apovincaminic acid has been researched along with vinpocetine in 20 studies
| Studies (apovincaminic acid) | Trials (apovincaminic acid) | Recent Studies (post-2010) (apovincaminic acid) | Studies (vinpocetine) | Trials (vinpocetine) | Recent Studies (post-2010) (vinpocetine) |
|---|---|---|---|---|---|
| 31 | 2 | 4 | 652 | 62 | 212 |
| Protein | Taxonomy | apovincaminic acid (IC50) | vinpocetine (IC50) |
|---|---|---|---|
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | Homo sapiens (human) | 7.99 | |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 0.039 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (20.00) | 18.7374 |
| 1990's | 5 (25.00) | 18.2507 |
| 2000's | 6 (30.00) | 29.6817 |
| 2010's | 5 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Czibula, L; Gere, A; Gyertyán, I; Kiss, B; Laszy, J; Nemes, A; Szántay, C; Szombathelyi, Z | 1 |
| Mazák, K; Noszál, B | 1 |
| Dingler, E; Lohmann, A; Reck, B | 1 |
| Dingler, E; Grobara, P; Lohmann, A | 1 |
| Hammes, W; Weyhenmeyer, R | 1 |
| Fitos, I; Simonyi, M; Visy, J | 1 |
| Göndöc, C; Miskolczi, P; Szalay, L; Vereczkey, L | 1 |
| Hirata, M; Imamoto, T; Kawazoe, K; Shimamoto, N; Tanabe, M | 1 |
| Kozma, M; Pudleiner, P; Vereczkey, L | 1 |
| Polgár, M; Vereczkey, L | 1 |
| Mazák, K; Nemes, A; Noszál, B | 1 |
| Dézsi, L; Kárpáti, E; Kis-Varga, I; Komlódi, Z; Nagy, J | 1 |
| Károly, M; Nemes, A; Noszál, B; Rácz, A; Vámos, J | 1 |
| Bodiu, B; Leucuta, SE; Vlase, L | 1 |
| Imre, S; Leucuta, S; Vlase, L | 1 |
| Felszeghy, K; Keijser, JN; Luiten, PG; Nyakas, C; Szabó, R; Szombathelyi, Z; Tihanyi, K | 1 |
| Chen, J; Guo, JW; Jiang, XG; Liu, GM; Pang, ZQ; Su, LN; Xia, HM | 1 |
| Makarova, LM; Mirzoian, RS; Pogorelyĭ, VE; Prikhod'ko, MA; Skachilova, SIa | 1 |
| Burback, B; Catlin, N; Gibbs, S; McIntyre, BS; Mutlu, E; South, N; Toy, H; Waidyanatha, S | 1 |
| Sun, J; Wang, L; Wang, M; Xiong, Z; Zhang, L; Zhao, L | 1 |
1 trial(s) available for apovincaminic acid and vinpocetine
| Article | Year |
|---|---|
Pharmacokinetics and comparative bioavailability of two vinpocetine tablet formulations in healthy volunteers by using the metabolite apovincaminic acid as pharmacokinetic parameter.
Topics: Adult; Area Under Curve; Biological Availability; Calibration; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Cross-Over Studies; Half-Life; Humans; Male; Tablets; Therapeutic Equivalency; Vinca Alkaloids | 2005 |
19 other study(ies) available for apovincaminic acid and vinpocetine
| Article | Year |
|---|---|
Synthesis and evaluation of 2'-hydroxyethyl trans-apovincaminate derivatives as antioxidant and cognitive enhancer agents.
Topics: Animals; Antioxidants; Avoidance Learning; Brain; In Vitro Techniques; Lipid Peroxidation; Male; Maze Learning; Memory; Mice; Microsomes; Neuroprotective Agents; Nootropic Agents; Rats; Rats, Wistar; Stereoisomerism; Structure-Activity Relationship; Vinca Alkaloids | 2008 |
Zwitterions can be predominant in membrane penetration of drugs: experimental proof.
Topics: Cell Membrane Permeability; Ions; Octanols; Osmolar Concentration; Solutions; Stereoisomerism; Structure-Activity Relationship; Vinca Alkaloids; Water | 2012 |
Development of a sensitive enzyme immunoassay for the determination of vinpocetine in human plasma.
Topics: Antibody Specificity; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Gas Chromatography-Mass Spectrometry; Humans; Immunoenzyme Techniques; Vinca Alkaloids | 1992 |
Investigation of the possible influence of the absorption of vinpocetine with concomitant application of magnesium-aluminium-hydroxide gel.
Topics: Adult; Aluminum Hydroxide; Antacids; Biological Availability; Circadian Rhythm; Drug Combinations; Humans; Intestinal Absorption; Magnesium Hydroxide; Male; Vinca Alkaloids | 1991 |
New assay method for the determination of vinpocetine in human plasma by gas chromatography-mass spectrometry without transesterification caused by solvents: a reply.
Topics: 1-Propanol; Esters; Ethanol; Gas Chromatography-Mass Spectrometry; Humans; Methanol; Solvents; Vinca Alkaloids | 1991 |
Binding of vinca alkaloid analogues to human serum albumin and to alpha 1-acid glycoprotein.
Topics: Binding Sites; Binding, Competitive; Chromatography, Affinity; Esters; Humans; Indoles; Orosomucoid; Serum Albumin; Stereoisomerism; Structure-Activity Relationship; Vinca Alkaloids | 1991 |
Effect of age on the pharmacokinetics of vinpocetine (Cavinton) and apovincaminic acid.
Topics: Adult; Aged; Aging; Blood Proteins; Humans; Infusions, Intravenous; Middle Aged; Vasodilator Agents; Vinca Alkaloids | 1987 |
Cerebral circulatory and cardiac effects of vinpocetine and its metabolite, apovincaminic acid, in anesthetized dogs.
Topics: Anesthesia; Animals; Cerebrovascular Circulation; Dogs; Female; Heart; Hemodynamics; Injections, Intra-Arterial; Injections, Intravenous; Intubation, Gastrointestinal; Male; Vasodilator Agents; Vinca Alkaloids | 1984 |
Determination of apovincaminic acid in biological samples by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Humans; Reference Values; Time Factors; Vinca Alkaloids | 1982 |
Determination of apovincaminic acid in human plasma by gas-liquid chromatography.
Topics: Cerebrovascular Disorders; Chromatography, Gas; Humans; Time Factors; Vasodilator Agents; Vinca Alkaloids | 1982 |
Proton speciation and microspeciation of vinpocetine and related compounds in aqueous and biomimetic media.
Topics: Hydrogen-Ion Concentration; Methanol; Models, Biological; Protein Binding; Protons; Stereoisomerism; Titrimetry; Ultraviolet Rays; Vinca Alkaloids; Vincamine; Water | 1999 |
[Neuroprotective effects of vinpocetine in vivo and in vitro. Apovincaminic acid derivatives as potential therapeutic tools in ischemic stroke].
Topics: Animals; Brain Ischemia; Disease Models, Animal; Humans; Ischemic Attack, Transient; Neuroprotective Agents; Rats; Stroke; Structure-Activity Relationship; Vinca Alkaloids | 2002 |
Lipophilicity of vinpocetine and related compounds characterized by reversed-phase thin-layer chromatography.
Topics: Calibration; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Lipids; Molecular Conformation; Quantitative Structure-Activity Relationship; Solubility; Solvents; Vinca Alkaloids; Vincamine | 2003 |
New HPLC-MS method for quantitative determination of apovincaminic acid in human plasma.
Topics: Chromatography, High Pressure Liquid; Humans; Mass Spectrometry; Molecular Structure; Vinca Alkaloids | 2006 |
Neuroprotective effects of vinpocetine and its major metabolite cis-apovincaminic acid on NMDA-induced neurotoxicity in a rat entorhinal cortex lesion model.
Topics: Animals; Disease Models, Animal; Entorhinal Cortex; Male; Maze Learning; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Wistar; Vinca Alkaloids | 2009 |
Determination of vinpocetine and its primary metabolite, apovincaminic acid, in rat plasma by liquid chromatography-tandem mass spectrometry.
Topics: Animals; Chromatography, Liquid; Female; Male; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Vinca Alkaloids | 2010 |
[Effect of a new derivative of glutamic and apovincaminic acids on brain metabolism in post-ischemic period].
Topics: Acidosis, Lactic; Animals; Blood Glucose; Brain; Brain Ischemia; Cats; Glutamic Acid; Glycine; Lactic Acid; Neuroprotective Agents; Oxygen Consumption; Reperfusion Injury; Vinca Alkaloids | 2014 |
Systemic exposure of vinpocetine in pregnant Sprague Dawley rats following repeated oral exposure: An investigation of fetal transfer.
Topics: Amniotic Fluid; Animals; Area Under Curve; Female; Maternal-Fetal Exchange; Pregnancy; Rats; Rats, Sprague-Dawley; Vinca Alkaloids | 2018 |
Simultaneous Determination of Vinpocetine and its Major Active Metabolite Apovincaminic Acid in Rats by UPLC-MS/MS and its Application to the Brain Tissue Distribution Study.
Topics: Animals; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Linear Models; Male; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Tissue Distribution; Vinca Alkaloids | 2018 |