apyrase and cadmium-acetate

apyrase has been researched along with cadmium-acetate* in 1 studies

Other Studies

1 other study(ies) available for apyrase and cadmium-acetate

ArticleYear
Inhibitory effect of cadmium acetate on synaptosomal ATP diphosphohydrolase (EC 3.6.1.5; apyrase) from adult rat cerebral cortex.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1994, Volume: 27, Issue:5

    ATP diphosphohydrolase (EC 3.6.1.5; apyrase) is an enzyme that can promote ATP and ADP hydrolysis to AMP plus inorganic phosphate and depends on divalent cations such as Ca2+ or Mg2+. In previous papers we described this enzyme in the synaptosomal fraction from the central and peripheral nervous system. The present report examines whether cadmium acetate could affect the in vitro activity of the enzyme in the synaptosomal fraction from the cerebral cortex of adult male Wistar rats. Cadmium (Cd2+), a heavy metal with neurotoxic effects, inhibited the enzyme in a concentration-dependent manner. All concentrations tested (0.05-1.0 mM) significantly inhibited the hydrolysis of both substrates (ATP and ADP), with the exception of 0.05 mM on ATP hydrolysis. The kinetic data indicate a noncompetitive inhibition between the cations Cd2+ and Ca2+.

    Topics: Acetates; Adenosine Diphosphate; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Apyrase; Cadmium; Cerebral Cortex; Hydrolysis; Kinetics; Male; Rats; Rats, Wistar; Substrate Specificity; Synaptosomes

1994