apomorphine has been researched along with spiperone in 407 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 325 (79.85) | 18.7374 |
| 1990's | 62 (15.23) | 18.2507 |
| 2000's | 18 (4.42) | 29.6817 |
| 2010's | 2 (0.49) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| George, SR; Guan, HC; Laurier, LG; Ng, G; Niznik, HB; O'Dowd, BF; Seeman, P; Sunahara, RK; Torchia, J; Van Tol, HH | 1 |
| Bouthenet, ML; Giros, B; Martres, MP; Schwartz, JC; Sokoloff, P | 1 |
| Billings, J; Chumpradit, S; Kung, HF; Kung, MP; Pan, S | 1 |
| Bhatnagar, RK; Cannon, JG; Jackson, H; Leonard, P; Long, JP | 1 |
| Andrews, PR; Craik, DJ; Martin, JL | 1 |
| Chen, X; Liu, Z; Yu, L; Zhang, A; Zhen, X | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Dismukes, K; Mulder, AH | 1 |
| Arbilla, S; Briley, MS; Dubocovich, ML; Langer, SZ | 1 |
| Anand, N; Humber, L; Jain, PC; Jílek, J; Philipp, A; Protiva, M; Saxena, AK; Seeman, P; Westman, K | 1 |
| Creese, I; Snyder, SH | 1 |
| Mora, F; Phillips, AG; Rolls, ET | 1 |
| Carmichael, R; Di Paolo, T; Labrie, F; Raynaud, JP | 1 |
| Gaillard, JM; Kafi, S | 1 |
| Giachetti, A; Hefco, E; Jameson, HE; Krulich, L; Marchlewska-Koj, A | 1 |
| Seeman, P; Whitaker, PM | 1 |
| Clement-Cormier, YC; George, RJ | 1 |
| Creese, I; Snyder, SH; Usdin, T | 1 |
| Poat, JA; Seeman, P; Woodruff, GN | 1 |
| List, SJ; Seeman, P | 1 |
| Seeman, P; Titeler, M | 3 |
| Creese, I; Snyder, SH; Usdin, TB | 1 |
| Fagan, JD; Ho, BT; Taylor, DL | 1 |
| Baudry, M; Martres, MP; Schwartz, JC | 1 |
| Beani, L; Bianchi, C; Tanganelli, S | 1 |
| Agnati, L; Fuxe, K; Köhler, C; Ogren, SO | 1 |
| Cross, AJ; Longden, A; Owen, F; Poulter, M; Waddington, JL | 2 |
| Creese, I; Snyder, SH; Stewart, K | 1 |
| Leysen, JE | 2 |
| Czlonkowski, A; Herz, A; Höllt, V | 1 |
| Bidzinski, A; Hauptmann, M; Jerlicz, M; Kostowski, W | 1 |
| Laduron, PM; Leysen, JE; Niemegeers, CJ; Tollenaere, JP | 1 |
| Bunney, WE; Pert, A; Pert, CB; Rosenblatt, JE; Sivit, C | 1 |
| Hall, H; Köhler, C; Ogren, SO | 1 |
| Clow, A; Jenner, P; Marsden, CD; Theodorou, A | 5 |
| Angeby, T; Haglund, L; Köhler, C; Ogren, SO | 2 |
| Gardner, EL; Horowitz, SG; Makman, MH; Mishra, RK; Thal, L; Varmuza, S | 1 |
| Mogenson, GJ; Robertson, A; Takigawa, M; Wu, M | 1 |
| Marshall, JF | 1 |
| Kordecka, A; Maj, J; Mogilnicka, E | 1 |
| Klemm, N; Kuhar, MJ; Malouf, AT; Murrin, LC | 1 |
| Fibiger, HC; Lee, T; Nagy, JI; Seeman, P | 1 |
| Farley, IJ; Hornykeiwicz, O; Lee, T; Seeman, P; Tourtellotte, WW | 1 |
| Creese, I; Prosser, T; Synder, SH | 1 |
| Anderson, DJ; Henn, FA; May, K; Titeler, M | 1 |
| Leavens, WJ; Riddall, DR | 1 |
| Henn, F; Seeman, P; Titeler, M | 1 |
| Heffner, TG; Stricker, EM; Zigmond, MJ | 2 |
| Mora, F; Rolls, ET; Sanguinetti, AM; Sweeney, KF | 1 |
| De Boer, T; Florijn, WJ; Tonnaer, JA; Versteeg, DH | 1 |
| Cadet, JL; Zhu, SM | 1 |
| Borrelli, E; Haby, C; Hindelang, C; Lisovoski, F; Revel, MO; Schleef, C; Zwiller, J | 1 |
| Inoue, O; Itoh, T; Suhara, T; Tsukada, H; Yamasaki, T; Yonezawa, H | 1 |
| Aceto, MD; Bowman, ER; Frigeni, V; Harris, LS; Iorio, MA; May, EL | 1 |
| Drucker, GE; Fields, JZ; Gordon, JH; Wichlinski, L | 1 |
| Elazar, Z; Fuchs, S | 1 |
| De Boer, T; Florijn, WJ; Tonnaer, JA; Van Nispen, JW; Versteeg, DH | 1 |
| Grol, CJ; Hacksell, U; Johansson, AM; Nordvall, G | 1 |
| Burke, RE; Reches, A | 1 |
| Ben-Shachar, D; Pinhassi, B; Youdim, MB | 1 |
| Klimek, V; Maj, J; Rogóz, Z; Skuza, G; Sowińska, H | 1 |
| Lu, CL; MacGregor, M; Shaikh, MB; Siegel, A | 1 |
| Matsokis, NA; Panagopoulos, NT; Papadopoulos, GC | 1 |
| Caine, SB; Geyer, MA; Swerdlow, NR | 1 |
| Braff, DL; Geyer, MA; Keith, VA; Swerdlow, NR | 1 |
| Courtney, ND; Howlett, AC; Westfall, TC | 1 |
| Fields, JZ; Gordon, JH | 3 |
| Hashimoto, T; Katsura, M; Kuriyama, K | 1 |
| Bardo, MT; Mattingly, BA; Rowlett, JK | 1 |
| Bouvier, C; Collu, R; Lagacé, G; Potier, M | 1 |
| Bengtsson, S; de Paulis, T; Hall, H; Högberg, T; Johansson, L; Ogren, SO; Ström, P | 1 |
| de Paulis, T; Hall, H; Högberg, T; Johansson, L; Kumar, Y; Ogren, SO | 1 |
| Randall, PK; Severson, JA; Wilcox, RE | 1 |
| Carlsson, A; Fredriksson, K; Grol, CJ; Hacksell, U; Johansson, AM; Sundell, S; Svensson, K | 1 |
| Mandel, RJ; Randall, PK; Yurek, DM | 1 |
| Murray, AM; Waddington, JL | 1 |
| Allen, CN; Bigornia, L; Jan, CR; Lyon, RA; Schneider, AS; Titeler, M | 1 |
| Amdur, RL; Carvey, PM; Kao, LC; Klawans, HL; Lin, DH; Nath, ST; Singh, R; Zhang, TJ | 1 |
| Buck, E; Rommelspacher, H; Wolffgramm, J | 1 |
| Amato, G; Calzà, L; Giardino, L; Piazza, PV | 1 |
| Crocker, AD; Russell, RW | 1 |
| Simmonds, SH; Strange, PG | 1 |
| Heyer, EJ | 1 |
| Jenner, P; Marsden, CD; Rose, S; Weller, ME | 1 |
| Carvalho, AP; Duarte, EP; Oliveira, CR | 1 |
| Bigornia, L; Napp, D; Ryan, KA; Schneider, AS; Suozzo, M | 1 |
| Fuchs, S; Kanety, H | 1 |
| Barros, HT; Dixon, LM; Nobrega, JN; Troncone, LR | 1 |
| Agui, T; Munemura, M; Sibley, DR | 1 |
| Farooqui, T; Harrold, MW; Miller, DD; Uretsky, N; Wallace, LJ; Wallace, RA | 1 |
| Grigoriadis, D; Neumeyer, JL; Ramsby, S; Seeman, P | 1 |
| Barrera, G; Blengio, M; Ferretti, C; Gaietta, G; Genazzani, E; Ghi, P | 1 |
| Chivers, JK; Jenner, P; Marsden, CD; Reavill, C | 2 |
| Iuvone, PM; Zawilska, J | 1 |
| Elazar, Z; Fuchs, S; Siegel, G | 1 |
| Berghoff, W; Coughenour, LL; Courtland, GG; Myers, SL; Pugsley, TA; Shih, YH; Stewart, SF | 1 |
| Cantrill, RC; Kurstjens, NP | 1 |
| George, SR; Seeman, P; Watanabe, M | 2 |
| Hashimoto, T; Koda, H; Kuriyama, K | 1 |
| Giuseppe, A; Laura, C; Luciana, G; Piervincenzo, P | 1 |
| Bartke, A; Doherty, PC; Lane, SJ; Morgan, WW; Pfeil, KA; Smith, MS | 1 |
| Kelly, E; Nahorski, SR; Willcocks, AL | 1 |
| de Vries, JB; Dijkstra, D; Grol, CJ; Horn, AS; Mulder, TB; Wiechers, JW | 1 |
| Fujiwara, M; Nishikawa, H; Taniguchi, T; Yokotani, K | 1 |
| Benelli, A; Bertolini, A; Zanoli, P | 1 |
| Ashkenazi, R; Ben-Shachar, D; Youdim, MB | 1 |
| Allikmets, LKh; Maĭmets, MO; Nurk, AM; Vasar, EE | 1 |
| Arnt, J; Hyttel, J | 1 |
| Apud, JA; Masotto, C; Ongini, E; Racagni, G | 1 |
| Lau, YS; Runice, C | 1 |
| Cassel, G; Persson, SA; Sellström, A | 1 |
| Hall, H; Jerning, E; Sällemark, M | 1 |
| Flauto, C; Groppetti, A; Parati, E; Parenti, M; Vescovi, A | 1 |
| Gerhards, HJ; Henning, R; Lattrell, R; Leven, M | 1 |
| Abou-Gharbia, M; Andree, TH; Moyer, JA; Muth, EA; Patel, UR; Webb, MB | 1 |
| Frigeni, V; Iorio, MA; Reymer, TP | 1 |
| Hong, M; Jenner, P; Kilpatrick, GJ; Marsden, CD | 1 |
| Bajwa, SB; Johnson, RL; Mishra, RK; Srivastava, LK | 1 |
| Bischoff, S; Christen, P; Vassout, A | 1 |
| Dhawan, BN; Gulati, A; Srimal, RC | 1 |
| Kruse, CG; Tulp, MT; van der Heyden, JA; van Wijngaarden, I | 1 |
| Crocker, AD; Faunt, JE | 2 |
| Forler, C; Fozard, JR; Middlemiss, DN; Tricklebank, MD | 1 |
| Markstein, R; Urwyler, S | 1 |
| Finch, CE; Morgan, DG | 1 |
| Fowler, CJ; Köhler, C; Magnusson, O; Ogren, SO | 1 |
| Allikmets, L; Maimets, M; Nurk, A; Soosaar, A; Vasar, E | 1 |
| Creed, GJ; Heydorn, WE; Jacobowitz, DM; Sills, MA; Youdim, MB | 1 |
| Grol, CJ; Hacksell, U; Johansson, AM; Karlén, A; Kenne, L; Sundell, S | 1 |
| Flauto, C; Groppetti, A; Parati, E; Parenti, M; Rusconi, L; Vescovi, A | 1 |
| Amalric, M; Creese, I; Koob, GF; Swerdlow, NR | 1 |
| Andersen, PH; Nielsen, EB | 1 |
| Battaglia, G; Creese, I; Norman, AB | 1 |
| Lin, C; McGonigle, P; Molinoff, PB | 1 |
| Beauregard, G; Bouvier, C; Collu, R; Lafond, J; Lagacé, G; Potier, M | 1 |
| Guan, HC; Seeman, P | 1 |
| Beauclair, L; Csernansky, JG; Lombrozo, L; Mellentin, J | 1 |
| Agui, T; Amlaiky, N; Caron, MG; Kebabian, JW | 1 |
| Jin, GZ; Le, WD; Zhou, XD | 1 |
| Dall'Olio, R; Gandolfi, O; Montanaro, N; Roncada, P | 1 |
| Karlsson-Boethius, G; Köhler, C | 1 |
| Clopton, JK; Gordon, JH | 1 |
| Boyce, S; Davis, A; Fleminger, S; Jenner, P; Kelly, E; Marsden, CD | 1 |
| Martin, JR; Takemori, AE | 3 |
| Cameron, DL; Crocker, AD | 1 |
| Campbell, W; Clark, MS; Mitchell, PJ; Needham, PL; Semple, JM | 1 |
| Spoerlein, MT; VanderWende, C; Wilmot, CA | 1 |
| Hiyama, Y; Sekihara, S; Suda, H; Terasawa, K; Watanabe, H | 1 |
| Crocker, AD; Crocker, JM; Overstreet, DH | 1 |
| Csernansky, JG; Glick, S; Mellentin, J | 1 |
| Wreggett, KA | 1 |
| Thermos, K; Weiss, B; Winkler, JD | 1 |
| Bohmaker, K; Friedhoff, AJ; Goldstein, M; Meller, E; Schweitzer, JW | 1 |
| Grigoriadis, D; Seeman, P | 1 |
| Jenner, P; Marsden, CD; Rupniak, NM | 1 |
| Bédard, PJ; Bouchard, S; Boucher, R; Di Paolo, T; Falardeau, P | 1 |
| Dhawan, BN; Dhawan, KN; Gulati, A; Srimal, RC | 1 |
| Breese, GR; Bunney, BS; Givens, BS; Mailman, RB; Napier, TC; Schulz, DW | 1 |
| Friedhoff, AJ; Rosengarten, H; Schweitzer, JW | 2 |
| Frey, JM; Huffman, RD; Morgan, WW; Ticku, MK | 1 |
| Dorris, RL | 1 |
| Kohjimoto, Y; Kuwaki, T; Nomura, Y; Ono, T; Satoh, H; Shibayama, F; Shirakawa, K | 1 |
| Korf, J; Sebens, JB; Van der Werf, JF | 1 |
| Artalejo, AR; García, AG; González, MC; Hervás, PP; Montiel, C | 1 |
| Brubaker, AN; Colley, M | 1 |
| Beart, PM; de Vries, DJ | 1 |
| Bymaster, FP; Kornfeld, EC; Nichols, CL; Reid, LR; Wong, DT | 1 |
| Cullen, M; Kazmi, SM; Mishra, RK; Rajakumar, G; Ramwani, J; Ross, GM; Srivastava, LK | 1 |
| Brann, MR; Young, WS | 1 |
| Ozaki, L; Stern, N; Tuck, ML | 1 |
| Gredal, O; Nielsen, M | 1 |
| Blengio, M; Bosco, MC; Eva, C; Ferretti, C; Ghi, P; Portaleone, P | 1 |
| Bellush, LL; Joyce, JN; Rowland, N | 1 |
| Arnt, J | 1 |
| Fahn, S; Hassan, M; Jackson-Lewis, V; Traub, M; Wagner, HR | 1 |
| Kikuchi, T; Maeda-Hagiwara, M; Uramoto, H; Watanabe, H | 1 |
| Angeby-Möller, K; de Paulis, T; Hall, H; Johansson, L; Kumar, Y; Ogren, SO; Rämsby, S; Sällemark, M | 1 |
| Davis, AS; Jenner, P; Marsden, CD | 1 |
| Flentge, F; Korf, J; Sebens, JB; van der Werf, JF | 1 |
| Creese, I; Leff, SE | 1 |
| Hsu, LL; Moroi, K | 1 |
| Baldessarini, RJ; Bromley, S; Kula, NS; Neumeyer, JL | 1 |
| Hurd, SM; McClure, WO; Randall, PK; Severson, JA | 1 |
| Bonnet, KA; Csernansky, CA; Csernansky, JG; Hollister, LE | 1 |
| Fleminger, S; Hall, MD; Jenner, P; Kilpatrick, G; Mann, S; Marsden, CD; Rupniak, NM | 2 |
| Aizenstein, ML; Bernardi, MM; De Lucia, R; Scavone, C | 1 |
| Angeby-Möller, K; de Paulis, T; Florvall, L; Hall, H; Johansson, L; Kumar, Y; Ogren, SO; Rämsby, S | 1 |
| Agrawal, AK; Goel, SK; Pandya, KP; Seth, PK | 1 |
| Randall, PK; Yurek, DM | 1 |
| Asano, K; Kadokawa, T; Karasawa, T; Ochi, Y; Oka, M; Terauchi, Y | 1 |
| Fayle, P; Jackson, DM; Jenkins, OF; Lafferty, PA | 1 |
| Hruska, RE | 1 |
| Campbell, IC; Chugani, D; Cohen, RM; Durcan, MJ; Murphy, DL; Pickar, D | 1 |
| Dow, RC; Hill, AG; McQueen, JK | 1 |
| Bhatnagar, R; Cannon, JG; Flynn, J; Ilhan, M; Long, JP | 1 |
| Lee, T; Seeman, P | 1 |
| Asano, T; Goldstein, M; Lew, JY; Ueta, K | 1 |
| List, S; Seeman, P | 1 |
| Snyder, SH | 1 |
| Chiu, S; Mishra, RK; Paulose, CS | 1 |
| Clow, A; Dyer, RG; Jenner, P; Marsden, CD; Murugaiah, K; Theodorou, A | 1 |
| Carino, MA; Horita, A; Lai, HC | 1 |
| Costall, B; Lim, SK; Naylor, RJ | 1 |
| Clow, A; Jenner, P; Mann, S; Marsden, CD; Murugaiah, K; Theodorou, A | 1 |
| Carino, MA; Horita, A; Lai, H | 2 |
| Battaglia, G; Titeler, M | 1 |
| Beart, PM; McDonald, D | 1 |
| Creese, I; Hamblin, MW | 3 |
| Briley, M; Langer, SZ; Lehmann, J | 1 |
| Fleminger, S; Hall, MD; Jenner, P; Kerwin, R; Marsden, CD; Murugaiah, K; Rupniak, NM | 1 |
| Barnett, A; Houser, VP; Iorio, LC; Korduba, CA; Leitz, FH | 1 |
| Fleminger, S; Hall, MD; Jenner, P; Marsden, CD; Rupniak, NM | 1 |
| Ferrer, JM; Mora, F; Sanguinetti, AM; Vives, F | 1 |
| Bourne, RC; Cross, AJ; Gamble, SJ; Waddington, JL | 1 |
| Dyer, R; Fleminger, S; Hong, M; Jenner, P; Mansfield, S; Marsden, CD; Rupniak, N | 1 |
| Bhargava, HN | 4 |
| Baldwin, JJ; Martin, GE; McClure, DE; Watling, KJ; Williams, M | 1 |
| Fuxe, K; Köhler, C; Ogren, SO | 1 |
| Agnati, LF; Celani, MF; Fuxe, K; Martire, M; Zini, I; Zoli, M | 1 |
| Wagner, HN | 1 |
| Achilli, G; Algeri, S; Cimino, M; Lipartiti, M; Perego, C; Ponzio, F; Vantini, G | 1 |
| Eichenberger, E | 1 |
| Dostert, P; Rumigny, JF; Strolin Benedetti, M | 1 |
| Chivers, JK; Hall, MD; Jenner, P; Kelly, E; Marsden, CD | 1 |
| Angeby, K; Florvall, L; Hall, H; Köhler, C; Lindbom, LO; Magnusson, O; Ogren, SO | 1 |
| Finch, CE; Severson, JA | 1 |
| Dvorkin, B; Horowitz, SG; Makman, MH; Thal, LJ | 1 |
| Carlson, KR; Seeger, TF | 1 |
| Hall, MD; Jenner, P; Marsden, CD | 2 |
| Allen, RM | 1 |
| Kuno, T; Tanaka, C | 1 |
| de Mello, FG; Klein, WL; Ventura, AL | 1 |
| Marshall, JF; Neve, KA | 1 |
| Agid, Y; Bokobza, B; Javoy-Agid, F; Montfort, JC; Ruberg, M | 1 |
| MacKenzie, RG; Zigmond, MJ | 1 |
| Curtin, J; Fields, J; Koller, W | 1 |
| Iwamoto, ET | 1 |
| Agrawal, AK; Bondy, SC; Seth, PK; Squibb, RE; Tilson, HA; Uphouse, LL | 1 |
| Gershon, S; Lautin, A; Rotrosen, J; Stanley, M; Wazer, D | 1 |
| Drew, MC; Marshall, JF; Neve, KA | 1 |
| Markstein, R | 1 |
| Cote, TE; Frey, EA; Grewe, CW; Kebabian, JW | 2 |
| Anene, C; Dowd, FJ; Lau, YS; Runice, C | 1 |
| Agnati, LF; Celani, MF; Fuxe, K | 1 |
| Anthopoulou, H; Covelli, V; Lucchi, L; Spano, PF; Trabucchi, M | 1 |
| Bloom, FE; Magistretti, PJ; Shoemaker, WJ; Staunton, DA | 1 |
| Bloom, FE; Deyo, SN; Magistretti, PJ; Shoemaker, WJ; Staunton, DA | 1 |
| Dowd, F; Lau, YS; Runice, C | 1 |
| Berry-Kravis, E; Dawson, G; Freedman, SB | 1 |
| Lahaye, D; Markstein, R | 1 |
| Bonnet, KA; Csernansky, JG; Grabowsky, K; Hollister, LE; Holman, CA; King, R | 1 |
| Schallert, T; Upchurch, M; Vaughn, DM; Wilcox, RE | 1 |
| Creese, I; Leff, S; Sibley, DR | 1 |
| Randall, PK; Severson, JA | 1 |
| Hall, MD; Jenner, P; Kelly, E; Marsden, CD | 1 |
| Fibiger, HC; Jakubovic, A; Pittman, KJ | 1 |
| Clineschmidt, BV; Jones, JH; Martin, GE; Pettibone, DJ; Williams, M; Yarbrough, GG | 1 |
| Lee, EK; Tamminga, CA; Walters, JR; Waszczak, BL | 1 |
| Hall, MD; Jenner, P; Kilpatrick, G; Marsden, CD; Rupniak, NM | 1 |
| Coppings, RJ; Giachetti, A; Krulich, L; Mayfield, MA; McCann, SM | 1 |
| Battaini, F; Govoni, S; Rius, RA; Spano, PF; Trabucchi, M | 1 |
| Bohmaker, K; Friedhoff, AJ; Meller, E | 1 |
| Bédard, PJ; Boucher, R; Daigle, M; Di Paolo, T | 1 |
| Bédard, P; Deshaies, P; Di Paolo, T; Falardeau, P | 1 |
| Diamond, BI; Gordon, JH | 1 |
| Fleminger, S; Hall, MD; Jenner, P; Marsden, CD; Murugaiah, K; Theodorou, A | 1 |
| Matvienko, OA; Nurk, AM; Zharkovskiĭ, AM | 1 |
| Crider, AM; Fahn, S; Hassan, MN; Hemdi, TF | 1 |
| Bakunzi, FR; Eyre, P | 1 |
| Cannon-Spoor, HE; Freed, WJ; Hoffer, BJ; Ko, GN; Kuhar, MJ; Morihisa, JM; Niehoff, DL; Olson, L; Wyatt, RJ | 1 |
| Oelssner, W; Raubach, KH | 1 |
| Caron, MG; Kilpatrick, BF; Sibley, DR | 1 |
| Benson, DI; Kuhn, CM; Meyerson, LR; Stanley, M; Virgilio, J; Wazer, D | 1 |
| Beaumont, K; Breese, GR; Davis, SD; Frye, GD; Hernandez, DE; Kilts, CA; Luttinger, D; Mailman, RB; Mason, GA; Nemeroff, CB; Prange, AJ; Widerlöv, E | 1 |
| Dewey, KJ; Fibiger, HC | 1 |
| Fleminger, S; Jenner, P; Marsden, CD; Murugaiah, K; Theodorou, A | 1 |
| Bartus, RT; Beer, B; Clody, D; Finch, C; Joseph, JA; Morgan, D; Sesack, S | 1 |
| Gudelsky, GA; Meltzer, HY; Mikuni, M; Simonovic, M | 1 |
| Fuller, RW; Hemrick-Luecke, SK; Snoddy, HD | 1 |
| Hruska, RE; Silbergeld, EK; Weir, RL | 1 |
| Koc, BA; Marley, E | 1 |
| Gardner, EL; Seeger, TF; Thal, L | 1 |
| Riffee, WH; Smith, RV; Vaughn, DM; Wilcox, RE | 1 |
| Haubrich, DR; Martin, GE; Williams, M | 1 |
| Bannet, J; Belmaker, RH; Globus, M; Lerer, B | 1 |
| Creese, I; Sibley, DR | 3 |
| Creese, I; Mahan, LC; Sibley, DR | 1 |
| Mason, WT | 1 |
| Codd, EE; Scholtens, H; Van Ree, JM; Verhoef, JC; Witter, A; Wolterink, G | 1 |
| Agnati, LF; Fuxe, K; Goldstein, M; Köhler, C; Lew, JY; Okada, K | 1 |
| Buczko, W; De Blasi, A | 1 |
| Roy, EJ; Sheinkop, S; Wilson, MA | 1 |
| Creese, I; Segal, DS; Sibley, DR; Weinberger, S | 1 |
| Curell, J; Hitzemann, R; Hom, D; Loh, H | 1 |
| Holmgren, B; Urbá-Holmgren, R | 1 |
| Caron, MG; De Lean, A; Kilpatrick, BF | 3 |
| Zapata, P; Zuazo, A | 1 |
| Holden, WL; Katerinopoulos, HE; Libes, RB; Murphy, RB; Narula, AP; Schuster, DI | 1 |
| Mahler, HR; Near, JA | 2 |
| Mogenson, GJ; Wu, M | 1 |
| Achilli, G; Algeri, S; Cimino, M; Perego, C; Ponzio, F; Vantini, G | 1 |
| Totaro, JA; Williams, M | 1 |
| Anderson, JA; Riffee, WH; Smith, RV; Wilcox, RE | 1 |
| Hruska, RE; Silbergeld, EK | 2 |
| Allen, RM; Brauchi, JT; Lane, JD | 1 |
| Meltzer, HY; Simonovic, M | 1 |
| Diamond, BI; Fields, JZ; Gordon, JH; Perry, KO | 1 |
| Finch, CE; Randall, PK; Severson, JA | 1 |
| Baldessarini, RJ; Campbell, A; Madsen, JR | 1 |
| Carino, MA; Horita, A; Kazi, MS; Lai, H | 1 |
| De Ryck, M; Hruska, RE; Ludmer, LM; Pitman, KT; Silbergeld, EK | 1 |
| Fields, JZ; Lee, JM; Ritzmann, RF | 1 |
| Bischoff, S; Bittiger, H; Delini-Stula, A; Ortmann, R | 1 |
| Adams, L; Creese, I; Hyttel, J; Leff, S | 1 |
| Groves, PM; Molinoff, PB; Staunton, DA; Wolfe, BB | 1 |
| Brown, GM; Seeman, P; Titeler, M; Van Loon, GR | 1 |
| Arana, GW; Baldessarini, RJ; Kula, NS; Lamont, JS; Law, SJ; Neumeyer, JL | 1 |
| Hanbauer, I; Memo, M; Pradhan, S | 1 |
| Oades, RD | 1 |
| Clincke, G; Fransen, J; Wauquier, A | 1 |
| Smythies, JR | 1 |
| Stevens, JR | 1 |
| Argiolas, A; Collu, R; Devoto, P; Marchisio, AM; Stefanini, E; Vernaleone, F | 1 |
| Creese, I; Hamblin, M | 1 |
| Kayaalp, SO; Neff, NH | 1 |
| Seeman, P; Weinreich, P | 1 |
| Gershon, S; Lautin, A; Rotorsen, J; Stanley, M; Wazer, D | 1 |
| Gommeren, W; Leysen, JE | 1 |
| Senogles, SE | 1 |
| Guilarte, TR; May, CH; Vesper, J; Vogel, S; Wagner, HN; Woiciechowsky, C | 1 |
| Hirose, T; Kikuchi, T; Miwa, T; Morita, S; Oshiro, Y; Tottori, K; Uwahodo, Y | 1 |
| Consolo, S; Costi, P; Kleinrok, Z; Kolasa, K; Zecca, L | 1 |
| Bhatia, M; Borrelli, E; Ceraline, J; Guiramand, J; Montmayeur, JP | 1 |
| Bruhwyler, J; Damas, J; Delarge, J; Geczy, J; Liégeois, JF; Masereel, B; Rogister, F | 1 |
| Ekman, A; Eriksson, E; Heilig, M; Nissbrandt, H | 1 |
| Contestabile, A; Dall'Olio, R; Facchinetti, F; Gandolfi, O | 1 |
| Grol, CJ; Hacksell, U; Johansson, AM; Karlén, A | 1 |
| Di Paolo, T; Lévesque, D | 1 |
| Burnham, P; Louis, JC; Magal, E; Varon, S | 1 |
| Korf, J; Vaalburg, W; van der Worp, H; Visser, GM; Wiegman, T; Zijlstra, S | 1 |
| Albin, RL; Becker, JB; Curran, EJ | 1 |
| DeSouza, EB; Grigoriadis, DE; Levant, B | 1 |
| Absil, P; Balthazart, J; Das, S | 1 |
| Carlsson, A; Haadsma-Svensson, SR; Smith, MW; Svensson, K; Waters, N | 1 |
| Allard, S; Falardeau, P; Lapointe, S | 1 |
| Farooqui, T; Markovich, K; Miller, D; Uretsky, N; Wallace, L | 1 |
| Bregna, DE; Burgher, KL; Corbett, R; Hartman, HB; Hrib, NJ; Jurcak, JG; Kafka, S; Kerman, LL; Kongsamut, S; Roehr, JE; Szewczak, MR; Woods-Kettelberger, AT | 1 |
| Grünewald, S; Michel, H; Reiländer, H | 1 |
| Kreutz, MR; Sabel, BA; Schroeder, H; Schroeder, U | 1 |
| Andersson, K; Bjelke, B; Chen, Y; Gross, J; Herrera-Marschitz, M; Hillefors-Berglund, M; von Euler, G | 1 |
| Chen, LJ; Creese, I; Dong, ZJ; Jin, GZ | 1 |
| Creese, I; Tepper, JM | 1 |
| Govitrapong, P; Phivthongngam, L; Sanvarinda, Y | 1 |
| Brust, P; Gupta, CN; Parimoo, P; Raghavan, SA; Rangisetty, JB; Sridhar, N; Srinivas, P; Subramanian, AR; Veeranjaneyulu, A | 1 |
| Geurts, M; Hermans, E; Maloteaux, JM | 1 |
| Armogida, M; Chiacchio, S; Colzi, A; Corsini, GU; DeMontis, MG; Maggio, R; Scarselli, M | 1 |
| Baik, JH; Borrelli, E; Dierich, A; LeMeur, M; Piazza, PV; Picetti, R; Rougé-Pont, F; Usiello, A | 1 |
| Fu, D; Javitch, JA; Lin, H; Strange, PG; Wilson, J | 1 |
| de Moes, J; Feenstra, RW; Hofma, JJ; Kling, H; Kruse, CG; Kuipers, W; Long, SK; Tulp, MT; van der Heyden, JA | 1 |
| Chen, R; Guo, J; Xiao, L | 1 |
| Bordeleau, M; Brooks, KM; Corbett, TJ; de Lannoy, I; Hendrix, JA; Kafka, S; Kamboj, RK; Kapples, KJ; Laws-Ricker, L; Lee, DK; Owolabi, J; Palermo, MG; Rizkalla, G; Shimshock, SJ; Shutske, GM; Tomer, JD; Vargas, HM | 1 |
| Guo, H; Jin, G; Tang, Z; Xu, L; Yu, Y; Zhou, J | 1 |
| Abramov, U; Bourin, M; Kõks, S; Matsui, T; Vasar, E; Veraksits, A | 1 |
| Nickolls, SA; Strange, PG | 1 |
| Gazi, L; Lopéz-Giménez, JF; Pauwels, PJ; Strange, PG; Wurch, T | 1 |
| Bjartmar, C; Trapp, BD | 1 |
| Lin, H; Roberts, DJ; Strange, PG | 1 |
| Fu, Y; Jin, GZ; Zhu, XZ; Zhu, ZT | 1 |
| Childers, SR; Davies, HM; Gregg, TC; O'Connor, KA | 1 |
| Kost, NV; Meshavkin, VK; Myasoedov, NF; Sokolov, OY; Zolotarev, YA; Zozulya, AA | 1 |
| Coffeen, U; del Angel, R; López-Avila, A; López-Muñoz, FJ; Ortega-Legaspi, JM; Pellicer, F | 1 |
| Michaelides, M; Piyis, YK; Thanos, PK; Volkow, ND; Wang, GJ | 1 |
| Cho, EY; Kim, JH; Kim, KM; Min, C; Park, JH | 1 |
| Halldin, C; Hong, J; Innis, RB; Liow, JS; Pike, VW; Seneca, N; Sibley, DR; Skinbjerg, M; Weinshenker, D | 1 |
4 review(s) available for apomorphine and spiperone
| Article | Year |
|---|---|
Neuroleptic/dopamine receptors: elevation and reversal.
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Humans; Receptors, Dopamine; Receptors, Drug; Spiperone; Stereotyped Behavior | 1980 |
Role of amantadine in the management of neuroleptic-induced extrapyramidal syndromes: overview and pharmacology.
Topics: Amantadine; Animals; Antipsychotic Agents; Apomorphine; Basal Ganglia Diseases; Binding, Competitive; Butaclamol; Humans; Kinetics; Spiperone | 1983 |
Classification of dopamine receptors.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Butyrophenones; Dopamine; Hydroxydopamines; In Vitro Techniques; Membranes, Artificial; Oxidopamine; Receptors, Dopamine; Spiperone | 1983 |
Radioreceptor labeling of pre- and postsynaptic dopamine receptors.
Topics: Animals; Apomorphine; Binding Sites; Haloperidol; Humans; Parkinson Disease; Radioligand Assay; Receptors, Dopamine; Spiperone; Synapses | 1980 |
403 other study(ies) available for apomorphine and spiperone
| Article | Year |
|---|---|
Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding, Competitive; Blotting, Northern; Brain; Cell Line; Cell Membrane; Cloning, Molecular; Dopamine; Humans; Kinetics; Molecular Sequence Data; Molecular Weight; Oligonucleotide Probes; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D5; RNA, Messenger; Sequence Homology, Nucleic Acid; Transfection | 1991 |
Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics.
Topics: Amino Acid Sequence; Animals; Antipsychotic Agents; Base Sequence; Brain Chemistry; Cell Line; Cloning, Molecular; Cricetinae; DNA; DNA Restriction Enzymes; Dopamine; Guanylyl Imidodiphosphate; Molecular Sequence Data; Nucleic Acid Hybridization; Polymerase Chain Reaction; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; RNA, Messenger; Sequence Homology, Nucleic Acid; Tissue Distribution | 1990 |
(+/-)-7-chloro-8-hydroxy-1-(4'-[125I]iodophenyl)-3-methyl-2,3,4,5- tetrahydro-1H-3-benzazepine: a potential CNS D-1 dopamine receptor imaging agent.
Topics: Animals; Benzazepines; Brain; Chemical Phenomena; Chemistry; Humans; Iodobenzoates; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Tissue Distribution | 1989 |
5-HT1A-receptor antagonism: N-alkyl derivatives of (R)-(-)-8,11-dimethoxynoraporphine.
Topics: Animals; Aporphines; Behavior, Animal; Cats; Chemical Phenomena; Chemistry; Dopamine Agents; Hemodynamics; In Vitro Techniques; Rats; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Serotonin; Stereoisomerism | 1989 |
Functional group contributions to drug-receptor interactions.
Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship | 1984 |
Synthesis and pharmacological investigation of novel 2-aminothiazole-privileged aporphines.
Topics: Animals; Antiparkinson Agents; Aporphines; Humans; Protein Binding; Rats; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine D1; Receptors, Dopamine D2; Serotonin 5-HT1 Receptor Agonists; Structure-Activity Relationship; Thiazoles | 2008 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Effects of neuroleptics on release of 3H-dopamine from slices of rat corpus striatum.
Topics: Animals; Antipsychotic Agents; Apomorphine; Chlorpromazine; Cocaine; Corpus Striatum; Dopamine; Electric Stimulation; Fluphenazine; Haloperidol; Male; Rats; Spiperone | 1977 |
Neuroleptic binding and their effects on the spontaneous and potassium-evoked release of 3H-dopamine from the striatum and of 3H-noradrenaline from the cerebral cortex.
Topics: Animals; Antipsychotic Agents; Apomorphine; Cerebral Cortex; Corpus Striatum; Dopamine; In Vitro Techniques; Male; Norepinephrine; Potassium; Rats; Spiperone | 1978 |
Neuroleptic receptors: stereoselectivity for neuroleptic enantiomers.
Topics: Animals; Antipsychotic Agents; Apomorphine; Binding Sites; Butaclamol; Cattle; Caudate Nucleus; Cyproheptadine; Dibenzocycloheptenes; Dibenzothiepins; Isomerism; Isoquinolines; Receptors, Drug; Spiperone; Stereoisomerism | 1979 |
Nigrostriatal lesions enhance striatal 3H-apomorphine and 3H-spiroperidol binding.
Topics: Animals; Apomorphine; Butyrophenones; Corpus Striatum; Hydroxydopamines; Rats; Receptors, Dopamine; Spiperone; Substantia Nigra; Tyrosine 3-Monooxygenase | 1979 |
Intracranial self-stimulation in orbitofrontal cortex and caudate nucleus of rhesus monkey: effects of apomorphine, pimozide, and spiroperidol.
Topics: Animals; Apomorphine; Butyrophenones; Caudate Nucleus; Cerebral Cortex; Drug Interactions; Haplorhini; Macaca mulatta; Pimozide; Self Stimulation; Spiperone | 1979 |
Effects of estrogens on the characteristics of [3H]spiroperidol and [3H]RU24213 binding in rat anterior pituitary gland and brain.
Topics: Animals; Apomorphine; Binding, Competitive; Brain; Butyrophenones; Castration; Clonidine; Dihydroergotoxine; Estradiol; Female; Phenethylamines; Phentolamine; Pituitary Gland, Anterior; Rats; Receptors, Dopamine; Spiperone | 1979 |
Brain dopamine receptors and sleep in the rat: effects of stimulation and blockade.
Topics: Animals; Apomorphine; Brain; Chlorpromazine; Dopamine; Electroencephalography; Electromyography; Male; Rats; Receptors, Drug; Sleep; Sleep, REM; Spiperone; Time Factors | 1976 |
On the role of the central noradrenergic and dopaminergic systems in the regulation of TSH secretion in the rat.
Topics: Animals; Apomorphine; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Clonidine; Ditiocarb; Dopamine; Kinetics; Male; Methyltyrosines; Norepinephrine; Phenoxybenzamine; Phentolamine; Pituitary Gland; Propranolol; Rats; Spiperone; Stress, Physiological; Thyrotropin; Thyrotropin-Releasing Hormone | 1977 |
Selective labeling of apomorphine receptors by 3H-LSD.
Topics: Animals; Apomorphine; Cattle; Caudate Nucleus; Lysergic Acid Diethylamide; Phentolamine; Receptors, Dopamine; Receptors, Opioid; Serotonin; Spiperone; Tritium | 1979 |
Multiple dopamine binding sites: subcellular localization and biochemical characterization.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Binding, Competitive; Caudate Nucleus; Haloperidol; Kinetics; Male; Rats; Receptors, Dopamine; Spiperone; Subcellular Fractions | 1979 |
Guanine nucleotides distinguish between two dopamine receptors.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Corpus Striatum; Dopamine; Guanosine Triphosphate; Kainic Acid; Kinetics; Rats; Receptors, Dopamine; Spiperone | 1979 |
Similar binding of 3H-ADTN and 3H-apomorphine to calf brain dopamine receptors.
Topics: Animals; Apomorphine; Brain; Cattle; Caudate Nucleus; Corpus Striatum; In Vitro Techniques; Naphthalenes; Receptors, Dopamine; Spiperone; Tetrahydronaphthalenes | 1979 |
Dopamine agonists reverse the elevated 3H-neuroleptic binding in neuroleptic-pretreated rats.
Topics: Animals; Apomorphine; Bromocriptine; Carbidopa; Corpus Striatum; Dyskinesia, Drug-Induced; Haloperidol; Levodopa; Male; Radioligand Assay; Rats; Receptors, Dopamine; Receptors, Drug; Spiperone | 1979 |
Selective labelling of different dopamine receptors by a new agonist 3H-ligand: 3H-N-propylnorapomorphine.
Topics: Animals; Apomorphine; Cattle; Caudate Nucleus; Radioligand Assay; Receptors, Dopamine; Spiperone | 1979 |
Dopamine receptor binding regulated by guanine nucleotides.
Topics: Animals; Apomorphine; Corpus Striatum; Guanine Nucleotides; In Vitro Techniques; Ions; Naphthols; Rats; Receptors, Dopamine; Spiperone; Tetrahydronaphthalenes | 1979 |
Increased dopamine receptor binding in rat brain by repeated cocaine injections.
Topics: Animals; Apomorphine; Butyrophenones; Cocaine; Dose-Response Relationship, Drug; Male; Motor Activity; Rats; Receptors, Dopamine; Spiperone | 1979 |
3H-Domperidone: a selective ligand for dopamine receptors.
Topics: Animals; Apomorphine; Benzimidazoles; Corpus Striatum; Dopamine Antagonists; In Vitro Techniques; Kinetics; Ligands; Male; Membranes; Mice; Piperidines; Receptors, Dopamine; Spiperone; Time Factors | 1979 |
Dopamine modulation of acetylcholine release from the guinea-pig brain.
Topics: Acetylcholine; Animals; Apomorphine; Brain; Catecholamines; Dopamine; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Spiperone | 1979 |
Evidence for in vivo binding of apomorphine and bromocriptine to receptor sites not labelled by 3H-spiperone.
Topics: Animals; Apomorphine; Binding Sites; Binding, Competitive; Brain; Bromocriptine; Butyrophenones; In Vitro Techniques; Male; Rats; Spiperone | 1979 |
Functional distinction between DA-stimulated adenylate cyclase and 3H-spiperone binding sites in rat striatum.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Behavior, Animal; Binding Sites; Butyrophenones; Corpus Striatum; Dopamine; Hydroxydopamines; In Vitro Techniques; Male; Rats; Receptors, Dopamine; Spiperone | 1979 |
Species variation in dopamine receptor binding.
Topics: Animals; Apomorphine; Binding, Competitive; Brain; Cattle; Caudate Nucleus; Fluphenazine; Haloperidol; Humans; In Vitro Techniques; Male; Rats; Receptors, Dopamine; Species Specificity; Spiperone; Tetrahydronaphthalenes | 1979 |
Unitary dopaminergic receptor composed of cooperatively linked agonist and antagonist sub-unit binding sites.
Topics: Animals; Apomorphine; Binding Sites; Corpus Striatum; Female; Haloperidol; Hydroxydopamines; Kainic Acid; Kinetics; Rats; Receptors, Dopamine; Spiperone; Subcellular Fractions | 1979 |
The demonstration in vivo of specific binding sites for neuroleptic drugs in mouse brain.
Topics: Animals; Apomorphine; Brain; Catalepsy; Chlorpromazine; Dibenzocycloheptenes; Dopamine; Haloperidol; Humans; Male; Mice; Piribedil; Quinolizines; Receptors, Dopamine; Receptors, Drug; Spiperone; Structure-Activity Relationship; Tranquilizing Agents | 1977 |
Behavioral effects of neuroleptics, apomorphine and amphetamine after bilateral lesion of the locus coeruleus in rats.
Topics: Animals; Apomorphine; Behavior; Biogenic Amines; Brain Chemistry; Butyrophenones; Dextroamphetamine; Haloperidol; Humans; Locus Coeruleus; Male; Motor Activity; Rats; Spiperone; Stereotyped Behavior; Time Factors | 1977 |
Serotonergic component of neuroleptic receptors.
Topics: Animals; Apomorphine; Binding, Competitive; Corpus Striatum; Frontal Lobe; Haloperidol; Humans; In Vitro Techniques; Lysergic Acid Diethylamide; Rats; Receptors, Dopamine; Receptors, Serotonin; Seizures; Spiperone; Stereotyped Behavior; Tranquilizing Agents; Tryptamines | 1978 |
Long-term treatment with lithium prevents the development of dopamine receptor supersensitivity.
Topics: Animals; Apomorphine; Corpus Striatum; Haloperidol; Humans; Lithium; Male; Rats; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Time Factors | 1978 |
Studies on the stereoselective dopamine receptor blockade in the rat brain by rigid spiro amines.
Topics: Animals; Apomorphine; Binding, Competitive; Brain; Humans; Motor Activity; Rats; Receptors, Dopamine; Spiperone; Spiro Compounds; Stereoisomerism; Stereotyped Behavior | 1978 |
Striatal dopamine receptors become supersensitive while rats are geven trifluoperazine for six months.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adenylyl Cyclases; Animals; Apomorphine; Corpus Striatum; Dopamine; Homovanillic Acid; Humans; Male; Rats; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Time Factors; Trifluoperazine | 1979 |
Regional displacement by sulpiride of [3H]spiperone binding in vivo. Biochemical and behavioural evidence for a preferential action of limbic and nigral dopamine receptors.
Topics: Animals; Apomorphine; Binding, Competitive; Brain; Butyrophenones; Catalepsy; Haloperidol; Humans; Male; Rats; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Sulpiride | 1979 |
Dopamine antagonist binding increases in two behaviorally distinct striatal denervation syndromes.
Topics: Animals; Apomorphine; Behavior; Butyrophenones; Corpus Striatum; Denervation; Haloperidol; Humans; Hydroxydopamines; Male; Neural Pathways; Rats; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Substantia Nigra | 1979 |
Self-stimulation of the nucleus accumbens and ventral tegmental area of Tsai attenuated by microinjections of spiroperidol into the nucleus accumbens.
Topics: Animals; Apomorphine; Butyrophenones; Evoked Potentials; Frontal Lobe; Humans; Male; Neural Pathways; Neurons; Nucleus Accumbens; Rats; Receptors, Dopamine; Self Stimulation; Septal Nuclei; Spiperone; Stereotyped Behavior; Tegmentum Mesencephali | 1979 |
Apomorphine-induced rotation in the unilateral 6-OHDA-lesioned rat: relationship to changes in striatal adenylate cyclase activity and 3H-spiperone binding.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Behavior; Butyrophenones; Corpus Striatum; Humans; Hydroxydopamines; Male; Rats; Spiperone; Stereotyped Behavior | 1979 |
Somatosensory inattention after dopamine-depleting intracerebral 6-OHDA injections: spontaneous recovery and pharmacological control.
Topics: Animals; Apomorphine; Attention; Brain; Dopamine; Functional Laterality; Humans; Hydroxydopamines; Male; Mechanoreceptors; Methyltyrosines; Norepinephrine; Orientation; Rats; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Tegmentum Mesencephali; Touch | 1979 |
Chronic treatment with antidepressant drugs: potentiation of apomorphine-induced aggressive behaviour in rats.
Topics: Aggression; Animals; Antidepressive Agents; Apomorphine; Behavior; Drug Interactions; Humans; Male; Metergoline; Phenoxybenzamine; Phentolamine; Rats; Spiperone; Stereotyped Behavior; Time Factors | 1979 |
Dopamine receptor binding in vivo: the feasibility of autoradiographic studies.
Topics: Animals; Apomorphine; Autoradiography; Butaclamol; Cerebellum; Cerebral Cortex; Corpus Striatum; Haloperidol; Hippocampus; Male; Rats; Receptors, Dopamine; Spiperone | 1978 |
Direct evidence for presynaptic and postsynaptic dopamine receptors in brain.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Brain; Caudate Nucleus; Haloperidol; Hydroxydopamines; Male; Putamen; Rats; Receptors, Dopamine; Spiperone; Substantia Nigra; Synaptic Membranes | 1978 |
Binding of 3H-neuroleptics and 3H-apomorphine in schizophrenic brains.
Topics: Adult; Aged; Apomorphine; Brain; Butyrophenones; Caudate Nucleus; Cerebral Cortex; Female; Haloperidol; Humans; Male; Middle Aged; Nucleus Accumbens; Putamen; Schizophrenia; Spiperone; Tranquilizing Agents | 1978 |
Dopamine receptor binding: specificity, localization and regulation by ions and guanyl nucleotides.
Topics: Animals; Apomorphine; Brain; Cations; Cattle; Corpus Striatum; Guanine Nucleotides; In Vitro Techniques; Organ Specificity; Rats; Receptors, Dopamine; Receptors, Serotonin; Species Specificity; Spiperone; Tetrahydronaphthalenes | 1978 |
Investigations concerning the cellular origin of dopamine receptors.
Topics: Animals; Apomorphine; Astrocytes; Autoradiography; Brain; Cattle; Caudate Nucleus; In Vitro Techniques; Rats; Receptors, Dopamine; Spiperone; Substantia Nigra; Synaptosomes | 1978 |
Affinities of drugs for the agonist and antagonist states of the dopamine receptor.
Topics: Animals; Apomorphine; Binding, Competitive; Cattle; Caudate Nucleus; In Vitro Techniques; Membranes; Receptors, Dopamine; Spiperone | 1978 |
Differential centrifugation of 3H-apomorphine and 3H-spiroperidol binding sites.
Topics: Animals; Apomorphine; Butyrophenones; Cattle; Caudate Nucleus; Centrifugation; In Vitro Techniques; Receptors, Drug; Spiperone | 1978 |
Antiparkinsonian drug doses and neuroleptic receptors.
Topics: Animals; Antiparkinson Agents; Apomorphine; Bromocriptine; Cattle; Caudate Nucleus; Haloperidol; In Vitro Techniques; Receptors, Dopamine; Spiperone; Tritium | 1978 |
Effects of dopaminergic agonists and antagonists of feeding in intact and 6-hydroxydopamine-treated rats.
Topics: Animals; Apomorphine; Benztropine; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Brain; Catecholamines; Cocaine; Dextroamphetamine; Dopamine; Dopamine Antagonists; Eating; Hydroxydopamines; Levodopa; Male; Methylphenidate; Methyltyrosines; Motor Activity; Rats; Spiperone; Telencephalon | 1977 |
Spontaneous firing rate of neurones in the prefrontal cortex of the rat: evidence for a dopaminergic inhibition.
Topics: Action Potentials; Animals; Apomorphine; Cerebral Cortex; Dextroamphetamine; Dopamine; Dose-Response Relationship, Drug; Frontal Lobe; Levodopa; Male; Neural Inhibition; Neurons; Rats; Receptors, Dopamine; Spiperone | 1976 |
Characterization of the inhibitory effect of adrenocorticotropin/melanocyte-stimulating hormone-like peptides on the binding of dopamine receptor ligands to the dopamine D2 receptor in vitro.
Topics: Adrenocorticotropic Hormone; Age Factors; Animals; Apomorphine; Binding, Competitive; Dopamine D2 Receptor Antagonists; Guanylyl Imidodiphosphate; Ligands; Male; Melanocyte-Stimulating Hormones; Peptides; Rats; Rats, Wistar; Receptors, Dopamine D2; Spiperone; Temperature; Time Factors | 1992 |
The intrastriatal 6-hydroxydopamine model of hemiparkinsonism: quantitative receptor autoradiographic evidence of correlation between circling behavior and presynaptic as well as postsynaptic nigrostriatal markers in the rat.
Topics: Amphetamine; Animals; Apomorphine; Autoradiography; Biomarkers; Corpus Striatum; Immunohistochemistry; Injections; Male; Mazindol; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Substantia Nigra; Synapses | 1992 |
Induction of D2 dopamine receptor mRNA synthesis in a 6-hydroxydopamine parkinsonian rat model.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Blotting, Northern; Corpus Striatum; Dopamine; Female; Homovanillic Acid; Neurons, Efferent; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; RNA, Messenger; Spiperone; Stereotyped Behavior; Substantia Nigra | 1992 |
Effect of lithium and anesthetics on in vivo binding of dopamine receptors.
Topics: Animals; Apomorphine; Benzazepines; Ketamine; Lithium; Male; Mice; Mice, Inbred C3H; Pentobarbital; Rats; Receptors, Dopamine; Spiperone | 1991 |
Common stereospecificity of opioid and dopamine systems for N-butyrophenone prodine-like compounds.
Topics: Alphaprodine; Analgesia; Analgesics; Animals; Antipsychotic Agents; Apomorphine; Binding, Competitive; Brain; Dihydromorphine; Indicators and Reagents; Isomerism; Male; Mice; Molecular Structure; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Opioid; Receptors, Opioid, mu; Spiperone; Stereotyped Behavior; Structure-Activity Relationship | 1991 |
Neurochemical basis for the absence of overt "stereotyped" behaviors in rats with up-regulated striatal D2 dopamine receptors.
Topics: Animals; Antipsychotic Agents; Apomorphine; Corpus Striatum; Dyskinesia, Drug-Induced; Kinetics; Rats; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Stereotyped Behavior; Tyrosine 3-Monooxygenase; Up-Regulation | 1991 |
Vanadate inhibits agonist binding to D2 dopamine receptor.
Topics: Animals; Apomorphine; Binding, Competitive; Cattle; Cell Membrane; Corpus Striatum; Dopamine Agents; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Kinetics; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Vanadates | 1991 |
ACTH/MSH-like peptides inhibit the binding of dopaminergic ligands to the dopamine D2 receptor in vitro.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenocorticotropic Hormone; Amino Acid Sequence; Animals; Apomorphine; Cosyntropin; Dopamine Agents; In Vitro Techniques; Kinetics; Ligands; Male; Melanocyte-Stimulating Hormones; Molecular Sequence Data; Peptide Fragments; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Structure-Activity Relationship; Tetrahydronaphthalenes | 1991 |
5-Oxygenated N-alkyl- and N,N-Dialkyl-2-amino-1-methyltetralins. Effects of structure and stereochemistry on dopamine-D2-receptor affinity.
Topics: Animals; Apomorphine; Binding, Competitive; Cattle; Computer Simulation; Corpus Striatum; Culture Techniques; Dopamine Agents; Oxygen; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Stereoisomerism; Structure-Activity Relationship; Tetrahydronaphthalenes; Tritium | 1991 |
Preserved striatal tyrosine hydroxylase activity, assessed in vivo, following neonatal hypoxia-ischemia.
Topics: Animals; Animals, Newborn; Apomorphine; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; Benzazepines; Brain Ischemia; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Female; Hydrazines; Hypoxia; Kinetics; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Spiperone; Tyrosine 3-Monooxygenase | 1991 |
Prevention of neuroleptic-induced dopamine D2 receptor supersensitivity by chronic iron salt treatment.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antipsychotic Agents; Apomorphine; Brain Chemistry; Chlorpromazine; Chromatography, High Pressure Liquid; Dopamine; Ferrous Compounds; Free Radicals; Hemoglobins; Homovanillic Acid; In Vitro Techniques; Iron; Liver; Male; Nerve Degeneration; Prolactin; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone | 1991 |
The effect of (+)- and (-)-oxaprotiline administered repeatedly on the dopamine system.
Topics: Animals; Antidepressive Agents; Apomorphine; Benzazepines; Dextroamphetamine; Exploratory Behavior; Male; Maprotiline; Motor Activity; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereoisomerism; Stereotyped Behavior; Swimming | 1991 |
Dopaminergic regulation of quiet biting attack behavior in the cat.
Topics: Aggression; Analysis of Variance; Animals; Apomorphine; Benzazepines; Cats; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Female; Hypothalamic Area, Lateral; Male; Spiperone; Time Factors | 1991 |
Dopaminergic innervation and binding in the rat cerebellum.
Topics: Afferent Pathways; Animals; Apomorphine; Cerebellum; Dopamine; Female; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1991 |
Carbachol infusion into the dentate gyrus disrupts sensorimotor gating of startle in the rat.
Topics: Acoustic Stimulation; Animals; Apomorphine; Carbachol; Cerebral Cortex; Dose-Response Relationship, Drug; Hippocampus; Injections; Male; Physical Stimulation; Rats; Rats, Inbred Strains; Reflex, Startle; Spiperone | 1991 |
Effects of spiperone, raclopride, SCH 23390 and clozapine on apomorphine inhibition of sensorimotor gating of the startle response in the rat.
Topics: Analysis of Variance; Animals; Apomorphine; Benzazepines; Clozapine; Male; Raclopride; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Reflex, Startle; Salicylamides; Schizophrenia; Spiperone | 1991 |
Dopaminergic regulation of dopamine release from PC12 cells via a pertussis toxin-sensitive G protein.
Topics: Adrenal Gland Neoplasms; Animals; Apomorphine; Cell Line; Dopamine; Dopamine Antagonists; Ergolines; GTP-Binding Proteins; Haloperidol; Nicotine; Pertussis Toxin; Pheochromocytoma; Potassium; Quinpirole; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone; Virulence Factors, Bordetella | 1991 |
Permanent haloperidol-induced dopamine receptor up-regulation in the ovariectomized rat.
Topics: Animals; Apomorphine; Female; Haloperidol; Ovariectomy; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Reference Values; Spiperone; Stereotyped Behavior; Time Factors; Up-Regulation | 1991 |
On the mechanism of mergocryptine-induced suppression of dopamine turnover in the rat striatum.
Topics: Animals; Apomorphine; Benzazepines; Corpus Striatum; Dopamine; Ergolines; Half-Life; Male; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1991 |
Neurochemical and behavioral effects of acute and chronic treatment with apomorphine in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Behavior, Animal; Binding, Competitive; Brain Chemistry; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Hydrazines; Kinetics; Limbic System; Male; Motor Activity; Rats; Rats, Inbred Strains; Spiperone | 1991 |
Structural differences between dopamine D2 receptors present in a rat pituitary adenoma and in transplantable rat pituitary tumors 7315a and MtTW15.
Topics: Adenoma; Animals; Apomorphine; Binding, Competitive; Carrier Proteins; Chemical Phenomena; Chemistry; Dopamine Agents; Ethylmaleimide; Neoplasm Transplantation; Pituitary Neoplasms; Rats; Receptors, Dopamine; Receptors, Dopamine D2; Solubility; Spiperone | 1990 |
Potential antipsychotic agents 5. Synthesis and antidopaminergic properties of substituted 5,6-dimethoxysalicylamides and related compounds.
Topics: Animals; Antipsychotic Agents; Apomorphine; Binding Sites; Chemical Phenomena; Chemistry; Dopamine Antagonists; Male; Raclopride; Rats; Rats, Inbred Strains; Salicylamides; Spiperone; Structure-Activity Relationship | 1990 |
Potential antipsychotic agents. 7. Synthesis and antidopaminergic properties of the atypical highly potent (S)-5-bromo-2,3-dimethoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]benzamide and related compounds. A comparative study.
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Benzamides; Chemical Phenomena; Chemistry; Corpus Striatum; Dopamine Antagonists; Hydrogen Bonding; Male; Molecular Structure; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Remoxipride; Salicylamides; Spiperone; Structure-Activity Relationship | 1990 |
Single apomorphine pretreatment results in a rapid decline in high-affinity dopamine binding to the striatal dopamine D-2 receptor.
Topics: Animals; Apomorphine; Corpus Striatum; Depression, Chemical; Dopamine; GTP-Binding Proteins; Kinetics; Male; Mice; Receptors, Dopamine; Spiperone | 1990 |
Synthesis and pharmacology of the enantiomers of cis-7-hydroxy-3-methyl-2-(dipropylamino)tetralin.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Apomorphine; Binding, Competitive; Cattle; Chemical Phenomena; Chemistry, Physical; Computer Simulation; Crystallography; Dihydroxyphenylalanine; Dopamine Antagonists; In Vitro Techniques; Isomerism; Male; Molecular Conformation; Molecular Structure; Motor Activity; Rats; Reserpine; Spiperone; Structure-Activity Relationship; Tetrahydronaphthalenes; X-Ray Diffraction | 1990 |
Behavioral demonstration of a reciprocal interaction between dopamine receptor subtypes in the mouse striatum: possible involvement of the striato-nigral pathway.
Topics: Animals; Apomorphine; Corpus Striatum; Dose-Response Relationship, Drug; Mice; Mice, Inbred C57BL; Motor Activity; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Reference Values; Spiperone; Stereotyped Behavior; Substantia Nigra | 1990 |
The interaction of clozapine with dopamine D1 versus dopamine D2 receptor-mediated function: behavioural indices.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Behavior, Animal; Benzazepines; Clozapine; Dopamine; Grooming; Male; Quinolines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone | 1990 |
D2 dopamine receptors modulate calcium channel currents and catecholamine secretion in bovine adrenal chromaffin cells.
Topics: Adrenal Glands; Animals; Apomorphine; Calcium; Calcium Channels; Cattle; Cells, Cultured; Chromaffin Granules; Chromaffin System; Norepinephrine; Potassium; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone | 1990 |
Clozapine fails to prevent the development of haloperidol-induced behavioral hypersensitivity in a cotreatment paradigm.
Topics: Animals; Apomorphine; Behavior, Animal; Binding, Competitive; Brain Chemistry; Clozapine; Corpus Striatum; Dopamine; Drug Interactions; Haloperidol; Male; Rats; Rats, Inbred Strains; Spiperone; Stereotyped Behavior; Thioridazine | 1990 |
Ethanol reduces tolerance, sensitization, and up-regulation of D2-receptors after subchronic haloperidol.
Topics: Animals; Apomorphine; Behavior, Animal; Body Weight; Dose-Response Relationship, Drug; Drug Tolerance; Ethanol; Female; Haloperidol; Kinetics; Postural Balance; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Up-Regulation | 1990 |
Thioridazine chronic administration: a behavioural and autoradiographic study.
Topics: Animals; Apomorphine; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Thioridazine | 1990 |
Pretreatment with an irreversible muscarinic agonist affects responses to apomorphine.
Topics: Animals; Apomorphine; Brain; Cholinergic Fibers; Male; Motor Activity; Pyrrolidinones; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Muscarinic; Spiperone; Stereotyped Behavior | 1990 |
Inhibition of inositol phospholipid breakdown by D2 dopamine receptors in dissociated bovine anterior pituitary cells.
Topics: Animals; Apomorphine; Biological Assay; Butaclamol; Cattle; Dopamine; In Vitro Techniques; Inositol Phosphates; Phosphatidylinositols; Pituitary Gland, Anterior; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Sugar Phosphates; Sulpiride | 1985 |
Dopamine antagonists reduce spontaneous electrical activity in cultured mammalian neurons from ventral mesencephalon.
Topics: Action Potentials; Animals; Apomorphine; Butaclamol; Cells, Cultured; Dibenzocycloheptenes; Dopamine Antagonists; Fetus; Haloperidol; Membrane Potentials; Mesencephalon; Mice; Mice, Inbred ICR; Neurons; Receptors, Dopamine; Spinal Cord; Spiperone | 1986 |
In vitro characterisation of dopamine receptors in the superior colliculus of the rat.
Topics: Animals; Apomorphine; Binding, Competitive; Butaclamol; Catecholamines; Corpus Striatum; Haloperidol; In Vitro Techniques; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Serotonin; Spiperone; Sulpiride; Superior Colliculi; Synaptosomes | 1987 |
Thermodynamic analysis of antagonist and agonist interactions with dopamine receptors.
Topics: Animals; Apomorphine; Butaclamol; Caudate Nucleus; Haloperidol; In Vitro Techniques; Microsomes; Receptors, Dopamine; Sheep; Spiperone; Temperature; Thermodynamics | 1988 |
Dopamine receptors on adrenal chromaffin cells modulate calcium uptake and catecholamine release.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Glands; Animals; Apomorphine; Butaclamol; Calcium; Calcium Radioisotopes; Catecholamines; Cattle; Cells, Cultured; Chromaffin System; Electric Conductivity; Haloperidol; Ion Channels; Nicotine; Potassium; Receptors, Dopamine; Spiperone; Sulpiride | 1988 |
Immuno-photoaffinity labeling of the D2-dopamine receptor.
Topics: Affinity Labels; Animals; Apomorphine; Azides; Butaclamol; Cattle; Corpus Striatum; Haloperidol; Immunologic Techniques; Kinetics; Molecular Weight; Photochemistry; Receptors, Dopamine; Spiperone | 1988 |
Effects of chronic haloperidol on stress-induced oral behaviour in rats.
Topics: Animals; Apomorphine; Behavior, Animal; Body Weight; Corpus Striatum; Feeding Behavior; Haloperidol; Male; Rats; Rats, Inbred Strains; Reaction Time; Spiperone; Stereotyped Behavior; Stress, Psychological | 1989 |
Chronic estrogen treatment promotes a functional uncoupling of the D2 dopamine receptor in rat anterior pituitary gland.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Binding, Competitive; Cell Membrane; Diethylstilbestrol; GTP-Binding Proteins; Guanine Nucleotides; Guanylyl Imidodiphosphate; Male; Organ Size; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Inbred F344; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Vasoactive Intestinal Peptide | 1989 |
Synthesis and D2 dopaminergic activity of pyrrolidinium, tetrahydrothiophenium, and tetrahydrothiophene analogues of sulpiride.
Topics: Acetylcholine; Animals; Apomorphine; Cell Membrane; Chemical Phenomena; Chemistry; Corpus Striatum; Dopamine Antagonists; Potassium; Pyrrolidines; Rats; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Structure-Activity Relationship; Sulpiride; Thiophenes | 1989 |
2-Haloaporphines as potent dopamine agonists.
Topics: Animals; Apomorphine; Aporphines; Chemical Phenomena; Chemistry; Molecular Structure; Pituitary Gland, Anterior; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Structure-Activity Relationship; Swine | 1989 |
Are the catecholestrogens involved in estrogen-induced striatal dopamine receptor supersensitivity?
Topics: Animals; Apomorphine; Behavior, Animal; Binding, Competitive; Corpus Striatum; Estrogens; Estrogens, Catechol; Female; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Time Factors | 1989 |
Definition of the in-vivo binding of [3H]spiperone in rat brain using substituted benzamide drugs.
Topics: Amisulpride; Animals; Apomorphine; Benzamides; Binding, Competitive; Brain Chemistry; Female; Haloperidol; Rats; Rats, Inbred Strains; Spiperone; Stereotyped Behavior; Sulpiride | 1989 |
Catecholamine receptors regulating serotonin N-acetyltransferase activity and melatonin content of chicken retina and pineal gland: D2-dopamine receptors in retina and alpha-2 adrenergic receptors in pineal gland.
Topics: Acetyltransferases; Adrenergic beta-Antagonists; Animals; Apomorphine; Arylamine N-Acetyltransferase; Chickens; Clonidine; Darkness; Dopamine Antagonists; Light; Male; Melatonin; Pineal Gland; Receptors, Adrenergic, beta; Receptors, Dopamine; Receptors, Dopamine D2; Reference Values; Retina; Spiperone; Yohimbine | 1989 |
Association of two pertussis toxin-sensitive G-proteins with the D2-dopamine receptor from bovine striatum.
Topics: Adenosine Diphosphate; Animals; Apomorphine; Blotting, Western; Cattle; Chromatography, Affinity; Corpus Striatum; Dopamine Agents; GTP Phosphohydrolases; GTP-Binding Proteins; Guanine Nucleotides; Kinetics; Membranes; Pertussis Toxin; Receptors, Dopamine; Solubility; Spiperone; Virulence Factors, Bordetella | 1989 |
CI-943, a potential antipsychotic agent. II. Neurochemical effects.
Topics: Animals; Antipsychotic Agents; Apomorphine; Brain Chemistry; Clozapine; Dopamine; Haloperidol; Imidazoles; In Vitro Techniques; Male; Mice; Neurotransmitter Agents; Norepinephrine; Prolactin; Pyrimidines; Rats; Rats, Inbred Strains; Serotonin; Spiperone | 1989 |
Systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine reduces the release of [3H]dopamine from rat striatal slices.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Acetylcholine; Animals; Apomorphine; Corpus Striatum; Dopamine; Female; In Vitro Techniques; Kinetics; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Spiperone | 1989 |
Dopamine D2 receptors in the anterior pituitary: a single population without reciprocal antagonist/agonist states.
Topics: Animals; Apomorphine; Binding, Competitive; Butaclamol; Butyrophenones; Dopamine; Dopamine Antagonists; Guanylyl Imidodiphosphate; Norepinephrine; Pituitary Gland, Anterior; Receptors, Dopamine; Receptors, Dopamine D2; Serotonin; Sodium Chloride; Spiperone; Swine; Tetrahydronaphthalenes | 1985 |
Effect of buflomedil (4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxy phenyl)-1-butanone hydrochloride) on the function of striatal dopaminergic neurons.
Topics: Animals; Apomorphine; Benzazepines; Corpus Striatum; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Male; Pyrrolidines; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Muscarinic; Scopolamine; Spiperone; Sulpiride; Vasodilator Agents | 1989 |
Behavioral and neurochemical modifications induced by apomorphine treatment.
Topics: Animals; Apomorphine; Brain; Corpus Striatum; Male; Nucleus Accumbens; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1989 |
A permanent dopamine receptor up-regulation in the ovariectomized rat.
Topics: Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Female; Kinetics; Ovariectomy; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Time Factors | 1989 |
Extra-hypothalamic dopamine is not involved in the effects of hyperprolactinemia on male copulatory behavior.
Topics: Animals; Apomorphine; Brain; Copulation; Dopamine; Dose-Response Relationship, Drug; Hyperprolactinemia; Male; Motor Activity; Rats; Rats, Inbred F344; Receptors, Dopamine; Sexual Behavior, Animal; Spiperone; Stereotyped Behavior | 1989 |
Neurochemical and behavioural evidence that dopamine D-2 receptors in striatum couple to the Ni regulatory protein and inhibition of cyclic AMP accumulation.
Topics: Adenylate Cyclase Toxin; Animals; Apomorphine; Behavior, Animal; Benzazepines; Cholera Toxin; Corpus Striatum; Cyclic AMP; Dopamine; GTP-Binding Proteins; In Vitro Techniques; Male; Pertussis Toxin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Sulpiride; Virulence Factors, Bordetella | 1987 |
Further in vitro and in vivo studies with the putative presynaptic dopamine agonist N,N-dipropyl-7-hydroxy-2-aminotetralin.
Topics: 4-Butyrolactone; Animals; Apomorphine; Binding, Competitive; Corpus Striatum; Dopamine; In Vitro Techniques; Male; Motor Activity; Naphthalenes; Piperazines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Neurotransmitter; Spiperone; Substantia Nigra; Synaptosomes; Tetrahydronaphthalenes | 1987 |
The bindings of 3H-prazosin and 3H-yohimbine to alpha adrenoceptors in the guinea-pig stomach.
Topics: Animals; Apomorphine; Binding, Competitive; Cell Membrane; Domperidone; Dopamine; Gastric Mucosa; Guinea Pigs; Male; Prazosin; Receptors, Adrenergic, alpha; Spiperone; Sympatholytics; Sympathomimetics; Tritium; Yohimbine | 1988 |
Improved recovery of nigro-striatally hemitransected rats induced by (Nle4, D-Phe7)alpha-MSH: a central effect.
Topics: alpha-MSH; Animals; Apomorphine; Cerebral Ventricles; Corpus Striatum; Injections, Intraventricular; Kinetics; Male; Motor Activity; Nerve Fibers; Posture; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reference Values; Reflex; Spiperone; Substantia Nigra | 1988 |
Long-term consequence of early iron-deficiency on dopaminergic neurotransmission in rats.
Topics: Aging; Animals; Animals, Newborn; Apomorphine; Brain; Dopamine; Iron; Iron Deficiencies; Motor Activity; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Synaptic Transmission; Time Factors | 1986 |
[Stimulation by cerulein--an analog of the octapeptide cholecystokinin--of 3H-spiroperidol binding after the long-term administration of neuroleptics].
Topics: Animals; Antipsychotic Agents; Apomorphine; Brain; Butyrophenones; Ceruletide; Drug Interactions; Male; Mice; Spiperone; Stimulation, Chemical; Time Factors; Tritium | 1985 |
Differential involvement of dopamine D-1 and D-2 receptors in the circling behaviour induced by apomorphine, SK & F 38393, pergolide and LY 171555 in 6-hydroxydopamine-lesioned rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Animals; Antiparkinson Agents; Antipsychotic Agents; Apomorphine; Appetite Depressants; Benzazepines; Electric Stimulation; Ergolines; Humans; Hydroxydopamines; Male; Oxidopamine; Pergolide; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Sympathectomy, Chemical; Time Factors | 1985 |
Interaction of SCH 23390, a D-1-selective antagonist, with the anterior pituitary D-2 receptors and prolactin secretion in the rat.
Topics: Animals; Antipsychotic Agents; Apomorphine; Benzazepines; In Vitro Techniques; Male; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone; Sulpiride | 1985 |
Prolonged inhibition of striatal dopamine receptor sites by isofloxythepin.
Topics: Animals; Antipsychotic Agents; Apomorphine; Corpus Striatum; Dibenzothiepins; Dose-Response Relationship, Drug; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1985 |
Acute cyanide intoxication and central transmitter systems.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amino Acids; Animals; Apomorphine; Brain; Cyanides; Cyclic GMP; Dopamine; gamma-Aminobutyric Acid; Homovanillic Acid; Levodopa; Male; Neurotransmitter Agents; Norepinephrine; Rats; Rats, Inbred Strains; Spiperone | 1985 |
Effects of remoxipride and some related new substituted salicylamides on rat brain receptors.
Topics: Adenylyl Cyclases; Animals; Antipsychotic Agents; Apomorphine; Benzamides; Brain; Domperidone; Dopamine; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Neurotransmitter; Receptors, Serotonin; Remoxipride; Salicylamides; Spiperone; Structure-Activity Relationship; Tetrahydronaphthalenes; Tritium | 1986 |
Differential effect of repeated treatment with L-dopa on dopamine-D1 or -D2 receptors.
Topics: Adenylyl Cyclases; Animals; Antipsychotic Agents; Apomorphine; Benzazepines; Hydroxydopamines; Levodopa; Male; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1986 |
Synthesis and neuroleptic activity of a series of 1-[1-(benzo-1,4-dioxan-2-ylmethyl)-4-piperidinyl]benzim idazolone derivatives.
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Benzimidazoles; Brain; Catalepsy; Cattle; Chemical Phenomena; Chemistry; Male; Mice; Piperidines; Rats; Receptors, Dopamine; Spiperone; Structure-Activity Relationship | 1987 |
Antipsychotic activity of substituted gamma-carbolines.
Topics: Animals; Antipsychotic Agents; Apomorphine; Avoidance Learning; Carbolines; Male; Mice; Rats; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Structure-Activity Relationship | 1987 |
Combined analgesic/neuroleptic activity in N-butyrophenone prodine-like compounds.
Topics: Adenylyl Cyclase Inhibitors; Alphaprodine; Analgesics; Animals; Antipsychotic Agents; Apomorphine; Butyrophenones; Dihydromorphine; Mice; Spiperone; Stereotyped Behavior | 1987 |
Effects of continuous administration for 12 months of amine-depleting drugs and chlorpromazine on striatal dopamine function in the rat.
Topics: Animals; Apomorphine; Body Weight; Chlorpromazine; Corpus Striatum; Dopamine; Homovanillic Acid; Indoles; Kinetics; Male; Motor Activity; Piperazines; Rats; Rats, Inbred Strains; Reserpine; Spiperone; Stereotyped Behavior; Thioxanthenes | 1987 |
Interaction of L-prolyl-L-leucyl glycinamide with dopamine D2 receptor: evidence for modulation of agonist affinity states in bovine striatal membranes.
Topics: Animals; Apomorphine; Cattle; Corpus Striatum; Guanylyl Imidodiphosphate; MSH Release-Inhibiting Hormone; Osmolar Concentration; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone | 1988 |
Blockade of hippocampal dopamine (DA) receptors: a tool for antipsychotics with low extrapyramidal side effects.
Topics: Animals; Antipsychotic Agents; Apomorphine; Corpus Striatum; Dose-Response Relationship, Drug; Extrapyramidal Tracts; Hippocampus; Mice; Mice, Inbred Strains; Motor Activity; Neural Pathways; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone | 1988 |
Differential alteration in striatal dopaminergic and cortical serotonergic receptors induced by repeated administration of haloperidol or centbutindole in rats.
Topics: 5-Hydroxytryptophan; Animals; Antipsychotic Agents; Apomorphine; Cerebral Cortex; Corpus Striatum; Haloperidol; Male; Pyrazines; Rats; Receptors, Dopamine; Receptors, Serotonin; Spiperone; Stereotyped Behavior | 1988 |
2-Phenylpyrroles as conformationally restricted benzamide analogues. A new class of potential antipsychotics. 2.
Topics: Animals; Antipsychotic Agents; Apomorphine; Avoidance Learning; Benzamides; Chemical Phenomena; Chemistry, Physical; Conditioning, Classical; Corpus Striatum; Dioxanes; Mice; Pyrroles; Rats; Spiperone | 1988 |
Adrenocortical hormone status affects responses to dopamine receptor agonists.
Topics: Adrenal Cortex Hormones; Adrenalectomy; Animals; Apomorphine; Behavior, Animal; Benzazepines; Body Temperature; Corticosterone; Dopamine Agents; Ergolines; Male; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1988 |
Definition of the in-vivo accumulation of [3H]spiperone in brain using haloperidol and sulpiride to determine functional dopamine receptor occupation.
Topics: Animals; Apomorphine; Brain Chemistry; Corpus Striatum; Female; Haloperidol; Homovanillic Acid; Limbic System; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Sulpiride | 1988 |
Regulation of anterior pituitary D2 dopamine receptors by magnesium and sodium ions.
Topics: Animals; Apomorphine; Dopamine; Guanine Nucleotides; Magnesium; Pituitary Gland, Anterior; Receptors, Dopamine; Receptors, Dopamine D2; Sodium; Spiperone; Swine | 1985 |
Subtypes of the 5-HT receptor mediating the behavioural responses to 5-methoxy-N,N-dimethyltryptamine in the rat.
Topics: Animals; Apomorphine; Behavior, Animal; Betaxolol; Haloperidol; Ketanserin; Male; Pindolol; Piperidines; Prazosin; Propanolamines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Reserpine; Spiperone | 1985 |
Identification of dopamine "D3" and "D4" binding sites, labelled with [3H]2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene, as high agonist affinity states of the D1 and D2 dopamine receptors, respectively.
Topics: Acetylcholine; Adenylyl Cyclase Inhibitors; Animals; Apomorphine; Benzazepines; Binding Sites; Binding, Competitive; Corpus Striatum; Dopamine; Dopamine Antagonists; Male; Naphthalenes; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone; Tetrahydronaphthalenes | 1986 |
[3H]Fluphenazine binding to brain membranes: simultaneous measurement of D-1 and D-2 receptor sites.
Topics: Animals; Apomorphine; Benzazepines; Binding, Competitive; Brain; Cell Membrane; Corpus Striatum; Fluphenazine; Kinetics; Male; Mice; Mice, Inbred C57BL; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone; Tissue Distribution | 1986 |
Dopamine D2 receptors and dopamine metabolism. Relationship between biochemical and behavioural effects of substituted benzamide drugs.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Benzamides; Brain Chemistry; Dopamine; Homovanillic Acid; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Stereotyped Behavior | 1986 |
Comparison of motor depressant effects of caerulein and N-propylnorapomorphine in mice.
Topics: 5,7-Dihydroxytryptamine; Animals; Apomorphine; Ceruletide; Depression, Chemical; Exploratory Behavior; Fenclonine; Haloperidol; Hydroxydopamines; Male; Mice; Motor Activity; Nerve Endings; Oxidopamine; Receptors, Dopamine; Receptors, Serotonin; Sincalide; Spiperone | 1986 |
Iron deficiency alters discrete proteins in rat caudate nucleus and nucleus accumbens.
Topics: Albumins; Animals; Apomorphine; Behavior, Animal; Caudate Nucleus; Electrophoresis, Polyacrylamide Gel; Glial Fibrillary Acidic Protein; Iron Deficiencies; Isoelectric Focusing; Male; Molecular Weight; Nerve Tissue Proteins; Nucleus Accumbens; Phosphopyruvate Hydratase; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Septal Nuclei; Spiperone | 1986 |
Dopaminergic 2-aminotetralins: affinities for dopamine D2-receptors, molecular structures, and conformational preferences.
Topics: Apomorphine; Magnetic Resonance Spectroscopy; Molecular Conformation; Naphthalenes; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Structure-Activity Relationship; Tetrahydronaphthalenes; Tritium; X-Ray Diffraction | 1986 |
Dopamine receptor changes in response to prolonged treatment with L-dopa.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Benzazepines; Carbidopa; Corpus Striatum; Dopamine; Hydroxydopamines; Levodopa; Male; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Spiperone; Stereotyped Behavior; Substantia Nigra; Sulpiride | 1986 |
"Selective" D-1 and D-2 receptor antagonists fail to differentially alter supersensitive locomotor behavior in the rat.
Topics: Animals; Apomorphine; Benzazepines; Hydroxydopamines; Kinetics; Male; Motor Activity; Nucleus Accumbens; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone | 1986 |
The benzazepine, SCH 23390, inhibits 3H-NPA binding in mouse brain in vivo.
Topics: Animals; Apomorphine; Benzazepines; Binding, Competitive; Male; Mice; Raclopride; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Salicylamides; Spiperone | 1986 |
The effects of selective dopamine receptor agonists and antagonists on body temperature in rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Benzazepines; Body Temperature; Ergolines; Male; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone | 1987 |
Differential recovery rates of rat D2 dopamine receptors as a function of aging and chronic reserpine treatment following irreversible modification: a key to receptor regulatory mechanisms.
Topics: Aging; Animals; Apomorphine; Corpus Striatum; Guanylyl Imidodiphosphate; Haloperidol; In Vitro Techniques; Kinetics; Male; Quinolines; Radioligand Assay; Rats; Rats, Inbred F344; Receptors, Dopamine; Receptors, Dopamine D2; Reserpine; Spiperone | 1987 |
Characterization of D-2 dopamine receptors in a tumor of the rat anterior pituitary gland.
Topics: Adenylyl Cyclase Inhibitors; Animals; Apomorphine; Colforsin; Dopamine; Female; Guanosine Triphosphate; Pituitary Gland, Anterior; Pituitary Neoplasms; Rats; Rats, Inbred BUF; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone | 1987 |
Characterization of D2 dopamine receptors in dopamine-resistant prolactin-secreting rat pituitary tumors 7315a and MtTW15.
Topics: Affinity Labels; Animals; Apomorphine; Cell Membrane; Dopamine; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Female; Guanylyl Imidodiphosphate; Molecular Weight; Neoplasm Transplantation; Photochemistry; Pituitary Neoplasms; Prolactin; Rats; Rats, Inbred BUF; Rats, Inbred WF; Receptors, Dopamine; Receptors, Dopamine D2; Solubility; Spiperone | 1987 |
Dopamine D1 and D2 receptors are sensitive to the cationic form of apomorphine.
Topics: Animals; Apomorphine; Benzazepines; Dogs; Hydrogen-Ion Concentration; In Vitro Techniques; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone | 1987 |
Mesolimbic dopaminergic supersensitivity following electrical kindling of the amygdala.
Topics: Amygdala; Animals; Apomorphine; Electric Stimulation; Kindling, Neurologic; Limbic System; Male; Nucleus Accumbens; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Seizures; Spiperone; Stereotyped Behavior; Tritium | 1988 |
Binding of [125I]-N-(p-aminophenethyl)spiroperidol to the D-2 dopamine receptor in the neurointermediate lobe of the rat pituitary gland: a thermodynamic study.
Topics: Animals; Apomorphine; Female; Fluphenazine; Guanylyl Imidodiphosphate; In Vitro Techniques; Iodine Radioisotopes; Male; Pituitary Gland; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Thermodynamics | 1988 |
Enhanced stereotypic behavior by chronic treatment with bromocriptine accompanies increase of D-1 receptor binding.
Topics: Animals; Apomorphine; Benzazepines; Bromocriptine; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone; Stereotyped Behavior | 1988 |
Behavioral and biochemical expression of D1-receptor supersensitivity following SCH 23390 repeated administrations.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Benzazepines; Corpus Striatum; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone; Stereotyped Behavior | 1988 |
In vivo labelling of rat brain dopamine D-2 receptors. Stereoselective blockade by the D-2 antagonist raclopride and its enantiomer of 3H-spiperone, 3H-N,N-propylnorapomorphine and 3H-raclopride binding in the rat brain.
Topics: Animals; Apomorphine; Binding, Competitive; Brain; Kinetics; Male; Organ Specificity; Raclopride; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Salicylamides; Spiperone; Stereoisomerism | 1988 |
The possible role of 2-hydroxyestradiol in the development of estrogen-induced striatal dopamine receptor hypersensitivity.
Topics: Animals; Apomorphine; Corpus Striatum; Estradiol; Estrogens, Catechol; Female; Humans; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1985 |
SCH 23390 may alter dopamine-mediated motor behaviour via striatal D-1 receptors.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcholine; Animals; Apomorphine; Benzazepines; Corpus Striatum; Cyclic AMP; Dopamine; Female; Humans; In Vitro Techniques; Motor Activity; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Thioxanthenes | 1985 |
Increased sensitivity to dopamine agonists following a single dose of morphine or levorphanol in mice.
Topics: Animals; Apomorphine; Brain; Brain Stem; Cerebral Cortex; Chlorides; Corpus Striatum; Dextrorphan; Drug Synergism; Hippocampus; Levorphanol; Lithium; Lithium Chloride; Male; Mice; Morphine; Motor Activity; Naloxone; Narcotics; Receptors, Dopamine; Spiperone | 1985 |
Alkylation of striatal dopamine receptors abolishes stereotyped behavior but has no effect on dopamine stimulated adenylate cyclase activity.
Topics: Adenylyl Cyclases; Alkylating Agents; Animals; Apomorphine; Benzazepines; Corpus Striatum; Male; Quinolines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Sulpiride | 1988 |
BRL 20596, a novel anilide with central dopamine antagonist activity.
Topics: Animals; Apomorphine; Avoidance Learning; Behavior, Animal; Brain Chemistry; Catalepsy; Dextroamphetamine; Dopamine Antagonists; Drug Synergism; Electroencephalography; Hemodynamics; Hexobarbital; Homovanillic Acid; Isonipecotic Acids; Male; Mice; Motor Activity; Prolactin; Rats; Rats, Inbred Strains; Spiperone; Stereotyped Behavior | 1986 |
Behavioral and biochemical studies of dopamine receptor sensitivity in differentially housed mice.
Topics: Animals; Apomorphine; Brain Chemistry; Dihydroxyphenylalanine; Drug Interactions; Male; Mice; Motor Activity; Receptors, Dopamine; Reserpine; Social Isolation; Spiperone; Tyrosine | 1986 |
Functional compensation by transplantation of cell suspensions of embryonic mesencephalon into the striatum of rats with 6-hydroxydopamine lesions.
Topics: Animals; Apomorphine; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Female; Hydrazines; Hydroxydopamines; Mesencephalon; Oxidopamine; Rats; Rats, Inbred Strains; Spiperone | 1986 |
Hypothyroidism leads to increased dopamine receptor sensitivity and concentration.
Topics: Animals; Apomorphine; Body Temperature; Conditioning, Operant; Haloperidol; Hypothyroidism; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Thyroid Hormones; Thyrotropin-Releasing Hormone; Tritium | 1986 |
Differential effects of proglumide on mesolimbic and nigrostriatal dopamine function.
Topics: Animals; Apomorphine; Corpus Striatum; Dopamine; Glutamine; Haloperidol; Kainic Acid; Kinetics; Limbic System; Male; Proglumide; Rats; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Substantia Nigra | 1987 |
Alkylation of the bovine anterior pituitary D2-dopamine receptor: inconsistency with predictions of the ternary complex model.
Topics: Alkylation; Animals; Apomorphine; Binding, Competitive; Cattle; Cell Membrane; Computer Simulation; Dopamine Antagonists; Fluphenazine; GTP-Binding Proteins; In Vitro Techniques; Ligands; Pituitary Gland, Anterior; Receptors, Dopamine; Spiperone; Structure-Activity Relationship | 1987 |
Comparison of the effects of fluphenazine-N-mustard on dopamine binding sites and on behavior induced by apomorphine in supersensitive mice.
Topics: Animals; Apomorphine; Binding, Competitive; Fluphenazine; Hydroxydopamines; Male; Mice; Oxidopamine; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1987 |
Chronic haloperidol does not alter agonist affinity for dopamine receptors in vitro.
Topics: Animals; Apomorphine; Binding, Competitive; Corpus Striatum; Haloperidol; Indoles; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone | 1985 |
Complete conversion of brain D2 dopamine receptors from the high- to the low-affinity state for dopamine agonists, using sodium ions and guanine nucleotide.
Topics: Animals; Apomorphine; Brain; Guanine Nucleotides; In Vitro Techniques; Ketanserin; Male; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sodium; Spiperone; Tetrahydronaphthalenes; Tritium | 1985 |
Differential alteration of striatal D-1 and D-2 receptors induced by the long-term administration of haloperidol, sulpiride or clozapine to rats.
Topics: Animals; Apomorphine; Clozapine; Corpus Striatum; Dibenzazepines; Dose-Response Relationship, Drug; Haloperidol; Humans; Kinetics; Long-Term Care; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone; Stereotyped Behavior; Sulpiride; Thioxanthenes | 1985 |
Behavioral and biochemical effect of chronic treatment with D-1 and/or D-2 dopamine agonists in MPTP monkeys.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Benzazepines; Brain Chemistry; Dopamine; Dyskinesia, Drug-Induced; Female; Homovanillic Acid; Macaca fascicularis; Motor Activity; Parkinson Disease, Secondary; Pyridines; Receptors, Dopamine; Spiperone | 1988 |
On the mechanism of potentiation of apomorphine-induced stereotypy due to electroconvulsive shock.
Topics: Animals; Apomorphine; Blood-Brain Barrier; Corpus Striatum; Dopamine; Electroshock; Male; Rats; Receptors, Dopamine; Seizures; Spiperone; Stereotyped Behavior | 1987 |
SCH23390 effects on apomorphine-induced responses of nigral dopaminergic neurons.
Topics: Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Benzazepines; Corpus Striatum; Dopamine Antagonists; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Substantia Nigra; Tritium | 1986 |
Selective dopamine D2 receptor reduction enhances a D1-mediated oral dyskinesia in rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Benzazepines; Dopamine Antagonists; Jaw; Rats; Rats, Inbred F344; Rats, Inbred Strains; Receptors, Dopamine; Species Specificity; Spiperone; Stereotyped Behavior; Tetrabenazine | 1986 |
Modification of the development of acute opiate tolerance by increased dopamine receptor sensitivity.
Topics: Animals; Apomorphine; Behavior, Animal; Drug Interactions; Drug Tolerance; Levorphanol; Lithium; Male; Mice; Morphine; Naloxone; Narcotics; Opioid-Related Disorders; Receptors, Dopamine; Spiperone; Substance Withdrawal Syndrome | 1987 |
A dietary haloperidol regimen for inducing dopamine receptor supersensitivity in rats.
Topics: Administration, Oral; Animals; Apomorphine; Brain; Drug Resistance; Haloperidol; Injections, Subcutaneous; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1987 |
Ascorbic acid reduces accumulation of [3H]spiperone in mouse striatum in vivo.
Topics: Animals; Apomorphine; Ascorbic Acid; Cerebellum; Corpus Striatum; Depression, Chemical; Dopamine Antagonists; Drug Synergism; Haloperidol; Mice; Receptors, Dopamine; Spiperone | 1987 |
Effect of long-term dosing with tiapride on brain dopamine receptors and metabolism in rats. Comparative study with sulpiride and haloperidol.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antiparkinson Agents; Apomorphine; Benzamides; Brain Chemistry; Dopamine; Haloperidol; Homovanillic Acid; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Sulpiride; Tiapamil Hydrochloride | 1987 |
Chronically administered morphine increases dopamine receptor sensitivity in mice.
Topics: Analgesia; Animals; Apomorphine; Behavior, Animal; Binding Sites; Brain; Drug Implants; Drug Tolerance; Hypothermia; Lithium; Male; Mice; Morphine; Naloxone; Receptors, Dopamine; Spiperone; Substance Withdrawal Syndrome | 1986 |
Tracer and maximal specific binding of tritiated spiperone or N-n-propylnorapomorphine to quantify dopamine receptors in rat brain regions in vivo.
Topics: Animals; Apomorphine; Brain; Brain Mapping; Butyrophenones; Rats; Receptors, Dopamine; Spiperone | 1986 |
Characterization of a dopaminergic receptor that modulates adrenomedullary catecholamine release.
Topics: Adrenal Medulla; Animals; Apomorphine; Binding, Competitive; Catecholamines; Cattle; Cell Membrane; Haloperidol; Kinetics; Nicotine; Rats; Receptors, Dopamine; Spiperone | 1986 |
Synthesis and pharmacological evaluation of some 6-substituted 7-methyl-1,4-dioxa-7-azaspiro[4.5]decanes as potential dopamine agonists.
Topics: Alkylation; Animals; Apomorphine; Behavior, Animal; Cats; Corpus Striatum; Dopamine; Heart Rate; Indoles; Male; Posture; Pyrrolidines; Rats; Rats, Inbred Strains; Spiperone; Spiro Compounds | 1986 |
Role of assay conditions in determining agonist potency at D2 dopamine receptors in striatal homogenates.
Topics: Animals; Apomorphine; Binding, Competitive; Corpus Striatum; Dopamine; Guanosine Triphosphate; Haloperidol; Kinetics; Magnesium; Male; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1986 |
Elevation of acetylcholine levels in striatum of rat brain by LY163502, trans-(-)-5,5a,6,7,8,9a,10-octahydro-6-propylpyrimido less than 4,5-g greater than quinolin-2-amine dihydrochloride, a potent and stereospecific dopamine (D2) agonist.
Topics: Acetylcholine; Adenylyl Cyclases; Animals; Apomorphine; Clonidine; Corpus Striatum; Dopamine; Dopamine Antagonists; Enzyme Activation; Ergolines; Pergolide; Quinolines; Rats; Receptors, Dopamine; Spiperone | 1986 |
Characterization of high-affinity dopamine D2 receptors and modulation of affinity states by guanine nucleotides in cholate-solubilized bovine striatal preparations.
Topics: Animals; Apomorphine; Binding, Competitive; Cattle; Cholic Acid; Cholic Acids; Computers; Corpus Striatum; Domperidone; Guanine Nucleotides; Guanylyl Imidodiphosphate; Haloperidol; Kinetics; Receptors, Dopamine; Solubility; Spiperone | 1986 |
Dopamine receptors are located on rods in bovine retina.
Topics: Animals; Apomorphine; Autoradiography; Cattle; Photoreceptor Cells; Receptors, Dopamine; Retina; Spiperone | 1986 |
Evidence for dopaminergic binding sites in the human adrenal cortex.
Topics: Adrenal Cortex; Adult; Aged; Apomorphine; Binding, Competitive; Bromocriptine; Domperidone; Dopamine; Epinephrine; Female; Humans; Ketanserin; Male; Metoclopramide; Middle Aged; Receptors, Dopamine; Spiperone; Sulpiride; Time Factors | 1986 |
In situ molecular size of agonist dopamine D-2 binding sites in rat striatum.
Topics: Animals; Apomorphine; Corpus Striatum; Dopamine; Guanosine Triphosphate; Kinetics; Male; Molecular Weight; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sodium Chloride; Spiperone | 1987 |
The effects of a long term dihydroergotoxine treatment on agonist and antagonist striatal dopamine binding sites are dose and age related.
Topics: Aging; Animals; Apomorphine; Binding, Competitive; Corpus Striatum; Dihydroergotoxine; Dose-Response Relationship, Drug; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1986 |
Stereotyped behavior and diabetes mellitus in rats: reduced behavioral effects of amphetamine and apomorphine and reduced in vivo brain binding of [3H]spiroperidol.
Topics: Animals; Apomorphine; Brain; Dextroamphetamine; Diabetes Mellitus, Experimental; Insulin; Male; Motor Activity; Rats; Rats, Inbred Strains; Spiperone; Stereotyped Behavior | 1985 |
Hyperactivity induced by stimulation of separate dopamine D-1 and D-2 receptors in rats with bilateral 6-OHDA lesions.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Benzamides; Benzazepines; Clopenthixol; Dopamine; Dose-Response Relationship, Drug; Ergolines; Flupenthixol; Hydroxydopamines; Hypothalamus; Male; Motor Activity; Oxidopamine; Pergolide; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1985 |
The effects of chronic bromocriptine treatment on behaviour and dopamine receptor binding in the rat striatum.
Topics: Animals; Apomorphine; Bromocriptine; Corpus Striatum; Hydroxydopamines; Kainic Acid; Male; Motor Activity; Muscle Denervation; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Substantia Nigra | 1985 |
Antidopaminergic effects of bisbenzyl and benzyl tetrahydroisoquinoline alkaloids.
Topics: Alkaloids; Animals; Apomorphine; Behavior, Animal; Benzylisoquinolines; Binding, Competitive; Catalepsy; Corpus Striatum; Hydroxydopamines; Isoquinolines; Male; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Rotation; Spiperone; Stereotyped Behavior; Tetrahydroisoquinolines | 1985 |
Potential neuroleptic agents. 4. Chemistry, behavioral pharmacology, and inhibition of [3H]spiperone binding of 3,5-disubstituted N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-methoxysalicylamides.
Topics: Animals; Apomorphine; Chemical Phenomena; Chemistry; Corpus Striatum; Haloperidol; Male; Raclopride; Rats; Rats, Inbred Strains; Receptors, Dopamine; Salicylamides; Spiperone; Stereotyped Behavior; Structure-Activity Relationship | 1986 |
A comparison of motor behaviours in groups of rats distinguished by their climbing response to apomorphine.
Topics: Age Factors; Animals; Apomorphine; Corpus Striatum; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Limbic System; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Time Factors; Tritium | 1986 |
Occupation of dopamine receptors by N-n-propylnorapomorphine or spiperone and acetylcholine levels in the rat striatum.
Topics: Acetylcholine; Animals; Apomorphine; Binding Sites; Butyrophenones; Corpus Striatum; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Time Factors | 1985 |
Interactions of dopaminergic agonists and antagonists with dopaminergic D3 binding sites in rat striatum. Evidence that [3H]dopamine can label a high affinity agonist-binding state of the D1 dopamine receptor.
Topics: Animals; Apomorphine; Binding Sites; Binding, Competitive; Corpus Striatum; Dopamine; Ergot Alkaloids; Flupenthixol; Guanine Nucleotides; In Vitro Techniques; Rats; Receptors, Dopamine; Spiperone; Tritium | 1985 |
Effects of phospholipids on the specific binding of [3H]spiroperidol to the cholate extract of rat brain synaptic membranes.
Topics: Animals; Apomorphine; Brain; Butyrophenones; Cerebellum; Cerebral Cortex; Cholic Acid; Cholic Acids; Corpus Striatum; Detergents; Dopamine; Haloperidol; In Vitro Techniques; Kinetics; Male; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylinositols; Phosphatidylserines; Phospholipids; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Synaptic Membranes; Temperature | 1985 |
Effects of isomers of apomorphines on dopamine receptors in striatal and limbic tissue of rat brain.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Corpus Striatum; Isomerism; Limbic System; Nucleus Accumbens; Olfactory Bulb; Rats; Receptors, Dopamine; Spiperone; Stereoisomerism; Structure-Activity Relationship; Tetrahydronaphthalenes | 1985 |
Effect of duration of haloperidol treatment on DA receptor supersensitization in aging C57BL/6J mice.
Topics: Age Factors; Animals; Apomorphine; Choline O-Acetyltransferase; Corpus Striatum; Haloperidol; Humans; Mice; Mice, Inbred C57BL; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1985 |
Dopaminergic supersensitivity follows ferric chloride-induced limbic seizures.
Topics: Aggression; Amygdala; Animals; Apomorphine; Behavior, Animal; Chlorides; Ferric Compounds; Humans; Iron; Kinetics; Rats; Receptors, Dopamine; Seizures; Spiperone; Stereotyped Behavior | 1985 |
Chronic treatment with clozapine, unlike haloperidol, does not induce changes in striatal D-2 receptor function in the rat.
Topics: Acetylcholine; Animals; Apomorphine; Body Weight; Clozapine; Corpus Striatum; Dibenzazepines; Haloperidol; Humans; Male; Mastication; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Thioxanthenes; Tritium | 1985 |
Striatal dopamine receptor sensitivity after subchronic fencamfamine in the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Corpus Striatum; Homovanillic Acid; Humans; In Vitro Techniques; Kinetics; Male; Motor Activity; Norbornanes; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1985 |
Potential neuroleptic agents. 3. Chemistry and antidopaminergic properties of substituted 6-methoxysalicylamides.
Topics: Animals; Apomorphine; Benzamides; Chemical Phenomena; Chemistry; Corpus Striatum; Dopamine Antagonists; Humans; Hyperkinesis; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Inbred Strains; Salicylamides; Spiperone; Stereotyped Behavior; Structure-Activity Relationship | 1985 |
Central nervous system effect of 2,5-hexane diol.
Topics: Amphetamine; Animals; Apomorphine; Binding Sites; Corpus Striatum; Glycols; Kinetics; Male; Membranes; Mice; Motor Activity; Spiperone; Stereotyped Behavior | 1985 |
Simultaneous catalepsy and apomorphine-induced stereotypic behavior in mice.
Topics: Animals; Apomorphine; Catalepsy; Chlorpromazine; Domperidone; Drug Interactions; Haloperidol; Injections, Intraventricular; Mice; Spiperone; Stereotyped Behavior; Sulpiride | 1985 |
Differential effects of haloperidol decanoate, a long-acting neuroleptic, in behavioral and biochemical tests.
Topics: Animals; Apomorphine; Avoidance Learning; Behavior, Animal; Biogenic Amines; Brain Chemistry; Corpus Striatum; Female; Haloperidol; Injections, Intramuscular; Injections, Intraventricular; Male; Mice; Prolactin; Rats; Rats, Inbred Strains; Spiperone; Time Factors | 1985 |
The effect of dopamine receptor agonist treatment on haloperidol-induced supersensitivity in mice.
Topics: alpha-Methyltyrosine; Animals; Apomorphine; Corpus Striatum; Dextroamphetamine; Haloperidol; Levodopa; Male; Methyltyrosines; Mice; Motor Activity; Receptors, Dopamine; Reserpine; Spiperone | 1985 |
Possible dissociation of central dopamine receptor antagonism and cataleptic behavior.
Topics: Animals; Apomorphine; Catalepsy; Haloperidol; Male; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Time Factors | 1985 |
Chronic clorgyline and pargyline increase apomorphine-induced stereotypy in the rat.
Topics: Animals; Apomorphine; Cerebral Cortex; Clorgyline; Corpus Striatum; Male; Monoamine Oxidase; Pargyline; Phenethylamines; Propylamines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Serotonin; Spiperone; Stereotyped Behavior; Time Factors | 1985 |
Proceedings: Effects of some dopamine receptor stimulants on cobalt-induced epilepsy in the rat.
Topics: Amphetamine; Animals; Apomorphine; Cobalt; Dopamine; Electroencephalography; Epilepsy; Ergolines; Male; Rats; Receptors, Adrenergic; Spiperone; Stimulation, Chemical | 1974 |
Structure activity relationships of resorcinol substituted ring systems.
Topics: Animals; Apomorphine; Blood Pressure; Cats; Dopamine; Female; Heart Rate; Humans; In Vitro Techniques; Neurons; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Neurotransmitter; Resorcinols; Spiperone; Stereotyped Behavior; Structure-Activity Relationship | 1984 |
Abnormal neuroleptic/dopamine receptors in schizophrenia.
Topics: Adult; Aged; Antipsychotic Agents; Apomorphine; Brain; Caudate Nucleus; Haloperidol; Humans; Middle Aged; Nucleus Accumbens; Receptors, Dopamine; Schizophrenia; Spiperone | 1980 |
Changes in rat striatal dopamine turnover and receptor activity during one years neuroleptic administration.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adenylyl Cyclases; Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Binding Sites; Corpus Striatum; Cyclic AMP; Dopamine; Homovanillic Acid; Male; Rats; Receptors, Dopamine; Spiperone; Thioridazine; Time Factors; Trifluoperazine | 1980 |
Cerebral dopamine function in rats following withdrawal from one year of continuous neuroleptic administration.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adenylyl Cyclases; Animals; Antipsychotic Agents; Apomorphine; Binding Sites; Body Weight; Brain; Corpus Striatum; Dopamine; Homovanillic Acid; Humans; Male; Motor Activity; Mouth; Movement; Rats; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Substance Withdrawal Syndrome; Thioridazine; Time Factors; Trifluoperazine | 1980 |
Alterations in dopamine receptors: effect of lesion and haloperidol treatment.
Topics: Animals; Apomorphine; Corpus Striatum; Haloperidol; Hydroxydopamines; Limbic System; Male; Rats; Receptors, Dopamine; Spiperone; Substantia Nigra; Tyrosine 3-Monooxygenase | 1980 |
3H-Apomorphine receptors in various rat brain regions: a study of specific and nonspecific binding and the influence of chronic neuroleptic treatment.
Topics: Animals; Antipsychotic Agents; Apomorphine; Brain; Female; In Vitro Techniques; Radioligand Assay; Rats; Receptors, Drug; Spiperone; Stereoisomerism; Time Factors | 1980 |
Dopamine receptors, neuroleptics, and schizophrenia.
Topics: Adenylyl Cyclases; Antipsychotic Agents; Apomorphine; Brain; Brain Chemistry; Caudate Nucleus; Dopamine; Guanosine Triphosphate; Haloperidol; Humans; Nucleus Accumbens; Radioligand Assay; Receptors, Dopamine; Schizophrenia; Spiperone | 1981 |
Effect of L-prolyl-L-leucyl-glycinamide (PLG) on neuroleptic-induced catalepsy and dopamine/neuroleptic receptor bindings.
Topics: Animals; Apomorphine; Catalepsy; Dose-Response Relationship, Drug; Haloperidol; Humans; Kinetics; Male; MSH Release-Inhibiting Hormone; Rats; Receptors, Dopamine; Receptors, Opioid; Spiperone | 1981 |
During one year's neuroleptic treatment in rats striatal dopamine receptor blockade decreases but serum prolactin levels remain elevated.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antipsychotic Agents; Apomorphine; Corpus Striatum; Humans; Kinetics; Male; Prolactin; Rats; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Time Factors | 1981 |
Effects of chronic haloperidol, thioridazine and zotepine treatment on apomorphine elicited stereotypic behavior and 3H-spiroperidol binding sites in the striatum of the rat.
Topics: Animals; Antipsychotic Agents; Apomorphine; Binding Sites; Butyrophenones; Corpus Striatum; Dibenzothiepins; Haloperidol; Humans; Male; Rats; Spiperone; Stereotyped Behavior; Thioridazine | 1981 |
Characterisation of the mechanisms by which purported dopamine agonists reduce spontaneous locomotor activity of mice.
Topics: Animals; Antipsychotic Agents; Apomorphine; Bromocriptine; Catecholamines; Dopamine; Dose-Response Relationship, Drug; Imidazolines; Male; Mice; Motor Activity; Prazosin; Receptors, Dopamine; Spiperone; Tetrahydronaphthalenes; Yohimbine | 1981 |
Chronic continuous administration of neuroleptic drugs alters cerebral dopamine receptors and increases spontaneous dopaminergic action in the striatum.
Topics: Acetylcholine; Animals; Antipsychotic Agents; Apomorphine; Corpus Striatum; Rats; Receptors, Dopamine; Spiperone; Trifluoperazine | 1982 |
Chronic treatments with zotepine, thioridazine, and haloperidol affect apomorphine-elicited stereotypic behavior and striatal 3H-spiroperidol binding sites in the rat.
Topics: Animals; Antipsychotic Agents; Apomorphine; Binding Sites; Butyrophenones; Corpus Striatum; Dibenzothiepins; Drug Interactions; Haloperidol; Humans; Male; Rats; Rats, Inbred Strains; Spiperone; Stereotyped Behavior; Thioridazine | 1981 |
[3H]N-propylapomorphine and [3H]spiperone binding in brain indicate two states of the D2-dopamine receptor.
Topics: Animals; Antipsychotic Agents; Apomorphine; Brain; Butyrophenones; Catecholamines; Cattle; Caudate Nucleus; Cyclic AMP; Ergot Alkaloids; Guanosine Triphosphate; In Vitro Techniques; Kinetics; Receptors, Dopamine; Spiperone | 1982 |
Neurochemical studies of the mesolimbic dopaminergic pathway: [3H]spiperone labels two bindings sites in homogenates of the nucleus accumbens of rat brain.
Topics: Animals; Antipsychotic Agents; Apomorphine; Butyrophenones; Dopamine; Ergolines; Kinetics; Nucleus Accumbens; Rats; Receptors, Dopamine; Septal Nuclei; Spiperone | 1982 |
Phenoxybenzamine treatment differentiates dopaminergic 3H-ligand binding sites in bovine caudate membranes.
Topics: Animals; Antipsychotic Agents; Apomorphine; Binding, Competitive; Cattle; Caudate Nucleus; In Vitro Techniques; Kinetics; Membranes; Phenoxybenzamine; Pituitary Gland, Anterior; Receptors, Dopamine; Spiperone | 1982 |
Behavioral and radioligand binding evidence for irreversible dopamine receptor blockade by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline.
Topics: Adrenergic alpha-Antagonists; Animals; Apomorphine; Catalepsy; Dose-Response Relationship, Drug; Humans; Injections, Intraperitoneal; Male; Quinolines; Rats; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Time Factors | 1983 |
Characterization of dopamine autoreceptor and [3H]spiperone binding sites in vitro with classical and novel dopamine receptor agonists.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adrenergic alpha-Agonists; Animals; Apomorphine; Benzazepines; Binding Sites; Bromocriptine; Butyrophenones; Cats; Caudate Nucleus; Dopamine; Electric Stimulation; Female; In Vitro Techniques; Male; Phentolamine; Receptors, Dopamine; Spiperone; Sulpiride; Tritium | 1983 |
Long-term adaptive changes in striatal dopamine function in response to chronic neuroleptic intake in rats.
Topics: Acetylcholine; Animals; Antipsychotic Agents; Apomorphine; Corpus Striatum; Glutamates; Glutamic Acid; Haloperidol; Rats; Receptors, Dopamine; Spiperone; Sulpiride | 1983 |
SCH 23390, a potential benzazepine antipsychotic with unique interactions on dopaminergic systems.
Topics: Animals; Antipsychotic Agents; Apomorphine; Benzazepines; Body Temperature; Corpus Striatum; Dopamine; Male; Mice; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1983 |
Changes in apomorphine-induced stereotypy as a result of subacute neuroleptic treatment correlates with increased D-2 receptors, but not with increases in D-1 receptors.
Topics: Animals; Antipsychotic Agents; Apomorphine; Brain; Drug Synergism; Flupenthixol; Haloperidol; Humans; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone; Stereotyped Behavior; Sulpiride; Thioxanthenes | 1983 |
Effects of agonists and antagonists of D1 and D2 dopamine receptors on self-stimulation of the medial prefrontal cortex in the rat.
Topics: Animals; Apomorphine; Bromocriptine; Cerebral Cortex; Dose-Response Relationship, Drug; Ergolines; Functional Laterality; Male; Pimozide; Rats; Rats, Inbred Strains; Receptors, Dopamine; Self Stimulation; Spiperone; Sulpiride; Synaptic Transmission | 1983 |
Dopamine receptor function and spontaneous orofacial dyskinesia in rats during 6-month neuroleptic treatments.
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Dyskinesia, Drug-Induced; Humans; Male; Rats; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1983 |
Elevation of circulating prolactin concentrations may not cause striatal dopamine receptor supersensitivity.
Topics: Animals; Antipsychotic Agents; Apomorphine; Body Weight; Corpus Striatum; Humans; Male; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1983 |
The effect of melanotropin release inhibiting factor, its metabolites and analogs on [3H]spiroperidol and [3H]apomorphine binding sites.
Topics: Animals; Apomorphine; Butyrophenones; Corpus Striatum; Hypothalamus; In Vitro Techniques; Male; Membranes; MSH Release-Inhibiting Hormone; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1983 |
Interaction of the component enantiomers of the putative dopamine autoreceptor agonist, TL-99 (6,7-dihydroxy-2-dimethylamino tetralin) with dopaminergic systems in mammalian brain and teleost retina.
Topics: Adrenergic alpha-Agonists; Animals; Apomorphine; Brain; Female; Fishes; Male; Mice; Motor Activity; Naphthalenes; Rats; Rats, Inbred Strains; Receptors, Dopamine; Retina; Spiperone; Stereoisomerism; Sulpiride; Tetrahydronaphthalenes; Yohimbine | 1983 |
Enhanced striatal 3H-spiroperidol binding induced by chronic haloperidol treatment inhibited by peptides administered during the withdrawal phase.
Topics: Animals; Apomorphine; Butyrophenones; Corpus Striatum; Dipeptides; Haloperidol; Male; Motor Activity; MSH Release-Inhibiting Hormone; Neuropeptides; Peptides, Cyclic; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Time Factors | 1984 |
Studies on the mechanism of action of substituted benzamide drugs.
Topics: Animals; Antipsychotic Agents; Apomorphine; Benzamides; Brain; Catalepsy; Corpus Striatum; Humans; Hyperkinesis; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Substantia Nigra; Sulpiride; Tritium | 1984 |
l-Glutamate reduces the affinity of [3H]N-propylnorapomorphine binding sites in striatal membranes.
Topics: Animals; Antiparkinson Agents; Apomorphine; Aspartic Acid; Binding Sites; Cell Membrane; Corpus Striatum; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Spiperone | 1984 |
Imaging CNS receptors: the dopaminergic system.
Topics: Animals; Antipsychotic Agents; Apomorphine; Binding Sites; Brain; Carbon Radioisotopes; Deoxyglucose; Dyskinesia, Drug-Induced; Fluorine; Haloperidol; Humans; Parkinson Disease; Radioisotopes; Receptors, Dopamine; Schizophrenia; Spiperone; Tomography, Emission-Computed; Tritium | 1984 |
In vivo and in vitro evidence of dopaminergic system down regulation induced by chronic L-DOPA.
Topics: Animals; Apomorphine; Benserazide; Binding Sites; Cell Membrane; Corpus Striatum; Dopamine; Hydrazines; Levodopa; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Tetrahydronaphthalenes; Tyrosine 3-Monooxygenase | 1984 |
Effects of prolyl-leucyl-glycinamide and cyclo(leucyl-glycine) on the supersensitivity of dopamine receptors in brain induced by chronic administration of haloperidol to rats.
Topics: Animals; Apomorphine; Body Weight; Cell Membrane; Corpus Striatum; Dipeptides; Haloperidol; In Vitro Techniques; Male; Motor Activity; MSH Release-Inhibiting Hormone; Neuropeptides; Peptides, Cyclic; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1984 |
Pharmacology of fluperlapine compared with clozapine.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Apomorphine; Binding, Competitive; Brain Chemistry; Clozapine; Dibenzazepines; Dopamine; Electroencephalography; Homovanillic Acid; Humans; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1984 |
Investigation on central dopaminergic receptors (D-2) using the antagonistic properties of new benzamides.
Topics: Animals; Apomorphine; Benzamides; Brain; Corpus Striatum; In Vitro Techniques; Male; Mice; Molecular Conformation; Nortropanes; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Structure-Activity Relationship; Sulpiride | 1984 |
Dopamine receptor binding sites in the rat superior colliculus.
Topics: Animals; Apomorphine; In Vitro Techniques; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Superior Colliculi | 1984 |
Remoxipride, a new potential antipsychotic compound with selective antidopaminergic actions in the rat brain.
Topics: Adenylyl Cyclases; Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Benzamides; Binding, Competitive; Brain Chemistry; Catalepsy; Chlorpromazine; Dogs; Female; Haloperidol; Histocytochemistry; Humans; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Remoxipride; Spiperone; Sulpiride; Thioridazine; Vomiting | 1984 |
Reduced dopaminergic binding during aging in the rodent striatum.
Topics: Aging; Animals; Apomorphine; Binding, Competitive; Butaclamol; Corpus Striatum; Hypothalamus; Male; Mice; Mice, Inbred Strains; Olfactory Bulb; Receptors, Dopamine; Serotonin; Spiperone; Tetrahydronaphthalenes | 1980 |
Retina contains guanine nucleotide sensitive and insensitive classes of dopamine receptors.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Binding Sites; Butaclamol; Cattle; Corpus Striatum; Guanine Nucleotides; Guanosine Triphosphate; Kinetics; Naphthols; Rats; Receptors, Dopamine; Retina; Spiperone; Tetrahydronaphthalenes | 1980 |
Interaction of opiates with dopamine receptors: receptor binding and behavioral assays.
Topics: Animals; Apomorphine; Binding, Competitive; Brain; Butaclamol; Dibenzocycloheptenes; Haloperidol; Kinetics; Male; Methadone; Morphine; Naloxone; Rats; Receptors, Dopamine; Spiperone | 1982 |
Differential labelling of dopamine receptors in rat brain in vivo: comparison of [3H]piribedil, [3H]S 3608 and [3H]N,n-propylnorapomorphine.
Topics: Animals; Apomorphine; Brain; Butaclamol; Corpus Striatum; Female; Nucleus Accumbens; Piperazines; Piribedil; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1983 |
Correspondency between different affinity states and target size of the bovine striatal D2 dopamine receptor.
Topics: Acetylcholinesterase; Animals; Apomorphine; Butaclamol; Cattle; Cell Membrane; Corpus Striatum; Dopamine; Guanosine Triphosphate; Kinetics; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Sulpiride | 1983 |
Differential ontogenesis of D1 and D2 dopaminergic receptors in the chick embryo retina.
Topics: Animals; Apomorphine; Binding, Competitive; Butaclamol; Chick Embryo; Cyclic AMP; Dopamine; Drug Interactions; Receptors, Dopamine; Retina; Spiperone | 1984 |
The effects of denervation and chronic haloperidol treatment on neostriatal dopamine receptor density are not additive in the rat.
Topics: Animals; Apomorphine; Butaclamol; Corpus Striatum; Drug Interactions; Haloperidol; Hydroxydopamines; Male; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Rotation; Spiperone | 1984 |
[3H]spiperone binding in the nigrostriatal system in human brain.
Topics: Aged; Apomorphine; Binding, Competitive; Butaclamol; Butyrophenones; Caudate Nucleus; Cinanserin; Corpus Striatum; Domperidone; Female; Haloperidol; Humans; In Vitro Techniques; Kinetics; Male; Nerve Endings; Phentolamine; Postmortem Changes; Putamen; Spiperone; Substantia Nigra; Sulpiride; Time Factors | 1984 |
High- and low-affinity states of striatal D2 receptors are not affected by 6-hydroxydopamine or chronic haloperidol treatment.
Topics: Animals; Apomorphine; Butaclamol; Cinanserin; Corpus Striatum; Dopamine; Guanylyl Imidodiphosphate; Haloperidol; Hydroxydopamines; Male; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1984 |
Induction of oral dyskinesias in naive rats by D1 stimulation.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Benzazepines; Dyskinesia, Drug-Induced; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone; Sulpiride | 1983 |
Molindone compared to haloperidol in a guinea-pig model of tardive dyskinesia.
Topics: Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dyskinesia, Drug-Induced; Guinea Pigs; Haloperidol; Humans; Indoles; Male; Molindone; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Stereotyped Behavior | 1984 |
Locomotor activity and antinociception after putative mu, kappa and sigma opioid receptor agonists in the rat: influence of dopaminergic agonists and antagonists.
Topics: Analgesics; Animals; Apomorphine; Dopamine; Dopamine Antagonists; Drug Interactions; Male; Motor Activity; Naltrexone; Postural Balance; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma; Spiperone | 1981 |
Neurotransmitter receptors in brain regions of acrylamide- treated rats. I: Effects of a single exposure to acrylamide.
Topics: Acrylamides; Animals; Apomorphine; Corpus Striatum; Humans; Male; Methylmercury Compounds; Proadifen; Rats; Receptors, Dopamine; Receptors, Neurotransmitter; Spiperone; Stereotyped Behavior | 1981 |
Discrimination of functionally heterogeneous receptor subpopulations: antipsychotic and antidopaminergic properties of metoclopramide [proceedings].
Topics: Animals; Apomorphine; Binding Sites; Humans; Metoclopramide; Rats; Receptors, Dopamine; Receptors, Neurotransmitter; Schizophrenia; Spiperone | 1981 |
Recovery of function after mesotelencephalic dopaminergic injury in senescence.
Topics: Aging; Animals; Apomorphine; Corpus Striatum; Dominance, Cerebral; Dopamine; Male; Mesencephalon; Nerve Regeneration; Neuronal Plasticity; Orientation; Rats; Rats, Inbred F344; Receptors, Dopamine; Spiperone; Substantia Nigra; Synaptic Transmission; Telencephalon; Touch | 1983 |
Dopamine receptor profile of co-dergocrine (Hydergine) and its components.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Choline; Corpus Striatum; Cyclic AMP; Dihydroergotoxine; Electric Stimulation; Ergot Alkaloids; Male; Rats; Receptors, Dopamine; Spiperone | 1982 |
Evidence that the D-2 dopamine receptor in the intermediate lobe of the rat pituitary gland is associated with an inhibitory guanyl nucleotide component.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Cholera Toxin; Guanine Nucleotides; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Isoproterenol; Pituitary Gland; Rats; Receptors, Adrenergic, beta; Receptors, Dopamine; Spiperone | 1983 |
Chronic sulpiride increased 3H-spiperone binding and calmodulin dependent phosphorylation in rat striatum.
Topics: Animals; Apomorphine; Butyrophenones; Calcium; Calcium-Binding Proteins; Calmodulin; Corpus Striatum; Cyclic AMP; Humans; Male; Phosphorylation; Rats; Spiperone; Stereotyped Behavior; Sulpiride | 1983 |
Cholecystokinin peptides in vitro modulate the characteristics of the striatal 3H-N-propylnorapomorphine sites.
Topics: Animals; Apomorphine; Cell Membrane; Corpus Striatum; Gastrins; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sincalide; Spiperone; Tetragastrin | 1983 |
Effect of chronic ethanol treatment on adenylate cyclase activity in rat striatum.
Topics: Adenylyl Cyclases; Alcohol Drinking; Animals; Apomorphine; Corpus Striatum; Cyclic AMP; Dopamine; Ethanol; Guanosine Triphosphate; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Synaptic Membranes; Synaptic Transmission | 1983 |
Effects of chronic lithium treatment on dopamine receptors in the rat corpus striatum. I. Locomotor activity and behavioral supersensitivity.
Topics: Animals; Apomorphine; Body Weight; Chlorides; Corpus Striatum; Eating; Haloperidol; Humans; Lithium; Lithium Chloride; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1982 |
Effects of chronic lithium treatment on dopamine receptors in the rat corpus striatum. II. No effect on denervation or neuroleptic-induced supersensitivity.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Chlorides; Corpus Striatum; Dopamine; Haloperidol; Humans; Hydroxydopamines; Kinetics; Lithium; Lithium Chloride; Male; Motor Activity; Neural Pathways; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Substantia Nigra | 1982 |
Role of calmodulin-dependent phosphorylation in chronic sulpiride-induced striatal dopamine receptor supersensitivity.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Calmodulin; Corpus Striatum; Cyclic AMP; Male; Protein Kinases; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Sulpiride | 1984 |
Specific receptor-mediated inhibition of cyclic AMP synthesis by dopamine in a neuroblastoma X brain hybrid cell line NCB-20.
Topics: Alprostadil; Animals; Apomorphine; Brain; Cell Line; Cell Membrane; Clonidine; Cricetinae; Cricetulus; Cyclic AMP; Dopamine; Hybrid Cells; Mice; Neuroblastoma; Prostaglandins E; Receptors, Dopamine; Serotonin; Spiperone | 1984 |
Neurochemical investigations in vitro with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in preparations of rat brain.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Acetylcholine; Adenylyl Cyclases; Animals; Apomorphine; Brain Chemistry; Cerebral Cortex; Choline; Corpus Striatum; Dopamine; Electric Stimulation; In Vitro Techniques; Kinetics; Male; Mitochondria; Monoamine Oxidase; Norepinephrine; Pyridines; Rats; Spiperone | 1984 |
Dopaminergic supersensitivity at distant sites following induced epileptic foci.
Topics: Amygdala; Animals; Apomorphine; Behavior, Animal; Butyrophenones; Chlorides; Epilepsies, Partial; Ferric Compounds; Male; Nucleus Accumbens; Rats; Rats, Inbred Strains; Septal Nuclei; Spiperone | 1983 |
Posture-independent sensorimotor analysis of inter-hemispheric receptor asymmetries in neostriatum.
Topics: Animals; Apomorphine; Brain; Corpus Striatum; Dopamine; Forelimb; Functional Laterality; Hydroxydopamines; Kainic Acid; Male; Motor Activity; Oxidopamine; Posture; Radius; Rats; Receptors, Dopamine; Spiperone; Substantia Nigra; Ulna | 1983 |
Localization of [3H]N-propylnorapomorphine binding in mouse striatum.
Topics: Afferent Pathways; Animals; Apomorphine; Corpus Striatum; Frontal Lobe; Hydroxydopamines; Kainic Acid; Kinetics; Male; Mice; Mice, Inbred C57BL; Neural Pathways; Neurons; Oxidopamine; Receptors, Dopamine; Spiperone | 1983 |
Differential anatomical location of [3H]-N,n-propylnorapomorphine and [3H]-spiperone binding sites in the striatum and substantia nigra of the rat.
Topics: Animals; Apomorphine; Butyrophenones; Corpus Striatum; Female; Hydroxydopamines; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Substantia Nigra; Tritium | 1983 |
The effects of chronic lithium on behavioral and biochemical indices of dopamine receptor supersensitivity in the rat.
Topics: Animals; Apomorphine; Behavior, Animal; Binding, Competitive; Body Temperature; Dextroamphetamine; Drug Interactions; Haloperidol; Humans; Lithium; Male; Motor Activity; Rats; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1984 |
Pharmacologic profile of a novel potent direct-acting dopamine agonist, (+)-4-propyl-9-hydroxynaphthoxazine [(+)-PHNO].
Topics: Adenylyl Cyclases; Animals; Apomorphine; Binding, Competitive; Body Temperature; Brain Stem; Female; Fishes; Humans; Hydroxydopamines; Mice; Motor Activity; Oxazines; Oxidopamine; Posture; Rats; Rats, Inbred Strains; Receptors, Dopamine; Retina; Spiperone; Stereotyped Behavior; Vomiting | 1984 |
Effect of dopamine system activation on substantia nigra pars reticulata output neurons: variable single-unit responses in normal rats and inhibition in 6-hydroxydopamine-lesioned rats.
Topics: Animals; Apomorphine; Dopamine; Efferent Pathways; Flupenthixol; Haloperidol; Hydroxydopamines; Injections, Intravenous; Male; Neural Inhibition; Neurons; Oxidopamine; Rats; Rats, Inbred Strains; Spiperone; Substantia Nigra; Tectum Mesencephali; Thalamus | 1984 |
Differential effects of continuous administration for 1 year of haloperidol or sulpiride on striatal dopamine function in the rat.
Topics: Acetylcholine; Animals; Apomorphine; Body Weight; Corpus Striatum; Haloperidol; Humans; Kinetics; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Sulpiride | 1984 |
Differential alterations in striatal dopamine receptor sensitivity induced by repeated administration of clinically equivalent doses of haloperidol, sulpiride or clozapine in rats.
Topics: Animals; Apomorphine; Clozapine; Corpus Striatum; Dibenzazepines; Haloperidol; Humans; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Sulpiride | 1984 |
Lack of evidence that the central serotoninergic system plays a role in the activation of prolactin secretion following inhibition of dopamine synthesis or blockade of dopamine receptors in the male rat.
Topics: 5-Hydroxytryptophan; Animals; Apomorphine; Cyproheptadine; Depression, Chemical; Dopamine; Dopamine Antagonists; Fenclonine; Fluoxetine; Flupenthixol; Hypothalamus; Male; Methysergide; Prolactin; Rats; Receptors, Dopamine; Receptors, Serotonin; Spiperone; Stimulation, Chemical; Tyrosine | 1980 |
Chronic dihydroergotoxine treatment affects the number of dopamine recognition sites in rat striatum.
Topics: Animals; Antiparkinson Agents; Apomorphine; Butyrophenones; Corpus Striatum; Dihydroergotoxine; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Tritium | 1984 |
Differential effects of chronic clorgyline and amfonelic acid on desensitization of striatal dopamine receptors.
Topics: Animals; Apomorphine; Behavior, Animal; Cerebral Cortex; Clorgyline; Corpus Striatum; Dihydroalprenolol; Haloperidol; Male; Monoamine Oxidase Inhibitors; Nalidixic Acid; Naphthyridines; Propylamines; Rats; Receptors, Dopamine; Spiperone; Thioxanthenes | 1984 |
Similar effect of estradiol and haloperidol on experimental tardive dyskinesia in monkeys.
Topics: Animals; Apomorphine; Drug Interactions; Dyskinesia, Drug-Induced; Estradiol; Female; Haloperidol; Macaca fascicularis; Receptors, Dopamine; Spiperone | 1984 |
Behavioral and biochemical evidence of apomorphine-induced supersensitivity of the striatal dopamine receptors.
Topics: Animals; Apomorphine; Corpus Striatum; Female; Membranes; Mesencephalon; Movement; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Substantia Nigra | 1984 |
Enhancement of hypophysectomy-induced dopamine receptor hypersensitivity in male rats by chronic haloperidol administration.
Topics: Animals; Apomorphine; Brain; Female; Haloperidol; Humans; Hypophysectomy; Kinetics; Male; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1984 |
Alterations in different populations of striatal dopamine receptors produced by 18 months continuous administration of cis- or trans-flupenthixol to rats.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Body Weight; Catalepsy; Corpus Striatum; Flupenthixol; Humans; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereoisomerism; Stereotyped Behavior; Thioxanthenes | 1984 |
[Effect of repeated haloperidol and apomorphine administration on the development of tolerance for catalepsy and dopamine receptor hypersensitivity in mice].
Topics: Animals; Apomorphine; Catalepsy; Corpus Striatum; Dose-Response Relationship, Drug; Drug Synergism; Drug Tolerance; Haloperidol; Humans; Male; Mice; Receptors, Dopamine; Spiperone; Time Factors | 1984 |
Synthesis and dopaminergic activity of 3-(3,4-dihydroxyphenyl)-1-n-propylpyrrolidine hydrobromide.
Topics: Animals; Apomorphine; Behavior, Animal; Catalepsy; Chemical Phenomena; Chemistry; Dopamine; Humans; Prolactin; Pyrrolidines; Rats; Receptors, Dopamine; Spiperone | 1984 |
Turnover of specific [3H]spiperone and [3H]N,n-propylnorapomorphine binding sites in rat striatum following phenoxybenzamine administration.
Topics: Animals; Apomorphine; Binding Sites; Binding, Competitive; Butyrophenones; Corpus Striatum; Female; Kinetics; Phenoxybenzamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1983 |
Responses of pulmonary vasculature of cattle to dopamine and apomorphine.
Topics: Animals; Apomorphine; Cattle; Dopamine; Dose-Response Relationship, Drug; In Vitro Techniques; Propranolol; Pulmonary Artery; Receptors, Dopamine; Spiperone; Vasoconstriction; Vasodilation | 1983 |
Normalization of spiroperidol binding in the denervated rat striatum by homologous grafts of substantia nigra.
Topics: Animals; Apomorphine; Autoradiography; Denervation; Dextroamphetamine; Motor Activity; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Substantia Nigra | 1983 |
[Effect of in vitro serotonin on dopaminergic binding sites in rat striatal membranes].
Topics: Animals; Apomorphine; Binding, Competitive; Corpus Striatum; In Vitro Techniques; Membranes; Methiothepin; Rats; Receptors, Dopamine; Serotonin; Spiperone | 1983 |
Cyclo(Leu-Gly): a possible treatment for tardive dyskinesia?
Topics: Animals; Apomorphine; Corpus Striatum; Dipeptides; Drug Tolerance; Dyskinesia, Drug-Induced; Haloperidol; Male; Mice; Neuropeptides; Peptides, Cyclic; Spiperone | 1983 |
Direct radioligand measurement of dopamine receptors in the anterior pituitary gland.
Topics: Animals; Apomorphine; Binding, Competitive; Cattle; Cell Membrane; Cells, Cultured; Ligands; Pituitary Gland, Anterior; Radioligand Assay; Receptors, Dopamine; Spiperone; Swine; Tritium | 1983 |
Lack of potency of metoclopramide's metabolites in various dopaminergic models.
Topics: Animals; Apomorphine; Dopamine; Fluphenazine; Haloperidol; Homovanillic Acid; Humans; Male; Metoclopramide; Prolactin; Rats; Rats, Inbred Strains; Spiperone; Stereotyped Behavior; Tetrahydronaphthalenes | 1983 |
Interactions of neurotensin with brain dopamine systems: biochemical and behavioral studies.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Brain Chemistry; Dopamine; Drug Interactions; Humans; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Motor Activity; Neurotensin; Rats; Rats, Inbred Strains; Spiperone; Stereotyped Behavior | 1983 |
The effects of dose and duration of chronic pimozide administration on dopamine receptor supersensitivity.
Topics: Animals; Apomorphine; Dextroamphetamine; Dose-Response Relationship, Drug; Humans; Male; Motor Activity; Pimozide; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Time Factors | 1983 |
Persistent increase in striatal dopamine stimulated adenylate cyclase activity persists for more than 6 months but disappears after 1 year following withdrawal from 18 months cis-flupenthixol intake.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Binding Sites; Corpus Striatum; Dopamine; Flupenthixol; Humans; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Thioxanthenes; Time Factors | 1983 |
Psychomotor performance in the senescent rodent: reduction of deficits via striatal dopamine receptor up-regulation.
Topics: Aging; Animals; Apomorphine; Corpus Striatum; Haloperidol; Humans; Motor Skills; Rats; Rats, Inbred F344; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1983 |
Interaction of (+)- and (-)-3-PPP with the dopamine receptor in the anterior pituitary gland.
Topics: Animals; Apomorphine; Binding Sites; Cell Membrane; Depression, Chemical; In Vitro Techniques; Male; Methyltyrosines; Piperidines; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereoisomerism | 1984 |
Increase in serum corticosterone concentration and decrease in hypothalamic epinephrine concentration by N-propylnorapomorphine in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Corticosterone; Epinephrine; Homovanillic Acid; Hypothalamus; Male; Rats; Rats, Inbred Strains; Spiperone | 1984 |
A comparison of striatal and mesolimbic dopamine function in the rat during 6-month trifluoperazine administration.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Binding Sites; Corpus Striatum; Dopamine; Humans; Limbic System; Male; Rats; Spiperone; Stereotyped Behavior; Time Factors; Trifluoperazine | 1980 |
Binding of antiparkinsonian ergot derivatives to the dopamine receptor.
Topics: Animals; Antiparkinson Agents; Apomorphine; Bromocriptine; Caudate Nucleus; Ergolines; Lisuride; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1981 |
Antipodal central effects of apomorphine and dopamine in chickens.
Topics: Animals; Apomorphine; Body Temperature; Brain; Carbon Dioxide; Chickens; Dextroamphetamine; Dopamine; Dopamine Antagonists; Electroencephalography; Hypothalamus; Motor Activity; Spiperone | 1982 |
Behavioral and biochemical aspects of neuroleptic-induced dopaminergic supersensitivity: studies with chronic clozapine and haloperidol.
Topics: Acetylcholine; Animals; Apomorphine; Behavior, Animal; Clozapine; Corpus Striatum; Dibenzazepines; Haloperidol; Humans; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1982 |
Dopamine receptor sensitivity after chronic dopamine agonists. Striatal 3H-spiroperidol binding in mice after chronic administration of high doses of apomorphine, N-n-propylnorapomorphine and dextroamphetamine.
Topics: Animals; Apomorphine; Butyrophenones; Corpus Striatum; Dextroamphetamine; Humans; Male; Mice; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1982 |
A pharmacological comparison of 6,7-dihydroxy-2-dimethylaminotetralin (TL-99) and N-n-propyl-3-(3-hydroxyphenyl)piperidine with (3-PPP) selected dopamine agonists.
Topics: 4-Butyrolactone; Animals; Apomorphine; Cell Membrane; Corpus Striatum; Female; Humans; Hydroxydopamines; Naphthalenes; Oxidopamine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Tetrahydronaphthalenes | 1982 |
The effect of chronic bromocriptine and L-dopa on spiperone binding and apomorphine-induced stereotypy.
Topics: Animals; Apomorphine; Bromocriptine; Butyrophenones; Corpus Striatum; Dose-Response Relationship, Drug; Haloperidol; Humans; Levodopa; Male; Muridae; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1982 |
Regulation of ligand binding to pituitary D-2 dopaminergic receptors. Effects of divalent cations and functional group modification.
Topics: Animals; Apomorphine; Cations, Divalent; Cattle; Dose-Response Relationship, Drug; Ethylmaleimide; Hydroxymercuribenzoates; Kinetics; Male; Pituitary Gland, Anterior; Receptors, Dopamine; Spiperone | 1983 |
Dopamine receptor binding on intact cells. Absence of a high-affinity agonist-receptor binding state.
Topics: Animals; Apomorphine; Binding, Competitive; Cattle; Kinetics; Male; Pituitary Gland, Anterior; Receptors, Dopamine; Spiperone | 1983 |
Excitation by dopamine of putative oxytocinergic neurones in the rat supraoptic nucleus in vitro: evidence for two classes of continuously firing neurones.
Topics: Animals; Apomorphine; Dopamine; Electric Conductivity; Kinetics; Neurons; Oxytocin; Rats; Spiperone; Sulpiride; Supraoptic Nucleus | 1983 |
In vivo interaction of gamma-type endorphins with dopaminergic ligands in rat brain.
Topics: Animals; Apomorphine; beta-Endorphin; Brain; Endorphins; Motor Activity; Peptide Fragments; Rats; Receptors, Dopamine; Spiperone | 1983 |
Interactions of a partial ergoline with dopamine receptors in vivo and in vitro.
Topics: Animals; Apomorphine; Butyrophenones; Cell Membrane; Corpus Striatum; Ergolines; Male; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1983 |
Lack of effects of fibrinogen degradation products on specific binding of [3H]spiroperidol and [3H]ADTN.
Topics: Animals; Apomorphine; Butyrophenones; Dopamine; Fibrin Fibrinogen Degradation Products; In Vitro Techniques; Male; Molecular Weight; Naphthalenes; Rats; Receptors, Dopamine; Spiperone; Tetrahydronaphthalenes | 1983 |
Age alters dopaminergic responses to estradiol.
Topics: Aging; Animals; Apomorphine; Binding, Competitive; Castration; Corpus Striatum; Estradiol; Female; Humans; Rats; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1982 |
Multiple daily amphetamine administration decreases both [3H]agonist and [3H]antagonist dopamine receptor binding.
Topics: Animals; Apomorphine; Butyrophenones; Corpus Striatum; Dextroamphetamine; Dopamine; Humans; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1982 |
Effects of naloxone on d-amphetamine- and apomorphine-induced behavior.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Behavior, Animal; Brain; Dextroamphetamine; Dopamine; Drug Interactions; Humans; Male; Naloxone; Rats; Rats, Inbred Strains; Spiperone; Stereotyped Behavior | 1982 |
Interaction of cholinergic and dopaminergic influences on yawning behavior.
Topics: Animals; Apomorphine; Behavior, Animal; Benzofurans; Citalopram; Fluoxetine; Metergoline; Physostigmine; Propylamines; Rats; Receptors, Cholinergic; Receptors, Dopamine; Scopolamine; Spiperone | 1980 |
Guanine nucleotides regulate both dopaminergic agonist and antagonist binding in porcine anterior pituitary.
Topics: Animals; Apomorphine; Binding, Competitive; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Kinetics; Pituitary Gland, Anterior; Receptors, Dopamine; Spiperone; Swine | 1982 |
Reversal of respiratory responses to dopamine after dopamine antagonists.
Topics: Animals; Apomorphine; Cats; Chlorpromazine; Dopamine; Dopamine Antagonists; Female; Haloperidol; Male; Nitrogen; Oxygen; Perphenazine; Respiration; Spiperone | 1982 |
[3H]spiroperidol identifies a D-2 dopamine receptor inhibiting adenylate cyclase activity in the intermediate lobe of the rat pituitary gland.
Topics: Adenylyl Cyclase Inhibitors; Animals; Apomorphine; Binding, Competitive; Butyrophenones; Cholera Toxin; Fluphenazine; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Male; Pituitary Gland, Posterior; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Sulpiride | 1982 |
Synthesis and dopamine receptor binding of exo- and endo-2-amino-6,7-dihydroxybenzonorbornene, rigid analogues of 2-amino-6,7-dihydroxytetrahydronaphthalene.
Topics: Animals; Apomorphine; Binding, Competitive; Brain; Cattle; Chemical Phenomena; Chemistry; In Vitro Techniques; Male; Molecular Conformation; Norbornanes; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereoisomerism | 1982 |
Guanine nucleotides do not inhibit tritiated dopamine agonist binding to bovine striatal membranes.
Topics: Animals; Apomorphine; Binding, Competitive; Butyrophenones; Cattle; Caudate Nucleus; Corpus Striatum; Dopamine; Guanosine Triphosphate; Receptors, Dopamine; Spiperone; Tetrahydronaphthalenes | 1982 |
Heat treatment mimics guanosine-5'-triphosphate effects on dopaminergic 3H-ligand binding to bovine caudate membranes.
Topics: Animals; Apomorphine; Cattle; Caudate Nucleus; Guanine Nucleotides; Guanosine Triphosphate; Hot Temperature; In Vitro Techniques; Membranes; Receptors, Dopamine; Spiperone | 1982 |
Electrophysiological and behavioral evidence of interaction of dopaminergic and gustatory afferents in the amygdala.
Topics: Afferent Pathways; Amygdala; Animals; Apomorphine; Dopamine; Electric Stimulation; Male; Motor Activity; Neurons; Procaine; Rats; Rats, Inbred Strains; Spiperone; Taste | 1982 |
Dopamine receptor of the porcine anterior pituitary gland. Evidence for two affinity states discriminated by both agonists and antagonists.
Topics: Animals; Apomorphine; Binding Sites; Binding, Competitive; Dopamine; Dopamine Antagonists; Female; Guanine Nucleotides; In Vitro Techniques; Pituitary Gland, Anterior; Receptors, Dopamine; Spiperone; Swine | 1982 |
Dopamine receptor of the porcine anterior pituitary gland. Effects of N-ethylmaleimide and heat on ligand binding mimic the effects of guanine nucleotides.
Topics: Animals; Apomorphine; Ethylmaleimide; Female; Guanine Nucleotides; Hot Temperature; In Vitro Techniques; Pituitary Gland, Anterior; Radioligand Assay; Receptors, Dopamine; Spiperone; Swine | 1982 |
Study on some compensatory responses of dopaminergic system in aging rats.
Topics: Aging; Animals; Apomorphine; Butyrophenones; Corpus Striatum; Feedback; Haloperidol; Homovanillic Acid; Male; Rats; Receptors, Dopamine; Spiperone | 1982 |
Interaction of the putative dopamine autoreceptor agonists 3-PPP and TL-99 with [3H]apomorphine binding sites in rat striatal membranes.
Topics: Animals; Apomorphine; Binding Sites; Binding, Competitive; Corpus Striatum; In Vitro Techniques; Kinetics; Membranes; Naphthalenes; Piperidines; Rats; Receptors, Dopamine; Spiperone; Tetrahydronaphthalenes | 1982 |
Apomorphine-induced stereotypic cage climbing in mice as a model for studying changes in dopamine receptor sensitivity.
Topics: Animals; Apomorphine; Behavior; Humans; Male; Mice; Motor Activity; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1980 |
Estrogen treatment enhances dopamine receptor sensitivity in the rat striatum.
Topics: Amphetamine; Animals; Apomorphine; Corpus Striatum; Estrogens; Humans; Kinetics; Male; Rats; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Time Factors | 1980 |
Increased dopamine receptor sensitivity after estrogen treatment using the rat rotation model.
Topics: Animals; Apomorphine; Corpus Striatum; Dextroamphetamine; Estradiol; Humans; Hydroxydopamines; Male; Rats; Receptors, Dopamine; Rotation; Spiperone; Stereotyped Behavior | 1980 |
Amantadine reduces haloperidol-induced dopamine receptor hypersensitivity in the striatum.
Topics: Amantadine; Animals; Apomorphine; Corpus Striatum; Haloperidol; Humans; In Vitro Techniques; Kinetics; Rats; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1980 |
Changes in cerebral dopamine function induced by a year's administration of trifluoperazine or thioridazine and their subsequent withdrawal.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Brain; Corpus Striatum; Dopamine; Dyskinesia, Drug-Induced; Humans; Male; Rats; Spiperone; Stereotyped Behavior; Substance Withdrawal Syndrome; Thioridazine; Time Factors; Trifluoperazine | 1980 |
Effects of ethanol on central dopamine functions.
Topics: Animals; Apomorphine; Binding Sites; Brain; Corpus Striatum; Dopamine; Ethanol; Humans; Male; Motor Activity; Rats; Spiperone; Stereotyped Behavior | 1980 |
Effect of 3-PPP, a putative dopamine autoreceptor agonist, on rat serum prolactin levels.
Topics: Animals; Apomorphine; Binding, Competitive; Humans; Male; Piperidines; Prolactin; Rats; Receptors, Dopamine; Reserpine; Spiperone; Stereotyped Behavior | 1981 |
Hypophysectomy induced hypersensitivity to dopamine: antagonism by estrogen.
Topics: Animals; Apomorphine; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Estradiol; Female; Haloperidol; Humans; Hypophysectomy; Pituitary Gland; Rats; Rats, Inbred Strains; Spiperone; Stereotyped Behavior | 1981 |
Aging and the regulation of striatal dopaminergic mechanisms in mice.
Topics: Aging; Animals; Apomorphine; Bromocriptine; Corpus Striatum; Haloperidol; Humans; Male; Mice; Mice, Inbred C57BL; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Time Factors | 1981 |
Effects of prenatal treatment of rats with haloperidol due to altered drug distribution in neonatal brain.
Topics: Animals; Animals, Newborn; Apomorphine; Behavior, Animal; Brain; Female; Haloperidol; Humans; Kinetics; Motor Activity; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Spiperone; Stereotyped Behavior | 1981 |
Regional blockade by neuroleptic drugs of in vivo 3H-spiperone binding in the rat brain. Relation to blockade of apomorphine induced hyperactivity and stereotypies.
Topics: Animals; Apomorphine; Binding, Competitive; Brain; Butyrophenones; Chlorpromazine; Clozapine; Haloperidol; Humans; Hyperkinesis; Kinetics; Organ Specificity; Rats; Receptors, Dopamine; Receptors, Drug; Spiperone; Stereotyped Behavior; Sulpiride; Thioridazine | 1981 |
Chronic haloperidol treatment potentiates apomorphine- and ethanol-induced hypothermia in the rat.
Topics: Animals; Apomorphine; Binding Sites; Corpus Striatum; Drug Synergism; Ethanol; Haloperidol; Humans; Hypothermia; Kinetics; Male; Rats; Rats, Inbred Strains; Spiperone; Stereotyped Behavior | 1982 |
Estrogen inhibits the dopaminergic supersensitivity induced by neuroleptics.
Topics: Animals; Apomorphine; Drug Administration Schedule; Estradiol; Female; Haloperidol; Humans; In Vitro Techniques; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1982 |
Effects of Estrogen on Striatal Dopamine receptor function in male and female rats.
Topics: Animals; Apomorphine; Binding, Competitive; Corpus Striatum; Estradiol; Estrogens; Female; Humans; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sex Factors; Spiperone; Stereotyped Behavior | 1982 |
Modification of morphine-induced changes in striatal (3H)-spiroperidol binding and stereotype-behavior by cyclo(Leu-Gly).
Topics: Animals; Apomorphine; Butyrophenones; Corpus Striatum; Dipeptides; Humans; Male; Morphine; Neuropeptides; Peptides, Cyclic; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Time Factors | 1982 |
Septo-hippocampal system: target for substituted benzamides.
Topics: Adenylyl Cyclases; Amphetamine; Animals; Apomorphine; Benzamides; Binding, Competitive; Brain; Corpus Striatum; Hippocampus; Humans; Male; Rats; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1982 |
Dopamine receptors in subcellular fractions from bovine caudate: enrichment of [3H]spiperone binding in a postsynaptic membrane fraction.
Topics: Animals; Apomorphine; Binding, Competitive; Butyrophenones; Cattle; Caudate Nucleus; Dopamine; In Vitro Techniques; Kinetics; Receptors, Dopamine; Spiperone; Subcellular Fractions; Synaptic Membranes | 1981 |
Kainate lesion dissociates striatal dopamine receptor radioligand binding sites.
Topics: Animals; Apomorphine; Benzimidazoles; Corpus Striatum; Domperidone; Flupenthixol; In Vitro Techniques; Kainic Acid; Male; Piperidines; Pyrrolidines; Radioligand Assay; Rats; Receptors, Dopamine; Spiperone | 1981 |
The effect of altered dopaminergic activity on food intake in the rat: evidence for an optimal level of dopaminergic activity for behavior.
Topics: Amphetamine; Amphetamines; Animals; Apomorphine; Brain; Cocaine; Dextroamphetamine; Dopamine; Feeding Behavior; Haloperidol; Levodopa; Methylphenidate; Rats; Spiperone | 1980 |
Dopamine receptor changes following destruction of the nigrostriatal pathway: lack of a relationship to rotational behavior.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Corpus Striatum; Dopamine; Hydroxydopamines; Kinetics; Male; Motor Activity; Movement; Rats; Receptors, Dopamine; Spiperone | 1981 |
D2- but not D3-dopamine receptors detected in the anterior pituitary.
Topics: Animals; Apomorphine; Cattle; Caudate Nucleus; Dopamine; Pituitary Gland, Anterior; Receptors, Dopamine; Spiperone; Tetrahydronaphthalenes | 1981 |
Aporphines, 36. Dopamine receptor interactions of trihydroxyaporphines. Synthesis, radioreceptor binding, and striatal adenylate cyclase stimulation of 2,10,11-trihydroxyaporphines in comparison with other hydroxylated aporphines.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Aporphines; Binding, Competitive; Cattle; Caudate Nucleus; Chemical Phenomena; Chemistry; Corpus Striatum; In Vitro Techniques; Radioligand Assay; Rats; Receptors, Dopamine; Spiperone | 1981 |
Cocaine-induced supersensitivity of striatal dopamine receptors: role of endogenous calmodulin.
Topics: Animals; Apomorphine; Calcium-Binding Proteins; Calmodulin; Cocaine; Corpus Striatum; Dopamine; Enzyme-Linked Immunosorbent Assay; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1981 |
Dopaminergic agonistic and antagonistic drugs in the ventral tegmentum of rats inhibit and facilitate changes of food-search behaviour.
Topics: Animals; Apomorphine; Butyrophenones; Feeding Behavior; Injections, Intraventricular; Rats; Spiperone; Tegmentum Mesencephali | 1981 |
Brain reinforcement mechanisms: alpha-adrenergic and dopaminergic agonists and antagonists.
Topics: Animals; Apomorphine; Brain; Clonidine; Electric Stimulation; Hypothalamus; Locus Coeruleus; Neurons; Phenoxybenzamine; Rats; Receptors, Adrenergic; Receptors, Dopamine; Reinforcement, Psychology; Saimiri; Self Stimulation; Spiperone; Substantia Nigra | 1981 |
An hypothesis of the molecular structure of the dopamine receptor.
Topics: Apomorphine; Chemical Phenomena; Chemistry; Dopamine; Neurotensin; Pimozide; Receptors, Cholinergic; Receptors, Dopamine; Spiperone; Thioridazine | 1981 |
Receptor supersensitivity: relationships to cerebral anatomy and histopathology of schizophrenia.
Topics: Afferent Pathways; Apomorphine; Brain; Corpus Striatum; Gliosis; Haloperidol; Humans; Receptors, Dopamine; Schizophrenia; Spiperone | 1981 |
Biochemical characterization of the dopaminergic innervation of the rat septum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adenylyl Cyclases; Animals; Apomorphine; Dopamine; Endorphins; Enkephalin, Methionine; Enkephalins; Haloperidol; Kinetics; Male; Rats; Receptors, Dopamine; Septum Pellucidum; Spiperone | 1980 |
Phenoxybenzamine discriminates multiple dopamine receptors.
Topics: Animals; Apomorphine; Binding Sites; Cattle; Dopamine; In Vitro Techniques; Ligands; Phenoxybenzamine; Receptors, Dopamine; Spiperone; Tritium | 1980 |
Pseudo non-competitive agonist interactions with dopamine receptors.
Topics: Animals; Apomorphine; Binding Sites; Binding, Competitive; Cattle; Dopamine; Drug Interactions; In Vitro Techniques; Kinetics; Receptors, Dopamine; Spiperone; Tritium | 1980 |
Differentiation by ascorbic acid of dopamine agonist and antagonist binding sites in striatum.
Topics: Animals; Apomorphine; Ascorbic Acid; Corpus Striatum; Dopamine Antagonists; Haloperidol; Male; Naphthols; Oxidation-Reduction; Rats; Receptors, Dopamine; Spiperone; Tetrahydronaphthalenes | 1980 |
Effect of kainic acid on striatal dopamine receptors.
Topics: Animals; Apomorphine; Corpus Striatum; Kainic Acid; Male; Pyrrolidines; Rats; Receptors, Dopamine; Spiperone | 1980 |
Chronic treatment with metoclopramide induces behavioral supersensitivity to apomorphine and enhances specific binding of 3H-spiroperidol to rat striata.
Topics: Animals; Apomorphine; Behavior, Animal; Binding, Competitive; Body Weight; Butyrophenones; Corpus Striatum; Male; Metoclopramide; Rats; Spiperone; Time Factors | 1980 |
Dopamine receptor binding in bovine intermediate lobe pituitary membranes.
Topics: Animals; Apomorphine; Butyrophenones; Catecholamines; Cattle; Cell Membrane; Guanosine Triphosphate; Phenothiazines; Pituitary Gland; Receptors, Dopamine; Spiperone | 1980 |
Optimal conditions for [3H]apomorphine binding and anomalous equilibrium binding of [3H]apomorphine and [3H]spiperone to rat striatal membranes: involvement of surface phenomena versus multiple binding sites.
Topics: Animals; Apomorphine; Butyrophenones; Cell Membrane; Chelating Agents; Corpus Striatum; Female; Hydrogen-Ion Concentration; Kinetics; Postural Balance; Rats; Receptors, Dopamine; Spiperone; Stereoisomerism; Temperature | 1981 |
The D2 dopamine receptor mediates inhibition of growth in GH4ZR7 cells: involvement of protein kinase-C epsilon.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Alprenolol; Animals; Apomorphine; Benzazepines; Butaclamol; Carcinogens; Cell Division; Cell Line; DNA; Dopamine; Ergolines; Humans; Isoenzymes; Kinetics; Norepinephrine; Pertussis Toxin; Phorbol Esters; Pituitary Neoplasms; Protein Kinase C; Quinpirole; Receptors, Dopamine D2; Salicylamides; Spiperone; Thymidine; Transfection; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1994 |
Intrastriatal dopamine infusion reverses compensatory increases in D2-dopamine receptors in the 6-OHDA lesioned rat.
Topics: Animals; Apomorphine; Autoradiography; Corpus Striatum; Dopamine; Functional Laterality; Infusion Pumps, Implantable; Male; Oxidopamine; Radioligand Assay; Rats; Receptors, Dopamine D2; Receptors, GABA-A; Rotation; Spiperone; Substantia Nigra; Up-Regulation | 1995 |
7-(4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyloxy)-3,4-dihydro-2(1H)-quinolinone (OPC-14597), a new putative antipsychotic drug with both presynaptic dopamine autoreceptor agonistic activity and postsynaptic D2 receptor antagonistic activity.
Topics: 4-Butyrolactone; Animals; Antipsychotic Agents; Apomorphine; Aripiprazole; Catalepsy; Corpus Striatum; Dihydroxyphenylalanine; Dopamine Agonists; Dopamine D2 Receptor Antagonists; Drug Interactions; Male; Mice; Mice, Inbred ICR; Motor Activity; Oxidopamine; Piperazines; Presynaptic Terminals; Quinolones; Radioligand Assay; Rats; Reserpine; Spiperone; Stereotyped Behavior; Synapses; Tritium | 1995 |
Behavioral and biochemical changes after bilateral electrolytic lesions of the red nucleus of rat.
Topics: Animals; Apomorphine; Azepines; Behavior, Animal; Body Temperature; Brain Chemistry; Catalepsy; Dopamine; Dopamine Agonists; Haloperidol; Male; Rats; Rats, Wistar; Red Nucleus; Serotonin; Spiperone; Stereotyped Behavior | 1995 |
Alternative splicing of the dopamine D2 receptor directs specificity of coupling to G-proteins.
Topics: Adenylyl Cyclase Inhibitors; Alternative Splicing; Amino Acid Sequence; Animals; Apomorphine; Base Sequence; Cell Line; Cloning, Molecular; Cyclic AMP; Dopamine; Dopamine Agonists; GTP-Binding Proteins; Humans; Isoproterenol; Kinetics; Mice; Molecular Sequence Data; Mutagenesis, Insertional; Receptors, Adrenergic, beta-2; Receptors, Dopamine D2; Recombinant Proteins; Spiperone; Transfection | 1995 |
Modulation of the clozapine structure increases its selectivity for the dopamine D4 receptor.
Topics: Apomorphine; Binding, Competitive; Cells, Cultured; Clozapine; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Humans; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D4; Spiperone; Structure-Activity Relationship | 1995 |
Dopamine D3 receptor antisense influences dopamine synthesis in rat brain.
Topics: Animals; Antisense Elements (Genetics); Apomorphine; Brain; Dopamine; Male; Nucleus Accumbens; Oligonucleotides, Antisense; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Research Design; Spiperone; Substantia Nigra | 1995 |
Chronic neonatal blockade of N-methyl-D-aspartate receptor by CGP 39551 increases dopaminergic function in adult rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Apomorphine; Behavior, Animal; Corpus Striatum; Dopamine; Dopamine Agonists; Ergolines; Motor Activity; Quinpirole; Rats; Rats, Wistar; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate; Spiperone; Stereotyped Behavior; Time Factors | 1994 |
Dopamine D2 receptor agonists: an analysis of indirect models.
Topics: Animals; Apomorphine; Binding, Competitive; Cattle; Dopamine Agents; In Vitro Techniques; Models, Chemical; Molecular Conformation; Neostriatum; Receptors, Dopamine D2; Spiperone | 1994 |
Modulation by estradiol and progesterone of the GTP effect on striatal D-2 dopamine receptors.
Topics: Animals; Apomorphine; Binding, Competitive; Corpus Striatum; Dopamine; Dopamine Agents; Estradiol; Female; Guanosine Triphosphate; In Vitro Techniques; Male; Ovariectomy; Progesterone; Rats; Receptors, Dopamine D2; Spiperone | 1993 |
Convergent regulation by ciliary neurotrophic factor and dopamine of tyrosine hydroxylase expression in cultures of rat substantia nigra.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Benzazepines; Cells, Cultured; Ciliary Neurotrophic Factor; Dopamine; Dose-Response Relationship, Drug; Embryo, Mammalian; Ergolines; Glial Fibrillary Acidic Protein; Haloperidol; Kinetics; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Neurotransmitter Agents; Phosphopyruvate Hydratase; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Recombinant Proteins; Spiperone; Substantia Nigra; Sulpiride; Time Factors; Tyrosine 3-Monooxygenase | 1993 |
Synthesis and in vivo distribution in the rat of a dopamine agonist: N-([11C]methyl)norapomorphine.
Topics: Animals; Apomorphine; Brain; Carbon Radioisotopes; Dopamine Agents; Kidney; Liver; Lung; Male; Raclopride; Rats; Rats, Wistar; Receptors, Dopamine D2; Salicylamides; Spiperone | 1993 |
Adrenal medulla grafts in the hemiparkinsonian rat: profile of behavioral recovery predicts restoration of the symmetry between the two striata in measures of pre- and postsynaptic dopamine function.
Topics: Adrenal Medulla; Amphetamine; Animals; Apomorphine; Benzazepines; Cerebral Ventricles; Corpus Striatum; Denervation; Female; Functional Laterality; In Situ Hybridization; Motor Activity; Oxidopamine; Parkinson Disease, Secondary; Rats; Receptors, Dopamine D2; RNA, Messenger; Rotation; Spiperone; Substantia Nigra; Transplantation, Heterotopic; Tyrosine 3-Monooxygenase | 1993 |
Monoamine oxidase inhibitors inhibit [3H]quinpirole binding in rat striatal membranes.
Topics: Animals; Apomorphine; Binding, Competitive; Corpus Striatum; Dopamine Agents; Ergolines; In Vitro Techniques; Kinetics; Male; Membranes; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenazocine; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, sigma; Spiperone | 1993 |
Effects of apomorphine on sexual behavior in male quail.
Topics: Animals; Apomorphine; Coturnix; Depression, Chemical; Dopamine; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Male; Pimozide; Sexual Behavior, Animal; Spiperone | 1994 |
The dopamine D3-receptor: a postsynaptic receptor inhibitory on rat locomotor activity.
Topics: Aminoquinolines; Animals; Apomorphine; CHO Cells; Corpus Striatum; Cricetinae; Dextroamphetamine; Dopamine; Dopamine Antagonists; Drug Interactions; Indans; Male; Methyltyrosines; Models, Biological; Motor Activity; Nucleus Accumbens; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Recombinant Fusion Proteins; Reserpine; Salicylamides; Spiperone; Stimulation, Chemical | 1993 |
Specific induction of a functional endogenous D2 short dopamine receptor in GH4C1 cells.
Topics: Animals; Apomorphine; Base Sequence; Colforsin; Cyclic AMP; Dopamine; Dose-Response Relationship, Drug; Ergolines; Gene Expression; Kanamycin Kinase; Kinetics; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphotransferases; Pituitary Neoplasms; Polymerase Chain Reaction; Potassium Chloride; Prolactin; Quinpirole; Rats; Receptors, Dopamine D2; Recombinant Fusion Proteins; Spiperone; Sulpiride; Transfection; Tumor Cells, Cultured; Vasoactive Intestinal Peptide | 1993 |
Interaction of AZA analogs of chlorpromazine with the dopamine D2 receptor.
Topics: Acetylcholine; Animals; Apomorphine; Aza Compounds; Binding, Competitive; Chlorpromazine; Corpus Striatum; In Vitro Techniques; Male; Mice; Potassium; Quaternary Ammonium Compounds; Receptors, Dopamine D2; Spiperone | 1993 |
Structure-activity relationships of a series of novel (piperazinylbutyl)thiazolidinone antipsychotic agents related to 3-[4-[4-(6-fluorobenzo[b]thien-3-yl)-1-piperazinyl]butyl]-2,5,5- trimethyl-4-thiazolidinone maleate.
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Binding, Competitive; Cell Line; CHO Cells; Cricetinae; Humans; Male; Molecular Structure; Motor Activity; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D4; Receptors, Serotonin; Spiperone; Spiro Compounds; Stereotyped Behavior; Structure-Activity Relationship; Thiazoles; Thiazolidines | 1996 |
In vivo reconstitution of dopamine D2S receptor-mediated G protein activation in baculovirus-infected insect cells: preferred coupling to Gi1 versus Gi2.
Topics: Adenosine Triphosphate; Animals; Apomorphine; Baculoviridae; Binding, Competitive; Cell Line; Colforsin; Cyclic AMP; Dopamine Agonists; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Humans; Receptors, Dopamine D2; Spiperone; Spodoptera | 1996 |
Amphetamine induces hypermotility in MPTP-lesioned mice.
Topics: Animals; Apomorphine; Cell Membrane; Corpus Striatum; Dextroamphetamine; Dopamine Agents; Dopamine Antagonists; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Motor Activity; MPTP Poisoning; Receptors, Dopamine D2; Spiperone; Stereotyped Behavior; Substantia Nigra; Tyrosine 3-Monooxygenase | 1997 |
Perinatal asphyxia induces long-term changes in dopamine D1, D2, and D3 receptor binding in the rat brain.
Topics: Animals; Apomorphine; Asphyxia Neonatorum; Benzazepines; Brain; Cesarean Section; Dopamine Agonists; Female; Humans; Infant, Newborn; Iodine Radioisotopes; Organ Specificity; Pregnancy; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; Spiperone; Sulpiride | 1997 |
GTP regulation of (-)-stepholidine binding to R(H) of D1 dopamine receptors in calf striatum.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Benzazepines; Berberine; Binding, Competitive; Cattle; Corpus Striatum; Guanosine Triphosphate; Male; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Rotation; Spiperone | 1997 |
Antisense knockdown of brain dopamine receptors.
Topics: Animals; Apomorphine; Base Sequence; Benzazepines; Brain; Dopamine; Dopamine Agonists; Male; Neurons; Oligonucleotides, Antisense; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; RNA, Messenger; Spiperone; Tetrahydronaphthalenes | 1998 |
Alterations of striatal cholinergic receptors after lesioning of the substantia nigra.
Topics: Animals; Apomorphine; Cell Membrane; Corpus Striatum; Dopamine Agonists; Dopamine Antagonists; Electrosurgery; Male; Motor Activity; Muscarinic Antagonists; Quinuclidinyl Benzilate; Rats; Receptors, Cholinergic; Receptors, Dopamine; Spiperone; Substantia Nigra | 1998 |
Synthesis and preliminary pharmacological investigations of 1-(1,2-dihydro-2-acenaphthylenyl)piperazine derivatives as potential atypical antipsychotic agents in mice.
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Binding, Competitive; Brain Chemistry; Catalepsy; Chemical Phenomena; Chemistry, Physical; Dopamine Agonists; Dopamine Antagonists; Haloperidol; Mice; Naphthalenes; Piperazines; Rats; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D2; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Spiperone; Stereotyped Behavior | 1999 |
Enhanced striatal dopamine D(2) receptor-induced [35S]GTPgammaS binding after haloperidol treatment.
Topics: Animals; Apomorphine; Binding, Competitive; Catalepsy; Corpus Striatum; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Male; Rats; Rats, Wistar; Receptors, Dopamine D2; Spiperone; Sulfur Radioisotopes; Tritium; Up-Regulation | 1999 |
Reconstitution of functional dopamine D(2s) receptor by co-expression of amino- and carboxyl-terminal receptor fragments.
Topics: Animals; Apomorphine; Binding, Competitive; Clozapine; Colforsin; COS Cells; Cyclic AMP; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Gene Expression; Haloperidol; Membranes; Peptide Fragments; Pergolide; Quinpirole; Radioligand Assay; Rats; Receptors, Dopamine D2; Recombinant Fusion Proteins; Spiperone; Transfection; Tritium | 2000 |
Distinct functions of the two isoforms of dopamine D2 receptors.
Topics: Animals; Apomorphine; Benzazepines; Catalepsy; Chimera; Dopamine; Dopamine Agonists; Dopamine Antagonists; Haloperidol; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutagenesis; Protein Isoforms; Quinpirole; Receptors, Dopamine D2; Signal Transduction; Spiperone; Synapses | 2000 |
Mechanisms of inverse agonism of antipsychotic drugs at the D(2) dopamine receptor: use of a mutant D(2) dopamine receptor that adopts the activated conformation.
Topics: 1-Methyl-3-isobutylxanthine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Apomorphine; Binding, Competitive; Bromocriptine; Butaclamol; Chlorpromazine; CHO Cells; Clozapine; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; GTP-Binding Proteins; Haloperidol; Humans; Macromolecular Substances; Mutagenesis, Site-Directed; Phenethylamines; Piperidines; Protein Binding; Protein Conformation; Radioligand Assay; Receptors, Dopamine D2; Recombinant Fusion Proteins; Sodium; Spiperone; Structure-Activity Relationship; Sulpiride; Transfection; Tyramine | 2001 |
New 1-aryl-4-(biarylmethylene)piperazines as potential atypical antipsychotics sharing dopamine D(2)-receptor and serotonin 5-HT(1A)-receptor affinities.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Benzoxazoles; Dopamine Antagonists; Drug Design; Drug Evaluation, Preclinical; Mice; Piperazines; Rats; Receptors, Dopamine D2; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Spiperone; Structure-Activity Relationship | 2001 |
[A study on the mechanism of apomorphine for treatment of myopia].
Topics: Animals; Apomorphine; Benzazepines; Chickens; Myopia; Receptors, Dopamine D1; Receptors, Dopamine D2; Refraction, Ocular; Spiperone | 1998 |
Synthesis and structure-activity relationship of the isoindolinyl benzisoxazolpiperidines as potent, selective, and orally active human dopamine D4 receptor antagonists.
Topics: Administration, Oral; Animals; Apomorphine; Benzyl Compounds; Dizocilpine Maleate; Dopamine D2 Receptor Antagonists; Indoles; Infusions, Parenteral; Isoxazoles; Piperidines; Prazosin; Rats; Receptors, Dopamine D4; Serine; Spiperone; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity | 2002 |
Apomorphine induces trophic factors that support fetal rat mesencephalic dopaminergic neurons in cultures.
Topics: Animals; Apomorphine; Benzazepines; Brain-Derived Neurotrophic Factor; Cell Count; Cell Culture Techniques; Dopamine; Dopamine Agonists; Dopamine Antagonists; Enzyme-Linked Immunosorbent Assay; Glial Cell Line-Derived Neurotrophic Factor; Haloperidol; Mesencephalon; Nerve Growth Factors; Neurons; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spiperone; Tyrosine 3-Monooxygenase | 2002 |
CCK2 receptor-deficient mice have increased sensitivity of dopamine D2 receptors.
Topics: Animals; Apomorphine; Cerebral Cortex; Dopamine Agonists; Electrophysiology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Radioligand Assay; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Receptors, Dopamine D2; Spiperone; Synaptic Transmission | 2003 |
Interaction of the D2short dopamine receptor with G proteins: analysis of receptor/G protein selectivity.
Topics: Animals; Apomorphine; Binding Sites; Cells, Cultured; Dopamine Agonists; Dopamine Antagonists; Drug Interactions; GTP-Binding Proteins; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Receptors, Dopamine D2; Spiperone; Spodoptera; Sulfur Radioisotopes; Suramin; Tritium | 2003 |
Pharmacological analysis of a dopamine D(2Short):G(alphao) fusion protein expressed in Sf9 cells.
Topics: Animals; Apomorphine; Baculoviridae; Binding Sites; Binding, Competitive; Cell Line; Dopamine Agonists; Dopamine Antagonists; Drug Interactions; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Receptors, Dopamine D2; Recombinant Fusion Proteins; Spiperone; Spodoptera | 2003 |
Axonal degeneration and progressive neurologic disability in multiple sclerosis.
Topics: Animals; Apomorphine; Behavior, Animal; Benzazepines; Binding, Competitive; Catalepsy; Dopamine Agonists; Dopamine Antagonists; Isoquinolines; Male; Mice; Mice, Inbred C57BL; Motor Activity; Neurotoxins; Receptors, Dopamine D1; Spiperone; Tetrahydroisoquinolines | 2003 |
Investigation of the mechanism of agonist and inverse agonist action at D2 dopamine receptors.
Topics: Animals; Apomorphine; Binding, Competitive; Butaclamol; CHO Cells; Cricetinae; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Receptors, Dopamine D2; Spiperone; Sulfur Radioisotopes; Tritium | 2004 |
Biphasic firing response of nucleus accumbens neurons elicited by THPB-18 and its correlation with DA receptor subtypes.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Benzazepines; Berberine Alkaloids; Dopamine D2 Receptor Antagonists; Male; Neurons; Nucleus Accumbens; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone; Ventral Tegmental Area | 2004 |
Effects of long-term biogenic amine transporter blockade on receptor/G-protein coupling in rat brain.
Topics: Animals; Apomorphine; Biogenic Monoamines; Brain; Cocaine; Dopamine Antagonists; Drug Administration Schedule; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Isotopes; Male; Membrane Transport Modulators; Membrane Transport Proteins; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Spiperone; Time | 2005 |
Naloxone-blocked depriming effect of anxiolytic selank on apomorphine-induced behavioral manifestations of hyperfunction of dopamine system.
Topics: Animals; Anti-Anxiety Agents; Apomorphine; Behavior, Animal; Benzodiazepines; Dopamine; Enkephalin, Leucine-2-Alanine; Male; Mice; Naloxone; Olanzapine; Oligopeptides; Receptors, Dopamine D2; Receptors, Opioid, mu; Spiperone; Stereotyped Behavior | 2006 |
Dopamine receptors in the anterior insular cortex modulate long-term nociception in the rat.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Afferent Pathways; Animals; Apomorphine; Benzazepines; Cerebral Cortex; Chronic Disease; Dopamine; Dopamine Agonists; Dopamine Antagonists; Hot Temperature; Male; Microinjections; Models, Neurological; Neuralgia; Nociceptors; Pain; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Sciatic Neuropathy; Self Mutilation; Spiperone | 2008 |
Food restriction markedly increases dopamine D2 receptor (D2R) in a rat model of obesity as assessed with in-vivo muPET imaging ([11C] raclopride) and in-vitro ([3H] spiperone) autoradiography.
Topics: Age Factors; Animals; Apomorphine; Appetite Regulation; Autoradiography; Brain; Disease Models, Animal; Dopamine; Dopamine Agonists; Eating; Food Deprivation; In Vitro Techniques; Male; Motor Activity; Obesity; Positron-Emission Tomography; Raclopride; Rats; Rats, Zucker; Receptors, Dopamine D2; Receptors, Leptin; Spiperone; Tritium | 2008 |
Characterization of functional roles of DRY motif in the 2nd intracellular loop of dopamine D2 and D3 receptors.
Topics: Amino Acid Motifs; Apomorphine; Arginine; Aspartic Acid; Cell Line; Cell Membrane; Cyclic AMP; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Humans; Mutation; Protein Conformation; Protein Structure, Tertiary; Protein Transport; Quinpirole; Receptors, Dopamine D2; Receptors, Dopamine D3; Signal Transduction; Spiperone; Sulpiride; Transfection | 2008 |
Dopamine beta-hydroxylase-deficient mice have normal densities of D(2) dopamine receptors in the high-affinity state based on in vivo PET imaging and in vitro radioligand binding.
Topics: Animals; Apomorphine; Binding, Competitive; Cerebellum; Dopamine Agonists; Dopamine beta-Hydroxylase; Female; Kinetics; Male; Mice; Mice, Knockout; Neostriatum; Positron-Emission Tomography; Radioligand Assay; Radiopharmaceuticals; Receptors, Dopamine D2; Spiperone | 2010 |