arbutin and coumarin

arbutin has been researched along with coumarin* in 1 studies

Trials

1 trial(s) available for arbutin and coumarin

ArticleYear
Effectiveness and safety of a mixture of diosmin, coumarin and arbutin (Linfadren
    Clinical rehabilitation, 2019, Volume: 33, Issue:5

    Parallel-group randomized controlled trial.. Outpatient rehabilitation center.. A total of 60 outpatients (mean age 48.5 (standard deviation (SD) = 12.3) years) with post-trauma/surgery persistent hand edema.. Patients were randomized to either receive six-week conventional treatment plus Linfadren. Primary outcome was hand edema as measured by figure-of-eight method. Secondary outcomes were hand function, patient's overall perceived treatment effectiveness and rescue medication request. Tolerability of Linfadren. All patients completed the six-week program and 57 patients (95%) completed the three-month follow-up. At six weeks, the Study Group had significantly greater improvement in hand edema (423.3 (SD = 23.8) mm vs 439.4 (SD = 22.6) mm; P = 0.009) and upper limb function ( Quick Disabilities of Arm, Shoulder and Hand questionnaire: 23.6 (SD = 13.6) vs 37.7 (SD = 15.9); P = 0.005) compared to the Control Group. Moreover, the percentage of patients who perceived treatment as effective was significantly higher in the Study Group than in the Control Group both after treatment (70% vs 37%, P = 0.002) and at follow-up (77% vs 30%, P < 0.0001). The rescue medication request was not different between groups. No adverse events were recorded.

    Topics: Adult; Aged; Arbutin; Child; Combined Modality Therapy; Coumarins; Diosmin; Drug Combinations; Edema; Female; Hand; Hand Injuries; Humans; Male; Middle Aged; Patient Satisfaction; Physical Therapy Modalities; Postoperative Complications

2019