arabinofuranosyluracil has been researched along with sorivudine in 88 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 14 (15.91) | 18.7374 |
1990's | 64 (72.73) | 18.2507 |
2000's | 8 (9.09) | 29.6817 |
2010's | 2 (2.27) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Herrmann, G; Lin, JC; Pagano, JS; Reefschläger, J | 1 |
Bonner, DP; Field, AK; Huang, JL; Mitroka, JG; Olsen, S; Soike, K; Stouffer, B; Swerdel, M; Tu, JI; Tuomari, AV | 1 |
Ashida, N; Baba, M; Ikeda, T; Machida, H; Sakata, S; Shigeta, S | 1 |
Bowler, WA; Brodine, SK; Burgos, C; Chamberlin, CJ; LaRocco, A; Oldfield, EC; Sawyer, MH; Wallace, MR; Wu, YN | 1 |
Hayashi, K; Namazue, J; Ochiai, H; Ogino, S; Okuno, T; Shiraki, K; Takahashi, M; Yamanishi, K | 1 |
Machida, H; Suzutani, T | 1 |
Jagoda, E; Mantha, S; Ogan, M; Stouffer, B; Tsay, HM; Tu, JI; Turabi, N; Yost, F | 1 |
Ijichi, K; Machida, H; Takezawa, J | 1 |
Hamada, T; Hiraoka, A; Horiuchi, A; Kanamaru, A; Masaoka, T; Nagai, K; Niimura, M; Takahashi, M | 1 |
Machida, H; Watanabe, Y | 1 |
Daikoku, T; Nishiyama, Y; Yamada, Y; Yamamoto, N | 1 |
Hayashi, K; Machida, H; Nishitani, M; Suzutani, T | 1 |
Cohen, AI; Whigan, DB | 1 |
Honess, RW; Lacey, SF; Powell, KL; Purifoy, DJ; Suzutani, T | 1 |
Machida, H | 1 |
Ashida, N; Ijichi, K; Machida, H | 1 |
Honda, M; Ijichi, K; Machida, H; Niimura, M; Ohta, A | 1 |
Machida, H; Takezawa, J | 1 |
Machida, H; Nishitani, M | 1 |
Ashida, N; Ikeda, T; Machida, H | 1 |
Niimura, M | 1 |
Konno, K; Kumagai, M; Machida, H; Mori, S; Shigeta, S; Watanabe, Y; Yokota, T | 1 |
Azuma, M; Machida, H; Sakuma, T; Suzutani, T | 1 |
Machida, H; Sakuma, T; Suzutani, T | 1 |
Lin, JC; Machida, H | 1 |
Färber, I; Herrmann, G; Klinger, C; Reefschläger, J; Thiel, KD; Wutzler, P | 1 |
Rajcáni, J; Reefschläger, J | 1 |
Herrmann, G; Reefschläger, J; Thiel, KD; Wutzler, P | 1 |
Machida, H; Saneyoshi, M; Suzuki, S | 1 |
Gräf, M; Herrmann, G; Reefschläger, J; Töpke, H; Wutzler, P | 1 |
Ayisi, NK; De Clercq, E; Machida, H; Sacks, SL; Wall, RA; Wanklin, RJ | 1 |
Machida, H; Sakata, S | 1 |
Baskin, G; Cantrell, C; Gerone, P; Soike, KF | 1 |
Kuninaka, A; Machida, H; Sakata, S; Yoshino, H | 1 |
Sakuma, T | 1 |
Asai, T; Cho, R; Nakamura, H; Oh, H; Sato, H | 1 |
Burdge, DR; Gage, L; Lindley, JI; Sacks, SL; Voigt, R | 1 |
Kondo, S | 1 |
Bevilacqua, F; Collins, P; Darby, G; Davis-Poynter, N; Gower, D; Worrallo, J | 1 |
Foxworthy, D; Kemp, B; Pinnolis, MK | 1 |
Ashida, N; Kano, F; Machida, H; Nishitani, M; Sakata, S; Watanabe, Y | 1 |
Schuster, AE; Whigan, DB | 1 |
Easterbrook, P; Wood, MJ | 1 |
Ijichi, K; Komatsu, M; Machida, H; Mochizuki, K; Tanahashi, T; Torisaki, M; Yamashita, Y | 1 |
Kitada, K; Mochida, A; Nakamura, H; Omori, S | 1 |
Swinbanks, D | 1 |
Ashida, N; Machida, H; Nishitani, M | 1 |
Gnann, JW | 1 |
Honess, RW; Machida, H; Suzutani, T | 1 |
Ashida, N; Ijichi, K; Machida, H; Watanabe, Y | 1 |
Kawai, H; Suzutani, T; Yoshida, I | 1 |
Biron, KK; Phelps, WC; Talarico, CL | 1 |
Ashida, N; Ijichi, K; Machida, H; Varia, S | 1 |
Whitley, RJ | 2 |
Arvin, AM; Bowler, WA; Chamberlin, CJ; Colopy, MW; Harkins, J; LaRocco, A; Oldfield, EC; Sawyer, MH; Wallace, MR | 1 |
Hirsch, HH; Hirschel, B; Miner, R; von Gunten, S; Wintsch, J; Wunderli, W | 1 |
Azuma, M; Koyano, S; Suzutani, T; Yoshida, I | 1 |
Akiyama, H; Imaoka, T; Kawaguchi, T; Miyauchi, S; Motoyama, M; Odomi, M; Okada, T | 1 |
Ikeda, K; Kawaguchi, K; Nagayama, S; Nakamura, Y; Nishiyama, T; Ogura, K; Ogura, Y; Okuda, H; Watabe, T; Yamaguchi, S | 1 |
Watabe, T | 1 |
Cassady, KA; Whitley, RJ | 1 |
Akimoto, S; Kataoka, K; Kinouchi, T; Matsuda, Y; Nakayama, H; Ohnishi, Y | 1 |
Ikeda, K; Kawaguchi, Y; Nagayama, S; Nakamura, Y; Nishiyama, T; Ogura, K; Okuda, H; Watabe, T; Yamaguchi, S | 1 |
Diasio, RB; Haworth, S; Lee, PC; McCrary, MM; Olsen, SJ; Raymond, R; Tyring, SK; Yan, J | 1 |
Boag, F; Bodsworth, NJ; Borleffs, JC; Burdge, D; Colebunders, R; DeHertogh, D; Evans, BA; Généreux, M; Modai, J; Pacelli, L; Thomas, M; Thomis, J | 1 |
Jurima-Romet, M; Li, AP | 1 |
Ogura, K; Okuda, H; Watabe, T | 1 |
Arakawa, K; Fukushima, M; Kato, A; Kawaguchi, Y; Nagayama, S; Nishiyama, T; Ogura, K; Okuda, H; Takubo, H; Watabe, T | 1 |
Ashida, N; Machida, H; Sakata, S | 1 |
Baum, KF; Borucki, MJ; Cloud, GA; Crumpacker, CS; DeHertogh, DA; Gnann, JW; Joseph, WP; Lalezari, JP; Mertz, GJ; Sherrill, LC; Smith, JA; Soong, SJ; Steigbigel, RT; Tyring, SK; Whitley, RJ | 1 |
Wutzler, P | 1 |
Diasio, RB | 1 |
Chern, KC; Conrad, D; Holland, GN; Holsclaw, DS; Margolis, TP; Schwartz, LK | 1 |
Kato, A; Ogura, K; Okuda, H; Takubo, H; Watabe, T | 1 |
Bartz-Schmidt, KU; Heimann, K; Kirchhof, B; Rosenthal, G; Walter, P | 1 |
Balzarini, J; Baudson, N; Calberg-Bacq, CM; Cool, V; De Leval, L; Debrus, S; Degrève, B; Grignet-Debrus, C; Velu, T | 1 |
Fujimura, A; Harada, K | 1 |
Desai, D; Jain, N; Janjikhel, R; Lang, B; Li, D | 1 |
Balzarinia, J; De Clercq, E; Degrève, B; Durini, E; Karlsson, A; Manfredini, S; Porcu, L; Zhu, C | 1 |
Bowers, M | 1 |
De Clercq, E; Naesens, L | 1 |
Nishiyama, T; Ogura, K; Watabe, T | 1 |
Andrei, G; De Clercq, E; Snoeck, R | 1 |
Konagaya, A; Satou, K; Yoshikawa, S | 1 |
Li-Wan-Po, A | 1 |
Andrei, G; Coen, N; Duraffour, S; Snoeck, R; Topalis, D | 1 |
11 review(s) available for arabinofuranosyluracil and sorivudine
Article | Year |
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Apoptosis by antitumor agents and other factors in relation to cell cycle checkpoints.
Topics: Antineoplastic Agents; Antiviral Agents; Apoptosis; Arabinofuranosyluracil; Cell Cycle; G1 Phase; G2 Phase; Humans | 1995 |
Successors to acyclovir.
Topics: 2-Aminopurine; Acyclovir; Antiviral Agents; Arabinofuranosyluracil; Chickenpox; Drug Resistance, Microbial; Famciclovir; Herpes Simplex; Herpes Zoster; Humans; Valacyclovir; Valine | 1994 |
New antivirals with activity against varicella-zoster virus.
Topics: 2-Aminopurine; Acyclovir; Antiviral Agents; Arabinofuranosyluracil; Drugs, Investigational; Famciclovir; Herpes Zoster; Humans; Prodrugs; Valacyclovir; Valine | 1994 |
Sorivudine: a promising drug for the treatment of varicella-zoster virus infection.
Topics: Antiviral Agents; Arabinofuranosyluracil; Herpes Zoster; Humans | 1995 |
Sorivudine: a potent inhibitor of varicella zoster virus replication.
Topics: Adult; Animals; Antiviral Agents; Arabinofuranosyluracil; Herpesvirus 3, Human; Humans; Virus Replication | 1996 |
New therapeutic approaches to the alphaherpesvirus infections.
Topics: 2-Aminopurine; Acyclovir; Alphaherpesvirinae; Antibodies, Monoclonal; Arabinofuranosyluracil; Cidofovir; Cytosine; Famciclovir; Guanine; Herpesviridae Infections; Humans; Organophosphonates; Organophosphorus Compounds; Valacyclovir; Valine | 1997 |
Overview: pharmacokinetic drug-drug interactions.
Topics: Arabinofuranosyluracil; Contraceptives, Oral; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Heart Diseases; Humans; Isoenzymes; Liver; Pharmacokinetics; Pregnancy; Pregnancy, Unwanted; Terfenadine | 1997 |
[Lethal drug interactions of the new antiviral, sorivudine, with anticancer prodrugs of 5-fluorouracil].
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antiviral Agents; Arabinofuranosyluracil; Dihydrouracil Dehydrogenase (NADP); Drug Interactions; Fluorouracil; Humans; NADP; Oxidoreductases; Prodrugs; Rats | 1997 |
Antiviral therapy of herpes simplex and varicella-zoster virus infections.
Topics: 2-Aminopurine; Acyclovir; Administration, Oral; Antiviral Agents; Arabinofuranosyluracil; Bromodeoxyuridine; Chickenpox; Drug Resistance, Microbial; Encephalitis, Viral; Famciclovir; Herpes Genitalis; Herpes Labialis; Herpes Simplex; Herpes Zoster; Humans; Immunocompromised Host; Prodrugs; Simplexvirus; Valacyclovir; Valine | 1997 |
Recent developments in herpesvirus therapy.
Topics: 2-Aminopurine; Acyclovir; Antiviral Agents; Arabinofuranosyluracil; Bromodeoxyuridine; Cidofovir; Clinical Trials as Topic; Cytosine; Famciclovir; Foscarnet; Ganciclovir; Guanine; Herpesviridae Infections; Humans; Organophosphonates; Organophosphorus Compounds; Thionucleotides; Valacyclovir; Valine | 2001 |
[Molecular toxicological mechanism of the lethal interactions of the new antiviral drug, sorivudine, with 5-fluorouracil prodrugs and genetic deficiency of dihydropyrimidine dehydrogenase].
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Bromouracil; Dihydrouracil Dehydrogenase (NADP); Drug Interactions; Drug Therapy, Combination; Fluorouracil; Humans; NADP; Oxidoreductases; Prodrugs; Rats | 2002 |
8 trial(s) available for arabinofuranosyluracil and sorivudine
Article | Year |
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Detection of varicella-zoster virus DNA in the oropharynx and blood of patients with varicella.
Topics: Adult; Antiviral Agents; Arabinofuranosyluracil; Base Sequence; Cells, Cultured; Chickenpox; DNA, Viral; Herpesvirus 3, Human; Humans; Male; Molecular Sequence Data; Oropharynx; Polymerase Chain Reaction | 1992 |
Clinical effect of BV-araU on varicella-zoster virus infection in immunocompromised patients with haematological malignancies.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antiviral Agents; Arabinofuranosyluracil; Chickenpox; Child; Hematologic Diseases; Herpesvirus 3, Human; Humans; Immune Tolerance; Middle Aged; Remission Induction | 1991 |
A double-blind clinical study in patients with herpes zoster to establish YN-72 (Brovavir) dose.
Topics: Adult; Analgesia; Antiviral Agents; Arabinofuranosyluracil; Dose-Response Relationship, Drug; Double-Blind Method; Herpes Zoster; Humans; Placebos | 1990 |
Manual and automated determination of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil and its metabolite (E)-5-(2-bromovinyl)uracil in urine.
Topics: Antiviral Agents; Arabinofuranosyluracil; Autoanalysis; Bromouracil; Chromatography, High Pressure Liquid; Humans; Robotics | 1995 |
Treatment of adult varicella with sorivudine: a randomized, placebo-controlled trial.
Topics: Administration, Oral; Adult; Antiviral Agents; Arabinofuranosyluracil; Chickenpox; Cohort Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Herpesvirus 3, Human; Hospitals, Military; Humans; Immunocompetence; Male; Placebos; Polymerase Chain Reaction; Skin | 1996 |
The effect of sorivudine on dihydropyrimidine dehydrogenase activity in patients with acute herpes zoster.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Analysis of Variance; Antiviral Agents; Arabinofuranosyluracil; Bromouracil; Chromatography, High Pressure Liquid; Dihydrouracil Dehydrogenase (NADP); Female; Herpes Zoster; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Oxidoreductases; Software; Uracil | 1997 |
Evaluation of sorivudine (BV-araU) versus acyclovir in the treatment of acute localized herpes zoster in human immunodeficiency virus-infected adults. The Multinational Sorivudine Study Group.
Topics: Acute Disease; Acyclovir; Adolescent; Adult; Antiviral Agents; Arabinofuranosyluracil; Double-Blind Method; Herpes Zoster; HIV Infections; Humans; Middle Aged; Patient Compliance | 1997 |
Sorivudine versus acyclovir for treatment of dermatomal herpes zoster in human immunodeficiency virus-infected patients: results from a randomized, controlled clinical trial. Collaborative Antiviral Study Group/AIDS Clinical Trials Group, Herpes Zoster St
Topics: Acyclovir; Adolescent; Adult; Aged; AIDS-Related Opportunistic Infections; Antiviral Agents; Arabinofuranosyluracil; Double-Blind Method; Female; Herpes Zoster; Humans; Male; Middle Aged; Quality of Life; Recurrence; Treatment Outcome | 1998 |
69 other study(ies) available for arabinofuranosyluracil and sorivudine
Article | Year |
---|---|
Structure-activity relationship between (E)-5-(2-bromovinyl)- and 5-vinyl-1-beta-D-arabinofuranosyluracil (BV-araU, V-araU) in inhibition of Epstein-Barr virus replication.
Topics: Antiviral Agents; Arabinofuranosyluracil; Burkitt Lymphoma; DNA, Viral; Dose-Response Relationship, Drug; Herpesvirus 4, Human; Humans; Peptides; Structure-Activity Relationship; Tumor Cells, Cultured; Viral Proteins; Virus Replication | 1992 |
Oral bioavailability and anti-simian varicella virus efficacy of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil (BV-araU) in monkeys.
Topics: Administration, Oral; Adsorption; Animals; Antiviral Agents; Arabinofuranosyluracil; Biological Availability; Cells, Cultured; Chickenpox; Chlorocebus aethiops; Dose-Response Relationship, Drug; Female; Herpesvirus 3, Human; Male | 1992 |
In vitro drug combination of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil with anti-human immunodeficiency virus or anticancer nucleosides.
Topics: Antiviral Agents; Arabinofuranosyluracil; Bromouracil; Cytarabine; Drug Combinations; Floxuridine; Fluorouracil; Herpesvirus 3, Human; HIV-1; Humans; Zidovudine | 1992 |
Comparison of antiviral assay methods using cell-free and cell-associated varicella-zoster virus.
Topics: Acyclovir; Antiviral Agents; Arabinofuranosyluracil; Cell-Free System; DNA Replication; DNA, Viral; Herpesvirus 3, Human; Humans; Nucleic Acid Hybridization; Viral Plaque Assay; Virus Replication | 1992 |
Analysis of toxic and mutagenic activities of antiherpesvirus nucleosides against HeLa cells and herpes simplex virus type 1.
Topics: Acyclovir; Antiviral Agents; Arabinofuranosyluracil; Bromodeoxyuridine; Cell Death; Cell Division; HeLa Cells; Humans; Mutagens; Nucleosides; Simplexvirus; Vidarabine; Virus Replication | 1992 |
A radioimmunoassay for the new antiviral agent 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil.
Topics: Antiviral Agents; Arabinofuranosyluracil; Cross Reactions; Dose-Response Relationship, Drug; Humans; Indicators and Reagents; Isotope Labeling; Male; Radioimmunoassay; Reference Standards; Sensitivity and Specificity | 1992 |
Efficacy of oral treatment with BV-araU against cutaneous infection with herpes simplex type 1 in shaved mice.
Topics: Acyclovir; Administration, Oral; Animals; Antiviral Agents; Arabinofuranosyluracil; Disease Models, Animal; Drug Administration Schedule; Drug Evaluation, Preclinical; Female; Herpes Simplex; Immune Tolerance; Male; Mice; Mice, Inbred BALB C | 1992 |
Inhibition of DNA synthesis in varicella-zoster virus-infected cells by BV-araU.
Topics: Acyclovir; Antiviral Agents; Arabinofuranosyluracil; Cell Line; DNA, Viral; Dose-Response Relationship, Drug; Fibroblasts; Herpesvirus 3, Human; Humans; Lung; Simplexvirus; Thymidine | 1991 |
Susceptibility of a herpes simplex virus ribonucleotide reductase null mutant to deoxyribonucleosides and antiviral nucleoside analogs.
Topics: Acyclovir; Arabinofuranosyluracil; Deoxyribonucleosides; Ganciclovir; Hydroxyurea; Mutation; Nucleic Acid Synthesis Inhibitors; Ribonucleotide Reductases; Simplexvirus | 1991 |
Different antiviral potencies of BV-araU and related nucleoside analogues against herpes simplex virus type 1 in human cell lines and Vero cells.
Topics: Aminopterin; Animals; Antiviral Agents; Arabinofuranosyluracil; Cell Line; Drug Interactions; Floxuridine; Humans; Nucleosides; Simplexvirus; Thymidine; Vero Cells | 1991 |
High-performance liquid chromatographic determination of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil and its metabolite (E)-5-(2-bromovinyl)uracil in serum.
Topics: Antiviral Agents; Arabinofuranosyluracil; Chromatography, High Pressure Liquid; Humans; Reproducibility of Results; Spectrophotometry, Ultraviolet | 1991 |
Analysis of mutations in the thymidine kinase genes of drug-resistant varicella-zoster virus populations using the polymerase chain reaction.
Topics: Amino Acid Sequence; Animals; Antiviral Agents; Arabinofuranosyluracil; Base Sequence; Cell Line; Cloning, Molecular; DNA, Viral; Drug Resistance, Microbial; Electrophoresis, Polyacrylamide Gel; Herpesvirus 3, Human; Humans; Molecular Sequence Data; Mutation; Polymerase Chain Reaction; Thymidine Kinase; Vero Cells | 1991 |
Brovavir: its antiherpesviral activity and mode of action.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; DNA, Viral; Herpes Simplex; Herpesviridae Infections; Herpesvirus 3, Human; Immunosuppression Therapy; Mice; Mice, Inbred BALB C; Phosphorylation; Simplexvirus; Thymidine Kinase | 1990 |
Effect of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil against herpes simplex virus type 1 infection in immunosuppressed mice.
Topics: Acyclovir; Animals; Antiviral Agents; Arabinofuranosyluracil; Cyclophosphamide; Herpes Simplex; Immunosuppression Therapy; Male; Mice; Mice, Inbred ICR; Simplexvirus; Virus Replication | 1990 |
Antiviral potencies of BV-araU and related nucleoside analogues against varicella-zoster virus in different cell lines.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Herpesvirus 3, Human; Humans; Tumor Cells, Cultured; Vero Cells | 1990 |
Effect of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil (brovavir) on experimental infections in mice with herpes simplex virus type 1 strains of different degrees of virulence.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Brain; Encephalitis; Herpes Simplex; Male; Mice; Mice, Inbred ICR; Simplexvirus; Uridine; Virus Replication | 1990 |
Drug susceptibilities of isolates of varicella-zoster virus in a clinical study of oral brovavir.
Topics: Acyclovir; Adult; Antiviral Agents; Arabinofuranosyluracil; Cell Line; Herpes Zoster; Herpesvirus 3, Human; Humans; Uridine | 1990 |
Comparison of antiviral efficacies of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil (brovavir) and acyclovir against herpes simplex virus type 1 infections in mice.
Topics: Acyclovir; Animals; Antiviral Agents; Arabinofuranosyluracil; Disease Models, Animal; Drug Administration Routes; Encephalitis; Herpes Simplex; Humans; Male; Mice; Simplexvirus; Survival Rate | 1990 |
Mechanism of selective inhibition of varicella zoster virus replication by 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil.
Topics: Antiviral Agents; Arabinofuranosyluracil; Biological Transport; Cells, Cultured; DNA; DNA-Directed DNA Polymerase; DNA, Viral; Dose-Response Relationship, Drug; Herpesvirus 3, Human; Humans; In Vitro Techniques; Kinetics; Thymidine Kinase; Uridine; Virus Replication | 1989 |
Effects of various nucleosides on antiviral activity and metabolism of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil against herpes simplex virus types 1 and 2.
Topics: Antiviral Agents; Arabinofuranosyluracil; Chromatography, High Pressure Liquid; Nucleosides; Phosphorylation; Simplexvirus; Uridine | 1988 |
Efficacies of antiherpesvirus nucleosides against two strains of herpes simplex virus type 1 in Vero and human embryo lung fibroblast cells.
Topics: Acyclovir; Aminopterin; Animals; Antiviral Agents; Arabinofuranosyluracil; Arabinonucleosides; Dose-Response Relationship, Drug; Fibroblasts; Humans; Idoxuridine; Lung; Nucleosides; Simplexvirus; Thymidine; Vero Cells; Vidarabine | 1988 |
Comparison of two bromovinyl nucleoside analogs, 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil and E-5-(2-bromovinyl)-2'-deoxyuridine, with acyclovir in inhibition of Epstein-Barr virus replication.
Topics: Acyclovir; Arabinofuranosyluracil; Bromodeoxyuridine; DNA, Viral; Dose-Response Relationship, Drug; Drug Combinations; Herpesvirus 4, Human; Peptide Biosynthesis; Uridine; Virus Replication | 1988 |
Effect of (E)-5-(2-bromovinyl)- and 5-vinyl-1-beta-D-arabinofuranosyluracil on Epstein-Barr virus antigen expression in P3HR-1 cells: comparison with acyclovir.
Topics: Acyclovir; Antigens, Viral; Antiviral Agents; Arabinofuranosyluracil; Capsid Proteins; Cell Line; Herpesvirus 4, Human; Humans; Uridine | 1987 |
Efficacy of (E)-5-(2-bromovinyl)- and 5-vinyl-1-beta-D-arabinofuranosyluracil against acute herpes simplex virus keratitis and the establishment of latency: comparison with acyclovir and bromovinyldeoxyuridine.
Topics: Acute Disease; Acyclovir; Animals; Antiviral Agents; Arabinofuranosyluracil; Bromodeoxyuridine; Chemical Phenomena; Chemistry; Keratitis, Dendritic; Rabbits; Simplexvirus; Uridine | 1987 |
Treatment of experimental herpes simplex virus type 1 encephalitis in mice with (E)-5-(2-bromovinyl)- and 5-vinyl-1-beta-D-arabinofuranosyluracil: comparison with bromovinyl-deoxyuridine and acyclovir.
Topics: Acyclovir; Animals; Arabinofuranosyluracil; Bromodeoxyuridine; Cells, Cultured; Encephalitis; Female; Foscarnet; Herpes Simplex; Humans; Mice; Phosphonoacetic Acid; Simplexvirus; Uridine; Viral Plaque Assay | 1986 |
Antiviral activity of various 1-beta-D-arabinofuranosyl-E-5-halogenovinyluracils and E-5-bromovinyl-2'-deoxyuridine against salmon herpes virus, Oncorhynchus masou virus (OMV).
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Bromodeoxyuridine; Cell Line; Chromatography, High Pressure Liquid; DNA Polymerase II; Fish Diseases; Herpesviridae; Herpesviridae Infections; Nucleic Acid Synthesis Inhibitors; Salmon; Uridine | 1987 |
Evaluation of (E)-5-(2-bromovinyl)- and 5-vinyl-1-beta-D-arabinofuranosyluracil (BrVaraU, VaraU) in the treatment of experimental herpes simplex virus type 1 keratitis in rabbits: comparison with (E)-5-(2-bromovinyl)-2'-deoxyuridine (BrVUdR).
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Bromodeoxyuridine; Drug Evaluation, Preclinical; Keratitis, Dendritic; Ophthalmic Solutions; Rabbits | 1988 |
Comparative metabolism of E-5-(2-bromovinyl)-2'-deoxyuridine and 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil in herpes simplex virus-infected cells.
Topics: Arabinofuranosyluracil; Bromodeoxyuridine; Cell Line; Chromatography, High Pressure Liquid; Fibroblasts; Herpes Simplex; Humans; Osteosarcoma; Uridine | 1987 |
In vitro and in vivo antiviral activity of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil (BV-araU) and related compounds.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Encephalitis; Herpes Simplex; Male; Mice; Simplexvirus; Uridine | 1984 |
Investigation of antiviral activity of 1-beta-D-arabinofuranosylthymine (ara-T) and 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil (BV-ara-U) in monkeys infected with simian varicella virus.
Topics: Animals; Arabinofuranosyluracil; Arabinonucleosides; Chickenpox; Chlorocebus aethiops; Herpesviridae Infections; Nervous System; Neurons; Thymidine; Uridine | 1984 |
Antiherpesviral and anticellular effects of 1-beta-D-arabinofuranosyl-E-5-(2-halogenovinyl) uracils.
Topics: Antiviral Agents; Arabinofuranosyluracil; Cell Division; Cell Line; Cells, Cultured; Cytopathogenic Effect, Viral; DNA, Viral; Simplexvirus; Uridine; Virus Replication | 1981 |
Strains of varicella-zoster virus resistant to 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Chlorocebus aethiops; Cloning, Molecular; DNA, Viral; Drug Resistance, Microbial; Embryo, Mammalian; Fibroblasts; Guinea Pigs; Herpesvirus 3, Human; Kidney; Thymidine; Thymidine Kinase; Uridine; Viral Plaque Assay; Virus Cultivation | 1984 |
Successful treatment of sorivudine-related agranulocytosis with granulocyte-colony stimulating factor.
Topics: Aged; Agranulocytosis; Antimetabolites, Antineoplastic; Antiviral Agents; Arabinofuranosyluracil; Female; Fluorouracil; Granulocyte Colony-Stimulating Factor; Humans; Male; Middle Aged | 1995 |
Sorivudine (BV-ara-U) for the treatment of complicated refractory varicella zoster virus infection in HIV-infected patients.
Topics: Adult; AIDS-Related Opportunistic Infections; Antiviral Agents; Arabinofuranosyluracil; Chickenpox; Drug Resistance; Herpesvirus 3, Human; Humans; Male | 1995 |
Construction of a herpes simplex virus/varicella-zoster virus (HSV/VZV) thymidine kinase recombinant with the pathogenic potential of HSV and a drug sensitivity profile resembling that of VZV.
Topics: Acyclovir; Animals; Antiviral Agents; Arabinofuranosyluracil; Base Sequence; Cytomegalovirus; Drug Evaluation, Preclinical; Ganciclovir; Herpes Simplex; Herpesvirus 1, Human; Herpesvirus 3, Human; Humans; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Promoter Regions, Genetic; Thymidine Kinase; Transformation, Genetic; Virulence; Virus Latency | 1995 |
Treatment of progressive outer retinal necrosis with sorivudine.
Topics: AIDS-Related Opportunistic Infections; Antiviral Agents; Arabinofuranosyluracil; Drug Therapy, Combination; Ganciclovir; Herpes Zoster Ophthalmicus; Humans; Male; Middle Aged; Retinal Necrosis Syndrome, Acute | 1995 |
In vitro and in vivo anti-herpes viral activities and biological properties of CV-araU.
Topics: 3T3 Cells; Animals; Antiviral Agents; Arabinofuranosyluracil; Bromine; Cell Line; Chlorine; Encephalitis, Viral; Herpes Simplex; Humans; Male; Mice; Rats | 1994 |
Retinal toxicity and ocular kinetics of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil in rabbits.
Topics: Administration, Oral; Animals; Antiviral Agents; Arabinofuranosyluracil; Electroretinography; Eye; Half-Life; Injections; Rabbits; Retina | 1994 |
[Prevention of drug interactions and its countermeasure].
Topics: Animals; Arabinofuranosyluracil; Drug Interactions; Fluorouracil; Humans; Rats; Tegafur; Uracil | 1994 |
Deaths bring clinical trials under scrutiny in Japan.
Topics: Antiviral Agents; Arabinofuranosyluracil; Clinical Trials as Topic; Government Regulation; Humans; Japan; Poisoning; Professional Misconduct; Research Subjects; Therapeutic Human Experimentation | 1994 |
Effect of BV-araU and acyclovir on varicella-zoster virus replication with various length and timing of drug exposure.
Topics: Acyclovir; Antiviral Agents; Arabinofuranosyluracil; Cell Line; Cytopathogenic Effect, Viral; Dose-Response Relationship, Drug; Herpesvirus 3, Human; Humans; Time Factors; Viral Plaque Assay; Virus Replication | 1994 |
Blaming somebody else.
Topics: Antiviral Agents; Arabinofuranosyluracil; Drug Approval; Government Agencies; Herpes Zoster; Humans; Japan; Social Responsibility | 1994 |
Mechanism of inhibition of DNA synthesis by 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil.
Topics: Antiviral Agents; Arabinofuranosyluracil; Dideoxynucleotides; DNA Polymerase I; DNA, Bacterial; Escherichia coli; Thymine Nucleotides | 1993 |
Metabolism of 5'-ether prodrugs of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil in rats.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Biotransformation; Germ-Free Life; Klebsiella pneumoniae; Male; Prodrugs; Rats; Rats, Sprague-Dawley | 1993 |
Antiviral activity of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil against thymidine kinase negative strains of varicella-zoster virus.
Topics: Antiviral Agents; Arabinofuranosyluracil; Cells, Cultured; Herpesvirus 3, Human; Humans; Thymidine Kinase; Thymidylate Synthase | 1993 |
Analysis of the thymidine kinase genes from acyclovir-resistant mutants of varicella-zoster virus isolated from patients with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Acyclovir; AIDS-Related Opportunistic Infections; Amino Acid Sequence; Antiviral Agents; Arabinofuranosyluracil; Base Sequence; Drug Resistance, Microbial; Genes, Viral; Genetic Variation; Guanine; Herpesviridae Infections; Herpesvirus 3, Human; Humans; Molecular Sequence Data; Mutagenesis; Precipitin Tests; Sequence Analysis; Sequence Homology, Amino Acid; Thymidine Kinase; Viral Plaque Assay | 1993 |
Topical treatment with BV-araU of immunosuppressed and immunocompetent shaved mice cutaneously infected with herpes simplex virus type 1.
Topics: Administration, Topical; Animals; Antiviral Agents; Arabinofuranosyluracil; Cyclophosphamide; Dose-Response Relationship, Drug; Herpes Simplex; Immune Tolerance; Immunocompetence; Immunocompromised Host; Male; Mice; Mice, Inbred BALB C; Simplexvirus; Skin Diseases, Viral; Time Factors | 1993 |
Outer retinal necrosis due to a strain of varicella-zoster virus resistant to acyclovir, ganciclovir, and sorivudine.
Topics: Acyclovir; Adult; AIDS-Related Opportunistic Infections; Antiviral Agents; Arabinofuranosyluracil; Chickenpox; Drug Resistance, Microbial; Female; Ganciclovir; Herpesvirus 3, Human; Humans; Retinal Necrosis Syndrome, Acute | 1996 |
Analysis of phosphorylation pathways of antiherpesvirus nucleosides by varicella-zoster virus-specific enzymes.
Topics: Acyclovir; Antiviral Agents; Arabinofuranosyluracil; Cell Division; Cell Line; Cytomegalovirus; Ganciclovir; Guanine; Herpesviridae; Herpesvirus 3, Human; Humans | 1996 |
Leukopenia-inducing effect of a combination of a new 5-fluorouracil (5-FU)-derived drug, BOF-A2 (emitefur), with other 5-FU-derived drugs or BV-araU (sorivudine) in rats.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Arabinofuranosyluracil; Dose-Response Relationship, Drug; Drug Combinations; Fluorouracil; Leukopenia; Male; Rats; Rats, Sprague-Dawley | 1996 |
Lethal drug interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Antiviral Agents; Arabinofuranosyluracil; Area Under Curve; Bone Marrow Diseases; Bromouracil; Dihydrouracil Dehydrogenase (NADP); Drug Synergism; Female; Intestine, Small; Liver; Oxidoreductases; Rats; Rats, Wistar; Tegafur; Tissue Distribution | 1997 |
Strategic proposals for predicting drug-drug interactions during new drug development: based on sixteen deaths caused by interactions of the new antiviral sorivudine with 5-fluorouracil prodrugs.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Drug Design; Drug Interactions; Drug Therapy, Combination; Fluorouracil; Herpes Zoster; Humans; Japan; Prodrugs; Rats; Risk Assessment | 1996 |
Intestinal anaerobic bacteria hydrolyse sorivudine, producing the high blood concentration of 5-(E)-(2-bromovinyl)uracil that increases the level and toxicity of 5-fluorouracil.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Bacteria, Anaerobic; Bacteroides; Biotransformation; Bromouracil; Cecum; Fluorouracil; Gastric Mucosa; Gastrointestinal Contents; Intestinal Mucosa; Kidney; Liver; Male; Organ Specificity; Pentosyltransferases; Pyrimidine Phosphorylases; Rats; Rats, Sprague-Dawley | 1997 |
Lethal drug interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs.
Topics: Animals; Antimetabolites, Antineoplastic; Antiviral Agents; Arabinofuranosyluracil; Colony-Forming Units Assay; Dihydropyridines; Female; Oxidoreductases; Rats; Rats, Wistar; Tegafur; Tissue Distribution | 1997 |
Suicidal inactivation of human dihydropyrimidine dehydrogenase by (E)-5-(2-bromovinyl)uracil derived from the antiviral, sorivudine.
Topics: Antiviral Agents; Arabinofuranosyluracil; Bromouracil; Dihydrouracil Dehydrogenase (NADP); Dose-Response Relationship, Drug; Humans; Oxidoreductases; Recombinant Proteins | 1998 |
Metabolic fate of [3H]1-beta-D-arabinofuranosyl-5-[(E)-2-bromovinyl]uracil in herpes simplex virus type 1-infected cells.
Topics: Acyclovir; Antiviral Agents; Arabinofuranosyluracil; Cell Line; Centrifugation, Density Gradient; Chromatography, High Pressure Liquid; Deoxyribonucleases; DNA, Viral; Herpesvirus 1, Human; Humans; Oligodeoxyribonucleotides; Thymidine; Tritium | 1997 |
Sorivudine and 5-fluorouracil; a clinically significant drug-drug interaction due to inhibition of dihydropyrimidine dehydrogenase.
Topics: Antimetabolites, Antineoplastic; Antiviral Agents; Arabinofuranosyluracil; Dihydrouracil Dehydrogenase (NADP); Drug Interactions; Fluorouracil; Humans; Oxidoreductases | 1998 |
Chronic varicella-zoster virus epithelial keratitis in patients with acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Adult; Aged; Antiviral Agents; Arabinofuranosyluracil; CD4 Lymphocyte Count; Chronic Disease; Epithelium, Corneal; Herpes Zoster Ophthalmicus; Herpesvirus 3, Human; Humans; Keratitis, Dendritic; Male; Middle Aged; Retrospective Studies | 1998 |
A possible mechanism of eighteen patient deaths caused by interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs.
Topics: Animals; Antimetabolites, Antineoplastic; Antiviral Agents; Arabinofuranosyluracil; Bromouracil; Cause of Death; Dihydrouracil Dehydrogenase (NADP); Drug Interactions; Fluorouracil; Half-Life; Herpes Zoster; Humans; Liver; Neoplasms; Oxidoreductases; Prodrugs; Rats; Tissue Distribution | 1998 |
Failure of sorivudine therapy in progressive outer retinal necrosis caused by varicella zoster virus.
Topics: Adult; AIDS-Related Opportunistic Infections; Antibodies, Viral; Antiviral Agents; Arabinofuranosyluracil; Blindness; DNA, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Herpes Zoster Ophthalmicus; Herpesvirus 3, Human; Humans; Recurrence; Retinal Necrosis Syndrome, Acute; Treatment Failure | 1998 |
Comparative in vitro and in vivo cytotoxic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and its arabinosyl derivative, (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil (BVaraU), against tumor cells expressing either the Varicella zoster or
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Arabinofuranosyluracil; Breast Neoplasms; Bromodeoxyuridine; Female; Genetic Vectors; Herpesvirus 3, Human; Humans; Male; Mice; Mice, Nude; Rats; Rats, Inbred F344; Simplexvirus; Thymidine Kinase; Tumor Cells, Cultured | 2000 |
The need for improving information systems on drug interactions in Japan.
Topics: Adverse Drug Reaction Reporting Systems; Antimetabolites, Antineoplastic; Antiviral Agents; Arabinofuranosyluracil; Drug Interactions; Fluorouracil; Humans; Japan; Polypharmacy | 2000 |
Effects of light intensity, n-alcohols, water-soluble colorants, and solution viscosity on photoisomerization of sorivudine.
Topics: Alcohols; Antiviral Agents; Arabinofuranosyluracil; Coloring Agents; Isomerism; Light; Photochemistry; Solubility; Viscosity | 2001 |
2'-O-Acyl/alkyl-substituted arabinosyl nucleosides as inhibitors of human mitochondrial thymidine kinase.
Topics: Adenosine Triphosphate; Antineoplastic Agents; Antiviral Agents; Arabinofuranosyluracil; Arabinonucleosides; Binding, Competitive; Humans; Kinetics; Mitochondria; Phosphorus Radioisotopes; Phosphorylation; Thymidine; Thymidine Kinase; Tritium | 2001 |
Herpesviruses.
Topics: 2-Aminopurine; Acyclovir; Antiviral Agents; Arabinofuranosyluracil; Cidofovir; Complementary Therapies; Cytosine; Famciclovir; Foscarnet; Herpesviridae Infections; Organophosphonates; Organophosphorus Compounds; Valacyclovir; Valine; Viral Vaccines | 1995 |
In vitro selection of drug-resistant varicella-zoster virus (VZV) mutants (OKA strain): differences between acyclovir and penciclovir?
Topics: 2-Aminopurine; Acyclovir; Adenine; Antiviral Agents; Arabinofuranosyluracil; Bromodeoxyuridine; Cidofovir; Cytosine; DNA-Directed DNA Polymerase; Drug Resistance, Multiple, Viral; Drug Resistance, Viral; Foscarnet; Guanine; Herpesvirus 3, Human; Humans; Microbial Sensitivity Tests; Mutation; Organophosphonates; Phenotype; Selection, Genetic; Thymidine Kinase; Viral Proteins | 2004 |
Drug interaction ontology (DIO) for inferences of possible drug-drug interactions.
Topics: Arabinofuranosyluracil; Artificial Intelligence; Computational Biology; Dihydrouracil Dehydrogenase (NADP); Drug Interactions; Fluorouracil; Humans; Vocabulary, Controlled | 2004 |
The human genome: its modifications and interactions with those of the microbiome, and the practice of genomic medicine.
Topics: Arabinofuranosyluracil; Genome, Human; Genomics; Humans; Metagenome; Mitochondrial Diseases | 2013 |
Spectrum of activity and mechanisms of resistance of various nucleoside derivatives against gammaherpesviruses.
Topics: Acyclovir; Amino Acid Sequence; Animals; Antiviral Agents; Arabinofuranosyluracil; Bromodeoxyuridine; Cytarabine; DNA-Directed DNA Polymerase; Drug Resistance, Viral; Foscarnet; Ganciclovir; Guanine; Herpesvirus 4, Human; Herpesvirus 8, Human; Humans; Molecular Sequence Data; Protein Kinases; Rhadinovirus; Sequence Alignment; Structure-Activity Relationship; Thymidine Kinase; Viral Proteins | 2014 |