3-Kinases; Phosphorus; Phosphorylation; PPAR gamma; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction | 2020 |
Pharmacological activation of ERβ by arctigenin maintains the integrity of intestinal epithelial barrier in inflammatory bowel diseases.
Topics: Animals; Caco-2 Cells; Estrogen Receptor beta; Female; Furans; HT29 Cells; Humans; Inflammatory Bowel Diseases; Interleukin-1beta; Intestinal Mucosa; Lignans; Mice; Mice, Inbred BALB C; Mutation, Missense; Myosin-Light-Chain Kinase; Signal Transduction; Tumor Necrosis Factor-alpha | 2020 |
Arctigenin inhibits prostate tumor growth in high-fat diet fed mice through dual actions on adipose tissue and tumor.
Topics: Adipocytes; Adipokines; Adipose Tissue; Administration, Oral; Animals; Cell Line, Tumor; Cell Proliferation; Cytokines; Diet, High-Fat; Disease Models, Animal; Dose-Response Relationship, Drug; Furans; Homeodomain Proteins; Humans; Lignans; Male; Mice; Obesity; Prostate; Prostatic Neoplasms; Receptors, Androgen; Transcription Factors; Tumor Burden; Xenograft Model Antitumor Assays | 2020 |
Anti‑metastatic effects of arctigenin are regulated by MAPK/AP‑1 signaling in 4T‑1 mouse breast cancer cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Arctium; Cell Line, Tumor; Cell Movement; Female; Furans; Humans; Lignans; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Neoplasm Invasiveness; Phosphorylation; Signal Transduction; Transcription Factor AP-1; Triple Negative Breast Neoplasms | 2020 |
Proteome interrogation using gold nanoprobes to identify targets of arctigenin in fish parasites.
Topics: Animals; Biological Transport; Drug Discovery; Fishes; Furans; Gene Expression Regulation; Gold; Lignans; Metal Nanoparticles; Mitochondria; Molecular Structure; Myosins; Platyhelminths; Protein Binding; Proteome; Proteomics; Reproducibility of Results; RNA, Messenger; Structure-Activity Relationship; Surface Properties | 2020 |
Arctigenin prevents the progression of osteoarthritis by targeting PI3K/Akt/NF-κB axis: In vitro and in vivo studies.
Topics: Animals; Cartilage, Articular; Chondrocytes; Dinoprostone; Disease Models, Animal; Disease Progression; Furans; Humans; Inflammation; Interleukin-1beta; Interleukin-6; Lignans; Mice; Molecular Docking Simulation; NF-kappa B; Nitric Oxide Synthase Type II; Nitrous Oxide; Osteoarthritis; Phosphatidylinositol 3-Kinases; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Signal Transduction | 2020 |
Arctigenin, a novel TMEM16A inhibitor for lung adenocarcinoma therapy.
Topics: Adenocarcinoma of Lung; Animals; Anoctamin-1; Antineoplastic Agents; Cell Line; Furans; Humans; Lignans; Lung Neoplasms; MAP Kinase Signaling System; Mice, Inbred BALB C | 2020 |
Arctigenin suppresses cell proliferation via autophagy inhibition in hepatocellular carcinoma cells.
Topics: Adenine; Apoptosis; Apoptosis Regulatory Proteins; Arctium; Autophagy; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Chloroquine; Forsythia; Furans; Hep G2 Cells; Humans; Lignans; Liver Neoplasms; Sequestosome-1 Protein | 2020 |
Arctigenin Enhances the Cytotoxic Effect of Doxorubicin in MDA-MB-231 Breast Cancer Cells.
Topics: Antibiotics, Antineoplastic; Apoptosis; Biomarkers, Tumor; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Doxorubicin; Drug Synergism; Furans; Gene Expression Regulation, Neoplastic; Humans; Lignans; MAP Kinase Signaling System; Mitochondria; Phosphorylation | 2020 |
Discovery of stereospecific cytotoxicity of (8R,8'R)-trans-arctigenin against insect cells and structure-activity relationship on aromatic ring.
Topics: Aedes; Animals; Furans; HL-60 Cells; Humans; Insecticides; Lignans; Molecular Structure; RNA, Ribosomal, 28S; Sf9 Cells; Spodoptera; Stereoisomerism; Structure-Activity Relationship | 2020 |
Arctigenin exhibits hepatoprotective activity in Toxoplasma gondii-infected host through HMGB1/TLR4/NF-κB pathway.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cell Line; Female; Furans; HMGB1 Protein; Lignans; Liver; Mice, Inbred BALB C; NF-kappa B; Protective Agents; Signal Transduction; Toll-Like Receptor 4; Toxoplasma; Toxoplasmosis | 2020 |
Evaluation on antiviral activity of a novel arctigenin derivative against multiple rhabdoviruses in aquaculture.
Topics: Animals; Antiviral Agents; Aquaculture; Cell Line; Fish Diseases; Fishes; Furans; Lignans; Rhabdoviridae; Rhabdoviridae Infections; Virus Replication | 2020 |
Arctigenin inhibits proliferation of ER-positive breast cancer cells through cell cycle arrest mediated by GSK3-dependent cyclin D1 degradation.
Topics: Breast Neoplasms; Cell Cycle Checkpoints; Cell Proliferation; Cyclin D1; Dose-Response Relationship, Drug; Female; Furans; Glycogen Synthase Kinase 3; Humans; Lignans; MCF-7 Cells; Proteolysis; Receptors, Estrogen | 2020 |
Arctigenin attenuates platelet activation and clot retraction by regulation of thromboxane A
Topics: Blood Platelets; Clot Retraction; Cyclic AMP; Fibrinolytic Agents; Furans; Glycogen Synthase Kinase 3 beta; Humans; In Vitro Techniques; Lignans; Mitogen-Activated Protein Kinases; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Platelet Activation; Platelet Aggregation Inhibitors; Signal Transduction; Thromboxane A2; TOR Serine-Threonine Kinases | 2020 |
Arctigenin disrupts NLRP3 inflammasome assembly in colonic macrophages via downregulating fatty acid oxidation to prevent colitis-associated cancer.
Topics: Animals; Carnitine O-Palmitoyltransferase; Colitis-Associated Neoplasms; Colon; Down-Regulation; Fatty Acids; Furans; Inflammasomes; Interleukin-1beta; Lignans; Macrophages; Male; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidation-Reduction | 2020 |
Arctigenin Attenuates Breast Cancer Progression through Decreasing GM-CSF/TSLP/STAT3/β-Catenin Signaling.
Topics: Animals; Apoptosis; beta Catenin; Biomarkers, Tumor; Breast Neoplasms; Cell Movement; Cell Proliferation; Cytokines; Female; Furans; Gene Expression Regulation, Neoplastic; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Lignans; Mice; Mice, Inbred BALB C; Mice, Nude; STAT3 Transcription Factor; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2020 |
Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1/TLR4/NF-κB and TNF-α/TNFR1/NF-κB pathways.
Topics: Animals; Depression; Furans; HMGB1 Protein; Lignans; Mice; Microglia; NF-kappa B; Receptors, Tumor Necrosis Factor, Type I; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2020 |
Arctigenin Inhibits Glioblastoma Proliferation through the AKT/mTOR Pathway and Induces Autophagy.
Topics: Apoptosis; Autophagy; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Furans; Glioblastoma; Glioma; Humans; Lignans; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases | 2020 |
Arctigenin suppresses fibroblast activity and extracellular matrix deposition in hypertrophic scarring by reducing inflammation and oxidative stress.
Topics: Animals; Antioxidants; Bleomycin; Cicatrix, Hypertrophic; Cytokines; Disease Models, Animal; Extracellular Matrix; Female; Fibroblasts; Fibrosis; Furans; Inflammation; Lignans; Malondialdehyde; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Oxidative Stress; Pulmonary Fibrosis; Superoxide Dismutase; Transforming Growth Factor beta1 | 2020 |
Simultaneous quantification of arctigenin and its glucuronide conjugate in mouse plasma using ultra-high performance liquid chromatography coupled to tandem mass spectrometry.
Topics: Animals; Chromatography, High Pressure Liquid; Furans; Glucuronides; Lignans; Male; Mice; Mice, Inbred BALB C; Tandem Mass Spectrometry | 2021 |
A preliminary investigation on the mechanism of action of 4-(8-(2-ethylimidazole)octyloxy)-arctigenin against IHNV.
Topics: Animals; Antiviral Agents; Cell Line; Fish Diseases; Furans; Imidazoles; Infectious hematopoietic necrosis virus; Lignans; Rhabdoviridae Infections | 2021 |
Arctigenin Triggers Apoptosis and Autophagy via PI3K/Akt/mTOR Inhibition in PC-3M Cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Arctium; Autophagy; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Furans; Humans; Lignans; Molecular Conformation; Phosphatidylinositol 3-Kinase; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; TOR Serine-Threonine Kinases; Tumor Cells, Cultured | 2021 |
Arctigenin-mediated cell death of SK-BR-3 cells is caused by HER2 inhibition and autophagy-linked apoptosis.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Female; Furans; Gene Expression Regulation, Neoplastic; Humans; Lignans; Receptor, ErbB-2; Signal Transduction | 2021 |
Arctigenin inhibits cholangiocarcinoma progression by regulating cell migration and cell viability via the N-cadherin and apoptosis pathway.
Topics: Antigens, CD; Antineoplastic Agents, Phytogenic; Apoptosis; Bile Duct Neoplasms; Biomarkers, Tumor; Cadherins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cholangiocarcinoma; Disease Progression; Female; Furans; Humans; Lignans; Male; Middle Aged; Prognosis | 2021 |
Targeting Tristetraprolin Expression or Functional Activity Regulates Inflammatory Response Induced by MSU Crystals.
Topics: Animals; Anti-Inflammatory Agents; Autophagy; Caspase 1; Cell Culture Techniques; Cytokines; Furans; Inflammation; Lignans; Lysosomes; Mice; Mice, Inbred C57BL; Mitochondria; Protein Phosphatase 2; Reactive Oxygen Species; RNA, Small Interfering; Tristetraprolin; Uric Acid | 2021 |
Arctigenin Exerts Neuroprotective Effect by Ameliorating Cortical Activities in Experimental Autoimmune Encephalomyelitis
Topics: Animals; Calcium; Encephalomyelitis, Autoimmune, Experimental; Excitatory Postsynaptic Potentials; Female; Furans; Lignans; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Somatosensory Cortex | 2021 |
Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation.
Topics: Animals; Cyclic Nucleotide Phosphodiesterases, Type 4; Furans; Humans; Inflammation; Leukocytes, Mononuclear; Lignans; Mice | 2021 |
Arctigenin alleviates cadmium-induced nephrotoxicity: Targeting endoplasmic reticulum stress, Nrf2 signaling, and the associated inflammatory response.
Topics: Animals; Cadmium; Endoplasmic Reticulum Stress; Furans; Inflammation Mediators; Kidney Diseases; Lignans; Male; NF-E2-Related Factor 2; Rats, Wistar | 2021 |
Anti-IgE effect of small-molecule-compound arctigenin on food allergy in association with a distinct transcriptome profile.
Topics: Animals; Antibodies, Anti-Idiotypic; Food Hypersensitivity; Furans; Humans; Lignans; Mice; Peanut Hypersensitivity; Plant Extracts; Transcriptome | 2022 |
Anti-inflammatory activity of arctigenin against PCV2 infection in a mouse model.
Topics: Animals; Anti-Inflammatory Agents; Circoviridae Infections; Cytokines; Drugs, Chinese Herbal; Furans; Lignans; Mice; Mice, Inbred BALB C; NF-kappa B; NF-KappaB Inhibitor alpha; Swine | 2022 |
Arctigenin inhibits abnormal germinal center reactions and attenuates murine lupus by inhibiting IFN-I pathway.
Topics: Animals; B-Lymphocytes; Disease Models, Animal; Furans; Germinal Center; Humans; Interferons; Lignans; Lupus Erythematosus, Systemic; Mice; Mice, Inbred C57BL; Signal Transduction | 2022 |
In vitro and in vivo inhibition of a novel arctigenin derivative on aquatic rhabdovirus.
Topics: Animals; Antiviral Agents; Carps; Fish Diseases; Furans; Lignans; Rhabdoviridae; Rhabdoviridae Infections; Zebrafish | 2022 |
Phytoestrogen arctigenin preserves the mucus barrier in inflammatory bowel diseases by inhibiting goblet cell apoptosis via the ERβ/TRIM21/PHB1 pathway.
Topics: Animals; Apoptosis; Colitis; Estrogen Receptor beta; Furans; Goblet Cells; Inflammatory Bowel Diseases; Lignans; Mice; Mice, Inbred C57BL; Mucus; Phytoestrogens; Prohibitins | 2022 |
Arctigenin inhibits apoptosis, extracellular matrix degradation, and inflammation in human nucleus pulposus cells by up-regulating miR-483-3p.
Topics: Apoptosis; Cells, Cultured; Extracellular Matrix; Extracellular Matrix Proteins; Furans; Humans; Inflammation; Intervertebral Disc Degeneration; Lignans; MicroRNAs; NF-kappa B; Nucleus Pulposus | 2022 |
Preventive effects of arctigenin from Arctium lappa L against LPS-induced neuroinflammation and cognitive impairments in mice.
Topics: Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Arctium; Aspartic Acid Endopeptidases; Cognitive Dysfunction; Furans; Inflammation; Lignans; Lipopolysaccharides; Memory Disorders; Mice; Microglia; Neuroinflammatory Diseases; NF-kappa B; Toll-Like Receptor 4 | 2022 |
Ameliorative Effects of Arctigenin on Pulmonary Fibrosis Induced by Bleomycin via the Antioxidant Activity.
Topics: Animals; Antioxidants; Bleomycin; Collagen; Fibrosis; Furans; Glutathione; Lignans; Lung; Mice; Pulmonary Fibrosis | 2022 |
Arctigenin: pharmacology, total synthesis, and progress in structure modification.
Topics: Anti-Inflammatory Agents; Arctium; Furans; Lignans | 2022 |
Anti-glutamatergic Effects of Three Lignan Compounds: Arctigenin, Matairesinol and Trachelogenin - An ex vivo Study on Rat Brain Slices.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Hippocampus; Lignans; Rats | 2023 |
Synthesis and Anti-Proliferative Evaluation of Arctigenin Analogues with C-9' Derivatisation.
Topics: Furans; Humans; Lactones; Lignans | 2023 |
Arctigenin Prevents Retinal Edema in a Murine Retinal Vein Occlusion Model.
Topics: Animals; Diabetic Retinopathy; Endothelial Cells; Humans; Lignans; Macular Edema; Mice; Microcirculation; Papilledema; Retinal Vein Occlusion; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2023 |
Chemoproteomics reveals arctigenin as a phagophore-closure blocker via targeting ESCRT-I subunit VPS28.
Topics: Autophagosomes; Endosomal Sorting Complexes Required for Transport; Furans; Lignans | 2023 |
Arctigenin improves neuropathy via ameliorating apoptosis and modulating autophagy in streptozotocin-induced diabetic mice.
Topics: Animals; Antioxidants; Apoptosis; Autophagy; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Lignans; Mice; Oxidative Stress; Streptozocin | 2023 |
Arctigenin derivatives improve exercise performance in mice: synthesis and biological evaluation.
Topics: Animals; Furans; Lignans; Mice; Superoxide Dismutase; Swimming | 2023 |