Compounds > arachidonic acid 5-hydroperoxide

arachidonic acid 5-hydroperoxide and leukotriene b4

arachidonic acid 5-hydroperoxide has been researched along with leukotriene b4 in 36 studies

*Leukotriene B4: The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990) [MeSH]

Research

Studies (36)

Timeframe	Studies, this research(%)	All Research%
pre-1990	20 (55.56)	18.7374
1990's	12 (33.33)	18.2507
2000's	3 (8.33)	29.6817
2010's	0 (0.00)	24.3611
2020's	1 (2.78)	2.80

Authors

Authors	Studies
Cho, H; Cho, S; Hwang, SW; Jung, J; Kang, CJ; Kim, D; Kwak, J; Lee, SY; Min, KH; Oh, U; Suh, YG	1
Gut, J; Huwyler, J; Jedlitschky, G; Keppler, D	1
Bürgin, M; Gut, J; Huwyler, J; Zeugin, T	1
Gut, J; Huwyler, J	1
Gut, J; Trudell, JR	1
Izumi, T; Kitamura, S; Ohishi, N; Seyama, Y; Shimizu, T	1
Hatzelmann, A; Ullrich, V	1
Veldink, GA; Verhagen, J; Vliegenthart, JF; Walstra, P	1
Gut, J; Jamieson, GC; Trudell, JR	1
Goldman, DW; Gut, J; Trudell, JR	1
Reynolds, CH	1
Kaliner, MA; Lundgren, JD; Shelhamer, JH	1
Hirai, A; Saito, H; Tahara, K; Tamura, Y; Terano, T; Yoshida, S	1
Borbe, HO; Fischer, H; Kuhl, P; Parnham, MJ; Römer, A	1
Kragballe, K; Voorhees, JJ	1
Anker, R; Quezada, A	1
Izumi, T; Rådmark, O; Samuelsson, B; Seyama, Y; Shimizu, T; Tadokoro, K	1
Sviatkina, OB; Vel'tishchev, IuE	1
Corey, EJ	1
Ford-Hutchinson, AW; Rackham, A; Rokach, J; Roy, S; Zamboni, R	1
Francis, DM; Greaves, MW; Kozuka, T	1
Goetzl, EJ; Kay, AB; Moqbel, R; Sass-Kuhn, SP	1
Bösterling, B; Trudell, JR	1
McCall, CE; O'Flaherty, JT; Thomas, MJ; Wykle, RL	1
Beilecke, U; Fusenig, NE; Goerig, M; Janssen-Timmen, U; Lehmann, WD; Rådmark, O; Rosenbach, T; Samuelsson, B; Stark, HJ; Vickers, P	1
Brideau, C; Chan, C; Falgueyret, JP; Guay, J; Hutchinson, JH; Jones, TR; Lépine, C; Macdonald, D; McFarlane, CS; Riendeau, D	1
Li, C; Mancini, JA; Vickers, PJ	1
Chilton, FH; Hubbard, WC; Sung, CM; Winkler, JD	1
Blair, IA; Christman, BW; Christman, JW; Dworski, R; Prakash, C	1
Brideau, C; Chan, CC; Chauret, N; Delorme, D; Desmarais, S; Dubé, D; Ducharme, Y; Falgueyret, JP; Fortin, R; Girard, Y; Guay, J; Hamel, P; Jones, TR; Lépine, C; Li, C; McAuliffe, M; McFarlane, CS; Nicoll-Griffith, DA; Riendeau, D; Yergey, JA	1
Kiesel, L; Przylipiak, A; Przylipiak, J; Rabe, T; Runnebaum, B	1
Horiuchi, M; Mita, S; Miyake, Y; Tsuji, F	1
Chiba, N; Imai, H; Nakagawa, Y	1
Haeggström, JZ; Kull, F; Lind, B; Ohlson, E	1
Devery, R; Miller, A; Stanton, C	1
Bu, W; Eckenhoff, RG; Okuno, T; Yokomizo, T; Yuki, K	1

Reviews

3 review(s) available for arachidonic acid 5-hydroperoxide and leukotriene b4

Article	Year
The role of eicosanoids in respiratory mucus hypersecretion. Annals of allergy, 1985, Volume: 55, Issue:1 Topics: Animals; Arachidonic Acids; Aspirin; Asthma; Bronchial Diseases; Cells, Cultured; Fatty Acids, Unsaturated; Humans; Leukotriene B4; Leukotrienes; Mucoproteins; Mucus; Prostaglandins; Thromboxanes	1985
[New mediators of allergy and inflammation of a lipid nature]. Voprosy meditsinskoi khimii, 1984, Volume: 30, Issue:6 Topics: Animals; Arachidonic Acids; Calcium; Carboxy-Lyases; Humans; Hypersensitivity; Inflammation; Leukotriene B4; Leukotrienes; Methyltransferases; Muscle, Smooth; Oxidation-Reduction; Phospholipases; SRS-A	1984
Chemical studies on slow reacting substances/leukotrienes. Experientia, 1982, Nov-15, Volume: 38, Issue:11 Topics: Animals; Arachidonic Acids; Asthma; Autacoids; Chemical Phenomena; Chemistry; Humans; Hydroxyeicosatetraenoic Acids; Hypersensitivity; Leukotriene A4; Leukotriene B4; Leukotriene E4; Leukotrienes; Lipoxygenase Inhibitors; Macrophages; Mast Cells; Molecular Conformation; Neutrophils; SRS-A; Stereoisomerism; Structure-Activity Relationship	1982

Other Studies

33 other study(ies) available for arachidonic acid 5-hydroperoxide and leukotriene b4

Article	Year
Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances. Proceedings of the National Academy of Sciences of the United States of America, 2000, May-23, Volume: 97, Issue:11 Topics: Animals; Capsaicin; Cell Line; Cells, Cultured; Dinoprostone; Eicosanoids; Ganglia, Spinal; Humans; Hydroxyeicosatetraenoic Acids; Inflammation; Ion Channel Gating; Leukotriene B4; Leukotrienes; Ligands; Lipid Peroxides; Lipoxygenase; Molecular Structure; Neurons, Afferent; Prostaglandin D2; Prostaglandin H2; Prostaglandins H; Rats; Receptors, Drug; Structure-Activity Relationship	2000
Halothane metabolism. Impairment of hepatic omega-oxidation of leukotrienes in vivo and in vitro. European journal of biochemistry, 1992, Jun-15, Volume: 206, Issue:3 Topics: Animals; Cytochrome P-450 Enzyme System; Halothane; Isoenzymes; Kinetics; Leukotriene B4; Leukotriene E4; Leukotrienes; Liver; Male; Microsomes, Liver; Oxidation-Reduction; Rats; Rats, Inbred Strains; SRS-A; Trifluoroacetic Acid	1992
Transformation of 5-hydroperoxyeicosatetraenoic acid into dihydroxy- and cysteinyl-leukotrienes by rat hepatocytes: effects of glutathione. Molecular pharmacology, 1991, Volume: 39, Issue:3 Topics: Animals; Cell-Free System; Chromatography, High Pressure Liquid; Glutathione; Glutathione Peroxidase; Kupffer Cells; Leukotriene B4; Leukotrienes; Liver; Male; Rats; Rats, Inbred Strains; SRS-A; Thiomalates; Time Factors	1991
Single-step organic extraction of leukotrienes and related compounds and their simultaneous analysis by high-performance liquid chromatography. Analytical biochemistry, 1990, Aug-01, Volume: 188, Issue:2 Topics: 1-Propanol; Animals; Chromatography, High Pressure Liquid; Glutathione; Hydrogen-Ion Concentration; Hydroxyeicosatetraenoic Acids; Leukotriene A4; Leukotriene B4; Leukotrienes; Liver; Male; Methylene Chloride; Prostaglandins B; Rats; Rats, Inbred Strains; SRS-A	1990
Properties of enzymes in hepatocytes that convert 5-HPETE or LTA4 into LTB4. Free radical biology & medicine, 1989, Volume: 7, Issue:3 Topics: Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Binding Sites; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Endoplasmic Reticulum; Free Radicals; Leukotriene A4; Leukotriene B4; Leukotrienes; Lipoxygenase Inhibitors; Liver; Male; Models, Biological; Molecular Structure; Oxygen; Rats; Rats, Inbred F344	1989
Biosynthesis and further transformations of leukotriene A4. Advances in prostaglandin, thromboxane, and leukotriene research, 1987, Volume: 17A Topics: Animals; Arachidonic Acids; Epoxide Hydrolases; Glutathione Transferase; Guinea Pigs; Leukotriene A4; Leukotriene B4; Leukotrienes; Tissue Distribution	1987
Regulation of 5-lipoxygenase activity by the glutathione status in human polymorphonuclear leukocytes. European journal of biochemistry, 1987, Nov-16, Volume: 169, Issue:1 Topics: Adult; Arachidonate 5-Lipoxygenase; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Chromatography, High Pressure Liquid; Diamide; Dinitrochlorobenzene; Glutathione; Humans; Hydroxyeicosatetraenoic Acids; Kinetics; Leukotriene B4; Leukotrienes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils	1987
12-Lipoxygenase from bovine polymorphonuclear leukocytes, an enzyme with leukotriene A4-synthase activity. Biochemical and biophysical research communications, 1987, Nov-30, Volume: 149, Issue:1 Topics: Animals; Arachidonate 12-Lipoxygenase; Arachidonate Lipoxygenases; Arachidonic Acids; Cattle; Cell-Free System; Hydroxyeicosatetraenoic Acids; Leukotriene A4; Leukotriene B4; Leukotrienes; Neutrophils	1987
Leukotriene biosynthesis: direct chemical ionization mass spectrometry of underivatized arachidonic acid metabolites. Biomedical & environmental mass spectrometry, 1988, May-01, Volume: 15, Issue:9 Topics: Arachidonic Acids; Humans; In Vitro Techniques; Leukotriene A4; Leukotriene B4; Leukotrienes; Lipid Peroxides; Mass Spectrometry; Microsomes, Liver	1988
Conversion of 5-hydroperoxyeicosatetraenoic acid into leukotriene B4 by rat hepatocytes: a novel cellular source for leukotriene B4. Molecular pharmacology, 1988, Volume: 34, Issue:3 Topics: Animals; Arachidonic Acids; Diethylcarbamazine; In Vitro Techniques; Leukotriene A4; Leukotriene B4; Leukotrienes; Lipoxygenase Inhibitors; Liver; Male; Mass Spectrometry; Rats; Rats, Inbred Strains; Receptors, Immunologic; Receptors, Leukotriene B4	1988
5-Lipoxygenase and leukotriene synthesis: effects of calcium ions and of inhibitors. Prostaglandins, 1988, Volume: 36, Issue:1 Topics: Arachidonate 5-Lipoxygenase; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Calcium; Humans; Hydrogen-Ion Concentration; Leukotriene B4; Leukotrienes	1988
Involvement of 5-lipoxygenase metabolites in ACTH-stimulated corticosteroidogenesis in rat adrenal glands. Prostaglandins, 1985, Volume: 30, Issue:5 Topics: Adrenal Cortex; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Animals; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Benzoquinones; Cyclic AMP; Dose-Response Relationship, Drug; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Indomethacin; Leukotriene B4; Leukotrienes; Lipoxygenase; Male; Quinones; Rats; Rats, Inbred Strains	1985
Selective inhibition of leukotriene B4 formation by Ebselen: a novel approach to antiinflammatory therapy. Agents and actions, 1986, Volume: 17, Issue:3-4 Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acids; Azoles; Blood Platelets; Humans; In Vitro Techniques; Isoindoles; Leukocytes; Leukotriene A4; Leukotriene B4; Leukotrienes; Organoselenium Compounds; Selenium; Swine	1986
Arachidonic acid in psoriasis. Pathogenic role and pharmacological regulation. Acta dermato-venereologica. Supplementum, 1985, Volume: 120 Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Arachidonic Acid; Arachidonic Acids; Fish Oils; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Leukotrienes; Lipoxygenase; Lipoxygenase Inhibitors; Psoriasis; Skin; SRS-A	1985
[Derivatives of arachidonic acid. I. Structure, biosynthesis and biological role]. Boletin medico del Hospital Infantil de Mexico, 1986, Volume: 43, Issue:4 Topics: Airway Resistance; Arachidonic Acids; Chemotaxis, Leukocyte; Humans; Hydroxyeicosatetraenoic Acids; Inflammation; Leukotriene B4; Leukotrienes; Lipoxygenase; Molecular Conformation; Prostaglandin-Endoperoxide Synthases; Prostaglandins; SRS-A; Terminology as Topic; Vasomotor System	1986
Characterization of leukotriene A4 synthase from murine mast cells: evidence for its identity to arachidonate 5-lipoxygenase. Proceedings of the National Academy of Sciences of the United States of America, 1986, Volume: 83, Issue:12 Topics: Animals; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Cell Line; Hot Temperature; Leukotriene B4; Leukotrienes; Lipoxygenase; Mast Cells; Mice	1986
Comparative biological activities of synthetic leukotriene B4 and its omega-oxidation products. Prostaglandins, 1983, Volume: 25, Issue:1 Topics: Animals; Arachidonic Acids; Capillary Permeability; Cell Aggregation; Exudates and Transudates; Guinea Pigs; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Isomerism; Leukotriene B4; Leukotrienes; Male; Muscle Contraction; Neutrophils; Oxidation-Reduction; Rabbits; Rats	1983
Arachidonic acid metabolites and the skin. Annals of the Academy of Medicine, Singapore, 1983, Volume: 12, Issue:1 Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Arachidonic Acids; Cyclic AMP; Humans; Leukotriene B4; Leukotrienes; Mast Cells; Prostaglandins; Psoriasis; Skin; Skin Diseases; SRS-A; Ultraviolet Rays	1983
Enhancement of neutrophil- and eosinophil-mediated complement-dependent killing of schistosomula of Schistosoma mansoni in vitro by leukotriene B4. Clinical and experimental immunology, 1983, Volume: 52, Issue:3 Topics: Arachidonic Acids; Complement System Proteins; Cytotoxicity, Immunologic; Eosinophils; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Leukotrienes; Neutrophils; Schistosoma mansoni; SRS-A	1983
Evidence for leukotriene A4 as an intermediate in the conversion of 5-HPETE to leukotriene B4 catalyzed by cytochrome P-450. Biochemical and biophysical research communications, 1983, Sep-30, Volume: 115, Issue:3 Topics: Animals; Arachidonic Acids; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Isomerism; Kinetics; Leukotriene A4; Leukotriene B4; Leukotrienes; Microsomes, Liver; Phenobarbital; Rabbits	1983
Neutrophil degranulation responses to combinations of arachidonate metabolites and platelet-activating factor. Research communications in chemical pathology and pharmacology, 1984, Volume: 43, Issue:1 Topics: Arachidonic Acids; Cytoplasmic Granules; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene A4; Leukotriene B4; Leukotrienes; Neutrophils; Platelet Activating Factor; Stimulation, Chemical	1984
5-lipoxygenase expression in cultured human keratinocytes. Advances in prostaglandin, thromboxane, and leukotriene research, 1995, Volume: 23 Topics: Arachidonate 5-Lipoxygenase; Blotting, Western; Cells, Cultured; Gene Expression; Humans; Hydroxyeicosatetraenoic Acids; Keratinocytes; Kinetics; Leukotriene B4; Leukotrienes; RNA, Messenger; Time Factors	1995
Thiopyrano[2,3,4-cd]indoles as 5-lipoxygenase inhibitors: synthesis, biological profile, and resolution of 2-[2-[1-(4-chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5 -dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]ethoxy]butanoic acid. Journal of medicinal chemistry, 1994, Apr-15, Volume: 37, Issue:8 Topics: Animals; Bronchoconstriction; Calcimycin; Chromatography, High Pressure Liquid; Humans; Indoles; Leukotriene B4; Leukotrienes; Lipoxygenase Inhibitors; Male; Molecular Structure; Pyridines; Rats; Rats, Sprague-Dawley; Saimiri; Sheep; Stereoisomerism; Structure-Activity Relationship; Swine	1994
5-Lipoxygenase activity in the human pancreas. Journal of lipid mediators, 1993, Volume: 8, Issue:3 Topics: 5-Lipoxygenase-Activating Proteins; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Blotting, Western; Carrier Proteins; Chromatography, High Pressure Liquid; Female; Humans; Leukotriene A4; Leukotriene B4; Leukotrienes; Male; Membrane Proteins; Middle Aged; Pancreas; Subcellular Fractions	1993
Influence of arachidonic acid on indices of phospholipase A2 activity in the human neutrophil. The Biochemical journal, 1993, May-01, Volume: 291 ( Pt 3) Topics: Arachidonic Acid; Calcimycin; Fatty Acids; Fatty Acids, Nonesterified; Gas Chromatography-Mass Spectrometry; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Leukotrienes; Neutrophils; Phospholipases A; Phospholipases A2; Platelet Activating Factor	1993
Prostaglandin E2 limits arachidonic acid availability and inhibits leukotriene B4 synthesis in rat alveolar macrophages by a nonphospholipase A2 mechanism. Journal of immunology (Baltimore, Md. : 1950), 1993, Aug-15, Volume: 151, Issue:4 Topics: Animals; Arachidonic Acid; Calcimycin; Dinoprostone; Leukotriene B4; Leukotrienes; Macrophages, Alveolar; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Rats	1993
Dioxabicyclooctanyl naphthalenenitriles as nonredox 5-lipoxygenase inhibitors: structure-activity relationship study directed toward the improvement of metabolic stability. Journal of medicinal chemistry, 1996, Sep-27, Volume: 39, Issue:20 Topics: Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Benzofurans; Bronchoconstriction; Drug Stability; Humans; Leukotriene B4; Leukotrienes; Lipoxygenase Inhibitors; Male; Microsomes, Liver; Molecular Structure; Naphthalenes; Neutrophils; Nitriles; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Saimiri; Structure-Activity Relationship	1996
Inhibitory effect of leukotrienes on luteinizing hormone release. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 1997, Volume: 11, Issue:3 Topics: Animals; Arachidonic Acid; Cells, Cultured; Female; Gonadotropin-Releasing Hormone; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Leukotriene C4; Leukotriene D4; Leukotriene E4; Leukotrienes; Luteinizing Hormone; Perfusion; Pituitary Gland, Anterior; Rats; Rats, Sprague-Dawley; Time Factors	1997
Involvement of leukotriene B4 in murine dermatitis models. Biochemical pharmacology, 1998, Feb-01, Volume: 55, Issue:3 Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Cysteine; Dermatitis; Enzyme Inhibitors; Epoxide Hydrolases; Leukotriene B4; Leukotrienes; Male; Mice; Mice, Inbred ICR	1998
Determination of 5-hydroperoxyeicosatetraenoic acid produced in rat basophilic leukemia cell line RBL-2H3 by high-performance liquid chromatography with chemiluminescence detection. Journal of chromatography. B, Biomedical sciences and applications, 1999, May-14, Volume: 728, Issue:1 Topics: Animals; Calcimycin; Calibration; Chromatography, High Pressure Liquid; Leukemia, Basophilic, Acute; Leukotriene B4; Leukotrienes; Luminescent Measurements; Malates; Rats; Tumor Cells, Cultured	1999
Saccharomyces cerevisiae leukotriene A4 hydrolase: formation of leukotriene B4 and identification of catalytic residues. Biochemistry, 2001, Oct-23, Volume: 40, Issue:42 Topics: Amino Acid Sequence; Animals; Binding Sites; Catalytic Domain; Enzyme Inhibitors; Epoxide Hydrolases; Escherichia coli; Glutamic Acid; Humans; Hydrolysis; Leukotriene A4; Leukotriene B4; Leukotrienes; Molecular Sequence Data; Mutagenesis, Site-Directed; Phenylalanine; Recombinant Proteins; Saccharomyces cerevisiae; Spodoptera; Tyrosine; Zinc	2001
Modulation of arachidonic acid distribution by conjugated linoleic acid isomers and linoleic acid in MCF-7 and SW480 cancer cells. Lipids, 2001, Volume: 36, Issue:10 Topics: Arachidonic Acid; Breast Neoplasms; Carbon Radioisotopes; Cell Survival; Colonic Neoplasms; Dinoprost; Dinoprostone; Humans; Leukotriene B4; Leukotrienes; Linoleic Acid; Prostaglandin D2; Tumor Cells, Cultured	2001
The role of propofol hydroxyl group in 5-lipoxygenase recognition. Biochemical and biophysical research communications, 2020, 05-14, Volume: 525, Issue:4 Topics: Anesthetics, Intravenous; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Binding Sites; Calcimycin; Calcium Ionophores; HEK293 Cells; Humans; Leukotriene B4; Leukotrienes; Lipoxygenase Inhibitors; Molecular Docking Simulation; Mutagenesis; Propofol; Protein Conformation; Structure-Activity Relationship	2020