arabinofuranosyluracil and fialuridine

arabinofuranosyluracil has been researched along with fialuridine in 139 studies

Research

Studies (139)

Timeframe	Studies, this research(%)	All Research%
pre-1990	13 (9.35)	18.7374
1990's	61 (43.88)	18.2507
2000's	45 (32.37)	29.6817
2010's	18 (12.95)	24.3611
2020's	2 (1.44)	2.80

Authors

Authors	Studies
Drew, WL; King, D; Miner, R	1
King, DH	1
Balasubramaniam, NK; Gentry, GA; Veerisetty, V	1
Arias, C; Borrelli, E; Evans, RM; Heyman, RA; Sawchenko, PE	1
Borrelli, E; Evans, RM; Heyman, R; Hsi, M	1
Coen, DM; Fleming, HE; Leslie, LK; Retondo, MJ	1
Rollinson, EA	1
Bentele, B; Betz, JL; Mitchell, DH; Pizer, LI	1
Gill, MJ; Knaus, EE; Misra, HK; Samuel, J; Tovell, DR; Tyrrell, DL; Wiebe, LI; Yacyshyn, HP	1
Sougawa, M; Tanaka, Y; Yoshii, G	1
De Clercq, E; Groen, J; Osterhaus, AD	1
Cantrell, C; Gerone, PJ; Soike, KF	1
Chen, MS; Oshana, SC; Van Nostrand, M	1
Chou, TC; Fanucchi, MP; Fox, JJ; Watanabe, KA	1
Friedman-Kien, AE; Klein, RJ	1
Hsiung, GD; Mayo, DR	1
Colacino, JM; Staschke, KA	1
Conjeevaram, H; Di Bisceglie, AM; Fried, MW; Kleiner, D; Luciano, C; McKenzie, R; Park, Y; Sallie, R; Savarese, B; Tsokos, M	1
Swartz, MN	1
Dalakas, MC; Lewis, W	1
de Man, RA; Heijtink, RA; Niesters, HG; Schalm, SW	2
Marwick, C	2
Collins, JM; Katki, AG; Klecker, RW	1
Colacino, JM; Jaskunas, SR; Malcolm, SK	1
Bowsher, RR; Compton, JA; DeSante, KA; Hatcher, BL; Hyslop, DL; Jones, CD; Kirkwood, JA; Mabry, TE; Place, GD	1
Cui, L; Schinazi, RF; Sommadossi, JP; Yoon, S	1
Caldwell, SH; Dickson, RC; Ishitani, MB; McGory, RW; Oliveira, WM; Pruett, TL; Stevenson, WC	1
Caldwell, S; Dickson, R; Gaffey, M; Ishitani, M; Lobo, P; McCullough, C; Pruett, T; Stevenson, W	1
Stone, R	1
Brahams, D	1
Horton, R	1
Colacino, JM; Lewis, W; Meyer, RR; Perrino, FW; Simpson, JF	1
Bowsher, RR; Engelhardt, JA; Richardson, FC	1
Colacino, JM; Jones, CD; Mabry, TE; Staschke, KA	1
Jaenisch, R; Liu, X; Wu, H	1
Macilwain, C	4
Marshall, E	1
Birnbaumer, L; Brabet, P; Bradley, A; Hasty, P; Rudolph, U	1
Blasberg, RG; Desai, R; Gansbacher, B; Stockhammer, G; Tjuvajev, JG; Uehara, H; Watanabe, K	1
Bari, A	1
Josephson, L	1
Lewis, W; Perrino, FW	1
Prince, AM	1
Gordon, M	1
Colacino, JM; Griniuviene, B; Levine, ES; Lewis, W; Perrino, FW; Sommadossi, JP; Tankersley, KO; Watanabe, KA	1
Bishop, JO; Ellison, AR	1
Eriksson, S; Wang, J	1
Colacino, JM	1
Beattie, B; Blasberg, RG; Finn, R; Joshi, R; Kennedy, J; Koutcher, J; Larson, S; Oku, T; Tjuvajev, JG; Watanabe, K	1
Meinert, CL	1
Ahluwalia, GS; Driscoll, JS; Ford, H; Johns, DG	1
Baxter, AJ; Colacino, JM; Huffman, DM; Mabry, TE; Richardson, FC; Richardson, KK; Scheuring, JC; Smith, WC; Staschke, KA	1
Ascenzi, MA; de Courten-Myers, G; Engelman, L; Gerin, JL; Griniuviene, B; Hornbuckle, WE; Levine, ES; Lewis, W; Montione, R; Tankersley, KO; Tennant, BC	1
Gaffey, MJ; Hoofnagle, JH; Kleiner, DE; McKenzie, R; Nichols, L; Sallie, R; Straus, SE; Tsokos, M	1
Colacino, JM; Horn, DM; Neeb, LA; Richardson, FC	1
Dalakas, MC; Leon-Monzon, M; Semino-Mora, C	1
Schmid, R	1
de Man, RA; Honkoop, P; Schalm, SW; Scholte, HR	1
Ascenzi, MA; Baldwin, BH; Bowsher, RR; Colacino, JM; Cote, PJ; Engelhardt, JA; Erb, HN; Gerin, JL; Graham, LA; Hornbuckle, WE; Korba, BE; Lewis, W; Lopez, C; Richardson, FC; Rowland, PH; Tennant, BC; Tochkov, IA; Yeager, AE	1
Vaidyanathan, G; Zalutsky, MR	1
Augensen, F; Avril, N; Beattie, B; Blasberg, R; Daghighian, F; DiResta, G; Finn, R; Humm, J; Joshi, R; Koutcher, J; Larson, SM; Miyagawa, T; Oku, T; Safer, M; Sasajima, T; Tjuvajev, JG; Zweit, J	1
Morton, DM	1
Miller, JP; Mintz, PD	1
Hasty, P; Klein, WH; Vivian, JL	1
Blasberg, RG; Tjuvajev, JG	1
Balatoni, J; Ballon, D; Blasberg, RG; Chen, SH; Finn, R; Guo, ZS; Joshi, A; Joshi, R; Koutcher, J; Tjuvajev, JG; Woo, SL	1
Chiu, JW; Jasin, M; Koller, BH; Moynahan, ME	1
Avril, N; Gansbacher, B; Hantzopoulos, PA; Haubner, R; Schwaiger, M	1
Breakefield, XO; Dubrovin, M; Hewett, J; Jacobs, A; Sadelain, M; Sena-Esteves, M; Slack, M; Tan, CW; Tjuvajev, JG	1
Anton, M; Avril, N; Bengel, FM; Brill, T; Gansbacher, B; Gleiter, E; Haubner, R; Nguyen, N; Schwaiger, M	1
Borrelli, E; Hindelang, C; LeMeur, M; Mathis, C	1
Buchsbaum, DJ; Chaudhuri, TR; Mountz, JM; Rogers, BE; Zinn, KR	1
Akhurst, T; Balatoni, J; Beattie, B; Blasberg, RG; Breakefield, XO; Chiocca, EA; Dubrovin, M; Finn, R; Herrlinger, U; Jacobs, A; Joshi, R; Larson, SM; Pechan, PA; Tjuvajev, JG	1
Fried, MW; Sommadossi, JP	1
Brandau, W; Bräunlich, I; Graf, R; Heiss, WD; Hesselmann, V; Jacobs, A; Lercher, M; Sakaki, T; Voges, J; Wienhard, K	1
Akhurst, T; Balatoni, J; Bennett, JJ; Blasberg, R; Doubrovin, M; Federoff, H; Finn, R; Fong, Y; Hackman, T; Johnson, P; Larson, SM; Malholtra, S; Tjuvajev, J	1
Anton, M; Avril, N; Brust, P; Friedrich, A; Haberkorn, U; Haubner, R; Hauses, M; Johannsen, B; Koufaki, ON; Noll, B; Noll, S; Schackert, G; Schackert, HK; Scheunemann, M	1
Bermudes, D; Blasberg, R; King, I; Luo, X; Tjuvajev, J; Zheng, LM	1
Gossmann, A; Heiss, WD; Jacobs, A; Kaestle, C; Kracht, L; Lercher, M; Reszka, R; Voges, J; Wagner, R; Wienhard, K	1
Akhurst, T; Alauddin, MM; Balatoni, J; Blasberg, RG; Bornmann, W; Cai, S; Conti, PS; Doubrovin, M; Finn, R; Thaler, H; Tjuvajev, JG	1
Avezaat, C; Bakker, W; Bijster, M; Cox, P; de Jong, M; Driesse, M; Havenga, M; Knaus, E; Morin, K; Naimi, E; Nanda, D; Smitt, PS; Vogels, R; Wiebe, L	1
Balatoni, J; Blasberg, RG; Bornmann, W; Doubrovin, M; Doubrovina, E; Finn, R; Gallardo, HF; Heller, G; Ivanova, A; Koehne, G; Larson, SM; May, C; O'Reilly, RJ; Ponomarev, V; Riviere, I; Ruan, S; Sadelain, M; Teruya-Feldstein, J; Tjuvajev, JG; Zanzonico, P	1
Akhurst, T; Balatoni, J; Banerjee, D; Bertino, JR; Blasberg, R; Doubrovin, M; Finn, R; Fong, Y; Gade, T; Gusani, NJ; Koutcher, JA; Larson, S; Mayer-Kuckuk, P; Tjuvajev, JG	1
Anderson, L; Klecker, RW; Mangner, TJ; Shields, AF	1
Borrelli, E; Collin, L; Mathis, C	1
Deng, WP; Fu, YK; Hwang, JJ; Lai, WF; Liu, RS; Wang, HE; Yang, DM; Yang, WK	1
Anton, M; Bengel, FM; Boekstegers, P; Brandau, W; Erhardt, W; Gansbacher, B; Haubner, R; Henke, J; Lehner, T; Nekolla, SG; Reder, S; Richter, T; Schwaiger, M; Simoes, MV	1
Gambhir, SS; Iyer, M; Min, JJ	1
Lai, Y; Tse, CM; Unadkat, JD	1
Ageyeva, L; Balatoni, J; Beresten, T; Blasberg, R; Bornmann, W; Doubrovin, M; Gelovani Tjuvajev, J; Ivanova, A; Ponomarev, V; Serganova, I; Shavrin, A; Tourkova, V; Vider, J	1
Blasberg, R; Burgman, P; Cai, S; Finn, R; Gelovani, J; Li, GC; Ling, CC; O'donoghue, J; Serganova, I; Wen, B; Zanzonico, P	1
Anton, M; Bengel, FM; Erhardt, W; Gambhir, SS; Gansbacher, B; Grote, M; Haubner, R; Lehner, T; Miyagawa, M; Noll, B; Noll, S; Reder, S; Schwaiger, M; Simoes, MV; Städele, C; Wagner, B	1
Anton, M; Bengel, FM; Epple, P; Haubner, R; Lehner, T; Linke, W; Miyagawa, M; Reder, S; Schwaiger, M; Simões, MV; Städele, C	1
Agrawal, N; Bettegowda, C; Cheong, I; Dang, LH; Diaz, L; Dick, J; Foss, CA; Fox, J; Kinzler, KW; Pomper, MG; Vogelstein, B; Wang, Y; Zhou, S	1
Lai, Y; Lee, EW; Unadkat, JD; Zhang, H	1
Blasberg, RG; Doubrovin, M; Doubrovina, E; Finn, R; Gallardo, HF; Koehne, G; Larson, SM; O'Reilly, RJ; Riviere, I; Sadelain, M; Zanzonico, P	1
Deng, WP; Gelovani, JG; Hwang, JJ; Lin, M; Liu, RS; Wang, HE; Wei, HJ; Yu, HM	1
Brown, SM; Dempsey, MF; Hadley, DM; Nicol, A; Owens, J; Papanastassiou, V; Patterson, J; Pimlott, S; Rampling, R; Wyper, D	1
Chen, FD; Chen, JC; Deng, WP; Hsieh, CH; Hwang, JJ; Liu, RS; Wang, HE	1
Ambinder, RF; Chen, J; Chong, JM; Foss, CA; Fox, JJ; Fu, DX; Lemas, V; Pomper, MG; Tanhehco, YC	1
Douglas, KA; Mangner, TJ; Muzik, O; Nimmagadda, S; Shields, AF	1
Agrawal, N; Bettegowda, C; Cheong, I; Conway, J; Diaz, LA; Endres, CJ; Foss, CA; Kinzler, KW; Ladenson, PW; Mont, MA; Nimmagadda, S; Pomper, MG; Seyler, TM; Thornton, K; Ulrich, SD; Uzuner, O; Vogelstein, B; Vogelstein, BN; Zhang, X; Zhou, S	1
Dhanvantari, S; Kovacs, MS; McGirr, R; Morgan, TG; Nguyen, B; Prato, FS; Tai, JH; Wells, RG	1
Dittmar, K; Heiss, WD; Jacob, AJ; Jacobs, AH; Knaus, EE; Li, HF; Moharram, S; Stöckle, M; Wiebe, LI; Winkeler, A	1
Deisenhofer, S; Glatting, G; Kull, T; Morgenroth, A; Neininger, M; Reske, SN; Vogg, AT	1
Chang, WS; Chen, CT; Hsu, CH; Lee, TW; Lin, KM	1
Endres, CJ; Govindarajan, R; LeCluyse, E; Pastor-Anglada, M; Tse, CM; Unadkat, JD; Whittington, D	1
Ambinder, RF; Chen, J; Chong, JM; Foss, CA; Fox, JJ; Fu, DX; Fukayama, M; Hobbs, RF; Kowalski, J; Pomper, MG; Sgouros, G; Tanhehco, Y	1
Chen, Q; Deng, X; He, F; Huang, Y; Li, GC; Ling, CC; Liu, Y; Minami, A; Sun, X; Wen, B; Xing, L; Zanzonico, PB	1
Blankemeyer, E; Chacko, AM; Kung, HF; Lieberman, BP; Qu, W	1
Lan, X; Liu, Y; Wang, R; Yin, X; Zhang, Y	1
Haberkorn, U; Lawhorn-Crews, JM; Mangner, TJ; Nimmagadda, S; Shields, AF	1
Be, NA; Bishai, WR; Davis, SL; Jain, SK; Lamichhane, G; Nimmagadda, S; Pomper, MG	1
Pomper, MG	1
Ahn, BC; Choi, TH; Ha, JH; Kim, IS; Lee, J; Lee, SW; Lee, YJ; Lee, YL; Park, SY	1
An, GI; Cheon, GJ; Choi, CW; Choi, TH; El-Gamal, MI; Hong, SH; Kim, EJ; Kim, KM; Lee, EA; Lee, KC; Lim, SM	1
Anderson, H; Cantorias, M; Lewis, JS; Pillarsetty, N	1
Awasthi, S; Awasthi, V; King, C; Lagisetty, P; Shankar, N; Vilekar, P	1
Cai, H; Conti, PS; Li, Z	1
Alauddin, M; Chan, PC; Chang, WT; Chang, WY; Chen, CL; Chen, FD; Lin, WJ; Liu, RS; Wang, HE; Wu, CY	1
An, GI; Cheon, GJ; Jang, SJ; Kang, JH; Kim, KI; Lee, KC; Lee, TS; Lee, YJ; Lim, S; Lim, SM	1
Cheng, Z; He, Y; Lan, X; Mghanga, FP; Pei, Z; Qin, C; Tian, Y; Wang, P; Yen, TC; Zhang, Y	1
Chun, KS; Kang, JH; Kim, KI; Lee, TS; Lee, YJ; Park, JJ; Park, YS; Son, JJ; Song, IH	1
An, R; Lang, J; Liu, Y; Sun, X; Wu, T; Zhang, B	1
Freeman, AF; Gharib, AM; Hammoud, DA; Holland, SM; Peterson, KL; Pettigrew, RI; Reid, WC	1
Heo, K; Kang, SH; Kim, D; Kim, EO; Kim, H; Kim, IH; Kim, KT; Kim, SK; Kim, YH; Koh, SS; Lee, SJ; Lee, SW; Lee, Y; Moon, JY; Song, MS	1
Glenn, J; Guo, YY; Masek, M; Michie, SA; Nishimura, S; Nishimura, T; Peltz, G; Xu, D; Zhang, H; Zheng, M	1
Cohen, J	1
Bettegowda, C; Cheung, PH; DeCrescenzo, G; Saha, S; Tung, D; Welsch, D	1
Bell, CC; Dankers, AC; Ellis, E; Fredriksson Puigvert, L; Goldring, CE; Hendriks, DF; Ingelman-Sundberg, M; Jacobs, F; Jenkins, RE; Kitteringham, NR; Lauschke, VM; Mkrtchian, S; Moro, SM; Nordling, Å; Park, BK; Renblom, A; Sison-Young, RL; Snoeys, J; Walsh, J	1
Alavi, A; Barnett, TM; Berkowitz, RD; Bettegowda, C; Cho, SY; Conklin, JJ; Gelb, J; McLeroth, P; Mont, MA; Petit, C; Pomper, MG; Saha, S; Siegel, BA; Spaltro, J; Stabin, MG; Zhang, HH; Zhang, XM	1
Amberntsson, S; Andersson, LC; Cairns, J; Chouhan, B; Darnell, M; Ewart, L; Foster, AJ; Hamilton, GA; Jang, KJ; Kodella, K; Lazic, SE; Morgan, P; Petropolis, DB; Regan, SL; Rollison, H; Rubins, JE; Srivastava, A; Williams, D	1
Beckett, AJ; Chadwick, AE; Douglas, O; Jenkins, RE; Jolly, CE; Kamalian, L; Monshouwer, M; Park, BK; Penman, SL; Simic, D; Snoeys, J; Williams, DP	1
Dixon, D; Fallon, JK; Liu, J; Mosedale, M; Nautiyal, M; Qasem, RJ; Smith, PC; Wolf, KK	1

Reviews

8 review(s) available for arabinofuranosyluracil and fialuridine

Article	Year
Fluorinated pyrimidines: a new change for old drugs. Transplantation proceedings, 1991, Volume: 23, Issue:3 Suppl 3 Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Arabinofuranosyluracil; Bone Marrow Transplantation; Cytarabine; Cytomegalovirus; Cytomegalovirus Infections; Pyrimidines; Structure-Activity Relationship	1991
Mitochondrial toxicity of antiviral drugs. Nature medicine, 1995, Volume: 1, Issue:5 Topics: Acquired Immunodeficiency Syndrome; Animals; Antiviral Agents; Arabinofuranosyluracil; Didanosine; DNA-Directed DNA Polymerase; DNA, Mitochondrial; Humans; Mitochondria; Zalcitabine; Zidovudine	1995
New nucleoside analogues for chronic hepatitis B. Journal of hepatology, 1995, Volume: 22, Issue:1 Suppl Topics: 2-Aminopurine; Antiviral Agents; Arabinofuranosyluracil; Chronic Disease; Drug Evaluation, Preclinical; Famciclovir; Hepatitis B; Humans; Lamivudine; Nucleosides; Zalcitabine	1995
New developments in antiviral therapy for chronic hepatitis B infection. Scandinavian journal of gastroenterology. Supplement, 1995, Volume: 212 Topics: 2-Aminopurine; Antiviral Agents; Arabinofuranosyluracil; Clinical Trials as Topic; Famciclovir; Hepatitis B; Hepatitis, Chronic; Humans; Interferon-alpha; Lamivudine; Treatment Outcome; Zalcitabine	1995
Mechanisms for the anti-hepatitis B virus activity and mitochondrial toxicity of fialuridine (FIAU). Antiviral research, 1996, Volume: 29, Issue:2-3 Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; DNA, Mitochondrial; Electron Transport Complex IV; Hepatitis B; Hepatitis B virus; Humans; Liver	1996
Mitochondrial injury. Lessons from the fialuridine trial. Drug safety, 1997, Volume: 17, Issue:1 Topics: Antiviral Agents; Arabinofuranosyluracil; Clinical Trials as Topic; Clinical Trials, Phase II as Topic; DNA-Directed DNA Polymerase; Hepatitis B; Hepatitis B virus; Humans; Liver; Mitochondria; Oxidation-Reduction; Pyruvates; Risk Assessment; Structure-Activity Relationship	1997
Herpes simplex virus thymidine kinase as a marker/reporter gene for PET imaging of gene therapy. The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), 1999, Volume: 43, Issue:2 Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Gene Expression Regulation, Enzymologic; Genes, Reporter; Genetic Markers; Genetic Therapy; Neoplasms, Experimental; Radiopharmaceuticals; Simplexvirus; Thymidine Kinase; Tomography, Emission-Computed; Transgenes; Tumor Cells, Cultured	1999
Nucleoside analogues and other investigational modalities for the treatment of chronic hepatitis B. Antiviral therapy, 1996, Volume: 1, Issue:2 Topics: 2-Aminopurine; Animals; Antiviral Agents; Arabinofuranosyluracil; Clinical Trials as Topic; Combined Modality Therapy; Dideoxynucleosides; Famciclovir; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Transplantation; Reverse Transcriptase Inhibitors; Ribavirin; Vidarabine	1996

Trials

5 trial(s) available for arabinofuranosyluracil and fialuridine

Article	Year
Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B. The New England journal of medicine, 1995, Oct-26, Volume: 333, Issue:17 Topics: Acidosis, Lactic; Adult; Alanine Transaminase; Antiviral Agents; Arabinofuranosyluracil; Chronic Disease; DNA, Mitochondrial; DNA, Viral; Drugs, Investigational; Female; Hepatitis B; Humans; Jaundice; Liver; Liver Failure; Liver Transplantation; Male; Middle Aged; Pancreatitis; Peripheral Nervous System Diseases	1995
Deaths in US fialuridine trial. Lancet (London, England), 1994, Jun-11, Volume: 343, Issue:8911 Topics: Acidosis, Lactic; Acquired Immunodeficiency Syndrome; Animals; Antiviral Agents; Arabinofuranosyluracil; Cause of Death; Chronic Disease; Female; Hepatitis B; Humans; Male; Middle Aged; Survival Rate	1994
Positron-emission tomography of vector-mediated gene expression in gene therapy for gliomas. Lancet (London, England), 2001, Sep-01, Volume: 358, Issue:9283 Topics: Aged; Antiviral Agents; Arabinofuranosyluracil; Gene Expression Regulation, Viral; Genetic Therapy; Glioblastoma; Herpesvirus 1, Human; Humans; Middle Aged; Neoplasm Recurrence, Local; Predictive Value of Tests; Thymidine Kinase; Tomography, Emission-Computed; Transduction, Genetic	2001
Assessment of 123I-FIAU imaging of herpes simplex viral gene expression in the treatment of glioma. Nuclear medicine communications, 2006, Volume: 27, Issue:8 Topics: Arabinofuranosyluracil; Gene Expression; Gene Expression Profiling; Genetic Therapy; Glioma; Humans; Iodine Radioisotopes; Radionuclide Imaging; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Simplexvirus; Thymidine Kinase; Viral Proteins; Virus Replication	2006
[(124)I]FIAU: Human dosimetry and infection imaging in patients with suspected prosthetic joint infection. Nuclear medicine and biology, 2016, Volume: 43, Issue:5 Topics: Adult; Arabinofuranosyluracil; Female; Humans; Joint Diseases; Male; Positron Emission Tomography Computed Tomography; Prosthesis-Related Infections; Radiometry; Safety; Tissue Distribution	2016

Other Studies

126 other study(ies) available for arabinofuranosyluracil and fialuridine

Article	Year
Antiviral activity of FIAU (1-[2'deoxy-2'-fluoro-1-beta-D-arabinofuranosyl]-5-iodo-uridine) on strains of cytomegalovirus sensitive and resistant to ganciclovir. The Journal of infectious diseases, 1991, Volume: 163, Issue:6 Topics: Antiviral Agents; Arabinofuranosyluracil; Cytomegalovirus; Drug Resistance, Microbial; Ganciclovir; Humans	1991
Equine herpes virus 1 and pseudorabies virus resistance to 2'-fluoropyrimidine analogs and to bromovinyldeoxyuridine: implications for dTMP kinase activity. Acta virologica, 1990, Volume: 34, Issue:6 Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Bromodeoxyuridine; Cytarabine; Drug Resistance, Microbial; Herpesviridae; Herpesvirus 1, Suid; Horses; Nucleoside-Phosphate Kinase; Pseudorabies; Pyrimidine Nucleosides; Substrate Specificity	1990
Transgenic mice with inducible dwarfism. Nature, 1989, Jun-15, Volume: 339, Issue:6225 Topics: Animals; Arabinofuranosyluracil; Body Weight; Dwarfism, Pituitary; Growth Hormone; Immunohistochemistry; Mice; Mice, Transgenic; Pituitary Gland; Prolactin; Thymidine Kinase	1989
Targeting of an inducible toxic phenotype in animal cells. Proceedings of the National Academy of Sciences of the United States of America, 1988, Volume: 85, Issue:20 Topics: Acyclovir; Animals; Antiviral Agents; Arabinofuranosyluracil; Blotting, Northern; Blotting, Southern; Cell Line; Cell Line, Transformed; Cell Survival; Densitometry; DNA Replication; Gene Expression Regulation; Mice; Mice, Transgenic; Plasmids; Rats; Simplexvirus; Spleen; Thymidine Kinase; Thymus Gland; Transfection; Uridine	1988
Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus. Journal of virology, 1985, Volume: 53, Issue:2 Topics: Acyclovir; Antiviral Agents; Arabinofuranosyluracil; Arabinonucleosides; Bromodeoxyuridine; DNA-Directed DNA Polymerase; Drug Resistance, Microbial; Foscarnet; Ganciclovir; Genes, Viral; Idoxuridine; Mutation; Phosphonoacetic Acid; Simplexvirus; Thymidine; Vidarabine	1985
Comparative efficacy of three 2'-fluoropyrimidine nucleosides and 9-(1,3-dihydroxy-2-propoxymethyl)guanine (BW B759U) against pseudorabies and equine rhinopneumonitis virus infection in vitro and in laboratory animals. Antiviral research, 1987, Volume: 7, Issue:1 Topics: Acyclovir; Animals; Antiviral Agents; Arabinofuranosyluracil; Cricetinae; Cytarabine; Ganciclovir; Herpesviridae Infections; Herpesvirus 1, Equid; Herpesvirus 1, Suid; Male; Mice; Pseudorabies; Pyrimidine Nucleosides	1987
A mammalian cell line designed to test the mutagenic activity of anti-herpes nucleosides. International journal of cancer, 1987, Jul-15, Volume: 40, Issue:1 Topics: Acyclovir; Animals; Antiviral Agents; Arabinofuranosyluracil; Cell Division; Cell Line; Cricetinae; Cricetulus; Cytarabine; DNA, Viral; Idoxuridine; Mutagenicity Tests; Nucleosides; Simplexvirus; Thymidine Kinase; Transfection; Trifluridine	1987
Effect of acyclovir on the uptake of 131I-labelled 1-(2'fluoro-2'-deoxy-beta-D-arabinofuranosyl)-5-iodouracil in herpes infected cells. Journal of medical virology, 1987, Volume: 22, Issue:2 Topics: Acyclovir; Animals; Arabinofuranosyluracil; Cells, Cultured; Simplexvirus; Time Factors; Uridine	1987
[Radiosensitization effects of nucleoside analogs]. Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica, 1986, Dec-25, Volume: 46, Issue:12 Topics: Acyclovir; Animals; Antineoplastic Agents; Arabinofuranosyluracil; Cytarabine; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Nucleosides; Radiation-Sensitizing Agents; Vidarabine; Whole-Body Irradiation	1986
Selective inhibitory effects of (S)-9-(3-hydroxy-2-phosphonyl-methoxypropyl) adenine and 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodouracil on seal herpesvirus (phocid herpesvirus 1) infection in vitro. Antiviral research, 1987, Volume: 7, Issue:4 Topics: Adenine; Animals; Antiviral Agents; Arabinofuranosyluracil; Cells, Cultured; Herpesviridae; Organophosphonates; Organophosphorus Compounds; Seals, Earless; Uridine	1987
Activity of 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodouracil against simian varicella virus infections in African green monkeys. Antimicrobial agents and chemotherapy, 1986, Volume: 29, Issue:1 Topics: Administration, Oral; Animals; Antiviral Agents; Arabinofuranosyluracil; Aspartate Aminotransferases; Chickenpox; Chlorocebus aethiops; Female; Injections, Intravenous; Male; Time Factors; Uridine	1986
Quantitative determination of antiviral nucleoside analog in DNA. Analytical biochemistry, 1986, Aug-01, Volume: 156, Issue:2 Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Cells, Cultured; Chlorocebus aethiops; Chromatography, High Pressure Liquid; Cytarabine; DNA, Viral; Herpesviridae; Hydrolysis; Nucleosides	1986
Kinetics and substrate specificity of human and canine cytidine deaminase. Biochemical pharmacology, 1986, Apr-01, Volume: 35, Issue:7 Topics: Animals; Arabinofuranosyluracil; Cytarabine; Cytidine; Cytidine Deaminase; Deoxycytidine; Dogs; Humans; Kinetics; Liver; Nucleoside Deaminases; Substrate Specificity	1986
Effect of eight antiviral drugs on the reactivation of herpes simplex virus in explant cultures of latently infected mouse trigeminal ganglia. The Journal of investigative dermatology, 1984, Volume: 83, Issue:5 Topics: Acyclovir; Animals; Antibodies, Viral; Antiviral Agents; Arabinofuranosyluracil; Arabinonucleosides; Bromodeoxyuridine; Culture Media; Culture Techniques; Cytarabine; Foscarnet; Mice; Mice, Hairless; Neutralization Tests; Phosphonoacetic Acid; Simplexvirus; Thymidine; Trigeminal Nerve; Vidarabine Phosphate; Virus Activation	1984
Treatment of primary acute genital herpes in guinea pigs by intraperitoneal administration of fluoropyrimidines. Antimicrobial agents and chemotherapy, 1984, Volume: 26, Issue:3 Topics: Acyclovir; Animals; Antiviral Agents; Arabinofuranosyluracil; Cytarabine; Female; Foscarnet; Guinea Pigs; Herpes Genitalis; Injections, Intraperitoneal; Male; Phosphonoacetic Acid; Uridine; Virus Replication	1984
Priming of duck hepatitis B virus reverse transcription in vitro: premature termination of primer DNA induced by the 5'-triphosphate of fialuridine. Journal of virology, 1994, Volume: 68, Issue:12 Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; DNA Replication; DNA, Viral; Hepatitis B Virus, Duck; Kinetics; Mutagenesis, Site-Directed; Plasmids; Protein Biosynthesis; Rabbits; Reticulocytes; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; RNA, Viral; Substrate Specificity; Templates, Genetic; Transcription, Genetic	1994
Mitochondrial toxicity--new adverse drug effects. The New England journal of medicine, 1995, Oct-26, Volume: 333, Issue:17 Topics: Antiviral Agents; Arabinofuranosyluracil; Chronic Disease; Clinical Trials as Topic; DNA, Mitochondrial; Hepatitis B; Humans; Liver Failure	1995
IOM panel exonerates researchers in FIAU deaths. JAMA, 1995, Apr-19, Volume: 273, Issue:15 Topics: Antiviral Agents; Arabinofuranosyluracil; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Drugs, Investigational; Humans; Liver Diseases; Malpractice; National Academies of Science, Engineering, and Medicine, U.S., Health and Medicine Division; United States	1995
Toxicity, metabolism, DNA incorporation with lack of repair, and lactate production for 1-(2'-fluoro-2'-deoxy-beta-D-arabinofuranosyl)-5-iodouracil in U-937 and MOLT-4 cells. Molecular pharmacology, 1994, Volume: 46, Issue:6 Topics: Arabinofuranosyluracil; DNA; DNA Repair; Humans; Lactates; Liver; Molecular Structure; Tumor Cells, Cultured	1994
Effect of fialuridine on replication of mitochondrial DNA in CEM cells and in human hepatoblastoma cells in culture. Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:9 Topics: Antiviral Agents; Arabinofuranosyluracil; Cells, Cultured; DNA Replication; DNA, Mitochondrial; Hepatoblastoma; Humans; Lactates; Lactic Acid; Liver Neoplasms; T-Lymphocytes; Tumor Cells, Cultured; Zalcitabine	1994
Sensitive and specific radioimmunoassay for fialuridine: initial assessment of pharmacokinetics after single oral doses to healthy volunteers. Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:9 Topics: Administration, Oral; Adult; Animals; Antiviral Agents; Arabinofuranosyluracil; Binding, Competitive; Biological Availability; Drug Administration Schedule; Fasting; Female; Humans; Iodine Radioisotopes; Male; Middle Aged; Rabbits; Radioimmunoassay; Reproducibility of Results; Sensitivity and Specificity	1994
Cellular and molecular events leading to mitochondrial toxicity of 1-(2-deoxy-2-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil in human liver cells. The Journal of clinical investigation, 1995, Volume: 95, Issue:2 Topics: Adenosine Triphosphate; Antiviral Agents; Arabinofuranosyluracil; Carcinoma, Hepatocellular; Cell Division; Cell Nucleus; Chromatography, High Pressure Liquid; DNA, Mitochondrial; DNA, Neoplasm; Humans; Kinetics; Liver Neoplasms; Microscopy, Electron; Mitochondria; Mitochondria, Liver; Time Factors; Tumor Cells, Cultured	1995
Effects of fialuridine on hepatitis B immune globulin pharmacokinetics following orthotopic liver transplant for chronic hepatitis B viral-induced cirrhosis. Transplantation proceedings, 1995, Volume: 27, Issue:1 Topics: Adult; Antiviral Agents; Arabinofuranosyluracil; DNA, Viral; Female; Hepatitis B; Hepatitis B Core Antigens; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Immunoglobulins, Intravenous; Liver Cirrhosis; Liver Transplantation; Male	1995
Clinical course of four patients receiving the experimental antiviral agent fialuridine for the treatment of chronic hepatitis B infection. Transplantation proceedings, 1995, Volume: 27, Issue:1 Topics: Antiviral Agents; Arabinofuranosyluracil; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Hepatitis B; Humans; Lactates; Liver Transplantation; Randomized Controlled Trials as Topic	1995
Panel clears NIH in patient deaths. Science (New York, N.Y.), 1995, Mar-24, Volume: 267, Issue:5205 Topics: Antiviral Agents; Arabinofuranosyluracil; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Humans; National Academies of Science, Engineering, and Medicine, U.S., Health and Medicine Division; National Institutes of Health (U.S.); United States; United States Food and Drug Administration	1995
The context of consent. Lancet (London, England), 1994, Jul-23, Volume: 344, Issue:8917 Topics: Antiviral Agents; Arabinofuranosyluracil; Clinical Trials as Topic; Comprehension; Consent Forms; Disclosure; Ethics, Medical; Humans; Informed Consent; Research Subjects; Researcher-Subject Relations; Risk Assessment; Tamoxifen; United States	1994
Mammalian DNA polymerases alpha, beta, gamma, delta, and epsilon incorporate fialuridine (FIAU) monophosphate into DNA and are inhibited competitively by FIAU Triphosphate. Biochemistry, 1994, Dec-06, Volume: 33, Issue:48 Topics: Animals; Arabinofuranosyluracil; Binding, Competitive; Deoxyuracil Nucleotides; DNA; DNA-Directed DNA Polymerase; Kinetics; Mammals; Mitochondria; Nucleic Acid Synthesis Inhibitors; Substrate Specificity; Templates, Genetic; Thymine Nucleotides	1994
Fialuridine accumulates in DNA of dogs, monkeys, and rats following long-term oral administration. Proceedings of the National Academy of Sciences of the United States of America, 1994, Dec-06, Volume: 91, Issue:25 Topics: Administration, Oral; Animals; Antiviral Agents; Arabinofuranosyluracil; Chromatography, High Pressure Liquid; DNA; Dogs; Female; Hydrolysis; Macaca mulatta; Male; Muscles; Radioimmunoassay; Rats; Rats, Inbred F344; Sex Factors; Species Specificity; Time Factors; Tissue Distribution	1994
NIH panel report of 'no flaws' in FIAU trial at variance with FDA report, new probe planned. JAMA, 1994, Jul-06, Volume: 272, Issue:1 Topics: Antiviral Agents; Arabinofuranosyluracil; Cause of Death; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Hepatitis B; Hepatitis, Chronic; Humans; Liver Diseases; National Institutes of Health (U.S.); Scientific Misconduct; United States; United States Food and Drug Administration	1994
The in vitro anti-hepatitis B virus activity of FIAU [1-(2'-deoxy-2'-fluoro-1-beta-D-arabinofuranosyl-5-iodo)uracil] is selective, reversible, and determined, at least in part, by the host cell. Antiviral research, 1994, Volume: 23, Issue:1 Topics: Antiviral Agents; Arabinofuranosyluracil; Base Sequence; Hepatitis B virus; Hepatitis B Virus, Duck; Hepatoblastoma; Humans; Molecular Sequence Data; Thymidine; Tumor Cells, Cultured; Virus Replication	1994
Double replacement: strategy for efficient introduction of subtle mutations into the murine Col1a-1 gene by homologous recombination in embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America, 1994, Mar-29, Volume: 91, Issue:7 Topics: Animals; Arabinofuranosyluracil; Cells, Cultured; Collagen; Collagenases; Embryo, Mammalian; Genetic Vectors; Mice; Mutagenesis; Point Mutation; Recombination, Genetic; Selection, Genetic; Stem Cells	1994
Concern grows over reaction to deaths in clinical trials. Nature, 1994, May-26, Volume: 369, Issue:6478 Topics: Antiviral Agents; Arabinofuranosyluracil; Clinical Trials as Topic; Humans; National Institutes of Health (U.S.); United States; United States Food and Drug Administration	1994
US health agencies at odds over trial deaths. Nature, 1994, Jun-09, Volume: 369, Issue:6480 Topics: Arabinofuranosyluracil; Clinical Trials as Topic; Humans; Liver Failure; National Institutes of Health (U.S.); Research Design; United States; United States Food and Drug Administration	1994
Hepatitis study. Drug trial deaths deemed unavoidable. Science (New York, N.Y.), 1994, Jun-10, Volume: 264, Issue:5165 Topics: Antiviral Agents; Arabinofuranosyluracil; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Federal Government; Government Regulation; Hepatitis B; Humans; National Institutes of Health (U.S.); Pancreatic Diseases; Research Subjects; United States; United States Food and Drug Administration	1994
Trial deaths prompt tighter rules. Nature, 1993, Nov-25, Volume: 366, Issue:6453 Topics: Antiviral Agents; Arabinofuranosyluracil; Clinical Trials as Topic; Humans; United States; United States Food and Drug Administration	1993
Disruption of the G(i2) alpha locus in embryonic stem cells and mice: a modified hit and run strategy with detection by a PCR dependent on gap repair. Transgenic research, 1993, Volume: 2, Issue:6 Topics: Animals; Arabinofuranosyluracil; Base Sequence; Chimera; Culture Techniques; DNA Primers; Embryo, Mammalian; Genetic Vectors; GTP-Binding Proteins; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Polymerase Chain Reaction; Recombination, Genetic; Stem Cells; Thymidine Kinase	1993
NIH, FDA seek lessons from hepatitis B drug trial deaths. Nature, 1993, Jul-22, Volume: 364, Issue:6435 Topics: Antiviral Agents; Arabinofuranosyluracil; Hepatitis B; Humans; National Institutes of Health (U.S.); United States; United States Food and Drug Administration	1993
Imaging the expression of transfected genes in vivo. Cancer research, 1995, Dec-15, Volume: 55, Issue:24 Topics: Animals; Arabinofuranosyluracil; Autoradiography; Ganciclovir; Gene Expression; Genetic Therapy; Idoxuridine; Rats; RNA, Messenger; Thymidine Kinase; Transfection; Tumor Cells, Cultured	1995
Severe toxicity of fialuridine (FIAU) The New England journal of medicine, 1996, Apr-25, Volume: 334, Issue:17 Topics: Antiviral Agents; Arabinofuranosyluracil; Chronic Disease; Hepatitis B; Humans; Interferons; Nucleosides	1996
Severe toxicity of fialuridine (FIAU) The New England journal of medicine, 1996, Apr-25, Volume: 334, Issue:17 Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Drug Evaluation, Preclinical; Hepatitis; Humans; Marmota	1996
Severe toxicity of fialuridine (FIAU) The New England journal of medicine, 1996, Apr-25, Volume: 334, Issue:17 Topics: Antiviral Agents; Arabinofuranosyluracil; DNA Polymerase III; DNA, Mitochondrial; Drug Evaluation, Preclinical; Hepatitis B; Humans; In Vitro Techniques	1996
Severe toxicity of fialuridine (FIAU) The New England journal of medicine, 1996, Apr-25, Volume: 334, Issue:17 Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Chronic Disease; Disease Models, Animal; Drug Evaluation, Preclinical; Hepatitis; Humans; Marmota; Pan troglodytes	1996
Severe toxicity of fialuridine (FIAU) The New England journal of medicine, 1996, Apr-25, Volume: 334, Issue:17 Topics: Antiviral Agents; Arabinofuranosyluracil; Chronic Disease; Cytarabine; Drug Approval; Hepatitis B; Humans	1996
Fialuridine and its metabolites inhibit DNA polymerase gamma at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts. Proceedings of the National Academy of Sciences of the United States of America, 1996, Apr-16, Volume: 93, Issue:8 Topics: Antiviral Agents; Arabinofuranosyluracil; Base Sequence; Binding Sites; Cell Line; DNA Polymerase III; DNA Primers; DNA, Mitochondrial; Humans; Kinetics; Microscopy, Electron; Mitochondria, Liver; Molecular Sequence Data	1996
Initiation of herpes simplex virus thymidine kinase polypeptides. Nucleic acids research, 1996, Jun-01, Volume: 24, Issue:11 Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Base Sequence; Bromodeoxyuridine; Codon; Electrophoresis, Polyacrylamide Gel; Ganciclovir; Gene Expression; Herpesvirus 1, Human; Male; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; RNA, Messenger; Testis; Thymidine Kinase; Transfection	1996
Phosphorylation of the anti-hepatitis B nucleoside analog 1-(2'-deoxy-2'-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil (FIAU) by human cytosolic and mitochondrial thymidine kinase and implications for cytotoxicity. Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:6 Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Cattle; Cells, Cultured; Cytosol; Humans; Mitochondria; Phosphorylation; Substrate Specificity; Thymidine Kinase	1996
Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: a potential method for monitoring clinical gene therapy. Cancer research, 1996, Sep-15, Volume: 56, Issue:18 Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Carbon Radioisotopes; Cell Line; Gamma Cameras; Ganciclovir; Gene Transfer Techniques; Genetic Therapy; Glioma; Immunohistochemistry; Iodine Radioisotopes; Magnetic Resonance Imaging; Mammary Neoplasms, Experimental; Rats; Rats, Nude; Sensitivity and Specificity; Simplexvirus; Thymidine Kinase; Tomography, Emission-Computed, Single-Photon	1996
An open letter to the FDA regarding changes in reporting procedures for drugs and biologics proposed in the wake of the FIAU tragedy. Controlled clinical trials, 1996, Volume: 17, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Antiviral Agents; Arabinofuranosyluracil; Cidofovir; Cost-Benefit Analysis; Cytosine; Drug Evaluation; Forms and Records Control; Humans; Organophosphonates; Organophosphorus Compounds; Safety Management; United States; United States Food and Drug Administration	1996
Comparison of the DNA incorporation in human MOLT-4 cells of two 2'-beta-fluoronucleosides, 2'-beta-fluoro-2',3'-dideoxyadenosine and fialuridine. Journal of pharmaceutical sciences, 1996, Volume: 85, Issue:4 Topics: Antiviral Agents; Arabinofuranosyluracil; Cell Line; Dideoxyadenosine; DNA; Humans	1996
Differential effects of the incorporation of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodouracil (FIAU) on the binding of the transcription factors, AP-1 and TFIID, to their cognate target DNA sequences. Nucleic acids research, 1996, Nov-01, Volume: 24, Issue:21 Topics: Antiviral Agents; Arabinofuranosyluracil; Binding, Competitive; Deoxyribonuclease BamHI; Deoxyribonucleases, Type II Site-Specific; DNA; Electrophoresis, Polyacrylamide Gel; HeLa Cells; Humans; Protein Binding; Transcription Factor AP-1; Transcription Factor TFIID; Transcription Factors	1996
Depletion of mitochondrial DNA, destruction of mitochondria, and accumulation of lipid droplets result from fialuridine treatment in woodchucks (Marmota monax). Laboratory investigation; a journal of technical methods and pathology, 1997, Volume: 76, Issue:1 Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; DNA Damage; DNA, Mitochondrial; Heart; Hepatitis B; Hepatitis B Virus, Woodchuck; Kidney; Lipids; Liver; Marmota; Mitochondria; Mitochondria, Muscle; Muscle, Skeletal; Myocardium	1997
Histopathologic changes associated with fialuridine hepatotoxicity. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 1997, Volume: 10, Issue:3 Topics: Adult; Antiviral Agents; Arabinofuranosyluracil; Chemical and Drug Induced Liver Injury; Chronic Disease; Clinical Trials, Phase II as Topic; Female; Hepatitis B; Humans; Liver; Male; Middle Aged; Randomized Controlled Trials as Topic	1997
Fialuridine is phosphorylated and inhibits DNA synthesis in isolated rat hepatic mitochondria. Antiviral research, 1997, Volume: 34, Issue:1 Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; DNA Replication; Mitochondria, Liver; Phosphorylation; Rats	1997
Mitochondrial and cellular toxicity induced by fialuridine in human muscle in vitro. Laboratory investigation; a journal of technical methods and pathology, 1997, Volume: 76, Issue:4 Topics: Antibodies, Monoclonal; Antiviral Agents; Arabinofuranosyluracil; Cells, Cultured; Humans; Microscopy, Electron; Mitochondria, Muscle; Muscle Fibers, Skeletal; Muscle, Skeletal; Neural Cell Adhesion Molecules; Organelles	1997
Fialuridine toxicity. Hepatology (Baltimore, Md.), 1997, Volume: 25, Issue:6 Topics: Antiviral Agents; Arabinofuranosyluracil; Humans; Liver	1997
Antiviral activity and toxicity of fialuridine in the woodchuck model of hepatitis B virus infection. Hepatology (Baltimore, Md.), 1998, Volume: 28, Issue:1 Topics: Animals; Anorexia; Antiviral Agents; Arabinofuranosyluracil; Carrier State; DNA, Viral; Hepatitis B; Hepatitis B Core Antigens; Hepatitis B virus; Liver; Marmota; Muscles; Sleep Stages; Time Factors; Virus Replication	1998
Preparation of 5-[131I]iodo- and 5-[211At]astato-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) uracil by a halodestannylation reaction. Nuclear medicine and biology, 1998, Volume: 25, Issue:5 Topics: Animals; Arabinofuranosyluracil; Cell Line; DNA; Drug Stability; Humans; Indicators and Reagents; Iodine Radioisotopes; Isotope Labeling; Mice; Radiopharmaceuticals; Tin; Tissue Distribution; Tumor Cells, Cultured	1998
Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography. Cancer research, 1998, Oct-01, Volume: 58, Issue:19 Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Carcinoma 256, Walker; Female; Ganciclovir; Gene Transfer Techniques; Glioma; Herpesvirus 1, Human; Iodine Radioisotopes; Magnetic Resonance Imaging; Mammary Neoplasms, Experimental; Neoplasms, Experimental; Rats; Rats, Nude; Sensitivity and Specificity; Thymidine Kinase; Tomography, Emission-Computed	1998
Importance of species selection in drug toxicity testing. Toxicology letters, 1998, Dec-28, Volume: 102-103 Topics: Animals; Arabinofuranosyluracil; Humans; Pharmacokinetics; Species Specificity; Toxicology	1998
Falsely low calcium measurements after high volume plasma exchange in a patient with liver failure. Transfusion science, 1994, Volume: 15, Issue:3 Topics: Acidosis, Lactic; Anticoagulants; Antiviral Agents; Arabinofuranosyluracil; Calcium; Citrates; Citric Acid; Hepatitis B; Hepatorenal Syndrome; Humans; Liver Failure; Liver Transplantation; Male; Middle Aged; Plasma Exchange; Predictive Value of Tests; Spectrophotometry, Atomic	1994
Temporal, spatial and tissue-specific expression of a myogenin-lacZ transgene targeted to the Hprt locus in mice. BioTechniques, 1999, Volume: 27, Issue:1 Topics: Animals; Arabinofuranosyluracil; Gene Expression Regulation, Developmental; Gene Targeting; Herpesvirus 1, Human; Histocytochemistry; Hypoxanthine Phosphoribosyltransferase; Lac Operon; Mice; Mice, Transgenic; Muscle Proteins; Muscle, Skeletal; Myogenin; Promoter Regions, Genetic; Stem Cells; Thymidine Kinase; X Chromosome	1999
Imaging adenoviral-mediated herpes virus thymidine kinase gene transfer and expression in vivo. Cancer research, 1999, Oct-15, Volume: 59, Issue:20 Topics: Adenoviridae; Animals; Arabinofuranosyluracil; Autoradiography; Colonic Neoplasms; Ganciclovir; Gene Expression; Gene Transfer Techniques; Genetic Therapy; Iodine Radioisotopes; Magnetic Resonance Imaging; Mice; Mice, Inbred BALB C; Simplexvirus; Thymidine Kinase; Tumor Cells, Cultured	1999
Brca1 controls homology-directed DNA repair. Molecular cell, 1999, Volume: 4, Issue:4 Topics: Animals; Arabinofuranosyluracil; BRCA1 Protein; Cell Line; Chromosomes; DNA Damage; DNA Repair; DNA-Binding Proteins; Gene Targeting; Mice; Mice, Knockout; Mutation; Proto-Oncogene Proteins; Rad51 Recombinase; Recombination, Genetic; Retinoblastoma Protein; Stem Cells; Thymidine Kinase; Transfection	1999
In vivo imaging of herpes simplex virus type 1 thymidine kinase gene expression: early kinetics of radiolabelled FIAU. European journal of nuclear medicine, 2000, Volume: 27, Issue:3 Topics: Animals; Arabinofuranosyluracil; Chromatography, High Pressure Liquid; Fibrosarcoma; Gene Expression; Gene Transfer Techniques; Genes, Reporter; Genetic Therapy; Herpesvirus 1, Human; Iodine Radioisotopes; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Radionuclide Imaging; Thymidine Kinase; Tissue Distribution; Transduction, Genetic	2000
Functional coexpression of HSV-1 thymidine kinase and green fluorescent protein: implications for noninvasive imaging of transgene expression. Neoplasia (New York, N.Y.), 1999, Volume: 1, Issue:2 Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Blotting, Western; Cell Separation; Cloning, Molecular; DNA, Complementary; Dose-Response Relationship, Drug; Flow Cytometry; Ganciclovir; Genetic Therapy; Green Fluorescent Proteins; Herpesvirus 1, Human; Luminescent Proteins; Microscopy, Fluorescence; Promoter Regions, Genetic; Rats; Recombinant Fusion Proteins; Retroviridae; Thymidine Kinase; Transduction, Genetic; Transgenes; Tumor Cells, Cultured	1999
Uptake of radiolabeled 2'-fluoro-2'-deoxy-5-iodo-1-beta-D-arabinofuranosyluracil in cardiac cells after adenoviral transfer of the herpesvirus thymidine kinase gene: the cellular basis for cardiac gene imaging. Circulation, 2000, Aug-29, Volume: 102, Issue:9 Topics: Adenoviridae; Animals; Arabinofuranosyluracil; Autoradiography; Carbon Radioisotopes; Cell Line; Gene Expression; Gene Transfer Techniques; Genes, Reporter; Genetic Therapy; Genetic Vectors; Injections, Intravenous; Iodine Radioisotopes; Myocardium; Radiopharmaceuticals; Rats; Rats, Wistar; Simplexvirus; Thymidine Kinase; Time Factors	2000
A transgenic mouse model for inducible and reversible dysmyelination. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Oct-15, Volume: 20, Issue:20 Topics: Animals; Antigens, Differentiation; Arabinofuranosyluracil; Blotting, Northern; Brain; Demyelinating Diseases; Disease Models, Animal; Female; Glial Fibrillary Acidic Protein; Gliosis; Herpesvirus 1, Human; In Situ Hybridization; Male; Mice; Mice, Transgenic; Myelin Basic Protein; Myelin Sheath; Oligodendroglia; Optic Nerve; Promoter Regions, Genetic; Recombinant Fusion Proteins; RNA, Messenger; Sciatic Nerve; Thymidine Kinase	2000
Simultaneous evaluation of dual gene transfer to adherent cells by gamma-ray imaging. Nuclear medicine and biology, 2001, Volume: 28, Issue:2 Topics: Adenoviridae; Arabinofuranosyluracil; Carcinoma, Non-Small-Cell Lung; Cell Adhesion; Cell Line; Gamma Cameras; Gamma Rays; Genetic Vectors; Herpesviridae; Humans; Iodine Radioisotopes; Kidney; Lung Neoplasms; Radiopharmaceuticals; Receptors, Somatostatin; Technetium; Thymidine Kinase; Transfection; Tumor Cells, Cultured	2001
Positron emission tomography-based imaging of transgene expression mediated by replication-conditional, oncolytic herpes simplex virus type 1 mutant vectors in vivo. Cancer research, 2001, Apr-01, Volume: 61, Issue:7 Topics: Animals; Arabinofuranosyluracil; Autoradiography; Chlorocebus aethiops; Gene Expression Regulation, Viral; Genetic Vectors; Glioma; Gliosarcoma; Herpesvirus 1, Human; Humans; Iodine Radioisotopes; Lac Operon; Mice; Mice, Nude; Mutation; Rats; Thymidine Kinase; Tomography, Emission-Computed; Transgenes; Vero Cells; Virus Replication	2001
Quantitative kinetics of [124I]FIAU in cat and man. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2001, Volume: 42, Issue:3 Topics: Animals; Arabinofuranosyluracil; Blood-Brain Barrier; Brain; Brain Neoplasms; Cats; Gene Expression; Genetic Therapy; Glioblastoma; Herpesvirus 1, Human; Humans; Iodine Radioisotopes; Male; Middle Aged; Neoplasm Recurrence, Local; Radiopharmaceuticals; Thymidine Kinase; Tissue Distribution; Tomography, Emission-Computed; Transduction, Genetic	2001
Positron emission tomography imaging for herpes virus infection: Implications for oncolytic viral treatments of cancer. Nature medicine, 2001, Volume: 7, Issue:7 Topics: Antiviral Agents; Arabinofuranosyluracil; Autoradiography; Biological Therapy; Herpesvirus 1, Human; Humans; Neoplasms; Promoter Regions, Genetic; Thymidine Kinase; Tomography, Emission-Computed; Tumor Cells, Cultured; Virus Replication	2001
Comparison of [18F]FHPG and [124/125I]FIAU for imaging herpes simplex virus type 1 thymidine kinase gene expression. European journal of nuclear medicine, 2001, Volume: 28, Issue:6 Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Cell Line; Cells, Cultured; Enzyme Inhibitors; Ganciclovir; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Viral; Genetic Vectors; Herpesvirus 1, Human; Mice; Mice, Inbred BALB C; Radiopharmaceuticals; Thymidine Kinase; Tissue Distribution; Transfection; Transgenes	2001
Salmonella-based tumor-targeted cancer therapy: tumor amplified protein expression therapy (TAPET) for diagnostic imaging. Journal of controlled release : official journal of the Controlled Release Society, 2001, Jul-06, Volume: 74, Issue:1-3 Topics: Animals; Arabinofuranosyluracil; Genetic Markers; Genetic Vectors; Herpesvirus 1, Human; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neoplasms; Protein-Tyrosine Kinases; Salmonella; Tissue Distribution; Tumor Cells, Cultured	2001
Comparison of radiolabeled nucleoside probes (FIAU, FHBG, and FHPG) for PET imaging of HSV1-tk gene expression. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2002, Volume: 43, Issue:8 Topics: Animals; Arabinofuranosyluracil; Carbon Radioisotopes; Fluorodeoxyglucose F18; Gene Expression; Herpesvirus 1, Human; Iodine Radioisotopes; Nucleosides; Radiopharmaceuticals; Rats; Rats, Nude; Thymidine Kinase; Tomography, Emission-Computed	2002
Imaging expression of adenoviral HSV1-tk suicide gene transfer using the nucleoside analogue FIRU. European journal of nuclear medicine and molecular imaging, 2002, Volume: 29, Issue:7 Topics: Adenoviridae; Animals; Arabinofuranosyluracil; Biomarkers, Tumor; Female; Gene Expression; Gene Expression Regulation, Viral; Gene Transfer Techniques; Genes, Reporter; Genetic Therapy; Genetic Vectors; Glioma; Herpesvirus 1, Human; Humans; Iodine Radioisotopes; Mice; Nucleosides; Radionuclide Imaging; Radiopharmaceuticals; Sensitivity and Specificity; Tissue Distribution; Transduction, Genetic; Transfection; Tumor Cells, Cultured	2002
Serial in vivo imaging of the targeted migration of human HSV-TK-transduced antigen-specific lymphocytes. Nature biotechnology, 2003, Volume: 21, Issue:4 Topics: Animals; Apoptosis; Arabinofuranosyluracil; Biomarkers, Tumor; Cell Line; Cell Movement; Cell Survival; Herpesvirus 4, Human; Humans; Iodine Radioisotopes; Isotope Labeling; Mice; Mice, SCID; Neoplasm Transplantation; Radiopharmaceuticals; Sensitivity and Specificity; Simplexvirus; T-Lymphocytes; Thymidine Kinase; Tissue Distribution; Tomography, Emission-Computed; Transduction, Genetic	2003
Imaging of dihydrofolate reductase fusion gene expression in xenografts of human liver metastases of colorectal cancer in living rats. European journal of nuclear medicine and molecular imaging, 2003, Volume: 30, Issue:9 Topics: Animals; Animals, Genetically Modified; Arabinofuranosyluracil; Cell Line, Tumor; Colorectal Neoplasms; Feasibility Studies; Folic Acid Antagonists; Gene Expression Regulation, Neoplastic; Humans; Iodine Radioisotopes; Liver Neoplasms; Male; Neoplasm Transplantation; Organ Specificity; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Nude; Recombinant Fusion Proteins; Tetrahydrofolate Dehydrogenase; Thymidine Kinase; Tissue Distribution; Transplantation, Heterologous; Viral Proteins; Whole-Body Counting	2003
Synthesis of 2'-deoxy-2'-[18F]fluoro-beta-D-arabinofuranosyl nucleosides, [18F]FAU, [18F]FMAU, [18F]FBAU and [18F]FIAU, as potential PET agents for imaging cellular proliferation. Synthesis of [18F]labelled FAU, FMAU, FBAU, FIAU. Nuclear medicine and biology, 2003, Volume: 30, Issue:3 Topics: Antiviral Agents; Arabinofuranosyluracil; Arabinonucleosides; Fluorine Radioisotopes	2003
Oligodendrocyte ablation impairs cerebellum development. Development (Cambridge, England), 2003, Volume: 130, Issue:19 Topics: Animals; Animals, Newborn; Arabinofuranosyluracil; Astrocytes; Cell Movement; Cerebellum; In Situ Hybridization; Interneurons; Mice; Mice, Transgenic; Oligodendroglia; Phenotype; Purkinje Cells; Time Factors	2003
Non-invasive in vivo imaging with radiolabelled FIAU for monitoring cancer gene therapy using herpes simplex virus type 1 thymidine kinase and ganciclovir. European journal of nuclear medicine and molecular imaging, 2004, Volume: 31, Issue:1 Topics: Animals; Arabinofuranosyluracil; Cell Line, Tumor; Female; Ganciclovir; Genetic Therapy; Iodine Radioisotopes; Isotope Labeling; Metabolic Clearance Rate; Mice; Mice, Inbred Strains; Organ Specificity; Radionuclide Imaging; Radiopharmaceuticals; Sarcoma; Thymidine Kinase; Tissue Distribution; Viral Proteins	2004
Noninvasive imaging of transgene expression by use of positron emission tomography in a pig model of myocardial gene transfer. Circulation, 2003, Oct-28, Volume: 108, Issue:17 Topics: Animals; Arabinofuranosyluracil; Blood Flow Velocity; Coronary Circulation; Feasibility Studies; Gene Expression; Gene Transfer Techniques; Genes, Reporter; Heart; Iodine Radioisotopes; Models, Animal; Myocardium; Swine; Thymidine Kinase; Tomography, Emission-Computed; Transgenes	2003
Comparison of [18F]FHBG and [14C]FIAU for imaging of HSV1-tk reporter gene expression: adenoviral infection vs stable transfection. European journal of nuclear medicine and molecular imaging, 2003, Volume: 30, Issue:11 Topics: Adenoviridae Infections; Animals; Arabinofuranosyluracil; Cell Line, Tumor; Genes, Reporter; Glioma; Guanine; Intracellular Signaling Peptides and Proteins; Male; Metabolic Clearance Rate; Mice; Organ Specificity; Proteins; Radiopharmaceuticals; Rats; Tissue Distribution; Tomography, Emission-Computed; Transfection	2003
Mitochondrial expression of the human equilibrative nucleoside transporter 1 (hENT1) results in enhanced mitochondrial toxicity of antiviral drugs. The Journal of biological chemistry, 2004, Feb-06, Volume: 279, Issue:6 Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Biological Transport, Active; Cell Line; Dogs; Equilibrative Nucleoside Transporter 1; Humans; In Vitro Techniques; Intracellular Membranes; Membrane Transport Proteins; Mitochondria, Liver; Recombinant Fusion Proteins; Subcellular Fractions	2004
A novel triple-modality reporter gene for whole-body fluorescent, bioluminescent, and nuclear noninvasive imaging. European journal of nuclear medicine and molecular imaging, 2004, Volume: 31, Issue:5 Topics: Animals; Arabinofuranosyluracil; Cell Line, Tumor; Gene Transfer Techniques; Genes, Reporter; Glioma; Green Fluorescent Proteins; Humans; Iodine Radioisotopes; Luminescent Proteins; Mice; Mice, Nude; Microscopy, Fluorescence; Protein Engineering; Radionuclide Imaging; Recombinant Fusion Proteins; Thymidine Kinase; Viral Proteins; Whole-Body Counting	2004
A preclinical model for noninvasive imaging of hypoxia-induced gene expression; comparison with an exogenous marker of tumor hypoxia. European journal of nuclear medicine and molecular imaging, 2004, Volume: 31, Issue:11 Topics: Adenocarcinoma; Animals; Arabinofuranosyluracil; Biomarkers, Tumor; Cell Hypoxia; Cell Line, Tumor; Disease Models, Animal; DNA-Binding Proteins; Drug Evaluation, Preclinical; Feasibility Studies; Fluorine Radioisotopes; Gene Expression Profiling; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Iodine Radioisotopes; Misonidazole; Nuclear Proteins; Radionuclide Imaging; Radiopharmaceuticals; Rats; Thymidine Kinase; Transcription Factors; Viral Proteins	2004
PET of cardiac transgene expression: comparison of 2 approaches based on herpesviral thymidine kinase reporter gene. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2004, Volume: 45, Issue:11 Topics: Animals; Arabinofuranosyluracil; Gene Expression Profiling; Gene Transfer Techniques; Genes, Reporter; Genetic Therapy; Guanine; Heart; Iodine Radioisotopes; Male; Myocardium; Positron-Emission Tomography; Rats; Rats, Wistar; Species Specificity; Swine; Thymidine Kinase; Tissue Distribution; Transgenes; Viral Proteins	2004
Myocardial kinetics of reporter probe 124I-FIAU in isolated perfused rat hearts after in vivo adenoviral transfer of herpes simplex virus type 1 thymidine kinase reporter gene. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2005, Volume: 46, Issue:1 Topics: Adenoviridae; Animals; Arabinofuranosyluracil; Computer Simulation; Feasibility Studies; Gene Expression Profiling; Gene Transfer Techniques; Genes, Reporter; Heart; Iodine Radioisotopes; Kinetics; Male; Metabolic Clearance Rate; Models, Cardiovascular; Myocardium; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Wistar; Recombinant Proteins; Thymidine Kinase; Transfection; Viral Proteins	2005
Imaging bacterial infections with radiolabeled 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodouracil. Proceedings of the National Academy of Sciences of the United States of America, 2005, Jan-25, Volume: 102, Issue:4 Topics: Amino Acid Sequence; Animals; Arabinofuranosyluracil; Cell Line; Escherichia coli; Escherichia coli Infections; Humans; Iodine Radioisotopes; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Radionuclide Imaging; Thymidine Kinase	2005
Identification of the mitochondrial targeting signal of the human equilibrative nucleoside transporter 1 (hENT1): implications for interspecies differences in mitochondrial toxicity of fialuridine. The Journal of biological chemistry, 2006, Jun-16, Volume: 281, Issue:24 Topics: Amino Acid Sequence; Animals; Arabinofuranosyluracil; Biological Transport; Cell Line; Dogs; Equilibrative Nucleoside Transporter 1; Mice; Mitochondria; Molecular Sequence Data; Mutation; Protein Structure, Tertiary; Rats; Species Specificity	2006
[131I]FIAU labeling of genetically transduced, tumor-reactive lymphocytes: cell-level dosimetry and dose-dependent toxicity. European journal of nuclear medicine and molecular imaging, 2006, Volume: 33, Issue:9 Topics: Animals; Arabinofuranosyluracil; Cytotoxicity, Immunologic; Dose-Response Relationship, Radiation; Epstein-Barr Virus Infections; Hematologic Neoplasms; Humans; Immunotherapy, Adoptive; In Vitro Techniques; Iodine Radioisotopes; Mice; Mice, SCID; Radionuclide Imaging; Radiopharmaceuticals; T-Lymphocytes; Transduction, Genetic	2006
Molecular imaging with 123I-FIAU, 18F-FUdR, 18F-FET, and 18F-FDG for monitoring herpes simplex virus type 1 thymidine kinase and ganciclovir prodrug activation gene therapy of cancer. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2006, Volume: 47, Issue:7 Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Cell Line, Tumor; Female; Floxuridine; Fluorodeoxyglucose F18; Ganciclovir; Genetic Therapy; Herpesvirus 1, Human; Humans; Iodine Radioisotopes; Mice; Neoplasms; Prodrugs; Thymidine Kinase; Tyrosine	2006
In vitro evaluation of herpes simplex virus type 1 thymidine kinase reporter system in dynamic studies of transcriptional gene regulation. Nuclear medicine and biology, 2006, Volume: 33, Issue:5 Topics: Arabinofuranosyluracil; Cell Line, Tumor; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Transfer Techniques; Genes, Reporter; Humans; Radionuclide Imaging; Radiopharmaceuticals; Sarcoma; Thymidine Kinase; Transcription Factors; Transcription, Genetic; Viral Proteins	2006
Virus-associated tumor imaging by induction of viral gene expression. Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, Mar-01, Volume: 13, Issue:5 Topics: Animals; Antineoplastic Agents; Arabinofuranosyluracil; Boronic Acids; Bortezomib; Burkitt Lymphoma; Diagnostic Imaging; Gene Expression; Gene Transfer Techniques; Genes, Viral; Herpesvirus 4, Human; Humans; Immunoblotting; Mice; Neoplasms, Experimental; Oncogenic Viruses; Pyrazines; Radionuclide Imaging; Radiopharmaceuticals; Reverse Transcriptase Polymerase Chain Reaction; Thymidine Kinase	2007
Biodistribution, PET, and radiation dosimetry estimates of HSV-tk gene expression imaging agent 1-(2'-Deoxy-2'-18F-Fluoro-beta-D-arabinofuranosyl)-5-iodouracil in normal dogs. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2007, Volume: 48, Issue:4 Topics: Animals; Arabinofuranosyluracil; DNA; Dogs; Fluorine Radioisotopes; Gene Expression Regulation; Genes, Reporter; Genetic Therapy; Kinetics; Liver; Positron-Emission Tomography; Radiometry; Simplexvirus; Thymidine Kinase; Tissue Distribution	2007
Imaging of musculoskeletal bacterial infections by [124I]FIAU-PET/CT. PloS one, 2007, Oct-10, Volume: 2, Issue:10 Topics: Arabinofuranosyluracil; Bacteria; Bacterial Infections; Bone and Bones; Case-Control Studies; Diagnostic Imaging; Humans; Muscles; Positron-Emission Tomography; Radiopharmaceuticals; Substrate Specificity; Thymidine Kinase; Tomography, X-Ray Computed	2007
Imaging of gene expression in live pancreatic islet cell lines using dual-isotope SPECT. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2008, Volume: 49, Issue:1 Topics: Animals; Arabinofuranosyluracil; Cell Line; Genes, Reporter; Glucagon-Secreting Cells; Green Fluorescent Proteins; Indium Radioisotopes; Insulin-Secreting Cells; Iodine Radioisotopes; Mice; Radiopharmaceuticals; Thymidine Kinase; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; Tropolone	2008
In vivo evaluation of the uptake of [(123)I]FIAU, [(123)I]IVFRU and [(123)I]IVFAU by normal mouse brain: potential for noninvasive assessment of HSV-1 thymidine kinase gene expression in gliomas. Nucleosides, nucleotides & nucleic acids, 2008, Volume: 27, Issue:1 Topics: Animals; Arabinofuranosyluracil; Blood-Brain Barrier; Brain; Brain Neoplasms; Floxuridine; Gene Expression; Glioma; Herpesvirus 1, Human; Iodine Radioisotopes; Male; Mice; Mice, Nude; Thymidine Kinase; Tissue Distribution; Uridine	2008
Biodistribution, cellular uptake and DNA-incorporation of the 2'-fluoro stabilized 5-iodo-2'-deoxyuridine analog 5-iodo-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil (FIAU). The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of..., 2008, Volume: 52, Issue:3 Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Cell Line, Tumor; Chemistry, Pharmaceutical; DNA; HL-60 Cells; Humans; Mice; Mice, SCID; Neoplasm Transplantation; Phosphorylation; Thymidine Kinase; Thymidine Phosphorylase; Tissue Distribution	2008
Human breast tumor cells express multimodal imaging reporter genes. Molecular imaging and biology, 2008, Volume: 10, Issue:5 Topics: Animals; Arabinofuranosyluracil; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Ganciclovir; Genes, Reporter; Genetic Vectors; Glucose; Humans; Mice; Mice, Inbred ICR; Mice, Nude; Positron-Emission Tomography; Substrate Specificity; Tomography, X-Ray Computed; Xenograft Model Antitumor Assays	2008
Expression and hepatobiliary transport characteristics of the concentrative and equilibrative nucleoside transporters in sandwich-cultured human hepatocytes. American journal of physiology. Gastrointestinal and liver physiology, 2008, Volume: 295, Issue:3 Topics: Adult; Aged; Arabinofuranosyluracil; Bile; Cell Culture Techniques; Cell Membrane; Cells, Cultured; Equilibrative Nucleoside Transporter 1; Equilibrative-Nucleoside Transporter 2; Female; Formycins; Guanosine; Hepatocytes; Humans; Male; Membrane Transport Proteins; Middle Aged; Nucleosides; Ribavirin; RNA, Messenger; Thymidine	2008
Bortezomib-induced enzyme-targeted radiation therapy in herpesvirus-associated tumors. Nature medicine, 2008, Volume: 14, Issue:10 Topics: Animals; Antineoplastic Agents; Arabinofuranosyluracil; Boronic Acids; Bortezomib; Burkitt Lymphoma; Cell Line, Tumor; Herpesviridae Infections; Herpesvirus 4, Human; Humans; Iodine Radioisotopes; Male; Mice; Mice, SCID; Pyrazines; Radiopharmaceuticals; Sarcoma, Kaposi; Stomach Neoplasms; Thymidine Kinase	2008
Noninvasive molecular imaging of hypoxia in human xenografts: comparing hypoxia-induced gene expression with endogenous and exogenous hypoxia markers. Cancer research, 2008, Oct-15, Volume: 68, Issue:20 Topics: Animals; Antigens, Neoplasm; Arabinofuranosyluracil; Autoradiography; Biomarkers; Carbonic Anhydrase IX; Carbonic Anhydrases; Cell Hypoxia; Etanidazole; Female; Gene Expression; Green Fluorescent Proteins; Herpesvirus 1, Human; HT29 Cells; Humans; Hydrocarbons, Fluorinated; Immunohistochemistry; Mice; Mice, Nude; Misonidazole; Neoplasm Transplantation; Neoplasms; Nitroimidazoles; Positron-Emission Tomography; Thymidine Kinase; Tissue Distribution; Transplantation, Heterologous	2008
5-[18F]Fluoroalkyl pyrimidine nucleosides: probes for positron emission tomography imaging of herpes simplex virus type 1 thymidine kinase gene expression. Nuclear medicine and biology, 2009, Volume: 36, Issue:1 Topics: Animals; Arabinofuranosyluracil; Cell Line, Tumor; Fluorine Radioisotopes; Gene Expression; Genes, Reporter; Glioma; Herpesvirus 1, Human; Male; Mice; Mice, Nude; Positron-Emission Tomography; Pyrimidine Nucleosides; Rats; Reproducibility of Results; Sensitivity and Specificity; Thymidine Kinase; Time Factors; Tissue Distribution; Transplantation, Heterologous	2009
Comparative study of cellular kinetics of reporter probe [(131)I]FIAU in neonatal cardiac myocytes after transfer of HSV1-tk reporter gene with two vectors. Nuclear medicine and biology, 2009, Volume: 36, Issue:2 Topics: Adenoviridae; Animals; Animals, Newborn; Arabinofuranosyluracil; Cells, Cultured; Gene Transfer Techniques; Genetic Therapy; Herpesvirus 1, Human; Immunohistochemistry; Iodine Radioisotopes; Isotope Labeling; Liposomes; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Thymidine Kinase	2009
Herpes simplex virus thymidine kinase imaging in mice with (1-(2'-deoxy-2'-[18F]fluoro-1-β-D-arabinofuranosyl)-5-iodouracil) and metabolite (1-(2'-deoxy-2'-[18F]fluoro-1-β-D-arabinofuranosyl)-5-uracil). European journal of nuclear medicine and molecular imaging, 2009, Volume: 36, Issue:12 Topics: Animals; Arabinofuranosyluracil; Biological Transport; Cell Line, Tumor; Fluorine Radioisotopes; Gene Expression Regulation, Enzymologic; Humans; Male; Mice; Molecular Imaging; Rats; Simplexvirus; Substrate Specificity; Thymidine Kinase	2009
Bacterial thymidine kinase as a non-invasive imaging reporter for Mycobacterium tuberculosis in live animals. PloS one, 2009, Jul-16, Volume: 4, Issue:7 Topics: Animals; Arabinofuranosyluracil; Chromosomes, Bacterial; Female; Iodine Radioisotopes; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Promoter Regions, Genetic; Thymidine Kinase	2009
Letter to the editor. Seminars in nuclear medicine, 2009, Volume: 39, Issue:5 Topics: Arabinofuranosyluracil; Bacterial Infections; Clinical Trials as Topic; Diagnostic Imaging; Humans; Liver Failure	2009
Enhanced antitumor effects by combination gene therapy using MDR1 gene shRNA and HSV1-tk in a xenograft mouse model. Cancer letters, 2010, May-01, Volume: 291, Issue:1 Topics: Animals; Arabinofuranosyluracil; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Colonic Neoplasms; Doxorubicin; Ganciclovir; Genetic Therapy; Herpesvirus 1, Human; Humans; Male; Mice; Mice, Inbred BALB C; RNA, Small Interfering; Thymidine Kinase; Xenograft Model Antitumor Assays	2010
Effects of structural differences between radioiodine-labeled 1-(2'-fluoro-2'-deoxy-D-arabinofuranosyl)-5-iodouracil (FIAU) and 1-(2'-fluoro-2'-deoxy-d-ribofuranosyl)-5-iodouracil (FIRU) on HSV1-TK reporter gene imaging. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2010, Volume: 68, Issue:6 Topics: Animals; Arabinofuranosyluracil; Floxuridine; Genes, Reporter; Herpesvirus 1, Human; Iodine Radioisotopes; Mice; Protein-Tyrosine Kinases; Viral Proteins	2010
Improved synthesis of 2'-deoxy-2'-[18F]-fluoro-1-beta-D-arabinofuranosyl-5-iodouracil ([18F]-FIAU). Nuclear medicine and biology, 2010, Volume: 37, Issue:4 Topics: Arabinofuranosyluracil; Catalysis; Fluorine Radioisotopes; Kinetics; Mesylates; Trimethylsilyl Compounds	2010
In vivo trafficking and immunostimulatory potential of an intranasally-administered primary dendritic cell-based vaccine. BMC immunology, 2010, Dec-10, Volume: 11 Topics: Administration, Intranasal; Animals; Arabinofuranosyluracil; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Shape; Cells, Cultured; Coccidioides; Cytokines; Dendritic Cells; DNA, Complementary; Epitopes; Fungal Vaccines; Immunization; Immunologic Memory; Immunophenotyping; Lymphocyte Activation; Mice; Models, Animal; Molecular Imaging; Plasmids; Thymidine Kinase; Tissue Distribution; Transfection; Transgenes	2010
The improved syntheses of 5-substituted 2'-[18F]fluoro-2'-deoxy-arabinofuranosyluracil derivatives ([18F]FAU, [18F]FEAU, [18F]FFAU, [18F]FCAU, [18F]FBAU and [18F]FIAU) using a multistep one-pot strategy. Nuclear medicine and biology, 2011, Volume: 38, Issue:5 Topics: Arabinofuranosyluracil; Bromouracil; Fluorouracil; Radiochemistry; Reference Standards	2011
Evaluation of F-18-labeled 5-iodocytidine (18F-FIAC) as a new potential positron emission tomography probe for herpes simplex virus type 1 thymidine kinase imaging. Nuclear medicine and biology, 2011, Volume: 38, Issue:7 Topics: Animals; Arabinofuranosyluracil; Cell Line, Tumor; Cytarabine; Female; Fluorine Radioisotopes; Herpesvirus 1, Human; Mice; Positron-Emission Tomography; Sarcoma; Thymidine Kinase; Transfection	2011
Imaging of a localized bacterial infection with endogenous thymidine kinase using radioisotope-labeled nucleosides. International journal of medical microbiology : IJMM, 2012, Volume: 302, Issue:2 Topics: Animals; Arabinofuranosyluracil; Bacterial Infections; Dideoxynucleosides; Focal Infection; Gene Expression; Iodine Radioisotopes; Mice; Mice, Inbred BALB C; Molecular Imaging; Positron-Emission Tomography; Radiopharmaceuticals; Salmonella typhimurium; Thymidine Kinase; Tomography, Emission-Computed, Single-Photon	2012
A multimodality reporter gene for monitoring transplanted stem cells. Nuclear medicine and biology, 2012, Volume: 39, Issue:6 Topics: Adenoviridae; Animals; Arabinofuranosyluracil; Biological Transport; Bone Marrow Cells; Genes, Reporter; Green Fluorescent Proteins; Herpesvirus 1, Human; Luciferases, Firefly; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Molecular Imaging; Radionuclide Imaging; Rats; Rats, Sprague-Dawley; Thymidine Kinase; Transfection	2012
Comparison of cell-labeling methods with ¹²⁴I-FIAU and ⁶⁴Cu-PTSM for cell tracking using chronic myelogenous leukemia cells expressing HSV1-tk and firefly luciferase. Cancer biotherapy & radiopharmaceuticals, 2012, Volume: 27, Issue:10 Topics: Animals; Arabinofuranosyluracil; Cell Tracking; Copper Radioisotopes; Female; Gene Transfer Techniques; Herpesvirus 1, Human; Humans; Iodine Radioisotopes; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Luciferases, Firefly; Mice; Mice, Inbred BALB C; Mice, Nude; Organometallic Compounds; Positron-Emission Tomography; Radiopharmaceuticals; Thiosemicarbazones; Thymidine Kinase; Transplantation, Heterologous	2012
Monitoring bone marrow stem cells with a reporter gene system in experimental middle cerebral artery occlusion rat models. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2013, Volume: 54, Issue:6 Topics: Animals; Arabinofuranosyluracil; Autoradiography; Behavior, Animal; Bone Marrow Cells; Disease Models, Animal; Feasibility Studies; Genes, Reporter; Herpesvirus 1, Human; Infarction, Middle Cerebral Artery; Isotope Labeling; Male; Rats; Rats, Sprague-Dawley; Stem Cell Transplantation; Stem Cells; Thymidine Kinase; Tomography, Emission-Computed, Single-Photon	2013
The use of 14C-FIAU to predict bacterial thymidine kinase presence: implications for radiolabeled FIAU bacterial imaging. Nuclear medicine and biology, 2013, Volume: 40, Issue:5 Topics: Arabinofuranosyluracil; Bacteria; Biological Transport; Carbon Radioisotopes; Granulomatous Disease, Chronic; Humans; Isotope Labeling; Job Syndrome; Molecular Imaging; Positron-Emission Tomography; Thymidine Kinase	2013
Efficient targeting and tumor retardation effect of pancreatic adenocarcinoma up-regulated factor (PAUF)-specific RNA replacement in pancreatic cancer mouse model. Cancer letters, 2014, Mar-28, Volume: 344, Issue:2 Topics: Adenocarcinoma; Adenoviridae; Animals; Arabinofuranosyluracil; Cell Line, Tumor; Female; Genetic Therapy; Humans; Intercellular Signaling Peptides and Proteins; Iodine Radioisotopes; Lectins; Mice; Mice, Inbred BALB C; Pancreatic Neoplasms; Random Allocation; RNA; RNA, Catalytic; Thymidine Kinase; Tomography, Emission-Computed, Single-Photon; Transgenes; Xenograft Model Antitumor Assays	2014
Fialuridine induces acute liver failure in chimeric TK-NOG mice: a model for detecting hepatic drug toxicity prior to human testing. PLoS medicine, 2014, Volume: 11, Issue:4 Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Chimera; Drug Evaluation, Preclinical; Female; Humans; Liver; Liver Failure, Acute; Male; Mice; Models, Animal; Toxicity Tests	2014
Toxicology. 'Humanized' mouse detects deadly drug side effects. Science (New York, N.Y.), 2014, Apr-18, Volume: 344, Issue:6181 Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Chimera; Hepatocytes; Humans; Liver; Liver Transplantation; Mice; Mice, Transgenic; Models, Animal; Toxicity Tests	2014
Evaluation of 1-(2-deoxy-2-fluoro-1-D-arabinofuranosyl)-5-iodouracil (FIAU) as an ex vivo bacterial detection agent. World journal of microbiology & biotechnology, 2014, Volume: 30, Issue:11 Topics: Arabinofuranosyluracil; Bacteria; Bacterial Infections; Bacteriological Techniques; Diagnostic Errors; Humans; Point-of-Care Systems; Radiometry; Urinary Tract Infections; Urine	2014
Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease. Scientific reports, 2016, 05-04, Volume: 6 Topics: Arabinofuranosyluracil; Cells, Cultured; Chemical and Drug Induced Liver Injury; Hepatocytes; Humans; Models, Biological; Proof of Concept Study; Proteome; Spheroids, Cellular	2016
Integrated in vitro models for hepatic safety and metabolism: evaluation of a human Liver-Chip and liver spheroid. Archives of toxicology, 2019, Volume: 93, Issue:4 Topics: Acetaminophen; Arabinofuranosyluracil; Biomarkers; Cell Culture Techniques; Cell Survival; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Glutathione Transferase; Hepatocytes; Humans; Liver; Models, Biological; Spheroids, Cellular	2019
The utility of a differentiated preclinical liver model, HepaRG cells, in investigating delayed toxicity via inhibition of mitochondrial-replication induced by fialuridine. Toxicology and applied pharmacology, 2020, 09-15, Volume: 403 Topics: Antiviral Agents; Arabinofuranosyluracil; Cell Line, Tumor; DNA Replication; DNA, Mitochondrial; Dose-Response Relationship, Drug; Hepatocytes; Humans; Mitochondria	2020
Characterization of primary mouse hepatocyte spheroids as a model system to support investigations of drug-induced liver injury. Toxicology in vitro : an international journal published in association with BIBRA, 2021, Volume: 70 Topics: Acetaminophen; Adenosine Triphosphate; Albumins; Animals; Arabinofuranosyluracil; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Female; Hepatocytes; Male; Mice, Inbred C57BL; Models, Biological; Phenylacetates; Proteomics; Spheroids, Cellular; Sulfonamides; Tolvaptan; Transcriptome	2021