aq-ra 741 has been researched along with methoctramine in 6 studies
| Studies (aq-ra 741) | Trials (aq-ra 741) | Recent Studies (post-2010) (aq-ra 741) | Studies (methoctramine) | Trials (methoctramine) | Recent Studies (post-2010) (methoctramine) |
|---|---|---|---|---|---|
| 25 | 0 | 3 | 40 | 0 | 15 |
| 25 | 0 | 3 | 332 | 1 | 32 |
| Protein | Taxonomy | aq-ra 741 (IC50) | methoctramine (IC50) |
|---|---|---|---|
| Cholinesterase | Homo sapiens (human) | 0.9772 | |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | 0.0407 | |
| Acetylcholinesterase | Homo sapiens (human) | 5.3703 | |
| Glutamate receptor ionotropic, NMDA 1 | Homo sapiens (human) | 0.138 | |
| Glutamate receptor ionotropic, NMDA 2A | Homo sapiens (human) | 0.138 | |
| Carboxylic ester hydrolase | Rattus norvegicus (Norway rat) | 0.9772 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (83.33) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brann, MR; Dörje, F; Lambrecht, G; Mutschler, E; Tacke, R; Wess, J | 1 |
| Bolognesi, ML; Budriesi, R; Canossa, M; Chiarini, A; Melchiorre, C; Minarini, A; Spampinato, S | 1 |
| Bolognesi, ML; Chiarini, A; Melchiorre, C; Minarini, A; Spampinato, S | 1 |
| Hamstra, JJ; Roffel, AF; Santing, RE; ten Berge, RE; Zaagsma, J | 1 |
| Budriesi, R; Chiarini, A; Melchiorre, C; Minarini, A; Spampinato, S; Tumiatti, V | 1 |
| Daniels, DV; Eglen, RM; Ford, AP; Hegde, SS; Meloy, TD | 1 |
6 other study(ies) available for aq-ra 741 and methoctramine
| Article | Year |
|---|---|
Antagonist binding profiles of five cloned human muscarinic receptor subtypes.
Topics: Animals; Cells, Cultured; Cricetinae; Humans; N-Methylscopolamine; Parasympatholytics; Receptors, Muscarinic; Scopolamine Derivatives; Transfection | 1991 |
Design, synthesis, and biological activity of methoctramine-related tetraamines bearing an 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4] benzodiazepin-6-one moiety: structural requirements for optimum occupancy of muscarinic receptor subtypes as revealed b
Topics: Animals; Atrial Function; Benzodiazepines; Cells, Cultured; Cerebral Cortex; Drug Design; Female; Guinea Pigs; Heart Atria; Ileum; Male; Molecular Structure; Muscarinic Antagonists; Muscle Contraction; Myocardial Contraction; Myocardium; Polyamines; Rats; Receptors, Muscarinic; Structure-Activity Relationship; Submandibular Gland | 1994 |
Synthesis and biological activity of some methoctramine-related tetraamines bearing a 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]-benzodiazepin-6-one moiety as antimuscarinics: a second generation of highly selective M2 muscarinic receptor antagonists.
Topics: Animals; Benzodiazepines; Diamines; Guinea Pigs; Molecular Structure; Muscarinic Antagonists; Rats; Receptors, Muscarinic; Structure-Activity Relationship | 1993 |
Dysfunction of muscarinic M2 receptors after the early allergic reaction: possible contribution to bronchial hyperresponsiveness in allergic guinea-pigs.
Topics: Administration, Inhalation; Allergens; Animals; Asthma; Benzodiazepinones; Bronchial Hyperreactivity; Diamines; Disease Models, Animal; Electric Stimulation; Female; Gallamine Triethiodide; Guinea Pigs; Heart; Histamine; Hypersensitivity; In Vitro Techniques; Male; Muscarinic Antagonists; Muscle, Smooth; Neuromuscular Junction; Parasympatholytics; Pilocarpine; Piperidines; Pirenzepine; Receptors, Muscarinic; Trachea | 1995 |
The design of novel methoctramine-related tetraamines as muscarinic receptor subtype selective antagonists.
Topics: Animals; Atrial Function; Benzodiazepines; Benzodiazepinones; Diamines; Drug Design; Guinea Pigs; Heart Atria; Ileum; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Piperidines; Pirenzepine; Rats; Receptors, Muscarinic; Structure-Activity Relationship; Submandibular Gland; Trachea | 1995 |
Functional characterization of rat submaxillary gland muscarinic receptors using microphysiometry.
Topics: Alkaloids; Animals; Atropine; Benzhydryl Compounds; Benzodiazepinones; Binding, Competitive; Biosensing Techniques; Carbachol; Cholinergic Agonists; Cresols; Diamines; Dose-Response Relationship, Drug; Furans; Male; Mandelic Acids; Muscarinic Antagonists; Naphthalenes; Phenethylamines; Phenylpropanolamine; Piperidines; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Submandibular Gland; Tolterodine Tartrate | 2001 |