arcaine and biguanides

arcaine has been researched along with biguanides in 77 studies

Research

Studies (77)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (5.19)	18.7374
1990's	38 (49.35)	18.2507
2000's	21 (27.27)	29.6817
2010's	14 (18.18)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Britt, M; Paschetto, KA; Powel, RJ; Pullan, LM; Stumpo, RJ	1
Donevan, SD; Jones, SM; Rogawski, MA	1
MacDonald, RL; Rock, DM	1
Johnson, KM; Wang, J	1
Reynolds, IJ	4
Canton, H; Colpaert, F; Lehmann, J	1
Blair, R; Woodward, JJ	1
Bednar, DL; Karbon, EW; Maciver, CR	1
Johnson, KM; Sacaan, AI	2
Hiramatsu, M; Mori, A; Numoto, A; Robin, Y	1
Bagga, L; Derks, M; Doyle, KM; Purcell, WM	1
Asahara, H; Habu, H; Kabuto, H; Mori, A; Yokoi, I	1
Calligaro, DO; Monn, JA; O'Malley, PJ	1
Oblin, A; Schoemaker, H	1
Berrino, L; Leyva, J; Maione, S; Pizzirusso, A; Rossi, F; Stella, L	1
Baudry, M; Marvizón, JC	1
Hoss, W; Kothapalli, MR; Periyasamy, S	1
Berrino, L; Filippelli, A; Leyva, J; Maione, S; Pizzirusso, A; Rossi, F; Vitagliano, S	1
Foster, AC; Grimwood, S; Struthers, L	1
Burns, MA; Palmer, AM	1
Chandler, P; Maccecchini, ML; Nashed, NT; Pennington, M; Skolnick, P	1
de Costa, BR; He, XS; Li, G; Skolnick, P; Zhou, LM	1
Reynolds, IJ; Rothermund, KD	1
Artemowicz, B; Lutostanska, A; Wiśniewski, K	2
Wiley, JL	1
Doyle, KM; Shaw, GG	1
Brierley, MJ; Harris, J; Mellor, IR; Shao, Z; Usherwood, PN	1
Balster, RL; Nicholson, KL	1
Carr, AJ; Davis, RS; Hamilton, AD; Reynolds, IJ; Sharma, TA	1
Araneda, RC; Bennett, MV; Lan, JY; Zheng, X; Zukin, RS	1
Meyerhoff, JL; Repasi, RT; Rittase, WB; Staten, LD; Yourick, DL	1
Sharif, NA; Xu, SX	1
Daeffler, L; Eichwald, V; Landry, Y; Nadra, K; Ohresser, S	1
Bertrand, S; Cazalets, JR	1
Boemo, RL; Jurach, A; Mello, CF; Obregon, AD; Rojas, DB; Rubin, MA; Souza, DO; Zanolla, GR	1
Agrò, AF; Floris, G; Lorrai, A; Medda, R; Murgia, B; Padiglia, A; Pedersen, JZ	1
Boemo, RL; Fenili, AC; Jurach, A; Mello, CF; Oliveira, DM; Rubin, MA; Stiegemeier, JA; Volkweis, MA	1
Mo, LL; Sundström, E	1
Gebka, J; Kaminska, E; Mikolajczak, P; Niedopad, L; Okulicz-Kozaryn, I; Polanska, A	1
Gibson, DA; Harris, BR; Littleton, JM; Rogers, DT	1
Littleton, JM; Mulholland, PJ; Nath, A; Prendergast, MA; Rogers, DT; Self, RL; Wilkins, LH	1
Goncharenko, NV; Pankrat'ev, DV; Talalaenko, AN	1
Sakakibara, Y; Yanagisawa, H	1
ROBIN, Y; ROCHE, J	1
PRADEL, LA; ROBIN, Y; ROCHE, J	1
AUDIT, C; ROBIN, Y	1
Harris, BR; Mulholland, PJ; Nath, A; Prendergast, MA; Self, RL	1
Awe, SO; Harris, LC; Kulkarni, K; LeDay, AM; Ohia, SE; Opere, CA; Sharif, NA	1
Berlese, DB; dos Santos, TL; Fenili, AC; Mello, CF; Oliveira, DM; Rubin, MA; Stiegemeier, JA; Volkweis, MA	1
Balster, RL; Wiley, JL	1
Bellé, NA; Dalmolin, GD; Fonini, G; Rocha, JB; Rubin, MA	1
Bakalkin, G; Marinova, Z; Nakagawasai, O; Niijima, F; Sakurada, S; Sato, T; Satoh, S; Tadano, T; Takahashi, H; Tan-No, K; Terenius, L; Yakovleva, T	1
Camera, K; Ceretta, AP; Mello, CF; Rubin, MA	2
Ferreira, J; Fighera, MR; Fiorenza, NG; Furian, AF; Mello, CF; Oliveira, MS; Royes, LF; Rubin, MA	1
Dalmolin, GD; Ferreira da Silveira, A; Fonini, G; Gindri Sinhorin, VD; Mello, CF; Rubin, MA; Velloso, NA	1
Gmiro, VE; Serdyuk, SE	1
Efremov, OM; Gmiro, VE; Serdyuk, SE	1
Barron, S; Bochi, GV; da Rosa, MM; Ferreira, J; Gomes, GM; Mello, CF; Rubin, MA	1
Chopde, CT; Kotagale, NR; Patel, MR; Shelkar, GP; Taksande, BG; Ugale, RR	1
Chopde, CT; Gahane, AY; Kotagale, NR; Taksande, BG; Ugale, RR	1
Camera, K; Ceretta, AP; Mariani, RK; Mello, CF; Rosa, MM; Rubin, MA	1
Bochi, GV; Calixto, JB; Dutra, RC; Fachinetto, R; Ferreira, J; Guerra, GP; Mello, CF; Pazini, AM; Rubin, MA	1
Camera, K; Ceretta, AP; da Rosa, MM; Mello, CF; Ribeiro, DA; Rubin, MA; Signor, C	1
Carvalho, FB; Ferreira, J; Girardi, BA; Marisco, PC; Mello, CF; Oliveira, MS; Rubin, MA; Tonello, R	1
Aglawe, MM; Chopde, CT; Kotagale, NR; Taksande, BG; Tripathi, SJ; Umekar, MJ	1
Mello, CF; Ribeiro, DA; Rubin, MA; Signor, C	1
Mello, CF; Porto, GP; Ribeiro, DA; Rubin, MA; Signor, C	1
Bär, J; Dalmolin, GD; Gomes, GM; Karpova, A; Kreutz, MR; Mello, CF; Rubin, MA	1
Gais, MA; Girardi, BA; Mello, CF; Muller, M; Ribeiro, DA; Rubin, MA; Signor, C	1
Funck, VR; Gais, MA; Girardi, BA; Mello, CF; Oliveira, MS; Rubin, MA; Signor, C; Temp, FR	1
Aglawe, MM; Chopde, CT; Gujar, S; Khade, SD; Kotagale, NR; Taksande, BG	1

Other Studies

77 other study(ies) available for arcaine and biguanides

Article	Year
Neomycin is an agonist at a polyamine site on the N-methyl-D-aspartate receptor. Journal of neurochemistry, 1992, Volume: 59, Issue:6 Topics: Adrenergic alpha-Antagonists; Animals; Biguanides; Magnesium; Male; Neomycin; Phencyclidine; Piperazines; Piperidines; Polyamines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Synaptic Membranes; Tritium	1992
Arcaine blocks N-methyl-D-aspartate receptor responses by an open channel mechanism: whole-cell and single-channel recording studies in cultured hippocampal neurons. Molecular pharmacology, 1992, Volume: 41, Issue:4 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biguanides; Cations, Divalent; Cells, Cultured; Dizocilpine Maleate; gamma-Aminobutyric Acid; Glycine; Hippocampus; Ibotenic Acid; Ion Channels; Kainic Acid; Magnesium; Membrane Potentials; N-Methylaspartate; Neurons; Polyamines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate	1992
Spermine and related polyamines produce a voltage-dependent reduction of N-methyl-D-aspartate receptor single-channel conductance. Molecular pharmacology, 1992, Volume: 42, Issue:1 Topics: Animals; Biguanides; Cells, Cultured; Cerebral Cortex; Hydrogen-Ion Concentration; Ion Channel Gating; Ion Channels; Membrane Potentials; N-Methylaspartate; Neurons; Polyamines; Putrescine; Rats; Receptors, N-Methyl-D-Aspartate; Spermine	1992
Arcaine and magnesium inhibition of the NMDA receptor ionophore complex: evidence for distinct voltage-dependent sites. Canadian journal of physiology and pharmacology, 1992, Volume: 70, Issue:2 Topics: Animals; Biguanides; In Vitro Techniques; Magnesium; Male; Norepinephrine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate	1992
Interactions between zinc and spermidine on the N-methyl-D-aspartate receptor complex: clues to the mechanism of action of 1,10-bis(guanidino)decane and pentamidine. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 263, Issue:2 Topics: Animals; Biguanides; Binding Sites; Brain Chemistry; Diethyl Pyrocarbonate; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Guanidines; Pentamidine; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Zinc	1992
Glutamate and glycine co-activate while polyamines merely modulate the NMDA receptor complex. Progress in neuro-psychopharmacology & biological psychiatry, 1991, Volume: 15, Issue:2 Topics: 2-Amino-5-phosphonovalerate; Adrenergic alpha-Antagonists; Animals; Biguanides; Binding, Competitive; Biogenic Polyamines; Biotransformation; Brain; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Kynurenic Acid; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine	1991
Redox modulation of N-methyl-D-aspartate-stimulated neurotransmitter release from rat brain slices. Journal of neurochemistry, 1991, Volume: 57, Issue:6 Topics: Animals; Biguanides; Brain; Disulfides; Dithionitrobenzoic Acid; Dithiothreitol; Dose-Response Relationship, Drug; In Vitro Techniques; Kynurenic Acid; Male; N-Methylaspartate; Neurotransmitter Agents; Osmolar Concentration; Oxidation-Reduction; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate	1991
Opposite effects of spermine and arcaine on responses of N-methyl-D-aspartate receptors expressed in Xenopus oocytes. Neuroscience letters, 1991, Nov-11, Volume: 132, Issue:2 Topics: Animals; Biguanides; Glycine; N-Methylaspartate; Oocytes; Polyamines; Receptors, N-Methyl-D-Aspartate; Spermine; Xenopus	1991
Competitive inhibition of magnesium-induced [3H]N-(1-[thienyl] cyclohexyl)piperidine binding by arcaine: evidence for a shared spermidine-magnesium binding site. Molecular pharmacology, 1990, Volume: 38, Issue:5 Topics: Animals; Biguanides; Binding Sites; Binding, Competitive; Dose-Response Relationship, Drug; Drug Interactions; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Magnesium; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Strychnine	1990
Arcaine uncovers dual interactions of polyamines with the N-methyl-D-aspartate receptor. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 255, Issue:3 Topics: Animals; Biguanides; Binding, Competitive; Cations, Divalent; Dizocilpine Maleate; Drug Interactions; Kinetics; Polyamines; Rats; Receptors, N-Methyl-D-Aspartate; Tritium	1990
Spermidine reverses arcaine's inhibition of N-methyl-D-aspartate-induced hippocampal [3H]norepinephrine release. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 255, Issue:3 Topics: Animals; Biguanides; Binding Sites; Dimethyl Sulfoxide; Hippocampus; Hydrogen-Ion Concentration; Intracellular Fluid; Male; N-Methylaspartate; Norepinephrine; Polyamines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spermidine; Tritium	1990
Arcaine is a competitive antagonist of the polyamine site on the NMDA receptor. European journal of pharmacology, 1990, Feb-27, Volume: 177, Issue:3 Topics: Biguanides; Binding, Competitive; Biogenic Polyamines; Dibenzocycloheptenes; Dizocilpine Maleate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spermidine	1990
[Convulsant action of the diguanide derivatives hirudonine, arcaine and audouine]. Comptes rendus des seances de la Societe de biologie et de ses filiales, 1981, Volume: 175, Issue:6 Topics: Administration, Topical; Amidines; Animals; Biguanides; Convulsants; Electroencephalography; Motor Cortex; Rabbits; Somatosensory Cortex; Spermidine; Time Factors	1981
Histamine release from mast cells by polyamines: an NMDA receptor-mediated event? Biochemical Society transactions, 1994, Volume: 22, Issue:4 Topics: Animals; Biguanides; Dizocilpine Maleate; Histamine Release; In Vitro Techniques; Kinetics; Mast Cells; p-Methoxy-N-methylphenethylamine; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Spermine	1994
Inhibitory effect of arcaine on nitric oxide synthase in the rat brain. Neuroreport, 1995, Feb-15, Volume: 6, Issue:3 Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biguanides; Brain; Dose-Response Relationship, Drug; Male; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley	1995
beta-Amyloid (25-35) or substance P stimulates [3H]MK-801 binding to rat cortical membranes in the presence of glutamate and glycine. Journal of neurochemistry, 1993, Volume: 60, Issue:6 Topics: Amino Acid Sequence; Amyloid beta-Peptides; Animals; Biguanides; Cell Membrane; Cerebral Cortex; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Kinetics; Molecular Sequence Data; N-Methylaspartate; Peptide Fragments; Pipecolic Acids; Rats; Receptors, N-Methyl-D-Aspartate; Sequence Homology, Amino Acid; Substance P	1993
[3H]CGP 39653 binding to the agonist site of the N-methyl-D-aspartate receptor is modulated by Mg2+ and polyamines independently of the arcaine-sensitive polyamine site. Journal of neurochemistry, 1994, Volume: 62, Issue:1 Topics: 2-Amino-5-phosphonovalerate; Animals; Biguanides; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Glycine; Kinetics; Magnesium; Polyamines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine; Tritium	1994
Complex allosteric modulation of the binding of the NMDA receptor antagonist [3H]CGP39653. European journal of pharmacology, 1994, Jan-01, Volume: 266, Issue:1 Topics: 2-Amino-5-phosphonovalerate; Allosteric Regulation; Animals; Biguanides; Binding Sites; Glycine; In Vitro Techniques; Kynurenic Acid; Male; Piperidines; Prosencephalon; Putrescine; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine	1994
Evidence that arcaine increases the N-methyl-D-aspartate-induced cardiovascular effects into the periaqueductal gray area of anesthetized rats. Neuroscience letters, 1994, Jan-03, Volume: 165, Issue:1-2 Topics: 2-Amino-5-phosphonovalerate; Anesthesia; Animals; Biguanides; Blood Pressure; Dizocilpine Maleate; Dose-Response Relationship, Drug; Heart Rate; Hemodynamics; Male; N-Methylaspartate; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate	1994
[3H]dizocilpine association kinetics distinguish stimulatory and inhibitory polyamine sites of N-methyl-D-aspartate receptors. Journal of neurochemistry, 1994, Volume: 63, Issue:3 Topics: Animals; Biguanides; Binding Sites; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Kinetics; Male; Piperidines; Polyamines; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine; Tritium	1994
Regulation of the phosphoinositide cascade by polyamines in brain. Journal of neurochemistry, 1994, Volume: 63, Issue:4 Topics: Agmatine; Animals; Biguanides; Calcium; Cell Membrane; Cerebral Cortex; Deoxycholic Acid; Guanosine 5'-O-(3-Thiotriphosphate); Homeostasis; Kinetics; Male; Phosphatidylinositols; Polyamines; Rats; Spermidine; Spermine	1994
Effects of the polyamine spermidine on NMDA-induced arterial hypertension in freely moving rats. Neuropharmacology, 1994, Volume: 33, Issue:6 Topics: Animals; Biguanides; Blood Pressure; Drug Synergism; Hypertension; Male; Microinjections; N-Methylaspartate; Periaqueductal Gray; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine	1994
Polyamines modulate [3H]L-689,560 binding to the glycine site of the NMDA receptor from rat brain. European journal of pharmacology, 1994, Jan-01, Volume: 266, Issue:1 Topics: Aminoquinolines; Animals; Biguanides; Binding, Competitive; Cerebral Cortex; Diamines; Dose-Response Relationship, Drug; Glycine; Hippocampus; Polyamines; Putrescine; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine	1994
Preservation of redox, polyamine, and glycine modulatory domains of the N-methyl-D-aspartate receptor in Alzheimer's disease. Journal of neurochemistry, 1994, Volume: 62, Issue:1 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Biguanides; Binding Sites; Brain; Cell Membrane; Cerebral Cortex; Dithionitrobenzoic Acid; Dizocilpine Maleate; Female; Frontal Lobe; Glycine; Humans; Male; Middle Aged; Organ Specificity; Oxidation-Reduction; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Spermidine; Temporal Lobe	1994
Polyamine-like actions of peptides derived from conantokin-G, an N-methyl-D-aspartate (NMDA) antagonist. The Journal of biological chemistry, 1993, Aug-15, Volume: 268, Issue:23 Topics: Amino Acid Sequence; Animals; Biguanides; Circular Dichroism; Conotoxins; Magnesium; Male; Molecular Sequence Data; N-Methylaspartate; Peptides, Cyclic; Polyamines; Rats; Rats, Sprague-Dawley; Spermine	1993
Synthesis of N,N'-substituted piperazine and homopiperazine derivatives with polyamine-like actions at N-methyl-D-aspartate receptors. Journal of medicinal chemistry, 1995, Dec-08, Volume: 38, Issue:25 Topics: Animals; Biguanides; Brain; In Vitro Techniques; Male; Piperazines; Polyamines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine; Structure-Activity Relationship	1995
Characterization of the effects of polyamines on the modulation of the N-methyl-D-aspartate receptor by glycine. Neuropharmacology, 1995, Volume: 34, Issue:9 Topics: Animals; Biguanides; Binding, Competitive; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glycine; Polyamines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate	1995
The role of NMDA receptors in central action of angiotensin II. Acta physiologica Hungarica, 1996, Volume: 84, Issue:3 Topics: Angiotensin II; Animals; Avoidance Learning; Biguanides; Brain; Conditioning, Psychological; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Male; Memory; Motor Activity; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate	1996
The estimation of interactions between arginine-vasopressin (AVP) and NMDA receptors in memory and learning processes. Acta physiologica Hungarica, 1996, Volume: 84, Issue:4 Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine Vasopressin; Biguanides; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Learning; Male; Memory; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate	1996
Nitric oxide synthase inhibitors attenuate phencyclidine-induced disruption of prepulse inhibition. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1998, Volume: 19, Issue:1 Topics: Acoustic Stimulation; Animals; Biguanides; Biogenic Polyamines; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Indazoles; Inhibition, Psychological; Male; Nitric Oxide Synthase; Nitroarginine; Phencyclidine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex, Startle	1998
Investigation of the actions and antagonist activity of some polyamine analogues in vivo. British journal of pharmacology, 1998, Volume: 124, Issue:2 Topics: Animals; Behavior, Animal; Biguanides; Central Nervous System; Diamines; Dose-Response Relationship, Drug; Drug Antagonism; Drug Synergism; Female; Injections, Intraventricular; Mice; Polyamines; Seizures; Spermine; Tremor	1998
Potentiation and inhibition of nicotinic acetylcholine receptors by spermine in the TE671 human muscle cell line. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 286, Issue:3 Topics: Acetylcholine; Biguanides; Cell Line; Drug Synergism; Humans; Muscles; Receptors, Nicotinic; Spermine	1998
Phencyclidine-like discriminative stimulus effects of polyamine modulators of N-methyl-D-aspartate receptor activity in rats. Neuroscience letters, 1998, Aug-28, Volume: 253, Issue:1 Topics: Animals; Biguanides; Discrimination Learning; Male; Motivation; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reinforcement, Psychology; Spermidine; Spermine	1998
Aromatic analogs of arcaine inhibit MK-801 binding to the NMDA receptor. Bioorganic & medicinal chemistry letters, 1998, Dec-15, Volume: 8, Issue:24 Topics: Biguanides; Dizocilpine Maleate; Protein Binding; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship	1998
Spermine and arcaine block and permeate N-methyl-D-aspartate receptor channels. Biophysical journal, 1999, Volume: 76, Issue:6 Topics: Animals; Biguanides; Biophysical Phenomena; Biophysics; Cells, Cultured; Electrochemistry; Female; Hippocampus; In Vitro Techniques; Kinetics; Membrane Potentials; Models, Biological; Models, Molecular; Molecular Conformation; Oocytes; Patch-Clamp Techniques; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Spermine; Xenopus laevis	1999
Ifenprodil and arcaine alter amygdala-kindling development. European journal of pharmacology, 1999, Apr-29, Volume: 371, Issue:2-3 Topics: Amygdala; Animals; Anticonvulsants; Biguanides; Brain; Dose-Response Relationship, Drug; Electric Stimulation; Injections, Intraventricular; Kindling, Neurologic; Male; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures	1999
Human retina contains polyamine sensitive [3H]-ifenprodil binding sites: implications for neuroprotection? The British journal of ophthalmology, 1999, Volume: 83, Issue:2 Topics: Aged; Aged, 80 and over; Biguanides; Binding Sites; Excitatory Amino Acid Antagonists; Humans; N-Methylaspartate; Neuroprotective Agents; Piperidines; Polyamines; Receptors, N-Methyl-D-Aspartate; Retina	1999
Effect of NMDA receptor ligands on mast cell histamine release, a reappraisal. Naunyn-Schmiedeberg's archives of pharmacology, 1999, Volume: 359, Issue:6 Topics: Animals; Biguanides; Biogenic Polyamines; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Histamine Release; In Vitro Techniques; Ligands; Male; Mast Cells; N-Acetylneuraminic Acid; Neuraminidase; Peritoneal Cavity; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Spermine	1999
Regulation by glycine, Mg2+ and polyamines of the N-methyl-D-aspartate-induced locomotion in the neonatal rat spinal cord in vitro. Neuroscience, 1999, Volume: 94, Issue:4 Topics: Animals; Biguanides; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Kynurenic Acid; Magnesium; Motor Activity; Motor Neurons; N-Methylaspartate; Polyamines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermine; Spinal Cord; Synapses	1999
Intrahippocampal spermidine administration improves inhibitory avoidance performance in rats. Behavioural pharmacology, 2000, Volume: 11, Issue:1 Topics: Animals; Avoidance Learning; Biguanides; Hippocampus; Injections; Male; Motor Activity; Rats; Rats, Wistar; Spermidine	2000
Interaction of pig kidney and lentil seedling copper-containing amine oxidases with guanidinium compounds. Journal of enzyme inhibition, 2000, Volume: 15, Issue:1 Topics: Amiloride; Amine Oxidase (Copper-Containing); Animals; Biguanides; Binding, Competitive; Catalysis; Enzyme Inhibitors; Fabaceae; Guanidines; Kidney; Kinetics; Plants, Medicinal; Spectrophotometry; Structure-Activity Relationship; Swine	2000
Intra-amygdala spermidine administration improves inhibitory avoidance performance in rats. European journal of pharmacology, 2001, Jun-29, Volume: 423, Issue:1 Topics: Amygdala; Animals; Avoidance Learning; Behavior, Animal; Biguanides; Dose-Response Relationship, Drug; Male; Motor Activity; Rats; Rats, Wistar; Spermidine	2001
Polyamine and redox modulation of [3H]MK-801 binding to N-methyl-D-aspartate receptors in the spinal cord and cerebral cortex. Pharmacology & toxicology, 2001, Volume: 88, Issue:6 Topics: Animals; Biguanides; Cerebral Cortex; Dizocilpine Maleate; Hydrogen-Ion Concentration; Male; Neuroprotective Agents; Oxidation-Reduction; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine; Spinal Cord; Tritium	2001
Effects of acamprosate and some polyamine site ligands of NMDA receptor on short-term memory in rats. European journal of pharmacology, 2002, May-24, Volume: 444, Issue:1-2 Topics: Acamprosate; Administration, Oral; Animals; Biguanides; Dose-Response Relationship, Drug; Drug Interactions; Male; Memory, Short-Term; Motor Activity; Piperidines; Polyamines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Sleep; Spermidine; Taurine	2002
Radioligand binding studies reveal agmatine is a more selective antagonist for a polyamine-site on the NMDA receptor than arcaine or ifenprodil. Brain research, 2002, Oct-11, Volume: 952, Issue:1 Topics: Agmatine; Animals; Biguanides; Binding Sites; Binding, Competitive; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Male; Piperidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Tritium	2002
Neurotoxic effects of the human immunodeficiency virus type-1 transcription factor Tat require function of a polyamine sensitive-site on the N-methyl-D-aspartate receptor. Brain research, 2002, Nov-08, Volume: 954, Issue:2 Topics: Animals; ATPases Associated with Diverse Cellular Activities; Biguanides; Brain; Cerebellum; Cerebral Cortex; Culture Techniques; Dizocilpine Maleate; DNA-Binding Proteins; Excitatory Amino Acid Antagonists; Female; Hippocampus; HIV-1; Male; Neurons; Neurotoxins; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine	2002
Neurochemical characteristics of the ventromedial hypothalamus in mediating the antiaversive effects of anxiolytics in different models of anxiety. Neuroscience and behavioral physiology, 2003, Volume: 33, Issue:3 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Apomorphine; Avoidance Learning; Biguanides; Brain Chemistry; Chlordiazepoxide; Clonidine; Disease Models, Animal; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Droperidol; Drug Interactions; GABA Agents; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Glutamic Acid; Male; Memantine; Mephenytoin; Microinjections; Pentylenetetrazole; Phentolamine; Picrotoxin; Piperazines; Propranolol; Pyrimidines; Rats; Serotonin; Sulpiride; Ventromedial Hypothalamic Nucleus; Yohimbine	2003
Agmatine deiminase from cucumber seedlings is a mono-specific enzyme: purification and characteristics. Protein expression and purification, 2003, Volume: 30, Issue:1 Topics: Biguanides; Chromatography, Gel; Cucumis sativus; Electrophoresis, Polyacrylamide Gel; Hydrolases; Kinetics; Molecular Weight; Multienzyme Complexes; Ornithine Carbamoyltransferase; Phosphotransferases (Carboxyl Group Acceptor); Plant Shoots; Seedlings; Substrate Specificity; Transferases	2003
[Presence of arcaine in the leech, Hirudo medicinalis L]. Comptes rendus des seances de la Societe de biologie et de ses filiales, 1957, Volume: 151, Issue:12 Topics: Amidines; Animals; Biguanides; Hirudo medicinalis; Humans; Leeches; Leeching	1957
[Phosphagen in the mollusk Arca noae & the physiological significance of arcaine in various invertebrates]. Comptes rendus des seances de la Societe de biologie et de ses filiales, 1959, Volume: 153, Issue:1 Topics: Amidines; Animals; Arcidae; Biguanides; Invertebrates; Mollusca	1959
[Biogenesis of arcaine in the leech, Hirudo medicinalis L]. Comptes rendus des seances de la Societe de biologie et de ses filiales, 1962, Volume: 156 Topics: Animals; Arginine; Biguanides; Guanidine; Guanidines; Hirudo medicinalis; Humans; Leeches; Leeching	1962
The human immunodeficiency virus type-1 transcription factor Tat produces elevations in intracellular Ca2+ that require function of an N-methyl-D-aspartate receptor polyamine-sensitive site. Brain research, 2004, Jan-02, Volume: 995, Issue:1 Topics: AIDS Dementia Complex; Animals; Biguanides; Brain; Calcium; Excitatory Amino Acid Antagonists; Female; Gene Products, tat; Hippocampus; HIV-1; In Vitro Techniques; Male; Mutation; Nerve Degeneration; Neurons; Peptide Fragments; Polyamines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; tat Gene Products, Human Immunodeficiency Virus; Up-Regulation	2004
Glucose-deprivation-induced [3H]D-aspartate release from isolated bovine and human retinae. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2003, Volume: 19, Issue:6 Topics: Alanine; Animals; Biguanides; Calcium Channel Blockers; Cattle; D-Aspartic Acid; Diltiazem; Dizocilpine Maleate; Drug Synergism; Glucose; Glutamic Acid; Glycine; Humans; Kainic Acid; N-Methylaspartate; Nitrendipine; omega-Conotoxins; Perfusion; Piperidines; Polyamines; Receptors, Glutamate; Retina; Tritium; Verapamil	2003
Intra-amygdala administration of polyamines modulates fear conditioning in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Mar-03, Volume: 24, Issue:9 Topics: Amygdala; Animals; Behavior, Animal; Biguanides; Biogenic Polyamines; Catheterization; Conditioning, Classical; Drug Administration Routes; Fear; Male; Maze Learning; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spatial Behavior; Spermidine	2004
Effects of modulators of N-methyl-D-aspartate receptor-mediated neurotransmission on diazepam discrimination in rats. Life sciences, 2004, May-28, Volume: 75, Issue:2 Topics: Amino Acids; Animals; Biguanides; Binding Sites; Conditioning, Operant; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA Agonists; Male; N-Methylaspartate; Pentobarbital; Phencyclidine; Piperazines; Quinolones; Quinoxalines; Rats; Rats, Sprague-Dawley; Riluzole	2004
Polyamines reduces lipid peroxidation induced by different pro-oxidant agents. Brain research, 2004, May-22, Volume: 1008, Issue:2 Topics: Animals; Antioxidants; Biguanides; Biogenic Polyamines; Dizocilpine Maleate; Edetic Acid; Iron; Lipid Peroxidation; Nitroprusside; Oxidants; Quinolinic Acid; Rats; Rats, Wistar; Spermidine; Spermine; Thiobarbituric Acid Reactive Substances	2004
Pronociceptive role of dynorphins in uninjured animals: N-ethylmaleimide-induced nociceptive behavior mediated through inhibition of dynorphin degradation. Pain, 2005, Volume: 113, Issue:3 Topics: Agmatine; Analysis of Variance; Animals; Behavior, Animal; Biguanides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Enkephalins; Enzyme Inhibitors; Ethylmaleimide; Excitatory Amino Acid Antagonists; Immune Sera; Injections, Spinal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Narcotics; Nociceptin Receptor; Piperidines; Protein Precursors; Receptors, Opioid; Spinal Cord; Time Factors	2005
Systemic administration of polyaminergic agents modulate fear conditioning in rats. Psychopharmacology, 2007, Volume: 192, Issue:4 Topics: Animals; Behavior, Animal; Biguanides; Conditioning, Classical; Dizocilpine Maleate; Fear; Injections, Intraperitoneal; Male; Memory; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermidine; Time Factors	2007
The involvement of the polyamines binding sites at the NMDA receptor in creatine-induced spatial learning enhancement. Behavioural brain research, 2008, Feb-11, Volume: 187, Issue:1 Topics: Animals; Biguanides; Binding Sites; Creatine; Hippocampus; Male; Maze Learning; Microinjections; Polyamines; Rats; Receptors, N-Methyl-D-Aspartate; Space Perception; Spermidine; Stimulation, Chemical	2008
Spermine attenuates behavioral and biochemical alterations induced by quinolinic acid in the striatum of rats. Brain research, 2008, Mar-10, Volume: 1198 Topics: Animals; Antioxidants; Behavior, Animal; Biguanides; Binding Sites; Binding, Competitive; Brain Chemistry; Corpus Striatum; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; Motor Activity; Oxidative Stress; Quinolinic Acids; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermine	2008
Arcaine and MK-801 make recall state-dependent in rats. Psychopharmacology, 2008, Volume: 201, Issue:3 Topics: Animals; Avoidance Learning; Behavior, Animal; Biguanides; Buffers; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Administration Schedule; Excitatory Amino Acid Antagonists; Exploratory Behavior; Injections, Intraperitoneal; Male; Mental Recall; Neuroprotective Agents; Phosphates; Polyamines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Time Factors; Transfer, Psychology	2008
Combined blockade of AMPA and NMDA receptors in the brain of rats prevents pentylenetetrazole-induced clonic and tonic-clonic seizures without ataxia. Bulletin of experimental biology and medicine, 2008, Volume: 145, Issue:6 Topics: Animals; Ataxia; Biguanides; Drug Synergism; Drug Therapy, Combination; Epilepsy, Tonic-Clonic; Male; Memantine; Pentylenetetrazole; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures	2008
Peripheral and central routes of administration of quaternary ammonium compound IEM-1460 are equally potent in reducing the severity of nicotine-induced seizures in mice. Bulletin of experimental biology and medicine, 2008, Volume: 146, Issue:1 Topics: Adamantane; Animals; Biguanides; Male; Mice; Nicotine; Receptors, AMPA; Receptors, Nicotinic; Seizures	2008
Polyaminergic agents modulate contextual fear extinction in rats. Neurobiology of learning and memory, 2010, Volume: 93, Issue:4 Topics: Animals; Biguanides; Conditioning, Classical; Excitatory Amino Acid Antagonists; Extinction, Psychological; Fear; Freezing Reaction, Cataleptic; Male; Neuropsychological Tests; Nootropic Agents; Piperidines; Polyamines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermidine	2010
Agmatine, an endogenous imidazoline receptor ligand modulates ethanol anxiolysis and withdrawal anxiety in rats. European journal of pharmacology, 2010, Jul-10, Volume: 637, Issue:1-3 Topics: Agmatine; Animals; Anti-Anxiety Agents; Anxiety; Arginine; Biguanides; Brain; Clonidine; Dose-Response Relationship, Drug; Eflornithine; Ethanol; Guanidines; Imidazoles; Imidazoline Receptors; Ligands; Maze Learning; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome	2010
Repeated agmatine treatment attenuates nicotine sensitization in mice: modulation by alpha2-adrenoceptors. Behavioural brain research, 2010, Dec-01, Volume: 213, Issue:2 Topics: Agmatine; Animals; Arginine; Biguanides; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Eflornithine; Enzyme Inhibitors; Guanidines; Idazoxan; Male; Mice; Motor Activity; Nicotine; Receptors, Adrenergic, alpha-2; Yohimbine	2010
Effect of naloxone and morphine on arcaine-induced state-dependent memory in rats. Psychopharmacology, 2011, Volume: 215, Issue:3 Topics: Analgesics, Opioid; Animals; Avoidance Learning; Biguanides; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Memory; Morphine; Naloxone; Narcotic Antagonists; Rats; Rats, Wistar	2011
Hippocampal PKA/CREB pathway is involved in the improvement of memory induced by spermidine in rats. Neurobiology of learning and memory, 2011, Volume: 96, Issue:2 Topics: Animals; Avoidance Learning; Biguanides; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Hippocampus; Memory; Phosphorylation; Rats; Signal Transduction; Spermidine	2011
Opioid mechanisms are involved in the disruption of arcaine-induced amnesia by context pre-exposure. Neurobiology of learning and memory, 2012, Volume: 97, Issue:3 Topics: Amnesia; Animals; Association Learning; Biguanides; Conditioning, Psychological; Fear; Freezing Reaction, Cataleptic; Male; Naloxone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, mu	2012
Spermidine decreases Na⁺,K⁺-ATPase activity through NMDA receptor and protein kinase G activation in the hippocampus of rats. European journal of pharmacology, 2012, Jun-05, Volume: 684, Issue:1-3 Topics: Animals; Biguanides; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dizocilpine Maleate; Enzyme Activation; Hippocampus; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Sodium-Potassium-Exchanging ATPase; Spermidine	2012
Evidences for the agmatine involvement in antidepressant like effect of bupropion in mouse forced swim test. Pharmacology, biochemistry, and behavior, 2013, Volume: 107 Topics: Agmatine; Animals; Antidepressive Agents; Arginine; Benzofurans; Biguanides; Bupropion; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Eflornithine; Guanidines; Idazoxan; Imidazoles; Immobility Response, Tonic; Injections, Intraventricular; Male; Mice; Motor Activity	2013
Polyaminergic agents modulate the reconsolidation of conditioned fear. Neurobiology of learning and memory, 2013, Volume: 104 Topics: Animals; Biguanides; Conditioning, Psychological; Fear; Male; Memory; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermidine	2013
Spermidine improves fear memory persistence. European journal of pharmacology, 2014, May-05, Volume: 730 Topics: Animals; Biguanides; Dose-Response Relationship, Drug; Fear; Male; Memory; Rats; Rats, Wistar; Spermidine; Time Factors	2014
Inhibition of the polyamine system counteracts β-amyloid peptide-induced memory impairment in mice: involvement of extrasynaptic NMDA receptors. PloS one, 2014, Volume: 9, Issue:6 Topics: Amyloid beta-Peptides; Animals; Biguanides; Binding Sites; Cell Nucleus; Dendritic Spines; Exploratory Behavior; Hippocampus; Male; Memory Disorders; Mice; Nerve Tissue Proteins; Peptide Fragments; Piperidines; Polyamines; Receptors, N-Methyl-D-Aspartate; Spermidine; Synapses	2014
Spermidine-induced improvement of reconsolidation of memory involves calcium-dependent protein kinase in rats. Learning & memory (Cold Spring Harbor, N.Y.), 2016, Volume: 23, Issue:1 Topics: Analysis of Variance; Animals; Anisomycin; Biguanides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fear; Hippocampus; Indoles; Male; Maleimides; Memory; Protein Kinases; Protein Synthesis Inhibitors; Rats; Rats, Wistar; Spermidine	2016
Intrahippocampal infusion of spermidine improves memory persistence: Involvement of protein kinase A. Neurobiology of learning and memory, 2016, Volume: 131 Topics: Animals; Anisomycin; Behavior, Animal; Biguanides; Cyclic AMP-Dependent Protein Kinases; Fear; Hippocampus; Isoquinolines; Male; Memory, Long-Term; Nootropic Agents; Polyamines; Protein Kinase Inhibitors; Protein Synthesis Inhibitors; Rats; Rats, Wistar; Spermidine; Sulfonamides	2016
Agmatine Inhibits Behavioral Sensitization to Ethanol Through Imidazoline Receptors. Alcoholism, clinical and experimental research, 2019, Volume: 43, Issue:4 Topics: Agmatine; Animals; Arginine; Benzofurans; Biguanides; Central Nervous System Sensitization; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Guanidines; Idazoxan; Imidazoles; Imidazoline Receptors; Infusions, Intraventricular; Male; Mice; Microinjections; Motor Activity	2019