apomorphine has been researched along with piperidines in 196 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 116 (59.18) | 18.7374 |
| 1990's | 39 (19.90) | 18.2507 |
| 2000's | 29 (14.80) | 29.6817 |
| 2010's | 12 (6.12) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Janssen, PA; Niemegeers, CJ; Schellekens, KH; Van Bever, WF | 1 |
| Colombo, M; Moragues, J; Prieto, J; Roberts, DJ; Salazar, W; Spickett, RG; Vega, A | 1 |
| Kamei, C; Oka, M; Shimizu, M; Yamada, K; Yoshida, K | 1 |
| Corsini, GU; Del Zompo, M; Gessa, GL; Mangoni, A | 1 |
| Bression, D; Martres, MP; Peillon, F | 1 |
| Iversen, SD; Morgan, MJ; Robbins, TW; Sahakian, BJ | 1 |
| Broekaert, A | 1 |
| Baudry, M; Martres, MP; Schwartz, JC | 1 |
| Lefebvre, RA; Willems, JL | 2 |
| Beckett, PR; Berga, P; Roberts, DJ | 1 |
| Dlabac, A; Metys, J | 1 |
| Annunziato, LA; Moore, KE; Wuerthele, SM | 1 |
| Costentin, J; de la Baume, S; Marçais, H; Patey, G; Protais, P; Schwartz, JC | 1 |
| Boeck, V; Christensen, AV; Danneskiold-Samsoe, P; Hyttel, J; Langeland, J; Nielsen, IM; Pedersen, V; Svendsen, O | 1 |
| Colombo, M; Llupia, J; Roberts, DJ; Salazar, W | 1 |
| Chung, PM; Lee, HK; Wang, SC | 1 |
| Dlavac, A; Kazdová, E; Metys, J | 1 |
| Ishida, R; Ito, K; Kowa, Y; Nurimoto, S; Shintomi, K; Yamamura, M | 1 |
| Shintomi, K; Yamamura, M | 1 |
| Janssen, PA; Lenaerts, FM; Niemegeers, CJ; Schellekens, KH; Wauquier, A | 1 |
| Hudzik, TJ | 1 |
| Bohmaker, K; Bordi, F; Meller, E | 1 |
| Ekman, A; Eriksson, E | 1 |
| Fukamauchi, F; Shibuya, H; Yoshikawa, T | 1 |
| Cook, L; Rohrbach, KW; Tam, SW | 1 |
| Awouters, FH; Janssen, PA; Meert, TF; Megens, AA; Niemegeers, CJ; Schellekens, KH | 1 |
| Aizenstein, ML; De Lucia, R; Planeta, Cda S; Scavone, C | 1 |
| Humphreys, TM; Schmidt, CJ; Sorensen, SM; Taylor, VL | 1 |
| Kruk, ZL; Millar, J; Stamford, JA | 1 |
| Carlsson, A; Kujacic, M; Löfberg, L; Svensson, K | 1 |
| Engberg, G; Wikström, H | 1 |
| Code, RA; Tang, AH | 1 |
| Awouters, F; Janssen, PA; Megens, AA; Niemegeers, CJ | 1 |
| Awouters, FH; Megens, AA; Niemegeers, CJ | 1 |
| Fink, H; Morgenstern, R; Ott, T; Schremmer, C | 1 |
| Svensson, L | 1 |
| Backus, LI; Grahame-Smith, DG; Sharp, T | 1 |
| Awouters, F; Janssen, PA; Meert, TF; Megens, AA; Niemegeers, CJ; Schellekens, KH | 1 |
| Grenhoff, J; Svensson, TH; Ugedo, L | 1 |
| Bowen, WD; de Costa, BR; Hellewell, SB; Jacobson, AE; Rice, KC; Thurkauf, A; Walker, JM | 1 |
| Fico, TA; Spoerlein, MT; Vanderwende, C; Wilmot, CA | 1 |
| Bagetta, G; de Sarro, GB; Marra, R; Nisticò, G; Priolo, E | 1 |
| Claustre, Y; Fage, D; Scatton, B; Zivkovic, B | 1 |
| Sethy, VH; Wenger, D | 1 |
| Carlsson, A; Clark, D; Hjorth, S | 2 |
| Andersson, M; Fowler, CJ; Magnusson, O; Thorell, G | 1 |
| Carnoy, P; Puech, AJ; Simon, P; Soubrie, P | 1 |
| Goiny, M; Uvnäs-Moberg, K | 1 |
| Nichols, NF; Schreur, PJ | 1 |
| Jenner, P; Kelly, E; Marsden, CD | 2 |
| Gerhards, HJ; Henning, R; Lattrell, R; Leven, M | 1 |
| Bohmaker, K; Friedhoff, AJ; Goldstein, M; Meller, E; Namba, Y | 1 |
| Aihara, H; Hashimoto, S; Okuyama, S | 1 |
| Nowak, G; Pawłowski, L | 1 |
| Bagetta, G; Nistico, G; Priolo, E | 1 |
| al-Rashood, KA; Alhaider, AA; el-Obeid, HA; Ginawi, OT; Madani, AA; Mustafa, AA | 1 |
| Arnt, J | 1 |
| Skolnick, P; Weissman, BA; Youdim, MB | 1 |
| Forler, C; Fozard, JR; Middlemiss, DN; Tricklebank, MD | 1 |
| Bergstrom, DA; Carlson, JH; Walters, JR | 1 |
| Bagetta, G; De Sarro, G; Nisticò, G; Priolo, E | 1 |
| Hiyama, T; Kikuchi, T; Suzuki, S; Tsutsui, M; Yamada, K; Yasuda, Y | 1 |
| Altar, CA; Gerber, R; Hall, NR; Liebman, JM | 1 |
| Grigoriadis, D; Seeman, P | 1 |
| Christoffersen, CL; Meltzer, LT | 1 |
| Di Chiara, G; Frau, R; Imperato, A; Tanda, G | 1 |
| Berendsen, HH; Broekkamp, CL | 1 |
| Argiolas, A; Gessa, GL; Melis, MR | 1 |
| Ahlenius, S; Criborn, CO; Henriksson, C; Hillegaart, V | 1 |
| de Chaffoy de Courcelles, D; Leysen, JE; Niemegeers, CJ; Van Gompel, P | 1 |
| Bergstrom, DA; Bromley, SD; Carlson, JH; Jackson, DM; Walters, JR | 1 |
| Baldessarini, RJ; Froimowitz, M; Neumeyer, JL | 1 |
| Andersson, B; Eriksson, E; Hjorth, S | 1 |
| Cook, L; Steinfels, GF; Tam, SW | 1 |
| Broekkamp, CL; Gower, AJ | 1 |
| Carlsson, A; Clark, D; Hjorth, S; Sanchez, D; Svensson, K | 1 |
| Bourat, G; Ducrot, R; Fournel, J; Garret, C; Julou, L | 1 |
| Hasselager, E; Scheel-Krüger, J | 1 |
| Gylys, JA; Holmes, SW | 1 |
| Willems, JL | 1 |
| Fog, R | 1 |
| Andén, NE; Bédard, P | 1 |
| Honma, T; Inaba, S; Kitagawa, S; Ono, K; Sasajima, K; Yamamoto, H | 1 |
| Wurtman, RJ; Yehuda, S | 1 |
| Burghard, GL; Flanagan, TL; Green, H; Kaiser, C; Lester, BM; Swagzdis, JE; Zirkle, CL | 1 |
| Koch, MH | 1 |
| Cotzias, GC; Düby, S; Ginos, JZ; Papavasiliou, PS; Steck, A | 1 |
| Kasé, Y; Nakanishi, M; Okada, T; Tsumagari, T | 1 |
| Dhawan, BN; Gupta, GP | 1 |
| Ennis, C; Gaskin, M; Robbins, TW; Watson, BA | 1 |
| Bendesky, RJ; Jones, JH; Martin, GE | 1 |
| Bacopoulos, NG; Koch, SW; Koe, BK | 1 |
| Boissard, CG; Delini-Stula, A; Mogilnicka, E | 1 |
| Appel, JB; Callahan, PM; Cunningham, KA | 1 |
| Palacios, JM; Wiederhold, KH | 1 |
| Angeby, K; Fuxe, K; Köhler, C; Ogren, SO | 1 |
| Dandiya, PC; Gurbani, NK; Hrishi Keshavan, HJ | 1 |
| Billingsley, ML; Roth, RH | 1 |
| Allikmets, LKh; Maĭmets, MO; Nurk, AM; Riago, LK; Vasar, EE | 1 |
| Carlsson, A; Hjorth, S; Jackson, D; Lindberg, P | 1 |
| Arvidsson, LE; Carlsson, A; Clark, D; Hacksell, U; Hjorth, S; Johansson, A; Lindberg, P; Sanchez, D; Svensson, K; Wikström, H | 1 |
| Carlsson, A | 1 |
| Arnt, J; Hyttel, J | 1 |
| Fenton, HM; Gerhardt, S; Leszczak, E; Liebman, JM | 1 |
| Fink, H; Gold, R; Morgenstern, R | 1 |
| Berendsen, HG; Broekkamp, CL; Gower, AJ; Princen, MM | 1 |
| Ahlenius, S; Larsson, K | 1 |
| Arvidsson, LE; Carlsson, A; Clark, D; Hacksell, U; Hjorth, S; Johansson, A; Lindberg, P; Nilsson, JL; Sanchez, D; Svensson, K; Wikström, H | 1 |
| Adelung, C; Lang, JD; Späth, L; Starke, K | 1 |
| Gudelsky, GA; Meltzer, HY; Simonovic, M | 1 |
| Geyer, MA; Lee, EH | 1 |
| Gudelsky, GA; Meltzer, HY; Mikuni, M; Simonovic, M | 1 |
| Fratta, W; Gessa, GL; Napoli-Farris, L | 1 |
| Ståhle, L; Ungerstedt, U | 1 |
| Heym, J; Jacobs, BL; Rasmussen, K | 1 |
| Arvidsson, LE; Carlsson, A; Hacksell, U; Hjorth, S; Lindberg, P; Nilsson, JL; Sanchez, D; Svensson, U; Wikström, H | 1 |
| Haubrich, DR; Martin, GE; Williams, M | 2 |
| Waldmeier, PC | 1 |
| Ehrlein, HJ | 1 |
| Totaro, JA; Williams, M | 1 |
| Meltzer, HY; Simonovic, M | 1 |
| Martres, MP; Schwartz, JC; Sokoloff, P | 2 |
| Adams, L; Creese, I; Hyttel, J; Leff, S | 1 |
| Boismare, F; Moore, N; Raoult, JP; Saligaut, C | 1 |
| Bogaert, MG; Buylaert, W; Willems, JL | 1 |
| Arca, P; Corsini, GU; Del Zompo, M; Gessa, GL; Tocco, F | 1 |
| Janssen, PA; Niemegeers, CJ; Schellekens, KH | 1 |
| Betti, R; Casanueva, F; Cocchi, D; Motta, T; Müller, EE; Zanardi, P | 1 |
| Gueudet, C; Le Fur, G; Rinaldi-Carmona, M; Santucci, V; Soubrié, P | 1 |
| Bergstrom, DA; Gonzalez, AM; Huang, KX; Kreiss, DS; Sibley, DR; Walters, JR | 1 |
| Janssen, PF; Leysen, JE; Megens, AA; Schotte, A | 1 |
| Awouters, FH; Janssen, PA | 1 |
| Geerts, RJ; Heykants, JJ; Leysen, JE; Megens, AA; Meuldermans, WE; van Beijsterveldt, LE; Van den Eynde, HM | 1 |
| Conway, PC; Corbett, R; Dunn, RW; Hartman, H; Helsley, GC; Kerman, LL; Strupczewski, JT; Woods, AT | 1 |
| Bordeau, KJ; Chiang, Y; Conway, PG; Corbett, R; Glamkowski, EJ; Hartman, HB; Helsley, GC; Strupczewski, JT; Szewczak, MR; Wilmot, CA | 1 |
| Lin, MY; Walters, DE | 1 |
| Carlsson, A; Huff, RM; Kling-Petersen, T; Svensson, K; Waters, N | 1 |
| Connelly, ST; Lehmann, H; Shepard, PD | 1 |
| Eguíbar, JR; Holmgren, B; Santos, A; Urbá-Holmgren, R | 1 |
| Clapham, J; Kilpatrick, GJ | 1 |
| Hargreaves, RJ; Hill, RG; Rycroft, W; Tattersall, FD | 1 |
| Kurumiya, S; Miura, Y; Noda, Y; Oka, M | 1 |
| Abreu, ME; Borosky, S; Clissold, DB; Erickson, RH; Hartman, T; Jones, BE; Karbon, EW; Mansbach, RS; Natalie, KJ; Pontecorvo, MJ | 1 |
| Brougham, LR; Conway, PG; Ellis, DB; Roehr, JE; Szczepanik, AM; Wilmot, CA | 1 |
| Brown, D; Byrd, G; Feldman, DJ; Flannery, R; Frank, RA; Kehne, JH; Shah, S; Soni, S | 1 |
| Carlsson, A; Merello, M; Pirtosek, Z; Stern, G | 1 |
| Curzon, P; Decker, MW | 1 |
| McAllister, KH; Pratt, JA | 1 |
| Fukuda, H; Furukawa, N; Koga, T; Nakamura, E; Shiroshita, Y | 1 |
| Barwick, VS; Hicks, PB; Jones, DH; Richter, JT; Young, KA | 1 |
| Gordon, M; Heinz-Esser, K; Kanwal, JS; Peng, JP | 1 |
| Andrén, PE; Ekesbo, A; Gunne, LM; Sonesson, C; Tedroff, J | 1 |
| Karoum, F; Masserano, JM; Wyatt, RJ | 1 |
| Attarzadeh, M; Farzin, D | 1 |
| Fu, D; Javitch, JA; Lin, H; Strange, PG; Wilson, J | 1 |
| Andrews, PL; Kovacs, M; Watson, JW | 1 |
| Tamminga, CA | 1 |
| Gobert, A; Lejeune, F; Millan, MJ | 1 |
| Bordeleau, M; Brooks, KM; Corbett, TJ; de Lannoy, I; Hendrix, JA; Kafka, S; Kamboj, RK; Kapples, KJ; Laws-Ricker, L; Lee, DK; Owolabi, J; Palermo, MG; Rizkalla, G; Shimshock, SJ; Shutske, GM; Tomer, JD; Vargas, HM | 1 |
| Bonhaus, DW; Hedley, LR; Lemaire, M; Lowe, DA; Martin, RS; Secchi, RL; Sung, E | 1 |
| da Silva, GE; Fernandes, MS; Takahashi, RN | 1 |
| Ceballos-Baumann, A | 1 |
| De Groote, C; Fischer, G; Jenner, P; Kemp, JA; Klockgether, T; Löschmann, PA; Smith, L; Wüllner, U | 1 |
| Long, LE; Malone, DT; Taylor, DA | 1 |
| Aceves, J; Arias-Montaño, JA; García-Ramírez, M | 1 |
| Marona-Lewicka, D; Nichols, DE; Thisted, RA | 1 |
| Andersen, MB; Brandt-Christensen, M; Fink-Jensen, A; Gerlach, J; Werge, T | 1 |
| Artaiz, I; Castro, E; Del Olmo, E; Díaz, A; Innerárity, A; Labeaga, L; Orjales, A; Pazos, A; Pena, R; Ruiz-Ortega, JA; Zazpe, A | 1 |
| Auclair, AL; Besnard, J; Depoortère, R; Kleven, MS; Newman-Tancredi, A | 1 |
| Barr, AM; Geyer, MA; Markou, A; Powell, SB | 1 |
| Akhtar, M; Ali, A; Pillai, KK; Uma Devi, P; Vohora, D | 1 |
| Bouchard, K; Hohnadel, E; Terry, AV | 1 |
| Ago, Y; Baba, A; Hashimoto, H; Kawasaki, T; Koda, K; Matsuda, T | 1 |
| Gómez-Urquijo, S; Morera-Herreras, T; Ruiz-Ortega, JA; Ugedo, L | 1 |
| Chen, Z; Hu, DN; Liu, CQ; Liu, FX; Luo, JH | 1 |
| Ago, Y; Kawasaki, T; Kobayashi, H; Koda, K; Matsuda, T; Takuma, K; Yano, K | 1 |
| Chang, WL; Durbin, JP; Luedtke, RR; Mach, RH; Park, PE; Swerdlow, NR; Weber, M | 1 |
| Haeri-Rohani, A; Nasehi, M; Sahebgharani, M; Zarrindast, MR | 1 |
| Amanlou, M; Foroumadi, A; Rayatnia, F; Sakhteman, A; Shafiee, A; Sharifzadeh, M | 1 |
| Arrang, JM; Burban, A; Dumoulin, D; Frances, H; Le Pen, G; Rose, C; Sadakhom, C | 1 |
| Calas, AG; Goursaud, S; Hermans, E; Jeanjean, AP; Koener, B; Maloteaux, JM; Van De Stadt, M | 1 |
| Atack, J; Cik, M; De Bruyn, M; Hendrickx, H; Langlois, X; Lavreysen, H; Macdonald, G; Megens, A; Peeters, L; te Riele, P; Vermeire, J; Wouters, R | 1 |
| Ahmad, A; Ishrat, T; Islam, F; Khan, A; Khan, MM; Safhi, MM; Shrivastava, P; Tabassum, R; Vaibhav, K | 1 |
| Chen, Y; Liu, BF; Liu, X; Xu, X; Zhang, G | 1 |
| Singer, P; Yee, BK; Zhang, W | 1 |
| Aguiar, JC; Guimarães, FS; Lisboa, SF; Magesto, AC; Resstel, LB | 1 |
| Hacksell, U; Hubbard, D; McFarland, K | 1 |
| Baladi, MG; France, CP; Newman, AH | 1 |
| Riedel, G; Robinson, L | 1 |
| Cui, G; Hua, F; Shen, X; Shi, H; Wang, X; Yang, X; Zhang, S; Zhang, W; Zhang, Z; Zhao, H; Zu, J | 1 |
| Masui, A; Minamimoto, S; Mizobe, Y; Mizuguchi, Y; Ochiai, M; Ohno, Y; Shimizu, S; Tamura, M; Tatara, A | 1 |
4 review(s) available for apomorphine and piperidines
| Article | Year |
|---|---|
Dopamine receptor agonists: mechanisms underlying autoreceptor selectivity. II. Theoretical considerations.
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Corpus Striatum; Cyclic AMP; Dextroamphetamine; Dopamine; Humans; Isomerism; Lisuride; Models, Neurological; Molecular Conformation; Motor Activity; Nucleus Accumbens; Piperidines; Pituitary Gland, Anterior; Prolactin; Rats; Receptors, Dopamine; Substantia Nigra; Synaptosomes | 1985 |
Neurophysiological evidence that D-1 dopamine receptor blockade attenuates postsynaptic but not autoreceptor-mediated effects of dopamine agonists.
Topics: Animals; Apomorphine; Basal Ganglia; Benzazepines; Dextroamphetamine; Dopamine Antagonists; Electrophysiology; Ergolines; Globus Pallidus; Haloperidol; Ketanserin; Neurons; Pergolide; Piperidines; Quinpirole; Rats; Receptors, Dopamine; Substantia Nigra | 1986 |
Partial dopamine agonists in the treatment of psychosis.
Topics: Animals; Apomorphine; Autoreceptors; Brain; Dopamine Agonists; Humans; Piperidines; Psychotic Disorders; Receptors, Dopamine | 2002 |
[Diagnosis and treatment of Parkinson's syndrome. What is important for the general practitioner?].
Topics: Aged; Amantadine; Antiparkinson Agents; Apomorphine; Botulinum Toxins; Catechols; Cholinesterase Inhibitors; Clinical Trials as Topic; Diagnosis, Differential; Dopamine Agents; Dopamine Agonists; Enzyme Inhibitors; Ergot Alkaloids; Family Practice; Female; Humans; Levodopa; Male; Nitriles; Parkinson Disease; Parkinson Disease, Secondary; Parkinsonian Disorders; Piperidines | 2003 |
3 trial(s) available for apomorphine and piperidines
| Article | Year |
|---|---|
Therapeutic efficacy of apomorphine combined with an extracerebral inhibitor of dopamine receptors in Parkinson's disease.
Topics: Apomorphine; Benzimidazoles; Blood-Brain Barrier; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Parkinson Disease; Piperidines; Placebos; Receptors, Dopamine | 1979 |
Effect of domperidone on gastric emptying and secretion.
Topics: Antiemetics; Apomorphine; Benzimidazoles; Duodenal Ulcer; Gastric Emptying; Gastric Juice; Humans; Male; Piperidines; Secretory Rate; Stimulation, Chemical | 1979 |
Preclamol and parkinsonian fluctuations.
Topics: Antiparkinson Agents; Apomorphine; Blood Pressure; Dopamine Agonists; Female; Humans; Injections, Subcutaneous; Male; Middle Aged; Movement; Parkinson Disease; Piperidines; Receptors, Dopamine D1; Receptors, Dopamine D2 | 1993 |
189 other study(ies) available for apomorphine and piperidines
| Article | Year |
|---|---|
Sufentanil, a very potent and extremely safe intravenous morphine-like compound in mice, rats and dogs.
Topics: Analgesia; Analgesics, Opioid; Anilides; Animals; Antiemetics; Apomorphine; Dogs; Female; Fentanyl; Injections, Intravenous; Lethal Dose 50; Male; Meperidine; Mice; Mice, Inbred Strains; Morphine; Nalorphine; Piperidines; Pupil; Rats; Rats, Inbred Strains | 1976 |
Synthesis and pharmacological properties of a series of antidopaminergic piperidyl benzamides.
Topics: Animals; Apomorphine; Benzamides; Catalepsy; Depression, Chemical; Dextroamphetamine; Dopamine; Female; Humans; Male; Metoclopramide; Mice; Piperidines; Rats; Stereotyped Behavior; Structure-Activity Relationship | 1977 |
Differential antagonism of antiavoidance, cataleptic and ptotic effects of neuroleptics by biperiden.
Topics: Animals; Antipsychotic Agents; Apomorphine; Avoidance Learning; Biperiden; Blepharoptosis; Catalepsy; Dopamine Antagonists; Drug Interactions; Humans; Male; Mice; Norepinephrine; Oxotremorine; Piperidines | 1979 |
[Demonstration of dopaminergic receptors in human pituitary adenomas secreting prolactin].
Topics: Adenoma; Apomorphine; Benzimidazoles; Binding, Competitive; Humans; Kinetics; Piperidines; Pituitary Gland, Anterior; Pituitary Neoplasms; Prolactin; Receptors, Dopamine | 1979 |
The effects of psychomotor stimulants on stereotypy and locomotor activity in socially-deprived and control rats.
Topics: Amphetamine; Animals; Apomorphine; Brain Chemistry; Cocaine; Dopamine; Dose-Response Relationship, Drug; Female; Humans; Locomotion; Motor Activity; Norepinephrine; Piperidines; Rats; Social Isolation; Stereotyped Behavior | 1975 |
3H-Domperidone: a selective ligand for dopamine receptors.
Topics: Animals; Apomorphine; Benzimidazoles; Corpus Striatum; Dopamine Antagonists; In Vitro Techniques; Kinetics; Ligands; Male; Membranes; Mice; Piperidines; Receptors, Dopamine; Spiperone; Time Factors | 1979 |
Gastric relaxation by morphine, apomorphine and fentanyl in the conscious dog.
Topics: Animals; Apomorphine; Benzimidazoles; Dogs; Domperidone; Fentanyl; Haloperidol; Morphine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Naloxone; Piperidines; Stomach; Vomiting | 1979 |
[Antagonism of pre- and postsynaptic dopamine receptors by clebopride and related orthopramides].
Topics: Animals; Apomorphine; Benzamides; Dopamine Antagonists; Drug Interactions; Metoclopramide; Mice; Piperidines; Sulpiride; Synapses | 1979 |
Interspecies differences in sensitivity to the neuroleptic drug penfluridol.
Topics: Animals; Apomorphine; Behavior, Animal; Dogs; Macaca fascicularis; Macaca mulatta; Mice; Penfluridol; Piperidines; Rabbits; Rats; Receptors, Dopamine; Species Specificity | 1977 |
Comparative effects of penfluridol on circling behavior and striatal DOPAC and serum prolactin concentrations in the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Behavior; Corpus Striatum; Drug Interactions; Humans; Male; Penfluridol; Phenylacetates; Piperidines; Prolactin; Rats; Stereotyped Behavior; Time Factors | 1978 |
Changes in dopamine receptors in mouse striatum following morphine treatments.
Topics: Animals; Apomorphine; Benzimidazoles; Corpus Striatum; Homovanillic Acid; Humans; Male; Mice; Morphine; Piperidines; Receptors, Dopamine; Stereotyped Behavior; Time Factors | 1979 |
The pharmacology of a new potent, long acting neuroleptic, piflutixol.
Topics: Adenylyl Cyclases; Amphetamine; Anesthesia; Animals; Apomorphine; Arousal; Barbiturates; Behavior, Animal; Catalepsy; Dogs; Dopamine Antagonists; Escape Reaction; Ethanol; Female; Humans; Male; Methylphenidate; Mice; Motor Activity; Piperidines; Rabbits; Rats; Thioxanthenes; Tranquilizing Agents | 1977 |
[Comparison of antiapomorphinic activity of metoclopramide, sulpiride and clebopride in the rat and dog].
Topics: Administration, Oral; Animals; Apomorphine; Benzamides; Dogs; Injections, Intravenous; Metoclopramide; Piperidines; Rats; Sulpiride | 1978 |
Measurement of gastric relaxation in the experimental animal: influence of domperidone.
Topics: Animals; Apomorphine; Benzimidazoles; Cats; Dopamine Antagonists; Drug Interactions; Electric Stimulation; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Piperidines; Stomach | 1978 |
Mechanism of antiemetic action of penfluridol in the dog.
Topics: Administration, Oral; Animals; Antiemetics; Apomorphine; Dogs; Drug Antagonism; Female; Injections, Intravenous; Injections, Intraventricular; Levodopa; Male; Medulla Oblongata; Penfluridol; Piperidines | 1978 |
Proceedings: Pharmacological properties of a new oral long-acting neuroleptic drug penfluridol.
Topics: Animals; Apomorphine; Behavior, Animal; Haplorhini; Macaca mulatta; Mice; Penfluridol; Piperidines; Rats; Species Specificity | 1975 |
[Pharmacological studies of an antipschotic agent, penfluridol. (1). The central pharmacological actions].
Topics: Agonistic Behavior; Animals; Apomorphine; Avoidance Learning; Blepharoptosis; Body Temperature; Catalepsy; Cats; Central Nervous System; Chlorpromazine; Conditioning, Classical; Cooperative Behavior; Dogs; Dose-Response Relationship, Drug; Drug Synergism; Female; Haloperidol; Haplorhini; Hexobarbital; Humans; Locomotion; Male; Methamphetamine; Mice; Parasympatholytics; Penfluridol; Piperidines; Rats | 1976 |
Effects of penfluridol and other drugs on apomorphine-induced stereotyped behavior in monkeys.
Topics: Animals; Apomorphine; Behavior; Chlorpromazine; Dose-Response Relationship, Drug; Haloperidol; Humans; Injections, Subcutaneous; Macaca fascicularis; Male; Methyltyrosines; Nialamide; Penfluridol; Piperidines; Reserpine; Stereotyped Behavior; Time Factors | 1975 |
Clopimozide (R 29 764), a new highly potent and orally long-acting neuroleptic of the diphenylbutylpiperidine series.
Topics: Animals; Apomorphine; Avoidance Learning; Behavior, Animal; Benzimidazoles; Blepharoptosis; Body Temperature Regulation; Body Weight; Catalepsy; Dextroamphetamine; Dogs; Escape Reaction; Female; Guinea Pigs; Haloperidol; Humans; Lethal Dose 50; Male; Mice; Norepinephrine; Penfluridol; Pimozide; Piperidines; Rats; Self Stimulation; Stereotyped Behavior; Tranquilizing Agents | 1975 |
Sigma ligand-induced emesis in the pigeon.
Topics: Animals; Apomorphine; Columbidae; Dextromethorphan; Dizocilpine Maleate; Dopamine Agents; Guanidines; Haloperidol; Male; Pentobarbital; Phenazocine; Piperidines; Propranolol; Psychotropic Drugs; Pyrimidines; Receptors, Opioid; Receptors, sigma; Vomiting | 1992 |
The effects of pertussis toxin on dopamine D2 and serotonin 5-HT1A autoreceptor-mediated inhibition of neurotransmitter synthesis: relationship to receptor reserve.
Topics: 5-Hydroxytryptophan; Animals; Apomorphine; Brain; Dopamine Agents; GTP-Binding Proteins; Levodopa; Male; Neurotransmitter Agents; Pertussis Toxin; Piperidines; Quinolines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Serotonin; Ribose; Virulence Factors, Bordetella | 1992 |
Effects of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline on the prolactin suppression induced by a series of full and partial dopamine D2 receptor agonists in male rats.
Topics: 4-Butyrolactone; Adrenergic alpha-Antagonists; Animals; Apomorphine; Dopamine Agents; Ergolines; Levodopa; Male; Piperidines; Prolactin; Quinolines; Rats; Rats, Sprague-Dawley | 1992 |
Pre-synaptic dopaminergic control mechanisms for CCK-8 like immunoreactivity in the rat medial frontal cortex.
Topics: Animals; Apomorphine; Behavior, Animal; Cholecystokinin; Dopamine; Dopamine Agents; In Vitro Techniques; Male; Microinjections; N-Methylaspartate; Nerve Degeneration; Neurons; Piperidines; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, Dopamine | 1992 |
DuP 734 [1-(cyclopropylmethyl)-4-(2'(4''-fluorophenyl)-2'- oxoethyl)piperidine HBr], a potential antipsychotic agent: preclinical behavioral effects.
Topics: Aggression; Animals; Antipsychotic Agents; Apomorphine; Avoidance Learning; Behavior, Animal; Chlorpromazine; Haloperidol; Male; Mescaline; Mice; Mice, Inbred BALB C; Piperidines; Rats; Receptors, Serotonin; Receptors, sigma | 1992 |
Pharmacological profile of the new potent neuroleptic ocaperidone (R 79,598).
Topics: Animals; Antiemetics; Antipsychotic Agents; Apomorphine; Behavior, Animal; Body Temperature; Dogs; Dopamine Agents; Dopamine Antagonists; Eating; Female; Haloperidol; Isoxazoles; Lethal Dose 50; Locomotion; Male; Mice; Motor Activity; Muscles; Neurotransmitter Agents; Piperidines; Posture; Pyrimidinones; Rats; Rats, Inbred Strains; Risperidone; Ritanserin; Serotonin; Serotonin Antagonists; Synaptic Transmission | 1992 |
Long-term effects of imipramine on striatal dopamine autoreceptor function: involvement of both noradrenergic and serotonergic systems.
Topics: Animals; Apomorphine; Benzylamines; Corpus Striatum; Fenclonine; Homovanillic Acid; Imipramine; In Vitro Techniques; Male; Norepinephrine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Serotonin; Serotonin Antagonists | 1992 |
5-HT2 receptor antagonists reverse amphetamine-induced slowing of dopaminergic neurons by interfering with stimulated dopamine synthesis.
Topics: Action Potentials; Amphetamines; Animals; Apomorphine; Carbidopa; Dopamine; Dopamine Antagonists; Fenclonine; Levodopa; Male; Neurons; Piperidines; Rats; Rats, Inbred Strains; Ritanserin | 1992 |
Differential effects of dopamine agonists upon stimulated limbic and striatal dopamine release: in vivo voltammetric data.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Bromocriptine; Corpus Striatum; Dopamine; Dopamine Agents; Electrochemistry; Electrophysiology; Ergolines; In Vitro Techniques; Limbic System; Male; Microelectrodes; Nucleus Accumbens; Pergolide; Piperidines; Quinpirole; Rats; Rats, Inbred Strains; Stereotaxic Techniques | 1991 |
Dopamine receptors, controlling dopamine levels in rat adrenal glands-comparison with central dopaminergic autoreceptors.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenal Medulla; Animals; Apomorphine; Azepines; Diencephalon; Domperidone; Dopamine; Dopamine Agents; Epinephrine; Ergolines; Lisuride; Male; Norepinephrine; Phenanthrenes; Piperidines; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Telencephalon | 1991 |
Sigma-receptors: implication for the control of neuronal activity of nigral dopamine-containing neurons.
Topics: Animals; Apomorphine; Binding, Competitive; Dizocilpine Maleate; Dopamine; Dopamine Agents; Male; Neurons; Piperidines; Quinolines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Stereotaxic Techniques; Substantia Nigra | 1991 |
Yawning produced by dopamine agonists in rhesus monkeys.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antipsychotic Agents; Apomorphine; Benzazepines; Dopamine; Dopamine Agents; Dopamine Antagonists; Ergolines; Macaca mulatta; Male; Physostigmine; Piperidines; Quinpirole; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Yawning | 1991 |
Functional interaction between serotonin-S2 and dopamine-D2 neurotransmission as revealed by selective antagonism of hyper-reactivity to tryptamine and apomorphine.
Topics: Animals; Antipsychotic Agents; Apomorphine; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Injections, Intravenous; Isoxazoles; Male; Piperidines; Rats; Rats, Inbred Strains; Risperidone; Ritanserin; Seizures; Serotonin; Serotonin Antagonists; Synaptic Transmission; Tryptamines | 1990 |
General pharmacology of the four gastrointestinal motility stimulants bethanechol, metoclopramide, trimebutine, and cisapride.
Topics: Animals; Apomorphine; Bethanechol Compounds; Cisapride; Conditioning, Operant; Diarrhea; Dogs; Gastric Emptying; Gastrointestinal Agents; Gastrointestinal Motility; Metoclopramide; Motor Activity; Piperidines; Rats; Rats, Inbred Strains; Serotonin Antagonists; Species Specificity; Trimebutine; Vomiting | 1991 |
Atypical neuroleptics suppress dopaminergic behavioral supersensitivity.
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Clozapine; Cyproheptadine; Haloperidol; Male; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Ritanserin; Serotonin Antagonists; Sulpiride; Thioridazine | 1990 |
The role of the dopaminergic system in the modulation of the acoustic startle response in the rat.
Topics: Animals; Apomorphine; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Haloperidol; Male; Piperidines; Rats; Rats, Inbred Strains; Reflex, Startle; Stereoisomerism | 1990 |
Behavioural evidence for a functional interaction between central 5-HT2 and 5-HT1A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Apomorphine; Behavior, Animal; Central Nervous System; Dose-Response Relationship, Drug; Haloperidol; Ketanserin; Male; Methoxydimethyltryptamines; Piperidines; Prazosin; Pyrimidines; Quinolines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Ritanserin; Serotonin; Stereotyped Behavior; Tetrahydronaphthalenes | 1990 |
Pharmacology of risperidone (R 64 766), a new antipsychotic with serotonin-S2 and dopamine-D2 antagonistic properties.
Topics: Amphetamine; Animals; Antipsychotic Agents; Apomorphine; Conditioning, Psychological; Dogs; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; Haloperidol; Isoxazoles; Male; Motor Activity; Oxazoles; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Risperidone; Serotonin Antagonists | 1988 |
Ritanserin, a 5-HT2 receptor antagonist, activates midbrain dopamine neurons by blocking serotonergic inhibition.
Topics: Action Potentials; Animals; Apomorphine; Fenclonine; Male; Mesencephalon; Neurons; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Ritanserin; Serotonin Antagonists; Substantia Nigra | 1989 |
Synthesis and evaluation of optically pure [3H]-(+)-pentazocine, a highly potent and selective radioligand for sigma receptors.
Topics: Animals; Apomorphine; Binding, Competitive; Brain; Cell Membrane; Chemical Phenomena; Chemistry; Dopamine Agents; Guanidines; Guinea Pigs; Hydroxides; Molecular Structure; Pentazocine; Phencyclidine; Piperidines; Potassium; Potassium Compounds; Receptors, Dopamine; Receptors, Opioid; Receptors, sigma; Tritium | 1989 |
Dopamine autoreceptor agonists attenuate spontaneous motor activity but not spontaneous fighting in individually-housed mice.
Topics: Aggression; Agonistic Behavior; Animals; Apomorphine; Catalepsy; Dopamine Agents; Dose-Response Relationship, Drug; Housing, Animal; Male; Mice; Motor Activity; Piperidines; Social Isolation; Stereoisomerism | 1989 |
Inhibition by pertussis toxin of the soporific effects induced by stimulation of dopamine D2 autoreceptors in the ventral tegmental area in rats.
Topics: Adenylate Cyclase Toxin; Animals; Apomorphine; Electrocardiography; Male; Pertussis Toxin; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Tegmentum Mesencephali; Time Factors; Virulence Factors, Bordetella | 1989 |
Relative selectivity of 6,7-dihydroxy-2-dimethylaminotetralin, N-n-propyl-3-(3-hydroxyphenyl)piperidine, N-n-propylnorapomorphine and pergolide as agonists at striatal dopamine autoreceptors and postsynaptic dopamine receptors.
Topics: Acetylcholine; Animals; Apomorphine; Corpus Striatum; Dihydroxyphenylalanine; Ergolines; Haloperidol; Homovanillic Acid; Male; Naphthalenes; Pergolide; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reserpine; Sodium Oxybate; Tetrahydronaphthalenes; Tyrosine 3-Monooxygenase | 1985 |
Effect of dopaminergic drugs on striatal acetylcholine concentration.
Topics: Acetylcholine; Animals; Apomorphine; Corpus Striatum; Male; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1985 |
Is inhibition of striatal synaptosomal tyrosine hydroxylation by dopamine agonists a measure of dopamine autoreceptor function?
Topics: Adrenergic alpha-Agonists; Animals; Apomorphine; Azepines; Corpus Striatum; Depression, Chemical; Dopamine; Ergolines; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Pergolide; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Neurotransmitter; Synaptosomes; Tyrosine 3-Monooxygenase | 1985 |
Performance deficit induced by low doses of dopamine agonists in rats. Toward a model for approaching the neurobiology of negative schizophrenic symptomatology?
Topics: Amisulpride; Animals; Antipsychotic Agents; Apomorphine; Disease Models, Animal; Male; Phenothiazines; Pimozide; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reinforcement Schedule; Reinforcement, Psychology; Schizophrenia; Schizophrenic Psychology; Sulpiride | 1986 |
Effects of dopaminomimetics on the secretion of VIP-like immunoreactivity in conscious dogs.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amphetamine; Animals; Apomorphine; Benzazepines; Dogs; Ergolines; Nitroglycerin; Pergolide; Piperidines; Prazosin; Receptors, Dopamine; Somatostatin; Vasoactive Intestinal Peptide | 1986 |
Two automated locomotor activity tests for dopamine autoreceptor agonists.
Topics: Amphetamine; Animals; Antipsychotic Agents; Apomorphine; Drug Evaluation, Preclinical; Exploratory Behavior; Indoles; Male; Motor Activity; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1986 |
Comparison of changes in locomotor activity with striatal homovanillic acid and 3,4-dihydroxyphenylacetic acid concentrations following the bilateral intranigral injection of dopamine agonist drugs in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Corpus Striatum; Dopamine; Female; Homovanillic Acid; Motor Activity; Phenylacetates; Piperidines; Rats; Rats, Inbred Strains; Substantia Nigra; Sucrose | 1987 |
Synthesis and neuroleptic activity of a series of 1-[1-(benzo-1,4-dioxan-2-ylmethyl)-4-piperidinyl]benzim idazolone derivatives.
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Benzimidazoles; Brain; Catalepsy; Cattle; Chemical Phenomena; Chemistry; Male; Mice; Piperidines; Rats; Receptors, Dopamine; Spiperone; Structure-Activity Relationship | 1987 |
Relationship between receptor occupancy and response at striatal dopamine autoreceptors.
Topics: 4-Butyrolactone; Adrenergic alpha-Antagonists; Animals; Apomorphine; Corpus Striatum; Dihydroxyphenylalanine; Homeostasis; Hydrazines; Levodopa; Male; Piperidines; Quinolines; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1987 |
Effects of apomorphine and (+/-)-3-(3-hydroxyphenyl)-N-n-propylpiperidine, injected into the striatum, on the caudate spindle in the rat.
Topics: Animals; Antipsychotic Agents; Apomorphine; Corpus Striatum; Dopamine; Electric Stimulation; Electrophysiology; Injections; Male; Piperidines; Rats; Rats, Inbred Strains | 1987 |
Biochemical and pharmacological tests for the prediction of ability of monoamine uptake blockers to inhibit the uptake of noradrenaline in-vivo: the effects of desipramine, maprotiline, femoxetine and citalopram.
Topics: Animals; Apomorphine; Body Temperature; Brain; Citalopram; Desipramine; Male; Maprotiline; Mice; Monoamine Oxidase Inhibitors; Norepinephrine; Piperidines; Propylamines; Reserpine; Serotonin Antagonists; Thyrotropin-Releasing Hormone; Tyramine | 1987 |
Dopamine D-2 receptors in the ventral tegmental area mediate behavioural and electrocortical sleep of dopaminergic drugs in rats.
Topics: Animals; Apomorphine; Behavior, Animal; Cerebral Cortex; Dopamine Agents; Electric Stimulation; Electroencephalography; Piperidines; Rats; Receptors, Dopamine; Sleep; Tegmentum Mesencephali | 1988 |
Antipsychotic properties of new N-(4-substituted-1-piperazinylethyl)- and N-(4-substituted-1-piperidinylethyl)-phthalimides.
Topics: Animals; Antipsychotic Agents; Apomorphine; Catalepsy; Chemical Phenomena; Chemistry; Female; Guinea Pigs; Lethal Dose 50; Male; Mice; Motor Activity; Parasympatholytics; Pergolide; Phthalimides; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Stereotyped Behavior | 1988 |
Behavioural stimulation is induced by separate dopamine D-1 and D-2 receptor sites in reserpine-pretreated but not in normal rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Behavior, Animal; Benzazepines; Catalepsy; Ergolines; Hydroxydopamines; Ketanserin; Male; Motor Activity; Oxidopamine; Pergolide; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Reserpine; Stereotyped Behavior | 1985 |
Monoaminergic involvement in the pharmacological actions of buspirone.
Topics: Animals; Apomorphine; Behavior, Animal; Brain; Buspirone; Dopamine; Ketanserin; Male; Methoxydimethyltryptamines; Monoamine Oxidase; p-Chloroamphetamine; Piperazines; Piperidines; Psychotropic Drugs; Pyrimidines; Rats; Serotonin | 1985 |
Subtypes of the 5-HT receptor mediating the behavioural responses to 5-methoxy-N,N-dimethyltryptamine in the rat.
Topics: Animals; Apomorphine; Behavior, Animal; Betaxolol; Haloperidol; Ketanserin; Male; Pindolol; Piperidines; Prazosin; Propanolamines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Reserpine; Spiperone | 1985 |
Ventral tegmental area: site through which dopamine D2-receptor agonists evoke behavioural and electrocortical sleep in rats.
Topics: Animals; Apomorphine; Cerebral Cortex; Electroencephalography; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Sleep; Sulpiride; Tegmentum Mesencephali | 1988 |
7-[3-(4-[2,3-Dimethylphenyl]piperazinyl)propoxy]-2(1H)-quinolinone (OPC-4392), a presynaptic dopamine autoreceptor agonist and postsynaptic D2 receptor antagonist.
Topics: Animals; Apomorphine; Brain; Corpus Striatum; Diencephalon; Dihydroxyphenylalanine; Frontal Lobe; Hydroxydopamines; Kainic Acid; Kinetics; Male; Mice; Mice, Inbred ICR; Motor Activity; Oxidopamine; Piperazines; Piperidines; Quinolines; Quinolones; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereotyped Behavior; Telencephalon | 1988 |
Heterogeneous rotational responsiveness in 6-hydroxydopamine-denervated rats: pharmacological and neurochemical characterization.
Topics: Animals; Apomorphine; Benzopyrans; Brain Chemistry; Corpus Striatum; Dopamine; Ergolines; Hydroxydopamines; Male; Oxidopamine; Piperidines; Quinpirole; Rats; Rats, Inbred Strains; Rotation; Stereotyped Behavior; Sympathectomy, Chemical | 1988 |
Complete conversion of brain D2 dopamine receptors from the high- to the low-affinity state for dopamine agonists, using sodium ions and guanine nucleotide.
Topics: Animals; Apomorphine; Brain; Guanine Nucleotides; In Vitro Techniques; Ketanserin; Male; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sodium; Spiperone; Tetrahydronaphthalenes; Tritium | 1985 |
Effects of intraperitoneal administration of apomorphine and the isomers of 3-(1-propyl-3-piperidinyl)phenol on the firing activity of substantia nigra dopamine neurons: comparison of agonist efficacies and development of acute tolerance.
Topics: Action Potentials; Animals; Apomorphine; Drug Tolerance; Injections, Intraperitoneal; Injections, Intravenous; Male; Neurons; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereoisomerism; Substantia Nigra | 1988 |
Pharmacological profile of dopamine receptor agonists as studied by brain dialysis in behaving rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Azepines; Behavior, Animal; Benzazepines; Brain; Dialysis; Dopamine; Ergolines; Homovanillic Acid; Isomerism; Male; Motor Activity; Neurons; Pergolide; Piperidines; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Time Factors | 1988 |
Drug-induced penile erections in rats: indications of serotonin1B receptor mediation.
Topics: 5-Hydroxytryptophan; Animals; Apomorphine; Benserazide; Haloperidol; Male; Nialamide; Penile Erection; Piperidines; Propranolol; Quipazine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Tranquilizing Agents | 1987 |
Apomorphine-induced penile erection and yawning: site of action in brain.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Benzazepines; Brain; Dopamine; Dopamine Antagonists; Ergolines; Male; Microinjections; Paraventricular Hypothalamic Nucleus; Penile Erection; Piperidines; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereoisomerism; Yawning | 1987 |
Partial protection against hyperbaric oxygen induced convulsions by dopaminergic agents in mice: possible involvement of autoreceptors?
Topics: Animals; Antiparkinson Agents; Apomorphine; Body Temperature; Dose-Response Relationship, Drug; Haloperidol; Hyperbaric Oxygenation; Levodopa; Male; Mice; Mice, Inbred CBA; Piperidines; Reaction Time; Receptors, Dopamine; Respiration; Seizures | 1987 |
Opposite regulation of serotonin-S2 and dopamine-D2 receptors in rat brain following chronic receptor blockade.
Topics: Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Diazepam; Dopamine Antagonists; Frontal Lobe; Gene Expression Regulation; Ketanserin; Male; Models, Biological; Piperidines; Pyrimidinones; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Serotonin; Serotonin Antagonists; Tryptamines | 1987 |
Differential electrophysiological effects of 3-PPP and its enantiomers on dopamine autoreceptors and postsynaptic receptors.
Topics: Action Potentials; Animals; Apomorphine; Electrodes, Implanted; Globus Pallidus; Male; Neurons; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereoisomerism; Substantia Nigra; Synapses | 1986 |
A stereochemical explanation of the dopamine agonist and antagonist activity of stereoisomeric pairs.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Apomorphine; Chemical Phenomena; Chemistry; Dopamine; Dopamine Antagonists; Molecular Conformation; Naphthalenes; Piperidines; Receptors, Dopamine; Stereoisomerism; Structure-Activity Relationship; Tetrahydronaphthalenes; Thermodynamics | 1986 |
Stereoselective inhibition of prolactin secretion by (-)-HW-165, a novel 3-PPP congener; further support for similarities between central DA autoreceptors and pituitary lactotroph DA receptors.
Topics: 4-Butyrolactone; Animals; Apomorphine; Depression, Chemical; Male; Phenanthrenes; Piperidines; Pituitary Gland; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reserpine; Stereoisomerism | 1986 |
(+)-3-(3-hydroxyphenyl)-N-(1-propyl)piperidine [(+)-3-PPP] but not (-)-3-PPP produces (+)-N-allylnormetazocine-like (SKF 10,047) discriminative stimuli.
Topics: Animals; Apomorphine; Discrimination Learning; Dose-Response Relationship, Drug; Isomerism; Male; Phenazocine; Phencyclidine; Piperidines; Rats; Rats, Inbred F344 | 1986 |
Dopaminergic agents including 3-PPP and its enantiomers on medial septal self-stimulation.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Appetite Depressants; Benzazepines; Dextroamphetamine; Drug Interactions; Haloperidol; Male; Nomifensine; Piperidines; Rats; Receptors, Dopamine; Self Stimulation; Stereoisomerism; Sulpiride; Tetrahydronaphthalenes | 1985 |
Dopamine receptor-mediated hypothermia induced in rats by (+)-, but not by (-)-3-PPP.
Topics: Animals; Apomorphine; Biogenic Amines; Body Temperature; Brain Chemistry; Dose-Response Relationship, Drug; Male; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereoisomerism | 1985 |
Lack of effect of intranigral administration of a dopamine analogue, (+/-)-3-(3-hydroxyphenyl)-N,n-propylpiperidine [(+/-)-3-PPP], on nigrostriatal dopamine neurones.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Corpus Striatum; Dopamine; Female; Homovanillic Acid; Motor Activity; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Substantia Nigra | 1985 |
Pharmacological study of pipotiazine (19.366 R.P.) and its undecylenic (19.551 R.P.) and palmitic (19.552 R.P.) esters.
Topics: Amphetamine; Animals; Antipsychotic Agents; Apomorphine; Catalepsy; Dogs; Esters; Fluphenazine; Guinea Pigs; Humans; Lethal Dose 50; Mice; Motor Activity; Palmitic Acids; Phenothiazines; Piperidines; Rats; Respiration; Sleep; Species Specificity; Sulfonamides; Time Factors; Undecylenic Acids | 1973 |
Studies of various amphetamines, apomorphine and clonidine on body temperature and brain 5-hydroxytryptamine metabolism in rats.
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Body Temperature; Brain; Brain Chemistry; Carboxylic Acids; Chromatography, Ion Exchange; Clonidine; Fever; Hydroxyindoleacetic Acid; Male; Methylphenidate; Naphthyridines; Phenmetrazine; Piperidines; Rats; Serotonin; Spectrometry, Fluorescence; Temperature | 1974 |
The central nervous system pharmacology of an anti-emetic dihydroindolone derivative.
Topics: Aggression; Animals; Antiemetics; Apomorphine; Behavior, Animal; Cats; Chlorpromazine; Conditioning, Operant; Copper; Dextroamphetamine; Dioxoles; Dogs; Drug Synergism; Electroencephalography; Escape Reaction; Ethanol; Haplorhini; Humans; Indoles; Male; Mice; Motor Activity; Piperidines; Postural Balance; Rats; Seizures; Species Specificity; Stereotyped Behavior; Vomiting | 1973 |
Dopamine-induced inhibition of synaptic transmission in lumbar paravertebral ganglia of the dog.
Topics: Acetamides; Action Potentials; Animals; Antihypertensive Agents; Apomorphine; Blood Pressure; Butyrophenones; Catecholamines; Chlorpromazine; Dogs; Dopamine; Dose-Response Relationship, Drug; Ergonovine; Ganglia, Spinal; Haloperidol; Isoproterenol; Methane; Norepinephrine; Phenoxybenzamine; Phentolamine; Pimozide; Piperidines; Synapses; Synaptic Transmission; Vasodilator Agents | 1973 |
Stereotyped and non-stereotyped behaviour in rats induced by various stimulant drugs.
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Brain; Caffeine; Central Nervous System; Cocaine; Lysergic Acid Diethylamide; Male; Methamphetamine; Methylphenidate; Nikethamide; Pemoline; Phenmetrazine; Piperidines; Rats | 1969 |
Influences of cholinergic mechanisms on the function and turnover of brain dopamine.
Topics: Animals; Apomorphine; Atropine; Basal Ganglia; Brain; Catalepsy; Cyclopentanes; Dopamine; Hallucinogens; Haloperidol; Humans; Mandelic Acids; Norepinephrine; Parasympatholytics; Piperidines; Rats; Scopolamine; Trihexyphenidyl | 1971 |
Synthesis and preliminary pharmacology of a novel butyrophenone derivative, ID-4708.
Topics: Animals; Apomorphine; Avoidance Learning; Behavior, Animal; Butyrophenones; Catalepsy; Cats; Chlorpromazine; Drug Evaluation, Preclinical; Drug Synergism; Electroencephalography; Epinephrine; Haloperidol; Hexobarbital; Humans; Hydrocarbons, Fluorinated; Imipramine; Lethal Dose 50; Male; Methamphetamine; Mice; Motor Activity; Pain; Piperidines; Rats; Trifluperidol | 1974 |
Release of brain dopamine as the probable mechanism for the hypothermic effect of D-amphetamine.
Topics: Animals; Apomorphine; Brain Chemistry; Clonidine; Dextroamphetamine; Dihydroxyphenylalanine; Dopamine; Drug Combinations; Glycolates; Haloperidol; Hydroxydopamines; Hypothermia; Male; Methysergide; Phenoxybenzamine; Pimozide; Piperidines; Propranolol; Pyrrolidines; Rats; Serotonin; Tyramine | 1972 |
Metabolism of diphenidol. Urinary products in humans and dogs.
Topics: Administration, Oral; Amino Acids; Animals; Antiemetics; Apomorphine; Butanols; Carbon Isotopes; Chromatography, Paper; Chromatography, Thin Layer; Dogs; Female; Glucuronates; Humans; Hydrolysis; Male; Piperidines; Valerates | 1972 |
The conformation of neuroleptic drugs.
Topics: Amines; Apomorphine; Benperidol; Butyrophenones; Chlorpromazine; Haloperidol; Hydrogen; Models, Structural; Molecular Conformation; Phenothiazines; Piperidines; Reserpine; Structure-Activity Relationship; Thiothixene; Thioxanthenes; Tranquilizing Agents; X-Ray Diffraction | 1974 |
Dopamine analogues for studies of parkinsonism.
Topics: Apomorphine; Dopamine; Humans; Parkinson Disease; Piperidines | 1970 |
Pharmacological studies on 5-(3-(4-piperidino-4-carbamoyl-piperidino)-propyl)-10,11-dihydro-5(H)-dibenz-(b,f)-azepine (carpipramine) dihydrochloride, a new psychotropic agent.
Topics: Amphetamine; Analgesics; Animals; Anti-Inflammatory Agents; Anticonvulsants; Antidepressive Agents; Apomorphine; Benzazepines; Blood Pressure; Body Temperature; Conditioning, Classical; Depression, Chemical; Dogs; Drug Synergism; Electroshock; Female; Guinea Pigs; Imipramine; In Vitro Techniques; Locomotion; Male; Mice; Muscle Contraction; Muscle, Smooth; Nictitating Membrane; Piperidines; Rabbits; Rats; Reserpine; Sleep; Stimulation, Chemical; Time Factors; Tremorine | 1968 |
Blockade of apomorphine pecking with phenothiazines.
Topics: Animals; Apomorphine; Behavior, Animal; Birds; Chemistry, Organic; Chemistry, Pharmaceutical; Chlorpromazine; Organic Chemistry Phenomena; Phenothiazines; Piperazines; Piperidines; Psychopharmacology; Pyrrolidines; Tranquilizing Agents | 1965 |
(+)- and (-)-3-PPP exhibit different intrinsic activity at striatal dopamine autoreceptors controlling dopamine synthesis.
Topics: 4-Butyrolactone; Animals; Apomorphine; Corpus Striatum; Dopamine; Isomerism; Male; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Neurotransmitter | 1984 |
Contrasting interactions of pipradrol, d-amphetamine, cocaine, cocaine analogues, apomorphine and other drugs with conditioned reinforcement.
Topics: Animals; Apomorphine; Central Nervous System Stimulants; Cocaine; Conditioning, Operant; Dextroamphetamine; Flupenthixol; Male; Morphine; Piperidines; Rats; Reinforcement, Psychology | 1983 |
Different actions of TL-99 and 3-PPP in producing contraversive turning in the 6-OHDA-lesioned rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Apomorphine; Female; Hydroxydopamines; Motor Activity; Naphthalenes; Oxidopamine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Substantia Nigra; Tetrahydronaphthalenes; Yohimbine | 1983 |
Differential effects of the enantiomers of 3-(3-hydroxyphenyl)-N-n-propylpiperidine (3-PPP) at dopamine receptor sites.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Corpus Striatum; Dopamine; Homovanillic Acid; Male; Mice; Molecular Conformation; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereoisomerism; Synaptosomes; Tyrosine 3-Monooxygenase | 1983 |
Effects of apomorphine, TL-99 and 3-PPP on yawning in rats.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Apomorphine; Behavior, Animal; Haloperidol; Male; Naphthalenes; Piperidines; Rats; Tetrahydronaphthalenes | 1984 |
Discriminative stimulus properties of lergotrile.
Topics: Animals; Apomorphine; Discrimination Learning; Dose-Response Relationship, Drug; Ergolines; Ergonovine; Haloperidol; Lisuride; Lysergic Acid Diethylamide; Male; Piperidines; Pizotyline; Quipazine; Rats; Rats, Inbred Strains; Sulpiride | 1984 |
Presynaptic dopaminergic agonists modify brain glucose metabolism in a way similar to the neuroleptics.
Topics: Animals; Antipsychotic Agents; Apomorphine; Brain; Catecholamines; Ergolines; Glucose; Naphthalenes; Piperidines; Rats; Reserpine; Tetrahydronaphthalenes | 1984 |
The ergolene derivative MPME induces in the rat a behavioural syndrome associated with activation of dopamine D-1 receptors belonging to the dotted type of forebrain dopamine nerve terminals.
Topics: Animals; Antipsychotic Agents; Apomorphine; Diencephalon; Ergolines; Humans; Male; Motor Activity; Nerve Endings; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Stereotyped Behavior; Syndrome; Telencephalon | 1984 |
Neurochemical effects of danitracen (WA-355): mechanism of action.
Topics: Amphetamine; Animals; Apomorphine; Brain Chemistry; Humans; Hydroxyindoleacetic Acid; Hyperkinesis; Norepinephrine; Piperidines; Rats; Serotonin | 1982 |
Dopamine agonists stimulate protein carboxylmethylation in striatal synaptosomes.
Topics: Animals; Apomorphine; Butaclamol; Corpus Striatum; Dopamine; Hydroxydopamines; In Vitro Techniques; Male; Nerve Tissue Proteins; Piperidines; Potassium; Protein Methyltransferases; Protein O-Methyltransferase; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Synaptosomes | 1982 |
[Effect of an imidazobenzodiazepine (RO 15-1788) on aggressive behavior in mice].
Topics: Aggression; Animals; Apomorphine; Benzodiazepinones; Brain; Catalepsy; Dose-Response Relationship, Drug; Flumazenil; Haloperidol; Humans; Hydroxyindoleacetic Acid; Male; Mice; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Serotonin; Serotonin | 1984 |
A behavioural study of the changes in the central nervous system of mice after subchronic treatment with the selective dopamine autoreceptor agonist 3-PPP (dl-3-[3-hydroxyphenyl]-N-n-propylpiperidine).
Topics: Animals; Apomorphine; Behavior, Animal; Dextroamphetamine; Dose-Response Relationship, Drug; Male; Motor Activity; Muridae; Piperidines; Receptors, Dopamine; Synaptic Transmission | 1982 |
Central dopamine receptor agonist and antagonist actions of the enantiomers of 3-PPP.
Topics: Animals; Apomorphine; Behavior, Animal; Biogenic Amines; Brain Chemistry; Dextroamphetamine; Male; Motor Activity; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reserpine; Stereoisomerism | 1983 |
Dopamine receptor agonists: intrinsic activity vs. state of receptor.
Topics: Animals; Apomorphine; Brain; Denervation; Exploratory Behavior; Hydroxydopamines; Oxidopamine; Piperidines; Prolactin; Rats; Receptors, Dopamine; Stereoisomerism; Sympathectomy, Chemical | 1983 |
Postsynaptic dopamine agonistic effects of 3-PPP enantiomers revealed by bilateral 6-hydroxy-dopamine lesions and by chronic reserpine treatment in rats.
Topics: Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Drug Interactions; Hydroxydopamines; Male; Oxidopamine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reserpine; Stereoisomerism; Stimulation, Chemical | 1984 |
Evidence for heterogeneous rotational responsiveness to apomorphine, 3-PPP and SKF 38393 in 6-hydroxydopamine-denervated rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Benzazepines; Clozapine; Ergolines; Humans; Hydroxydopamines; Male; Oxidopamine; Pergolide; Piperidines; Postural Balance; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereotyped Behavior; Sympathectomy, Chemical | 1984 |
Effects of atypical antidepressants on LSD potentiated apomorphine hypermotility in rats.
Topics: Animals; Apomorphine; Cyproheptadine; Lysergic Acid Diethylamide; Male; Mianserin; Motor Activity; Piperidines; Pizotyline; Rats; Serotonin Antagonists | 1980 |
The yawning-penile erection syndrome as a model for putative dopamine autoreceptor activity.
Topics: Animals; Apomorphine; Drug Interactions; Haloperidol; Inhalation; Isomerism; Male; Models, Psychological; Penis; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Respiration; Sexual Behavior, Animal; Syndrome | 1984 |
Apomorphine and haloperidol-induced effects on male rat sexual behavior: no evidence for actions due to stimulation of central dopamine autoreceptors.
Topics: Animals; Apomorphine; Brain; Haloperidol; Male; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sexual Behavior, Animal | 1984 |
The search for selective dopaminergic autoreceptor agonists.
Topics: Animals; Apomorphine; Dextroamphetamine; Dose-Response Relationship, Drug; Motor Activity; Optical Rotation; Piperidines; Rats; Receptors, Dopamine; Reserpine | 1983 |
Further functional in vitro comparison of pre- and postsynaptic dopamine receptors in the rabbit caudate nucleus.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acetylcholine; Animals; Apomorphine; Benzazepines; Caudate Nucleus; Choline; Clonidine; Female; Male; Piperidines; Rabbits; Receptors, Dopamine | 1983 |
Effects of pirenperone and ketanserin on rat prolactin secretion in vivo and in vitro.
Topics: Animals; Apomorphine; Dose-Response Relationship, Drug; In Vitro Techniques; Ketanserin; Lysergic Acid Diethylamide; Male; Piperidines; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Serotonin Antagonists; Tranquilizing Agents | 1983 |
Similarities of the effects of apomorphine and 3-PPP on serotonin neurons.
Topics: Animals; Apomorphine; Chromatography, High Pressure Liquid; Corpus Striatum; Haloperidol; Hippocampus; Male; Neurons; Piperidines; Raphe Nuclei; Rats; Rats, Inbred Strains; Receptors, Dopamine; Serotonin; Spectrometry, Fluorescence | 1983 |
Interaction of (+)- and (-)-3-PPP with the dopamine receptor in the anterior pituitary gland.
Topics: Animals; Apomorphine; Binding Sites; Cell Membrane; Depression, Chemical; In Vitro Techniques; Male; Methyltyrosines; Piperidines; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereoisomerism | 1984 |
Stimulation of dopamine autoreceptors elicits "premature ejaculation" in rats.
Topics: Animals; Apomorphine; Copulation; Domperidone; Dopamine Antagonists; Ejaculation; Female; Haloperidol; Lisuride; Male; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sexual Behavior, Animal | 1984 |
Assessment of dopamine autoreceptor agonist properties of apomorphine, (+)-3-PPP and (-)-3-PPP by recording of yawning behaviour in rats.
Topics: Animals; Apomorphine; Behavior, Animal; Domperidone; Male; Motor Activity; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereoisomerism; Sulpiride | 1984 |
Some behavioral effects of hallucinogens are mediated by a postsynaptic serotonergic action: evidence from single unit studies in freely moving cats.
Topics: Animals; Apomorphine; Behavior, Animal; Cats; DOM 2,5-Dimethoxy-4-Methylamphetamine; Dose-Response Relationship, Drug; Female; Hallucinogens; Ketanserin; Lisuride; Lysergic Acid Diethylamide; Metergoline; Mianserin; Piperidines; Receptors, Serotonin; Serotonin Antagonists; Synapses | 1984 |
3-Phenylpiperidines. Central dopamine-autoreceptor stimulating activity.
Topics: 5-Hydroxytryptophan; Animals; Apomorphine; Central Nervous System; Chemical Phenomena; Chemistry; Dihydroxyphenylalanine; Drug Interactions; Male; Motor Activity; Neurons; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stimulation, Chemical | 1981 |
A pharmacological comparison of 6,7-dihydroxy-2-dimethylaminotetralin (TL-99) and N-n-propyl-3-(3-hydroxyphenyl)piperidine with (3-PPP) selected dopamine agonists.
Topics: 4-Butyrolactone; Animals; Apomorphine; Cell Membrane; Corpus Striatum; Female; Humans; Hydroxydopamines; Naphthalenes; Oxidopamine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Tetrahydronaphthalenes | 1982 |
Biphasic effects of some dopamine agonists on striatal acetylcholine concentrations.
Topics: Acetylcholine; Animals; Apomorphine; Corpus Striatum; Dopamine; Male; Piperidines; Piribedil; Rats; Tetrahydronaphthalenes; Time Factors | 1983 |
Inhibition of reverse peristalsis of the intestine by domperidone.
Topics: Animals; Antiemetics; Apomorphine; Benzimidazoles; Dogs; Domperidone; Gastrointestinal Motility; Peristalsis; Piperidines | 1981 |
Interaction of the putative dopamine autoreceptor agonists 3-PPP and TL-99 with [3H]apomorphine binding sites in rat striatal membranes.
Topics: Animals; Apomorphine; Binding Sites; Binding, Competitive; Corpus Striatum; In Vitro Techniques; Kinetics; Membranes; Naphthalenes; Piperidines; Rats; Receptors, Dopamine; Spiperone; Tetrahydronaphthalenes | 1982 |
Effect of 3-PPP, a putative dopamine autoreceptor agonist, on rat serum prolactin levels.
Topics: Animals; Apomorphine; Binding, Competitive; Humans; Male; Piperidines; Prolactin; Rats; Receptors, Dopamine; Reserpine; Spiperone; Stereotyped Behavior | 1981 |
Three classes of dopamine receptor (D-2, D-3, D-4) identified by binding studies with 3H-apomorphine and 3H-domperidone.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Benzimidazoles; Brain; Corpus Striatum; Domperidone; Guanosine Triphosphate; Hot Temperature; Kinetics; Male; Piperidines; Protein Binding; Protein Denaturation; Rats; Receptors, Dopamine | 1980 |
Kainate lesion dissociates striatal dopamine receptor radioligand binding sites.
Topics: Animals; Apomorphine; Benzimidazoles; Corpus Striatum; Domperidone; Flupenthixol; In Vitro Techniques; Kainic Acid; Male; Piperidines; Pyrrolidines; Radioligand Assay; Rats; Receptors, Dopamine; Spiperone | 1981 |
Avoidance learning and mechanism of the protective effect of apomorphine against hypoxia.
Topics: Animals; Apomorphine; Atmospheric Pressure; Avoidance Learning; Benzimidazoles; Domperidone; Female; Hypoxia; Monoamine Oxidase Inhibitors; Phenoxybenzamine; Pimozide; Piperidines; Propranolol; Rats; Yohimbine | 1981 |
Preliminary observations on the interaction of domperidone with peripheral dopamine receptors.
Topics: Animals; Antiemetics; Apomorphine; Benzimidazoles; Dogs; Domperidone; Dopamine; Ganglia; In Vitro Techniques; Piperidines; Receptors, Dopamine; Vasodilation | 1981 |
Pharmacological profiles of the putative dopamine autoreceptor agonists 3-PPP and TL-99.
Topics: 4-Butyrolactone; Animals; Apomorphine; Brain; Dogs; Dopamine; Female; Male; Mice; Motor Activity; Naphthalenes; Piperidines; Rats; Receptors, Dopamine; Tetrahydronaphthalenes | 1981 |
Drugs acting on dopamine receptors: usefulness of a peripheral blocker in Parkinson's disease.
Topics: Apomorphine; Behavior; Benzimidazoles; Domperidone; Double-Blind Method; Drug Interactions; Female; Humans; Male; Middle Aged; Parkinson Disease; Piperidines; Receptors, Dopamine | 1980 |
The antiemetic effects of domperidone, a novel potent gastrokinetic.
Topics: Animals; Antiemetics; Apomorphine; Avoidance Learning; Benzimidazoles; Dogs; Domperidone; Female; Lethal Dose 50; Male; Piperidines | 1980 |
3H-apomorphine labels both dopamine postsynaptic receptors and autoreceptors.
Topics: Apomorphine; Benzimidazoles; Corpus Striatum; Domperidone; Kinetics; Neurons; Piperidines; Receptors, Dopamine; Synaptic Membranes | 1980 |
A role for dopamine in growth hormone regulation in the dog.
Topics: Animals; Apomorphine; Atropine; Benzimidazoles; Dogs; Domperidone; Dopamine; Female; Growth Hormone; Haloperidol; Isoquinolines; Kinetics; Male; Nomifensine; Phentolamine; Pimozide; Piperidines | 1981 |
The CB1 cannabinoid receptor antagonist SR 141716A affects A9 dopamine neuronal activity in the rat.
Topics: Amphetamine; Animals; Apomorphine; Dopamine; Dopamine Agents; Dopamine Agonists; Electrophysiology; Male; Mesencephalon; Neurons; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1995 |
Dopamine receptor agonist potencies for inhibition of cell firing correlate with dopamine D3 receptor binding affinities.
Topics: Aminoquinolines; Animals; Apomorphine; Azepines; Benzothiazoles; Binding, Competitive; CHO Cells; Cricetinae; Dopamine Agonists; Dose-Response Relationship, Drug; Ergolines; Imidazoles; Male; Neurons; Phenethylamines; Piperidines; Pramipexole; Quinolines; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Structure-Activity Relationship; Substantia Nigra; Tetrahydronaphthalenes; Thiazoles; Thiophenes; Transfection | 1995 |
Occupancy of central neurotransmitter receptors by risperidone, clozapine and haloperidol, measured ex vivo by quantitative autoradiography.
Topics: Animals; Antipsychotic Agents; Apomorphine; Autoradiography; Behavior, Animal; Clozapine; Guinea Pigs; Haloperidol; In Vitro Techniques; Iodine Radioisotopes; Isoxazoles; Male; Mescaline; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Neurotransmitter; Receptors, Serotonin; Risperidone; Stereotyped Behavior | 1993 |
Is it possible to predict the clinical effects of neuroleptics from animal data? Part V: From haloperidol and pipamperone to risperidone.
Topics: Amphetamine; Animals; Antipsychotic Agents; Apomorphine; Butyrophenones; Dogs; Dopamine D2 Receptor Antagonists; Haloperidol; Humans; In Vitro Techniques; Isoxazoles; Lysergic Acid Diethylamide; Motor Activity; Neostriatum; Oxygen Consumption; Piperidines; Rats; Risperidone; Schizophrenia; Serotonin Antagonists; Species Specificity; Tryptamines | 1994 |
Regional brain distribution of risperidone and its active metabolite 9-hydroxy-risperidone in the rat.
Topics: Animals; Antiemetics; Antipsychotic Agents; Apomorphine; Brain; Dogs; Half-Life; Injections, Subcutaneous; Isoxazoles; Male; Neurotransmitter Uptake Inhibitors; Norepinephrine; Organ Size; Paliperidone Palmitate; Piperidines; Pyrimidines; Rats; Rats, Wistar; Receptors, Neurotransmitter; Risperidone; Spectrophotometry, Ultraviolet; Tryptamines | 1994 |
Effects of atypical antipsychotic agents on social behavior in rodents.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Apomorphine; Benzazepines; Catalepsy; Chlorpromazine; Clozapine; Diazepam; Haloperidol; Isoxazoles; Male; Mice; Mice, Inbred Strains; Piperidines; Raclopride; Radioligand Assay; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Serotonin; Risperidone; Salicylamides; Social Behavior | 1993 |
3-[[(Aryloxy)alkyl]piperidinyl]-1,2-benzisoxazoles as D2/5-HT2 antagonists with potential atypical antipsychotic activity: antipsychotic profile of iloperidone (HP 873).
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Dopamine Antagonists; In Vitro Techniques; Isoxazoles; Male; Piperidines; Rats; Rats, Wistar; Receptors, Dopamine; Receptors, Serotonin; Serotonin Antagonists; Structure-Activity Relationship | 1995 |
Dopamine D2 autoreceptors in rats are behaviorally functional at 21 but not 10 days of age.
Topics: Aging; Aminoquinolines; Animals; Apomorphine; Azepines; Behavior, Animal; Benzothiazoles; Dopamine Agonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Male; Motor Activity; Piperidines; Pramipexole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Thiazoles | 1994 |
Behavioral and neurochemical data suggest functional differences between dopamine D2 and D3 receptors.
Topics: Analysis of Variance; Animals; Apomorphine; Benzothiazoles; CHO Cells; Cricetinae; Cricetulus; Dihydroxyphenylalanine; Dopamine Agonists; Dose-Response Relationship, Drug; Ergolines; Male; Microdialysis; Mitogens; Motor Activity; Piperidines; Pramipexole; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Tetrahydronaphthalenes; Thiazoles; Transfection | 1994 |
Effects of NPC16377, a potent and selective sigma receptor ligand, on the activity of mesencephalic dopamine-containing neurons in the rat.
Topics: Action Potentials; Animals; Antipsychotic Agents; Apomorphine; Dextroamphetamine; Dopamine; Flavonoids; Male; Mesencephalon; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, sigma | 1994 |
Two inbred rat sublines that differ in spontaneous yawning behavior also differ in their responses to cholinergic and dopaminergic drugs.
Topics: Animals; Apomorphine; Dopamine Agents; Dose-Response Relationship, Drug; Male; Parasympathomimetics; Physostigmine; Pilocarpine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic; Receptors, Dopamine; Species Specificity; Yawning | 1993 |
Thioperamide, the selective histamine H3 receptor antagonist, attenuates stimulant-induced locomotor activity in the mouse.
Topics: Amphetamine; Animals; Apomorphine; Central Nervous System Stimulants; Cocaine; Histamine Agonists; Histamine Antagonists; Male; Methylhistamines; Mice; Motor Activity; Piperidines | 1994 |
Enantioselective inhibition of apomorphine-induced emesis in the ferret by the neurokinin1 receptor antagonist CP-99,994.
Topics: Animals; Apomorphine; Dose-Response Relationship, Drug; Ferrets; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Stereoisomerism; Vomiting | 1994 |
Comparative study of 2-(4-ethyl-1-piperazinyl)-4-(fluorophenyl)-5,6,7,8,9, 10-hexahydrocycloocta[b]pyridine (AD-5423) and haloperidol for their pharmacological activities related to antipsychotic efficacy and/or adverse side-effects.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Body Temperature; Brain; Drug Synergism; Haloperidol; Male; Piperazines; Piperidines; Rats; Rats, Wistar; Receptors, Dopamine; Veratrine | 1993 |
NPC 16377, a potent and selective sigma-ligand. II. Behavioral and neuroprotective profile.
Topics: Amphetamine; Animals; Antipsychotic Agents; Apomorphine; Avoidance Learning; Brain; Flavonoids; Hypoxia; Lethal Dose 50; Male; Mice; Motor Activity; Nervous System; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, sigma | 1993 |
Ex vivo studies with iloperidone (HP 873), a potential atypical antipsychotic with dopamine D2/5-hydroxytryptamine2 receptor antagonist activity.
Topics: Animals; Antipsychotic Agents; Apomorphine; Autoradiography; Brain; Dihydroxyphenylalanine; Dopamine Antagonists; Isoxazoles; Male; Piperidines; Rats; Rats, Wistar; Serotonin Antagonists | 1996 |
Mixed D2/5-HT2 antagonism differentially affects apomorphine- and amphetamine-induced stereotyped behavior.
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Fluorobenzenes; Male; Piperidines; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Stereotyped Behavior | 1997 |
Effects of phencyclidine (PCP) and (+)MK-801 on sensorimotor gating in CD-1 mice.
Topics: Acoustic Stimulation; Animals; Apomorphine; Clozapine; Dextroamphetamine; Dizocilpine Maleate; Dopamine Agonists; Dose-Response Relationship, Drug; Haloperidol; Male; Mice; Mice, Inbred Strains; Phencyclidine; Piperidines; Rats; Receptors, sigma; Reflex, Startle; Species Specificity | 1998 |
GR205171 blocks apomorphine and amphetamine-induced conditioned taste aversions.
Topics: Amphetamines; Animals; Apomorphine; Avoidance Learning; Conditioning, Classical; Neurokinin-1 Receptor Antagonists; Ondansetron; Piperidines; Rats; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin Antagonists; Taste; Tetrazoles | 1998 |
The tachykinin NK1 receptor antagonist GR205171 abolishes the retching activity of neurons comprising the central pattern generator for vomiting in dogs.
Topics: Animals; Antiemetics; Apomorphine; Decerebrate State; Dogs; Electric Stimulation; Emetics; Female; Male; Neurokinin-1 Receptor Antagonists; Neurons; Piperidines; Reticular Formation; Tetrazoles; Vagus Nerve; Vomiting | 1999 |
Subthalamic nucleus microinjections of 5-HT2 receptor antagonists suppress stereotypy in rats.
Topics: Animals; Apomorphine; Behavior, Animal; Clozapine; Ergolines; Fluorobenzenes; Male; Mastication; Microinjections; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Antagonists; Stereotypic Movement Disorder; Subthalamic Nucleus | 2000 |
Auditory responses from the frontal cortex in the mustached bat, Pteronotus parnellii.
Topics: Animals; Apomorphine; Behavior, Animal; Clozapine; Ergolines; Fluorobenzenes; Male; Mastication; Microinjections; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Antagonists; Stereotypic Movement Disorder; Subthalamic Nucleus | 2000 |
Motor effects of (-)-OSU6162 in primates with unilateral 6-hydroxydopamine lesions.
Topics: Adamantane; Animals; Apomorphine; Benzazepines; Benzopyrans; Callithrix; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; Levodopa; Male; Motor Activity; Oxidopamine; Parkinson Disease; Piperidines; Quinpirole; Rotation | 2000 |
SR 141716A, a CB1 cannabinoid receptor antagonist, potentiates the locomotor stimulant effects of amphetamine and apomorphine.
Topics: Amphetamine; Animals; Apomorphine; Central Nervous System Stimulants; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Synergism; Injections, Intraperitoneal; Male; Motor Activity; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1999 |
Influence of different histamine receptor agonists and antagonists on apomorphine-induced licking behavior in rat.
Topics: Animals; Apomorphine; Chlorpheniramine; Dimaprit; Diphenhydramine; Dopamine Agonists; Drug Interactions; Famotidine; Histamine; Histamine Agonists; Histamine Antagonists; Imidazoles; Male; Piperidines; Ranitidine; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Thiourea; Toluidines | 2000 |
Mechanisms of inverse agonism of antipsychotic drugs at the D(2) dopamine receptor: use of a mutant D(2) dopamine receptor that adopts the activated conformation.
Topics: 1-Methyl-3-isobutylxanthine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Apomorphine; Binding, Competitive; Bromocriptine; Butaclamol; Chlorpromazine; CHO Cells; Clozapine; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; GTP-Binding Proteins; Haloperidol; Humans; Macromolecular Substances; Mutagenesis, Site-Directed; Phenethylamines; Piperidines; Protein Binding; Protein Conformation; Radioligand Assay; Receptors, Dopamine D2; Recombinant Fusion Proteins; Sodium; Spiperone; Structure-Activity Relationship; Sulpiride; Transfection; Tyramine | 2001 |
The anti-emetic action of the neurokinin(1) receptor antagonist CP-99,994 does not require the presence of the area postrema in the dog.
Topics: Animals; Antiemetics; Apomorphine; Chemoreceptor Cells; Copper Sulfate; Denervation; Dogs; Emetics; Fourth Ventricle; Male; Medulla Oblongata; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Solitary Nucleus; Vagus Nerve; Visceral Afferents; Vomiting | 2001 |
The selective neurokinin (NK)(1) antagonist, GR205,171, stereospecifically enhances mesocortical dopaminergic transmission in the rat: a combined dialysis and electrophysiological study.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; Antiemetics; Apomorphine; Depression; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Extracellular Space; Isomerism; Male; Microdialysis; Neural Pathways; Neurokinin-1 Receptor Antagonists; Piperidines; Prefrontal Cortex; Presynaptic Terminals; Rats; Rats, Wistar; Receptors, Neurokinin-1; Serotonin Receptor Agonists; Synaptic Transmission; Tetrazoles; Up-Regulation; Ventral Tegmental Area | 2002 |
Synthesis and structure-activity relationship of the isoindolinyl benzisoxazolpiperidines as potent, selective, and orally active human dopamine D4 receptor antagonists.
Topics: Administration, Oral; Animals; Apomorphine; Benzyl Compounds; Dizocilpine Maleate; Dopamine D2 Receptor Antagonists; Indoles; Infusions, Parenteral; Isoxazoles; Piperidines; Prazosin; Rats; Receptors, Dopamine D4; Serine; Spiperone; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity | 2002 |
Effects of cannabinoid receptor ligands on psychosis-relevant behavior models in the rat.
Topics: Animals; Antipsychotic Agents; Apomorphine; Arousal; Attention; Behavior, Animal; Cyclohexanols; Dextroamphetamine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hallucinogens; Male; Motor Activity; Piperidines; Psychoses, Substance-Induced; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Reflex, Startle; Rimonabant; Stereotyped Behavior | 2003 |
Potentiation of penile erection and yawning responses to apomorphine by cannabinoid receptor antagonist in rats.
Topics: Animals; Apomorphine; Brain; Cannabinoid Receptor Antagonists; Cannabinoids; Dopamine; Dopamine Agonists; Dronabinol; Drug Synergism; Male; Neural Pathways; Neurons; Penile Erection; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Rimonabant; Up-Regulation; Yawning | 2003 |
Antiparkinsonian activity of Ro 25-6981, a NR2B subunit specific NMDA receptor antagonist, in animal models of Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Apomorphine; Callithrix; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Synergism; Levodopa; Male; Motor Activity; Oxidopamine; Parkinsonian Disorders; Phenols; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2004 |
The effect of SR 141716 and apomorphine on sensorimotor gating in Swiss mice.
Topics: Animals; Apomorphine; Drug Combinations; Male; Mice; Piperidines; Psychomotor Performance; Pyrazoles; Reflex, Startle; Rimonabant | 2004 |
Intranigral injection of the H3 agonist immepip and systemic apomorphine elicit ipsilateral turning behaviour in naive rats, but reduce contralateral turning in hemiparkinsonian rats.
Topics: Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Functional Laterality; Histamine Agonists; Histamine Antagonists; Imidazoles; Male; Motor Activity; Oxidopamine; Piperidines; Rats; Rats, Wistar; Stereotyped Behavior; Substantia Nigra | 2004 |
Distinct temporal phases in the behavioral pharmacology of LSD: dopamine D2 receptor-mediated effects in the rat and implications for psychosis.
Topics: Amphetamine; Amphetamines; Animals; Apomorphine; Behavior, Animal; Cues; Discrimination Learning; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Fluorobenzenes; Hallucinogens; Haloperidol; Indans; Injections, Intraperitoneal; Lysergic Acid Diethylamide; Male; Piperidines; Psychotic Disorders; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Serotonin Antagonists; Serotonin Receptor Agonists; Time Factors | 2005 |
The substituted (S)-3-phenylpiperidine (-)-OSU6162 reduces apomorphine- and amphetamine-induced behaviour in Cebus apella monkeys.
Topics: Amphetamine; Animals; Apomorphine; Cebus; Dose-Response Relationship, Drug; Male; Piperidines; Stereotyped Behavior | 2006 |
Preclinical pharmacology of F-98214-TA, a novel potent serotonin and norepinephrine uptake inhibitor with antidepressant and anxiolytic properties.
Topics: Adrenergic Uptake Inhibitors; Animals; Anti-Anxiety Agents; Antidepressive Agents; Apomorphine; Dose-Response Relationship, Drug; Fluoxetine; Male; Mice; Motor Activity; Norepinephrine; Piperidines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin | 2005 |
Actions of novel antipsychotic agents on apomorphine-induced PPI disruption: influence of combined serotonin 5-HT1A receptor activation and dopamine D2 receptor blockade.
Topics: Aminopyridines; Animals; Antipsychotic Agents; Apomorphine; Dioxanes; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Male; Piperazines; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Serotonin 5-HT1 Receptor Agonists; Serotonin Antagonists; Serotonin Receptor Agonists; Tropanes | 2006 |
Iloperidone reduces sensorimotor gating deficits in pharmacological models, but not a developmental model, of disrupted prepulse inhibition in rats.
Topics: Acoustic Stimulation; Adrenergic alpha-Agonists; Analysis of Variance; Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Excitatory Amino Acid Antagonists; Gait Disorders, Neurologic; Imidazoles; Isoxazoles; Male; Neural Inhibition; Phencyclidine; Piperidines; Rats; Rats, Sprague-Dawley; Reflex, Startle | 2006 |
Antipsychotic-like profile of thioperamide, a selective H3-receptor antagonist in mice.
Topics: Amphetamine; Animals; Antipsychotic Agents; Apomorphine; Catalepsy; Dose-Response Relationship, Drug; Haloperidol; Histamine Agonists; Histamine Antagonists; Methylhistamines; Mice; Models, Animal; Motor Activity; Piperidines; Receptors, Histamine H3; Schizophrenia; Stereotyped Behavior; Time Factors | 2006 |
Galantamine and donepezil attenuate pharmacologically induced deficits in prepulse inhibition in rats.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Dizocilpine Maleate; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Gait Disorders, Neurologic; Galantamine; Indans; Inhibition, Psychological; Male; Nootropic Agents; Piperidines; Rats; Reflex, Startle; Scopolamine | 2007 |
Galantamine and donepezil differently affect isolation rearing-induced deficits of prepulse inhibition in mice.
Topics: Aconitine; Acoustic Stimulation; alpha7 Nicotinic Acetylcholine Receptor; Analysis of Variance; Animals; Animals, Outbred Strains; Apomorphine; Behavior, Animal; Cholinesterase Inhibitors; Dizocilpine Maleate; Donepezil; Dose-Response Relationship, Drug; Galantamine; Indans; Male; Mecamylamine; Mice; Neural Inhibition; Nicotinic Antagonists; Piperidines; Receptors, Nicotinic; Reflex, Startle; Risperidone; Social Isolation | 2008 |
Involvement of subthalamic nucleus in the stimulatory effect of Delta(9)-tetrahydrocannabinol on dopaminergic neurons.
Topics: Action Potentials; Analysis of Variance; Animals; Apomorphine; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Dronabinol; Excitatory Amino Acid Agonists; Ibotenic Acid; Kynurenic Acid; Male; Neurons; Piperidines; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Substantia Nigra; Subthalamic Nucleus | 2008 |
Apomorphine-induced turning behavior in 6-hydroxydopamine lesioned rats is increased by histidine and decreased by histidine decarboxylase, histamine H1 and H2 receptor antagonists, and an H3 receptor agonist.
Topics: Animals; Apomorphine; Basal Ganglia; Enzyme Inhibitors; Histamine Agonists; Histamine H1 Antagonists; Histamine H2 Antagonists; Histidine; Histidine Decarboxylase; Imidazoles; Injections, Intraventricular; Male; Methylhistidines; Narcotic Antagonists; Oxidopamine; Piperidines; Pyrilamine; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Sympatholytics; Synapses; Thiourea | 2008 |
Galantamine improves apomorphine-induced deficits in prepulse inhibition via muscarinic ACh receptors in mice.
Topics: Acetylcholine; Acoustic Stimulation; Animals; Animals, Outbred Strains; Apomorphine; Behavior, Animal; Benzazepines; Cholinesterase Inhibitors; Donepezil; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Galantamine; Indans; Inhibition, Psychological; Male; Mecamylamine; Mice; Microdialysis; Muscarinic Agonists; Muscarinic Antagonists; Nicotinic Antagonists; Oxotremorine; Piperidines; Pirenzepine; Prefrontal Cortex; Receptors, Muscarinic; Reflex, Startle; Serotonin | 2009 |
Using prepulse inhibition to detect functional D3 receptor antagonism: effects of WC10 and WC44.
Topics: Animals; Antipsychotic Agents; Apomorphine; Benzothiazoles; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Indoles; Male; Piperazines; Piperidines; Pramipexole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D3; Reflex, Startle | 2009 |
Effects of cannabinoids infused into the dorsal hippocampus upon memory formation in 3-days apomorphine-treated rats.
Topics: Animals; Apomorphine; Avoidance Learning; Benzazepines; Benzoxazines; Cannabinoids; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Hippocampus; Male; Memory; Mental Recall; Morpholines; Naphthalenes; Neuropsychological Tests; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Sulpiride; Time Factors | 2009 |
Synthesis and dopaminergic activity of some E-3-(piperidin-1-yl)-1-(4-substituted phenyl)prop-2-en-1-one derivatives.
Topics: Alkenes; Animals; Apomorphine; Behavior, Animal; Dopamine Agonists; Ketones; Piperidines | 2009 |
Modulation of prepulse inhibition and stereotypies in rodents: no evidence for antipsychotic-like properties of histamine H3-receptor inverse agonists.
Topics: Animals; Antipsychotic Agents; Apomorphine; Benzofurans; Dizocilpine Maleate; Drug Inverse Agonism; Haloperidol; Histamine Antagonists; Imidazoles; Inhibition, Psychological; Male; Methamphetamine; Mice; Phencyclidine; Piperidines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reflex, Startle; Stereotyped Behavior | 2010 |
Pharmacological blockade of dopamine D2 receptors by aripiprazole is not associated with striatal sensitization.
Topics: Animals; Apomorphine; Aripiprazole; Buffers; Catalepsy; Cell Membrane; Cerebral Cortex; Corpus Striatum; Domperidone; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Drug Antagonism; Drug Partial Agonism; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Hippocampus; Male; Piperazines; Piperidines; Pyridines; Quinolones; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin 5-HT1 Receptor Antagonists; Stereotyped Behavior; Up-Regulation | 2011 |
Pharmacology of JNJ-37822681, a specific and fast-dissociating D2 antagonist for the treatment of schizophrenia.
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Benzodiazepines; Brain; Catalepsy; Cells, Cultured; CHO Cells; Cricetinae; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Female; Haloperidol; Humans; Ligands; Locomotion; Male; Olanzapine; Piperidines; Prolactin; Pyridazines; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Dopamine D2; Schizophrenia; Serotonin | 2012 |
Anti-apoptotic and anti-inflammatory effect of Piperine on 6-OHDA induced Parkinson's rat model.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Apomorphine; Apoptosis; Behavior, Animal; Benzodioxoles; Disease Models, Animal; Male; Oxidative Stress; Oxidopamine; Parkinson Disease; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Wistar | 2013 |
Synthesis and evaluation of a series of piperidine-2,6-dione-piperazine (piperidine) derivatives as multireceptor atypical antipsychotics.
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Clozapine; Disease Models, Animal; Dizocilpine Maleate; Mice; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Histamine H1; Receptors, Serotonin; Structure-Activity Relationship | 2012 |
SSR504734 enhances basal expression of prepulse inhibition but exacerbates the disruption of prepulse inhibition by apomorphine.
Topics: Amphetamine; Animals; Apomorphine; Benzamides; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Glycine; Glycine Plasma Membrane Transport Proteins; Male; Mice; Mice, Inbred C57BL; Piperidines; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Sensory Gating | 2013 |
Complex interaction between anandamide and the nitrergic system in the dorsolateral periaqueductal gray to modulate anxiety-like behavior in rats.
Topics: Animals; Anxiety; Apomorphine; Arachidonic Acids; Bicuculline; Cannabinoid Receptor Agonists; Disease Models, Animal; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; GABA-A Receptor Antagonists; Male; Maze Learning; Nitric Oxide Synthase; Oxadiazoles; Periaqueductal Gray; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Quinoxalines; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2013 |
Behavioral effects of clozapine, pimavanserin, and quetiapine in rodent models of Parkinson's disease and Parkinson's disease psychosis: evaluation of therapeutic ratios.
Topics: Amphetamine; Animals; Antiparkinson Agents; Antipsychotic Agents; Apomorphine; Clozapine; Dopamine; Dose-Response Relationship, Drug; Male; Parkinsonian Disorders; Piperidines; Psychotic Disorders; Quetiapine Fumarate; Rats; Rats, Sprague-Dawley; Urea | 2013 |
Feeding condition and the relative contribution of different dopamine receptor subtypes to the discriminative stimulus effects of cocaine in rats.
Topics: Animals; Apomorphine; Benzamides; Cocaine; Conditioning, Operant; Discrimination, Psychological; Dopamine Agonists; Dopamine Antagonists; Dopamine Uptake Inhibitors; Electroshock; Food Deprivation; Indoles; Lisuride; Male; Piperidines; Pyridines; Quinpirole; Raclopride; Rats, Sprague-Dawley; Reinforcement, Psychology | 2014 |
Comparison of automated home-cage monitoring systems: emphasis on feeding behaviour, activity and spatial learning following pharmacological interventions.
Topics: Animals; Apomorphine; Cholinergic Antagonists; Dopamine Agonists; Dose-Response Relationship, Drug; Electronic Data Processing; Excitatory Amino Acid Antagonists; Exploratory Behavior; Feeding Behavior; Female; History, 20th Century; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Monitoring, Physiologic; Motor Activity; Phencyclidine; Piperidines; Pyrazoles; Scopolamine; Spatial Learning | 2014 |
Intranigral administration of substance P receptor antagonist attenuated levodopa-induced dyskinesia in a rat model of Parkinson's disease.
Topics: Adrenergic Agents; Animals; Antiparkinson Agents; Apomorphine; Disease Models, Animal; Dopamine; Dopamine Agonists; Drug Administration Schedule; Dyskinesia, Drug-Induced; Gene Expression Regulation; Indoles; Levodopa; Male; MAP Kinase Signaling System; Motor Activity; Neurokinin-1 Receptor Antagonists; Oxidopamine; Parkinson Disease; Piperidines; Rats; Rats, Sprague-Dawley; Substantia Nigra; Time Factors | 2015 |
Atypical antipsychotic properties of AD-6048, a primary metabolite of blonanserin.
Topics: Animals; Antipsychotic Agents; Apomorphine; Basal Ganglia Diseases; Behavior, Animal; Catalepsy; Corpus Striatum; Dose-Response Relationship, Drug; Gene Expression; Haloperidol; Injections, Subcutaneous; Male; Mice; Nucleus Accumbens; Oncogene Proteins v-fos; Piperazines; Piperidines; Pyridines | 2015 |