arbutin and decursin
arbutin has been researched along with decursin* in 1 studies
Other Studies
1 other study(ies) available for arbutin and decursin
Article | Year |
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Synthesis of (S)-(+)-decursin and its analogues as potent inhibitors of melanin formation in B16 murine melanoma cells.
We report the synthesis of a novel series of highly potent melanin inhibitors which were obtained through structural modification of an anticancer compound S-(+)-decursinol. The in vitro inhibitory potencies of the newly synthesized compounds were evaluated against α-MSH induced melanin production in B16 murine melanoma cells. Among the compounds evaluated, compounds 2, 3, 6b, 7a, 7b, 8a and 8b emerged as highly potent inhibitors of melanin production. Besides, these compounds demonstrated significantly low cytotoxicity. Topics: Animals; Benzopyrans; Butyrates; Cell Line, Tumor; Cell Proliferation; Melanins; Melanoma, Experimental; Mice; Molecular Structure; Stereoisomerism; Structure-Activity Relationship | 2010 |