apomorphine has been researched along with oxidopamine in 702 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 182 (25.93) | 18.7374 |
| 1990's | 221 (31.48) | 18.2507 |
| 2000's | 151 (21.51) | 29.6817 |
| 2010's | 131 (18.66) | 24.3611 |
| 2020's | 17 (2.42) | 2.80 |
| Authors | Studies |
|---|---|
| Kunow, M; Löschmann, PA; Wachtel, H | 2 |
| Baraban, JM; Bhat, RV; Cole, AJ; Worley, PF | 1 |
| Hong, JS; Pennypacker, KR; Ye, H; Zhang, WQ | 1 |
| Björklund, A; Cenci, MA; Kalén, P; Mandel, RJ; Wictorin, K | 1 |
| Kohsaka, S; Nagatsu, T; Tsuzaki, N; Uchida, K | 1 |
| Blunt, S; Jenner, P; Marsden, CD; Sawada, T; Takeuchi, Y | 1 |
| Agnati, LF; Carani, C; Cintra, A; Fuxe, K; Li, XM; Merlo Pich, E; O'Connor, WT; Tanganelli, S; Tinner, B; Von Euler, G | 1 |
| Huang, KX; Jin, GZ; Sun, BC | 1 |
| Blunt, SB; Jenner, P; Marsden, CD | 3 |
| Matsuda, S; Nishiyama, N; Saito, H | 1 |
| Jones, GH; Robbins, TW | 1 |
| Abrams, DR; Bruno, JP | 1 |
| Weissenborn, R; Winn, P | 1 |
| Carey, RJ; Damianopoulos, EN | 1 |
| Cadet, JL; Zhu, SM | 1 |
| Björklund, A; Cenci, MA; Mandel, RJ; Wictorin, K | 1 |
| Chesselet, MF; Gonzales, C; Soghomonian, JJ | 1 |
| Hu, XT; White, FJ | 1 |
| Borrelli, E; Haby, C; Hindelang, C; Lisovoski, F; Revel, MO; Schleef, C; Zwiller, J | 1 |
| Bourdelais, A; Kalivas, PW | 1 |
| Bluemink, GJ; Van Ree, JM; Vos, PE; Wolterink, G | 1 |
| Doherty, M; Gratton, A | 1 |
| Harsing, LG; Vizi, ES | 1 |
| LaHoste, GJ; Marshall, JF | 1 |
| Carman, LS; Gage, FH; Shults, CW | 1 |
| Ebner, TJ; Friehs, GM; Haines, SJ; He, LS; Parker, RG; Turner, DA | 1 |
| Silverman, PB | 6 |
| McKenzie, JS; Shafton, AD; Stewart, CA | 1 |
| Bickford-Wimer, P; Strömberg, I | 1 |
| Bennett, JP; Orosz, D | 1 |
| Aebischer, P; Sagen, J; Tresco, PA; Winn, SR | 1 |
| Bédard, PJ; Di Paolo, T; Gagnon, C; Gaudin, DP; Rioux, L | 1 |
| Carey, RJ | 7 |
| Dillon, L; Hjorth, S; Mason, DW; McRae, A; Tice, TR | 1 |
| Ikegami, A; Ozaki, A; Sukamoto, T; Yamashita, A; Yoshidomi, M | 1 |
| Bervoets, K; Mavridis, M; Millan, MJ | 1 |
| Burton, S; Daya, S; Potgieter, B | 1 |
| Szmigielski, A; Zalewska-Kaszubska, J | 1 |
| Cozzolino, A; Di Chiara, G; Fenu, S; Morelli, M | 1 |
| Joyce, JN; Neal, BS | 1 |
| Gale, K; Meloni, R | 2 |
| Brown, SJ; Evenden, JL; Gill, R; Iversen, SD; Richardson, PJ | 1 |
| Blunt, S; Jenner, P; Marsden, CD | 1 |
| Kameyama, T; Katoh, A; Nabeshima, T | 1 |
| Bédard, PJ; Bui, LK; DiPaolo, T; Gaudin, DP; Grégoire, L; Rioux, L | 1 |
| Fink, H; Morgenstern, R; Ott, T | 1 |
| Hoffer, B; Olson, L; Strömberg, I; van Horne, CG; Young, D | 1 |
| Kiss, J; Lendvai, B; Sándor, A; Sándor, NT; Vizi, ES | 1 |
| Drucker-Colín, R; García-Hernández, F; Komisaruk, BR; Mendoza-Ramírez, JL; Pacheco-Cano, MT | 1 |
| Hong, JS; Jiang, HK; McGinty, JF | 1 |
| Kerkerian, L; Nieoullon, A; Salin, P | 2 |
| Hong, JS; Hudson, PM; Jiang, HK; Li, SJ; Nanry, K; Owyang, V; Stachowiak, MS; Tilson, HA | 1 |
| Burke, RE; Cadet, JL; Jackson-Lewis, V; Karanas, AL; Kent, JD | 1 |
| Eneroth, P; Fuxe, K; Hökfelt, T; Meister, B; von Euler, G | 1 |
| Abrous, N; Aunis, D; Decombe, R; Herman, JP; Peschanski, M; Rivot, JP | 1 |
| Clarke, PB; Fibiger, HC; Jakubovic, A; Wyder, KJ | 1 |
| Bagnoli, P; Buonamici, M; Cervini, MA; Raffaelli, A; Rossi, AC; Sebastiani, L | 1 |
| Dymecki, J; Freed, WJ | 1 |
| Arbuthnott, GW; MacLeod, NK; Ryman, A | 1 |
| Abrous, N; Choulli, K; Herman, JP; Le Moal, M; Simon, H | 1 |
| Becker, JB; Curran, EJ; Freed, WJ; Poltorak, M | 1 |
| Furuyama, F; Hashitani, T; Hida, H; Ishida, Y; Isobe, Y; Kumazaki, M; Makino, T; Nishino, H; Sakurai, T; Sato, H | 1 |
| Annett, LE; Baker, HF; Dunnett, SB; Marsden, CD; Martel, FL; Ridley, RM; Rogers, DC | 1 |
| Kuramoto, S; Ohtsuru, K; Torigoe, R; Yoshida, M | 1 |
| Hildebrand, JP; Kolmonpunporn, M; Lehman, MN; Moody, CA; Norman, AB; Sanberg, PR; Wyatt, LM | 1 |
| Van Ree, JM; Van Zanten, E; Wolterink, G | 1 |
| Di Chiara, G; Morelli, M | 1 |
| Ceresoli, G; Groppetti, A; Mandelli, V; Parenti, M | 1 |
| Kozak, W; Puciłowski, O; Valzelli, L | 1 |
| Barroso, J; Castellano, MA; Diaz-Palarea, MD; Rodriguez, M | 1 |
| Roberts, DC | 1 |
| Etemadzadeh, E; Kaakkola, S; Koskinen, L | 1 |
| Dunnett, SB; Rogers, DC | 1 |
| Aebischer, P; Tresco, PA; Wahlberg, L; Winn, SR | 1 |
| Gale, K; Meloni, R; Segovia, J | 1 |
| Koob, GF; Swerdlow, NR | 2 |
| Cadafalch, J; Casas, M; Ferré, S; Grau, JM; Jané, F | 1 |
| Brown, VJ; Dunnett, SB | 1 |
| Cadet, JL; Fahn, S; Jackson-Lewis, V; Thomas, J | 1 |
| Bankiewicz, KS; Ewing, SE; Perese, DA; Ulman, J; Viola, J | 1 |
| Costentin, J; Duterte-Boucher, D; Naudin, B | 1 |
| Dwork, A; Fahn, S; Flaster, E; Garcia de Yebenes, J; Herbert, J; Latov, N; Mena, MA; Slonim, D | 1 |
| Kastin, AJ; Kostrzewa, RM; White, TG; Zadina, JE | 1 |
| Fletcher, GH; Starr, MS | 3 |
| Ettenberg, A; Koob, GF; Weiss, F | 1 |
| Campastro, OJ; D'Anna, L; Fernández, RA; González, SA; Loidl, CF; Pecci-Saavedra, J; Soqueff, MN | 1 |
| Kuga, T; Moroi, K; Takashi, K | 1 |
| Arnt, J; Hyttel, J | 2 |
| Fukuda, T; Maruyama, Y; Morimoto, Y; Setoguchi, M; Shoji, H; Tsumagari, T | 1 |
| Pucilowski, O; Valzelli, L | 1 |
| Flauto, C; Groppetti, A; Parati, E; Parenti, M; Vescovi, A | 1 |
| French, ED | 1 |
| Dusticier, N; Kerkerian, L; Nieoullon, A | 1 |
| Kerkerian, L; Nieoullon, A | 1 |
| Arnt, J | 2 |
| Allikmets, L; Maimets, M; Nurk, A; Soosaar, A; Vasar, E | 1 |
| Fischer, W; Lasek, R; Müller, M | 1 |
| Flauto, C; Groppetti, A; Parati, E; Parenti, M; Rusconi, L; Vescovi, A | 1 |
| Amalric, M; Creese, I; Koob, GF; Swerdlow, NR | 1 |
| Walters, JR; Weick, BG | 1 |
| Petit, JY; Piriou, F; Welin, L | 1 |
| Fujiwara, M; Kataoka, Y; Ohta, H; Sakurai, Y; Shimazoe, T; Ueki, S | 1 |
| Cervo, L; Woolverton, WL | 1 |
| Herrera-Marschitz, M; Ungerstedt, U | 2 |
| Freedman, R; Hoffer, BJ; Johnson, SW | 1 |
| Offermeier, J; van Rooyen, JM | 2 |
| Christensen, NJ; Jensen, TS; Smith, DF | 1 |
| Buonamici, M; Khazan, N; Maj, R; Pagani, F; Rossi, AC | 1 |
| Weiss, B; Winkler, JD | 1 |
| Hiyama, Y; Sekihara, S; Suda, H; Terasawa, K; Watanabe, H | 1 |
| Fahn, S; Hassan, MN; Higgins, D; Traub, M | 1 |
| Cantrill, R; Ford, D; Mitchell, D; Phillips, S | 1 |
| Coward, DM | 2 |
| Biziere, K; Kan, JP; Wermuth, CG; Worms, P | 1 |
| Cury, M; González, M; Guzmán, F; Motles, E | 1 |
| Abe, Y; Kisara, K; Tadano, T; Yonezawa, A | 1 |
| Le Moal, M; Oades, RD; Rivet, JM; Simon, H; Taghzouti, K | 1 |
| Boismare, F; Daoust, M; Moore, N; Saligaut, C | 2 |
| Burunat, E; Castro, R; Díaz-Palarea, MD; Rodríguez, M | 2 |
| Amalric, M; Koob, GF; Swerdlow, NR | 1 |
| Dunnett, SB; Jones, GH; Rogers, DC; Whishaw, IQ | 1 |
| Martínez, JA; Milanés, MV; Vargas, ML | 1 |
| Hiyama, Y; Miura, K; Sugita, S; Tanaka, K; Terasawa, K; Watanabe, H | 1 |
| Thermos, K; Weiss, B; Winkler, JD | 1 |
| Dourish, CT; Iversen, SD; Stoessl, AJ | 1 |
| Björklund, A; Brundin, P; Londos, E; Strecker, RE | 1 |
| Harry, GJ; Hong, JS; Hudson, PM; Nanry, K; Tilson, HA | 1 |
| Casas, M; Herrera-Marschitz, M; Ungerstedt, U | 1 |
| Laping, NJ; Ramirez, VD | 1 |
| Szechtman, H; Ziegler, M | 1 |
| Bitran, D; Holmes, GM; Hull, EM; Lookingland, KJ | 1 |
| Hiyama, T; Kikuchi, T; Suzuki, S; Tsutsui, M; Yamada, K; Yasuda, Y | 1 |
| Carlsson, A; Hajos, M; Hjorth, S; Svensson, K | 1 |
| Baird, JL; Glick, SD; Hinds, PA | 1 |
| Delius, JD; Lindenblatt, U | 1 |
| Cadafalch, J; Casas, M; Cobos, A; Ferré, S; Grau, JM; Jané, F | 1 |
| Gold, LH; Koob, GF; Swerdlow, NR | 1 |
| Cadet, JL; de Yebenes, JG; Dwork, A; Fahn, S; Herbert, J; Jackson-Lewis, V; Pezzoli, G; Truong, DD | 1 |
| Dillon, DL; Hjorth, S; Mason, DW; McRae-Degueurce, A; Tice, TR | 1 |
| Radhakishun, FS; van Ree, JM; Wolterink, G | 1 |
| Altar, CA; Gerber, R; Hall, NR; Liebman, JM | 1 |
| Clarke, PB; Fibiger, HC; Jakubovic, A | 1 |
| Herrera-Marschitz, M; Ståhle, L; Tossman, U; Ungerstedt, U; Zetterström, T | 1 |
| Coates, G; Garnett, ES; Heyes, MP | 1 |
| Robbins, TW; Winn, P | 1 |
| Liskowsky, DR; Potter, LT | 1 |
| Mandel, RJ; Randall, PK | 1 |
| Forler, C; Palfreyman, MG; Robin, M | 1 |
| Abreu, P; Calzadilla, CH; Castro, R; Rodriguez, M | 1 |
| Chang, JP; Cook, AF; Marchant, TA; Nahorniak, CS; Peter, RE | 1 |
| Jenner, P; Kelly, E; Marsden, CD | 1 |
| Breese, GR; Mueller, RA; Napier, TC | 1 |
| Watanabe, H | 1 |
| Butler, WM; Dunbar, GL; Sabel, BA; Stein, DG | 1 |
| Koob, GF; Lee, D; Swerdlow, NR; Vaccarino, FJ | 1 |
| Johnston, S; Merali, Z; Sistek, J | 1 |
| Brecha, NC; Citron, MC; Erinoff, L; Rickman, DW | 1 |
| Dourish, CT; Hutson, PH | 1 |
| Roberts, DC; Vickers, G; Zito, KA | 1 |
| Forster, C; Herrera-Marschitz, M; Ungerstedt, U | 2 |
| Huston, JP; Morgan, S; Steiner, H | 1 |
| Fahn, S; Hassan, M; Jackson-Lewis, V; Traub, M; Wagner, HR | 1 |
| Kikuchi, T; Maeda-Hagiwara, M; Uramoto, H; Watanabe, H | 1 |
| Jackson, EA; Kelly, PH; Schultz, L | 1 |
| Feigenbaum, JJ; Yanai, J | 1 |
| Hsiao, S; Itoh, S; Katsuura, G | 1 |
| Koob, GF; Swanson, LW; Swerdlow, NR | 1 |
| Bjur, RA; Westfall, DP | 1 |
| Anderson, PS; Baldwin, JJ; Clineschmidt, BV; Hirshfield, JM; Jones, JH; Lundell, GF; Martin, GE; McClure, DE; Randall, WC; Williams, M | 1 |
| Alloway, KD; Rebec, GV | 1 |
| Szadowska, A; Szmigielska, H; Szmigielski, A | 1 |
| Cohen, R; Pert, A; Siever, L | 1 |
| Morgan, M; Smith, JR | 1 |
| Costall, B; Kelly, ME; Naylor, RJ | 2 |
| Andén, NE; Grabowska-Andén, M | 1 |
| Bendesky, RJ; Jones, JH; Martin, GE | 1 |
| Bonnet, JJ; Costentin, J; Protais, P | 1 |
| Costentin, J; Dubuc, I; Protais, P | 1 |
| Bollók, I; Penke, B; Telegdy, G; Varga, J; Vécsei, L | 1 |
| Dravid, A; Enz, A; Frei, P; Jaton, AL | 1 |
| Agnati, LF; Aldinio, C; Consolazione, A; Fuxe, K; Savoini, G; Toffano, G; Valenti, G | 1 |
| Geyer, MA; Lee, EH | 1 |
| Marshall, JF; Neve, KA | 1 |
| MacKenzie, RG; Zigmond, MJ | 1 |
| Almazan, G; Pacheco, P; Sourkes, TL | 1 |
| Bevan, P | 1 |
| Herrera-Marschitz, M; Hyttel, J; Ungerstedt, U | 1 |
| Dean, P; Redgrave, P | 1 |
| Kozlowski, MR; Marshall, JF; Neve, KA | 1 |
| Aguilar, R; Arbuthnott, G; Garcia-Munoz, M; Patino, P | 1 |
| Bacopoulos, NG; Schweitzer, BI | 1 |
| Arbuthnott, GW; Garcia-Munoz, M; Patino, P; Wright, AJ | 1 |
| Starr, MS; Summerhayes, M | 2 |
| Bloom, FE; Deyo, SN; Magistretti, PJ; Shoemaker, WJ; Staunton, DA | 1 |
| Fujiwara, M; Hori, Y; Kataoka, Y; Ueki, S | 1 |
| Herman, JP; Le Moal, M; Nadaud, D; Simon, H | 1 |
| Koob, GF; Robbins, TW; Roberts, DC | 1 |
| Ingvar, M; Lindvall, O; Stenevi, U | 1 |
| Korf, J; Sebens, JB; Vaalburg, W; van der Werf, JF | 1 |
| Baetge, G; Bloom, FE; Deyo, S; Ettenberg, A; Koda, L; Magistretti, PJ; Shoemaker, WJ; Staunton, DA | 1 |
| Schallert, T; Upchurch, M; Vaughn, DM; Wilcox, RE | 1 |
| Cubells, J; Gardner, EL; Hirschhorn, ID; Hittner, D; Makman, MH | 1 |
| Kelly, PH; Roberts, DC | 1 |
| Creese, I; Leff, S; Sibley, DR | 1 |
| Randall, PK; Severson, JA | 1 |
| Hall, MD; Jenner, P; Kelly, E; Marsden, CD | 1 |
| Carlsson, A | 1 |
| Bonnet, JJ; Costentin, J; Protais, P; Schwartz, JC | 1 |
| Concannon, JT; Schechter, MD | 1 |
| Gruenthal, M | 1 |
| Clineschmidt, BV; Jones, JH; Martin, GE; Pettibone, DJ; Williams, M; Yarbrough, GG | 1 |
| Korf, J; Sebens, JB; Van der Werf, JF | 1 |
| Lee, EK; Tamminga, CA; Walters, JR; Waszczak, BL | 1 |
| Herman, JP; Le Moal, M; Stinus, L | 1 |
| Fenton, HM; Gerhardt, S; Leszczak, E; Liebman, JM | 1 |
| Kurumiya, S; Olds, ME; Takeichi, T; Umemoto, M | 1 |
| Bhargava, HN; Ritzmann, RF | 1 |
| Joyce, EM; Koob, GF | 1 |
| Jenner, P; Leigh, PN; Marsden, CD; Reavill, C | 1 |
| Kaakkola, S; Männistö, P; Mattila, J | 1 |
| Jenner, P; Leigh, N; Marsden, CD; Reavill, C | 1 |
| Di Chiara, G; Imperato, A; Morelli, M; Porceddu, ML | 1 |
| Mitchell, I; Redgrave, P | 1 |
| Haubrich, DR; Martin, GE; Williams, M | 1 |
| Nomoto, T; Uchida, Y | 1 |
| Breese, GR; Lundberg, D; Mueller, RA | 1 |
| Koob, GF; Roberts, DC; Strecker, RE | 1 |
| Fibiger, HC; Phillips, AG; Spyraki, C | 1 |
| Bianchine, JR; Schwarz, RD; Uretsky, NJ | 1 |
| Anderson, GM; Cohen, DJ; Shaywitz, BA; Teicher, MH; Weldon, DA; Wool, RS | 1 |
| Fink, JS; Smith, GP | 1 |
| Chesselet, MF; Ciaramitaro, VM; Delfs, JM; Parry, TJ | 1 |
| Currie, RW; Paul, ML; Robertson, HA | 1 |
| Bédard, PJ; Côté, PY; Grégoire, L; Parent, A; Roy, E | 1 |
| Iamshchikova, NG; Shugalëv, NP; Stavrovskaia, AV | 1 |
| Gancher, S; Mayer, A | 1 |
| Guilarte, TR; May, CH; Vesper, J; Vogel, S; Wagner, HN; Woiciechowsky, C | 1 |
| Benazzouz, A; Bioulac, B; Burbaud, P; Coussemacq, M; Gross, C | 1 |
| Morgenstern, R; Reum, T; Schäfer, U | 1 |
| Hirose, T; Kikuchi, T; Miwa, T; Morita, S; Oshiro, Y; Tottori, K; Uwahodo, Y | 1 |
| Niles, LP; Tenn, CC | 1 |
| Biddle, PT; Bowenkamp, KE; Gerhardt, GA; Granholm, AC; Henry, MA; Hoffer, BJ; Hoffman, AF | 1 |
| Donaldson, D; Ferreira, M; Jackson-Lewis, V; Jiang, H; Levivier, M; Przedborski, S; Togasaki, DM | 1 |
| Boix, F; Fornaguera, J; Huston, JP; Schwarting, RK | 1 |
| Castello, ME; Costa, G; Dajas, F; Greenfield, S; Jerusalinsky, D; Levesque, D; Medina, J; Silveira, R | 1 |
| Herrera-Marschitz, M; Lindqvist, E; Luthman, J | 1 |
| Barnéoud, P; Castel, MN; Colin, P; Delaère, P; Horellou, P; Mallet, J; Perricaudet, M; Vigne, E | 1 |
| Björklund, A; Cunningham, MG; McKay, R; Nikkhah, G | 1 |
| Bentlage, C; Björklund, A; Nikkhah, G; Olsson, M | 1 |
| Badiani, A; Browman, KE; Robinson, TE | 1 |
| Misu, Y; Okumura, F; Sato, K; Ueda, H | 1 |
| Boyson, SJ; Fong, CS; Hoffer, BJ; Hudson, JL | 1 |
| During, MJ; Kaplitt, MG; Leone, P; O'Malley, KL; Pfaff, DW; Samulski, RJ; Xiao, X | 1 |
| Barker, R; Dunnett, SB | 1 |
| Chase, TN; Engber, TM; Kask, AM; Papa, SM | 1 |
| Richardson, PJ; Sirinathsinghji, DJ; Vellucci, SV | 1 |
| Klug, JM; Norman, AB | 1 |
| Gash, DM; Sakai, K | 1 |
| Bronstein, DM; Hong, JS; Hudson, PM; Pennypacker, KR; Ye, H | 1 |
| Morgenstern, R; Reum, T | 1 |
| Bräutigam, K; Morgenstern, R; Sohr, R | 1 |
| Dahlström, A; McRae, A | 1 |
| Kamei, H; Kameyama, T; Nabeshima, T | 1 |
| Beninger, RJ; Boegman, RJ; Colton, AM; Ingles, JL; Jhamandas, K | 1 |
| Huang, KX; Walters, JR | 1 |
| Gnanalingham, KK; Robertson, RG | 1 |
| Björklund, A; Cenci, MA; Duan, WM; Kalén, P | 1 |
| Hoffer, BJ; Hoffman, A; Hudson, JL; Moorhead, JW; Strömberg, I | 1 |
| Fisher, LJ; Gage, FH; Shimohama, S | 1 |
| Gurevich, V; Jiao, S; Wolff, JA | 1 |
| Burke, RE; Franklin, SO; Inturrisi, CE; Jones, SB; Zhu, YS | 1 |
| Albin, RL; Becker, JB; Curran, EJ | 1 |
| Björklund, A; Campbell, K; Cenci, MA | 2 |
| Asin, KE; Pitzer, MR; Wirtshafter, D | 1 |
| Fraser, A; Sullivan, RM; Szechtman, H | 1 |
| Hipkens, SB; Yurek, DM | 1 |
| Chritin, M; Feuerstein, C; Savasta, M | 1 |
| Björklund, A; Duan, WM; Jödicke, A; Knappe, U; Nikkhah, G | 1 |
| Björklund, A; Cenci, MA | 1 |
| Brock, S; Clayton, J; Gerhardt, GA; Hoffer, BJ; Hudson, JL; Masserano, J; Strömberg, I; van Horne, CG | 1 |
| Abrous, DN; Dunnett, SB; Torres, EM | 1 |
| Fujisawa, M; Hatase, O; Itano, T; Matsui, H; Miyamoto, O; Nagao, S; Negi, T; Tokuda, M | 1 |
| Nitsch, C; Schaefer, F; Scotti, AL; Unger, J; Wolfrum, G | 1 |
| Crocker, AD; Double, KL | 1 |
| Abrous, DN; Dunnett, SB; Shaltot, AR; Torres, EM | 1 |
| Fisher, H; Johnson, SK; Wagner, GC | 1 |
| Parker, BA; Sullivan, RM; Szechtman, H | 1 |
| Eblen, F; Kockgether, T; Löschmann, PA; Wachtel, H; Wüllner, U | 1 |
| Laprade, N; Radja, F; Reader, TA; Soghomonian, JJ | 1 |
| Abrous, DN; Le Moal, M; Simon, H | 1 |
| Guerra, MJ; Labandeira-Garcia, JL; Liste, I; Lopez-Martin, E; Rozas, G | 1 |
| Kimber, T; Martin, D; Shults, CW | 1 |
| Bickford, P; Strömberg, I | 1 |
| Kameyama, T; Toyoshi, T; Ukai, M | 1 |
| Jin, GZ; Sun, BC; Zhang, XX | 1 |
| Johnson, RG; Lindqvist, E; Luthman, J; Rose, GM; Stevens, KE | 1 |
| Granata, R; Jenner, P; Laboyrie, PM; Marsden, CD; Quinn, NP; Wenning, GK | 1 |
| Drucker-Colín, R; Durán-Vázquez, A; Jiménez-Anguiano, A; Mendoza-Ramírez, JL; Salín-Pascual, RJ; Verdugo-Díaz, L | 1 |
| Gancher, S; Mayer, A; Youngman, S | 2 |
| Carta, A; Di Chiara, G; Fenu, S; Morelli, M | 1 |
| Barnéoud, P; Boireau, A; Doble, A; Dubédat, P; Mazadier, M; Miquet, JM; Parmentier, S | 1 |
| Boldry, RC; Chase, TN; Engber, TM; Kask, AM; Papa, SM | 1 |
| Johnson, RL; Mishra, RK; Ott, MC | 1 |
| Sket, D; Sprah, L; Zivin, M | 1 |
| Böhme, V; Moser, A; Nobbe, F; Siebecker, F | 1 |
| van Ree, JM; Vos, PE; Wolterink, G | 1 |
| Dixon, AK; Gull, P; Hoyer, D; Jaton, AL; Kalkman, HO; Markstein, R; Rüdeberg, C; Urwyler, S | 1 |
| Labandeira García, JL; Rozas, G | 1 |
| Besson, MJ; Durand, C; Herve, D; Penit-Soria, J | 1 |
| Brotchie, JM; Duty, S | 1 |
| Fink, JS; Pollack, AE; Turgeon, SM | 1 |
| Cui, WY; Gao, ZG; Liu, CG | 1 |
| Heneka, MT; Klockgether, T; Kunow, M; Löschmann, PA; Schulz, JB; Wachtel, H; Wüllner, U | 1 |
| Chen, LJ; Creese, I; Dong, ZJ; Jin, GZ | 1 |
| Jin, GZ; Liu, J; Zou, LL | 1 |
| Eken, S; Gerhardt, GA; Hoffer, BJ; Hoffman, AF; van Horne, CG | 1 |
| Gassen, M; Pinchasi, B; Youdim, MB | 1 |
| Huston, JP; Schwarting, RK | 1 |
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| Bolondi, C; Cantelli-Forti, G; Hrelia, P; Morroni, F; Sita, G; Tarozzi, A; Zolezzi Moraga, JM | 1 |
| He, Q; Li, R; Liang, T; Xu, L; Zheng, N | 1 |
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| Chen, J; Chen, S; Lei, W; Li, Y; Luo, C; Ma, Y; OuYang, L; Wu, J; Zhan, M | 1 |
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| Du, GH; Du, LD; He, GR; Mu, X; Yuan, X | 1 |
| Czarnecka, A; Konieczny, J; Lenda, T; Lorenc-Koci, E | 1 |
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| Alipour Heidari, M; Dargahi, T; Faraji, A; Fraidouni, N; Haghdoost-Yazdi, H; Najafipour, R; Piri, H | 1 |
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| Benítez-Valenzuela, J; Colín-González, AL; de Jesús Negrete-Ruíz, M; Martínez-Sánchez, JE; Maya-López, M; Parra-Cid, C; Rangel-López, E; Ruiz-Contreras, HA; Sánchez-Chapul, L; Santamaría, A; Villeda-Hernández, J | 1 |
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| Alam, M; Grothe, C; Jin, X; Krauss, JK; Ratzka, A; Rumpel, R; Schwabe, K; Tschirner, SK; von Wrangel, C | 1 |
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| Babayan-Tazehkand, A; Haghdoost-Yazdi, H; Rastgoo, N; Sarbazi-Golezari, A; Sarookhani, MR | 1 |
| Airavaara, M; Bäck, S; Huotarinen, A; Julku, U; Laakso, A; Männistö, PT; Penttinen, AM; Piepponen, TP; Saarma, M; Tuominen, R; Voutilainen, MH | 1 |
| Bjarkam, CR; Christensen, AB; Ettrup, KS; Orlowski, D; Sørensen, JCH | 1 |
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| Du, CX; Liu, J; Sun, YN; Wang, HS; Wang, Y; Yao, L; Zhang, GJ; Zhang, L | 1 |
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| Abd-Elrahman, KS; Bureau, SC; Derksen, A; Dwyer, Z; Farmer, K; Ferguson, SSG; Fortin, T; Hayley, S; Prowse, NA; Rowe, EM; Rudyk, CA; Thompson, AM | 1 |
| da Costa, RO; de Araújo, DP; de Barros Viana, GS; de Lucena, JD; Gadelha-Filho, CVJ; Lima, FAV; Neves, KRT | 1 |
| Bulgakova, NV; Gonchar, OO; Kopyak, BS; Kostyukov, AI; Mankivska, OP; Maznychenko, AV; Mishchenko, IV; Prylutskyy, YI; Ritter, U; Sokolowska Vereshchaka, IV; Tomiak, T | 1 |
| Shao, M; Wang, R | 1 |
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| Fu, X; Liu, J; Lu, XJ; Sun, Y; Xia, CL; Zhan, Y; Zhang, Y; Zhao, L | 1 |
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| Alamilla, J; Álvarez-Cervera, FJ; Aranda-González, II; Calderón-Sauri, A; Cuevas-Carbonell, SG; Dawn-Ojeda, A; García-López, D; García-Miss, MDR; Góngora-Alfaro, JL; Granados-Patrón, D; Mut-Martín, M; Olivera-Castillo, L; Parra-Paz, VG; Salgado, H; Vásquez-Celaya, L | 1 |
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| Goudarzvand, M; Hajikhani, R; Jafari, F; Qorbani, M; Solati, J | 1 |
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5 review(s) available for apomorphine and oxidopamine
| Article | Year |
|---|---|
Intramembrane interactions between neurotensin receptors and dopamine D2 receptors as a major mechanism for the neuroleptic-like action of neurotensin.
Topics: Animals; Antipsychotic Agents; Apomorphine; Basal Ganglia; Behavior, Animal; Brain; Cell Membrane; Dopamine; Dopamine Agents; Enkephalins; gamma-Aminobutyric Acid; GTP-Binding Proteins; Neurons; Neurotensin; Oxidopamine; Rats; Receptors, Dopamine D2; Receptors, Neurotensin; Receptors, Neurotransmitter | 1992 |
Chemical and physiological aspects of the actions of lithium and antidepressant drugs.
Topics: Animals; Antidepressive Agents; Apomorphine; Blood Pressure; Brain Chemistry; Diet; Endorphins; Haloperidol; Humans; Hydroxydopamines; Hypertension; Lithium; Motor Activity; Oxidopamine; Rats; Receptors, Dopamine; Stereotyped Behavior | 1983 |
Classification of dopamine receptors.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Butyrophenones; Dopamine; Hydroxydopamines; In Vitro Techniques; Membranes, Artificial; Oxidopamine; Receptors, Dopamine; Spiperone | 1983 |
Potent neuroprotective and antioxidant activity of apomorphine in MPTP and 6-hydroxydopamine induced neurotoxicity.
Topics: Animals; Antioxidants; Apomorphine; Free Radical Scavengers; Iron Chelating Agents; Mice; MPTP Poisoning; Neuroprotective Agents; Neurotoxins; Oxidopamine; Rats | 1999 |
Peter H. Kelly, Paul W. Seviour and Susan D. Iversen (1975) "Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum" [Brain Res. 94 (3) 507-522].
Topics: Amphetamine; Animals; Apomorphine; Corpus Striatum; Dopamine; Dopamine Agents; Locomotion; Nucleus Accumbens; Oxidopamine; Rats; Stereotyped Behavior | 2016 |
697 other study(ies) available for apomorphine and oxidopamine
| Article | Year |
|---|---|
NBQX (6-nitro-sulfamoyl-benzo-quinoxaline-dione) and CPP (3-carboxy-piperazin-propyl phosphonic acid) potentiate dopamine agonist induced rotations in substantia nigra lesioned rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amphetamine; Animals; Apomorphine; Dopamine Agents; Drug Synergism; Ibotenic Acid; Lisuride; Male; Neurons; Oxidopamine; Parkinson Disease, Secondary; Piperazines; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Stereotyped Behavior; Substantia Nigra; Sympathectomy, Chemical | 1992 |
Activation of the zinc finger encoding gene krox-20 in adult rat brain: comparison with zif268.
Topics: Animals; Apomorphine; Benzazepines; Brain; DNA-Binding Proteins; Early Growth Response Protein 1; Early Growth Response Protein 2; Electroshock; Haloperidol; Immediate-Early Proteins; Male; Morphine; Naltrexone; Nucleic Acid Hybridization; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reserpine; Seizures; Substance Withdrawal Syndrome; Transcription Factors; Transcription, Genetic; Zinc Fingers | 1992 |
Apomorphine induction of AP-1 DNA binding in the rat striatum after dopamine depletion.
Topics: Animals; Apomorphine; Base Sequence; Corpus Striatum; DNA; Dopamine; Genes, fos; Male; Molecular Sequence Data; Nuclear Proteins; Oxidopamine; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Sympathectomy, Chemical; Transcription Factors | 1992 |
Dopaminergic transplants normalize amphetamine- and apomorphine-induced Fos expression in the 6-hydroxydopamine-lesioned striatum.
Topics: Animals; Apomorphine; Brain; Brain Tissue Transplantation; Corpus Striatum; Dextroamphetamine; Female; Fetal Tissue Transplantation; Gene Expression; Genes, fos; Immunohistochemistry; Mesencephalon; Nerve Fibers; Organ Specificity; Oxidopamine; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred Strains; Reference Values; Tyrosine 3-Monooxygenase | 1992 |
Tetrahydrobiopterin-dependent functional recovery in 6-hydroxydopamine-treated rats by intracerebral grafting of fibroblasts transfected with tyrosine hydroxylase cDNA.
Topics: Animals; Apomorphine; Behavior, Animal; Biopterins; Brain; Cell Line, Transformed; DNA; Female; Fibroblasts; Levodopa; Oxidopamine; Rats; Rats, Wistar; Stereotyped Behavior; Transfection; Tyrosine 3-Monooxygenase | 1992 |
Transplantation of embryonic mesencephalic and medullary raphe neurons to the neostriatum of rats with unilateral 6-hydroxydopamine lesions.
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Brain Tissue Transplantation; Corpus Striatum; Fetal Tissue Transplantation; Immunohistochemistry; Medulla Oblongata; Mesencephalon; Neurons; Oxidopamine; Raphe Nuclei; Rats; Rats, Wistar; Serotonin; Stereotyped Behavior; Tyrosine 3-Monooxygenase | 1992 |
Dual actions of (-)-stepholidine on dopamine receptor subtypes after substantia nigra lesion.
Topics: Animals; Apomorphine; Berberine; Dopamine Antagonists; Male; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Stereoisomerism; Stereotyped Behavior; Substantia Nigra; Tetrahydronaphthalenes; Thiophenes | 1992 |
Autoradiographic study of striatal D1 and D2 dopamine receptors in 6-OHDA-lesioned rats receiving foetal ventral mesencephalic grafts and chronic treatment with L-dopa and carbidopa.
Topics: Animals; Apomorphine; Autoradiography; Brain Tissue Transplantation; Carbidopa; Corpus Striatum; Dextroamphetamine; Female; Fetal Tissue Transplantation; In Vitro Techniques; Levodopa; Mesencephalon; Oxidopamine; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Time Factors | 1992 |
Basic fibroblast growth factor ameliorates rotational behavior of substantia nigral-transplanted rats with lesions of the dopaminergic nigrostriatal neurons.
Topics: Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Female; Fibroblast Growth Factor 2; Gliosis; Immunohistochemistry; Neural Pathways; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Inbred Strains; Rotation; Substantia Nigra | 1992 |
Differential effects of mesocortical, mesolimbic, and mesostriatal dopamine depletion on spontaneous, conditioned, and drug-induced locomotor activity.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Caudate Nucleus; Conditioning, Operant; Corpus Striatum; Dextroamphetamine; Dopamine; Limbic System; Male; Motor Activity; Oxidopamine; Prefrontal Cortex; Putamen; Rats; Sympathectomy, Chemical | 1992 |
Ontogeny of apomorphine-induced stereotypy and its D1 and D2 receptor mediation in rats depleted of dopamine as neonates.
Topics: Aging; Animals; Apomorphine; Dose-Response Relationship, Drug; Female; Male; Motor Activity; Oxidopamine; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Stereotyped Behavior | 1992 |
Regulatory behaviour, exploration and locomotion following NMDA or 6-OHDA lesions in the rat nucleus accumbens.
Topics: Animals; Apomorphine; Body Weight; Brain Mapping; Dextroamphetamine; Dopamine; Dose-Response Relationship, Drug; Drinking Behavior; Exploratory Behavior; Feeding Behavior; Limbic System; Locomotion; Male; Motor Activity; N-Methylaspartate; Neural Pathways; Nucleus Accumbens; Oxidopamine; Rats; Receptors, Dopamine; Stereotyped Behavior; Substantia Nigra; Tegmentum Mesencephali | 1992 |
Opponent-process theory and drug conditioning: an assessment for conditioned stimulant-induced movement.
Topics: Animals; Apomorphine; Arousal; Association Learning; Conditioning, Classical; Corpus Striatum; Dominance, Cerebral; Dopamine; Dose-Response Relationship, Drug; Functional Laterality; Haloperidol; Homeostasis; Locomotion; Male; Motor Activity; Neural Pathways; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Stereotyped Behavior; Substantia Nigra | 1992 |
The intrastriatal 6-hydroxydopamine model of hemiparkinsonism: quantitative receptor autoradiographic evidence of correlation between circling behavior and presynaptic as well as postsynaptic nigrostriatal markers in the rat.
Topics: Amphetamine; Animals; Apomorphine; Autoradiography; Biomarkers; Corpus Striatum; Immunohistochemistry; Injections; Male; Mazindol; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Substantia Nigra; Synapses | 1992 |
Synergism of NBQX with dopamine agonists in the 6-OHDA rat model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apomorphine; Drug Synergism; Lisuride; Male; Motor Activity; Oxidopamine; Parkinson Disease, Secondary; Quinoxalines; Rats; Rats, Wistar; Stereotaxic Techniques; Substantia Nigra | 1992 |
Fos expression in intrastriatal striatal grafts: regulation by host dopaminergic afferents.
Topics: Afferent Pathways; Animals; Apomorphine; Brain Tissue Transplantation; Corpus Striatum; Dextroamphetamine; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Female; Fetal Tissue Transplantation; Genes, fos; Ibotenic Acid; Immunohistochemistry; Nerve Tissue Proteins; Oxidopamine; Phosphoproteins; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred Strains; Substantia Nigra | 1992 |
Messenger RNAs encoding glutamate-decarboxylases are differentially affected by nigrostriatal lesions in subpopulations of striatal neurons.
Topics: Animals; Apomorphine; Autoradiography; Corpus Striatum; Desipramine; Glutamate Decarboxylase; Isoenzymes; Male; Molecular Weight; Neurons; Oxidopamine; Rats; Rats, Inbred Strains; Reference Values; RNA Probes; RNA, Messenger; Substantia Nigra; Sulfur Radioisotopes | 1992 |
Repeated D1 dopamine receptor agonist administration prevents the development of both D1 and D2 striatal receptor supersensitivity following denervation.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Cerebral Ventricles; Corpus Striatum; Denervation; Desipramine; Dopamine; Electrophysiology; Ergolines; Injections, Intraventricular; Iontophoresis; Male; Membrane Potentials; Motor Activity; Multivariate Analysis; Neurons; Oxidopamine; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Reference Values; Substantia Nigra | 1992 |
Induction of D2 dopamine receptor mRNA synthesis in a 6-hydroxydopamine parkinsonian rat model.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Blotting, Northern; Corpus Striatum; Dopamine; Female; Homovanillic Acid; Neurons, Efferent; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; RNA, Messenger; Spiperone; Stereotyped Behavior; Substantia Nigra | 1992 |
Motor function, graft survival and gliosis in rats with 6-OHDA lesions and foetal ventral mesencephalic grafts chronically treated with L-dopa and carbidopa.
Topics: Animals; Apomorphine; Brain Tissue Transplantation; Carbidopa; Dextroamphetamine; Female; Fetal Tissue Transplantation; Gliosis; Graft Survival; Immunohistochemistry; Levodopa; Mesencephalon; Neuroglia; Oxidopamine; Psychomotor Performance; Rats; Rats, Inbred Strains; Stereotaxic Techniques; Stereotyped Behavior; Sympathectomy, Chemical | 1992 |
Apomorphine decreases extracellular GABA in the ventral pallidum of rats with 6-OHDA lesions in the nucleus accumbens.
Topics: Animals; Apomorphine; Dialysis; Dopamine; gamma-Aminobutyric Acid; Globus Pallidus; Male; Motor Activity; Nucleus Accumbens; Oxidopamine; Rats; Rats, Inbred Strains | 1992 |
The ACTH-(4-9) analogue ORG 2766 facilitates denervation supersensitivity after a unilateral 6-OHDA lesion of the corpus striatum in rats.
Topics: Adrenocorticotropic Hormone; Animals; Apomorphine; Corpus Striatum; Denervation; Male; Motor Activity; Oxidopamine; Peptide Fragments; Rats; Rats, Inbred Strains | 1991 |
Behavioral evidence of depolarization block of mesencephalic dopamine neurons by acute haloperidol in partially 6-hydroxydopamine-lesioned rats.
Topics: Animals; Apomorphine; Brain Mapping; Corpus Striatum; Dopamine; Haloperidol; Male; Medial Forebrain Bundle; Mesencephalon; Motivation; Neural Pathways; Neurons; Norepinephrine; Nucleus Accumbens; Oxidopamine; Rats; Receptors, Dopamine; Self Stimulation; Serotonin; Synaptic Transmission | 1991 |
Alpha 2-adrenoceptors are not involved in the regulation of striatal glutamate release: comparison to dopaminergic inhibition.
Topics: 4-Butyrolactone; Animals; Apomorphine; Berberine; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Drug Interactions; Glutamates; Glutamic Acid; Haloperidol; Hydrazines; Hydroxydopamines; Male; Oxidopamine; Potassium Chloride; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Secretory Rate; Synaptic Transmission; Yohimbine | 1991 |
Chronic eticlopride and dopamine denervation induce equal nonadditive increases in striatal D2 receptor density: autoradiographic evidence against the dual mechanism hypothesis.
Topics: Analysis of Variance; Animals; Apomorphine; Autoradiography; Corpus Striatum; Denervation; Dopamine; Dopamine Agents; Ergolines; Hydroxydopamines; Male; Mazindol; Nucleus Accumbens; Oxidopamine; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Salicylamides; Tritium | 1991 |
Partial lesion of the substantia nigra: relation between extent of lesion and rotational behavior.
Topics: Amphetamine; Animals; Apomorphine; Axons; Denervation; Disease Models, Animal; Female; Motor Activity; Neurons; Oxidopamine; Parkinson Disease; Rats; Rats, Inbred Strains; Rotation; Substantia Nigra; Tyrosine 3-Monooxygenase | 1991 |
Lesioning of the striatum reverses motor asymmetry in the 6-hydroxydopamine rodent model of parkinsonism.
Topics: Adrenal Medulla; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Graft Survival; Immunohistochemistry; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Inbred Strains; Rotation; Stereotaxic Techniques; Stereotyped Behavior; Substantia Nigra; Sympathectomy, Chemical; Tyrosine 3-Monooxygenase | 1991 |
Alpha-methyltyrosine blocks the expression of rotation classically conditioned with apomorphine.
Topics: alpha-Methyltyrosine; Animals; Apomorphine; Behavior, Animal; Conditioning, Classical; Male; Methyltyrosines; Oxidopamine; Rats; Rats, Inbred Strains; Substantia Nigra; Sympathectomy, Chemical; Tyrosine 3-Monooxygenase | 1991 |
Intrastriatal dopaminergic agents, muscarinic stimulation, and GABA antagonism compared for rotation responses in rats.
Topics: Amphetamine; Animals; Apomorphine; Carbachol; Corpus Striatum; Dopamine; Dopamine Agents; GABA Antagonists; Haloperidol; Male; Microinjections; Oxidopamine; Parasympathomimetics; Rats; Rats, Inbred Strains; Rotation; Stereotaxic Techniques; Stereotyped Behavior; Substantia Nigra | 1991 |
Effects of locally applied D1 and D2 agonists on striatal neurons with 6-OHDA and pertussis toxin lesions.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Caudate Nucleus; Corpus Striatum; Dopamine Agents; Female; Nervous System Diseases; Neurons; Oxidopamine; Pertussis Toxin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Stereotaxic Techniques; Sympathectomy, Chemical; Tetrahydronaphthalenes; Thiophenes; Up-Regulation; Virulence Factors, Bordetella | 1991 |
Baseline and apomorphine-induced extracellular levels of nigral substance P are increased in an animal model of Parkinson's disease.
Topics: Animals; Apomorphine; Dialysis; Disease Models, Animal; Dopamine; Ganglia, Sympathetic; Hydroxydopamines; Neurons; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Inbred Strains; Substance P; Substantia Nigra | 1990 |
Transplantation of microencapsulated bovine chromaffin cells reduces lesion-induced rotational asymmetry in rats.
Topics: Animals; Apomorphine; Behavior, Animal; Catecholamines; Cattle; Chromaffin System; Corpus Striatum; Drug Compounding; Male; Oxidopamine; Rats; Rats, Inbred Strains; Rotation; Stereotyped Behavior; Tissue Transplantation | 1991 |
Decrease of behavioral and biochemical denervation supersensitivity of rat striatum by nigral transplants.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamine; Animals; Apomorphine; Brain Tissue Transplantation; Corpus Striatum; Denervation; Dopamine; Ergolines; Fetal Tissue Transplantation; Homovanillic Acid; Indoles; Mesencephalon; Motor Activity; Oxidopamine; Phenanthridines; Quinpirole; Rats; Receptors, Dopamine; Substantia Nigra | 1991 |
Pavlovian conditioning between co-administered drugs: elicitation of an apomorphine-induced antiparkinsonian response by scopolamine.
Topics: Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Conditioning, Classical; Cues; Dopamine; Male; Oxidopamine; Rats; Rats, Inbred Strains; Rotation; Scopolamine; Sympathectomy, Chemical | 1991 |
Microencapsulated dopamine (DA)-induced restitution of function in 6-OHDA-denervated rat striatum in vivo: comparison between two microsphere excipients.
Topics: Animals; Apomorphine; Corpus Striatum; Denervation; Dopamine; Drug Compounding; Drug Implants; Excipients; Male; Microspheres; Motor Activity; Oxidopamine; Polyglactin 910; Rats; Rats, Inbred Strains | 1991 |
Behavioral and biochemical effects of a novel calcium antagonist, KB-2796, on the central dopaminergic system.
Topics: Animals; Apomorphine; Behavior, Animal; Biogenic Monoamines; Brain; Brain Diseases; Calcium Channel Blockers; Corpus Striatum; Dopamine; Locomotion; Male; Methamphetamine; Mice; Oxidopamine; Piperazines | 1991 |
The serotonin (5-HT)1A agonist, LY 165,163, induces contralateral rotation in unilateral substantia nigra-lesioned rats via dopamine receptors.
Topics: Alprenolol; Animals; Apomorphine; Benzazepines; Haloperidol; Male; Motor Activity; Oxidopamine; Piperazines; Raclopride; Rats; Rats, Inbred Strains; Receptors, Dopamine; Salicylamides; Serotonin Antagonists; Substantia Nigra | 1991 |
Sensitization and conditioned rotation: apomorphine, quinpirole and SKF-38393 compared.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Ergolines; Female; Motor Activity; Oxidopamine; Quinpirole; Rats; Rats, Inbred Strains; Substantia Nigra; Time Factors | 1991 |
Chronic L-dopa treatment in the unilateral 6-OHDA rat: evidence for behavioral sensitization and biochemical tolerance.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Carbidopa; Corpus Striatum; Denervation; Drug Tolerance; Functional Laterality; Homovanillic Acid; Levodopa; Male; Motor Activity; Oxidopamine; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1991 |
Melatonin modulates apomorphine-induced rotational behaviour.
Topics: Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Huntington Disease; Hydroxydopamines; Male; Melatonin; Motor Activity; Oxidopamine; Parkinson Disease, Secondary; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains | 1991 |
Cooperation between D1- and D2-dopamine receptors in the nucleus accumbens.
Topics: Animals; Apomorphine; Benzazepines; Carrier Proteins; Dopamine and cAMP-Regulated Phosphoprotein 32; Hydroxydopamines; Intracellular Signaling Peptides and Proteins; Male; Nerve Tissue Proteins; Nucleus Accumbens; Oxidopamine; Phosphoproteins; Phosphorylation; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Sulpiride | 1991 |
Positive and negative interactions in the behavioural expression of D1 and D2 receptor stimulation in a model of Parkinsonism: role of priming.
Topics: Animals; Apomorphine; Behavior, Animal; Benzazepines; Disease Models, Animal; Dopamine Antagonists; Hydroxydopamines; Male; Oxidopamine; Parkinson Disease; Raclopride; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Salicylamides; Stereotyped Behavior | 1991 |
Dopamine D1 receptor behavioral responsitivity following selective lesions of the striatal patch compartment during development.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Analysis of Variance; Animals; Animals, Newborn; Apomorphine; Autoradiography; Corpus Striatum; Haloperidol; Hydroxydopamines; Levodopa; Mazindol; Motor Activity; Neurotoxins; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Stereotyped Behavior; Tritium | 1991 |
Cocaine-induced turning behavior in rats with 6-hydroxydopamine lesions: effect of transplants of fetal substantia nigra.
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Brain Diseases; Brain Tissue Transplantation; Cocaine; Dopamine; Fetal Tissue Transplantation; Fluoxetine; Imipramine; Male; Neural Pathways; Neurotransmitter Uptake Inhibitors; Nomifensine; Oxidopamine; Piperazines; Rats; Rats, Inbred Strains; Substantia Nigra | 1991 |
Striatal A2 receptor regulates apomorphine-induced turning in rats with unilateral dopamine denervation.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Apomorphine; Brain Chemistry; Corpus Striatum; Denervation; Dopamine; Dose-Response Relationship, Drug; Hydroxydopamines; Oxidopamine; Rats; Receptors, Purinergic; Stereotyped Behavior; Substantia Nigra; Sympathectomy, Chemical; Theophylline | 1991 |
The effect of chronic L-dopa treatment on the recovery of motor function in 6-hydroxydopamine-lesioned rats receiving ventral mesencephalic grafts.
Topics: Animals; Apomorphine; Body Weight; Carbidopa; Corpus Striatum; Drinking; Female; Fetal Tissue Transplantation; Hydroxydopamines; Levodopa; Mesencephalon; Motor Activity; Nervous System; Oxidopamine; Parkinson Disease; Rats; Rotation; Stereotyped Behavior; Time Factors | 1991 |
Interaction between enkephalinergic and dopaminergic systems in stressful situations.
Topics: Animals; Apomorphine; Conditioning, Operant; Corpus Striatum; Dopamine; Enkephalin, Methionine; Enkephalins; Hydroxydopamines; Male; Mice; Mice, Inbred Strains; Motor Activity; Neurons; Oxidopamine; Pimozide; Receptors, Dopamine; Stress, Psychological | 1991 |
Correlation of functional recovery after a 6-hydroxydopamine lesion with survival of grafted fetal neurons and release of dopamine in the striatum of the rat.
Topics: Amphetamine; Animals; Apomorphine; Cell Survival; Corpus Striatum; Dialysis; Dopamine; Female; Fetal Tissue Transplantation; Histocytochemistry; Hydroxydopamines; Neurons; Neurotoxins; Oxidopamine; Rats; Rotation; Stereotyped Behavior | 1991 |
2-Bromolisuride, an ergot derivative, with dopamine antagonistic and serotonin agonistic properties.
Topics: Animals; Apomorphine; Cyproheptadine; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Hydroxydopamines; Limbic System; Lisuride; Male; Motor Activity; Oxidopamine; Rats; Rats, Inbred Strains; Serotonin; Stereotyped Behavior; Sympathectomy, Chemical | 1991 |
Functional enhancement of intrastriatal dopamine-containing grafts by the co-transplantation of sciatic nerve tissue in 6-hydroxydopamine-lesioned rats.
Topics: Animals; Apomorphine; Brain Tissue Transplantation; Corpus Striatum; Dopamine; Fetal Tissue Transplantation; Graft Survival; Hydroxydopamines; Immunohistochemistry; Male; Mesencephalon; Nerve Regeneration; Oxidopamine; Rats; Rats, Inbred F344; Sciatic Nerve; Stereotyped Behavior | 1991 |
Naloxone enhances the release of acetylcholine from cholinergic interneurons of the striatum if the dopaminergic input is impaired.
Topics: Acetylcholine; Animals; Apomorphine; Cerebral Ventricles; Corpus Striatum; Dopamine; Injections, Intraventricular; Interneurons; Male; Naloxone; Neurotoxins; Oxidopamine; Rats; Rats, Inbred Strains; Reference Values; Sulpiride | 1991 |
Possible mechanisms of action of adrenal transplants in Parkinson's disease.
Topics: Adrenal Medulla; Aging; Animals; Apomorphine; Brain Tissue Transplantation; Bucladesine; Caudate Nucleus; Cerebral Ventricles; Dominance, Cerebral; Dopamine; Fetal Tissue Transplantation; Hydroxydopamines; Male; Motor Activity; Oxidopamine; Pain; Parkinson Disease; Rats; Rats, Inbred Strains; Sensory Thresholds; Substantia Nigra; Transplantation, Heterotopic | 1990 |
Differential modulation of striatonigral dynorphin and enkephalin by dopamine receptor subtypes.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Corpus Striatum; Dynorphins; Enkephalins; Ergolines; Hydroxydopamines; Male; Oxidopamine; Quinpirole; Rats; Rats, Inbred F344; Receptors, Dopamine; Substantia Nigra | 1990 |
Expression of neuropeptide Y immunoreactivity in the rat nucleus accumbens is under the influence of the dopaminergic mesencephalic pathway.
Topics: alpha-Methyltyrosine; Animals; Apomorphine; Dopamine; Dopamine Antagonists; Female; Hydroxydopamines; Mesencephalon; Methyltyrosines; Neuropeptide Y; Nucleus Accumbens; Oxidopamine; Rats; Rats, Inbred Strains; Reference Values; Septal Nuclei; Substantia Nigra; Tyrosine 3-Monooxygenase | 1990 |
Influence of nigrostriatal dopaminergic tone on the biosynthesis of dynorphin and enkephalin in rat striatum.
Topics: Animals; Apomorphine; Corpus Striatum; Dextroamphetamine; Dopamine; Dynorphins; Enkephalins; Hydroxydopamines; Male; Oxidopamine; Rats; Rats, Inbred F344; Reference Values; RNA, Messenger; Substantia Nigra | 1990 |
Cocaine and local anesthetics: stimulant activity in rats with nigral lesions.
Topics: Aminobenzoates; Anesthetics, Local; Animals; Apomorphine; Central Nervous System Stimulants; Cocaine; Female; Hydroxydopamines; Mepivacaine; Oxidopamine; Procaine; Propanolamines; Rats; Rats, Inbred Strains; Stereotyped Behavior; Substantia Nigra; Sympathectomy, Chemical; Tetracaine | 1990 |
An assessment of the validity of densitometric measures of striatal tyrosine hydroxylase-positive fibers: relationship to apomorphine-induced rotations in 6-hydroxydopamine lesioned rats.
Topics: Animals; Apomorphine; Corpus Striatum; Densitometry; Hydroxydopamines; Immunoenzyme Techniques; Male; Nerve Fibers; Neurotoxins; Oxidopamine; Rats; Rats, Inbred Strains; Reference Values; Stereotyped Behavior; Tyrosine 3-Monooxygenase | 1990 |
Intraventricular injection of neurotensin reduces dopamine D2 agonist binding in rat forebrain and intermediate lobe of the pituitary gland. Relationship to serum hormone levels and nerve terminal coexistence.
Topics: Animals; Apomorphine; Autoradiography; Brain; Cerebral Ventricles; Colchicine; Corticosterone; Dopamine Agents; Hydroxydopamines; Injections, Intraventricular; Luteinizing Hormone; Male; Nerve Endings; Neurotensin; Organ Specificity; Oxidopamine; Pituitary Gland; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Tritium; Tyrosine 3-Monooxygenase | 1990 |
Importance of catecholamine release for the functional action of intrastriatal implants of adrenal medullary cells: pharmacological analysis and in vivo electrochemistry.
Topics: Adrenal Medulla; Amphetamine; Animals; Apomorphine; Catecholamines; Chromaffin System; Corpus Striatum; Denervation; Dopamine; Electrochemistry; Hydroxydopamines; Immunohistochemistry; Male; Motor Activity; Nicotine; Oxidopamine; Pimozide; Rats; Rats, Inbred Strains; Transplantation, Heterotopic | 1990 |
Effects of B-HT 920 on nigrostriatal and mesolimbic dopamine systems in normosensitive and supersensitive rats.
Topics: Animals; Apomorphine; Azepines; Biogenic Monoamines; Brain Chemistry; Corpus Striatum; Dopamine; Haloperidol; Hydroxydopamines; Limbic System; Male; Medial Forebrain Bundle; Motor Activity; Nucleus Accumbens; Oxidopamine; Pargyline; Rats; Stereotyped Behavior; Substantia Nigra | 1990 |
Injections of 6-hydroxydopamine in the substantia nigra of the rat brain: morphological and biochemical effects.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Brain Mapping; Caudate Nucleus; Dominance, Cerebral; Dopamine; Hydroxydopamines; Male; Motor Activity; Nerve Fibers; Neurons; Nucleus Accumbens; Oxidopamine; Phenylacetates; Putamen; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereotyped Behavior; Substantia Nigra; Tegmentum Mesencephali | 1990 |
Dopamine receptors mediate drug-induced but not Pavlovian conditioned contralateral rotation in the unilateral 6-OHDA animal model.
Topics: Animals; Apomorphine; Benzazepines; Conditioning, Classical; Haloperidol; Hydroxydopamines; Male; Neurotoxins; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereotyped Behavior; Substantia Nigra | 1990 |
Antiparkinsonian effects of caffeine depend upon pavlovian drug conditioning processes.
Topics: Animals; Apomorphine; Caffeine; Conditioning, Classical; Functional Laterality; Hydroxydopamines; Male; Motor Activity; Oxidopamine; Parkinson Disease; Rats; Rats, Inbred Strains; Rotation; Substantia Nigra | 1990 |
Effects of transplantation of cross-species substantia nigra into the lateral ventricle of rats with experimentally induced hemiparkinsonism.
Topics: Animals; Apomorphine; Cerebral Ventricles; Graft Survival; Hydroxydopamines; Motor Activity; Nerve Regeneration; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Inbred F344; Substantia Nigra; Transplantation, Heterologous | 1990 |
Electrophysiological properties of nigrothalamic neurons after 6-hydroxydopamine lesions in the rat.
Topics: Animals; Apomorphine; Corpus Striatum; Dopamine; Electric Stimulation; Electrophysiology; Hydroxydopamines; Male; Neurons; Neurotoxins; Oxidopamine; Rats; Rats, Inbred Strains; Substantia Nigra; Thalamus | 1990 |
Differential regulation of dopamine metabolism in solid fetal substantia nigra transplants and their terminals in the host striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamine; Animals; Apomorphine; Brain Tissue Transplantation; Corpus Striatum; Dopamine; Feedback; Fetal Tissue Transplantation; Homovanillic Acid; Hydroxydopamines; Male; Nerve Endings; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Substantia Nigra | 1990 |
Behavioural effects of intracerebral dopaminergic grafts after neonatal destruction of the mesencephalic dopaminergic system.
Topics: Animals; Animals, Newborn; Apomorphine; Behavior, Animal; Brain Tissue Transplantation; Corpus Striatum; Dopamine; Drinking Behavior; Fetal Tissue Transplantation; Hydroxydopamines; Male; Mesencephalon; Motor Activity; Oxidopamine; Rats; Spatial Behavior; Transplantation, Heterotopic | 1990 |
The effect of L-dopa and carbidopa on behavioural recovery produced by ventral mesencephalic grafts in rats.
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Brain Tissue Transplantation; Carbidopa; Corpus Striatum; Female; Fetal Tissue Transplantation; Hydroxydopamines; Levodopa; Mesencephalon; Motor Activity; Oxidopamine; Parkinson Disease; Rats; Rats, Inbred Strains; Stereotyped Behavior; Substantia Nigra | 1990 |
Mechanisms of action of adrenal medulla grafts: the possible role of peripheral and central dopamine systems.
Topics: Adrenal Medulla; Adrenalectomy; Amphetamine; Animals; Apomorphine; Blood-Brain Barrier; Cerebral Ventricles; Corpus Striatum; Disease Models, Animal; Dopamine; Female; Hydroxydopamines; Male; Models, Biological; Motor Activity; Oxidopamine; Parkinson Disease; Rats; Rats, Inbred Strains; Transplantation, Heterotopic | 1990 |
Phenotypic plasticity of locus coeruleus noradrenergic neurons after transplantation into the dopamine-depleted caudate in the rat.
Topics: Animals; Apomorphine; Brain Tissue Transplantation; Caudate Nucleus; Dopamine; Female; Fetal Tissue Transplantation; Graft Survival; Hydroxydopamines; Locus Coeruleus; Motor Activity; Neuronal Plasticity; Neurons; Norepinephrine; Oxidopamine; Parkinson Disease; Rats; Rats, Inbred Strains; Transplantation, Heterotopic | 1990 |
A functional assessment of embryonic dopaminergic grafts in the marmoset.
Topics: Amphetamine; Animals; Apomorphine; Brain Tissue Transplantation; Callitrichinae; Corpus Striatum; Disease Models, Animal; Dopamine; Fetal Tissue Transplantation; Functional Laterality; Hydroxydopamines; Mesencephalon; Motor Activity; Motor Skills; Oxidopamine; Parkinson Disease | 1990 |
Direct dopamine agonist-like activity conditioned to cocaine.
Topics: Animals; Apomorphine; Cocaine; Female; Hydroxydopamines; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Rotation; Stereotyped Behavior; Substantia Nigra | 1990 |
Behavioral changes in 6-hydroxydopamine-treated rotation rats after delivery of various neuromodifying agents by means of a stereotactically implanted pellet to the brain.
Topics: Animals; Apomorphine; Behavior, Animal; Bromocriptine; Corpus Striatum; Dominance, Cerebral; Drug Implants; Hydroxydopamines; Male; Motor Activity; Oxidopamine; Rats; Rats, Inbred Strains; Stereotaxic Techniques; Stereotyped Behavior; Substantia Nigra; Thyrotropin-Releasing Hormone | 1990 |
Sensitization of rotation behavior in rats with unilateral 6-hydroxydopamine or kainic acid-induced striatal lesions.
Topics: Animals; Apomorphine; Corpus Striatum; Hydroxydopamines; Kainic Acid; Male; Oxidopamine; Rats; Rats, Inbred Strains; Rotation; Stereotyped Behavior | 1990 |
Functional recovery after destruction of dopamine systems in the nucleus accumbens of rats. IV. Delay by intra-accumbal treatment with ORG 2766- or alpha-MSH antiserum.
Topics: Adrenocorticotropic Hormone; alpha-MSH; Animals; Apomorphine; Dopamine; Haloperidol; Hydroxydopamines; Immune Sera; Male; Motor Activity; Nucleus Accumbens; Oxidopamine; Peptide Fragments; Rats; Rats, Inbred Strains; Septal Nuclei | 1990 |
Stereospecific blockade of N-methyl-D-aspartate transmission by MK 801 prevents priming of SKF 38393-induced turning.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Hydroxydopamines; Male; N-Methylaspartate; Oxidopamine; Rats; Rats, Inbred Strains; Stereoisomerism; Stereotyped Behavior; Sympathectomy, Chemical; Synaptic Transmission | 1990 |
Role of opiates in striatal D-1 dopamine receptor supersensitivity induced by chronic L-dopa treatment.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Corpus Striatum; Drug Interactions; Hydroxydopamines; Levodopa; Male; Morphine; Naltrexone; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Opioid | 1990 |
Effect of 6-OHDA injected into the locus coeruleus on apomorphine-induced aggression.
Topics: Aggression; Animals; Apomorphine; Biogenic Amines; Hydroxydopamines; Hydroxyindoleacetic Acid; Injections; Locus Coeruleus; Male; Oxidopamine; Rats; Rats, Inbred Strains | 1986 |
Behavioral lateralization in rats and dopaminergic system: individual and population laterality.
Topics: Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Dopamine; Functional Laterality; Hydroxydopamines; Male; Oxidopamine; Rats; Rats, Inbred Strains; Substantia Nigra | 1989 |
Breaking points on a progressive ratio schedule reinforced by intravenous apomorphine increase daily following 6-hydroxydopamine lesions of the nucleus accumbens.
Topics: Animals; Apomorphine; Hydroxydopamines; Injections, Intravenous; Nucleus Accumbens; Oxidopamine; Rats; Rats, Inbred Strains; Reinforcement Schedule; Septal Nuclei | 1989 |
Computerized rotometer apparatus for recording circling behavior.
Topics: Animals; Apomorphine; Carbidopa; Computers; Dextroamphetamine; Hydroxydopamines; Levodopa; Male; Medial Forebrain Bundle; Oxidopamine; Psychology, Experimental; Rats; Rats, Inbred Strains; Software; Stereotyped Behavior | 1989 |
Neonatal dopamine-rich grafts and 6-OHDA lesions independently provide partial protection from the adult nigrostriatal lesion syndrome.
Topics: Animals; Apomorphine; Corpus Striatum; Dominance, Cerebral; Dopamine; Haloperidol; Hydroxydopamines; Male; Mesencephalon; Methamphetamine; Motor Activity; Motor Skills; Nerve Regeneration; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Substantia Nigra | 1989 |
An encapsulated dopamine-releasing polymer alleviates experimental parkinsonism in rats.
Topics: Acrylic Resins; Animals; Apomorphine; Brain; Corpus Striatum; Disease Models, Animal; Dopamine; Drug Implants; Hydroxydopamines; Male; Motor Activity; Oxidopamine; Parkinson Disease; Parkinson Disease, Secondary; Polyvinyls; Rats; Rats, Inbred Strains | 1989 |
Effect of dopaminergic denervation and transplant-derived reinnervation on a marker of striatal GABAergic function.
Topics: Amphetamine; Animals; Apomorphine; Corpus Striatum; Denervation; Dopamine; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hydroxydopamines; Kinetics; Male; Mesencephalon; Motor Activity; Oxidopamine; Rats; Rats, Inbred Strains | 1989 |
Norepinephrine stimulates behavioral activation in rats following depletion of nucleus accumbens dopamine.
Topics: Animals; Apomorphine; Corpus Striatum; Desipramine; Dopamine; Dose-Response Relationship, Drug; Hippocampus; Hydroxydopamines; Motor Activity; Norepinephrine; Nucleus Accumbens; Oxidopamine; Rats; Rats, Inbred Strains; Septal Nuclei | 1989 |
Rotational behaviour induced by theophylline in 6-OHDA nigrostriatal denervated rats is dependent on the supersensitivity of striatal dopaminergic receptors.
Topics: Animals; Apomorphine; Corpus Striatum; Denervation; Hydroxydopamines; Male; Motor Activity; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Rotation; Substantia Nigra; Theophylline | 1989 |
Comparison of adrenal and foetal nigral grafts on drug-induced rotation in rats with 6-OHDA lesions.
Topics: Adrenal Medulla; Animals; Apomorphine; Cell Separation; Corpus Striatum; Embryo, Mammalian; Female; Hydroxydopamines; Methamphetamine; Oxidopamine; Rats; Rats, Inbred Strains; Stereotyped Behavior; Substantia Nigra | 1989 |
Methylprednisolone treatments alter apomorphine-induced circling in the rat model of 6-hydroxydopamine-induced striatal denervation.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Corpus Striatum; Denervation; Dopamine; Hydroxydopamines; Male; Methylprednisolone; Oxidopamine; Rats; Rats, Inbred Strains; Stereotyped Behavior | 1989 |
A 6-hydroxydopamine-induced selective parkinsonian rat model.
Topics: Amphetamine; Animals; Apomorphine; Autoradiography; Disease Models, Animal; Functional Laterality; Hydroxydopamines; Limbic System; Male; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Stereotyped Behavior | 1989 |
Characteristics of the dopamine receptors involved in the anorectic effects of apomorphine in mice.
Topics: Animals; Apomorphine; Appetite Depressants; Body Temperature; Dextroamphetamine; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Eating; Haloperidol; Hydroxydopamines; Male; Mice; Oxidopamine; Receptors, Dopamine; Sympathectomy, Chemical; Synaptic Transmission | 1989 |
Biochemical properties of monoamine-rich human neuroblastoma cells.
Topics: Animals; Apomorphine; Behavior, Animal; Cell Line; Dopamine; HLA Antigens; Humans; Hydroxydopamines; Male; Neuroblastoma; Norepinephrine; Oxidopamine; Rats; Substantia Nigra; Tumor Cells, Cultured; Tyrosine 3-Monooxygenase | 1989 |
MIF-1 attenuates apomorphine stereotypies in adult rats after neonatal 6-hydroxydopamine.
Topics: Animals; Animals, Newborn; Apomorphine; Benzazepines; Corpus Striatum; Female; Hydroxydopamines; Motor Activity; MSH Release-Inhibiting Hormone; Oxidopamine; Pregnancy; Rats; Receptors, Dopamine; Stereotyped Behavior | 1989 |
Differential effects of pallidal lesions on the behavioural responses to SKF 38393, LY 171555 and apomorphine in the rat.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Behavior, Animal; Benzazepines; Dopamine Agents; Ergolines; Globus Pallidus; Hydroxydopamines; Kainic Acid; Medial Forebrain Bundle; Oxidopamine; Quinpirole; Rats | 1989 |
CCK-8 injected into the nucleus accumbens attenuates the supersensitive locomotor response to apomorphine in 6-OHDA and chronic-neuroleptic treated rats.
Topics: Animals; Antipsychotic Agents; Apomorphine; Brain Chemistry; Flupenthixol; Haloperidol; Hydroxydopamines; Injections; Male; Motor Activity; Nucleus Accumbens; Oxidopamine; Rats; Rats, Inbred Strains; Septal Nuclei; Sincalide; Sympathectomy, Chemical | 1989 |
A novel, fully automated rotometer for the study of turning behavior. Comparison of results under different experimental conditions.
Topics: Animals; Apomorphine; Bromocriptine; Dopamine Agents; Female; Hydroxydopamines; Kainic Acid; Male; Motor Activity; Oxidopamine; Rats; Rats, Inbred Strains; Stereotyped Behavior; Substantia Nigra | 1989 |
Involvement of GABAergic systems and benzodiazepine receptors in the jumping behavior induced by harmine and apomorphine in rats.
Topics: Alkaloids; Animals; Apomorphine; Brain; Diazepam; Flumazenil; Harmine; Hydroxydopamines; Male; Motor Activity; Muscimol; Oxidopamine; Pyridines; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1988 |
Differential involvement of dopamine D-1 and D-2 receptors in the circling behaviour induced by apomorphine, SK & F 38393, pergolide and LY 171555 in 6-hydroxydopamine-lesioned rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Animals; Antiparkinson Agents; Antipsychotic Agents; Apomorphine; Appetite Depressants; Benzazepines; Electric Stimulation; Ergolines; Humans; Hydroxydopamines; Male; Oxidopamine; Pergolide; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Sympathectomy, Chemical; Time Factors | 1985 |
[Neuroleptic properties of Y-516, a new iminodibenzyl derivative].
Topics: Animals; Antipsychotic Agents; Apomorphine; Benzazepines; Corpus Striatum; Dogs; Female; Hydroxydopamines; Hypothalamic Area, Lateral; Hypothermia, Induced; Male; Methamphetamine; Mice; Motor Activity; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Self Stimulation; Vomiting | 1985 |
Chemical lesions of the nucleus accumbens septi in rats: effects on muricide and apomorphine-induced aggression.
Topics: 5,7-Dihydroxytryptamine; Aggression; Animals; Apomorphine; Benzylamines; Dopamine; Hydroxydopamines; Male; Neurotransmitter Agents; Norepinephrine; Nucleus Accumbens; Oxidopamine; Rats; Rats, Inbred Strains; Septal Nuclei; Serotonin; Synaptic Transmission | 1986 |
Differential effect of repeated treatment with L-dopa on dopamine-D1 or -D2 receptors.
Topics: Adenylyl Cyclases; Animals; Antipsychotic Agents; Apomorphine; Benzazepines; Hydroxydopamines; Levodopa; Male; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1986 |
Effects of N-allylnormetazocine (SKF 10,047), phencyclidine, and other psychomotor stimulants in the rat following 6-hydroxydopamine lesion of the ventral tegmental area.
Topics: Amphetamine; Animals; Apomorphine; Caffeine; Central Nervous System Stimulants; Dopamine; Hydroxydopamines; Male; Motor Activity; Oxidopamine; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Scopolamine; Tegmentum Mesencephali | 1986 |
Modulatory effect of dopamine on high-affinity glutamate uptake in the rat striatum.
Topics: alpha-Methyltyrosine; Animals; Apomorphine; Corpus Striatum; Dopamine; Drug Synergism; Electric Stimulation; Glutamates; Glutamic Acid; Haloperidol; Hydroxydopamines; Male; Methyltyrosines; Oxidopamine; Rats; Rats, Inbred Strains; Sodium; Substantia Nigra | 1987 |
Supersensitivity of presynaptic receptors involved in the dopaminergic control of striatal high affinity glutamate uptake after 6-hydroxydopamine lesion of nigrostriatal dopaminergic neurons.
Topics: Animals; Apomorphine; Cerebral Cortex; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Electric Stimulation; Female; Glutamates; Glutamic Acid; Hydroxydopamines; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine D2; Receptors, Opioid; Substantia Nigra | 1988 |
Behavioural stimulation is induced by separate dopamine D-1 and D-2 receptor sites in reserpine-pretreated but not in normal rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Behavior, Animal; Benzazepines; Catalepsy; Ergolines; Hydroxydopamines; Ketanserin; Male; Motor Activity; Oxidopamine; Pergolide; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Reserpine; Stereotyped Behavior | 1985 |
Comparison of motor depressant effects of caerulein and N-propylnorapomorphine in mice.
Topics: 5,7-Dihydroxytryptamine; Animals; Apomorphine; Ceruletide; Depression, Chemical; Exploratory Behavior; Fenclonine; Haloperidol; Hydroxydopamines; Male; Mice; Motor Activity; Nerve Endings; Oxidopamine; Receptors, Dopamine; Receptors, Serotonin; Sincalide; Spiperone | 1986 |
[The influence of central monoaminergic systems on the anticonvulsive action of propranolol].
Topics: 5-Hydroxytryptophan; Animals; Anticonvulsants; Apomorphine; Biogenic Amines; Desipramine; Dose-Response Relationship, Drug; Electroshock; Fenclonine; Hydroxydopamines; Male; Mice; Norepinephrine; Oxidopamine; Propranolol; Serotonin | 1986 |
Dopamine receptor changes in response to prolonged treatment with L-dopa.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Benzazepines; Carbidopa; Corpus Striatum; Dopamine; Hydroxydopamines; Levodopa; Male; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Spiperone; Stereotyped Behavior; Substantia Nigra; Sulpiride | 1986 |
"Selective" D-1 and D-2 receptor antagonists fail to differentially alter supersensitive locomotor behavior in the rat.
Topics: Animals; Apomorphine; Benzazepines; Hydroxydopamines; Kinetics; Male; Motor Activity; Nucleus Accumbens; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone | 1986 |
Effects of D1 and D2 dopamine receptor stimulation on the activity of substantia nigra pars reticulata neurons in 6-hydroxydopamine lesioned rats: D1/D2 coactivation induces potentiated responses.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Action Potentials; Animals; Apomorphine; Benzamides; Benzazepines; Dopamine; Dopamine Antagonists; Drug Interactions; Ergolines; Hydroxydopamines; Male; Oxidopamine; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Substantia Nigra; Time Factors | 1987 |
Topography of dopamine behaviours mediated by D1 and D2 receptors revealed by intrastriatal injection of SKF 38393, lisuride and apomorphine in rats with a unilateral 6-hydroxydopamine-induced lesion.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Behavior, Animal; Benzazepines; Brain Mapping; Corpus Striatum; Female; Hydroxydopamines; Lisuride; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2 | 1987 |
Role of the substantia nigra in the expression of dopamine D1 receptor-mediated and D2 receptor-mediated behaviours.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Benzazepines; Caudate Nucleus; Ergolines; Female; Hydroxydopamines; Injections, Subcutaneous; Kainic Acid; Microinjections; Oxidopamine; Phenethylamines; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Stereotyped Behavior; Substantia Nigra; Time Factors | 1987 |
Benzamide potentiation of behavioral apomorphine-induced effects; mechanism involved.
Topics: Animals; Apomorphine; Behavior, Animal; Benzamides; Corpus Striatum; Drug Synergism; Hydroxydopamines; Male; Mice; Motor Activity; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Reserpine; Rotation; Yohimbine | 1985 |
delta 9-Tetrahydrocannabinol elicited ipsilateral circling behavior in rats with unilateral nigral lesion.
Topics: Animals; Apomorphine; Behavior, Animal; Dopamine; Dronabinol; Haloperidol; Hydroxydopamines; Male; Methamphetamine; Neurons; Oxidopamine; Rats; Rats, Inbred Strains; Substantia Nigra | 1985 |
Effects of central dopamine depletion on the d-amphetamine discriminative stimulus in rats.
Topics: Animals; Apomorphine; Brain; Cocaine; Dextroamphetamine; Discrimination, Psychological; Dopamine; Hydroxydopamines; Male; Oxidopamine; Rats; Synaptic Transmission | 1986 |
The dopamine-gamma aminobutyric acid interaction in the striatum of the rat is differently regulated by dopamine D-1 and D-2 types of receptor: evidence obtained with rotational behavioural experiments.
Topics: Animals; Apomorphine; Behavior, Animal; Bicuculline; Corpus Striatum; Hydroxydopamines; Ibotenic Acid; Male; Muscimol; Nipecotic Acids; Oxidopamine; Pergolide; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, GABA-A; Rotation | 1987 |
Conditioned rotational behavior in rats with unilateral 6-hydroxydopamine lesions of the substantia nigra.
Topics: Animals; Apomorphine; Conditioning, Classical; Dextroamphetamine; Hydroxydopamines; Male; Motor Activity; Oxidopamine; Rats; Rats, Inbred Strains; Rotation; Substantia Nigra | 1986 |
Investigation of the failure of parenterally administered haloperidol to antagonize dopamine released from micropipettes in the caudate.
Topics: Amphetamine; Animals; Apomorphine; Caudate Nucleus; Dopamine Antagonists; Dose-Response Relationship, Drug; Haloperidol; Hydroxydopamines; Infusions, Parenteral; Male; Oxidopamine; Phencyclidine; Rats; Rats, Inbred Strains; Time Factors | 1986 |
A comparative study of the locomotor activity effects of apomorphine and the "atypical dopamine agonists" (piribedil and S3608).
Topics: Animals; Apomorphine; Dopamine; Dose-Response Relationship, Drug; Hydroxydopamines; Kinetics; Male; Motor Activity; Nucleus Accumbens; Oxidopamine; Pimozide; Piperazines; Piribedil; Rats; Reserpine; Sulpiride; Synaptosomes | 1986 |
Differential effects of apomorphine on spinal reflex activity following 6-hydroxydopamine or long-term haloperidol pretreatment.
Topics: Animals; Apomorphine; Dopamine; Haloperidol; Hydroxydopamines; Male; Nociceptors; Norepinephrine; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reflex; Spinal Cord | 1986 |
Tremor at rest episodes in unilaterally 6-OHDA-induced substantia nigra lesioned rats: EEG-EMG and behavior.
Topics: Animals; Apomorphine; Behavior, Animal; Electroencephalography; Electromyography; Hydroxydopamines; Male; Oxidopamine; Rats; Rats, Inbred Strains; Substantia Nigra; Tremor | 1986 |
Reversal of supersensitive apomorphine-induced rotational behavior in mice by continuous exposure to apomorphine.
Topics: Animals; Apomorphine; Behavior, Animal; Dopamine; Drug Tolerance; Hydroxydopamines; Male; Mice; Oxidopamine; Posture; Rotation | 1986 |
A conditioned anti-parkinsonian drug effect in the hemi-parkinsonian rat.
Topics: Animals; Apomorphine; Conditioning, Classical; Corpus Striatum; Dopamine; Hydroxydopamines; Male; Oxidopamine; Parkinson Disease; Parkinson Disease, Secondary; Rats; Rats, Inbred Strains | 1986 |
Functional compensation by transplantation of cell suspensions of embryonic mesencephalon into the striatum of rats with 6-hydroxydopamine lesions.
Topics: Animals; Apomorphine; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Female; Hydrazines; Hydroxydopamines; Mesencephalon; Oxidopamine; Rats; Rats, Inbred Strains; Spiperone | 1986 |
Chronic treatment with bromocriptine induces behavioral supersensitivity in rats.
Topics: Animals; Apomorphine; Bromocriptine; Dopamine Antagonists; Humans; Hydroxydopamines; Male; Oxidopamine; Parkinson Disease; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereotyped Behavior | 1986 |
Microinjection of dopamine agonists into nucleus raphe magnus affects nociception in rats.
Topics: 5,6-Dihydroxytryptamine; Animals; Apomorphine; Cerebral Ventricles; Dopamine; Hydroxydopamines; Male; Microinjections; Nociceptors; Oxidopamine; Periaqueductal Gray; Phenylalanine; Raphe Nuclei; Rats | 1986 |
Apomorphine response plasticity in lesioned rats: supersensitivity dependency and lack of drug- or non-drug-associated environmental cuing.
Topics: Animals; Apomorphine; Contact Lenses; Corpus Striatum; Cues; Dopamine; Female; Hydroxydopamines; Oxidopamine; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence; Stereotyped Behavior; Sympathectomy, Chemical | 1986 |
Dopamine-like activities of an aminopyridazine derivative, CM 30366: a behavioural study.
Topics: Animals; Apomorphine; Behavior, Animal; Dopamine; Female; Haloperidol; Hydroxydopamines; Male; Mice; Motor Activity; Oxidopamine; Pyridazines; Rats; Rats, Inbred Strains; Stereotyped Behavior | 1986 |
The head-eye-body turning behavior induced by electrical or cholinergic stimulation of the pulvinar-lateralis posterior nucleus complex is not dependent on the catecholaminergic system.
Topics: Animals; Apomorphine; Carbachol; Catecholamines; Cats; Electric Stimulation; Female; Hydroxydopamines; Infusions, Parenteral; Male; Microinjections; Oxidopamine; Posture; Rotation; Stereotyped Behavior; Thalamic Nuclei | 1986 |
Ethanol induces rotational behavior in 6-hydroxydopamine lesioned mice.
Topics: Amphetamine; Animals; Apomorphine; Ethanol; Hydroxydopamines; Male; Mice; Oxidopamine; Receptors, Dopamine; Stereotyped Behavior | 1987 |
Suppressive effects of intraventricular injected dopamine and nomifensine on muricide induced by thiamine deficiency.
Topics: Aggression; Animals; Apomorphine; Dopamine; Hydroxydopamines; Injections, Intraventricular; Levodopa; Male; Mice; Nomifensine; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Thiamine Deficiency | 1987 |
Locomotor activity in relation to dopamine and noradrenaline in the nucleus accumbens, septal and frontal areas: a 6-hydroxydopamine study.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Circadian Rhythm; Dopamine; Frontal Lobe; Hydroxydopamines; Male; Motor Activity; Norepinephrine; Nucleus Accumbens; Oxidopamine; Rats; Rats, Inbred Strains; Septal Nuclei | 1986 |
Circling behavior in normoxic or hypoxic rats with unilateral 6-OHDA nigrostriatal lesion. Part 1. Effects of apomorphine and L-dopa.
Topics: Animals; Apomorphine; Corpus Striatum; Hydroxydopamines; Hypoxia; Levodopa; Male; Oxidopamine; Rats; Rats, Inbred Strains; Stereotyped Behavior; Substantia Nigra | 1987 |
Undrugged rotational response in nigro-striatal system-lesioned rats is related to the previous early response to apomorphine when repeatedly administered.
Topics: Animals; Apomorphine; Corpus Striatum; Drug Administration Schedule; Hydroxydopamines; Male; Motor Activity; Oxidopamine; Rats; Rats, Inbred Strains; Rotation; Substantia Nigra; Time Factors | 1987 |
Nucleus accumbens opiate-dopamine interactions and locomotor activation in the rat: evidence for a pre-synaptic locus.
Topics: Amphetamine; Animals; Apomorphine; Dopamine; Hydroxydopamines; Male; Motor Activity; Naloxone; Nucleus Accumbens; Oxidopamine; Rats; Rats, Inbred Strains; Septal Nuclei; Synapses | 1987 |
Dopamine-rich grafts ameliorate whole body motor asymmetry and sensory neglect but not independent limb use in rats with 6-hydroxydopamine lesions.
Topics: Animals; Apomorphine; Corpus Striatum; Dopamine; Female; Forelimb; Functional Laterality; Hydroxydopamines; Mesencephalon; Methamphetamine; Motor Skills; Oxidopamine; Rats; Rats, Inbred Strains; Stereotyped Behavior; Substantia Nigra | 1987 |
[Interaction of opioid peptides and the dopaminergic system in the myenteric plexus of the guniea pig ileum].
Topics: Animals; Apomorphine; Bromocriptine; Drug Interactions; Endorphins; Guinea Pigs; Haloperidol; Hydroxydopamines; Ileum; In Vitro Techniques; Myenteric Plexus; Naloxone; Oxidopamine; Receptors, Dopamine | 1987 |
Circling behaviour in rats with unilateral lesions of the nigrostriatum induced by 6-hydroxydopamine: changes induced by oral administration of cytidine-5'-diphosphocholine.
Topics: Administration, Oral; Amphetamine; Animals; Apomorphine; Behavior, Animal; Choline; Corpus Striatum; Cytidine Diphosphate Choline; Hydroxydopamines; Levodopa; Male; Oxidopamine; Rats; Rats, Inbred Strains; Substantia Nigra | 1987 |
[Functional improvement produced by transplantation of fetal neuronal cell suspensions in the rat striatum with 6-hydroxydopamine lesions].
Topics: Animals; Apomorphine; Catecholamines; Corpus Striatum; Dopamine; Female; Hydroxydopamines; Methamphetamine; Motor Activity; Neurons; Oxidopamine; Rats; Rats, Inbred Strains; Rotation | 1987 |
Comparison of the effects of fluphenazine-N-mustard on dopamine binding sites and on behavior induced by apomorphine in supersensitive mice.
Topics: Animals; Apomorphine; Binding, Competitive; Fluphenazine; Hydroxydopamines; Male; Mice; Oxidopamine; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1987 |
Apomorphine-induced yawning in rats is abolished by bilateral 6-hydroxydopamine lesions of the substantia nigra.
Topics: Animals; Apomorphine; Dopamine; Dose-Response Relationship, Drug; Grooming; Hydroxydopamines; Male; Mastication; Oxidopamine; Rats; Rats, Inbred Strains; Substantia Nigra; Yawning | 1987 |
Dopamine neurons grafted unilaterally to the nucleus accumbens affect drug-induced circling and locomotion.
Topics: Amphetamines; Animals; Apomorphine; Corpus Striatum; Dopamine; Female; Functional Laterality; Histocytochemistry; Hydroxydopamines; Mesencephalon; Motor Activity; Nucleus Accumbens; Oxidopamine; Rats; Rats, Inbred Strains; Septal Nuclei; Stereotyped Behavior | 1987 |
Ganglioside interactions with the dopaminergic system of rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Corpus Striatum; Dopamine; Gangliosides; Haloperidol; Hydroxydopamines; Injections; Injections, Intraventricular; Male; Motor Activity; Oxidopamine; Rats; Rats, Inbred F344; Substantia Nigra | 1988 |
Caffeine produces contralateral rotation in rats with unilateral dopamine denervation: comparisons with apomorphine-induced responses.
Topics: Animals; Apomorphine; Caffeine; Corpus Striatum; Denervation; Dopamine; Dose-Response Relationship, Drug; Hydroxydopamines; Injections, Intraventricular; Kainic Acid; Male; Oxidopamine; Rats; Rats, Inbred Strains; Rotation; Stereotyped Behavior; Substantia Nigra | 1988 |
Conditioning of the early behavioral response to apomorphine in the rotational model of Parkinson's disease.
Topics: Animals; Apomorphine; Conditioning, Psychological; Disease Models, Animal; Hydroxydopamines; Male; Motor Activity; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Inbred Strains | 1988 |
Prolactin-induced yawning behavior requires an intact nigro-striatal dopamine system.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Corpus Striatum; Dopamine; Hydroxydopamines; Male; Oxidopamine; Physostigmine; Prolactin; Rats; Substantia Nigra; Sympathectomy, Chemical; Yawning | 1988 |
Application of the unilateral 6-hydroxydopamine rat model of rotational behavior to the study of conditioned drug effects.
Topics: Animals; Apomorphine; Conditioning, Psychological; Hydroxydopamines; Male; Models, Neurological; Motor Activity; Oxidopamine; Rats; Rats, Inbred Strains; Rotation; Stereotyped Behavior; Substantia Nigra | 1988 |
Differences in the behavioral profile of circling under amphetamine and apomorphine in rats with unilateral lesions of the substantia nigra.
Topics: Amphetamines; Animals; Apomorphine; Dopamine; Functional Laterality; Hydroxydopamines; Male; Oxidopamine; Rats; Rats, Inbred Strains; Stereotyped Behavior; Substantia Nigra | 1988 |
Regulation of male rat copulatory behavior by preoptic incertohypothalamic dopamine neurons.
Topics: 3,4-Dihydroxyphenylacetic Acid; alpha-Methyltyrosine; Animals; Apomorphine; Brain; Copulation; Dopamine; Dose-Response Relationship, Drug; Hydroxydopamines; Male; Methyltyrosines; Oxidopamine; Preoptic Area; Rats; Sexual Behavior, Animal | 1988 |
7-[3-(4-[2,3-Dimethylphenyl]piperazinyl)propoxy]-2(1H)-quinolinone (OPC-4392), a presynaptic dopamine autoreceptor agonist and postsynaptic D2 receptor antagonist.
Topics: Animals; Apomorphine; Brain; Corpus Striatum; Diencephalon; Dihydroxyphenylalanine; Frontal Lobe; Hydroxydopamines; Kainic Acid; Kinetics; Male; Mice; Mice, Inbred ICR; Motor Activity; Oxidopamine; Piperazines; Piperidines; Quinolines; Quinolones; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereotyped Behavior; Telencephalon | 1988 |
Apomorphine induces latent rotation in lesioned rats, amphetamine does not.
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Hydroxydopamines; Male; Motor Activity; Oxidopamine; Rats; Rats, Inbred Strains; Substantia Nigra | 1988 |
In vivo dopamine (DA) receptor binding and behavioural effects of the putative DA autoreceptor antagonists (+)-AJ 76 and (+)-UH 232 in rats with a unilateral nigral 6-OH-DA lesion.
Topics: 3,4-Dihydroxyphenylacetic Acid; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Apomorphine; Behavior, Animal; Functional Laterality; Hydroxydopamines; Male; Naphthalenes; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Substantia Nigra; Tetrahydronaphthalenes | 1988 |
Two kinds of nigrostriatal asymmetry: relationship to dopaminergic drug sensitivity and 6-hydroxydopamine lesion effects in Long-Evans rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamines; Animals; Apomorphine; Corpus Striatum; Dopamine; Female; Functional Laterality; Homovanillic Acid; Hydroxydopamines; Male; Oxidopamine; Pergolide; Rats; Species Specificity; Substantia Nigra | 1988 |
Nucleus basalis prosencephali, a substrate of apomorphine-induced pecking in pigeons.
Topics: Animals; Apomorphine; Basal Ganglia; Columbidae; Dopamine; Feeding Behavior; Hydroxydopamines; Oxidopamine | 1988 |
Comparison between apomorphine and amphetamine-induced rotational behaviour in rats with a unilateral nigrostriatal pathway lesion.
Topics: Amphetamine; Animals; Apomorphine; Brain; Hydroxydopamines; Male; Motor Activity; Oxidopamine; Rats; Rats, Inbred Strains; Stereotyped Behavior | 1988 |
The role of mesolimbic dopamine in conditioned locomotion produced by amphetamine.
Topics: Animals; Apomorphine; Arousal; Conditioning, Classical; Dextroamphetamine; Dopamine; Hydroxydopamines; Limbic System; Male; Mesencephalon; Motor Activity; Norepinephrine; Nucleus Accumbens; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Synapses | 1988 |
Non-chromaffin tissue plus nerve growth factor reduces experimental parkinsonism in aged rats.
Topics: Adrenal Medulla; Age Factors; Animals; Apomorphine; Hydroxydopamines; Injections, Intraventricular; Male; Nerve Growth Factors; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Inbred Strains; Stereotyped Behavior; Substantia Nigra; Time Factors | 1988 |
Pharmacological characterization of dopaminergic influence on expression of neuropeptide Y immunoreactivity by rat striatal neurons.
Topics: alpha-Methyltyrosine; Animals; Apomorphine; Benzazepines; Cell Count; Corpus Striatum; Dopamine; Female; Haloperidol; Hydroxydopamines; Immunohistochemistry; Methyltyrosines; Neuropeptide Y; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Substantia Nigra | 1988 |
Implantable microencapsulated dopamine (DA): a new approach for slow-release DA delivery into brain tissue.
Topics: Animals; Apomorphine; Capsules; Corpus Striatum; Delayed-Action Preparations; Dopamine; Drug Implants; Hydroxydopamines; Male; Medial Forebrain Bundle; Oxidopamine; Rats; Rats, Inbred Strains; Stereotyped Behavior | 1988 |
The response of apomorphine administered into the accumbens in rats with bilateral lesions of the nucleus accumbens, induced with 6-hydroxydopamine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Dopamine; Homovanillic Acid; Hydroxydopamines; Male; Motor Activity; Nucleus Accumbens; Oxidopamine; Rats; Rats, Inbred Strains; Septal Nuclei | 1988 |
Heterogeneous rotational responsiveness in 6-hydroxydopamine-denervated rats: pharmacological and neurochemical characterization.
Topics: Animals; Apomorphine; Benzopyrans; Brain Chemistry; Corpus Striatum; Dopamine; Ergolines; Hydroxydopamines; Male; Oxidopamine; Piperidines; Quinpirole; Rats; Rats, Inbred Strains; Rotation; Stereotyped Behavior; Sympathectomy, Chemical | 1988 |
Anatomical analysis of the involvement of mesolimbocortical dopamine in the locomotor stimulant actions of d-amphetamine and apomorphine.
Topics: Animals; Apomorphine; Biogenic Amines; Cerebral Cortex; Dextroamphetamine; Hydroxydopamines; Limbic System; Male; Motor Activity; Nucleus Accumbens; Olfactory Bulb; Oxidopamine; Rats; Scopolamine; Stereotyped Behavior | 1988 |
Functional classification of different dopamine receptors.
Topics: Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Brain; Dominance, Cerebral; Dopamine; Ergolines; Flupenthixol; gamma-Aminobutyric Acid; Hydroxydopamines; Kainic Acid; Oxidopamine; Pergolide; Picrotoxin; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Sulpiride; Synapses | 1985 |
Central dopaminergic activity influences rats ability to exercise.
Topics: Animals; Apomorphine; Clonidine; Dopamine; Hydroxydopamines; Injections, Intraventricular; Male; Oxidopamine; Physical Exertion; Rats; Rats, Inbred Strains; Time Factors | 1985 |
Comparative effects of infusions of 6-hydroxydopamine into nucleus accumbens and anterolateral hypothalamus induced by 6-hydroxydopamine on the response to dopamine agonists, body weight, locomotor activity and measures of exploration in the rat.
Topics: Animals; Apomorphine; Body Weight; Brain Chemistry; Dextroamphetamine; Exploratory Behavior; Humans; Hydroxydopamines; Hypothalamus, Anterior; Injections; Locomotion; Male; Nucleus Accumbens; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereotyped Behavior | 1985 |
A pre-positron emission tomography study of L-3,4-dihydroxy-[3H]phenylalanine distribution in the rat.
Topics: Animals; Apomorphine; Autoradiography; Brain; Corpus Striatum; Desipramine; Dopamine; Hydroxydopamines; Levodopa; Male; Oxidopamine; Rats; Rats, Inbred Strains; Substantia Nigra; Tissue Distribution; Tomography, Emission-Computed | 1985 |
Quantification of lesion-induced dopaminergic supersensitivity using the rotational model in the mouse.
Topics: Animals; Apomorphine; Brain Mapping; Corpus Striatum; Dopamine; Hydroxydopamines; Mice; Mice, Inbred C57BL; Motor Activity; Neural Pathways; Oxidopamine; Substantia Nigra | 1985 |
Effect of chronic apomorphine on the development of denervation supersensitivity.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Behavior, Animal; Brain Chemistry; Corpus Striatum; Denervation; Desipramine; Dopamine; Homovanillic Acid; Hydroxydopamines; Injections; Male; Medial Forebrain Bundle; Norepinephrine; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1985 |
Increased or decreased locomotor response in rats following repeated administration of apomorphine depends on dosage interval.
Topics: Animals; Apomorphine; Brain Chemistry; Humans; Hydroxydopamines; Male; Motor Activity; Oxidopamine; Rats; Rats, Inbred Strains; Rotation; Stereotaxic Techniques; Stereotyped Behavior; Substantia Nigra; Time Factors | 1985 |
Influences of catecholamines on growth hormone release in female goldfish, Carassius auratus.
Topics: alpha-Methyltyrosine; Animals; Apomorphine; Carbidopa; Catecholamines; Cyprinidae; Dopamine; Female; Goldfish; Growth Hormone; Hydroxydopamines; Levodopa; Methyltyrosines; Norepinephrine; Oxidopamine; Phentolamine; Preoptic Area | 1985 |
The effects of dopamine and dopamine agonists on the release of 3H-GABA and 3H-5HT from rat nigral slices.
Topics: Animals; Apomorphine; Dopamine; Female; gamma-Aminobutyric Acid; Hydroxydopamines; In Vitro Techniques; Oxidopamine; Potassium Chloride; Rats; Rats, Inbred Strains; Receptors, Dopamine; Serotonin; Substantia Nigra; Synaptosomes; Tritium | 1985 |
Dopamine agonist-induced locomotor activity in rats treated with 6-hydroxydopamine at differing ages: functional supersensitivity of D-1 dopamine receptors in neonatally lesioned rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Age Factors; Animals; Animals, Newborn; Apomorphine; Benzazepines; Dopamine Antagonists; Dose-Response Relationship, Drug; Ergolines; Female; Flupenthixol; Haloperidol; Hydroxydopamines; Male; Motor Activity; Oxidopamine; Pregnancy; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1985 |
Hyperactivity induced by stimulation of separate dopamine D-1 and D-2 receptors in rats with bilateral 6-OHDA lesions.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Benzamides; Benzazepines; Clopenthixol; Dopamine; Dose-Response Relationship, Drug; Ergolines; Flupenthixol; Hydroxydopamines; Hypothalamus; Male; Motor Activity; Oxidopamine; Pergolide; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1985 |
Simple method for evaluation of stimulatory effect of drugs on presynaptic dopamine receptors in mice.
Topics: Animals; Apomorphine; Haloperidol; Hydrazines; Hydroxydopamines; Levodopa; Male; Mice; Mice, Inbred Strains; Oxidopamine; Receptors, Dopamine | 1985 |
GM1 gangliosides stimulate neuronal reorganization and reduce rotational asymmetry after hemitransections of the nigro-striatal pathway.
Topics: Animals; Apomorphine; Corpus Striatum; Dextroamphetamine; G(M3) Ganglioside; Hydroxydopamines; Male; Motor Activity; Neural Pathways; Neuronal Plasticity; Oxidopamine; Rats; Rats, Inbred Strains; Substantia Nigra | 1985 |
Effects of chronic dietary lithium on behavioral indices of dopamine denervation supersensitivity in the rat.
Topics: Animals; Apomorphine; Behavior, Animal; Body Weight; Caudate Nucleus; Diet; Hydroxydopamines; Lithium; Male; Motor Activity; Nucleus Accumbens; Oxidopamine; Rats; Rats, Inbred Strains; Stereotyped Behavior; Sympathectomy, Chemical | 1985 |
Role of dopaminergic system(s) in mediation of the behavioural effects of bombesin.
Topics: Animals; Apomorphine; Behavior, Animal; Bombesin; Dextroamphetamine; Dose-Response Relationship, Drug; Fluphenazine; Hydroxydopamines; Injections, Intraventricular; Male; Motor Activity; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1985 |
Modification of electroretinograms in dopamine-depleted retinas.
Topics: Animals; Apomorphine; Dopamine; Electroretinography; Feedback; Hydroxydopamines; Oxidopamine; Rana pipiens; Retina | 1985 |
Bilateral lesions of the striatum induced with 6-hydroxydopamine abolish apomorphine-induced yawning in rats.
Topics: Animals; Apomorphine; Corpus Striatum; Desipramine; Hydroxydopamines; Male; Oxidopamine; Rats; Rats, Inbred Strains; Reflex | 1985 |
Disruption of cocaine and heroin self-administration following kainic acid lesions of the nucleus accumbens.
Topics: Animals; Apomorphine; Brain Chemistry; Cocaine; Dopamine; Heroin; Hydroxydopamines; Kainic Acid; Male; Norepinephrine; Nucleus Accumbens; Oxidopamine; Rats; Rats, Inbred Strains; Reinforcement, Psychology; Self Administration; Septal Nuclei | 1985 |
Rotational behaviour elicited by intracerebral injections of apomorphine and pergolide in 6-hydroxy-dopamine-lesioned rats. I: Comparison between systemic and intrastriatal injections.
Topics: Animals; Apomorphine; Behavior, Animal; Brain; Corpus Striatum; Denervation; Ergolines; Hydroxydopamines; Injections; Male; Oxidopamine; Pergolide; Rats; Rats, Inbred Strains; Receptors, Dopamine; Rotation | 1985 |
Rotational behaviour elicited by intracerebral injections of apomorphine and pergolide in 6-hydroxy-dopamine-lesioned rats. II: The striatum of the rat is heterogeneously organized for rotational behaviour.
Topics: Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Denervation; Ergolines; Hydroxydopamines; Injections; Male; Nucleus Accumbens; Oxidopamine; Pergolide; Rats; Rats, Inbred Strains; Receptors, Dopamine; Rotation | 1985 |
Effect of forebrain commissurotomy on recovery from unilateral 6-OHDA lesions of the substantia nigra and circling induced by apomorphine.
Topics: Animals; Apomorphine; Behavior, Animal; Exploratory Behavior; Functional Laterality; Hydroxydopamines; Male; Motor Activity; Oxidopamine; Rats; Rats, Inbred Strains; Stereotaxic Techniques; Substantia Nigra | 1985 |
The effects of chronic bromocriptine treatment on behaviour and dopamine receptor binding in the rat striatum.
Topics: Animals; Apomorphine; Bromocriptine; Corpus Striatum; Hydroxydopamines; Kainic Acid; Male; Motor Activity; Muscle Denervation; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Substantia Nigra | 1985 |
Antidopaminergic effects of bisbenzyl and benzyl tetrahydroisoquinoline alkaloids.
Topics: Alkaloids; Animals; Apomorphine; Behavior, Animal; Benzylisoquinolines; Binding, Competitive; Catalepsy; Corpus Striatum; Hydroxydopamines; Isoquinolines; Male; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Rotation; Spiperone; Stereotyped Behavior; Tetrahydroisoquinolines | 1985 |
Effects of serotonergic activity in nucleus accumbens septi on drug-induced circling.
Topics: 5,7-Dihydroxytryptamine; Amphetamine; Animals; Apomorphine; Hydroxydopamines; Injections, Intraventricular; Male; Nucleus Accumbens; Oxidopamine; Rats; Rats, Inbred Strains; Septal Nuclei; Serotonin; Stereotyped Behavior | 1985 |
Implications of dopamine agonist-induced hypothermia following increased density of dopamine receptors in the mouse.
Topics: Animals; Apomorphine; Body Temperature; Desipramine; Dopamine; Haloperidol; Hydroxydopamines; Kinetics; Mice; Motor Activity; Oxidopamine; Receptors, Dopamine | 1985 |
Altered responding to cholecystokinins and dopaminergic agonists following 6-hydroxydopamine treatment in rats.
Topics: Animals; Apomorphine; Brain; Dopamine; Gastrins; Hydroxydopamines; Male; Methamphetamine; Motor Activity; Oxidopamine; Proglumide; Rats; Rats, Inbred Strains; Sincalide; Tetragastrin | 1985 |
Electrolytic lesions of the substantia innominata and lateral preoptic area attenuate the 'supersensitive' locomotor response to apomorphine resulting from denervation of the nucleus accumbens.
Topics: Animals; Apomorphine; Basal Ganglia; Brain Mapping; Dopamine; Hydroxydopamines; Motor Activity; Neural Pathways; Nucleus Accumbens; Oxidopamine; Preoptic Area; Rats; Rats, Inbred Strains; Septal Nuclei; Substantia Innominata; Synaptic Transmission | 1984 |
The effects of dopaminergic denervation on Na+-K+ ATPase activity and 3H-ouabain binding in rat corpus striatum.
Topics: Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Denervation; Dopamine; Hydroxydopamines; Male; Ouabain; Oxidopamine; Rats; Rats, Inbred F344; Sodium-Potassium-Exchanging ATPase; Substantia Nigra | 1984 |
Synthesis of 4-substituted 2H-naphth[1,2-b]-1,4-oxazines, a new class of dopamine agonists.
Topics: Animals; Apomorphine; Cattle; Cerebral Cortex; Clonidine; Dopamine; Hydroxydopamines; Indicators and Reagents; Models, Molecular; Molecular Conformation; Motor Activity; Oxazines; Oxidopamine; Rats; Receptors, Adrenergic, alpha; Receptors, Dopamine; Rotation; Structure-Activity Relationship | 1984 |
The neural substrates of apomorphine-stimulated locomotor activity following denervation of the nucleus accumbens.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Caudate Nucleus; Dopamine; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Hydroxydopamines; Male; Motor Activity; Muscimol; Neurons, Efferent; Norepinephrine; Nucleus Accumbens; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, GABA-A; Septal Nuclei | 1984 |
Apomorphine-induced inhibition of neostriatal activity is enhanced by lesions induced by 6-hydroxydopamine but not by long-term administration of amphetamine.
Topics: Action Potentials; Amphetamine; Animals; Apomorphine; Caudate Nucleus; Hydroxydopamines; Male; Neurons; Oxidopamine; Putamen; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Neurotransmitter | 1984 |
Effect of supersensitivity of pre- and postsynaptic dopamine receptors on the activity of endogenous inhibitor of cAMP dependent protein kinase in rat striatum.
Topics: Aminophylline; Animals; Apomorphine; Carrier Proteins; Corpus Striatum; Haloperidol; Hydroxydopamines; Intracellular Signaling Peptides and Proteins; Male; Oxidopamine; Protein Kinase Inhibitors; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Neurotransmitter; Reserpine | 1984 |
Assessing pharmacologically induced dopamine receptor sensitivity changes with the Ungerstedt turning model.
Topics: Amphetamine; Animals; Antipsychotic Agents; Apomorphine; Haloperidol; Hydroxydopamines; Male; Models, Biological; Oxidopamine; Rats; Receptors, Dopamine; Rotation | 1981 |
The effects of prolyl-leucyl-glycine amide on drug-induced rotation in lesioned rats.
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Dose-Response Relationship, Drug; Hydroxydopamines; Male; Motor Activity; MSH Release-Inhibiting Hormone; Oxidopamine; Rats; Rats, Inbred Strains; Rotation; Stereotaxic Techniques; Substantia Nigra | 1982 |
Does contralateral circling involve action of drugs on hyposensitive striatal dopamine receptors in the hemisphere contralateral to denervation?
Topics: Animals; Antipsychotic Agents; Apomorphine; Corpus Striatum; Humans; Hydroxydopamines; Male; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereotyped Behavior | 1983 |
Stimulation of postsynaptic DA2 receptors produces jerks in reserpine-treated rats.
Topics: Animals; Apomorphine; Azepines; Behavior, Animal; Corpus Striatum; Hydroxydopamines; Injections; Male; Nucleus Accumbens; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Reserpine | 1983 |
Different actions of TL-99 and 3-PPP in producing contraversive turning in the 6-OHDA-lesioned rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Apomorphine; Female; Hydroxydopamines; Motor Activity; Naphthalenes; Oxidopamine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Substantia Nigra; Tetrahydronaphthalenes; Yohimbine | 1983 |
Pharmacological characterization of the receptors involved in the apomorphine-induced polyphasic modifications of locomotor activity in mice.
Topics: Animals; Antipsychotic Agents; Apomorphine; Body Temperature; Drug Interactions; Hydroxydopamines; Injections, Intraventricular; Male; Mice; Motor Activity; Oxidopamine; Receptors, Dopamine | 1983 |
Pharmacological characteristics of dopamine receptors involved in the dual effect of dopamine agonists on yawning behaviour in rats.
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Dopamine; Dose-Response Relationship, Drug; Humans; Hydroxydopamines; Male; Olfactory Bulb; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereotyped Behavior | 1983 |
Evidence that apomorphine and pergolide induce rotation in rats by different actions on D1 and D2 receptor sites.
Topics: Animals; Antiparkinson Agents; Antipsychotic Agents; Apomorphine; Behavior, Animal; Binding Sites; Denervation; Dose-Response Relationship, Drug; Drug Interactions; Ergolines; Hydroxydopamines; Kainic Acid; Male; Oxidopamine; Pergolide; Rats; Rats, Inbred Strains; Receptors, Dopamine; Rotation; Stereotaxic Techniques | 1984 |
Effect of somatostatin and its fragments on turning behaviour induced by unilateral substantia nigra lesion in the rat.
Topics: Amphetamines; Animals; Apomorphine; Behavior, Animal; Dopamine; Dose-Response Relationship, Drug; Hydroxydopamines; Male; Oxidopamine; Peptide Fragments; Rats; Rats, Inbred Strains; Somatostatin; Substantia Nigra | 1984 |
Spontaneous recovery from motor asymmetry in adult rats with 6-hydroxydopamine-induced partial lesions of the substantia nigra.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamine; Animals; Apomorphine; Dopamine; Female; Functional Laterality; Homovanillic Acid; Hydroxydopamines; Motor Activity; Oxidopamine; Rats; Rats, Inbred Strains; Substantia Nigra; Tyrosine 3-Monooxygenase | 1984 |
Effect of GM1 ganglioside treatment on the recovery of dopaminergic nigro-striatal neurons after different types of lesion.
Topics: Animals; Apomorphine; Behavior, Animal; Corpus Striatum; G(M1) Ganglioside; Gangliosides; Hydroxydopamines; Nerve Regeneration; Neurons; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Rotation; Substantia Nigra; Tyrosine 3-Monooxygenase | 1984 |
Indirect effects of apomorphine on serotoninergic neurons in rats.
Topics: Animals; Apomorphine; Brain; Hydroxydopamines; Hydroxyindoleacetic Acid; Male; Microscopy, Fluorescence; Neurons; Oxidopamine; Rats; Rats, Inbred Strains; Serotonin | 1984 |
The effects of denervation and chronic haloperidol treatment on neostriatal dopamine receptor density are not additive in the rat.
Topics: Animals; Apomorphine; Butaclamol; Corpus Striatum; Drug Interactions; Haloperidol; Hydroxydopamines; Male; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Rotation; Spiperone | 1984 |
High- and low-affinity states of striatal D2 receptors are not affected by 6-hydroxydopamine or chronic haloperidol treatment.
Topics: Animals; Apomorphine; Butaclamol; Cinanserin; Corpus Striatum; Dopamine; Guanylyl Imidodiphosphate; Haloperidol; Hydroxydopamines; Male; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1984 |
Role of serotonin in the apomorphine-induced increase of adrenomedullary ornithine decarboxylase activity.
Topics: 5,6-Dihydroxytryptamine; Adrenal Medulla; Animals; Apomorphine; Brain Mapping; Brain Stem; Carboxy-Lyases; Dopamine; Fenclonine; Hydroxydopamines; Male; Ornithine Decarboxylase; Oxidopamine; Raphe Nuclei; Rats; Serotonin | 1982 |
Repeated apomorphine treatment causes behavioural supersensitivity and dopamine D2 receptor hyposensitivity.
Topics: Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Haloperidol; Humans; Hydroxydopamines; Kinetics; Male; Motor Activity; Muridae; Oxidopamine; Receptors, Dopamine; Receptors, Dopamine D2; Stereotyped Behavior; Substantia Nigra | 1983 |
The dopamine D-1 antagonist SCH 23390 inhibits apomorphine but not pergolide induced rotation.
Topics: Animals; Apomorphine; Behavior, Animal; Benzazepines; Ergolines; Hydroxydopamines; Male; Oxidopamine; Pergolide; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Rotation | 1984 |
Collicular picrotoxin alleviates akinesia but not sensory neglect in rats with bilateral 6-hydroxydopamine lesions of ventral midbrain.
Topics: Animals; Apomorphine; GABA Antagonists; gamma-Aminobutyric Acid; Hydroxydopamines; Male; Mesencephalon; Motor Activity; Oxidopamine; Picrotoxin; Rats; Sensation; Superior Colliculi; Synaptic Transmission | 1981 |
Plasticity of neostriatal dopamine receptors after nigrostriatal injury: relationship to recovery of sensorimotor functions and behavioral supersensitivity.
Topics: Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Humans; Hydroxydopamines; Motor Activity; Neuronal Plasticity; Oxidopamine; Rats; Receptors, Dopamine; Stereotyped Behavior; Substantia Nigra; Synaptic Transmission | 1982 |
Participation of projections from substantia nigra reticulata to the lower brain stem in tuning behavior.
Topics: Animals; Apomorphine; Behavior, Animal; Brain Stem; Hydroxydopamines; Kainic Acid; Male; Oxidopamine; Rats; Rats, Inbred Strains; Substantia Nigra; Synaptic Transmission | 1982 |
Reversible decrease in dopaminergic 3H-agonist binding after 6-hydroxydopamine and irreversible decrease after kainic acid.
Topics: Animals; Apomorphine; Caudate Nucleus; Corpus Striatum; Dopamine; Functional Laterality; Hydroxydopamines; Kainic Acid; Kinetics; Male; Oxidopamine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Opioid; Tritium | 1983 |
The anatomical substrate of the turning behaviour seen after lesions in the nigrostriatal dopamine system.
Topics: Afferent Pathways; Animals; Apomorphine; Basal Ganglia; Corpus Striatum; Dominance, Cerebral; Dopamine; Humans; Hydroxydopamines; Oxidopamine; Rats; Receptors, Dopamine; Stereotyped Behavior; Substantia Nigra; Synaptic Transmission; Thalamic Nuclei | 1983 |
Role of the ventromedial nucleus of the thalamus in motor behaviour--II. Effects of lesions.
Topics: Animals; Apomorphine; Corpus Striatum; Dominance, Cerebral; Dopamine; Female; Humans; Hydroxydopamines; Locomotion; Male; Motor Activity; Muscimol; Oxidopamine; Posture; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereotyped Behavior; Substantia Nigra; Synaptic Transmission; Thalamic Nuclei | 1983 |
Effects of chronic lithium treatment on dopamine receptors in the rat corpus striatum. II. No effect on denervation or neuroleptic-induced supersensitivity.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Chlorides; Corpus Striatum; Dopamine; Haloperidol; Humans; Hydroxydopamines; Kinetics; Lithium; Lithium Chloride; Male; Motor Activity; Neural Pathways; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Substantia Nigra | 1982 |
Irritable aggression induced by delta 9-tetrahydrocannabinol in rats pretreated with 6-hydroxydopamine.
Topics: Aggression; Animals; Apomorphine; Catecholamines; Dopamine; Dronabinol; Humans; Hydroxydopamines; Male; Methamphetamine; Norepinephrine; Oxidopamine; Rats; Rats, Inbred Strains; Serotonin; Time Factors | 1984 |
Functional recovery following transplantation of ventral mesencephalic cells in rat subjected to 6-OHDA lesions of the mesolimbic dopaminergic neurons.
Topics: Animals; Apomorphine; Dextroamphetamine; Dopamine; Hydroxydopamines; Limbic System; Male; Mesencephalon; Motor Activity; Nerve Regeneration; Nucleus Accumbens; Oxidopamine; Rats; Rats, Inbred Strains; Synaptic Transmission; Tegmentum Mesencephali | 1984 |
Effects of d-amphetamine and apomorphine upon operant behavior and schedule-induced licking in rats with 6-hydroxydopamine-induced lesions of the nucleus accumbens.
Topics: Animals; Apomorphine; Behavior, Animal; Body Weight; Brain Chemistry; Conditioning, Operant; Dextroamphetamine; Dopamine; Drug Interactions; Hydroxydopamines; Male; Motor Activity; Norepinephrine; Nucleus Accumbens; Oxidopamine; Rats; Reinforcement Schedule; Septal Nuclei | 1983 |
Apomorphine-induced changes in local cerebral blood flow in normal rats and after lesions of the dopaminergic nigrostriatal bundle.
Topics: Animals; Apomorphine; Caudate Nucleus; Cerebrovascular Circulation; Corpus Striatum; Dominance, Cerebral; Dopamine; Energy Metabolism; Hydroxydopamines; Male; Neural Pathways; Oxidopamine; Putamen; Rats; Rats, Inbred Strains; Receptors, Dopamine; Regional Blood Flow; Substantia Nigra | 1983 |
In vivo binding of N-n-propylnorapomorphine in the rat brain: regional localization, quantification in striatum and lack of correlation with dopamine metabolism.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Binding Sites; Brain; Chemical Phenomena; Chemistry; Corpus Striatum; Dopamine; Homovanillic Acid; Hydroxydopamines; Male; Oxidopamine; Rats; Rats, Inbred Strains; Time Factors | 1983 |
Posture-independent sensorimotor analysis of inter-hemispheric receptor asymmetries in neostriatum.
Topics: Animals; Apomorphine; Brain; Corpus Striatum; Dopamine; Forelimb; Functional Laterality; Hydroxydopamines; Kainic Acid; Male; Motor Activity; Oxidopamine; Posture; Radius; Rats; Receptors, Dopamine; Spiperone; Substantia Nigra; Ulna | 1983 |
Evidence for a role of endogenous opioids in the nigrostriatal system: influence of naloxone and morphine on nigrostriatal dopaminergic supersensitivity.
Topics: Amphetamine; Animals; Apomorphine; Corpus Striatum; Dopamine; Endorphins; Humans; Hydroxydopamines; Male; Morphine; Naloxone; Oxidopamine; Rats; Rats, Inbred Strains; Stereotyped Behavior; Substantia Nigra; Sympathectomy, Chemical | 1983 |
Apomorphine-induced biphasic circling behaviour in 6-hydroxydopamine-lesioned rats. A pharmacological kindling phenomenon.
Topics: Animals; Apomorphine; Female; Habituation, Psychophysiologic; Haloperidol; Humans; Hydroxydopamines; Kindling, Neurologic; Oxidopamine; Rats; Rats, Inbred Strains; Stereotyped Behavior; Time Factors | 1983 |
Effects of amphetamine and apomorphine on locomotor activity after 6-OHDA and electrolytic lesions of the nucleus accumbens septi.
Topics: Animals; Apomorphine; Dextroamphetamine; Electric Stimulation; Hydroxydopamines; Kinetics; Male; Motor Activity; Nucleus Accumbens; Oxidopamine; Rats; Rats, Inbred Strains; Septal Nuclei | 1983 |
Localization of [3H]N-propylnorapomorphine binding in mouse striatum.
Topics: Afferent Pathways; Animals; Apomorphine; Corpus Striatum; Frontal Lobe; Hydroxydopamines; Kainic Acid; Kinetics; Male; Mice; Mice, Inbred C57BL; Neural Pathways; Neurons; Oxidopamine; Receptors, Dopamine; Spiperone | 1983 |
Differential anatomical location of [3H]-N,n-propylnorapomorphine and [3H]-spiperone binding sites in the striatum and substantia nigra of the rat.
Topics: Animals; Apomorphine; Butyrophenones; Corpus Striatum; Female; Hydroxydopamines; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Substantia Nigra; Tritium | 1983 |
Dopamine receptor agonists: intrinsic activity vs. state of receptor.
Topics: Animals; Apomorphine; Brain; Denervation; Exploratory Behavior; Hydroxydopamines; Oxidopamine; Piperidines; Prolactin; Rats; Receptors, Dopamine; Stereoisomerism; Sympathectomy, Chemical | 1983 |
Dopamine inhibitory and excitatory systems in tardive dyskinesias.
Topics: Animals; Apomorphine; Disease Models, Animal; Drug Evaluation, Preclinical; Dyskinesia, Drug-Induced; Hydroxydopamines; Male; Nucleus Accumbens; Oxidopamine; Piribedil; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sulpiride | 1983 |
Rat climbing behavior elicited by stimulation of cerebral dopamine receptors.
Topics: Animals; Apomorphine; Behavior, Animal; Brain; Corpus Striatum; Dopamine; Electric Stimulation; Globus Pallidus; Hydroxydopamines; Male; Nucleus Accumbens; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stimulation, Chemical; Substantia Nigra; Sulpiride | 1984 |
Differential effects of apomorphine in 6-hydroxydopamine-treated and aged rats.
Topics: Aging; Animals; Animals, Newborn; Apomorphine; Brain Chemistry; Catecholamines; Discrimination, Psychological; Hydroxydopamines; Male; Oxidopamine; Rats; Rats, Inbred Strains | 1984 |
Lithium attenuates the development of lesion-induced behavioral supersensitivity to apomorphine.
Topics: Animals; Apomorphine; Body Weight; Corpus Striatum; Dopamine; Hydroxydopamines; Lithium; Male; Movement; Oxidopamine; Rats; Rats, Inbred Strains; Rotation; Substantia Nigra | 1984 |
Pharmacologic profile of a novel potent direct-acting dopamine agonist, (+)-4-propyl-9-hydroxynaphthoxazine [(+)-PHNO].
Topics: Adenylyl Cyclases; Animals; Apomorphine; Binding, Competitive; Body Temperature; Brain Stem; Female; Fishes; Humans; Hydroxydopamines; Mice; Motor Activity; Oxazines; Oxidopamine; Posture; Rats; Rats, Inbred Strains; Receptors, Dopamine; Retina; Spiperone; Stereotyped Behavior; Vomiting | 1984 |
Unilateral striatal dopamine denervation: reduced motor inhibitory effects of dopamine antagonists revealed in models of asymmetric and circling behaviour.
Topics: Animals; Apomorphine; Corpus Striatum; Denervation; Dopamine; Dopamine Antagonists; Electric Stimulation; Humans; Hydroxydopamines; Male; Oxidopamine; Posture; Rats; Rats, Inbred Strains; Stereotyped Behavior; Tranylcypromine | 1984 |
In vivo binding of N-n-propylnorapomorphine in the rat striatum: quantification after lesions produced by kainate, 6-hydroxydopamine and decortication.
Topics: Animals; Apomorphine; Cerebellum; Corpus Striatum; Decerebrate State; Hydroxydopamines; Kainic Acid; Kinetics; Male; Oxidopamine; Pyrrolidines; Rats; Rats, Inbred Strains | 1984 |
Effect of dopamine system activation on substantia nigra pars reticulata output neurons: variable single-unit responses in normal rats and inhibition in 6-hydroxydopamine-lesioned rats.
Topics: Animals; Apomorphine; Dopamine; Efferent Pathways; Flupenthixol; Haloperidol; Hydroxydopamines; Injections, Intravenous; Male; Neural Inhibition; Neurons; Oxidopamine; Rats; Rats, Inbred Strains; Spiperone; Substantia Nigra; Tectum Mesencephali; Thalamus | 1984 |
Repeated stress increases locomotor response to amphetamine.
Topics: 3,4-Dihydroxyphenylacetic Acid; alpha-Methyltyrosine; Amphetamine; Amygdala; Animals; Apomorphine; Cerebral Cortex; Dopamine; Humans; Hydroxydopamines; Limbic System; Male; Methyltyrosines; Motor Activity; Norepinephrine; Nucleus Accumbens; Oxidopamine; Rats; Rats, Inbred Strains; Stress, Psychological | 1984 |
Postsynaptic dopamine agonistic effects of 3-PPP enantiomers revealed by bilateral 6-hydroxy-dopamine lesions and by chronic reserpine treatment in rats.
Topics: Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Drug Interactions; Hydroxydopamines; Male; Oxidopamine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reserpine; Stereoisomerism; Stimulation, Chemical | 1984 |
Evidence for heterogeneous rotational responsiveness to apomorphine, 3-PPP and SKF 38393 in 6-hydroxydopamine-denervated rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Benzazepines; Clozapine; Ergolines; Humans; Hydroxydopamines; Male; Oxidopamine; Pergolide; Piperidines; Postural Balance; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereotyped Behavior; Sympathectomy, Chemical | 1984 |
Selective neonatal depletion of dopamine has no effect on medial prefrontal cortex self-stimulation in the rat.
Topics: Animals; Animals, Newborn; Apomorphine; Brain Chemistry; Catecholamines; Cerebral Cortex; Desipramine; Dopamine; Electric Stimulation; Haloperidol; Histocytochemistry; Hydroxydopamines; Injections, Intraventricular; Male; Oxidopamine; Rats; Rats, Inbred Strains; Self Stimulation | 1984 |
The effect of cyclo (Leu-Gly) on chemical denervation supersensitivity of dopamine receptors induced by intracerebroventricular injection of 6-hydroxydopamine in mice.
Topics: Animals; Apomorphine; Brain; Dipeptides; Dopamine; Hydroxydopamines; Injections, Intraventricular; Isomerism; Male; Mice; Neuropeptides; Oxidopamine; Peptides, Cyclic; Receptors, Dopamine | 1980 |
Amphetamine-, scopolamine- and caffeine-induced locomotor activity following 6-hydroxydopamine lesions of the mesolimbic dopamine system.
Topics: Animals; Apomorphine; Caffeine; Dextroamphetamine; Hydroxydopamines; Locomotion; Male; Nucleus Accumbens; Oxidopamine; Rats; Receptors, Dopamine; Scopolamine; Septal Nuclei | 1981 |
Drug-induced circling after unilateral 6-hydroxydopamine lesions of the nigro-striatal pathway is mediated via the midbrain periaqueductal grey and adjacent reticular formation (angular complex).
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Electrolysis; Female; Hydroxydopamines; Kainic Acid; Medial Forebrain Bundle; Mesencephalon; Motor Activity; Oxidopamine; Rats; Rats, Inbred Strains; Substantia Nigra | 1981 |
Possible involvement of nigrostriatal dopamine system in the inhibition of thyrotropin secretion in the rat.
Topics: Animals; Apomorphine; Dopamine; Dopamine Antagonists; Hydroxydopamines; Hypothalamus, Middle; Male; Norepinephrine; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Substantia Nigra; Thyrotropin | 1981 |
Critical role of midbrain reticular formation in the expression of dopamine-mediated circling behaviour.
Topics: Animals; Apomorphine; Corpus Striatum; Dopamine; Hydroxydopamines; Male; Motor Activity; Oxidopamine; Posture; Rats; Rats, Inbred Strains; Reticular Formation; Rotation; Substantia Nigra; Superior Colliculi; Tegmentum Mesencephali; Thalamus | 1981 |
A re-evaluation of the role of superior colliculus in turning behaviour.
Topics: Animals; Apomorphine; Functional Laterality; Hydroxydopamines; Kainic Acid; Male; Motor Activity; Oxidopamine; Rats; Rats, Inbred Strains; Rotation; Superior Colliculi | 1982 |
Functional validation of projection topography in the nigrostriatal dopamine system.
Topics: alpha-Methyltyrosine; Amphetamine; Animals; Apomorphine; Caudate Nucleus; Corpus Striatum; Dopamine; Female; Humans; Hydroxydopamines; Mesencephalon; Methyltyrosines; Motor Activity; Oxidopamine; Rats; Rotation; Substantia Nigra | 1982 |
A pharmacological comparison of 6,7-dihydroxy-2-dimethylaminotetralin (TL-99) and N-n-propyl-3-(3-hydroxyphenyl)piperidine with (3-PPP) selected dopamine agonists.
Topics: 4-Butyrolactone; Animals; Apomorphine; Cell Membrane; Corpus Striatum; Female; Humans; Hydroxydopamines; Naphthalenes; Oxidopamine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Tetrahydronaphthalenes | 1982 |
Effect of intracerebroventricular administration of chlorpromazine on the serum level of free fatty acids in rats.
Topics: Animals; Apomorphine; Chlorpromazine; Dopamine; Dose-Response Relationship, Drug; Fatty Acids, Nonesterified; Haloperidol; Hydroxydopamines; Injections, Intraventricular; Male; Oxidopamine; Rats; Rats, Inbred Strains; Sympathectomy, Chemical | 1982 |
Effects of vagotomy and glossopharyngectomy on respiratory response to dopamine-agonists.
Topics: Animals; Apomorphine; Blood Circulation; Carbon Dioxide; Dopamine; Dose-Response Relationship, Drug; Female; Glossopharyngeal Nerve; Haloperidol; Heart Rate; Hydroxydopamines; Hypoxia; Male; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Respiration; Vagotomy | 1982 |
Apomorphine-induced facilitation of intracranial self-stimulation following dopamine denervation of the nucleus accumbens.
Topics: Animals; Apomorphine; Dopamine; Electric Stimulation; Hydroxydopamines; Hypothalamic Area, Lateral; Locus Coeruleus; Male; Motor Activity; Neural Pathways; Norepinephrine; Nucleus Accumbens; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Self Stimulation; Septal Nuclei | 1982 |
Dopaminergic substrates of amphetamine-induced place preference conditioning.
Topics: Animals; Apomorphine; Choice Behavior; Conditioning, Operant; Corpus Striatum; Dextroamphetamine; Dopamine; Dose-Response Relationship, Drug; Haloperidol; Hydroxydopamines; Male; Motor Activity; Norepinephrine; Nucleus Accumbens; Orientation; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reinforcement Schedule | 1982 |
Multifocal brain sites for apomorphine-induced circling and other stereotyped motor behaviour in the 6-hydroxydopamine-lesioned rat.
Topics: Amygdala; Animals; Apomorphine; Brain; Caudate Nucleus; Frontal Lobe; Humans; Hydroxydopamines; Hypothalamus; Male; Median Eminence; Motor Activity; Oxidopamine; Periaqueductal Gray; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spinal Cord; Stereotyped Behavior; Substantia Nigra; Thalamic Nuclei | 1982 |
Prostaglandin inhibition of apomorphine-induced circling in mice.
Topics: Animals; Apomorphine; Brain; Corpus Striatum; Dextroamphetamine; Humans; Hydroxydopamines; Indomethacin; Injections, Intraventricular; Male; Muridae; Neural Pathways; Oxidopamine; Prostaglandins; Receptors, Dopamine; Stereotyped Behavior; Synapses | 1982 |
Effects of apomorphine on appetitive conditioning in 6-hydroxydopamine treated rat pups.
Topics: Animals; Animals, Newborn; Apomorphine; Association Learning; Brain; Choice Behavior; Conditioning, Classical; Conditioning, Operant; Desipramine; Generalization, Stimulus; Hydroxydopamines; Muridae; Oxidopamine; Receptors, Dopamine; Smell | 1982 |
Mesolimbic and mesocortical dopaminergic neurons are necessary for normal exploratory behavior in rats.
Topics: Animals; Apomorphine; Brain Mapping; Cerebral Cortex; Dopamine; Exploratory Behavior; Hydroxydopamines; Hypothalamus, Anterior; Limbic System; Nucleus Accumbens; Olfactory Bulb; Oxidopamine; Rats | 1980 |
Subthalamic nucleus lesions: widespread effects on changes in gene expression induced by nigrostriatal dopamine depletion in rats.
Topics: Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Dopamine; Enkephalins; Gene Expression Regulation; Globus Pallidus; Glutamate Decarboxylase; Male; Oxidopamine; Rats; Rats, Sprague-Dawley; RNA, Messenger; Somatostatin; Stereotyped Behavior; Substance P; Substantia Nigra; Thalamic Nuclei | 1995 |
Priming of a D1 dopamine receptor behavioural response is dissociated from striatal immediate-early gene activity.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amphetamine; Animals; Apomorphine; Base Sequence; Behavior, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Ergolines; Genes, Immediate-Early; Immunohistochemistry; Male; Molecular Sequence Data; Neostriatum; Neural Pathways; Oxidopamine; Proto-Oncogene Proteins c-fos; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Rotation; Substantia Nigra | 1995 |
Mesencephalic grafts partially restore normal nigral dynorphin levels in 6-hydroxydopamine-lesioned rats treated chronically with L-dihydroxyphenylalanine.
Topics: Amphetamine; Animals; Apomorphine; Brain Tissue Transplantation; Dihydroxyphenylalanine; Dopamine Agents; Dopamine Agonists; Dynorphins; Female; Fetal Tissue Transplantation; Image Processing, Computer-Assisted; Levodopa; Oxidopamine; Rats; Rats, Sprague-Dawley; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase | 1995 |
[The behavioral effects of dopamine agonists in rats following the intrastriatal administration of 6-hydroxydopamine].
Topics: Animals; Apomorphine; Behavior, Animal; Conditioning, Classical; Corpus Striatum; Dopamine Agonists; Dose-Response Relationship, Drug; Ergolines; Feeding Behavior; Oxidopamine; Photic Stimulation; Quinpirole; Rats | 1994 |
Sensitization to apomorphine-induced rotational behavior in 6-OHDA-lesioned rats: effects of NMDA antagonists on drug response.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Dizocilpine Maleate; Dopamine Agonists; Excitatory Amino Acid Antagonists; Male; N-Methylaspartate; Oxidopamine; Piperazines; Rats; Rats, Sprague-Dawley; Rotation; Stereotyped Behavior; Sympathectomy, Chemical | 1995 |
Intrastriatal dopamine infusion reverses compensatory increases in D2-dopamine receptors in the 6-OHDA lesioned rat.
Topics: Animals; Apomorphine; Autoradiography; Corpus Striatum; Dopamine; Functional Laterality; Infusion Pumps, Implantable; Male; Oxidopamine; Radioligand Assay; Rats; Receptors, Dopamine D2; Receptors, GABA-A; Rotation; Spiperone; Substantia Nigra; Up-Regulation | 1995 |
Reduction of apomorphine-induced rotational behaviour by subthalamic lesion in 6-OHDA lesioned rats is associated with a normalization of firing rate and discharge pattern of pars reticulata neurons.
Topics: Animals; Apomorphine; Behavior, Animal; Electrophysiology; Male; Movement; Oxidopamine; Rats; Rats, Wistar; Substantia Nigra; Thalamus | 1995 |
Graft-induced reduction in [3H]dopamine uptake into the non-lesioned striatum.
Topics: Amphetamine; Analysis of Variance; Animals; Apomorphine; Corpus Striatum; Dopamine; Fetal Tissue Transplantation; Male; Mesencephalon; Motor Activity; Oxidopamine; Rats; Rats, Wistar; Rotation; Synaptosomes; Tritium | 1995 |
7-(4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyloxy)-3,4-dihydro-2(1H)-quinolinone (OPC-14597), a new putative antipsychotic drug with both presynaptic dopamine autoreceptor agonistic activity and postsynaptic D2 receptor antagonistic activity.
Topics: 4-Butyrolactone; Animals; Antipsychotic Agents; Apomorphine; Aripiprazole; Catalepsy; Corpus Striatum; Dihydroxyphenylalanine; Dopamine Agonists; Dopamine D2 Receptor Antagonists; Drug Interactions; Male; Mice; Mice, Inbred ICR; Motor Activity; Oxidopamine; Piperazines; Presynaptic Terminals; Quinolones; Radioligand Assay; Rats; Reserpine; Spiperone; Stereotyped Behavior; Synapses; Tritium | 1995 |
Central-type benzodiazepine receptors mediate the antidopaminergic effect of clonazepam and melatonin in 6-hydroxydopamine lesioned rats: involvement of a GABAergic mechanism.
Topics: Animals; Apomorphine; Behavior, Animal; Bicuculline; Clonazepam; Corpus Striatum; Dopamine Agonists; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Isoquinolines; Male; Melatonin; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1995 |
Glial cell line-derived neurotrophic factor supports survival of injured midbrain dopaminergic neurons.
Topics: Animals; Apomorphine; Cell Survival; Dopamine; Glial Cell Line-Derived Neurotrophic Factor; Image Processing, Computer-Assisted; Immunohistochemistry; Male; Mesencephalon; Nerve Growth Factors; Nerve Tissue Proteins; Neuronal Plasticity; Neurons; Oxidopamine; Rats; Rats, Inbred F344; Stereotyped Behavior; Tyrosine 3-Monooxygenase | 1995 |
Dose-dependent lesions of the dopaminergic nigrostriatal pathway induced by intrastriatal injection of 6-hydroxydopamine.
Topics: Animals; Apomorphine; Autoradiography; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mazindol; Neural Pathways; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Substantia Nigra; Time Factors | 1995 |
Behavioral indices of moderate nigro-striatal 6-hydroxydopamine lesion: a preclinical Parkinson's model.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamine; Animals; Apomorphine; Corpus Striatum; Dopamine; Functional Laterality; Homovanillic Acid; Hydroxyindoleacetic Acid; Locomotion; Male; Motor Activity; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Wistar; Serotonin; Substantia Nigra | 1993 |
Differential cholinergic and non-cholinergic actions of acetylcholinesterase in the substantia nigra revealed by fasciculin-induced inhibition.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcholinesterase; Animals; Apomorphine; Biogenic Amines; Cell Membrane; Cholinesterase Inhibitors; Dopamine; Elapid Venoms; Functional Laterality; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Motor Activity; Norepinephrine; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Rotation; Serotonin; Substantia Nigra | 1993 |
Unilateral neonatal intracerebroventricular 6-hydroxydopamine administration in rats: I. Effects on spontaneous and drug-induced rotational behaviour and on postmortem monoamine levels.
Topics: Animals; Animals, Newborn; Apomorphine; Biogenic Monoamines; Brain Chemistry; Dextroamphetamine; Injections, Intraventricular; Male; Oxidopamine; p-Chloroamphetamine; Rats; Rats, Sprague-Dawley; Rotation; Stereotyped Behavior | 1994 |
Direct intracerebral gene transfer of an adenoviral vector expressing tyrosine hydroxylase in a rat model of Parkinson's disease.
Topics: Adenoviridae; Animals; Apomorphine; Behavior, Animal; beta-Galactosidase; Brain; Corpus Striatum; Denervation; Female; Gene Transfer Techniques; Genetic Vectors; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Recombination, Genetic; Stereotyped Behavior; Tyrosine 3-Monooxygenase | 1994 |
Dopaminergic microtransplants into the substantia nigra of neonatal rats with bilateral 6-OHDA lesions. II. Transplant-induced behavioral recovery.
Topics: Amphetamine; Animals; Apomorphine; Brain Tissue Transplantation; Cerebral Ventricles; Dopamine; Female; Fetal Tissue Transplantation; Forelimb; Functional Laterality; Injections, Intraventricular; Male; Mesencephalon; Motor Activity; Orientation; Oxidopamine; Proto-Oncogene Proteins c-fos; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Rotation; Stress, Physiological; Substantia Nigra; Tyrosine 3-Monooxygenase | 1995 |
Forelimb akinesia in the rat Parkinson model: differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analysis of Variance; Animals; Apomorphine; Brain Tissue Transplantation; Carbidopa; Dextroamphetamine; Disease Models, Animal; Dopamine; Dopamine Agonists; Ergolines; Female; Fetal Tissue Transplantation; Forelimb; Functional Laterality; Levodopa; Motor Activity; Movement Disorders; Norepinephrine; Oxidopamine; Parkinson Disease; Quinpirole; Rats; Rats, Sprague-Dawley; Rotation; Substantia Nigra; Transplantation, Heterotopic | 1995 |
Influence of novel versus home environments on sensitization to the psychomotor stimulant effects of cocaine and amphetamine.
Topics: Amphetamine; Animals; Apomorphine; Cocaine; Environment; Male; Motor Activity; Oxidopamine; Rats; Rats, Sprague-Dawley; Rotation; Stimulation, Chemical | 1995 |
6-OHDA-induced lesion of the nigrostriatal dopaminergic neurons potentiates the inhibitory effect of 7-OHDPAT, a selective D3 agonist, on acetylcholine release during striatal microdialysis in conscious rats.
Topics: Acetylcholine; Animals; Apomorphine; Corpus Striatum; Dopamine Agonists; Male; Medial Forebrain Bundle; Microdialysis; Neostriatum; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Sulpiride; Tetrahydronaphthalenes | 1994 |
Conditioned apomorphine-induced turning in 6-OHDA-lesioned rats.
Topics: Animals; Apomorphine; Conditioning, Classical; Dopamine; Environment; Male; Oxidopamine; Rats; Rats, Inbred F344; Restraint, Physical; Stereotyped Behavior; Stress, Physiological | 1994 |
Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain.
Topics: Adenoviruses, Human; Animals; Apomorphine; Behavior, Animal; beta-Galactosidase; Brain; Corpus Striatum; Cytomegalovirus; Dependovirus; Gene Expression Regulation, Viral; Genes, Reporter; Genes, Synthetic; Genetic Therapy; Genetic Vectors; Helper Viruses; Humans; Male; Microinjections; Oxidopamine; Parkinson Disease, Secondary; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Simian virus 40; Substantia Nigra; Transfection; Tyrosine 3-Monooxygenase | 1994 |
Ibotenic acid lesions of the striatum reduce drug-induced rotation in the 6-hydroxydopamine-lesioned rat.
Topics: Amphetamine; Animals; Apomorphine; Corpus Striatum; Female; Ibotenic Acid; Motor Activity; Neurons; Oxidopamine; Parvalbumins; Rats; Rats, Sprague-Dawley; Reference Values; Regression Analysis; Rotation; Substantia Nigra; Time Factors | 1994 |
Motor fluctuations in levodopa treated parkinsonian rats: relation to lesion extent and treatment duration.
Topics: Amphetamine; Animals; Apomorphine; Denervation; Immunohistochemistry; Levodopa; Male; Medial Forebrain Bundle; Movement; Neostriatum; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Rotation; Substantia Nigra; Tyrosine 3-Monooxygenase | 1994 |
Adenosine A2 receptor regulation of apomorphine-induced turning in rats with unilateral striatal dopamine denervation.
Topics: Acetylcholine; Adenosine; Animals; Antihypertensive Agents; Apomorphine; Atropine; Brain; Dopamine; Female; Naloxone; Neostriatum; Oxidopamine; Phenethylamines; Purinergic Antagonists; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrazines; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Sympathectomy, Chemical | 1993 |
Long-term sensitization of apomorphine-induced rotation behavior in rats with dopamine deafferentation or excitotoxin lesions of the striatum.
Topics: Animals; Apomorphine; Corpus Striatum; Denervation; Dopamine; Immunohistochemistry; Kainic Acid; Male; Neurons, Afferent; Oxidopamine; Rats; Rats, Sprague-Dawley; Rotation; Stereotyped Behavior; Tyrosine 3-Monooxygenase | 1993 |
Effect of bilateral 6-OHDA lesions of the substantia nigra on locomotor activity in the rat.
Topics: Amphetamine; Animals; Apomorphine; Body Weight; Immunohistochemistry; Levodopa; Male; Motor Activity; Nerve Fibers; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Inbred F344; Substantia Nigra; Tyrosine 3-Monooxygenase | 1994 |
Role of a 35 kDa fos-related antigen (FRA) in the long-term induction of striatal dynorphin expression in the 6-hydroxydopamine lesioned rat.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Atropine; Base Sequence; Corpus Striatum; Dizocilpine Maleate; Dopamine; Dynorphins; Ergolines; Gene Expression Regulation; Genes, fos; Genes, Immediate-Early; Genes, jun; Immediate-Early Proteins; Male; Molecular Sequence Data; Nerve Tissue Proteins; Oxidopamine; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Quinpirole; Rats; Rats, Inbred F344; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 1994 |
Fetal mesencephalic grafts influence the dopamine release in the non-lesioned striatum of 6-OHDA-lesioned rats: a behavioral and in vivo voltammetric study.
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Brain Tissue Transplantation; Dopamine; Electrophysiology; Female; Fetal Tissue Transplantation; Male; Mesencephalon; Neostriatum; Oxidopamine; Pargyline; Pregnancy; Rats; Rats, Wistar | 1994 |
3-O-methyl-DOPA is not involved in the development of behavioral supersensitivity after repeated L-dopa administration in 6-OHDA lesioned rats.
Topics: Animals; Apomorphine; Carbidopa; Catechol O-Methyltransferase Inhibitors; Corpus Striatum; Levodopa; Male; Methyldopa; Motor Activity; Oxidopamine; Rats; Rats, Wistar; Receptors, Dopamine; Stereotyped Behavior; Substantia Nigra | 1994 |
Transmitter-loaded polymeric microspheres induce regrowth of dopaminergic nerve terminals in striata of rats with 6-OH-DA induced parkinsonism.
Topics: Animals; Apomorphine; Capsules; Dopamine; Immunohistochemistry; Lactic Acid; Male; Microspheres; Neostriatum; Nerve Endings; Nerve Fibers; Neurotransmitter Agents; Norepinephrine; Oxidopamine; Parkinson Disease, Secondary; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Sprague-Dawley; Stereotyped Behavior | 1994 |
SKF-10,047 reverses stress-induced motor suppression: interaction with dopaminergic system.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anticonvulsants; Apomorphine; Dopamine; Electroshock; Guanidines; Male; Methamphetamine; Mice; Mice, Inbred Strains; Motor Activity; Oxidopamine; Pentazocine; Phenazocine; Pimozide; Pyrimidines; Receptors, sigma; Stress, Psychological | 1994 |
Picolinic acid blocks the neurotoxic but not the neuroexcitant properties of quinolinic acid in the rat brain: evidence from turning behaviour and tyrosine hydroxylase immunohistochemistry.
Topics: Animals; Apomorphine; Dextroamphetamine; Dopamine; Dose-Response Relationship, Drug; Immunohistochemistry; Male; Neostriatum; Neurotoxins; Oxidopamine; Picolinic Acids; Quinolinic Acid; Rats; Rats, Wistar; Stereotyped Behavior; Substantia Nigra; Tyrosine 3-Monooxygenase | 1994 |
Electrophysiological effects of SKF 38393 in rats with reserpine treatment and 6-hydroxydopamine-induced nigrostriatal lesions reveal two types of plasticity in D1 dopamine receptor modulation of basal ganglia output.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Basal Ganglia; Ergolines; Male; Neuronal Plasticity; Oxidopamine; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Reserpine; Substantia Nigra | 1994 |
The effects of chronic continuous versus intermittent levodopa treatments on striatal and extrastriatal D1 and D2 dopamine receptors and dopamine uptake sites in the 6-hydroxydopamine lesioned rat--an autoradiographic study.
Topics: Animals; Apomorphine; Autoradiography; Behavior, Animal; Benzazepines; Dopamine; Levodopa; Male; Mazindol; Medial Forebrain Bundle; Neostriatum; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Stereotyped Behavior; Sulpiride | 1994 |
Transmitter release from transplants of fetal ventral mesencephalon or locus coeruleus in the rat frontal cortex and nucleus accumbens: effects of pharmacological and behaviorally activating stimuli.
Topics: Animals; Apomorphine; Appetite; Brain Tissue Transplantation; Cerebral Ventricles; Dopamine; Female; Fetal Tissue Transplantation; Frontal Lobe; Locus Coeruleus; Mesencephalon; Neurons; Nomifensine; Norepinephrine; Nucleus Accumbens; Oxidopamine; Potassium Chloride; Rats; Rats, Sprague-Dawley; Tegmentum Mesencephali; Tetrodotoxin; Time Factors; Transplantation, Heterotopic | 1994 |
Allogeneic grafts of fetal dopamine neurons: behavioral indices of immunological interactions.
Topics: Animals; Apomorphine; Behavior, Animal; Brain Tissue Transplantation; Dopamine; Fetal Tissue Transplantation; Neostriatum; Neurons; Oxidopamine; Rats; Rats, Inbred F344; Rats, Inbred WF; Stereotyped Behavior | 1994 |
Intracerebral grafting of genetically modified cells. Applications to a rat model of Parkinson's disease.
Topics: Animals; Apomorphine; Corpus Striatum; Fibroblasts; Genetic Engineering; Oxidopamine; Parkinson Disease, Secondary; Rats; Stereotyped Behavior; Transfection; Tyrosine 3-Monooxygenase | 1993 |
Long-term correction of rat model of Parkinson's disease by gene therapy.
Topics: Animals; Animals, Newborn; Apomorphine; Brain; Cells, Cultured; Dopamine; Drug Carriers; Female; Genetic Therapy; Levodopa; Motor Activity; Muscles; Oxidopamine; Parkinson Disease, Secondary; Phosphatidylethanolamines; Plasmids; Rats; Rats, Sprague-Dawley; Time Factors; Transplantation, Heterotopic; Tyrosine 3-Monooxygenase | 1993 |
Quantitation of the levels of tyrosine hydroxylase and preproenkephalin mRNAs in nigrostriatal sites after 6-hydroxydopamine lesions.
Topics: Animals; Apomorphine; Brain Diseases; Corpus Striatum; Dopamine; Enkephalins; Gene Expression; Male; Neurons; Oxidopamine; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substantia Nigra; Tyrosine 3-Monooxygenase | 1993 |
Adrenal medulla grafts in the hemiparkinsonian rat: profile of behavioral recovery predicts restoration of the symmetry between the two striata in measures of pre- and postsynaptic dopamine function.
Topics: Adrenal Medulla; Amphetamine; Animals; Apomorphine; Benzazepines; Cerebral Ventricles; Corpus Striatum; Denervation; Female; Functional Laterality; In Situ Hybridization; Motor Activity; Oxidopamine; Parkinson Disease, Secondary; Rats; Receptors, Dopamine D2; RNA, Messenger; Rotation; Spiperone; Substantia Nigra; Transplantation, Heterotopic; Tyrosine 3-Monooxygenase | 1993 |
Neuropeptide messenger RNA expression in the 6-hydroxydopamine-lesioned rat striatum reinnervated by fetal dopaminergic transplants: differential effects of the grafts on preproenkephalin, preprotachykinin and prodynorphin messenger RNA levels.
Topics: Animals; Apomorphine; Autoradiography; Behavior, Animal; Brain Tissue Transplantation; Dopamine; Enkephalins; Female; Fetal Tissue Transplantation; In Situ Hybridization; Neostriatum; Neuropeptides; Oxidopamine; Piperazines; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stereotyped Behavior; Sympathectomy, Chemical; Tachykinins | 1993 |
Dopamine agonists and stress produce different patterns of Fos-like immunoreactivity in the lateral habenula.
Topics: Animals; Apomorphine; Dextroamphetamine; Dopamine; Environment; Haloperidol; Immunohistochemistry; Lithium Chloride; Male; Nalidixic Acid; Naphthyridines; Neostriatum; Oncogene Proteins v-fos; Oxidopamine; Prosencephalon; Rats; Rats, Sprague-Dawley; Restraint, Physical; Stress, Psychological; Substantia Nigra; Thalamus | 1994 |
Asymmetrical orientation to edges of an openfield: modulation by striatal dopamine and relationship to motor asymmetries in the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamine; Animals; Apomorphine; Dopamine; Exploratory Behavior; Functional Laterality; Male; Motor Activity; Neostriatum; Orientation; Oxidopamine; Rats; Rats, Sprague-Dawley; Rotation; Stereotyped Behavior | 1994 |
Intranigral injections of SCH 23390 inhibit amphetamine-induced rotational behavior.
Topics: Amphetamine; Analysis of Variance; Animals; Apomorphine; Benzazepines; Corpus Striatum; Dose-Response Relationship, Drug; Male; Microinjections; Motor Activity; Oxidopamine; Rats; Rats, Sprague-Dawley; Rotation; Stereotaxic Techniques; Substantia Nigra; Sulpiride; Time Factors | 1993 |
Time-course of changes in striatal levels of DA uptake sites, DA D2 receptor and preproenkephalin mRNAs after nigrostriatal dopaminergic denervation in the rat.
Topics: Animals; Apomorphine; Biological Transport; Corpus Striatum; Dopamine; Enkephalins; In Situ Hybridization; Male; Motor Activity; Neurons; Oxidopamine; Piperazines; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; RNA, Messenger; Substantia Nigra; Time Factors | 1993 |
Restoration of complex sensorimotor behavior and skilled forelimb use by a modified nigral cell suspension transplantation approach in the rat Parkinson model.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Behavior, Animal; Brain Tissue Transplantation; Caudate Nucleus; Corpus Striatum; Denervation; Dextroamphetamine; Dopamine; Ergolines; Feeding Behavior; Female; Fetal Tissue Transplantation; Forelimb; Motor Activity; Orientation; Oxidopamine; Parkinson Disease, Secondary; Putamen; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Regression Analysis; Rotation; Substantia Nigra | 1993 |
Transection of corticostriatal afferents reduces amphetamine- and apomorphine-induced striatal Fos expression and turning behaviour in unilaterally 6-hydroxydopamine-lesioned rats.
Topics: Afferent Pathways; Amphetamine; Animals; Apomorphine; Behavior, Animal; Cerebral Cortex; Corpus Striatum; Denervation; Female; Frontal Lobe; Oxidopamine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Stereotyped Behavior | 1993 |
Correlation of apomorphine- and amphetamine-induced turning with nigrostriatal dopamine content in unilateral 6-hydroxydopamine lesioned rats.
Topics: Amphetamine; Animals; Apomorphine; Corpus Striatum; Dopamine; Female; Male; Motor Activity; Oxidopamine; Parkinson Disease; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Rotation; Substantia Nigra; Ventral Tegmental Area | 1993 |
Dopaminergic grafts implanted into the neonatal or adult striatum: comparative effects on rotation and paw reaching deficits induced by subsequent unilateral nigrostriatal lesions in adulthood.
Topics: Aging; Amphetamine; Animals; Animals, Newborn; Apomorphine; Behavior, Animal; Brain Tissue Transplantation; Corpus Striatum; Denervation; Dopamine; Fetal Tissue Transplantation; Immunohistochemistry; Mesencephalon; Neural Pathways; Neurons; Oxidopamine; Rats; Rats, Sprague-Dawley; Rotation; Stereotyped Behavior; Substantia Nigra; Telencephalon | 1993 |
Ceruletide suppresses rotational behavior in lesioned rats via CCKA receptors.
Topics: Animals; Apomorphine; Benzodiazepinones; Ceruletide; Devazepide; Male; Motor Activity; Oxidopamine; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin | 1993 |
Opposite effects of intranigral ibotenic acid and 6-hydroxydopamine on motor behavior and on striatal neuropeptide Y neurons.
Topics: Animals; Apomorphine; Caudate Nucleus; Corpus Callosum; Corpus Striatum; Globus Pallidus; Ibotenic Acid; Male; Microinjections; Motor Activity; Neurons; Neuropeptide Y; Nucleus Accumbens; Oxidopamine; Putamen; Rats; Rats, Wistar; Reference Values; Substantia Nigra | 1993 |
Quantitative electromyographic changes following modification of central dopaminergic transmission.
Topics: Animals; Apomorphine; Electromyography; Hindlimb; Male; Muscle Denervation; Muscle Tonus; Muscles; Oxidopamine; Rats; Rats, Sprague-Dawley; Reserpine | 1993 |
Dopamine-rich grafts in the neostriatum and/or nucleus accumbens: effects on drug-induced behaviours and skilled paw-reaching.
Topics: Amphetamine; Animals; Apomorphine; Brain Tissue Transplantation; Dopamine; Female; Fetal Tissue Transplantation; Immunohistochemistry; Mesencephalon; Motor Activity; Neostriatum; Nucleus Accumbens; Oxidopamine; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Sympathectomy, Chemical | 1993 |
Partial 6-hydroxydopamine-induced lesions and haloperidol-induced catalepsy.
Topics: Aging; Animals; Apomorphine; Brain Chemistry; Catalepsy; Corpus Striatum; Dose-Response Relationship, Drug; Female; Haloperidol; Oxidopamine; Rats; Rats, Sprague-Dawley | 1993 |
Role of the corpus callosum in expression of behavioral asymmetries induced by a unilateral dopamine lesion of the substantia nigra in the rat.
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Competitive Behavior; Corpus Callosum; Dopamine; Escape Reaction; Exploratory Behavior; Functional Laterality; Male; Oxidopamine; Rats; Stereotyped Behavior; Substantia Nigra | 1993 |
Lamotrigine has no antiparkinsonian activity in rat models of Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Apomorphine; Dose-Response Relationship, Drug; Lamotrigine; Male; Motor Activity; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar; Reserpine; Rotation; Stereotyped Behavior; Substantia Nigra; Sympatholytics; Triazines | 1995 |
Dopamine receptor agonists regulate levels of the serotonin 5-HT2A receptor and its mRNA in a subpopulation of rat striatal neurons.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adrenergic Agents; Amphetamines; Animals; Animals, Newborn; Apomorphine; Autoradiography; Binding, Competitive; Dopamine Agonists; Enkephalins; Female; In Situ Hybridization; Iodine Radioisotopes; Microinjections; Motor Activity; Neostriatum; Neurons; Oxidopamine; Pregnancy; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Serotonin; RNA, Messenger; Serotonin Receptor Agonists | 1996 |
Administration of amphetamine does not increase the functional efficacy of dopaminergic grafts made in infancy.
Topics: Amphetamine; Analysis of Variance; Animals; Apomorphine; Brain Tissue Transplantation; Conditioning, Psychological; Dopamine; Fetal Tissue Transplantation; Male; Mesencephalon; Motor Activity; Neostriatum; Neurons; Oxidopamine; Pain; Rats; Rats, Wistar; Telencephalon | 1996 |
Time course of striatal changes induced by 6-hydroxydopamine lesion of the nigrostriatal pathway, as studied by combined evaluation of rotational behaviour and striatal Fos expression.
Topics: Amphetamine; Animals; Apomorphine; Corpus Striatum; Female; Immunohistochemistry; Oxidopamine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Rotation; Stereotyped Behavior; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase | 1996 |
Intrastriatal injection of GDNF attenuates the effects of 6-hydroxydopamine.
Topics: Amphetamine; Animals; Apomorphine; Dopamine Agents; Dopamine Agonists; Female; Glial Cell Line-Derived Neurotrophic Factor; Immunohistochemistry; Injections; Neostriatum; Nerve Growth Factors; Nerve Tissue Proteins; Oxidopamine; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Sympatholytics | 1996 |
Reduced ageing effects of striatal neuronal discharge rate by aged ventral mesencephalic grafts.
Topics: Aging; Animals; Apomorphine; Brain Tissue Transplantation; Dopamine Agonists; Electrophysiology; Female; Fetal Tissue Transplantation; Immunohistochemistry; Mesencephalon; Neostriatum; Nerve Regeneration; Neurons; Oxidopamine; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Sympathectomy, Chemical; Sympatholytics; Tyrosine 3-Monooxygenase | 1996 |
Intrastriatal injection of opioid receptor agonists inhibits apomorphine-induced behavior in 6-hydroxydopamine-treated mice.
Topics: Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Dopamine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Naltrexone; Oxidopamine; Peptide Fragments; Receptors, Opioid | 1995 |
(-)-Stepholidine acts as a D1 partial agonist on firing activity of substantia nigra pars reticulata neurons in 6-hydroxydopamine-lesioned rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Benzazepines; Berberine; Dopamine Agonists; Electrophysiology; Haloperidol; Male; Membrane Potentials; Microelectrodes; Neurons; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Reserpine; Substantia Nigra | 1996 |
Effects of neonatal dopamine depletion on sensory inhibition in the rat.
Topics: Animals; Animals, Newborn; Apomorphine; Auditory Perception; Brain Chemistry; Catecholamines; Dextroamphetamine; Dopamine; Dopamine Agents; Dopamine Agonists; Electrodes, Implanted; Electrophysiology; Evoked Potentials, Auditory; Male; Oxidopamine; Rats; Rats, Sprague-Dawley; Sensation; Sympatholytics | 1996 |
Reversal of behavioural abnormalities by fetal allografts in a novel rat model of striatonigral degeneration.
Topics: Amphetamines; Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Fetal Tissue Transplantation; Graft Survival; Immunohistochemistry; Male; Mesencephalon; Nerve Degeneration; Oxidopamine; Quinolinic Acid; Rats; Rats, Wistar; Substantia Nigra; Transplantation, Homologous | 1996 |
Rapid eye movement (REM) sleep deprivation in 6-OHDA nigro-striatal lesioned rats with and without transplants of dissociated chromaffin cells.
Topics: Animals; Apomorphine; Behavior, Animal; Cerebral Cortex; Chromaffin Cells; Corpus Striatum; Immunohistochemistry; Male; Oxidopamine; Rats; Rats, Wistar; Sleep Deprivation; Sleep, REM | 1996 |
Changes in apomorphine pharmacodynamics following repeated treatment in 6-hydroxydopamine-lesioned rats.
Topics: Animals; Apomorphine; Behavior, Animal; Dose-Response Relationship, Drug; Male; Motor Activity; Oxidopamine; Rats; Rats, Sprague-Dawley | 1996 |
Effect of MK 801 on priming of D1-dependent contralateral turning and its relationship to c-fos expression in the rat caudate-putamen.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Caudate Nucleus; Dizocilpine Maleate; Dopamine Agonists; Excitatory Amino Acid Antagonists; Immunohistochemistry; Male; N-Methylaspartate; Oxidopamine; Proto-Oncogene Proteins c-fos; Putamen; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Stereotyped Behavior; Sympathectomy, Chemical; Sympatholytics; Synaptic Transmission | 1996 |
Neuroprotective effects of riluzole on a model of Parkinson's disease in the rat.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amphetamine; Animals; Apomorphine; Brain Chemistry; Central Nervous System Stimulants; Conditioning, Operant; Dopamine Agonists; Female; Male; Neuroprotective Agents; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Inbred Strains; Riluzole; Stereotyped Behavior; Substantia Nigra; Sympatholytics; Thiazoles | 1996 |
Reversal of levodopa-induced motor fluctuations in experimental parkinsonism by NMDA receptor blockade.
Topics: Animals; Antiparkinson Agents; Apomorphine; Benserazide; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Injections; Injections, Intraventricular; Levodopa; Male; Movement; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rotation; Stereotyped Behavior; Substantia Nigra | 1995 |
Modulation of dopaminergic neurotransmission in the 6-hydroxydopamine lesioned rotational model by peptidomimetic analogues of L-prolyl-L-leucyl-glycinamide.
Topics: Animals; Apomorphine; Behavior, Animal; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Male; MSH Release-Inhibiting Hormone; Neuropeptides; Oxidopamine; Rats; Rats, Wistar; Rotation; Sympatholytics; Synaptic Transmission | 1996 |
The D1 receptor-mediated effects of the ergoline derivative LEK-8829 in rats with unilateral 6-hydroxydopamine lesions.
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Benzazepines; Dose-Response Relationship, Drug; Genes, fos; Haloperidol; Lysergic Acid; Male; Oxidopamine; Pindolol; Rats; Rats, Wistar; Receptors, Dopamine D1 | 1996 |
Rotational behaviour and neurochemical changes in unilateral N-methyl-norsalsolinol and 6-hydroxydopamine lesioned rats.
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Catecholamines; Corpus Striatum; Female; Isoquinolines; Monoamine Oxidase; Oxidopamine; Rats; Rats, Wistar; Rotation; Stereoisomerism; Stereotyped Behavior; Substantia Nigra; Tetrahydroisoquinolines | 1996 |
The behavioral effects of habituation and challenge with apomorphine after 6-OHDA lesioning of the nucleus accumbens in rats.
Topics: Adrenocorticotropic Hormone; Amino Acid Sequence; Animals; Anticonvulsants; Apomorphine; Behavior, Animal; Dopamine Agonists; Habituation, Psychophysiologic; Male; Molecular Sequence Data; Motor Activity; Nucleus Accumbens; Oxidopamine; Peptide Fragments; Rats; Rats, Wistar; Sympathectomy, Chemical | 1995 |
SDZ GLC 756, a novel octahydrobenzo[g]quinoline derivative exerts opposing effects on dopamine D1 and D2 receptors.
Topics: Acetylcholine; Adenylyl Cyclases; Animals; Apomorphine; Cattle; Cerebral Cortex; Dopamine; Dopamine Agents; Dopamine Agonists; In Vitro Techniques; Male; Mice; Muscle, Smooth, Vascular; Neostriatum; Norepinephrine; Oxidopamine; Prolactin; Quinolines; Radioligand Assay; Rats; Receptors, Dopamine D1; Receptors, Dopamine D2; Serotonin; Stereotyped Behavior; Sympatholytics | 1996 |
Drug-free evaluation of rat models of parkinsonism and nigral grafts using a new automated rotarod test.
Topics: Amphetamine; Animals; Apomorphine; Automation; Brain Tissue Transplantation; Female; Fetal Tissue Transplantation; Mesencephalon; Motor Activity; Oxidopamine; Parkinson Disease, Secondary; Prosencephalon; Rats; Rats, Sprague-Dawley; Reference Values; Rotation; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase | 1997 |
Levels of stimulatory G protein are increased in the rat striatum after neonatal lesion of dopamine neurons.
Topics: Adenylyl Cyclases; Animals; Animals, Newborn; Apomorphine; Benzazepines; Corpus Striatum; Denervation; Dopamine; GTP-Binding Proteins; Male; Motor Activity; Neurons; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1 | 1997 |
Enhancement of the behavioral response to apomorphine administration following repeated treatment in the 6-hydroxydopamine-lesioned rat is temporally correlated with a rise in striatal preproenkephalin-B, but not preproenkephalin-A, gene expression.
Topics: Adrenergic Agents; Animals; Apomorphine; Caudate Nucleus; Corpus Striatum; Enkephalins; Gene Expression Regulation; Hyperkinesis; Locomotion; Male; Nucleus Accumbens; Oxidopamine; Protein Precursors; Putamen; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; RNA, Messenger; Rotation; Time Factors | 1997 |
Apomorphine priming alters the response of striatal outflow pathways to D2 agonist stimulation in 6-hydroxydopamine-lesioned rats.
Topics: Animals; Apomorphine; Axonal Transport; Basal Ganglia; Benzazepines; Corpus Striatum; Dopamine Agonists; Functional Laterality; Gold Colloid; Male; Models, Neurological; Motor Activity; Neurons; Oxidopamine; Proto-Oncogene Proteins c-fos; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Rotation; Salicylamides; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate | 1997 |
Modulation of apomorphine-induced rotations in unilaterally 6-hydroxydopamine lesioned rats by cholinergic agonists and antagonists.
Topics: Animals; Apomorphine; Atropine; Behavior, Animal; Cholinergic Agonists; Cholinergic Antagonists; Dose-Response Relationship, Drug; Male; Mecamylamine; Nicotine; Oxidopamine; Oxotremorine; Rats; Rats, Wistar; Sulpiride | 1997 |
Differential interaction of competitive NMDA and AMPA antagonists with selective dopamine D-1 and D-2 agonists in a rat model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apomorphine; Dopamine Agonists; Drug Interactions; Excitatory Amino Acid Antagonists; Male; Oxidopamine; Parkinson Disease, Secondary; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Rotation; Stereotyped Behavior | 1997 |
The effect of nigral implantation on sensitization to dopamine agonists in 6-hydroxydopamine-lesioned rats.
Topics: Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Female; Locomotion; Male; Oxidopamine; Pregnancy; Rats; Rats, Sprague-Dawley; Substantia Nigra | 1997 |
GTP regulation of (-)-stepholidine binding to R(H) of D1 dopamine receptors in calf striatum.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Benzazepines; Berberine; Binding, Competitive; Cattle; Corpus Striatum; Guanosine Triphosphate; Male; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Rotation; Spiperone | 1997 |
Involvement of receptor reserve in D1 agonistic action of (-)-stepholidine in lesioned rats.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Berberine; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Male; Oxidopamine; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Rotation | 1997 |
In vivo microdialysis studies on somatodendritic dopamine release in the rat substantia nigra: effects of unilateral 6-OHDA lesions and GDNF.
Topics: Animals; Apomorphine; Behavior, Animal; Dendrites; Dopamine; Dopamine Agonists; Glial Cell Line-Derived Neurotrophic Factor; Male; Microdialysis; Motor Activity; Nerve Growth Factors; Nerve Tissue Proteins; Neuroprotective Agents; Oxidopamine; Rats; Rats, Inbred F344; Reference Values; Stereotyped Behavior; Stimulation, Chemical; Substantia Nigra | 1997 |
Apomorphine is a potent radical scavenger and protects cultured pheochromocytoma cells from 6-OHDA and H2O2-induced cell death.
Topics: Adrenal Gland Neoplasms; Animals; Apomorphine; Cell Death; Free Radical Scavengers; Hydrogen Peroxide; Kinetics; Oxidopamine; PC12 Cells; Pheochromocytoma; Rats | 1998 |
Behavioral and neurochemical dynamics of neurotoxic meso-striatal dopamine lesions.
Topics: Animals; Apomorphine; Behavior, Animal; Dopamine; Dopamine Agonists; Locomotion; Male; Neostriatum; Neurotoxins; Oxidopamine; Rats; Rats, Wistar | 1997 |
Substantia nigra pars reticulata single unit activity in normal and 60HDA-lesioned rats: effects of intrastriatal apomorphine and subthalamic lesions.
Topics: Animals; Apomorphine; Corpus Striatum; Dopamine Agonists; Kainic Acid; Male; Neurons; Neurotoxins; Oxidopamine; Rats; Rats, Sprague-Dawley; Reference Values; Substantia Nigra; Thalamic Nuclei | 1997 |
Glutamic acid decarboxylase gene expression in the dopamine-denervated striatum: effects of intrastriatal fetal nigral transplants or chronic apomorphine treatment.
Topics: Animals; Apomorphine; Autoradiography; Brain Tissue Transplantation; Corpus Striatum; Denervation; Dopamine; Female; Fetal Tissue Transplantation; Glutamate Decarboxylase; Isoenzymes; Neurons; Oxidopamine; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substantia Nigra; Sulfur Radioisotopes; Transcription, Genetic | 1997 |
Modulation of dopamine receptor agonist-induced rotational behavior in 6-OHDA-lesioned rats by a peptidomimetic analogue of Pro-Leu-Gly-NH2 (PLG).
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Brain; Dopamine; Dopamine Agonists; Drug Synergism; Levodopa; Male; MSH Release-Inhibiting Hormone; Oxidopamine; Pyrrolidinones; Quinpirole; Rats; Rats, Sprague-Dawley; Stereotyped Behavior | 1997 |
Intracerebral transplantation of testis-derived sertoli cells promotes functional recovery in female rats with 6-hydroxydopamine-induced hemiparkinsonism.
Topics: Animals; Apomorphine; Corpus Striatum; Dominance, Cerebral; Female; Graft Enhancement, Immunologic; Locomotion; Male; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Sertoli Cells; Sex Characteristics; Substantia Nigra; Transplantation, Heterotopic | 1997 |
An automated rotarod method for quantitative drug-free evaluation of overall motor deficits in rat models of parkinsonism.
Topics: Animals; Apomorphine; Automation; Brain; Disease Models, Animal; Equipment Design; Female; Motor Activity; Oxidopamine; Parkinson Disease, Secondary; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Reference Values; Reproducibility of Results | 1997 |
Adenoviral vector-mediated GDNF gene therapy in a rodent lesion model of late stage Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adenoviridae; Animals; Apomorphine; Behavior, Animal; Disease Models, Animal; Dopamine; Dopamine Agonists; Enzyme-Linked Immunosorbent Assay; Female; Genetic Therapy; Genetic Vectors; Glial Cell Line-Derived Neurotrophic Factor; Humans; Nerve Growth Factors; Nerve Regeneration; Nerve Tissue Proteins; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar; Substantia Nigra; Sympatholytics | 1997 |
Intrastriatal mesencephalic grafts affect neuronal activity in basal ganglia nuclei and their target structures in a rat model of Parkinson's disease.
Topics: Animals; Apomorphine; Basal Ganglia; Brain Tissue Transplantation; Corpus Striatum; Dopamine; Dopamine Agonists; Electron Transport Complex IV; Fetal Tissue Transplantation; Graft Survival; Male; Mesencephalon; Neurons; Oxidopamine; Parkinson Disease; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Stereotyped Behavior | 1998 |
Fixed-ratio discrimination training as replacement therapy in Parkinson's disease: studies in a 6-hydroxydopamine-treated rat model.
Topics: Amphetamine; Animals; Apomorphine; Conditioning, Operant; Corpus Striatum; Discrimination Learning; Disease Models, Animal; Dopamine; Dopamine Agents; Male; Motor Activity; Neurotoxins; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Reinforcement Schedule | 1998 |
D1-Receptor-related priming is attenuated by antisense-meditated 'knockdown' of fosB expression.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Corpus Striatum; DNA-Binding Proteins; Early Growth Response Protein 1; Gene Expression Regulation; Genes, Immediate-Early; Immediate-Early Proteins; Male; Motor Activity; Oligonucleotides, Antisense; Oxidopamine; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Rats, Wistar; Receptors, Dopamine D1; Stereotyped Behavior; Transcription Factors; Transcription, Genetic | 1998 |
Cross-sensitization between footshock stress and apomorphine on self-injurious behavior and neostriatal catecholamines in a rat model of Lesch-Nyhan syndrome.
Topics: Animals; Animals, Newborn; Apomorphine; Catecholamines; Disease Models, Animal; Dopamine Agonists; Electroshock; Injections, Intraventricular; Lesch-Nyhan Syndrome; Male; Neostriatum; Neurotoxins; Oxidopamine; Rats; Rats, Sprague-Dawley; Self-Injurious Behavior; Stress, Physiological | 1998 |
Dopamine depletion in nucleus accumbens influences locomotion but not force and timing of operant responding.
Topics: Amphetamine; Animals; Apomorphine; Conditioning, Operant; Dopamine; Dopamine Agonists; Dopamine Uptake Inhibitors; Male; Motor Activity; Nucleus Accumbens; Oxidopamine; Rats | 1998 |
Effects of repeated administration of l-DOPA and apomorphine on circling behavior and striatal dopamine formation.
Topics: Animals; Apomorphine; Chromatography, High Pressure Liquid; Dopamine; Dopamine Agents; Dopamine Agonists; Electrochemistry; Levodopa; Male; Microdialysis; Neostriatum; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Substantia Nigra | 1998 |
The role of dopamine in the expression of morphine withdrawal.
Topics: Adrenergic Agents; Analgesia; Analgesics, Opioid; Analysis of Variance; Animals; Apomorphine; Dopamine; Dopamine Agents; Dopamine Antagonists; Hypothermia; Levodopa; Male; Mice; Morphine; Naloxone; Narcotic Antagonists; Oxidopamine; Substance Withdrawal Syndrome | 1998 |
Topographical organization of opioid peptide precursor gene expression following repeated apomorphine treatment in the 6-hydroxydopamine-lesioned rat.
Topics: Animals; Apomorphine; Brain; Caudate Nucleus; Disease Models, Animal; Enkephalins; Gene Expression Regulation; In Situ Hybridization; Male; Motor Activity; Nucleus Accumbens; Organ Specificity; Oxidopamine; Parkinson Disease; Protein Precursors; Putamen; Rats; Rats, Sprague-Dawley; Reference Values; Time Factors | 1998 |
Apomorphine enantiomers protect cultured pheochromocytoma (PC12) cells from oxidative stress induced by H2O2 and 6-hydroxydopamine.
Topics: Animals; Apomorphine; Cell Survival; Dopamine Agonists; Dose-Response Relationship, Drug; Humans; Hydrogen Peroxide; Lipid Peroxidation; Neuroprotective Agents; Neurotoxins; Oxidants; Oxidative Stress; Oxidopamine; PC12 Cells; Rats; Reactive Oxygen Species; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured | 1998 |
Asymmetry of sympathetic activity in a rat model of Parkinson's disease induced by 6-hydroxydopamine: haemodynamic, electrocardiographic and biochemical changes.
Topics: Animals; Apomorphine; Behavior, Animal; Catecholamines; Disease Models, Animal; Electrocardiography; Functional Laterality; Hemodynamics; Immunohistochemistry; Male; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar; Substantia Nigra; Sympathetic Nervous System; Tyrosine 3-Monooxygenase | 1998 |
Chronic levodopa is not toxic for remaining dopamine neurons, but instead promotes their recovery, in rats with moderate nigrostriatal lesions.
Topics: Amphetamine; Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Carrier Proteins; Disease Models, Animal; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Iodine Radioisotopes; Levodopa; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Fibers; Nerve Tissue Proteins; Neuropeptides; Neurotransmitter Agents; Oxidopamine; Parkinson Disease, Secondary; Prosencephalon; Radioimmunoassay; Rats; Rats, Wistar; Substantia Nigra; Sulpiride; Sympatholytics; Tyrosine 3-Monooxygenase; Ventral Tegmental Area; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 1998 |
Opposite rotation induced by dopamine agonists in rats with unilateral lesions of the globus pallidus or substantia nigra.
Topics: Animals; Apomorphine; Dextroamphetamine; Dopamine Agonists; Dopamine Uptake Inhibitors; Functional Laterality; Globus Pallidus; Male; Oxidopamine; Rats; Rats, Wistar; Stereotyped Behavior; Substantia Nigra | 1998 |
Behavioral responsitivity to dopamine receptor agonists after extensive striatal dopamine lesions during development.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analysis of Variance; Animals; Animals, Newborn; Apomorphine; Behavior, Animal; Corpus Striatum; Critical Period, Psychological; Dopamine; Dopamine Agonists; Dyskinesia, Drug-Induced; Female; Grooming; Male; Motor Activity; Mouth; Observation; Oxidopamine; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Self-Injurious Behavior; Stereotyped Behavior | 1998 |
Intrastriatal transplantation of rat adrenal chromaffin cells seeded on microcarrier beads promote long-term functional recovery in hemiparkinsonian rats.
Topics: Adrenal Glands; Animals; Antibodies; Antiparkinson Agents; Apomorphine; Astrocytes; Behavior, Animal; Cell Transplantation; Chromaffin Cells; Chromogranin A; Chromogranins; Complement C3b; Corpus Striatum; Glial Fibrillary Acidic Protein; Male; Microglia; Microspheres; Motor Activity; Nerve Fibers; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Serotonin; Sympatholytics; Tyrosine 3-Monooxygenase | 1998 |
Sexual behavior in male rats after radiofrequency or dopamine-depleting lesions in nucleus accumbens.
Topics: Animals; Apomorphine; Central Nervous System Stimulants; Copulation; Dextroamphetamine; Dopamine; Dopamine Agonists; Female; Male; Motor Activity; Nucleus Accumbens; Oxidopamine; Penile Erection; Radiation Injuries, Experimental; Radio Waves; Rats; Sexual Behavior, Animal; Sympatholytics; Yawning | 1998 |
[Behavioral evaluation of the unilateral lesion model in rats using 6-hydroxydopamine. Correlation between the rotations induced by D-amphetamine, apomorphine and the manual dexterity test].
Topics: Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Dextroamphetamine; Dominance, Cerebral; Dopamine; Dose-Response Relationship, Drug; Feeding Behavior; Foot; Forelimb; Male; Motor Activity; Oxidopamine; Parkinson Disease, Secondary; Psychomotor Performance; Rats; Rats, Wistar; Stereotaxic Techniques; Stereotyped Behavior; Substantia Nigra; Sympathectomy, Chemical; Sympatholytics | 1998 |
Circling behaviour in 6-hydroxydopamine-lesioned rats given pulsed levodopa is reduced more by lesions in the entopeduncular nucleus/substantia nigra pars reticulata than in the subthalamic nucleus.
Topics: Adrenergic Agents; Analysis of Variance; Animals; Apomorphine; Benserazide; Corpus Striatum; Dopamine Agents; Dopamine Agonists; Injections, Intraperitoneal; Levodopa; Male; Motor Activity; Oxidopamine; Quinolinic Acid; Rats; Rats, Wistar; Substantia Nigra; Thalamic Nuclei | 1998 |
Apomorphine enantiomers protect cultured pheochromocytoma (PC12) cells from oxidative stress induced by H2O2 and 6-hydroxydopamine.
Topics: Animals; Antiparkinson Agents; Apomorphine; Cell Death; Dose-Response Relationship, Drug; Humans; Hydrogen Peroxide; L-Lactate Dehydrogenase; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Oxidopamine; PC12 Cells; Premedication; Rats; Tumor Cells, Cultured | 1998 |
Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat.
Topics: Amphetamine; Animals; Apomorphine; Corpus Striatum; Dopamine; Female; Forelimb; Microinjections; Motor Activity; Nerve Degeneration; Neurons; Oxidopamine; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Rotation; Substantia Nigra; Tyrosine 3-Monooxygenase | 1998 |
Motor stimulant effects of caffeine in 6-hydroxydopamine-lesioned rats are dependent on previous stimulation of dopamine receptors: a different role of D1 and D2 receptors.
Topics: Animals; Apomorphine; Caffeine; Central Nervous System Stimulants; Dopamine Agonists; Male; Motor Activity; Oxidopamine; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Rotation; Stimulation, Chemical; Triazoles; Xanthines | 1998 |
[Simultaneous transplantation of fetal mesencephalic cells to the striatum and globus pallidus of rats with lesions induced by 6-hydroxydopamine].
Topics: Adrenergic Agents; Animals; Apomorphine; Corpus Striatum; Dopamine Agonists; Fetal Tissue Transplantation; Globus Pallidus; Male; Mesencephalon; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Wistar | 1998 |
[Expression of foreign tyrosine hydroxylase gene in the rat model of Parkinson's disease].
Topics: Animals; Apomorphine; Gene Expression; Genetic Therapy; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Substantia Nigra; Transfection; Tyrosine 3-Monooxygenase | 1997 |
Globus pallidus lesions depress the excitatory responses to apomorphine but not amphetamine in the subthalamic nucleus of the behaving rat with a 6-OHDA nigra lesion.
Topics: Amphetamine; Animals; Apomorphine; Evoked Potentials; Globus Pallidus; Male; Motor Activity; Oxidopamine; Rats; Rotation; Substantia Nigra; Thalamic Nuclei | 1998 |
Effects of bilateral ablation or 6-OHDA lesion of the frontal cortex upon the behaviors induced by apomorphine and amphetamine in adult cats.
Topics: Age Factors; Amphetamine; Animals; Apomorphine; Behavior, Animal; Brain Chemistry; Catecholamines; Cats; Cerebral Decortication; Dopamine; Dopamine Agents; Dopamine Agonists; Fear; Female; Frontal Lobe; Functional Laterality; Locomotion; Male; Oxidopamine; Prefrontal Cortex; Social Behavior; Sympatholytics | 1998 |
The effect of methamphetamine on the release of acetylcholine in the rat striatum.
Topics: Acetylcholine; Adrenergic Agents; Adrenergic Uptake Inhibitors; alpha-Methyltyrosine; Animals; Apomorphine; Corpus Striatum; Dopamine Agonists; Dopamine Uptake Inhibitors; Enzyme Inhibitors; Male; Methamphetamine; Microdialysis; Oxidopamine; Rats; Rats, Wistar; Reserpine; Tetrodotoxin | 1998 |
Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Apomorphine; Behavior, Animal; Benzofurans; Brimonidine Tartrate; Clonidine; Dopamine Agonists; Idazoxan; Imidazoles; Ligands; Male; Methylphenidate; Oxidopamine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Stereoisomerism; Stereotyped Behavior; Substantia Nigra | 1999 |
Intranigral transplants of GABA-rich striatal tissue induce behavioral recovery in the rat Parkinson model and promote the effects obtained by intrastriatal dopaminergic transplants.
Topics: Animals; Apomorphine; Brain Tissue Transplantation; Cell Count; Dopamine; Dopamine Agonists; Female; Fetal Tissue Transplantation; Forelimb; gamma-Aminobutyric Acid; Immunohistochemistry; In Situ Hybridization; Mesencephalon; Motor Activity; Movement; Neostriatum; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Substantia Nigra | 1999 |
Rotational behavior in dopamine nigrostriatal denervated rats: effects of a wide range of time intervals between apomorphine administrations.
Topics: Animals; Apomorphine; Denervation; Dopamine; Dopamine Agonists; Male; Oxidopamine; Rats; Rats, Sprague-Dawley; Rotation; Stereotyped Behavior; Substantia Nigra; Sympatholytics; Time Factors | 1999 |
Kir6.2 oligoantisense administered into the globus pallidus reduces apomorphine-induced turning in 6-OHDA hemiparkinsonian rats.
Topics: Animals; Apomorphine; Globus Pallidus; Male; Motor Activity; Neurons; Oligodeoxyribonucleotides, Antisense; Oxidopamine; Parkinson Disease, Secondary; Peptide Fragments; Rats; Rats, Sprague-Dawley; Rotation | 1999 |
Biochemical and anatomical characterization of forepaw adjusting steps in rat models of Parkinson's disease: studies on medial forebrain bundle and striatal lesions.
Topics: Adaptation, Physiological; Amphetamine; Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Dopamine Agents; Female; Forelimb; Gait; Medial Forebrain Bundle; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Rotation; Substantia Nigra; Sympatholytics; Tyrosine 3-Monooxygenase | 1999 |
Role of serotonergic neurons in L-DOPA-derived extracellular dopamine in the striatum of 6-OHDA-lesioned rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; 5,7-Dihydroxytryptamine; Animals; Apomorphine; Corpus Striatum; Dopamine; Dopamine Agents; Extracellular Space; Levodopa; Male; Microdialysis; Neurons; Oxidopamine; Rats; Rats, Wistar; Rotation; Serotonin; Serotonin Agents; Stereotyped Behavior | 1999 |
Protection and regeneration of nigral dopaminergic neurons by neurturin or GDNF in a partial lesion model of Parkinson's disease after administration into the striatum or the lateral ventricle.
Topics: Amphetamine; Animals; Antibodies; Apomorphine; Atrophy; Body Weight; Cerebral Ventricles; Corpus Striatum; Dopamine; Dopamine Agents; Dopamine Agonists; ELAV Proteins; Female; Glial Cell Line-Derived Neurotrophic Factor; Hydrogen-Ion Concentration; Injections, Intraventricular; Nerve Degeneration; Nerve Growth Factors; Nerve Regeneration; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Neurturin; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; RNA-Binding Proteins; Substantia Nigra; Sympatholytics; Tyrosine 3-Monooxygenase | 1999 |
Compartmental changes in expression of c-Fos and FosB proteins in intact and dopamine-depleted striatum after chronic apomorphine treatment.
Topics: Animals; Apomorphine; Behavior, Animal; Calbindins; Corpus Striatum; Denervation; Dopamine; Dopamine Agonists; Dyskinesia, Drug-Induced; Male; Nerve Tissue Proteins; Neuronal Plasticity; Oxidopamine; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; S100 Calcium Binding Protein G; Sympatholytics | 1999 |
Time dependence and role of N-methyl-D-aspartate glutamate receptors in the priming of D2-mediated rotational behavior and striatal Fos expression in 6-hydroxydopamine lesioned rats.
Topics: Animals; Apomorphine; Behavior, Animal; Brain Chemistry; Corpus Striatum; Dizocilpine Maleate; Dopamine Agonists; Excitatory Amino Acid Antagonists; Male; Nerve Degeneration; Oxidopamine; Piperazines; Proto-Oncogene Proteins c-fos; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Rotation; Sympatholytics; Time Factors | 1999 |
Multiple single-unit recordings in the striatum of freely moving animals: effects of apomorphine and D-amphetamine in normal and unilateral 6-hydroxydopamine-lesioned rats.
Topics: Anesthesia; Anesthetics, Intravenous; Animals; Apomorphine; Brain Diseases; Corpus Striatum; Dextroamphetamine; Dopamine Agents; Dopamine Agonists; Electrophysiology; Injections, Subcutaneous; Male; Neurons; Oxidopamine; Rats; Rats, Inbred F344; Reference Values; Urethane | 1999 |
Rat strain differences in the ability to disrupt sensorimotor gating are limited to the dopaminergic system, specific to prepulse inhibition, and unrelated to changes in startle amplitude or nucleus accumbens dopamine receptor sensitivity.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acoustic Stimulation; Amphetamine; Animals; Apomorphine; Dopamine; Dopamine Agonists; Male; Motor Activity; Nucleus Accumbens; Oxidopamine; Phencyclidine; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Dopamine; Reflex, Startle; Species Specificity; Time Factors | 1999 |
Locomotor-activity-induced changes in striatal levels of preprotachykinin and preproenkephalin mRNA. Regulation by the dopaminergic and glutamatergic systems.
Topics: Animals; Apomorphine; Benzazepines; Corpus Striatum; Denervation; Dizocilpine Maleate; Dopamine; Dopamine Antagonists; Enkephalins; Excitatory Amino Acid Antagonists; Female; Gene Expression Regulation; Glutamic Acid; In Situ Hybridization; Motor Activity; Nerve Tissue Proteins; Oxidopamine; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Running; Tachykinins | 1999 |
Dopamine agonist-mediated rotation in rats with unilateral nigrostriatal lesions is not dependent on net inhibitions of rate in basal ganglia output nuclei.
Topics: Animals; Apomorphine; Basal Ganglia; Behavior, Animal; Corpus Striatum; Dopamine Agonists; Electrophysiology; Hypothalamus; Male; Neural Inhibition; Oxidopamine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Rotation; Stereotypic Movement Disorder; Substantia Nigra; Thalamic Nuclei | 1999 |
Effects of intrasubthalamic injection of dopamine receptor agonists on subthalamic neurons in normal and 6-hydroxydopamine-lesioned rats: an electrophysiological and c-Fos study.
Topics: Adrenergic Agents; Animals; Apomorphine; Benzazepines; Dopamine Agonists; Male; Oxidopamine; Parkinson Disease; Proto-Oncogene Proteins c-fos; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Substantia Nigra; Thalamic Nuclei | 1999 |
Short and long term plasticity after lesioning of the cell body or terminal field area of the dopaminergic mesocorticolimbic system in the rat.
Topics: Adrenocorticotropic Hormone; Animals; Apomorphine; Dopamine; Dose-Response Relationship, Drug; Immunohistochemistry; Male; Motor Activity; Neuronal Plasticity; Neurotransmitter Agents; Nucleus Accumbens; Oxidopamine; Peptide Fragments; Rats; Rats, Wistar; Time Factors; Ventral Tegmental Area | 1999 |
Long-term doxycycline-controlled expression of human tyrosine hydroxylase after direct adenovirus-mediated gene transfer to a rat model of Parkinson's disease.
Topics: Adenoviridae; Animals; Anti-Bacterial Agents; Antiparkinson Agents; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine; Doxycycline; Female; Gene Expression Regulation; Gene Transfer Techniques; Humans; Immunohistochemistry; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine 3-Monooxygenase | 1999 |
Subchronic toluene exposure in low concentrations produces signs of reduced dysfunction in the 6-hydroxydopamine lesioned nigrostriatal dopaminergic system of the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Behavior, Animal; Denervation; Dopamine; Injections, Intraventricular; Male; Motor Activity; Neostriatum; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Substantia Nigra; Toluene; Tyrosine 3-Monooxygenase | 1999 |
Dopamine receptor-modulated [35S]GTPgammaS binding in striatum of 6-hydroxydopamine-lesioned rats.
Topics: Animals; Apomorphine; Benzazepines; Bromocriptine; Cell Membrane; Corpus Striatum; Domperidone; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Ligands; Male; Oxidopamine; Piperazines; Quinpirole; Rats; Rats, Wistar; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Sulfur Radioisotopes; Tritium | 1999 |
Identification of a subpopulation of substantia nigra pars compacta gamma-aminobutyric acid neurons that is regulated by basal ganglia activity.
Topics: Animals; Apomorphine; Basal Ganglia; Corpus Striatum; Dextroamphetamine; Dopamine; Functional Laterality; gamma-Aminobutyric Acid; Gene Expression Regulation; Genes, fos; Glutamate Decarboxylase; Neurons; Oxidopamine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Substantia Nigra; Tyrosine 3-Monooxygenase | 2000 |
Prior D1 dopamine receptor stimulation is required to prime D2-mediated striatal Fos expression in 6-hydroxydopamine-lesioned rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Corpus Striatum; Dopamine; Dopamine Agonists; Gene Expression Regulation; Genes, fos; Male; Motor Activity; Oxidopamine; Proto-Oncogene Proteins c-fos; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Rotation | 1999 |
The effect of a subchronic post-lesion treatment with (-)-deprenyl on the sensitivity of 6-OHDA-lesioned rats to apomorphine and d-amphetamine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Agents; Amphetamine; Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Corpus Striatum; Dopamine; Dopamine Agents; Homovanillic Acid; Male; Medial Forebrain Bundle; Oxidopamine; Rats; Rats, Sprague-Dawley; Selegiline | 1999 |
Evaluation of simple and complex sensorimotor behaviours in rats with a partial lesion of the dopaminergic nigrostriatal system.
Topics: Amphetamine; Animals; Apomorphine; Corpus Striatum; Denervation; Dopamine; Female; Forelimb; Functional Laterality; Gait; Motor Activity; Oxidopamine; Posture; Psychomotor Performance; Rats; Rotation | 2000 |
Autoradiographic study of striatal dopamine re-uptake sites and dopamine D1 and D2 receptors in a 6-hydroxydopamine and quinolinic acid double-lesion rat model of striatonigral degeneration (multiple system atrophy) and effects of embryonic ventral mesenc
Topics: Amphetamine; Animals; Apomorphine; Atrophy; Autoradiography; Behavior, Animal; Brain Tissue Transplantation; Corpus Striatum; Dopamine; Dopamine Agonists; Dopamine Uptake Inhibitors; Fetal Tissue Transplantation; Male; Mazindol; Nerve Degeneration; Neurons; Oxidopamine; Quinolinic Acid; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Rotation; Substantia Nigra; Sympatholytics; Tritium | 2000 |
The pivotal role of iron in NF-kappa B activation and nigrostriatal dopaminergic neurodegeneration. Prospects for neuroprotection in Parkinson's disease with iron chelators.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Adrenergic Agents; Animals; Antiparkinson Agents; Apomorphine; Corpus Striatum; Dopamine; Dopamine Agents; Ferritins; Iron; Lipid Peroxidation; Mice; Nerve Degeneration; NF-kappa B; Oxidopamine; Parkinsonian Disorders; PC12 Cells; Rats; Tyrosine 3-Monooxygenase | 1999 |
Does dopamine contribute to striatal damage caused by impaired mitochondrial function?
Topics: Animals; Apomorphine; Biological Transport; Clorgyline; Corpus Striatum; Dopamine; Malonates; Medial Forebrain Bundle; Mitochondria; Monoamine Oxidase Inhibitors; Nitro Compounds; Oxidopamine; Propionates; Rats; Selegiline; Substantia Nigra | 1999 |
Effect of acute L-Dopa pretreatment on apomorphine-induced rotational behavior in a rat model of Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Carbidopa; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Levodopa; Male; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Inbred F344; Rotation; Substantia Nigra; Sympatholytics | 2000 |
Motor effects of (-)-OSU6162 in primates with unilateral 6-hydroxydopamine lesions.
Topics: Adamantane; Animals; Apomorphine; Benzazepines; Benzopyrans; Callithrix; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; Levodopa; Male; Motor Activity; Oxidopamine; Parkinson Disease; Piperidines; Quinpirole; Rotation | 2000 |
Detection of the effects of dopamine receptor supersensitivity using pharmacological MRI and correlations with PET.
Topics: Amphetamine; Animals; Apomorphine; Cerebrovascular Circulation; Cocaine; Dopamine Agonists; Dopamine Uptake Inhibitors; Hemodynamics; Magnetic Resonance Imaging; Male; Neostriatum; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Dopamine D2; Rotation; Stereotyped Behavior; Sympathectomy, Chemical; Sympatholytics; Tomography, Emission-Computed | 2000 |
Haloperidol reverses the changes in striatal glutamatergic immunolabeling following a 6-OHDA lesion.
Topics: Animals; Apomorphine; Denervation; Dopamine Agonists; Dopamine Antagonists; Glutamic Acid; Haloperidol; Immunohistochemistry; Male; Motor Cortex; Neostriatum; Nerve Degeneration; Neural Pathways; Oxidopamine; Parkinsonian Disorders; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Time Factors | 2000 |
The effect of intrastriatal single injection of GDNF on the nigrostriatal dopaminergic system in hemiparkinsonian rats: behavioral and histological studies using two different dosages.
Topics: Animals; Apomorphine; Axons; Behavior, Animal; Disease Models, Animal; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Female; Functional Laterality; Glial Cell Line-Derived Neurotrophic Factor; Immunohistochemistry; Movement; Neostriatum; Nerve Degeneration; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Rotation; Substantia Nigra; Sympatholytics; Time Factors; Tyrosine 3-Monooxygenase; Weight Loss | 2000 |
Multi-site partitioned delivery of human tyrosine hydroxylase gene with phenotypic recovery in Parkinsonian rats.
Topics: Adenoviridae; Adrenergic Agents; Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Cell Count; Corpus Striatum; Disease Models, Animal; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Humans; Male; Motor Activity; Oxidopamine; Parkinson Disease, Secondary; Phenotype; Rats; Rats, Inbred F344; Recovery of Function; Treatment Outcome; Tyrosine 3-Monooxygenase | 2000 |
Effects of oligonucleotide antisense to dopamine D(1A) receptor messenger RNA in a rodent model of levodopa-induced dyskinesia.
Topics: Animals; Antiparkinson Agents; Apomorphine; Autoradiography; Behavior, Animal; Cocaine; Denervation; Disease Models, Animal; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dyskinesia, Drug-Induced; Gene Expression; Levodopa; Male; Oligonucleotides, Antisense; Oxidopamine; Phenotype; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; RNA, Messenger; Rotation; Substantia Nigra; Sympatholytics; Tritium | 2000 |
Lentiviral vectors as a gene delivery system in the mouse midbrain: cellular and behavioral improvements in a 6-OHDA model of Parkinson's disease using GDNF.
Topics: Animals; Apomorphine; Cell Count; Corpus Striatum; Dopamine; Genes, Reporter; Genetic Therapy; Genetic Vectors; Glial Cell Line-Derived Neurotrophic Factor; Lentivirus; Male; Mesencephalon; Mice; Mice, Inbred C57BL; Microinjections; Motor Activity; Nerve Growth Factors; Nerve Tissue Proteins; Oxidopamine; Parkinson Disease, Secondary; Substantia Nigra; Tyrosine 3-Monooxygenase | 2000 |
Fetal ventral mesencephalic grafts functionally reduce the dopamine D2 receptor supersensitivity in partially dopamine reinnervated host striatum.
Topics: Animals; Apomorphine; Benzazepines; Brain Tissue Transplantation; Corpus Striatum; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Female; Fetal Tissue Transplantation; Glutamic Acid; Membrane Potentials; Mesencephalon; Microdialysis; Microelectrodes; Motor Activity; Oxidopamine; Parkinson Disease, Secondary; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Tyrosine 3-Monooxygenase | 2000 |
Failure of neuroprotection by embryonic striatal grafts in a double lesion rat model of striatonigral degeneration (multiple system atrophy).
Topics: Animals; Apomorphine; Autoradiography; Binding, Competitive; Brain Tissue Transplantation; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agonists; Dopamine Plasma Membrane Transport Proteins; Fetal Tissue Transplantation; Male; Membrane Proteins; Motor Activity; Multiple System Atrophy; Nerve Tissue Proteins; Oxidopamine; Quinolinic Acid; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Striatonigral Degeneration; Treatment Failure | 2000 |
Dopamine transporter function assessed by antisense knockdown in the rat: protection from dopamine neurotoxicity.
Topics: 1-Methyl-4-phenylpyridinium; Amphetamine; Animals; Apomorphine; Autoradiography; Carrier Proteins; Cocaine; Corpus Striatum; Cytoprotection; Dopamine Plasma Membrane Transport Proteins; Levodopa; Male; Membrane Glycoproteins; Membrane Transport Proteins; Microinjections; Motor Activity; Nerve Tissue Proteins; Oligonucleotides, Antisense; Oxidopamine; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substantia Nigra; Tritium | 2000 |
Increased behavioral response to dopaminergic stimulation of the subthalamic nucleus after nigrostriatal lesions.
Topics: Adamantane; Animals; Apomorphine; Autoradiography; Behavior, Animal; Benzazepines; Benzopyrans; Corpus Striatum; Denervation; Dopamine; Dopamine Agonists; Dopamine Antagonists; Male; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Substantia Nigra; Subthalamic Nucleus; Sympatholytics | 2000 |
Synaptic integration mediated by striatal cholinergic interneurons in basal ganglia function.
Topics: Acetylcholine; Animals; Apomorphine; Basal Ganglia; Choline O-Acetyltransferase; Corpus Striatum; Dopamine; Dopamine Agonists; Down-Regulation; Enkephalins; Immunotoxins; Interneurons; Mice; Mice, Transgenic; Motor Activity; Oxidopamine; Posture; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Glutamate; Substance P; Synapses | 2000 |
Influence of environment on the efficacy of intrastriatal dopaminergic grafts.
Topics: Animals; Apomorphine; Behavior, Animal; Brain; Corpus Striatum; Dextroamphetamine; Dopamine; Environment; Fetal Tissue Transplantation; Graft Survival; Injections; Male; Mesencephalon; Oxidopamine; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Tyrosine 3-Monooxygenase | 2000 |
Environmental modulation of the response to amphetamine: dissociation between changes in behavior and changes in dopamine and glutamate overflow in the rat striatal complex.
Topics: Amphetamine; Animals; Apomorphine; Aspartic Acid; Behavior, Animal; Central Nervous System Stimulants; Dopamine; Dopamine Agonists; Dopamine Uptake Inhibitors; Environment; Glutamic Acid; Male; Microdialysis; Neostriatum; Oxidopamine; Rats; Rats, Sprague-Dawley; Sympathectomy, Chemical; Sympatholytics | 2000 |
Effects of the prototypical mGlu(5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine on rotarod, locomotor activity and rotational responses in unilateral 6-OHDA-lesioned rats.
Topics: Animals; Apomorphine; Dextroamphetamine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Levodopa; Male; Motor Activity; Oxidopamine; Pyridines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Rotation | 2000 |
Preservation of a functional nigrostriatal dopamine pathway by GDNF in the intrastriatal 6-OHDA lesion model depends on the site of administration of the trophic factor.
Topics: Animals; Apomorphine; Cerebral Ventricles; Corpus Striatum; Dopamine; Female; Functional Laterality; Glial Cell Line-Derived Neurotrophic Factor; Injections, Intraventricular; Microinjections; Motor Activity; Nerve Fibers; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Oxidopamine; Rats; Rats, Sprague-Dawley; Substantia Nigra; Tyrosine 3-Monooxygenase | 2000 |
Effects of repeated methyl levodopa administration on apomorphine sensitivity of rotational behavior and striatal Fos expression of rats with unilateral 6-OHDA lesions.
Topics: Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Caudate Nucleus; Corpus Striatum; Dopamine; Drug Resistance; Globus Pallidus; Levodopa; Male; Oxidopamine; Proto-Oncogene Proteins c-fos; Putamen; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Substantia Nigra | 2000 |
Adenosine A(2A) receptor antagonists KF17837 and KW-6002 potentiate rotation induced by dopaminergic drugs in hemi-Parkinsonian rats.
Topics: Animals; Apomorphine; Behavior, Animal; Dopamine Agents; Dose-Response Relationship, Drug; Drug Synergism; Levodopa; Male; Oxidopamine; Parkinson Disease, Secondary; Purinergic P1 Receptor Antagonists; Purines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Xanthines | 2000 |
Melatonin protects against 6-OHDA-induced neurotoxicity in rats: a role for mitochondrial complex I activity.
Topics: Adenosine Triphosphatases; Animals; Apomorphine; Behavior, Animal; Disease Models, Animal; Electron Transport Complex IV; Electrophoresis, Polyacrylamide Gel; Male; Melatonin; Mitochondria; Motor Activity; NAD; Neuroprotective Agents; Oxidative Phosphorylation; Oxidopamine; Parkinson Disease; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Substantia Nigra | 2001 |
Environmental novelty differentially affects c-fos mRNA expression induced by amphetamine or cocaine in subregions of the bed nucleus of the stria terminalis and amygdala.
Topics: Amphetamine; Amygdala; Animals; Apomorphine; Behavior, Animal; Cocaine; Corpus Striatum; Environment; In Situ Hybridization; Male; Microinjections; Motor Activity; Oxidopamine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA, Messenger; Septal Nuclei | 2001 |
Intranigral transplantation of solid tissue ventral mesencephalon or striatal grafts induces behavioral recovery in 6-OHDA-lesioned rats.
Topics: Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Brain Tissue Transplantation; Corpus Striatum; Male; Nerve Degeneration; Neurons; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Inbred F344; Recovery of Function; Substantia Nigra; Sympatholytics; Tyrosine 3-Monooxygenase | 2001 |
IGF-I and bFGF improve dopamine neuron survival and behavioral outcome in parkinsonian rats receiving cultured human fetal tissue strands.
Topics: Abortion, Induced; Animals; Apomorphine; Brain; Brain Tissue Transplantation; Cell Survival; Cells, Cultured; Disease Models, Animal; Dopamine; Female; Fetal Tissue Transplantation; Fibroblast Growth Factor 2; Homovanillic Acid; Humans; Insulin-Like Growth Factor I; Male; Methamphetamine; Motor Activity; Neurons; Oxidopamine; Parkinsonian Disorders; Pregnancy; Rats; Rats, Sprague-Dawley; Rotation; Transplantation, Heterologous; Tyrosine 3-Monooxygenase | 2001 |
Neuroprotective effect of vitamin E on the early model of Parkinson's disease in rat: behavioral and histochemical evidence.
Topics: Amphetamine; Animals; Apomorphine; Atrophy; Axonal Transport; Corpus Striatum; Disease Models, Animal; Male; Motor Activity; Neurons; Neuroprotective Agents; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Rotation; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase; Vitamin E; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate | 2001 |
Intrasubthalamic injection of 6-hydroxydopamine induces changes in the firing rate and pattern of subthalamic nucleus neurons in the rat.
Topics: Action Potentials; Animals; Apomorphine; Dopamine; Dopamine Agonists; Male; Motor Activity; Neural Pathways; Neurons; Neurotoxins; Oxidopamine; Rats; Rats, Wistar; Substantia Nigra; Subthalamic Nucleus; Sympatholytics | 2001 |
Action sites of rotation and unit firing induced by l-stepholidine and DA agonists in basal ganglia of 6-OHDA-lesioned rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Berberine; Dopamine Agonists; Dopamine Antagonists; Electrophysiology; Male; Neostriatum; Oxidopamine; Rats; Rats, Sprague-Dawley; Rotation; Substantia Nigra | 1999 |
NMDA glutamate receptor stimulation is required for the expression of D2 dopamine mediated responses in apomorphine primed 6-hydroxydopamine lesioned rats.
Topics: Animals; Apomorphine; Behavior, Animal; Brain Chemistry; Denervation; Dizocilpine Maleate; Dopamine Agonists; Excitatory Amino Acid Antagonists; Male; Oxidopamine; Parkinson Disease; Piperazines; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Sympatholytics | 2001 |
Entopeduncular lesions facilitate and thalamic lesions depress spontaneous and drug-evoked motor behavior in the hemiparkinsonian rat.
Topics: Amphetamine; Animals; Apomorphine; Denervation; Disease Models, Animal; Dopamine Agonists; Dyskinesia, Drug-Induced; Entopeduncular Nucleus; Male; Motor Cortex; Neural Inhibition; Neural Pathways; Neurosurgical Procedures; Oxidopamine; Parkinsonian Disorders; Rats; Thalamus; Ventral Thalamic Nuclei | 2001 |
Intrapallidal dopamine restores motor deficits induced by 6-hydroxydopamine in the rat.
Topics: Animals; Apomorphine; Benzazepines; Dopamine; Dopamine Agonists; Dopamine Antagonists; gamma-Aminobutyric Acid; Globus Pallidus; Male; Motor Activity; Nerve Degeneration; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Recovery of Function; Sulpiride; Sympatholytics | 2001 |
Forced limb-use effects on the behavioral and neurochemical effects of 6-hydroxydopamine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Behavior, Animal; Body Temperature; Casts, Surgical; Corpus Striatum; Disease Models, Animal; Dopamine; Forelimb; Homovanillic Acid; Immobilization; Male; Medial Forebrain Bundle; Membrane Glycoproteins; Membrane Transport Proteins; Microinjections; Neural Pathways; Neurons; Neuropeptides; Oxidopamine; Parkinson Disease; Parkinson Disease, Secondary; Rats; Rats, Long-Evans; Substantia Nigra; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2001 |
Effect of olanzapine on functional responses from sensitized D1-dopamine receptors in rats with neonatal dopamine loss.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adrenergic Agents; Animals; Animals, Newborn; Antipsychotic Agents; Apomorphine; Benzodiazepines; Corpus Striatum; Dopamine; Dopamine Agonists; Female; Male; Motor Activity; Olanzapine; Oxidopamine; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1 | 2001 |
In vivo extracellular recording of striatal neurons in the awake rat following unilateral 6-hydroxydopamine lesions.
Topics: Action Potentials; Anesthesia; Animals; Apomorphine; Chloral Hydrate; Corpus Striatum; Disease Models, Animal; Dopamine; Electrodes, Implanted; Male; Microelectrodes; Motor Activity; Neurons; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Inbred F344; Receptors, Dopamine D2; Wakefulness | 2001 |
Differential effects of unilateral striatal and nigrostriatal lesions on grip strength, skilled paw reaching and drug-induced rotation in the rat.
Topics: Amphetamine; Animals; Apomorphine; Central Nervous System Stimulants; Corpus Striatum; Denervation; Dopamine Agonists; Female; Functional Laterality; Hand Strength; Motor Activity; Oxidopamine; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Rotation; Substantia Nigra; Sympatholytics | 2001 |
Effect of microiontophoretic application of dopamine on subthalamic nucleus neuronal activity in normal rats and in rats with unilateral lesion of the nigrostriatal pathway.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Action Potentials; Animals; Apomorphine; Dopamine; Dopamine Agonists; Drug Interactions; gamma-Aminobutyric Acid; Glutamic Acid; Iontophoresis; Male; Neostriatum; Neural Pathways; Neurons; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Receptors, Dopamine D1; Substantia Nigra; Subthalamic Nucleus; Sympatholytics | 2001 |
Functional effect of adeno-associated virus mediated gene transfer of aromatic L-amino acid decarboxylase into the striatum of 6-OHDA-lesioned rats.
Topics: Animals; Apomorphine; Aromatic-L-Amino-Acid Decarboxylases; Dependovirus; Disease Models, Animal; Dopamine; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Levodopa; Neostriatum; Oxidopamine; Parkinson Disease; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Rotation; Transduction, Genetic | 2001 |
Increased burst firing in substantia nigra pars reticulata neurons and enhanced response to selective D2 agonist in hemiparkinsonian rats after repeated administration of apomorphine.
Topics: Animals; Apomorphine; Dopamine Agonists; Male; MPTP Poisoning; Oxidopamine; Parkinsonian Disorders; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Substantia Nigra | 2001 |
Up-regulation of secretoneurin immunoreactivity and secretogranin II mRNA in rat striatum following 6-hydroxydopamine lesioning and chronic L-DOPA treatment.
Topics: Animals; Apomorphine; Chromogranins; DNA, Complementary; Dopamine Agonists; Drug Administration Schedule; Gene Expression Regulation; Immunohistochemistry; In Situ Hybridization; Levodopa; Male; Neostriatum; Neurons; Neuropeptides; Oxidopamine; Parkinsonian Disorders; Proteins; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Secretogranin II; Sympatholytics; Up-Regulation | 2001 |
Antiparkinson-like effects of a novel neurotensin analog in unilaterally 6-hydroxydopamine lesioned rats.
Topics: Amphetamine; Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Corpus Striatum; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Motor Activity; Neurotensin; Oxidopamine; Parkinson Disease, Secondary; Peptide Fragments; Rats; Rats, Sprague-Dawley | 2001 |
Intrastriatal injection of sonic hedgehog reduces behavioral impairment in a rat model of Parkinson's disease.
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Glial Cell Line-Derived Neurotrophic Factor; Hedgehog Proteins; Humans; Microinjections; Motor Activity; Myristic Acid; Nerve Growth Factors; Nerve Tissue Proteins; Organ Specificity; Oxidopamine; Parkinson Disease, Secondary; Peptide Fragments; Rats; Trans-Activators; Tyrosine 3-Monooxygenase | 2002 |
Differential effects of a small, unilateral, 6-hydroxydopamine-induced nigral lesion on behavior in high and low responders to novelty.
Topics: Animals; Apomorphine; Behavior, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Male; Microinjections; Motor Activity; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Wistar; Spatial Behavior; Substantia Nigra; Tyrosine 3-Monooxygenase | 2002 |
Effects of short- and long-acting dopamine agonists on sensitized dopaminergic neurotransmission in rats with unilateral 6-OHDA lesions.
Topics: Adrenergic Agents; Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Cabergoline; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Drug Antagonism; Ergolines; Levodopa; Male; Oxidopamine; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Synaptic Transmission | 2002 |
Erectile dysfunction occurs following substantia nigra lesions in the rat.
Topics: Animals; Apomorphine; Behavior, Animal; Brain Diseases; Corpus Striatum; Dopamine; Dopamine Agonists; Electric Stimulation; Erectile Dysfunction; Male; Nervous System; Oxidopamine; Penile Erection; Penis; Pressure; Rats; Rats, Sprague-Dawley; Substantia Nigra | 2001 |
The rate of intravenous cocaine administration determines susceptibility to sensitization.
Topics: Animals; Apomorphine; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship, Drug; Drug Tolerance; Injections, Intravenous; Male; Medial Forebrain Bundle; Microinjections; Motor Activity; Oxidopamine; Rats; Rats, Sprague-Dawley; Time Factors | 2002 |
Drug-induced rotation intensity in unilateral dopamine-depleted rats is not correlated with end point or qualitative measures of forelimb or hindlimb motor performance.
Topics: Amphetamine; Animals; Apomorphine; Corpus Striatum; Dopamine; Dopamine Agents; Dopamine Agonists; Female; Forelimb; Hindlimb; Levodopa; Motor Activity; Motor Skills; Oxidopamine; Psychomotor Performance; Rats; Rats, Long-Evans; Rotation; Stereotyped Behavior; Substantia Nigra | 2002 |
Nicotine alters striatal glutamate function and decreases the apomorphine-induced contralateral rotations in 6-OHDA-lesioned rats.
Topics: Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Corpus Striatum; Drug Administration Schedule; Drug Antagonism; Extracellular Space; Glutamic Acid; Immunohistochemistry; Male; Microdialysis; Microscopy, Electron; Motor Activity; Nicotine; Nicotinic Agonists; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Synapses | 2002 |
Somatostatin modulates the behavioral effects of dopamine receptor activation in parkinsonian rats.
Topics: Animals; Apomorphine; Autoradiography; Behavior, Animal; Binding, Competitive; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Drug Administration Routes; Male; Medial Forebrain Bundle; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Somatostatin | 2002 |
Nucleus accumbens dopamine and discriminated approach learning: interactive effects of 6-hydroxydopamine lesions and systemic apomorphine administration.
Topics: Animals; Apomorphine; Discrimination Learning; Dopamine; Drug Interactions; Male; Nucleus Accumbens; Oxidopamine; Rats | 2002 |
Striatal xenotransplantation of human retinal pigment epithelial cells attached to microcarriers in hemiparkinsonian rats ameliorates behavioral deficits without provoking a host immune response.
Topics: Animals; Apomorphine; Behavior, Animal; Cell Transplantation; Corpus Striatum; Dextrans; Dopamine; Fetal Tissue Transplantation; Graft Rejection; Humans; Male; Microspheres; Motor Activity; Neurons; Oxidopamine; Parkinsonian Disorders; Pigment Epithelium of Eye; Random Allocation; Rats; Rats, Sprague-Dawley; Rotation; Transplantation, Heterologous | 2002 |
Adeno-associated viral delivery of GDNF promotes recovery of dopaminergic phenotype following a unilateral 6-hydroxydopamine lesion.
Topics: Animals; Apomorphine; Behavior, Animal; Cell Line; Corpus Striatum; Dependovirus; Disease Models, Animal; Dopamine; Genetic Therapy; Glial Cell Line-Derived Neurotrophic Factor; Humans; Male; Medial Forebrain Bundle; Motor Activity; Nerve Growth Factors; Oxidopamine; Parkinsonian Disorders; Phenotype; Rats; Rats, Inbred F344; Substantia Nigra; Tyrosine 3-Monooxygenase | 2002 |
Partial loss of dopaminergic neurons in the substantia nigra, ventrotegmental area and the retrorubral area -- model of the early beginning of Parkinson's symptomatology?
Topics: Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Dopamine; Dopamine Agonists; Male; Maze Learning; Motor Activity; Neurons; Oxidopamine; Parkinson Disease; Parkinson Disease, Secondary; Rats; Rats, Wistar; Red Nucleus; Substantia Nigra; Swimming; Tegmentum Mesencephali | 2002 |
Efficacy of elevated body swing test in the early model of Parkinson's disease in rat.
Topics: Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Male; Neostriatum; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Rotation; Stereotyped Behavior; Substantia Nigra; Sympatholytics | 2002 |
Forced nonuse in unilateral parkinsonian rats exacerbates injury.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Behavior, Animal; Brain Chemistry; Casts, Surgical; Corpus Striatum; Disease Models, Animal; Disease Progression; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Forelimb; Homovanillic Acid; Membrane Glycoproteins; Membrane Transport Proteins; Movement; Nerve Tissue Proteins; Neuropeptides; Oxidopamine; Parkinsonian Disorders; Physical Exertion; Rats; Rats, Long-Evans; Restraint, Physical; Tyrosine 3-Monooxygenase; Vesicular Biogenic Amine Transport Proteins | 2002 |
Compromised peripheral immunity of mice injected intrastriatally with six-hydroxydopamine.
Topics: Animals; Apomorphine; Body Weight; Corpus Striatum; Corticosterone; Dopamine; Hemocyanins; Hypersensitivity, Delayed; Immunity; Interferon-gamma; Listeriosis; Male; Mice; Mice, Inbred BALB C; Norepinephrine; Oxidopamine | 2002 |
Comparison of the efficacy of cell preparations from embryonic ventral mesencephalon of various prenatal age transplanted intrastriatally to rats with 6-OHDA-induced Parkinsonism.
Topics: Animals; Apomorphine; Brain Tissue Transplantation; Dopamine; Fetal Tissue Transplantation; Male; Mesencephalon; Motor Activity; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar | 2002 |
A novel skilled-reaching impairment in paw supination on the "good" side of the hemi-Parkinson rat improved with rehabilitation.
Topics: Animals; Apomorphine; Behavior Control; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Feeding Behavior; Female; Forelimb; Functional Laterality; Motor Skills; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Long-Evans; Recovery of Function; Substantia Nigra; Supination | 2003 |
Relationships between various behavioural abnormalities and nigrostriatal dopamine depletion in the unilateral 6-OHDA-lesioned rat.
Topics: Animals; Apomorphine; Behavior, Animal; Cell Death; Disease Models, Animal; Dopamine; Female; Functional Laterality; Neostriatum; Neurons; Orientation; Oxidopamine; Parkinsonian Disorders; Perceptual Disorders; Postural Balance; Posture; Rats; Rats, Sprague-Dawley; Substantia Nigra | 2003 |
Acupuncture prevents 6-hydroxydopamine-induced neuronal death in the nigrostriatal dopaminergic system in the rat Parkinson's disease model.
Topics: Acupuncture Therapy; Animals; Apomorphine; Behavior, Animal; Cell Count; Cell Survival; Corpus Striatum; Disease Models, Animal; Dopamine; Immunohistochemistry; Male; Motor Activity; Neurons; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Receptor, trkB; Substantia Nigra; Tyrosine 3-Monooxygenase | 2003 |
Neuroprotective effects of prior limb use in 6-hydroxydopamine-treated rats: possible role of GDNF.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Behavior, Animal; Casts, Surgical; Corpus Striatum; Disease Models, Animal; Dopamine; Forelimb; Functional Laterality; Glial Cell Line-Derived Neurotrophic Factor; Immobilization; Male; Medial Forebrain Bundle; Motor Activity; Nerve Growth Factors; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Long-Evans; Rats, Sprague-Dawley | 2003 |
EEG modifications in the cortex and striatum after dopaminergic priming in the 6-hydroxydopamine rat model of Parkinson's disease.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adrenergic Agents; Animals; Apomorphine; Behavior, Animal; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Dizocilpine Maleate; Dopamine Agonists; Drug Interactions; Electroencephalography; Excitatory Amino Acid Antagonists; Male; Medial Forebrain Bundle; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley | 2003 |
Convulsive and postural effects of lesioning the mid-substantia nigra pars reticulata in naïve and 6-hydroxydopamine lesioned rats.
Topics: Animals; Apomorphine; Behavior, Animal; Cortical Synchronization; Disease Models, Animal; Dopamine Agonists; Female; Functional Laterality; Kainic Acid; Motor Activity; Oxidopamine; Parkinsonian Disorders; Perceptual Disorders; Posture; Rats; Rats, Sprague-Dawley; Rotation; Seizures; Substantia Nigra | 2003 |
Is the Ecstasy-induced ipsilateral rotation in 6-hydroxydopamine unilaterally lesioned rats dopamine independent?
Topics: 3,4-Methylenedioxyamphetamine; Adrenergic Agents; Animals; Apomorphine; Behavior, Animal; Citalopram; Dopamine; Fenclonine; Functional Laterality; Hallucinogens; Male; Medial Forebrain Bundle; Models, Animal; N-Methyl-3,4-methylenedioxyamphetamine; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotation; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists | 2003 |
Riluzole, an inhibitor of glutamatergic transmission, suppresses levodopa-induced rotations in 6-hydroxydopamine-lesioned rats.
Topics: Animals; Antiparkinson Agents; Apomorphine; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Levodopa; Male; Motor Activity; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Riluzole; Synaptic Transmission | 2003 |
Dopamine depletion abolishes apomorphine- and amphetamine-induced increases in extracellular serotonin levels in the striatum of conscious rats: a microdialysis study.
Topics: Afferent Pathways; Amphetamine; Animals; Apomorphine; Binding, Competitive; Carrier Proteins; Denervation; Disease Models, Animal; Dopamine; Dopamine Agonists; Extracellular Matrix; Membrane Glycoproteins; Membrane Transport Proteins; Microdialysis; Neostriatum; Nerve Tissue Proteins; Neuronal Plasticity; Oxidopamine; Parkinsonian Disorders; Paroxetine; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Plasma Membrane Transport Proteins; Synaptic Transmission | 2003 |
The CB1 cannabinoid receptor agonist, HU-210, reduces levodopa-induced rotations in 6-hydroxydopamine-lesioned rats.
Topics: Animals; Apomorphine; Cannabinoids; Carbidopa; Cell Line, Tumor; Dronabinol; Levodopa; Male; Motor Activity; Neuroprotective Agents; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rotation; Substantia Nigra | 2003 |
In vivo delivery of glial cell-derived neurotrophic factor across the blood-brain barrier by gene transfer into brain capillary endothelial cells.
Topics: Animals; Apomorphine; Behavior, Animal; Blood-Brain Barrier; Blotting, Western; Brain; Brain-Derived Neurotrophic Factor; Capillaries; Carotid Artery, Internal; Cell Culture Techniques; Dopamine; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Liposomes; Mice; Neuroglia; Oxidopamine; Plasmids; Sendai virus; Transfection | 2003 |
High frequency stimulation of the subthalamic nucleus improves treadmill locomotion in unilateral 6-hydroxydopamine lesioned rats.
Topics: Animals; Apomorphine; Basal Ganglia; Dopamine Agonists; Electric Stimulation; Electrodes, Implanted; Immunohistochemistry; Male; Motor Activity; Oxidopamine; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Subthalamic Nucleus; Sympathectomy, Chemical; Sympatholytics | 2003 |
High frequency stimulation of the subthalamic nucleus has beneficial antiparkinsonian effects on motor functions in rats, but less efficiency in a choice reaction time task.
Topics: Adrenergic Agents; Animals; Anti-Dyskinesia Agents; Antiparkinson Agents; Apomorphine; Catalepsy; Choice Behavior; Cognition; Conditioning, Operant; Electric Stimulation Therapy; Functional Laterality; Haloperidol; Male; Models, Animal; Motor Activity; Oxidopamine; Parkinson Disease; Rats; Rats, Long-Evans; Reaction Time; Subthalamic Nucleus | 2003 |
Treatment effects on nigrostriatal projection integrity in partial 6-OHDA lesions: comparison of L-DOPA and pramipexole.
Topics: Amphetamine; Animals; Antiparkinson Agents; Apomorphine; Autoradiography; Behavior, Animal; Benzothiazoles; Binding, Competitive; Corpus Striatum; Disease Models, Animal; Levodopa; Male; Membrane Glycoproteins; Membrane Transport Proteins; Motor Activity; Neuropeptides; Oxidopamine; Parkinsonian Disorders; Pramipexole; Rats; Rats, Sprague-Dawley; Substantia Nigra; Thiazoles; Treatment Outcome; Tritium; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2003 |
Dopaminergic trophism after intrastriatal injection of lentivirus-transferred GDNF in Parkinson rat model.
Topics: Animals; Apomorphine; Behavior, Animal; Cell Line; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Genetic Vectors; Glial Cell Line-Derived Neurotrophic Factor; Humans; Immunohistochemistry; Lentivirus; Male; Nerve Growth Factors; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Tyrosine 3-Monooxygenase | 2003 |
Apomorphine attenuates 6-hydroxydopamine-induced apoptotic cell death in SH-SY5Y cells.
Topics: Antiparkinson Agents; Apomorphine; Apoptosis; Cell Line, Tumor; DNA Fragmentation; Glutathione; Humans; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Reactive Oxygen Species; Sympatholytics | 2003 |
"Hydrocephalus-parkinsonism complex": progressive hydrocephalus as a factor affecting extrapyramidal tract disorder-an experimental study.
Topics: Animals; Antiparkinson Agents; Apomorphine; Basal Ganglia Diseases; Behavior, Animal; Disease Models, Animal; Drug Interactions; Functional Laterality; Hydrocephalus; Kaolin; Male; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Rotation; Substantia Nigra; Time Factors | 2004 |
Uptake of 6-[18F]fluoro-L-dopa and [18F]CFT reflect nigral neuronal loss in a rat model of Parkinson's disease.
Topics: Amphetamine; Animals; Apomorphine; Autoradiography; Behavior, Animal; Brain; Brain Mapping; Central Nervous System Stimulants; Dihydroxyphenylalanine; Disease Models, Animal; Dopamine Agonists; Functional Laterality; Immunohistochemistry; Levodopa; Male; Oxidopamine; Parkinson Disease; Propionates; Radioligand Assay; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Substantia Nigra; Sympatholytics; Tyrosine 3-Monooxygenase | 2004 |
A2A antagonist prevents dopamine agonist-induced motor complications in animal models of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Apomorphine; Denervation; Dopamine Agonists; Dyskinesia, Drug-Induced; Levodopa; Macaca fascicularis; Male; Neurons; Oxidopamine; Parkinson Disease, Secondary; Phosphorylation; Purines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Dopamine D1; Receptors, Dopamine D2; Sympatholytics | 2003 |
Effects of electrolytic and 6-hydroxydopamine lesions of rat nigrostriatal pathway on nitric oxide synthase and nicotinamide adenine dinucleotide phosphate diaphorase.
Topics: Adrenergic Agents; Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Electric Injuries; Functional Laterality; Immunohistochemistry; Injections, Intraventricular; Male; Microelectrodes; NADPH Dehydrogenase; Nitric Oxide Synthase; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar | 2003 |
Lesion of subthalamic or motor thalamic nucleus in 6-hydroxydopamine-treated rats: effects on striatal glutamate and apomorphine-induced contralateral rotations.
Topics: Animals; Apomorphine; Corpus Striatum; Glutamic Acid; Male; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Subthalamic Nucleus | 2004 |
Upregulation of striatal adenosine A2A receptor mRNA in 6-hydroxydopamine-lesioned rats intermittently treated with L-DOPA.
Topics: Animals; Apomorphine; Autoradiography; Dopamine Agents; Dopamine Agonists; Levodopa; Male; Neostriatum; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Wistar; Receptor, Adenosine A2A; RNA, Messenger; Stereotyped Behavior; Sympathectomy, Chemical; Sympatholytics; Up-Regulation | 2004 |
Antiparkinsonian activity of Ro 25-6981, a NR2B subunit specific NMDA receptor antagonist, in animal models of Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Apomorphine; Callithrix; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Synergism; Levodopa; Male; Motor Activity; Oxidopamine; Parkinsonian Disorders; Phenols; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2004 |
Pituitary adenylate cyclase activating polypeptide protects dopaminergic neurons and improves behavioral deficits in a rat model of Parkinson's disease.
Topics: Adrenergic Agents; Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Behavioral Symptoms; Disease Models, Animal; Dopamine; Dopamine Agonists; Drug Interactions; Immunohistochemistry; Male; Motor Activity; Neurons; Neuropeptides; Oxidopamine; Parkinson Disease; Pituitary Adenylate Cyclase-Activating Polypeptide; Rats; Rats, Wistar; Rotation; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase | 2004 |
Voluntary running provides neuroprotection in rats after 6-hydroxydopamine injection into the medial forebrain bundle.
Topics: Animals; Antiparkinson Agents; Apomorphine; Corpus Striatum; Dopamine; Male; Medial Forebrain Bundle; Motor Activity; Oxidopamine; Parkinsonian Disorders; Physical Conditioning, Animal; Rats; Rats, Long-Evans; Running; Substantia Nigra; Sympathectomy, Chemical; Sympatholytics | 2004 |
Evaluation of functional asymmetry in rats with dose-dependent lesions of dopaminergic nigrostriatal system using elevated body swing test.
Topics: Analysis of Variance; Animals; Apomorphine; Dopamine Agents; Dose-Response Relationship, Drug; Functional Laterality; Male; Microinjections; Motor Skills; Movement; Neostriatum; Oxidopamine; Posture; Random Allocation; Rats; Rats, Wistar; Reproducibility of Results; Single-Blind Method; Substantia Nigra | 2004 |
Intranigral injection of the H3 agonist immepip and systemic apomorphine elicit ipsilateral turning behaviour in naive rats, but reduce contralateral turning in hemiparkinsonian rats.
Topics: Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Functional Laterality; Histamine Agonists; Histamine Antagonists; Imidazoles; Male; Motor Activity; Oxidopamine; Piperidines; Rats; Rats, Wistar; Stereotyped Behavior; Substantia Nigra | 2004 |
Neuroprotective effect of L-DOPA co-administered with the adenosine A2A receptor agonist CGS 21680 in an animal model of Parkinson's disease.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Analysis of Variance; Animals; Antiparkinson Agents; Apomorphine; Cell Count; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Drug Therapy, Combination; Dyskinesias; Immunohistochemistry; Levodopa; Male; Oxidopamine; Parkinson Disease; Phenethylamines; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Sympatholytics; Time Factors; Tyrosine 3-Monooxygenase | 2004 |
Neurotrophic factor in the treatment of Parkinson disease.
Topics: Animals; Apomorphine; Astrocytes; Cell Differentiation; Cell Division; Cells, Cultured; Female; Fibroblast Growth Factor 2; Genetic Therapy; Glial Cell Line-Derived Neurotrophic Factor; Immunohistochemistry; Nerve Growth Factors; Neuroprotective Agents; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Stem Cell Transplantation; Stem Cells; Visual Cortex | 2003 |
Neuroprotective and neurotrophic effect of apomorphine in the striatal 6-OHDA-lesion rat model of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Behavior, Animal; Chromatography, High Pressure Liquid; Corpus Striatum; Dialysis; Disease Models, Animal; Dopamine; Drug Interactions; Electrochemistry; Hydroxybenzoates; Immunohistochemistry; Male; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Psychomotor Performance; Rats; Rats, Wistar; Stereotyped Behavior; Time Factors; Tyrosine 3-Monooxygenase; Ventral Tegmental Area | 2004 |
Preserved ipsilateral-to-lesion motor map organization in the unilateral 6-OHDA-treated rat model of Parkinson's disease.
Topics: Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Brain; Brain Mapping; Cell Count; Disease Models, Animal; Dopamine; Electric Stimulation; Forelimb; Functional Laterality; Immunohistochemistry; Male; Movement; Oxidopamine; Parkinson Disease; Psychomotor Performance; Rats; Rats, Long-Evans; Rotation; Sympatholytics; Tyrosine 3-Monooxygenase | 2004 |
Serotonergic influence on the potentiation of D-amphetamine and apomorphine-induced rotational behavior by the alpha2-adrenoceptor antagonist 2-methoxy idazoxan in hemiparkinsonian rats.
Topics: Adrenergic Agents; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Dextroamphetamine; Drug Synergism; Idazoxan; Male; Motor Activity; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Serotonin; Sympatholytics | 2005 |
Altered extracellular striatal in vivo biotransformation of the opioid neuropeptide dynorphin A(1-17) in the unilateral 6-OHDA rat model of Parkinson's disease.
Topics: Amino Acid Sequence; Animals; Apomorphine; Behavior, Animal; Brain Chemistry; Chromatography, Liquid; Corpus Striatum; Disease Models, Animal; Dynorphins; Mass Spectrometry; Microdialysis; Molecular Sequence Data; Oxidopamine; Parkinson Disease; Peptide Fragments; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization | 2005 |
Protective effects of N-acetylserotonin against 6-hydroxydopamine-induced neurotoxicity.
Topics: Animals; Apomorphine; Benzazepines; Binding, Competitive; Biogenic Monoamines; Cell Count; Dopamine; Dopamine Agonists; Dopamine Antagonists; Male; Microinjections; Neostriatum; Neurons; Neurotoxicity Syndromes; Oxidopamine; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Rotation; Serotonin; Stereotyped Behavior; Sympatholytics | 2005 |
Failure of FK506 (tacrolimus) to alleviate apomorphine-induced circling in rat Parkinson model in spite of some cytoprotective effects in SH-SY5Y dopaminergic cells.
Topics: Animals; Apomorphine; Behavior, Animal; Caspase 3; Caspases; Cell Death; Cell Line, Tumor; Disease Models, Animal; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Immunophilins; Male; Motor Activity; Nerve Degeneration; Neuroblastoma; Neurons; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Random Allocation; Rats; Rats, Wistar; Tacrolimus | 2005 |
Bilateral increase of perforated synapses after unilateral dopamine depletion.
Topics: Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Dopamine; Dopamine Agonists; Functional Laterality; Male; Microscopy, Electron, Transmission; Neuronal Plasticity; Oxidopamine; Presynaptic Terminals; Rats; Rats, Wistar; Stereotyped Behavior; Sympatholytics; Synapses | 2005 |
Ginkgo biloba affords dose-dependent protection against 6-hydroxydopamine-induced parkinsonism in rats: neurobehavioural, neurochemical and immunohistochemical evidences.
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Brain Chemistry; Catecholamines; Disease Models, Animal; Dopamine Agonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Ginkgo biloba; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Immunohistochemistry; Male; Motor Activity; Oxidopamine; Parkinsonian Disorders; Plant Extracts; Psychomotor Performance; Rats; Rats, Wistar; Receptors, Dopamine D2; Stereotyped Behavior; Substantia Nigra; Thiobarbituric Acid Reactive Substances; Tyrosine 3-Monooxygenase | 2005 |
Assessment of recovery in the hemiparkinson rat: drug-induced rotation is inadequate.
Topics: Animals; Apomorphine; Astrocytes; Behavioral Research; Brain Tissue Transplantation; Corpus Striatum; Denervation; Dopamine; Male; Motor Activity; Motor Skills; Oxidopamine; Parkinsonian Disorders; Perceptual Disorders; Rats; Rats, Inbred F344; Recovery of Function; Rotation; Stereotyped Behavior; Substantia Nigra; Treatment Outcome | 2005 |
Dopamine depletion increases the power and coherence of beta-oscillations in the cerebral cortex and subthalamic nucleus of the awake rat.
Topics: Adrenergic Agents; Animals; Apomorphine; Behavior, Animal; Beta Rhythm; Cerebral Cortex; Dopamine; Dopamine Agonists; Drug Interactions; Male; Mesencephalon; Neurons; Oxidopamine; Rats; Rotation; Spectrum Analysis; Stereotyped Behavior; Subthalamic Nucleus; Time Factors; Wakefulness | 2005 |
The role of the phosphatidyinositol-linked D1 dopamine receptor in the pharmacology of SKF83959.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Brain Chemistry; Dopamine Agonists; Dopamine Antagonists; Hippocampus; Inositol 1,4,5-Trisphosphate; Male; Neostriatum; Oxidopamine; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Stereotyped Behavior; Sympathectomy, Chemical; Sympatholytics; Type C Phospholipases | 2005 |
Behavioral characterization of a unilateral 6-OHDA-lesion model of Parkinson's disease in mice.
Topics: Adrenergic Agents; Amphetamine; Analysis of Variance; Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Cell Count; Disease Models, Animal; Drug Interactions; Exploratory Behavior; Female; Functional Laterality; Immunohistochemistry; Linear Models; Medial Forebrain Bundle; Mice; Mice, Inbred CBA; Motor Activity; Neurons; Oxidopamine; Parkinson Disease; Predictive Value of Tests; Psychomotor Performance; Rotarod Performance Test; Rotation; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase; Ventral Tegmental Area | 2005 |
Behavioural effects of parafascicular thalamic lesions in an animal model of parkinsonism.
Topics: Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Choice Behavior; Disease Models, Animal; Female; Grooming; Medial Forebrain Bundle; Motor Activity; Oxidopamine; Parkinsonian Disorders; Piloerection; Posture; Rats; Rats, Sprague-Dawley; Reaction Time; Reinforcement, Psychology; Stereotyped Behavior; Thalamic Nuclei; Vibrissae | 2005 |
Comparison of the capability of GDNF, BDNF, or both, to protect nigrostriatal neurons in a rat model of Parkinson's disease.
Topics: Adrenergic Agents; Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cell Count; Cell Line; Corpus Striatum; Cricetinae; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Functional Laterality; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Glial Cell Line-Derived Neurotrophic Factor; Immunohistochemistry; Nerve Growth Factors; Neurons; Oxidopamine; Parkinson Disease; Rats; Rotation; Simplexvirus; Substantia Nigra | 2005 |
The unilateral 6-OHDA rat model of Parkinson's disease revisited: an electromyographic and behavioural analysis.
Topics: Adrenergic Agents; Animals; Apomorphine; Behavior, Animal; Disease Models, Animal; Dopamine Agonists; Electromyography; Extremities; Female; Functional Laterality; Locomotion; Muscle, Skeletal; Oxidopamine; Parkinson Disease; Psychomotor Performance; Rats; Rats, Inbred Lew; Stereotyped Behavior; Substantia Nigra | 2005 |
Differential expression of striatal synaptotagmin mRNA isoforms in hemiparkinsonian rats.
Topics: Animals; Apomorphine; Behavior, Animal; Benzazepines; Brain; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Dopamine Antagonists; Drug Interactions; Female; Gene Expression; Gene Expression Regulation; In Situ Hybridization; Levodopa; Oxidopamine; Parkinsonian Disorders; Protein Isoforms; Rats; Rats, Wistar; RNA, Messenger; Rotation; Substantia Nigra; Synaptotagmins; Time Factors; Tyrosine 3-Monooxygenase | 2005 |
Transplants of neurosphere cell suspensions from aged mice are functional in the mouse model of Parkinson's.
Topics: Aging; Amphetamine; Animals; Apomorphine; Astrocytes; Behavior, Animal; Behavioral Symptoms; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Dopamine Uptake Inhibitors; Functional Laterality; Glial Fibrillary Acidic Protein; Green Fluorescent Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurofilament Proteins; Neurons; Oxidopamine; Parkinson Disease; Stem Cell Transplantation; Time Factors; Tyrosine 3-Monooxygenase | 2005 |
Stress reduces the neuroprotective effect of exercise in a rat model for Parkinson's disease.
Topics: Analysis of Variance; Animals; Apomorphine; Dopamine; Dopamine Agonists; Functional Laterality; Male; Medial Forebrain Bundle; Oxidopamine; Parkinsonian Disorders; Physical Conditioning, Animal; Random Allocation; Rats; Rats, Long-Evans; Running; Statistics, Nonparametric; Stress, Psychological; Sympathectomy, Chemical; Sympatholytics; Tyrosine 3-Monooxygenase | 2005 |
Olfactory ensheathing glial co-grafts improve functional recovery in rats with 6-OHDA lesions.
Topics: Amphetamine; Animals; Apomorphine; Astrocytes; Behavior, Animal; Brain; Cell Culture Techniques; Cell Transplantation; Dopamine; Immunohistochemistry; Male; Mesencephalon; Models, Animal; Myelin Sheath; Nerve Regeneration; Neuroglia; Olfactory Bulb; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Recovery of Function | 2005 |
Subchronic intermittent caffeine administration to unilaterally 6-hydroxydopamine-lesioned rats sensitizes turning behaviour in response to dopamine D(1) but not D(2) receptor agonists.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Caffeine; Central Nervous System Stimulants; Dopamine Agents; Dopamine Agonists; Levodopa; Male; Oxidopamine; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Stereotyped Behavior; Sympathectomy, Chemical; Sympatholytics | 2005 |
Correlation between quantitative imaging and behavior in unilaterally 6-OHDA-lesioned rats.
Topics: Animals; Apomorphine; Autoradiography; Behavior, Animal; Dopamine; Dopamine Agents; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Functional Laterality; Male; Methamphetamine; Movement; Neostriatum; Neurons; Oxidopamine; Parkinsonian Disorders; Positron-Emission Tomography; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2 | 2005 |
Physiological neuroprotection by melatonin in a 6-hydroxydopamine model of Parkinson's disease.
Topics: Animals; Apomorphine; Brain-Derived Neurotrophic Factor; Densitometry; Dopamine Agonists; Functional Laterality; Glial Cell Line-Derived Neurotrophic Factor; Immunohistochemistry; Male; Melatonin; Neostriatum; Neuroprotective Agents; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Receptor, Melatonin, MT1; Receptors, Melatonin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stereotyped Behavior; Sympatholytics; Tyrosine 3-Monooxygenase | 2006 |
Further validation of the corridor task for assessing deficit and recovery in the hemi-Parkinsonian rat: restoration of bilateral food retrieval by dopamine receptor agonism.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Behavior, Animal; Brain Chemistry; Chromatography, High Pressure Liquid; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agonists; Feeding Behavior; Functional Laterality; Homovanillic Acid; Oxidopamine; Parkinson Disease; Rats; Recovery of Function; Reproducibility of Results | 2006 |
Electrophysiological characterization of substantia nigra dopaminergic neurons in partially lesioned rats: effects of subthalamotomy and levodopa treatment.
Topics: Action Potentials; Adrenergic Agents; Animals; Apomorphine; Brain Injuries; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Immunohistochemistry; Levodopa; Male; Neurons; Oxidopamine; Rats; Rats, Sprague-Dawley; Substantia Nigra; Subthalamic Nucleus; Tyrosine 3-Monooxygenase | 2006 |
Colour-coded pellets increase the sensitivity of the staircase test to differentiate skilled forelimb performances of control and 6-hydroxydopamine lesioned rats.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Apomorphine; Appetitive Behavior; Behavior, Animal; Brain Injuries; Color Perception; Conditioning, Operant; Eating; Female; Forelimb; Functional Laterality; Oxidopamine; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Stereotyped Behavior | 2006 |
A novel therapeutic approach to 6-OHDA-induced Parkinson's disease in rats via supplementation of PTD-conjugated tyrosine hydroxylase.
Topics: Animals; Apomorphine; Blood-Brain Barrier; Brain Chemistry; Cell Line, Tumor; Gene Products, tat; Humans; Male; Oxidopamine; Parkinson Disease, Secondary; Peptide Fragments; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Rotation; Stereotyped Behavior; tat Gene Products, Human Immunodeficiency Virus; Transduction, Genetic; Tyrosine 3-Monooxygenase | 2006 |
Apomorphine protects against 6-hydroxydopamine-induced neuronal cell death through activation of the Nrf2-ARE pathway.
Topics: Adrenergic Agents; Apomorphine; Benzazepines; Cell Death; Cell Line, Tumor; Cell Survival; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Flow Cytometry; Heme Oxygenase-1; Humans; Neuroblastoma; NF-E2-Related Factor 2; Oxidopamine; Response Elements; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction | 2006 |
Control of dopamine-secretion by Tet-Off system in an in vivo model of parkinsonian rat.
Topics: Animals; Antiporters; Apomorphine; Bacterial Proteins; Behavior, Animal; Cell Transplantation; Disease Models, Animal; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Doxycycline; Female; Gene Expression Regulation; Humans; Immunohistochemistry; Oxidopamine; Parkinsonian Disorders; PC12 Cells; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rotarod Performance Test; Time Factors; Tyrosine 3-Monooxygenase | 2006 |
Rats with unilateral median forebrain bundle, but not striatal or nigral, lesions by the neurotoxins MPP+ or rotenone display differential sensitivity to amphetamine and apomorphine.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Dextroamphetamine; Dopamine; Male; Medial Forebrain Bundle; Oxidopamine; Rats; Rotation; Rotenone; Substantia Nigra | 2006 |
Neuroprotective effects of caffeine in the model of 6-hydroxydopamine lesion in rats.
Topics: Animals; Apomorphine; Brain; Brain Diseases; Caffeine; Disease Models, Animal; Dopamine Agents; Male; Neurons; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar | 2006 |
Tandospirone, a 5-HT1A agonist, ameliorates movement disorder via non-dopaminergic systems in rats with unilateral 6-hydroxydopamine-generated lesions.
Topics: Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Benzazepines; Brain Injuries; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Interactions; Functional Laterality; Isoindoles; Male; Movement Disorders; Oxidopamine; Piperazines; Pyridines; Pyrimidines; Rats; Rats, Wistar; Rotarod Performance Test; Serotonin Antagonists; Serotonin Receptor Agonists; Time Factors | 2006 |
Sexually dimorphic postural adjustments during vertical behaviour are altered in a unilateral 6-OHDA rat model of Parkinson's disease.
Topics: Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Biomechanical Phenomena; Disease Models, Animal; Dopamine Agonists; Female; Functional Laterality; Immunohistochemistry; Male; Movement; Oxidopamine; Parkinson Disease; Posture; Psychomotor Performance; Rats; Rats, Long-Evans; Rotarod Performance Test; Sex Characteristics; Sex Factors; Tyrosine 3-Monooxygenase | 2006 |
Dopaminergic neuroprotection by neurturin-expressing c17.2 neural stem cells in a rat model of Parkinson's disease.
Topics: Adrenergic Agents; Animals; Apomorphine; Behavior, Animal; Cell Count; Cell Line; Disease Models, Animal; Dopamine; Male; Motor Activity; Nerve Tissue Proteins; Neuroprotective Agents; Neurturin; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Stem Cell Transplantation; Stem Cells; Tyrosine 3-Monooxygenase | 2007 |
Neurotensin polyplex as an efficient carrier for delivering the human GDNF gene into nigral dopamine neurons of hemiparkinsonian rats.
Topics: Animals; Apomorphine; Corpus Striatum; Dopamine; Genetic Therapy; Genetic Vectors; Glial Cell Line-Derived Neurotrophic Factor; Humans; Immunohistochemistry; Methamphetamine; Nanoparticles; Neurons; Neurotensin; Oxidopamine; Parkinson Disease, Secondary; Rats; Substantia Nigra; Time Factors; Transfection | 2006 |
Catha edulis extract and its active principle cathinone induce ipsilateral rotation in unilaterally lesioned rats.
Topics: Alkaloids; Animals; Apomorphine; Catha; Central Nervous System Stimulants; Dopamine Agonists; Functional Laterality; Male; Medial Forebrain Bundle; Oxidopamine; Plant Extracts; Rats; Rats, Sprague-Dawley; Rotation; Stereotyped Behavior | 2006 |
Loss of dopaminergic responsiveness in a double lesion rat model of the Parkinson variant of multiple system atrophy.
Topics: Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Disease Models, Animal; Functional Laterality; Levodopa; Male; Multiple System Atrophy; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Substantia Nigra | 2007 |
Sequential bilateral striatal lesions have additive effects on single skilled limb use in rats.
Topics: Adrenergic Agents; Animals; Apomorphine; Behavior, Animal; Brain Injuries; Corpus Striatum; Dopamine Agonists; Drug Administration Schedule; Extremities; Functional Laterality; Male; Motor Activity; Motor Skills; Oxidopamine; Rats; Rats, Long-Evans; Rotarod Performance Test; Tyrosine 3-Monooxygenase; Walking | 2007 |
Transplantation of bone marrow stromal cells containing the neurturin gene in rat model of Parkinson's disease.
Topics: Animals; Apomorphine; Bone Marrow Transplantation; Cells, Cultured; Disease Models, Animal; Dopamine; Female; Glial Fibrillary Acidic Protein; Green Fluorescent Proteins; Humans; In Situ Hybridization; Motor Activity; Neurturin; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Stromal Cells; Transfection; Tyrosine 3-Monooxygenase | 2007 |
Effects of engrafted neural stem cells derived from GFP transgenic mice in Parkinson's diseases rats.
Topics: Animals; Animals, Newborn; Antiparkinson Agents; Apomorphine; Behavior, Animal; Disease Models, Animal; Glial Fibrillary Acidic Protein; Green Fluorescent Proteins; Mice; Mice, Transgenic; Neurons; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Stem Cell Transplantation; Stem Cells; Stereotyped Behavior; Sympatholytics; Time Factors; Transplantation, Heterologous; Tyrosine 3-Monooxygenase | 2007 |
Experimental change on dopaminergic neurons in striatum of Parkinson disease rats.
Topics: Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agonists; Male; Motor Activity; Neurons; Oxidopamine; Parkinson Disease, Secondary; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; Stereotypic Movement Disorder; Substantia Nigra; Up-Regulation | 2007 |
Treadmill exercise suppresses nigrostriatal dopaminergic neuronal loss in 6-hydroxydopamine-induced Parkinson's rats.
Topics: Animals; Apomorphine; Cell Survival; Dopamine; Dopamine Agonists; Immunohistochemistry; Male; Neostriatum; Nerve Fibers; Neurons; Oxidopamine; Parkinson Disease, Secondary; Physical Conditioning, Animal; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Substantia Nigra; Sympatholytics; Tyrosine 3-Monooxygenase | 2007 |
The corticotrophin-releasing factor-like peptide urocortin reverses key deficits in two rodent models of Parkinson's disease.
Topics: Animals; Apomorphine; Blotting, Western; Corticotropin-Releasing Hormone; Data Interpretation, Statistical; Dopamine; Lipopolysaccharides; Male; Neostriatum; Nerve Tissue Proteins; Neuroprotective Agents; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Wistar; Stereotyped Behavior; Substantia Nigra; Sympatholytics; Tyrosine 3-Monooxygenase; Urocortins | 2007 |
A comparison of dopaminergic cells from the human NTera2/D1 cell line transplanted into the hemiparkinsonian rat.
Topics: Animals; Apomorphine; Behavior, Animal; Cell Line; Cell Transplantation; Dopamine; Dopamine Agonists; Graft Survival; Humans; Image Processing, Computer-Assisted; Immunohistochemistry; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Stereotyped Behavior; Sympatholytics; Tyrosine 3-Monooxygenase | 2007 |
A golgi analysis of cortical pyramidal cells in the unilateral parkinson rat: absence of change in the affected hemisphere vs hypertrophy in the intact hemisphere.
Topics: Animals; Apomorphine; Cerebral Cortex; Dendrites; Dendritic Spines; Dextroamphetamine; Female; Forelimb; Golgi Apparatus; Hypertrophy; Motor Activity; Motor Cortex; Oxidopamine; Parkinson Disease, Secondary; Psychomotor Performance; Pyramidal Cells; Rats; Rats, Long-Evans; Rotation; Synapses | 2007 |
Unilateral implantation of dopamine-loaded biodegradable hydrogel in the striatum attenuates motor abnormalities in the 6-hydroxydopamine model of hemi-parkinsonism.
Topics: Absorbable Implants; Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Dopamine; Drug Delivery Systems; Drug Interactions; Functional Laterality; Male; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Rotarod Performance Test; Stereotyped Behavior; Time Factors; Tyrosine 3-Monooxygenase | 2007 |
MIF-1 and its peptidomimetic analogs attenuate haloperidol-induced vacuous chewing movements and modulate apomorphine-induced rotational behavior in 6-hydroxydopamine-lesioned rats.
Topics: Animals; Apomorphine; Behavior, Animal; Haloperidol; Male; Mastication; Molecular Mimicry; MSH Release-Inhibiting Hormone; Oxidopamine; Rats; Rats, Sprague-Dawley; Substantia Nigra | 2007 |
Generation of a alpha-synuclein-based rat model of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Agents; alpha-Synuclein; Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Disease Models, Animal; Dopamine Agonists; Gene Expression Regulation; Gene Products, tat; Genetic Vectors; Green Fluorescent Proteins; Male; Motor Activity; Oxidopamine; Parkinson Disease; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase | 2008 |
Hemiparkinsonian rats rotate toward the side with the weaker dopaminergic neurotransmission.
Topics: Analysis of Variance; Animals; Apomorphine; Brain Damage, Chronic; Disease Models, Animal; Dopamine; Dopamine Agonists; Functional Laterality; Locomotion; Male; Motor Activity; MPTP Poisoning; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Rotation; Severity of Illness Index; Statistics, Nonparametric; Substantia Nigra | 2008 |
Lack of robust protective effect of quercetin in two types of 6-hydroxydopamine-induced parkinsonian models in rats and dopaminergic cell cultures.
Topics: Amphetamine; Animals; Antioxidants; Apomorphine; Behavior, Animal; Cell Line, Tumor; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Humans; L-Lactate Dehydrogenase; Male; Motor Activity; Neuroblastoma; Oxidopamine; Parkinson Disease; Quercetin; Rats; Rats, Wistar; Substantia Nigra; Tetrazolium Salts; Thiazoles; Tyrosine 3-Monooxygenase | 2008 |
Apomorphine-induced turning behavior in 6-hydroxydopamine lesioned rats is increased by histidine and decreased by histidine decarboxylase, histamine H1 and H2 receptor antagonists, and an H3 receptor agonist.
Topics: Animals; Apomorphine; Basal Ganglia; Enzyme Inhibitors; Histamine Agonists; Histamine H1 Antagonists; Histamine H2 Antagonists; Histidine; Histidine Decarboxylase; Imidazoles; Injections, Intraventricular; Male; Methylhistidines; Narcotic Antagonists; Oxidopamine; Piperidines; Pyrilamine; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Sympatholytics; Synapses; Thiourea | 2008 |
Glucagon-like peptide 1 receptor stimulation reverses key deficits in distinct rodent models of Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Corpus Striatum; Dopamine; Drug Evaluation, Preclinical; Endotoxins; Exenatide; Glucagon-Like Peptide-1 Receptor; Levodopa; Locomotion; Male; Nerve Tissue Proteins; Oxidopamine; Parkinsonian Disorders; Peptides; Rats; Rats, Wistar; Receptors, Glucagon; Substantia Nigra; Tyrosine 3-Monooxygenase; Venoms | 2008 |
Apomorphine-induced differences in cortical and striatal EEG and their glutamatergic mediation in 6-hydroxydopamine-treated rats.
Topics: Alpha Rhythm; Animals; Apomorphine; Behavior, Animal; Beta Rhythm; Cerebral Cortex; Corpus Striatum; Delta Rhythm; Disease Models, Animal; Dizocilpine Maleate; Dopamine Agonists; Drug Interactions; Electroencephalography; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Osmotic Fragility; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Sympatholytics; Theta Rhythm | 2008 |
Intermittent L-DOPA treatment differentially alters synaptotagmin 4 and 7 gene expression in the striatum of hemiparkinsonian rats.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Female; Functional Laterality; Gene Expression; Levodopa; Motor Activity; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; RNA, Messenger; Synaptotagmins; Time Factors | 2008 |
Preventive effects of genistein on motor dysfunction following 6-hydroxydopamine injection in ovariectomized rats.
Topics: Adrenergic Agents; Animals; Apomorphine; Dopamine Agonists; Dose-Response Relationship, Drug; Exploratory Behavior; Female; Genistein; Motor Activity; Movement Disorders; Neurons; Ovariectomy; Oxidopamine; Phytoestrogens; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Tyrosine 3-Monooxygenase | 2008 |
Both pre- and post-lesion experiential therapy is beneficial in 6-hydroxydopamine dopamine-depleted female rats.
Topics: Animals; Apomorphine; Corticosterone; Disease Models, Animal; Dopamine; Environment; Exploratory Behavior; Female; Functional Laterality; Hippocampus; Locomotion; Microtubule-Associated Proteins; Motor Skills; Neurotoxicity Syndromes; Neurotoxins; Oxidopamine; Rats; Rats, Long-Evans; Tyrosine 3-Monooxygenase | 2009 |
Priming of rotational behavior by a dopamine receptor agonist in Hemiparkinsonian rats: movement-dependent induction.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Disease Models, Animal; Dopamine; Dopamine Agonists; Enzyme Inhibitors; Functional Laterality; Male; Metyrapone; Movement; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Restraint, Physical; Rotarod Performance Test; Rotation; Time Factors | 2009 |
Combined treatment of neurotrophin-3 gene and neural stem cells is ameliorative to behavior recovery of Parkinson's disease rat model.
Topics: Animals; Apomorphine; Behavior, Animal; Cell Movement; Cells, Cultured; Disease Models, Animal; Dopamine; Genetic Therapy; Maze Learning; Medial Forebrain Bundle; Motor Activity; Nerve Degeneration; Neurogenesis; Neurons; Neurotrophin 3; Oxidopamine; Parkinsonian Disorders; Rats; Stem Cell Transplantation; Stem Cells; Tyrosine 3-Monooxygenase; Ventral Tegmental Area | 2009 |
Local administration of sarizotan into the subthalamic nucleus attenuates levodopa-induced dyskinesias in 6-OHDA-lesioned rats.
Topics: Animals; Apomorphine; Benserazide; Dopamine Agents; Dopamine Plasma Membrane Transport Proteins; Dyskinesia, Drug-Induced; Immunohistochemistry; Levodopa; Male; Microinjections; Organic Chemicals; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Rotation; Serotonin Receptor Agonists; Stereotyped Behavior; Subthalamic Nucleus; Sympathectomy, Chemical; Sympatholytics | 2009 |
Nicotine induces sensitization of turning behavior in 6-hydroxydopamine lesioned rats.
Topics: Adrenergic Agents; Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Chromatography, High Pressure Liquid; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Electrochemistry; Functional Laterality; Ganglionic Stimulants; Male; Nicotine; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar; Time Factors | 2009 |
Histaminergic activity in a rodent model of Parkinson's disease.
Topics: Adrenergic Agents; Animals; Animals, Newborn; Apomorphine; Brain; Disease Models, Animal; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Exploratory Behavior; Histamine; Histamine Antagonists; Locomotion; Male; Mouth Abnormalities; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar | 2009 |
Treatment of Parkinson's disease model mice with allogeneic embryonic stem cells: necessity of immunosuppressive treatment for sustained improvement.
Topics: Animals; Apomorphine; Corpus Striatum; Cyclosporine; Disease Models, Animal; Embryonic Stem Cells; Immunosuppressive Agents; Lymphocyte Activation; Male; Mice; Mice, Inbred Strains; Motor Activity; Oxidopamine; Parkinson Disease; Stem Cell Transplantation; Time Factors; Transplantation, Homologous; Tyrosine 3-Monooxygenase | 2009 |
D2 receptor stimulation, but not D1, restores striatal equilibrium in a rat model of Parkinsonism.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Action Potentials; Animals; Antiparkinson Agents; Apomorphine; Benserazide; Corpus Striatum; Disease Models, Animal; Dopamine Agents; Dopamine Agonists; Levodopa; Male; Neurons; Oxidopamine; Parkinsonian Disorders; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2 | 2009 |
Chronic, systemic treatment with a metabotropic glutamate receptor 5 antagonist in 6-hydroxydopamine partially lesioned rats reverses abnormal firing of dopaminergic neurons.
Topics: Animals; Apomorphine; Dopamine; Dopamine Agonists; Electrophysiology; Excitatory Amino Acid Antagonists; Immunohistochemistry; Male; Microelectrodes; Neurons; Oxidopamine; Parkinsonian Disorders; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Dopamine; Receptors, Metabotropic Glutamate; Tyrosine 3-Monooxygenase | 2009 |
Investigation of neuroprotective effects of cyclooxygenase inhibitors in the 6-hydroxydopamine induced rat Parkinson model.
Topics: Amphetamines; Animals; Antiparkinson Agents; Apomorphine; Aspirin; Behavior, Animal; Cyclooxygenase Inhibitors; Disease Models, Animal; Female; Immunohistochemistry; Meloxicam; Neuroprotective Agents; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Sympatholytics; Thiazines; Thiazoles | 2009 |
Intrapallidal injection of 6-hydroxydopamine induced changes in dopamine innervation and neuronal activity of globus pallidus.
Topics: Action Potentials; Adrenergic Agents; Animals; Apomorphine; Axons; Cell Death; Corpus Striatum; Dopamine; Dopamine Agonists; Globus Pallidus; Male; Motor Activity; Neural Pathways; Neurons; Oxidopamine; Rats; Rats, Wistar; Substantia Nigra; Tyrosine 3-Monooxygenase | 2009 |
Noradrenergic lesion of the locus coeruleus increases apomorphine-induced circling behavior and the firing activity of substantia nigra pars reticulata neurons in a rat model of Parkinson's disease.
Topics: Action Potentials; Adrenergic Agents; Animals; Apomorphine; Disease Models, Animal; Locus Coeruleus; Male; Movement; Neurons; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Substantia Nigra; Tyrosine 3-Monooxygenase | 2010 |
Metabotropic glutamate 7 receptor subtype modulates motor symptoms in rodent models of Parkinson's disease.
Topics: Allosteric Regulation; Animals; Apomorphine; Benzhydryl Compounds; Catalepsy; Disease Models, Animal; Haloperidol; Male; Mice; Mice, Knockout; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Wistar; Reaction Time; Receptors, Metabotropic Glutamate; Stereotyped Behavior | 2010 |
Evaluation of chronic omega-3 fatty acids supplementation on behavioral and neurochemical alterations in 6-hydroxydopamine-lesion model of Parkinson's disease.
Topics: Animals; Apomorphine; Brain; Cell Membrane; Disease Models, Animal; Dopamine; Dopamine Agonists; Fatty Acids, Omega-3; Lipid Peroxidation; Male; Motor Activity; Neurons; Oxidopamine; Parkinsonian Disorders; Random Allocation; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Treatment Outcome; Tyrosine 3-Monooxygenase | 2010 |
Unilateral lesion of the nigrostriatal pathway decreases the response of interneurons in medial prefrontal cortex to 5-HT 2A/2C receptor stimulation in the rat.
Topics: Action Potentials; Adrenergic Agents; Aminopyridines; Amphetamines; Analysis of Variance; Animals; Apomorphine; Corpus Striatum; Dopamine Agonists; Dose-Response Relationship, Drug; Indoles; Interneurons; Male; Neural Pathways; Oxidopamine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Agents; Substantia Nigra; Tyrosine 3-Monooxygenase | 2010 |
Therapeutic effect of human amniotic epithelial cell transplantation into the lateral ventricle of hemiparkinsonian rats.
Topics: Amnion; Animals; Apomorphine; Chromatography, High Pressure Liquid; Epithelial Cells; Female; Homovanillic Acid; Humans; Immunohistochemistry; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley | 2009 |
Alterations of Hrd1 expression in various encephalic regional neurons in 6-OHDA model of Parkinson's disease.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Apomorphine; Brain; Disease Models, Animal; Male; Neurons; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Sympatholytics; Ubiquitin-Protein Ligases; Up-Regulation | 2010 |
Dopamine neuron stimulating actions of a GDNF propeptide.
Topics: Animals; Apomorphine; Disease Models, Animal; Dopamine; Glial Cell Line-Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor Receptors; Isoflurane; Male; Nerve Growth Factors; Neurons; Oligopeptides; Oxidopamine; Rats; Rats, Inbred F344; Signal Transduction; Substantia Nigra | 2010 |
An in vivo pharmacological evaluation of pardoprunox (SLV308)--a novel combined dopamine D(2)/D(3) receptor partial agonist and 5-HT(1A) receptor agonist with efficacy in experimental models of Parkinson's disease.
Topics: Animals; Apomorphine; Benzoxazoles; Callithrix; Dopamine Agonists; Female; Male; Mice; Motor Activity; Oxidopamine; Parkinsonian Disorders; Piperazines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine D2; Receptors, Dopamine D3; Serotonin 5-HT1 Receptor Agonists; Sulpiride | 2010 |
Differing short-term neuroprotective effects of the fibrates fenofibrate and bezafibrate in MPTP and 6-OHDA experimental models of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Apomorphine; Bezafibrate; Cell Count; Disease Models, Animal; Drug Interactions; Exploratory Behavior; Fenofibrate; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Oxidopamine; Parkinsonian Disorders; Statistics, Nonparametric; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase; Ventral Tegmental Area | 2010 |
Characterisation of behavioural and neurodegenerative changes induced by intranigral 6-hydroxydopamine lesions in a mouse model of Parkinson's disease.
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Disease Models, Animal; Dopamine; Dopamine Agents; Dopamine Agonists; Female; Mice; Nerve Degeneration; Neural Pathways; Neuropsychological Tests; Oxidopamine; Parkinson Disease; Substantia Nigra; Sympatholytics | 2010 |
Oral pelargonidin exerts dose-dependent neuroprotection in 6-hydroxydopamine rat model of hemi-parkinsonism.
Topics: Administration, Oral; Animals; Anthocyanins; Antiparkinson Agents; Apomorphine; Cell Count; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Functional Laterality; Lipid Peroxidation; Male; Mesencephalon; Neurons; Neuroprotective Agents; Nitric Oxide; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Statistics, Nonparametric; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2010 |
A water extract of Mucuna pruriens provides long-term amelioration of parkinsonism with reduced risk for dyskinesias.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Apomorphine; Benserazide; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Dyskinesia, Drug-Induced; Female; Forelimb; Mucuna; Oxidopamine; Parkinsonian Disorders; Phytotherapy; Plant Extracts; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Rotation; Time Factors; Tyrosine 3-Monooxygenase; Vibrissae | 2010 |
Antiparkinsonian trophic action of glial cell line-derived neurotrophic factor and transforming growth factor β1 is enhanced after co-infusion in rats.
Topics: Algorithms; Amphetamine; Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Blotting, Western; Central Nervous System Stimulants; Dopamine Agonists; Glial Cell Line-Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor Receptors; Immunohistochemistry; Infusion Pumps, Implantable; Male; Microinjections; Neostriatum; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Wistar; Stereotyped Behavior; Sympatholytics; Transforming Growth Factor beta1 | 2010 |
Effects of unilateral 6-OHDA lesions on [3H]-N-propylnorapomorphine binding in striatum ex vivo and vulnerability to amphetamine-evoked dopamine release in rat.
Topics: Amphetamine; Animals; Apomorphine; Binding, Competitive; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agonists; Dopamine Uptake Inhibitors; Male; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley | 2011 |
Peroxiredoxin-2 protects against 6-hydroxydopamine-induced dopaminergic neurodegeneration via attenuation of the apoptosis signal-regulating kinase (ASK1) signaling cascade.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Animals; Apomorphine; Brain; Cell Differentiation; Cell Line, Tumor; Cell Survival; Cytochromes; Disease Models, Animal; Dopamine; Enzyme Inhibitors; Female; Gene Expression Regulation; Green Fluorescent Proteins; Humans; Indoles; Male; MAP Kinase Kinase Kinase 5; Mice; Mice, Inbred C57BL; Middle Aged; Motor Activity; Neurodegenerative Diseases; Neuroprostanes; Oxidopamine; Parkinson Disease; Peroxiredoxins; Postmortem Changes; RNA, Small Interfering; Signal Transduction; Thioredoxins | 2011 |
Time-course gait analysis of hemiparkinsonian rats following 6-hydroxydopamine lesion.
Topics: Analysis of Variance; Animals; Apomorphine; Disease Models, Animal; Disease Progression; Functional Laterality; Gait Disorders, Neurologic; Male; Medial Forebrain Bundle; Movement; Oxidopamine; Parkinsonian Disorders; Psychomotor Performance; Rats; Rats, Wistar; Stereotyped Behavior; Sympatholytics; Time Factors; Tyrosine 3-Monooxygenase; Videotape Recording | 2011 |
Dopamine release from serotonergic nerve fibers is reduced in L-DOPA-induced dyskinesia.
Topics: Adrenergic Agents; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopa Decarboxylase; Dopamine; Dyskinesia, Drug-Induced; Electrochemistry; Female; Functional Laterality; Levodopa; Oxidopamine; Potassium Chloride; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Plasma Membrane Transport Proteins; Severity of Illness Index; Stereotyped Behavior; Tyrosine 3-Monooxygenase | 2011 |
Significant effects of 4-aminopyridine and tetraethylammonium in the treatment of 6-hydroxydopamine-induced Parkinson's disease.
Topics: 4-Aminopyridine; Animals; Apomorphine; Behavior, Animal; Disease Models, Animal; Drug Interactions; Male; Medial Forebrain Bundle; Microinjections; Oxidopamine; Parkinson Disease, Secondary; Potassium Channel Blockers; Rats; Rats, Wistar; Tetraethylammonium | 2011 |
Alterations of emotion, cognition and firing activity of the basolateral nucleus of the amygdala after partial bilateral lesions of the nigrostriatal pathway in rats.
Topics: Action Potentials; Adrenergic Agents; Amygdala; Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Cognition; Corpus Striatum; Emotions; Excitatory Amino Acid Agonists; Humans; Ibotenic Acid; Male; Motor Activity; Neural Pathways; Neurons; Neuropsychological Tests; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Substantia Nigra | 2011 |
Progesterone prevents depression-like behavior in a model of Parkinson's disease induced by 6-hydroxydopamine in male rats.
Topics: Amphetamine; Animals; Antidepressive Agents; Apomorphine; Cues; Depression; Dopamine Agonists; Male; Memory; Oxidopamine; Parkinson Disease, Secondary; Progesterone; Rats; Rats, Sprague-Dawley; Recognition, Psychology; Stereotyped Behavior; Swimming; Sympatholytics | 2011 |
Effects of chronic, systemic treatment with the dopamine receptor agonist R-apomorphine in partially lesioned rat model of Parkinson's disease: an electrophysiological study of substantia nigra dopamine neurons.
Topics: Action Potentials; Animals; Apomorphine; Cell Count; Disease Models, Animal; Dopamine Agonists; Male; Neurons; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Substantia Nigra; Sympatholytics; Tyrosine 3-Monooxygenase | 2011 |
L-type Cav1.2 calcium channel is involved in 6-hydroxydopamine-induced neurotoxicity in rats.
Topics: Animals; Antiparkinson Agents; Apomorphine; Calcium Channel Blockers; Calcium Channels, L-Type; Dopamine; Dopaminergic Neurons; Drug Interactions; Female; Nifedipine; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; RNA, Messenger; Substantia Nigra; Sympatholytics | 2012 |
Neuroprotective effects of neurokinin receptor one in dopaminergic neurons are mediated through Akt/PKB cell signaling pathway.
Topics: Analysis of Variance; Animals; Apomorphine; bcl-Associated Death Protein; Caspase 3; Cell Death; Cell Line, Tumor; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Dopaminergic Neurons; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Gene Expression Regulation; L-Lactate Dehydrogenase; Male; Motor Activity; Neuroblastoma; Neurokinin-1 Receptor Antagonists; Neuroprotective Agents; Neurotoxicity Syndromes; Oxidopamine; Peptide Fragments; Proto-Oncogene Proteins c-akt; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Rotarod Performance Test; Signal Transduction; Substance P; Sympatholytics; Time Factors; Tyrosine 3-Monooxygenase | 2011 |
Extent of pre-operative L-DOPA-induced dyskinesia predicts the severity of graft-induced dyskinesia after fetal dopamine cell transplantation.
Topics: Amphetamines; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine Agents; Dopamine Agonists; Dopaminergic Neurons; Dyskinesia, Drug-Induced; Dyskinesias; Female; Fetal Tissue Transplantation; Levodopa; Oxidopamine; Postoperative Complications; Predictive Value of Tests; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Substantia Nigra; Sympatholytics | 2011 |
Unilateral nigrostriatal 6-hydroxydopamine lesions in mice II: predicting l-DOPA-induced dyskinesia.
Topics: Adrenergic Agents; Animals; Apomorphine; Corpus Striatum; Dopamine Agonists; Dyskinesia, Drug-Induced; Levodopa; Mice; Motor Activity; Neurons; Oxidopamine; Rotarod Performance Test; Substantia Nigra | 2012 |
The involvement of RGS9 in l-3,4-dihydroxyphenylalanine-induced dyskinesias in unilateral 6-OHDA lesion rat model.
Topics: Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Benserazide; Disease Models, Animal; Dopamine Agents; Dyskinesia, Drug-Induced; Levodopa; Male; Motor Activity; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; RGS Proteins | 2011 |
Behavioral and histological analysis of a partial double-lesion model of parkinson-variant multiple system atrophy.
Topics: Animals; Apomorphine; Cell Count; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Dopamine and cAMP-Regulated Phosphoprotein 32; Exploratory Behavior; Female; Functional Laterality; Gait Disorders, Neurologic; Motor Activity; Multiple System Atrophy; Oxidopamine; Parkinson Disease; Psychomotor Performance; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Tyrosine 3-Monooxygenase | 2012 |
High intake of folic acid or complex of B vitamins provides anti-Parkinsonism effect: no role for serum level of homocysteine.
Topics: Adrenergic Agents; Animals; Antiparkinson Agents; Apomorphine; Area Under Curve; Disease Models, Animal; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Folic Acid; Homocysteine; Male; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Statistics, Nonparametric; Stereotyped Behavior; Vitamin B Complex | 2012 |
Neuroprotection by silencing iNOS expression in a 6-OHDA model of Parkinson's disease.
Topics: Adenoviridae; Animals; Antiparkinson Agents; Apomorphine; Apoptosis; Cell Line; Corpus Striatum; Dopaminergic Neurons; Humans; Kidney; Macrophages; Male; Mice; Microglia; Motor Activity; Nitric Oxide Synthase Type II; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; RNA, Small Interfering; Sympatholytics; Tumor Suppressor Protein p53 | 2012 |
DJ-1 protein protects dopaminergic neurons against 6-OHDA/MG-132-induced neurotoxicity in rats.
Topics: alpha-Synuclein; Animals; Antiparkinson Agents; Apomorphine; Corpus Striatum; Dopamine; Dopaminergic Neurons; Drug Evaluation, Preclinical; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Intracellular Signaling Peptides and Proteins; Ion Channels; Leupeptins; Male; Microinjections; Mitochondrial Membrane Transport Proteins; Mitochondrial Proteins; Mitochondrial Uncoupling Proteins; Motor Activity; Nerve Tissue Proteins; Neuroprotective Agents; Oncogene Proteins; Oxidative Stress; Oxidopamine; Parkinsonian Disorders; Protein Deglycase DJ-1; Rats; Rats, Sprague-Dawley; Substantia Nigra; Superoxide Dismutase; Tyrosine 3-Monooxygenase | 2012 |
Anti-apoptotic and anti-inflammatory effect of Piperine on 6-OHDA induced Parkinson's rat model.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Apomorphine; Apoptosis; Behavior, Animal; Benzodioxoles; Disease Models, Animal; Male; Oxidative Stress; Oxidopamine; Parkinson Disease; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Wistar | 2013 |
Survival and functional restoration of human fetal ventral mesencephalon following transplantation in a rat model of Parkinson's disease.
Topics: Animals; Apomorphine; Behavior, Animal; Disease Models, Animal; Embryo, Mammalian; Female; Graft Survival; Humans; Mesencephalon; Neurons; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Transplantation, Heterologous; Tyrosine 3-Monooxygenase | 2013 |
High frequency electro-acupuncture enhances striatum DAT and D1 receptor expression, but decreases D2 receptor level in 6-OHDA lesioned rats.
Topics: Acupuncture Points; Acupuncture Therapy; Analysis of Variance; Animals; Apomorphine; Biophysical Phenomena; Chromatography, High Pressure Liquid; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agonists; Dopamine Plasma Membrane Transport Proteins; Gene Expression Regulation; Male; Movement Disorders; Neurons; Neurotoxicity Syndromes; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; RNA, Messenger; Sympatholytics | 2013 |
Transplantation of neural stem cells co-transfected with Nurr1 and Brn4 for treatment of Parkinsonian rats.
Topics: Adrenergic Agents; Animals; Apomorphine; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agonists; Dopamine Plasma Membrane Transport Proteins; Green Fluorescent Proteins; Male; Nerve Tissue Proteins; Nuclear Receptor Subfamily 4, Group A, Member 2; Oxidopamine; Parkinsonian Disorders; POU Domain Factors; Rats; Rats, Sprague-Dawley; Stem Cell Transplantation; Time Factors; Transfection; Tyrosine 3-Monooxygenase | 2013 |
Is nicotine protective against Parkinson's disease? An experimental analysis.
Topics: Amphetamine; Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agents; Dopamine D2 Receptor Antagonists; Dopamine Uptake Inhibitors; Interneurons; Male; Nerve Tissue Proteins; Neuroprotective Agents; Nicotine; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Substantia Nigra | 2012 |
Neural stem cells transplanted in a mouse model of Parkinson's disease differentiate to neuronal phenotypes and reduce rotational deficit.
Topics: Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Cell Differentiation; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Embryo, Mammalian; GABAergic Neurons; Graft Survival; Green Fluorescent Proteins; Membrane Proteins; Mice; Mice, Inbred Strains; Mice, Transgenic; Nerve Tissue Proteins; Neural Stem Cells; Neurons; Oxidopamine; Parkinson Disease; Substantia Nigra; Tubulin | 2012 |
Therapeutic deep brain stimulation in Parkinsonian rats directly influences motor cortex.
Topics: Action Potentials; Adrenergic Agents; Afferent Pathways; Animals; Antiparkinson Agents; Apomorphine; Biophysics; Brain Mapping; Deep Brain Stimulation; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Evoked Potentials, Motor; Functional Laterality; Locomotion; Male; Medial Forebrain Bundle; Motor Cortex; Neurons; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Statistics as Topic; Subthalamic Nucleus | 2012 |
PGE2 EP1 receptor deletion attenuates 6-OHDA-induced Parkinsonism in mice: old switch, new target.
Topics: Animals; Apomorphine; Dinoprostone; Dopamine Agonists; Dopaminergic Neurons; Injections; Medial Forebrain Bundle; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Targeted Therapy; Nerve Tissue Proteins; Oxidopamine; Parkinsonian Disorders; Receptors, Prostaglandin E, EP1 Subtype; Substantia Nigra; Tyrosine 3-Monooxygenase | 2013 |
Study of the antidyskinetic effect of eltoprazine in animal models of levodopa-induced dyskinesia.
Topics: Amantadine; Amphetamine; Animals; Apomorphine; Disease Models, Animal; Dopamine Agents; Dyskinesia, Drug-Induced; Female; Levodopa; Macaca fascicularis; Medial Forebrain Bundle; Motor Activity; Oxidopamine; Parkinson Disease; Parkinsonian Disorders; Piperazines; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists; Time Factors; Tyrosine 3-Monooxygenase | 2013 |
BDNF receptor blockade hinders the beneficial effects of exercise in a rat model of Parkinson's disease.
Topics: Analysis of Variance; Animals; Apomorphine; Carbazoles; Corpus Striatum; Disease Models, Animal; Enzyme Inhibitors; Exercise Test; Exercise Therapy; Gene Expression Regulation; Indole Alkaloids; Male; Oxidopamine; Parkinson Disease; Putamen; Rats; Rats, Wistar; Receptor, trkB; Stereotyped Behavior; Time Factors; Tyrosine 3-Monooxygenase | 2013 |
Alpha-lipoic acid protects against 6-hydroxydopamine-induced neurotoxicity in a rat model of hemi-parkinsonism.
Topics: Adrenergic Agents; Animals; Apomorphine; Disease Models, Animal; Dose-Response Relationship, Drug; Functional Laterality; Malondialdehyde; Neurons; Neuroprotective Agents; Oxidopamine; Parkinsonian Disorders; Rats; Rotation; Substantia Nigra; Thioctic Acid | 2013 |
Performance of movement in hemiparkinsonian rats influences the modifications induced by dopamine agonists in striatal efferent dynorphinergic neurons.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adrenergic Agents; Analysis of Variance; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Dynorphins; Early Growth Response Protein 1; Enkephalins; Functional Laterality; Gene Expression Regulation; Male; Motor Neurons; Movement; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2013 |
Neuroprotective effect of sulforaphane in 6-hydroxydopamine-lesioned mouse model of Parkinson's disease.
Topics: Actinin; Adrenergic Agents; Analysis of Variance; Animals; Apomorphine; Caspase 3; Disease Models, Animal; DNA Fragmentation; Dopamine Agonists; Glutathione; Glutathione Reductase; Glutathione Transferase; Isothiocyanates; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Psychomotor Performance; Rotarod Performance Test; Rotation; Sulfoxides; Tyrosine 3-Monooxygenase | 2013 |
Puerarin attenuates neuronal degeneration and blocks oxidative stress to elicit a neuroprotective effect on substantia nigra injury in 6-OHDA-lesioned rats.
Topics: Adrenergic Agents; Animals; Apomorphine; Brain Injuries; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Isoflavones; Male; Malondialdehyde; Microtubule-Associated Proteins; Motor Activity; NAD(P)H Dehydrogenase (Quinone); Nerve Degeneration; Neuroprotective Agents; Oxidative Stress; Oxidopamine; Oxidoreductases; Protein Deglycase DJ-1; Rats; Rats, Wistar; Substantia Nigra; Time Factors | 2013 |
Conditioned medium from human amniotic epithelial cells may induce the differentiation of human umbilical cord blood mesenchymal stem cells into dopaminergic neuron-like cells.
Topics: Amnion; Analysis of Variance; Animals; Apomorphine; Brain-Derived Neurotrophic Factor; Cell Differentiation; Culture Media, Conditioned; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Dopaminergic Neurons; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Fetal Blood; Fetus; Flow Cytometry; Homeodomain Proteins; Humans; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Nuclear Receptor Subfamily 4, Group A, Member 2; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Receptor, trkA; Receptor, trkB; RNA, Messenger; Stereotyped Behavior; Transcription Factors; Tyrosine 3-Monooxygenase | 2013 |
Exercise-induced rescue of tongue function without striatal dopamine sparing in a rat neurotoxin model of Parkinson disease.
Topics: Analysis of Variance; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine; Electric Stimulation; Forelimb; Functional Laterality; Hypoglossal Nerve; Male; Movement; Muscle Strength; Neurotoxins; Oxidopamine; Parkinson Disease; Physical Conditioning, Animal; Rats; Rats, Inbred F344; Time Factors; Tongue; Tongue Diseases; Tyrosine 3-Monooxygenase | 2013 |
Transplantation of melanocytes obtained from the skin ameliorates apomorphine-induced abnormal behavior in rodent hemi-parkinsonian models.
Topics: Analysis of Variance; Animals; Apomorphine; Corpus Striatum; Dopamine; Immunohistochemistry; Levodopa; Melanocytes; Mice; Monophenol Monooxygenase; Movement; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Rotation | 2013 |
Neuroprotective effect of hydroxysafflor yellow A on 6-hydroxydopamine-induced Parkinson's disease in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Behavior, Animal; Chalcone; Gene Expression Regulation, Enzymologic; Homovanillic Acid; Male; Neostriatum; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Quinones; Rats; Rats, Sprague-Dawley; Rotation; Substantia Nigra; Tyrosine 3-Monooxygenase | 2013 |
Mapping and kinetics of microglia/neuron cell-to-cell contacts in the 6-OHDA murine model of Parkinson's disease.
Topics: Adaptor Proteins, Signal Transducing; Adrenergic Agents; Animals; Antigens, Differentiation; Apomorphine; Cell Communication; Cell Count; Disease Models, Animal; Dopamine Agonists; Female; Green Fluorescent Proteins; Imaging, Three-Dimensional; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Microscopy, Confocal; Neurons; Oxidopamine; Parkinson Disease; Receptors, Interleukin-8A; Rotation; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase | 2013 |
Microglial cells are involved in the susceptibility of NADPH oxidase knockout mice to 6-hydroxy-dopamine-induced neurodegeneration.
Topics: Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopaminergic Neurons; Inflammation; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Minocycline; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; NADPH Oxidase 2; NADPH Oxidases; Nerve Degeneration; NF-kappa B; Oxidopamine; Parkinson Disease; Substantia Nigra; Tumor Necrosis Factor-alpha | 2013 |
The theta-related firing activity of parvalbumin-positive neurons in the medial septum-diagonal band of Broca complex and their response to 5-HT1A receptor stimulation in a rat model of Parkinson's disease.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; Apomorphine; Desipramine; Diagonal Band of Broca; Male; Neurons; Oxidopamine; Parkinsonian Disorders; Parvalbumins; Piperazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Substantia Nigra; Theta Rhythm | 2014 |
Forced exercise before or after induction of 6-OHDA-mediated nigrostriatal insult does not mitigate behavioral asymmetry in a hemiparkinsonian rat model.
Topics: Adrenergic Agents; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Forelimb; Functional Laterality; Male; Oxidopamine; Parkinsonian Disorders; Physical Conditioning, Animal; Psychomotor Performance; Rats; Rats, Long-Evans; Stereotyped Behavior; Substantia Nigra | 2014 |
Chronic L-DOPA treatment attenuates behavioral and biochemical deficits induced by unilateral lactacystin administration into the rat substantia nigra.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcysteine; Adrenergic Agents; Animals; Antiparkinson Agents; Apomorphine; Catalepsy; Cysteine Proteinase Inhibitors; Dopamine Agonists; Dose-Response Relationship, Drug; Functional Laterality; Levodopa; Male; Oxidopamine; Rats; Rats, Wistar; Reaction Time; Serotonin; Substantia Nigra | 2014 |
NADPH oxidase and the degeneration of dopaminergic neurons in parkinsonian mice.
Topics: Animals; Apomorphine; CD11b Antigen; Dopaminergic Neurons; Enzyme Activation; Glial Fibrillary Acidic Protein; Immunohistochemistry; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; NADPH Oxidase 2; NADPH Oxidases; Neostriatum; Nerve Degeneration; Oxidopamine; Parkinson Disease; Substantia Nigra; Tyrosine 3-Monooxygenase | 2013 |
Squamosamide derivative FLZ protected dopaminergic neuron by activating Akt signaling pathway in 6-OHDA-induced in vivo and in vitro Parkinson's disease models.
Topics: alpha-Synuclein; Animals; Apomorphine; Benzeneacetamides; Cell Death; Disease Models, Animal; Dopamine Agonists; Dopaminergic Neurons; Male; Motor Activity; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Phenols; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Repressor Proteins; Signal Transduction; Transcription Factors; Tyrosine 3-Monooxygenase | 2014 |
Serum melatonin is an alternative index of Parkinson's disease severity.
Topics: Aged; Aged, 80 and over; Animals; Apomorphine; Biomarkers; Dopamine Agonists; Female; Humans; Male; Melatonin; Middle Aged; Motor Activity; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Time Factors | 2014 |
Caffeine neuroprotective effects on 6-OHDA-lesioned rats are mediated by several factors, including pro-inflammatory cytokines and histone deacetylase inhibitions.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Agents; Animals; Apomorphine; Brain; Caffeine; Cytokines; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Exploratory Behavior; Histone Deacetylases; Male; Motor Activity; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar; Tyrosine 3-Monooxygenase | 2014 |
The effects of unilateral 6-OHDA lesion in medial forebrain bundle on the motor, cognitive dysfunctions and vulnerability of different striatal interneuron types in rats.
Topics: Adrenergic Agents; Animals; Apomorphine; Choline O-Acetyltransferase; Cognition Disorders; Corpus Striatum; Creatine; Interneurons; Male; Maze Learning; Medial Forebrain Bundle; Movement Disorders; Muscle Strength; Neuropeptide Y; Oxidopamine; Parvalbumins; Rats; Rats, Sprague-Dawley; Spatial Behavior; Tyrosine 3-Monooxygenase | 2014 |
Noradrenaline neuron degeneration contributes to motor impairments and development of L-DOPA-induced dyskinesia in a rat model of Parkinson's disease.
Topics: Adrenergic Agents; Adrenergic Neurons; Amphetamine; Animals; Antiparkinson Agents; Apomorphine; Benzylamines; Disease Models, Animal; Dyskinesia, Drug-Induced; Female; Levodopa; Motor Activity; Nerve Degeneration; Oxidopamine; Parkinson Disease; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Ribosome Inactivating Proteins, Type 1; Saporins; Stereotyped Behavior | 2014 |
Two-step grafting significantly enhances the survival of foetal dopaminergic transplants and induces graft-derived vascularisation in a 6-OHDA model of Parkinson's disease.
Topics: Adrenergic Agents; Animals; Apomorphine; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Embryo, Mammalian; Female; Fetal Tissue Transplantation; Graft Survival; Green Fluorescent Proteins; Medial Forebrain Bundle; Nerve Fibers; Oxidopamine; Parkinson Disease; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Rats, Transgenic; Time Factors | 2014 |
Intranasally-administered deferoxamine mitigates toxicity of 6-OHDA in a rat model of Parkinson׳s disease.
Topics: Administration, Intranasal; Animals; Antiparkinson Agents; Apomorphine; Deferoxamine; Dopamine Agonists; Dopaminergic Neurons; Functional Laterality; Male; Medial Forebrain Bundle; Motor Activity; Oxidopamine; Parkinsonian Disorders; Photomicrography; Rats, Long-Evans; Substantia Nigra; Tyrosine 3-Monooxygenase | 2014 |
PEGylated rhFGF-2 conveys long-term neuroprotection and improves neuronal function in a rat model of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Apoptosis; Astrocytes; Behavior, Animal; Biological Availability; Cell Survival; Disease Models, Animal; Dopaminergic Neurons; Fibroblast Growth Factor 2; Glial Fibrillary Acidic Protein; Male; Neostriatum; Neuroprotective Agents; Oxidopamine; Parkinson Disease; PC12 Cells; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Substantia Nigra; Tyrosine 3-Monooxygenase | 2015 |
Regenerative therapy in experimental parkinsonism: mixed population of differentiated mouse embryonic stem cells, rather than magnetically sorted and enriched dopaminergic cells provide neuroprotection.
Topics: Adrenergic Agents; Amphetamine; Animals; Apomorphine; Brain; Cell Differentiation; Disease Models, Animal; Dopamine; Embryonic Stem Cells; Functional Laterality; Magnetics; Male; Medial Forebrain Bundle; Nerve Tissue Proteins; Neurons; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Stem Cell Transplantation | 2014 |
Continuous stimulation of the pedunculopontine tegmental nucleus at 40 Hz affects preparative and executive control in a delayed sensorimotor task and reduces rotational movements induced by apomorphine in the 6-OHDA parkinsonian rat.
Topics: Animals; Apomorphine; Deep Brain Stimulation; Disease Models, Animal; Dopamine Agonists; Executive Function; Male; Movement; Oxidopamine; Parkinsonian Disorders; Pedunculopontine Tegmental Nucleus; Psychomotor Performance; Rats; Rats, Wistar; Reaction Time; Treatment Outcome | 2014 |
Rho kinase inhibition by fasudil in the striatal 6-hydroxydopamine lesion mouse model of Parkinson disease.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic Agents; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Proteins; Male; Mice; Mice, Inbred C57BL; Motor Activity; Muscle Strength; Oxidopamine; Parkinson Disease; Protein Kinase Inhibitors; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase | 2014 |
[Protective effect of alkaloids from Piper longum in rat dopaminergic neuron injury of 6-OHDA-induced Parkinson's disease].
Topics: Administration, Oral; Alkaloids; Animals; Apomorphine; Catalase; Dopamine Agonists; Dopaminergic Neurons; Glutathione; Glutathione Peroxidase; Male; Malondialdehyde; Motor Activity; Neostriatum; Nitric Oxide; Nitric Oxide Synthase; Oxidopamine; Parkinson Disease, Secondary; Piper; Random Allocation; Rats; Rats, Sprague-Dawley; Substantia Nigra; Superoxide Dismutase; Tyrosine 3-Monooxygenase | 2014 |
The neuroprotective potential of sinapic acid in the 6-hydroxydopamine-induced hemi-parkinsonian rat.
Topics: Animals; Antioxidants; Apomorphine; Cell Count; Coumaric Acids; Dopaminergic Neurons; Iron; Lipid Peroxidation; Male; Mesencephalon; Nerve Tissue Proteins; Neuroprotective Agents; Nitrites; Oxidopamine; Parkinsonian Disorders; Phytotherapy; Random Allocation; Rats; Rats, Wistar; Stereotyped Behavior; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Tyrosine 3-Monooxygenase | 2015 |
Place conditioning to apomorphine in rat models of Parkinson's disease: differences by dose and side-effect expression.
Topics: Adrenergic Agents; Analysis of Variance; Animals; Apomorphine; Conditioning, Operant; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Functional Laterality; Male; Medial Forebrain Bundle; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotation; Stereotyped Behavior; Tyrosine 3-Monooxygenase | 2014 |
A potential target for the treatment of Parkinson's disease: effect of lateral habenula lesions.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Agents; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agonists; Habenula; Homovanillic Acid; Male; Medial Forebrain Bundle; Neurosurgery; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Tyrosine 3-Monooxygenase | 2014 |
Neuroprotection by 6-(methylsulfinyl)hexyl isothiocyanate in a 6-hydroxydopamine mouse model of Parkinson׳s disease.
Topics: Animals; Apomorphine; Apoptosis; Disease Models, Animal; Dopamine Agonists; Dopaminergic Neurons; Glutathione Reductase; Glutathione Transferase; Isothiocyanates; Male; Mice; Mice, Inbred C57BL; Motor Activity; Neostriatum; Neuroprotective Agents; Oxidative Stress; Oxidopamine; Parkinson Disease; Rotarod Performance Test; Rotation; Substantia Nigra; Tyrosine 3-Monooxygenase | 2014 |
A rat model of striatonigral degeneration generated by simultaneous injection of 6-hydroxydopamine into the medial forebrain bundle and quinolinic acid into the striatum.
Topics: Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Glucose; Injections, Intraperitoneal; Levodopa; Male; Medial Forebrain Bundle; Oxidopamine; Parkinson Disease; Positron-Emission Tomography; Quinolinic Acid; Rats; Rats, Wistar; Striatonigral Degeneration; Touch | 2014 |
Therapeutic effects of GM1 on Parkinson's disease in rats and its mechanism.
Topics: Adrenergic Agents; Animals; Antiparkinson Agents; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Female; G(M1) Ganglioside; Gene Expression Regulation; Interleukin 1 Receptor Antagonist Protein; Interleukin-1beta; Male; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar; RNA, Messenger; Stereotyped Behavior | 2016 |
Activation of serotonin(2C) receptors in the lateral habenular nucleus increases the expression of depression-related behaviors in the hemiparkinsonian rat.
Topics: Action Potentials; Adrenergic Agents; Animals; Apomorphine; Depression; Disease Models, Animal; Dopamine Agonists; Exploratory Behavior; Food Preferences; Functional Laterality; Habenula; Male; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Serotonin Agents; Substantia Nigra; Sucrose; Swimming | 2015 |
Monoaminergic PET imaging and histopathological correlation in unilateral and bilateral 6-hydroxydopamine lesioned rat models of Parkinson's disease: a longitudinal in-vivo study.
Topics: Adrenergic Agents; Animals; Apomorphine; Brain; Carbon Radioisotopes; Disease Models, Animal; Dopamine Agonists; Dopamine Plasma Membrane Transport Proteins; Functional Laterality; Longitudinal Studies; Magnetic Resonance Imaging; Oxidopamine; Parkinson Disease; Positron-Emission Tomography; Protein Binding; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Tetrabenazine | 2015 |
The 6-OHDA mouse model of Parkinson's disease - Terminal striatal lesions provide a superior measure of neuronal loss and replacement than median forebrain bundle lesions.
Topics: Animals; Apomorphine; Corpus Striatum; Dextroamphetamine; Dopamine Agonists; Dopamine Uptake Inhibitors; Dopaminergic Neurons; Dose-Response Relationship, Drug; Embryonic Stem Cells; Female; Medial Forebrain Bundle; Mice, 129 Strain; Motor Activity; Oxidopamine; Parkinsonian Disorders; Rotation | 2015 |
Coadministration of hydroxysafflor yellow A with levodopa attenuates the dyskinesia.
Topics: Adrenergic Agents; Analysis of Variance; Animals; Antiparkinson Agents; Apomorphine; Chalcone; Disease Models, Animal; Levodopa; Male; Motor Activity; Olfaction Disorders; Oxidopamine; Parkinson Disease; Quinones; Rats; Receptors, Dopamine D3; Time Factors | 2015 |
PET Imaging of Serotonin Transporters With 4-[(18)F]-ADAM in a Parkinsonian Rat Model With Porcine Neural Xenografts.
Topics: Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Male; Nerve Degeneration; Oxidopamine; Parkinson Disease; Positron-Emission Tomography; Rats, Sprague-Dawley; Serotonin Plasma Membrane Transport Proteins; Substantia Nigra; Swine; Transplantation, Heterologous | 2016 |
Intranigral administration of substance P receptor antagonist attenuated levodopa-induced dyskinesia in a rat model of Parkinson's disease.
Topics: Adrenergic Agents; Animals; Antiparkinson Agents; Apomorphine; Disease Models, Animal; Dopamine; Dopamine Agonists; Drug Administration Schedule; Dyskinesia, Drug-Induced; Gene Expression Regulation; Indoles; Levodopa; Male; MAP Kinase Signaling System; Motor Activity; Neurokinin-1 Receptor Antagonists; Oxidopamine; Parkinson Disease; Piperidines; Rats; Rats, Sprague-Dawley; Substantia Nigra; Time Factors | 2015 |
Relationships among rat ultrasonic vocalizations, behavioral measures of striatal dopamine loss, and striatal tyrosine hydroxylase immunoreactivity at acute and chronic time points following unilateral 6-hydroxydopamine-induced dopamine depletion.
Topics: Acute Disease; Animals; Apomorphine; Chronic Disease; Corpus Striatum; Dopamine; Dopamine Agonists; Forelimb; Functional Laterality; Male; Medial Forebrain Bundle; Motor Activity; Oxidopamine; Parkinsonian Disorders; Random Allocation; Rats, Long-Evans; Severity of Illness Index; Tyrosine 3-Monooxygenase; Ultrasonics; Vocalization, Animal | 2015 |
Beneficial effects of sodium butyrate in 6-OHDA induced neurotoxicity and behavioral abnormalities: Modulation of histone deacetylase activity.
Topics: Animals; Antiparkinson Agents; Apomorphine; Brain-Derived Neurotrophic Factor; Butyric Acid; Corpus Striatum; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Hippocampus; Histamine Antagonists; Histone Deacetylases; Male; Motor Activity; Neuroimmunomodulation; Oxidative Stress; Oxidopamine; Parkinsonian Disorders; Rats, Wistar; Tumor Necrosis Factor-alpha | 2015 |
Neuroprotective effect of combined therapy with hyperbaric oxygen and madopar on 6-hydroxydopamine-induced Parkinson's disease in rats.
Topics: Animals; Apomorphine; Benserazide; Combined Modality Therapy; Drug Combinations; Glial Fibrillary Acidic Protein; Glutathione Peroxidase; Hyperbaric Oxygenation; Levodopa; Lipid Peroxidation; Male; Malondialdehyde; Nerve Degeneration; Neuroprotective Agents; Oxidative Stress; Oxidopamine; Parkinson Disease; Proto-Oncogene Proteins c-bcl-2; Rats, Wistar; Stereotyped Behavior; Substantia Nigra; Superoxide Dismutase; Tyrosine 3-Monooxygenase | 2015 |
Tanshinone IIA protects dopaminergic neurons against 6-hydroxydopamine-induced neurotoxicity through miR-153/NF-E2-related factor 2/antioxidant response element signaling pathway.
Topics: Abietanes; Animals; Apomorphine; Apoptosis; Cell Survival; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Gene Expression Regulation; Glutathione; Humans; Male; Mice; Mice, Inbred C57BL; Neuroblastoma; Neuroprotective Agents; Neurotoxicity Syndromes; NF-E2-Related Factor 2; Oxidopamine; Reactive Oxygen Species; Signal Transduction; Stereotyped Behavior; Time Factors; Tyrosine 3-Monooxygenase | 2015 |
Hypericum Perforatum Hydroalcoholic Extract Mitigates Motor Dysfunction and is Neuroprotective in Intrastriatal 6-Hydroxydopamine Rat Model of Parkinson's Disease.
Topics: Animals; Apomorphine; Catalase; Corpus Striatum; Disease Models, Animal; Ethanol; Glutathione; Hypericum; Male; Malondialdehyde; Mitogen-Activated Protein Kinases; Motor Activity; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Plant Extracts; Rats, Wistar; Reaction Time; Tumor Necrosis Factor-alpha; Tyrosine 3-Monooxygenase; Water | 2016 |
Intracarotid Infusion of Mesenchymal Stem Cells in an Animal Model of Parkinson's Disease, Focusing on Cell Distribution and Neuroprotective and Behavioral Effects.
Topics: Animals; Apomorphine; Behavior, Animal; Blood-Brain Barrier; Carotid Arteries; Cell Count; Cell Tracking; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Injections, Intra-Arterial; Injections, Intraventricular; Male; Mannitol; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Neurons; Osmolar Concentration; Oxidopamine; Parkinson Disease, Secondary; Permeability; Rats; Rats, Wistar | 2015 |
Antagonism of quercetin against tremor induced by unilateral striatal lesion of 6-OHDA in rats.
Topics: Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Male; Molecular Structure; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Quercetin; Rats; Rats, Sprague-Dawley; Tremor | 2016 |
The preferential nNOS inhibitor 7-nitroindazole and the non-selective one N(G)-nitro-L-arginine methyl ester administered alone or jointly with L-DOPA differentially affect motor behavior and monoamine metabolism in sham-operated and 6-OHDA-lesioned rats.
Topics: Adrenergic Agents; Animals; Apomorphine; Biogenic Monoamines; Brain; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Interactions; Indazoles; Levodopa; Locomotion; Male; Movement Disorders; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Oxidopamine; Rats; Rats, Wistar; Time Factors | 2015 |
Duration of drug action of dopamine D2 agonists in mice with 6-hydroxydopamine-induced lesions.
Topics: Animals; Antiparkinson Agents; Apomorphine; Azepines; Benzothiazoles; Cabergoline; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Ergolines; Indoles; Injections, Intraventricular; Male; Mice; Motor Activity; Oxidopamine; Parkinsonian Disorders; Pramipexole; Quinolines; Receptors, Dopamine D2; Tetrahydronaphthalenes; Thiophenes | 2015 |
Intracranial application of near-infrared light in a hemi-parkinsonian rat model: the impact on behavior and cell survival.
Topics: Animals; Apomorphine; Cell Survival; Dopamine Agonists; Dopaminergic Neurons; Dose-Response Relationship, Radiation; Feasibility Studies; Immunohistochemistry; Low-Level Light Therapy; Male; Mesencephalon; Movement; Optical Fibers; Oxidopamine; Parkinsonian Disorders; Phototherapy; Prostheses and Implants; Rats, Wistar; Tyrosine 3-Monooxygenase | 2016 |
CART modulates the effects of levodopa in rat model of Parkinson's disease.
Topics: Animals; Antibodies; Antiparkinson Agents; Apomorphine; Brain; Dopamine Agonists; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Levodopa; Male; Movement; Nerve Tissue Proteins; Neurons; Oxidopamine; Parkinsonian Disorders; Rats, Sprague-Dawley; Rotarod Performance Test; Tyrosine 3-Monooxygenase | 2016 |
[THYMIC HORMONES, ANTIOXIDANT ENZYMES AND NEUROGENESIS OF BULBUS OLFACTORIUS IN RATS WITH PARKINSONISM: THE EFFECT OF MELATONIN].
Topics: Animals; Antioxidants; Apomorphine; Ataxia; Catalase; Cell Count; Cell Differentiation; Dopamine Agonists; Gene Expression; Glutathione Peroxidase; Male; Melatonin; Nestin; Neural Stem Cells; Neuroprotective Agents; Olfactory Bulb; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Wistar; Superoxide Dismutase; Thymic Factor, Circulating; Thymus Gland | 2015 |
Vocal training, levodopa, and environment effects on ultrasonic vocalizations in a rat neurotoxin model of Parkinson disease.
Topics: Animals; Antiparkinson Agents; Apomorphine; Carbidopa; Communication Disorders; Disease Models, Animal; Dopamine; Dopamine Agonists; Drug Combinations; Fourier Analysis; Levodopa; Male; Neurotoxins; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Long-Evans; Stereotyped Behavior; Time Factors; Ultrasonics; Vocalization, Animal | 2016 |
Pretreatment with potassium channel blockers of 4-aminopyridine and tetraethylammonium attenuates behavioural symptoms of Parkinsonism induced by intrastriatal injection of 6-hydroxydopamine; the role of lipid peroxidation.
Topics: 4-Aminopyridine; Adrenergic Agents; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Functional Laterality; Male; Mental Disorders; Motor Activity; Oxidopamine; Parkinsonian Disorders; Postural Balance; Potassium Channel Blockers; Rats; Rats, Wistar; Tetraethylammonium; Thiazolidinediones | 2016 |
Characterization of liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, in rat partial and full nigral 6-hydroxydopamine lesion models of Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Apomorphine; Body Weight; Disease Models, Animal; Dopamine; Dopamine Agonists; Dopaminergic Neurons; Glucagon-Like Peptide-1 Receptor; Liraglutide; Male; Motor Activity; Neuroprotective Agents; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Substantia Nigra; Tyrosine 3-Monooxygenase | 2016 |
Dramatic differences in susceptibility to l-DOPA-induced dyskinesia between mice that are aged before or after a nigrostriatal dopamine lesion.
Topics: Aging; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine; Dyskinesia, Drug-Induced; Levodopa; Mice, Inbred C57BL; Motor Activity; Oxidopamine; Parkinson Disease | 2016 |
Development and Antiparkinsonian Activity of VU0418506, a Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor 4 Homomers without Activity at mGlu2/4 Heteromers.
Topics: Allosteric Regulation; Animals; Antiparkinson Agents; Antipsychotic Agents; Apomorphine; Brain; Catalepsy; Disease Models, Animal; Dopamine Agonists; Forelimb; Glutamic Acid; Haloperidol; HEK293 Cells; Humans; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Transfection | 2016 |
Characterization of gray matter atrophy following 6-hydroxydopamine lesion of the nigrostriatal system.
Topics: Animals; Apomorphine; Atrophy; Brain; Dopamine Agonists; Dopaminergic Neurons; Functional Laterality; Gray Matter; Immunohistochemistry; Magnetic Resonance Imaging; Male; Motor Activity; Neural Pathways; Oxidopamine; Parkinsonian Disorders; Rats, Sprague-Dawley; Tyrosine 3-Monooxygenase | 2016 |
Altered melatonin MT
Topics: Animals; Apomorphine; Blotting, Western; Corpus Striatum; Dopamine Agonists; Dopaminergic Neurons; Fluorescent Antibody Technique; Male; Medial Forebrain Bundle; Motor Activity; Oxidopamine; Parkinsonian Disorders; Polymerase Chain Reaction; Random Allocation; Rats, Sprague-Dawley; Receptor, Melatonin, MT1; RNA, Messenger; Substantia Nigra; Tyrosine 3-Monooxygenase | 2016 |
The significance of rotational behavior and sensitivity of striatal dopamine receptors in hemiparkinsonian rats: A comparative study of lactacystin and 6-OHDA.
Topics: Acetylcysteine; Amphetamine; Animals; Apomorphine; Benzazepines; Central Nervous System Stimulants; Corpus Striatum; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Functional Laterality; Male; Motor Activity; Oxidopamine; Parkinsonian Disorders; Pars Compacta; Raclopride; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Rotation | 2017 |
Impact of the Chronic Omega-3 Fatty Acids Supplementation in Hemiparkinsonism Model Induced by 6-Hydroxydopamine in Rats.
Topics: Animals; Apomorphine; Biogenic Monoamines; Brain; Dietary Supplements; Disease Models, Animal; Fatty Acids, Omega-3; gamma-Aminobutyric Acid; Lipid Peroxidation; Male; Motor Activity; Nitrites; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar | 2017 |
Blockade of fast A-type and TEA-sensitive potassium channels provide an antiparkinsonian effect in a 6-OHDA animal model.
Topics: 4-Aminopyridine; Animals; Antiparkinson Agents; Apomorphine; Dose-Response Relationship, Drug; Drug Synergism; Male; Malondialdehyde; Medial Forebrain Bundle; Neuroprotective Agents; Oxidopamine; Parkinson Disease, Secondary; Potassium Channel Blockers; Rats; Rotarod Performance Test; Tetraethylammonium | 2017 |
Involvement of lateral habenula α1 subunit-containing GABA
Topics: Action Potentials; Animals; Apomorphine; Depression; Dopamine Agonists; GABA Antagonists; GABA-A Receptor Agonists; Habenula; Male; Muscimol; Neural Inhibition; Neurons; Oxidopamine; Parkinsonian Disorders; Picrotoxin; Prefrontal Cortex; Rats, Sprague-Dawley; Receptors, GABA-A; Serotonin | 2017 |
URB597 reduces biochemical, behavioral and morphological alterations in two neurotoxic models in rats.
Topics: Amidohydrolases; Animals; Apomorphine; Behavior, Animal; Benzamides; Body Weight; Carbamates; Injections; Lipid Peroxidation; Male; Motor Skills; Neostriatum; Neuroprotective Agents; Neurotoxicity Syndromes; Nitro Compounds; Oxidopamine; Propionates; Rats; Rats, Wistar | 2017 |
Dissociation between dopaminergic response and motor behavior following intrastriatal, but not intravenous, transplant of bone marrow mononuclear stem cells in a mouse model of Parkinson's disease.
Topics: Administration, Intravenous; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Dopaminergic Neurons; Green Fluorescent Proteins; Male; Medial Forebrain Bundle; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice, Inbred C57BL; Motor Activity; Oxidopamine; Parkinson Disease; Rotarod Performance Test; Substantia Nigra | 2017 |
Acetyl-l-carnitine protects dopaminergic nigrostriatal pathway in 6-hydroxydopamine-induced model of Parkinson's disease in the rat.
Topics: Acetylcarnitine; Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Dopamine Agonists; Dopaminergic Neurons; Inflammation; Male; Neural Pathways; Nootropic Agents; Oxidative Stress; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Wistar; Substantia Nigra; Sympatholytics | 2017 |
Comparative assessment of 6-[
Topics: Animals; Apomorphine; Aromatic-L-Amino-Acid Decarboxylases; Dihydroxyphenylalanine; Disease Models, Animal; Dopamine; Fluorine Radioisotopes; Image Processing, Computer-Assisted; Male; Neostriatum; Oxidopamine; Parkinson Disease; Parkinson Disease, Secondary; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptors, Presynaptic; Stereotyped Behavior; Tyrosine | 2017 |
Time course study of fractional anisotropy in the substantia nigra of a parkinsonian rat model induced by 6-OHDA.
Topics: Animals; Apomorphine; Diffusion Tensor Imaging; Disease Progression; Dopamine Agonists; Gliosis; Immunohistochemistry; Magnetic Resonance Imaging; Male; Motor Activity; Neurons; Oxidopamine; Parkinsonian Disorders; Rats, Sprague-Dawley; Substantia Nigra; Tyrosine 3-Monooxygenase | 2017 |
Morphological dendritic spine changes of medium spiny neurons in the nucleus accumbens in 6-hydroxydopamine-lesioned rats treated with levodopa.
Topics: Animals; Apomorphine; Dendritic Spines; Disease Models, Animal; Dopamine Agents; Levodopa; Male; Medial Forebrain Bundle; Neurons; Nucleus Accumbens; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Wistar; Statistics, Nonparametric; Sympatholytics; Time Factors; Tyrosine 3-Monooxygenase | 2017 |
Altered somatosensory cortex neuronal activity in a rat model of Parkinson's disease and levodopa-induced dyskinesias.
Topics: Action Potentials; Animals; Antiparkinson Agents; Apomorphine; Disease Models, Animal; Dyskinesia, Drug-Induced; Female; Glutamate Decarboxylase; Levodopa; Motor Cortex; Nerve Tissue Proteins; Neurons; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Receptors, GABA; RNA, Messenger; Sympatholytics; Tandem Mass Spectrometry | 2017 |
Efficacy of oral lipid-based formulations of apomorphine and its diester in a Parkinson's disease rat model.
Topics: Administration, Oral; Animals; Apomorphine; Chemistry, Pharmaceutical; Delayed-Action Preparations; Dopamine Agonists; Drug Compounding; Drug Delivery Systems; Drug Liberation; Emulsions; Esters; Half-Life; Lipids; Male; Oxidopamine; Parkinsonian Disorders; Prodrugs; Rats; Rats, Sprague-Dawley | 2017 |
The effect of electroacupuncture on proteomic changes in the motor cortex of 6-OHDA Parkinsonian rats.
Topics: Animals; Apomorphine; Blotting, Western; Chromatography, High Pressure Liquid; Dopamine Agonists; Electroacupuncture; Immunohistochemistry; Male; Mass Spectrometry; Medial Forebrain Bundle; Motor Activity; Motor Cortex; Oxidopamine; Parkinsonian Disorders; Proteome; Proteomics; Random Allocation; Rats, Sprague-Dawley; Tyrosine 3-Monooxygenase | 2017 |
Alpha Lipoamide Ameliorates Motor Deficits and Mitochondrial Dynamics in the Parkinson's Disease Model Induced by 6-Hydroxydopamine.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Apomorphine; Cell Death; Disease Models, Animal; Dopamine Agonists; Dopaminergic Neurons; Exploratory Behavior; Forelimb; Male; Mesencephalon; Microscopy, Electron, Transmission; Mitochondria; Mitochondrial Dynamics; Mitochondrial Proteins; Motor Activity; Motor Disorders; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Sympatholytics; Thioctic Acid | 2018 |
Effect of varenicline on behavioral deficits in a rat model of Parkinson's disease induced by unilateral 6-hydroxydopamine lesion of substantia nigra.
Topics: Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Dopamine; Male; Motor Activity; Nicotinic Agonists; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Substantia Nigra; Varenicline | 2018 |
Differential effects of dopaminergic drugs on spontaneous motor activity in the common marmoset following pretreatment with a bilateral brain infusion of 6-hydroxydopamine.
Topics: Animals; Apomorphine; Area Under Curve; Callithrix; Corpus Striatum; Disease Models, Animal; Dopamine Agents; Dopaminergic Neurons; Dose-Response Relationship, Drug; Immunohistochemistry; Levodopa; Male; Methamphetamine; Motor Activity; Oxidopamine; Parkinsonian Disorders; Substantia Nigra; Tyrosine 3-Monooxygenase | 2017 |
The Kv7/KCNQ channel blocker XE991 protects nigral dopaminergic neurons in the 6-hydroxydopamine rat model of Parkinson's disease.
Topics: Animals; Anthracenes; Apomorphine; Corpus Striatum; Dopamine; Dopamine Agonists; Dopaminergic Neurons; Infusions, Intraventricular; KCNQ Potassium Channels; Male; Motor Activity; Muscle Rigidity; Neuroprotective Agents; Oxidopamine; Parkinsonian Disorders; Potassium Channel Blockers; Rats, Wistar; Substantia Nigra | 2018 |
Involvement of adenosine triphosphate-sensitive potassium channels in the neuroprotective activity of hydrogen sulfide in the 6-hydroxydopamine-induced animal model of Parkinson's disease.
Topics: Adenosine Triphosphate; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agonists; Hydrogen Sulfide; KATP Channels; Male; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Oxidative Stress; Oxidopamine; Parkinson Disease; Potassium Channels; Rats; Rats, Wistar; Substantia Nigra | 2018 |
Combination of CDNF and Deep Brain Stimulation Decreases Neurological Deficits in Late-stage Model Parkinson's Disease.
Topics: Animals; Antiparkinson Agents; Apomorphine; Combined Modality Therapy; Corpus Striatum; Deep Brain Stimulation; Disease Progression; Dopamine Agonists; Humans; Male; Motor Activity; Nerve Growth Factors; Oxidopamine; Parkinsonian Disorders; Rats, Wistar; Recombinant Proteins; Tyrosine 3-Monooxygenase | 2018 |
Pirouetting pigs: A large non-primate animal model based on unilateral 6-hydroxydopamine lesioning of the nigrostriatal pathway.
Topics: Amphetamine; Animals; Apomorphine; Biophysics; Central Nervous System Stimulants; Corpus Striatum; Deep Brain Stimulation; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Functional Laterality; Magnetic Resonance Imaging; Neural Pathways; Oxidopamine; Parkinsonian Disorders; Substantia Nigra; Swine; Swine, Miniature; Sympatholytics; Tyrosine 3-Monooxygenase | 2018 |
Analysis of respiratory movements in a mouse model of late Parkinson's disease submitted to stress.
Topics: Animals; Apomorphine; Cineradiography; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Locomotion; Male; Mice; Mice, Inbred C57BL; Motor Activity; Oxidopamine; Parkinson Disease, Secondary; Respiration; Stress, Physiological; Sympatholytics | 2018 |
Electroacupuncture Alleviates Motor Symptoms and Up-Regulates Vesicular Glutamatergic Transporter 1 Expression in the Subthalamic Nucleus in a Unilateral 6-Hydroxydopamine-Lesioned Hemi-Parkinsonian Rat Model.
Topics: Adrenergic Agents; Animals; Apomorphine; Disease Models, Animal; Dopamine Agonists; Electroacupuncture; Functional Laterality; Male; Medial Forebrain Bundle; Motor Activity; Neurons; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Subthalamic Nucleus; Tyrosine 3-Monooxygenase; Up-Regulation; Vesicular Glutamate Transport Protein 1 | 2018 |
Identification of metabolite biomarkers for L-DOPA-induced dyskinesia in a rat model of Parkinson's disease by metabolomic technology.
Topics: Animals; Antiparkinson Agents; Apomorphine; Arachidonic Acids; Biomarkers; Cannabinoid Receptor Agonists; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Dyskinesia, Drug-Induced; Endocannabinoids; Glycerides; Levodopa; Male; Metabolome; Metabolomics; Motor Activity; Oxidopamine; Parkinsonian Disorders; Polyunsaturated Alkamides; Rats, Sprague-Dawley | 2018 |
Changes in the Serum Urate Level Can Predict the Development of Parkinsonism in the 6-Hydroxydopamine Animal Model.
Topics: Animals; Apomorphine; Biomarkers; Cell Death; Dopamine; Dopamine Agonists; Male; Neurons; Oxidative Stress; Oxidopamine; Parkinson Disease, Secondary; Predictive Value of Tests; Rats; Rats, Wistar; Substantia Nigra; Tyrosine 3-Monooxygenase; Uric Acid | 2018 |
Evaluation of the antiparkinsonism and neuroprotective effects of hydrogen sulfide in acute 6-hydroxydopamine-induced animal model of Parkinson's disease: behavioral, histological and biochemical studies.
Topics: Analysis of Variance; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Glutathione Peroxidase; Hydrogen Sulfide; Male; Malondialdehyde; Motor Activity; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Postural Balance; Rats; Rats, Wistar; Rotarod Performance Test; Superoxide Dismutase; Sympatholytics | 2018 |
Feeding-produced subchronic high plasma levels of uric acid improve behavioral dysfunction in 6-hydroxydopamine-induced mouse model of Parkinson's disease.
Topics: Adrenergic Agents; Animals; Apomorphine; Disease Models, Animal; Hyperuricemia; Male; Mental Disorders; Mice; Mice, Inbred ICR; Motor Activity; Oxidopamine; Oxonic Acid; Parkinson Disease, Secondary; Rotarod Performance Test; Tyrosine 3-Monooxygenase; Uric Acid | 2019 |
Protective and therapeutic activity of honokiol in reversing motor deficits and neuronal degeneration in the mouse model of Parkinson's disease.
Topics: Animals; Apomorphine; Biphenyl Compounds; Corpus Striatum; Disease Models, Animal; Lignans; Male; Mice; Microinjections; Motor Activity; Neuroprotective Agents; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Oxidopamine; Parkinson Disease, Secondary; Postural Balance; Substantia Nigra; Tyrosine 3-Monooxygenase | 2018 |
Behavioral and neurochemical responses derived from dopaminergic intrastriatal grafts in hemiparkinsonian rats engaged in a novel motor task.
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Cell Differentiation; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agonists; Functional Laterality; LIM-Homeodomain Proteins; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Microdialysis; Oxidopamine; Parkinson Disease, Secondary; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley; Sympatholytics; Time Factors; Tyrosine 3-Monooxygenase | 2018 |
Involvement of prelimbic 5-HT
Topics: Animals; Anxiety; Apomorphine; Desipramine; Disease Models, Animal; Dopamine Agents; Enzyme Inhibitors; Exploratory Behavior; Functional Laterality; Male; Maze Learning; Oxidopamine; Parkinsonian Disorders; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Serotonin Agents; Sympatholytics | 2018 |
The Protective Role of Brain CYP2J in Parkinson's Disease Models.
Topics: alpha-Synuclein; Animals; Apomorphine; Brain; Cell Line, Tumor; Chromatin Immunoprecipitation; Cytochrome P-450 Enzyme System; Disease Models, Animal; Dopaminergic Neurons; Humans; Lipopolysaccharides; Male; Myeloid Differentiation Factor 88; NF-E2-Related Factor 2; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar; Signal Transduction; Toll-Like Receptor 4 | 2018 |
NOD2 promotes dopaminergic degeneration regulated by NADPH oxidase 2 in 6-hydroxydopamine model of Parkinson's disease.
Topics: Acetophenones; Animals; Apomorphine; Cell Line, Transformed; Corpus Striatum; Disease Models, Animal; Dopamine; Enzyme Inhibitors; Gene Expression Regulation; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidase 2; Nerve Degeneration; Nod2 Signaling Adaptor Protein; Oxidopamine; Parkinson Disease, Secondary; Reactive Oxygen Species | 2018 |
Vitamin D protects dopaminergic neurons against neuroinflammation and oxidative stress in hemiparkinsonian rats.
Topics: Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopaminergic Neurons; Encephalitis; Exploratory Behavior; Lipid Peroxidation; Male; Oxidative Stress; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Stereotyped Behavior; Swimming; Sympatholytics; Tyrosine 3-Monooxygenase; Vitamin D | 2018 |
Expression of magnesium transporter SLC41A1 in the striatum of 6-hydroxydopamine-induced parkinsonian rats.
Topics: Animals; Antiparkinson Agents; Apomorphine; Cation Transport Proteins; Corpus Striatum; Dopamine Agonists; Dopaminergic Neurons; Gene Expression; Magnesium; Magnesium Sulfate; Male; Movement; Oxidopamine; Parkinsonian Disorders; Rats, Sprague-Dawley; RNA, Messenger; Tyrosine 3-Monooxygenase | 2018 |
Nei-like 1 inhibition results in motor dysfunction and promotes inflammation in Parkinson's disease mice model.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apomorphine; Disease Models, Animal; DNA Glycosylases; Inflammation; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Oxidopamine; Parkinson Disease; Stereotaxic Techniques | 2020 |
A protective role for N-acylphosphatidylethanolamine phospholipase D in 6-OHDA-induced neurodegeneration.
Topics: Animals; Apomorphine; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Survival; Corpus Striatum; Dopaminergic Neurons; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidopamine; Phospholipase D; rac1 GTP-Binding Protein; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering | 2019 |
mGluR5 Allosteric Modulation Promotes Neurorecovery in a 6-OHDA-Toxicant Model of Parkinson's Disease.
Topics: Animals; Apomorphine; Disease Models, Animal; Dopaminergic Neurons; Male; Mice; Neurodegenerative Diseases; Oxidopamine; Parkinson Disease; Receptor, Metabotropic Glutamate 5 | 2020 |
L-linalool exerts a neuroprotective action on hemiparkinsonian rats.
Topics: Acyclic Monoterpenes; Animals; Apomorphine; Brain; Disease Models, Animal; Dopamine; Lipid Peroxidation; Male; Motor Activity; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar | 2020 |
C60 fullerenes increase the intensity of rotational movements in non‑anesthetized hemiparkinsonic rats.
Topics: Animals; Antioxidants; Apomorphine; Female; Fullerenes; Motor Activity; Muscle Fatigue; Muscle, Skeletal; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Stereotaxic Techniques | 2020 |
L-DOPA-elicited abnormal involuntary movements in the rats damaged severely in substantia nigra by 6-hydroxydopamine.
Topics: Animals; Apomorphine; Dopamine; Dyskinesia, Drug-Induced; Levodopa; Oxidopamine; Rats; Substantia Nigra | 2020 |
Intrastriatal administration of coenzyme Q10 enhances neuroprotection in a Parkinson's disease rat model.
Topics: Administration, Oral; Animals; Apomorphine; Corpus Striatum; Dopaminergic Neurons; Dose-Response Relationship, Drug; Down-Regulation; Inflammation; Infusion Pumps, Implantable; Infusions, Parenteral; Male; Neovascularization, Physiologic; Neurogenesis; Neuroprotective Agents; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Tyrosine 3-Monooxygenase; Ubiquinone | 2020 |
Erythropoietin modulates striatal antioxidant signalling to reduce neurodegeneration in a toxicant model of Parkinson's disease.
Topics: Animals; Apomorphine; Brain; Cell Shape; Corpus Striatum; Dopamine; Erythropoietin; Humans; Male; Mice; Mice, Inbred C57BL; Microglia; Neuroglia; Neuroprotective Agents; Oxidative Stress; Oxidopamine; Parkinsonian Disorders; Pilot Projects; Recombinant Proteins; Single-Blind Method; Video Recording | 2020 |
Engrafted primary type-2 astrocytes improve the recovery of the nigrostriatal pathway in a rat model of Parkinson's disease.
Topics: Adaptor Proteins, Signal Transducing; Adrenergic Agents; Animals; Apomorphine; Astrocytes; Disease Models, Animal; Dopaminergic Neurons; Male; Motor Activity; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Substantia Nigra | 2021 |
Neuroprotective Effects of Safflower Flavonoid Extract in 6-Hydroxydopamine-Induced Model of Parkinson's Disease May Be Related to its Anti-Inflammatory Action.
Topics: Animals; Anti-Inflammatory Agents; Apomorphine; Apoptosis; Astrocytes; Behavior, Animal; Brain; Carthamus tinctorius; Coculture Techniques; Dopamine; Flavonoids; Inflammasomes; Inflammation; Interleukin-1beta; Maze Learning; Mice; Neurons; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidopamine; Parkinson Disease, Secondary; Plant Extracts; Rats; Substantia Nigra; Tyrosine 3-Monooxygenase | 2020 |
The Effect of Levosimendan on Two Distinct Rodent Models of Parkinson's Disease.
Topics: Animals; Apomorphine; Cardiotonic Agents; Disease Models, Animal; Dopamine; Dopamine Agents; Male; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Rats; Simendan; Substantia Nigra; Sympatholytics | 2020 |
Extract of Polygala tenuifolia, Angelica tenuissima, and Dimocarpus longan Reduces Behavioral Defect and Enhances Autophagy in Experimental Models of Parkinson's Disease.
Topics: Angelica; Animals; Apomorphine; Autophagy; Cell Line, Tumor; Corpus Striatum; Dopaminergic Neurons; Drug Evaluation, Preclinical; Humans; Male; Mice; Mice, Inbred C57BL; Molecular Structure; Neuroblastoma; Neuroprotective Agents; Oxidopamine; Parkinsonian Disorders; Phytotherapy; Plant Extracts; Polygala; Random Allocation; Rats; Rats, Sprague-Dawley; Rotarod Performance Test; Sapindaceae; Saponins; Substantia Nigra; Triterpenes; Tyrosine 3-Monooxygenase | 2021 |
Chronic feeding with 3% dried raw blueberries (V. corymbosum) reduces apomorphine-induced rotations and striatal dopaminergic loss in hemiparkinsonian rats.
Topics: Animals; Apomorphine; Blueberry Plants; Corpus Striatum; Male; Oxidopamine; Rats; Substantia Nigra | 2021 |
Protective effect of caffeine and/or taurine on the 6-hydroxydopamine-induced rat model of Parkinson's disease: Behavioral and neurochemical evidence.
Topics: Animals; Apomorphine; Behavior, Animal; Caffeine; Corpus Striatum; Disease Models, Animal; Dopamine; Oxidopamine; Parkinson Disease; Rats; Taurine | 2021 |
Antidepressant-Like Properties of Intrastriatal Botulinum Neurotoxin-A Injection in a Unilateral 6-OHDA Rat Model of Parkinson's Disease.
Topics: Amphetamine; Animals; Antidepressive Agents; Apomorphine; Behavior, Animal; Botulinum Toxins, Type A; Corpus Striatum; Disease Models, Animal; Injections; Male; Motor Activity; Oxidopamine; Parkinson Disease; Parkinsonian Disorders; Rats; Rats, Wistar | 2021 |
Pycnogenol ameliorates motor function and gene expressions of NF-ƙB and Nrf2 in a 6-hydroxydopamine-induced experimental model of Parkinson's disease in male NMRI mice.
Topics: Animals; Antioxidants; Apomorphine; Dose-Response Relationship, Drug; Flavonoids; Gene Expression Regulation; Male; Mice; Neuroprotective Agents; NF-E2-Related Factor 2; NF-kappa B; Oxidopamine; Parkinsonian Disorders; Plant Extracts | 2022 |
6-Hydroxydopamine-Induced Neurotoxicity in Rat Model of Parkinson's Disease: Is Reversed via Anti-Oxidative Activities of Curcumin and Aerobic Exercise Therapy.
Topics: alpha-Synuclein; Animals; Antioxidants; Apomorphine; Curcumin; Disease Models, Animal; Glutathione Peroxidase; Malondialdehyde; Neuroprotective Agents; Neurotoxicity Syndromes; Neurotoxins; Oxidopamine; Parkinson Disease; Rats; Substantia Nigra | 2022 |
5-(4-Hydroxy-3-dimethoxybenzylidene)-thiazolidinone improves motor functions and exerts antioxidant potential in hemiparkinsonian rats.
Topics: Animals; Antioxidants; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Oxidopamine; Parkinson Disease; Rats; Substantia Nigra; Tyrosine 3-Monooxygenase | 2023 |