apomorphine has been researched along with n-n-propylnorapomorphine in 285 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 153 (53.68) | 18.7374 |
| 1990's | 79 (27.72) | 18.2507 |
| 2000's | 36 (12.63) | 29.6817 |
| 2010's | 16 (5.61) | 24.3611 |
| 2020's | 1 (0.35) | 2.80 |
| Authors | Studies |
|---|---|
| George, SR; Guan, HC; Laurier, LG; Ng, G; Niznik, HB; O'Dowd, BF; Seeman, P; Sunahara, RK; Torchia, J; Van Tol, HH | 1 |
| Riffee, WH; Smith, RV; Wilcox, RE | 2 |
| Benassi-Benelli, A; Ferrari, F; Quarantotti, BP | 1 |
| Seeman, P; Titeler, M | 1 |
| Crumly, HJ; Goldberg, LI; Hinshaw, WB; Pinder, RM | 1 |
| De Boer, T; Florijn, WJ; Tonnaer, JA; Versteeg, DH | 1 |
| Crawford, CA; McDougall, SA; Nonneman, AJ | 1 |
| Bohmaker, K; Bordi, F; Meller, E | 3 |
| Ekman, A; Eriksson, E | 1 |
| Agnati, LF; Carani, C; Cintra, A; Fuxe, K; Li, XM; Merlo Pich, E; O'Connor, WT; Tanganelli, S; Tinner, B; Von Euler, G | 1 |
| Hedlund, PB; Hillefors, M; Janson, AM; von Euler, G | 1 |
| Inoue, O; Itoh, T; Suhara, T; Tsukada, H; Yamasaki, T; Yonezawa, H | 1 |
| Baldessarini, RJ; Bissette, G; Campbell, A; Kilts, CD; Levant, B; Nemeroff, CB | 1 |
| Baldessarini, RJ; Booth, RG; Campbell, A | 1 |
| Baldessarini, RJ; Campbell, A; Neumeyer, JL; Yeghiayan, S | 1 |
| Ferre, S; Fredholm, BB; Fuxe, K; Johansson, B; von Euler, G | 1 |
| Elazar, Z; Fuchs, S | 2 |
| De Boer, T; Florijn, WJ; Tonnaer, JA; Van Nispen, JW; Versteeg, DH | 1 |
| Grol, CJ; Hacksell, U; Johansson, AM; Nordvall, G | 1 |
| Cassinadri, M; Ferrari, F; Tampieri, A; Tartoni, PL | 1 |
| Agerberth, B; Ferré, S; Fuxe, K; Mutt, V; von Euler, G; von Euler, M | 1 |
| Essink, AW; Klein Elhorst, JT; Lohuis, CP; Rutten, WJ | 1 |
| Fredholm, BB; Fuxe, K; van der Ploeg, I; von Euler, G | 1 |
| Ross, SB | 1 |
| Baronti, F; Chase, TN; Conant, K; Davis, TL; Giuffra, M; Heuser, IJ; Mouradian, MM | 1 |
| Bergmeier, S; Caprathe, BW; Heffner, TG; Humblet, CC; Jaen, JC; Meltzer, LT; Pugsley, TA; Tecle, H; Wise, LD | 1 |
| Bouvier, C; Collu, R; Lagacé, G; Potier, M | 1 |
| Barnes, JM; Barnes, NM; Costall, B; Naylor, RJ | 1 |
| Baldessarini, RJ; Booth, RG; Gao, Y; Kula, NS; Neumeyer, JL; Zong, R | 1 |
| De Boer, T; De Vos, CJ; Tonnaer, JA; Van Delft, AM | 1 |
| Baldessarini, RJ; Booth, RG | 1 |
| Loopuijt, LD; Sebens, JB | 1 |
| Eneroth, P; Fuxe, K; Hökfelt, T; Meister, B; von Euler, G | 1 |
| Cox, RF; Waszczak, BL | 3 |
| Barone, D; Benedetti, MS; Dostert, P; Efthymiopoulos, C; Peretti, G; Roncucci, R | 1 |
| Carlsson, A; Fredriksson, K; Grol, CJ; Hacksell, U; Johansson, AM; Sundell, S; Svensson, K | 1 |
| Arnt, J; Hyttel, J | 1 |
| Axton, MS; Moore, NA | 1 |
| Baldessarini, RJ; Gao, YG; Kula, NS; Marsh, ER; Neumeyer, JL; Zong, RS | 1 |
| Heyer, EJ | 1 |
| Fuchs, S; Kanety, H | 1 |
| Agnati, LF; Benfenati, F; Fuxe, K; Gustafsson, JA; Hansson, T; von Euler, G | 1 |
| Loopuijt, LD | 1 |
| Hizami, R; Kreuter, L; Meller, E | 1 |
| Bordi, F; Carr, KD; Meller, E | 1 |
| Elazar, Z; Fuchs, S; Siegel, G | 1 |
| Jackson, DM; Ross, SB | 1 |
| Costall, B; Domeney, AM; Naylor, RJ | 6 |
| George, SR; Seeman, P; Watanabe, M | 2 |
| Fuxe, K; Hökfelt, T; Meister, B; von Euler, G | 1 |
| Allikmets, LKh; Maĭmets, MO; Nurk, AM; Vasar, EE | 1 |
| Claustre, Y; Fage, D; Scatton, B; Zivkovic, B | 1 |
| Agnati, LF; Battistini, N; Benfenati, F; Calza, L; Fuxe, K; Giardino, L; Guidolin, D; Ruggeri, M; Vanderhaeghen, JJ; Zoli, M | 1 |
| Davis, JM; Schaffer, MH; Tamminga, CA | 1 |
| Bhargava, HN; Das, S | 1 |
| Hall, H; Jerning, E; Sällemark, M | 1 |
| Alphs, LD; Foster, NL; Gotts, MD; Tamminga, CA; Thaker, GK | 1 |
| Bohmaker, K; Friedhoff, AJ; Goldstein, M; Meller, E; Namba, Y | 1 |
| Barnes, NJ; Costall, B; Domeney, AM; Naylor, RJ | 1 |
| Bajwa, SB; Johnson, RL; Mishra, RK; Srivastava, LK | 1 |
| Enz, A; Goldstein, M; Meller, E | 1 |
| Allikmets, L; Maimets, M; Nurk, A; Soosaar, A; Vasar, E | 1 |
| Abdel-Maksoud, HM; Davis, PJ; Neumeyer, JL; Trainor, TM; Vouros, P | 1 |
| Grol, CJ; Hacksell, U; Johansson, AM; Karlén, A; Kenne, L; Sundell, S | 1 |
| Curet, O; Dubois, A; Savasta, M; Scatton, B | 1 |
| Andersen, PH; Nielsen, EB | 1 |
| Battaglia, G; Creese, I; Norman, AB | 1 |
| D'Agostini, F; Da Prada, M; Haefely, WE; Pizzi, M; Spano, PF | 1 |
| Lin, C; McGonigle, P; Molinoff, PB | 1 |
| Beauregard, G; Bouvier, C; Collu, R; Lafond, J; Lagacé, G; Potier, M | 1 |
| Arnt, J | 1 |
| Korf, J; Loopuijt, LD; Sebens, JB | 3 |
| Karlsson-Boethius, G; Köhler, C | 1 |
| Martin, JR; Takemori, AE | 1 |
| Ahlijanian, MK; Bier-Laning, CM; Cooper, DM; Halford, MK; Zahniser, NR | 1 |
| Baldessarini, RJ; Campbell, A; Neumeyer, JL; Teicher, MH | 2 |
| Wreggett, KA | 1 |
| Bohmaker, K; Friedhoff, AJ; Goldstein, M; Meller, E; Schweitzer, JW | 1 |
| Grigoriadis, D; Seeman, P | 1 |
| Dubois, A; Scatton, B | 1 |
| Cox, RF; Neumeyer, JL; Waszczak, BL | 1 |
| Baldessarini, RJ; Kula, NS; Lampen, P; Neumeyer, JL; Trainor, TM; Vouros, P | 1 |
| DeWald, HA; Hawkins, ES; Heffner, TG; Meltzer, LT; Pugsley, TA; Reynolds, DM; Wise, LD | 1 |
| Baldessarini, RJ; Lampen, P; Neumeyer, JL | 1 |
| Ferrari, F; Mangiafico, V | 1 |
| Fuxe, K; Von Euler, G | 1 |
| Burke, JA; Potter, DE | 1 |
| Kohjimoto, Y; Kuwaki, T; Nomura, Y; Ono, T; Satoh, H; Shibayama, F; Shirakawa, K | 1 |
| Agnati, LF; Fuxe, K; Gustafsson, JA; Hansson, T; von Euler, G | 1 |
| Camus, A; Dubois, A; Javoy-Agid, F; Scatton, B | 1 |
| Korf, J; Sebens, JB; Van der Werf, JF | 2 |
| Baldessarini, RJ; Froimowitz, M; Neumeyer, JL | 1 |
| Cullen, M; Kazmi, SM; Mishra, RK; Rajakumar, G; Ramwani, J; Ross, GM; Srivastava, LK | 1 |
| Brann, MR; Young, WS | 1 |
| Ozaki, L; Stern, N; Tuck, ML | 1 |
| Gredal, O; Nielsen, M | 1 |
| Blengio, M; Bosco, MC; Eva, C; Ferretti, C; Ghi, P; Portaleone, P | 1 |
| Da Prada, M; Keller, HH | 1 |
| Buchman, O; Grigoriadis, D; Pri-Bar, I; Seeman, P; Ulpian, C | 1 |
| De Vries, JB; Dijkstra, D; Hazelhoff, B; Horn, AS; Mulder, TB | 1 |
| Baggio, G; Ferrari, F | 5 |
| Flentge, F; Korf, J; Sebens, JB; van der Werf, JF | 1 |
| Crooks, PA; Rosenberg, HE; Sommerville, R | 1 |
| Gulat-Marnay, C; Lafitte, A; Protais, P; Schwartz, JC | 1 |
| Fleminger, S; Hall, MD; Jenner, P; Kilpatrick, G; Mann, S; Marsden, CD; Rupniak, NM | 2 |
| Ferrari, F | 1 |
| Boyce, CB; Neumeyer, JL; Neustadt, BR; Oh, KH; Rosenberg, FJ; Teiger, DG; Weinhardt, KK | 1 |
| Costall, B; Lim, SK; Naylor, RJ | 1 |
| Battaglia, G; Titeler, M | 1 |
| Fleminger, S; Hall, MD; Jenner, P; Kerwin, R; Marsden, CD; Murugaiah, K; Rupniak, NM | 1 |
| Fuxe, K; Köhler, C; Ogren, SO | 1 |
| Agnati, LF; Celani, MF; Fuxe, K; Martire, M; Zini, I; Zoli, M | 1 |
| Bendesky, RJ; Martin, GE | 1 |
| Chivers, JK; Hall, MD; Jenner, P; Kelly, E; Marsden, CD | 1 |
| Angeby, K; Florvall, L; Hall, H; Köhler, C; Lindbom, LO; Magnusson, O; Ogren, SO | 1 |
| Agnati, LF; Aldinio, C; Consolazione, A; Fuxe, K; Savoini, G; Toffano, G; Valenti, G | 1 |
| Hall, MD; Jenner, P; Marsden, CD | 2 |
| Kuno, T; Tanaka, C | 1 |
| MacKenzie, RG; Zigmond, MJ | 1 |
| Cools, AR; van Rossum, JM | 1 |
| Arana, GW; Baldessarini, RJ; Campbell, A; Kula, NS; Neumeyer, JL; Ram, VJ; Sperk, G | 1 |
| Agnati, LF; Celani, MF; Fuxe, K | 1 |
| Agnati, LF; Battistini, N; Benfenati, F; Fuxe, K | 1 |
| Agnati, LF; Fuxe, K | 1 |
| Barbeau, A; De Michele, G; Jolicoeur, FB; St-Pierre, S | 1 |
| Korf, J; Sebens, JB; Vaalburg, W; van der Werf, JF | 1 |
| Randall, PK; Severson, JA | 1 |
| Hall, MD; Jenner, P; Kelly, E; Marsden, CD | 1 |
| Hall, MD; Jenner, P; Kilpatrick, G; Marsden, CD; Rupniak, NM | 1 |
| Battaini, F; Govoni, S; Rius, RA; Spano, PF; Trabucchi, M | 1 |
| Caron, MG; Kilpatrick, BF; McDonald, WM; Sibley, DR | 1 |
| Adelung, C; Lang, JD; Späth, L; Starke, K | 1 |
| Caron, MG; Kilpatrick, BF; Sibley, DR | 1 |
| Arana, GW; Baldessarini, RJ; Campbell, A; Kula, NS; Neumeyer, JL; Reischig, D; Watling, KJ | 1 |
| Gudelsky, GA; Meltzer, HY; Mikuni, M; Simonovic, M | 1 |
| Fratta, W; Gessa, GL; Napoli-Farris, L | 1 |
| Fuller, RW; Hemrick-Luecke, SK; Snoddy, HD | 1 |
| Cudennec, A; Dubois, A; Scatton, B | 1 |
| Chen, PC; Hammett, S; Riffee, WH; Smith, RV; Wilcox, RE | 1 |
| Argiolas, A; Fadda, F; Gessa, GL; Melis, MR; Mereu, G; Serra, G | 1 |
| Riffee, WH; Smith, RV; Vaughn, DM; Wilcox, RE | 1 |
| Creese, I; Sibley, DR | 2 |
| Creese, I; Mahan, LC; Sibley, DR | 1 |
| Agnati, LF; Fuxe, K; Goldstein, M; Köhler, C; Lew, JY; Okada, K | 1 |
| Kuttab, SH; Maksoud, HM; Neumeyer, JL; Vouros, P | 1 |
| De Moreno, MR; Smith, RV | 1 |
| Creese, I; Segal, DS; Sibley, DR; Weinberger, S | 1 |
| Baldessarini, RJ; Campbell, A; Neumeyer, JL; Ram, VJ | 1 |
| Baldessarini, RJ; Campbell, A; Neumeyer, JL; Sperk, G; Stoll, A | 1 |
| Argiolas, A; Gessa, GL; Melis, MR; Mereu, G | 1 |
| Leysen, JE; Van Gompel, P | 1 |
| Caron, MG; De Lean, A; Kilpatrick, BF | 3 |
| Costall, B; Hui, SC; Naylor, RJ | 1 |
| Burn, P; Costall, B; Crooks, PA; Heatley, F; Naylor, RJ; Nohria, V | 1 |
| Mahler, HR; Near, JA | 1 |
| Adams, L; Creese, I; Hyttel, J; Leff, S | 1 |
| Stewart, RM | 1 |
| Agnati, LF; Andersson, K; Fuxe, K; Hökfelt, T; Köhler, C; Kuonen, D; Ogren, SO | 1 |
| Fuxe, K; Köhler, C; Ross, SB | 1 |
| Schechter, MD | 1 |
| Senogles, SE | 1 |
| Fuxe, K; Hedlund, PB; Li, XM | 2 |
| Kozell, LB; Neve, KA; Starr, S | 1 |
| Bolanos, CA; McDougall, SA | 1 |
| Bolanos, CA; Crawford, CA; Duke, MA; McDougall, SA | 1 |
| Bhatia, M; Borrelli, E; Ceraline, J; Guiramand, J; Montmayeur, JP | 1 |
| Bruhwyler, J; Damas, J; Delarge, J; Geczy, J; Liégeois, JF; Masereel, B; Rogister, F | 1 |
| Fuxe, K; Hedlund, PB; Janson, AM; von Euler, G | 1 |
| Garrett, BE; Holtzman, SG | 1 |
| Baldessarini, RJ; Ben-Jonathan, N; Campbell, A; Ellingboe, J; Neumeyer, JL; Zong, R | 1 |
| Friedhoff, AJ; Rosengarten, H; Schweitzer, JW | 1 |
| Baldessarini, RJ; Campbell, A; Neumeyer, JL | 1 |
| Bohmaker, K; Diamond, J; Goldstein, M; Lew, JY; Meller, E; Okrongly, D; Puza, T; Schütte, M | 1 |
| Baldessarini, RJ; Kula, NS; Neumeyer, JL; Zong, R | 1 |
| Grol, CJ; Hacksell, U; Johansson, AM; Karlén, A | 1 |
| Agnati, LF; Fuxe, K; Hedlund, PB; Li, XM | 1 |
| Artymyshyn, RP; Facheco, M; Filtz, TM; Ford, C; Guan, W; Molinoff, PB | 1 |
| Di Paolo, T; Lévesque, D | 1 |
| Fuxe, K; Gustafsson, JA; Li, XM; Ogren, SO; von Euler, G | 1 |
| Artymyshyn, RP; Filtz, TM; Guan, W; Molinoff, PB | 1 |
| Evans, DL; Figur, LM; Lahti, RA; Stratman, NC | 1 |
| DeSouza, EB; Grigoriadis, DE; Levant, B | 1 |
| Finnman, UB; Fuxe, K; Hedlund, PB; Li, XM; von Euler, G | 1 |
| McDougall, SA; Mestlin, M | 1 |
| McCarry, BE; Mishra, RK; Ross, GM; Thakur, S | 1 |
| Allard, S; Falardeau, P; Lapointe, S | 1 |
| Costentin, J; Garrido, F; Griffon, N; Launay, C; Mann, A; Sautel, F; Schoenfelder, A; Schwartz, JC; Simon, P; Sokoloff, P | 1 |
| Duke, MA; McDougall, SA; O'Neal, J | 1 |
| Agnati, LF; Finnman, UB; Fuxe, K; Jansson, A; Li, XM | 1 |
| Andersson, K; Bjelke, B; Chen, Y; Gross, J; Herrera-Marschitz, M; Hillefors-Berglund, M; von Euler, G | 1 |
| Baldessarini, RJ; Kula, NS; Neumeyer, JL; Tarazi, FI; Yeghiayan, SK | 1 |
| Artaud, F; Borrelli, E; Chéramy, A; Glowinski, J; Godeheu, G; L'hirondel, M; Saiardi, A | 1 |
| He, SF; Xie, Z | 1 |
| Carr, KD; Garcia-Espana, A; Goldstein, M; Haycock, JW; Lee, KY; Lew, JY; Meller, E | 1 |
| Geurts, M; Hermans, E; Maloteaux, JM | 1 |
| Cumps, J; Geurts, M; Hermans, E; Maloteaux, JM | 1 |
| Ng, SS; Pang, CC | 1 |
| Aston-Jones, G; Druhan, JP; Walters, CL | 2 |
| Hwang, DR; Kegeles, LS; Laruelle, M | 1 |
| Bergson, C; Koh, PO; Lezcano, N; Lidow, MS; Roberts, A; Zhang, L | 1 |
| Matsumoto, A; Pauwels, PJ; Wurch, T | 1 |
| Tamminga, CA | 1 |
| Cumming, P; Gillings, N; Gjedde, A; Hilton, J; Scheffel, U; Wong, DF | 1 |
| Fuxe, K; Järv, J; Lepiku, M; Rinken, A | 1 |
| Boutet-Robinet, EA; De Vries, L; Finana, F; Pauwels, PJ; Wurch, T | 1 |
| Dolbeare, K; Gupta, SK; Johnson, RL; Mishra, RK; Pontoriero, GF | 1 |
| Gazi, L; López-Giménez, JF; Rüdiger, MP; Strange, PG | 1 |
| Huang, Y; Hwang, DR; Kegeles, LS; Laruelle, M; Martinez, D; Narendran, R; Slifstein, M; Sudo, Y; Talbot, PS; Van Berckel, BN | 1 |
| Abi-Dargham, A; Cooper, TB; Erritzoe, D; Huang, Y; Hwang, DR; Kegeles, LS; Laruelle, M; Martinez, D; Narendran, R; Slifstein, M; Talbot, PS | 1 |
| Lin, H; Roberts, DJ; Strange, PG | 1 |
| Casanova, C; Coudé, G; Huppé-Gourgues, F; Lachapelle, P | 1 |
| Boström, D; Del Tredici, AL; Kihlberg, J; Luthman, K; Mohell, N; Saitton, S; Vollinga, RC | 1 |
| Roberts, DJ; Strange, PG | 1 |
| Guan, BC; Li, GH; Li, ZW | 1 |
| Farde, L; Finnema, SJ; Gulyás, B; Halldin, C; Innis, RB; Neumeyer, JL; Seneca, N; Shchukin, E; Sóvágó, J; Wikström, HV | 1 |
| Ekelund, J; Guillin, O; Huang, Y; Hwang, DR; Hwang, Y; Laruelle, M; Martinez, D; Narendran, R; Scher, E; Slifstein, M | 1 |
| Cauli, O; Morelli, M; Pinna, A | 1 |
| Hwang, DR; Hwang, Y; Laruelle, M; Martinez, D; Narendran, R; Reeder, S; Scher, E; Slifstein, M | 1 |
| Platt, DM; Rowlett, JK; Spealman, RD; Yao, WD | 1 |
| Del Tredici, AL; Kihlberg, J; Luthman, K; Saitton, S; Saxin, M; Stenström, T | 1 |
| Cho, EY; Kim, JH; Kim, KM; Min, C; Park, JH | 1 |
| Charntikov, S; Halladay, LR; Herbert, MS; Marquez, EM; McDougall, SA | 1 |
| Bang-Andersen, B; Bundgaard, C; Farde, L; Finnema, SJ; Gulyás, B; Halldin, C; Wikström, HV | 1 |
| Arakawa, R; Farde, L; Finnema, S; Halldin, C; Hirayasu, Y; Ito, H; Kodaka, F; Miyoshi, M; Nakao, R; Okumura, M; Otsuka, T; Seki, C; Sekine, M; Suhara, T; Suzuki, K; Takahashi, H; Takano, H | 1 |
| Carney, JP; Frankle, WG; Laymon, CM; Litschge, MY; Lopresti, BJ; Mason, NS; Mathis, CA; Mountz, JM; Narendran, R | 1 |
| Eriksson, L; Farde, L; Gulyás, B; Halldin, C; Sjöholm, N; Varrone, A | 1 |
| Conde, SV; Gonzalez, C; Monteiro, EC; Obeso, A | 1 |
| Arakawa, R; Ikoma, Y; Ito, H; Kanno, I; Kimura, Y; Kodaka, F; Otsuka, T; Seki, C; Shidahara, M; Suhara, T; Takahashi, H; Takano, H; Turkheimer, FE | 1 |
| Kara, E; Lin, H; Strange, PG | 1 |
| Frankle, WG; Kendro, S; Laymon, CM; Lopresti, BJ; Martinez, D; Mason, NS; Mathis, CA; May, MA; Narendran, R; Velasquez, ND | 1 |
| Halldin, C; Hong, J; Innis, RB; Liow, JS; Pike, VW; Seneca, N; Sibley, DR; Skinbjerg, M; Weinshenker, D | 1 |
| Ding, M; Dorff, P; Elmore, CS; Maier, D; Malmquist, J; Mrzljak, L; Peng, T; Ström, P; Tuke, D; Werkheiser, J; Widzowski, D; Zysk, J | 1 |
| Arakawa, R; Farde, L; Halldin, C; Ito, H; Kodaka, F; Miyoshi, M; Nakayama, K; Okumura, M; Otsuka, T; Suhara, T; Takahashi, H; Takano, H | 1 |
| Cumming, P; Kjaerby, C; Knudsen, GM; Palner, M | 1 |
| Chen, CM; Frankle, WG; Himes, ML; Lopresti, BJ; Martinez, D; Mason, NS; Mathis, CA; May, MA; Narendran, R; Price, JC | 1 |
| Farde, L; Fujie, S; Fujiwara, H; Halldin, C; Ito, H; Kimura, Y; Kodaka, F; Nakayama, K; Sasaki, T; Suhara, T; Takano, H | 1 |
| Brive, L; Luthman, K; Malo, M; Persson, R; Svensson, P | 1 |
| Amodeo, LR; Crawford, CA; Der-Ghazarian, T; Gonzalez, AE; Gutierrez, A; Humphrey, DE; McDougall, SA; Valentine, JM; Widarma, CB | 1 |
| Crawford, CA; Gonzalez, AE; Humphrey, DE; McDougall, SA; Valentine, JM; Widarma, CB | 1 |
| Gonzalez, AE; McDougall, SA; Mohd-Yusof, A; Veliz, A | 1 |
| Fujiwara, H; Higuchi, M; Ito, H; Kimura, Y; Kodaka, F; Kubota, M; Moriguchi, S; Nagashima, T; Okubo, Y; Suhara, T; Takahashi, H; Takahata, K; Takano, H | 1 |
| Frankle, WG; Himes, M; Mason, NS; Mathis, CA; Narendran, R; Paris, J | 1 |
| Costall, B; Naylor, RJ | 1 |
| Agnati, L; Dafeldecker, WP; Fuxe, K; Guarino, J; Kosersky, DS; Neumeyer, JL; Reinhard, JF | 1 |
| Baldessarini, RJ; Gao, YG; Kula, NS; Neumeyer, JL | 2 |
| Banzatti, C; Carfagna, N; Commisso, R; Heidempergher, F; Melloni, P; Pegrassi, L | 1 |
| Anlezark, G; Law, SJ; Meldrum, B; Neumeyer, JL; Watling, KJ | 1 |
| Arana, GW; Baldessarini, RJ; Kula, NS; Lamont, JS; Law, SJ; Neumeyer, JL | 1 |
| Griffon, N; Lévesque, D; Pilon, C; Sautel, F; Schwartz, JC; Sokoloff, P | 1 |
| Emms, F; Freedman, SB; Knowles, MR; Marwood, R; McAllister, G; Patel, S; Seabrook, GR | 1 |
| Brusniak, MY; Neve, KA; Pearlman, RS; Wilcox, RE | 1 |
| Brusniak, MY; DuRand, CJ; Huang, WH; Neve, KA; Pearlman, RS; Teeter, MM; Wiens, BL; Wilcox, DM; Wilcox, RE | 1 |
| Baldessarini, RJ; Branfman, AR; Neumeyer, JL; Zhang, A; Zhang, Y | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Baldessarini, RJ; Gardner, MP; Neumeyer, JL; Si, YG; Tarazi, FI | 1 |
| George, SR; Neumeyer, JL; Seeman, P; Si, YG; Sromek, AW; Zhang, T | 1 |
| Liu, C; Park, H; Urs, AN; Urs, NM; Wang, Q; Zimmerman, J | 1 |
4 review(s) available for apomorphine and n-n-propylnorapomorphine
| Article | Year |
|---|---|
Intramembrane interactions between neurotensin receptors and dopamine D2 receptors as a major mechanism for the neuroleptic-like action of neurotensin.
Topics: Animals; Antipsychotic Agents; Apomorphine; Basal Ganglia; Behavior, Animal; Brain; Cell Membrane; Dopamine; Dopamine Agents; Enkephalins; gamma-Aminobutyric Acid; GTP-Binding Proteins; Neurons; Neurotensin; Oxidopamine; Rats; Receptors, Dopamine D2; Receptors, Neurotensin; Receptors, Neurotransmitter | 1992 |
Multiple receptors for brain dopamine in behavior regulation: concept of dopamine-E and dopamine-I receptors.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Behavior, Animal; Brain; Cats; Corpus Striatum; Dextroamphetamine; Dopamine; Ergot Alkaloids; Fluorescence; Haloperidol; Histocytochemistry; Humans; Hyperkinesis; Hypothermia; Methyltyrosines; Mice; Motor Activity; Naphthalenes; Neurons; Nucleus Accumbens; Rats; Receptors, Adrenergic, alpha; Receptors, Dopamine; Reserpine; Septal Nuclei; Stereotyped Behavior; Tetrahydronaphthalenes | 1980 |
Partial dopamine agonists in the treatment of psychosis.
Topics: Animals; Apomorphine; Autoreceptors; Brain; Dopamine Agonists; Humans; Piperidines; Psychotic Disorders; Receptors, Dopamine | 2002 |
Advances in development of dopaminergic aporphinoids.
Topics: Animals; Apomorphine; Aporphines; Dopamine Agents; Humans; Structure-Activity Relationship | 2007 |
4 trial(s) available for apomorphine and n-n-propylnorapomorphine
| Article | Year |
|---|---|
Apomorphine's antipsychotic activity.
Topics: Antipsychotic Agents; Apomorphine; Clinical Trials as Topic; Dose-Response Relationship, Drug; Humans; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology | 1985 |
Dopamine agonist treatment of schizophrenia with N-propylnorapomorphine.
Topics: Administration, Oral; Adult; Antiparkinson Agents; Antipsychotic Agents; Apomorphine; Clinical Trials as Topic; Dopamine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Tolerance; Humans; Placebos; Prolactin; Psychiatric Status Rating Scales; Receptors, Dopamine; Schizophrenia; Schizophrenic Psychology | 1986 |
Effect of risperidone on high-affinity state of dopamine D2 receptors: a PET study with agonist ligand [11C](R)-2-CH3O-N-n-propylnorapomorphine.
Topics: Adult; Apomorphine; Brain; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Humans; Ligands; Magnetic Resonance Imaging; Male; Positron-Emission Tomography; Raclopride; Radiopharmaceuticals; Receptors, Dopamine D2; Risperidone; Schizophrenia; Young Adult | 2011 |
Imaging of dopamine D2/3 agonist binding in cocaine dependence: a [11C]NPA positron emission tomography study.
Topics: Adolescent; Adult; Apomorphine; Cocaine-Related Disorders; Corpus Striatum; Dopamine Agonists; Female; Humans; Male; Middle Aged; Positron-Emission Tomography; Receptors, Dopamine D2; Receptors, Dopamine D3; Young Adult | 2011 |
277 other study(ies) available for apomorphine and n-n-propylnorapomorphine
| Article | Year |
|---|---|
Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding, Competitive; Blotting, Northern; Brain; Cell Line; Cell Membrane; Cloning, Molecular; Dopamine; Humans; Kinetics; Molecular Sequence Data; Molecular Weight; Oligonucleotide Probes; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D5; RNA, Messenger; Sequence Homology, Nucleic Acid; Transfection | 1991 |
Pharmacological basis for N-n-propylnorapomorphine induced stereotypic cage climbing and behavioral arousal in mice.
Topics: Animals; Antiparkinson Agents; Apomorphine; Arousal; Behavior; Behavior, Animal; Dose-Response Relationship, Drug; Humans; Male; Mice; Neurotransmitter Agents; Stereotyped Behavior; Time Factors | 1979 |
Penile erection induced by apomorphine and N-n-propyl-norapomorphine in rats.
Topics: Animals; Antipsychotic Agents; Apomorphine; Dose-Response Relationship, Drug; Drug Interactions; Male; Penis; Rats; Receptors, Dopamine; Sexual Behavior, Animal | 1979 |
Antiparkinsonian drug doses and neuroleptic receptors.
Topics: Animals; Antiparkinson Agents; Apomorphine; Bromocriptine; Cattle; Caudate Nucleus; Haloperidol; In Vitro Techniques; Receptors, Dopamine; Spiperone; Tritium | 1978 |
Dopamine-like renal and mesenteric vasodilation caused by apomorphine 6-propylnorapomorphine and 2-amino-6, 7-dihydroxy-1,2,3,4-tetrahydronaphthalene.
Topics: Animals; Apomorphine; Dogs; Dopamine; Femoral Artery; Haloperidol; Kidney; Mesenteric Arteries; Naphthols; Receptors, Drug; Regional Blood Flow; Structure-Activity Relationship; Vasodilator Agents | 1976 |
Characterization of the inhibitory effect of adrenocorticotropin/melanocyte-stimulating hormone-like peptides on the binding of dopamine receptor ligands to the dopamine D2 receptor in vitro.
Topics: Adrenocorticotropic Hormone; Age Factors; Animals; Apomorphine; Binding, Competitive; Dopamine D2 Receptor Antagonists; Guanylyl Imidodiphosphate; Ligands; Male; Melanocyte-Stimulating Hormones; Peptides; Rats; Rats, Wistar; Receptors, Dopamine D2; Spiperone; Temperature; Time Factors | 1992 |
Effects of irreversible dopamine receptor inactivation on locomotor activity and grooming in the 17- and 90-day-old rat.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Apomorphine; Dopamine Agents; Dopamine Antagonists; Female; Grooming; Male; Motor Activity; Quinolines; Rats; Rats, Inbred Strains | 1992 |
The effects of pertussis toxin on dopamine D2 and serotonin 5-HT1A autoreceptor-mediated inhibition of neurotransmitter synthesis: relationship to receptor reserve.
Topics: 5-Hydroxytryptophan; Animals; Apomorphine; Brain; Dopamine Agents; GTP-Binding Proteins; Levodopa; Male; Neurotransmitter Agents; Pertussis Toxin; Piperidines; Quinolines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Serotonin; Ribose; Virulence Factors, Bordetella | 1992 |
Effects of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline on the prolactin suppression induced by a series of full and partial dopamine D2 receptor agonists in male rats.
Topics: 4-Butyrolactone; Adrenergic alpha-Antagonists; Animals; Apomorphine; Dopamine Agents; Ergolines; Levodopa; Male; Piperidines; Prolactin; Quinolines; Rats; Rats, Sprague-Dawley | 1992 |
Chronic nicotine treatment decreases dopamine D2 agonist binding in the rat basal ganglia.
Topics: Animals; Apomorphine; Autoradiography; Basal Ganglia; Dopamine Agents; Dopamine D2 Receptor Antagonists; Male; Nicotine; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Sulpiride | 1992 |
Effect of lithium and anesthetics on in vivo binding of dopamine receptors.
Topics: Animals; Apomorphine; Benzazepines; Ketamine; Lithium; Male; Mice; Mice, Inbred C3H; Pentobarbital; Rats; Receptors, Dopamine; Spiperone | 1991 |
Effects of the isomers of N-n-propylnorapomorphine and haloperidol on regional concentrations of neurotensin in rat brain.
Topics: Animals; Apomorphine; Brain; Dopamine Agents; Haloperidol; Isomerism; Male; Neurotensin; Organ Specificity; Rats; Rats, Inbred Strains; Reference Values | 1991 |
Inhibition of dopamine synthesis in rat striatal minces: evidence of dopamine autoreceptor supersensitivity to S(+)- but not R(-)-N-n-propylnorapomorphine after pretreatment with fluphenazine.
Topics: Animals; Apomorphine; Corpus Striatum; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Fluphenazine; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereoisomerism; Tyrosine 3-Monooxygenase | 1991 |
Selective antidopaminergic effects of S(+)N-n-propylnoraporphines in limbic versus extrapyramidal sites in rat brain: comparisons with typical and atypical antipsychotic agents.
Topics: Animals; Antipsychotic Agents; Apomorphine; Clozapine; Dibenzothiazepines; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Haloperidol; Limbic System; Male; Motor Activity; Pyramidal Tracts; Quetiapine Fumarate; Rats; Rats, Inbred Strains | 1991 |
Stimulation of high-affinity adenosine A2 receptors decreases the affinity of dopamine D2 receptors in rat striatal membranes.
Topics: Adenosine; Animals; Apomorphine; Benzazepines; Binding, Competitive; Cell Membrane; Corpus Striatum; Dopamine; Dopamine Agents; Kinetics; Male; Phenethylamines; Phenylisopropyladenosine; Raclopride; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Purinergic; Salicylamides; Theophylline | 1991 |
Vanadate inhibits agonist binding to D2 dopamine receptor.
Topics: Animals; Apomorphine; Binding, Competitive; Cattle; Cell Membrane; Corpus Striatum; Dopamine Agents; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Kinetics; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Vanadates | 1991 |
ACTH/MSH-like peptides inhibit the binding of dopaminergic ligands to the dopamine D2 receptor in vitro.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenocorticotropic Hormone; Amino Acid Sequence; Animals; Apomorphine; Cosyntropin; Dopamine Agents; In Vitro Techniques; Kinetics; Ligands; Male; Melanocyte-Stimulating Hormones; Molecular Sequence Data; Peptide Fragments; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Structure-Activity Relationship; Tetrahydronaphthalenes | 1991 |
5-Oxygenated N-alkyl- and N,N-Dialkyl-2-amino-1-methyltetralins. Effects of structure and stereochemistry on dopamine-D2-receptor affinity.
Topics: Animals; Apomorphine; Binding, Competitive; Cattle; Computer Simulation; Corpus Striatum; Culture Techniques; Dopamine Agents; Oxygen; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Stereoisomerism; Structure-Activity Relationship; Tetrahydronaphthalenes; Tritium | 1991 |
Effects of B-HT 920 in the tail-suspension test.
Topics: Adrenergic alpha-Agonists; Animals; Apomorphine; Azepines; Clonidine; Depressive Disorder; Dopamine Agents; Imipramine; Male; Mice; Motor Activity; Yohimbine | 1991 |
A trypsin inhibitor-like peptide PEC-60 reduces the affinity of dopamine D2 agonist binding sites in rat neostriatal membranes.
Topics: Animals; Apomorphine; Binding Sites; Corpus Striatum; Dopamine; Dopamine Antagonists; Kinetics; Membranes; Peptides; Raclopride; Rats; Salicylamides; Trypsin Inhibitors | 1991 |
Selective and quantitative isolation and determination of apomorphine in human plasma.
Topics: Apomorphine; Chromatography, High Pressure Liquid; Electrochemistry; Humans; Reproducibility of Results | 1991 |
Neurotensin decreases the affinity of dopamine D2 agonist binding by a G protein-independent mechanism.
Topics: Adenosine Diphosphate Ribose; Animals; Apomorphine; Corpus Striatum; Ethylmaleimide; GTP-Binding Proteins; Male; Neurotensin; Pertussis Toxin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Virulence Factors, Bordetella | 1991 |
Synaptic concentration of dopamine in the mouse striatum in relationship to the kinetic properties of the dopamine receptors and uptake mechanism.
Topics: Aminoquinolines; Animals; Apomorphine; Benzazepines; Binding, Competitive; Corpus Striatum; Dopamine; Kinetics; Male; Mice; Raclopride; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Salicylamides; Synapses; Synaptosomes; Tetrahydronaphthalenes | 1991 |
Phosphorylation by cyclic AMP-dependent protein kinase modulates agonist binding to the D2 dopamine receptor.
Topics: Animals; Apomorphine; Cattle; Cell Membrane; Corpus Striatum; Cyclic AMP; Guanine Nucleotides; Kinetics; Molecular Weight; Phosphorylation; Protein Kinases; Receptors, Dopamine; Receptors, Dopamine D2; Substrate Specificity | 1991 |
Comparison of the clinical pharmacology of (-)NPA and levodopa in Parkinson's disease.
Topics: Antiparkinson Agents; Apomorphine; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Injections, Intravenous; Levodopa; Middle Aged; Parkinson Disease; Receptors, Dopamine | 1991 |
4-(1,2,5,6-Tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines: a novel class of compounds with central dopamine agonist properties.
Topics: Animals; Apomorphine; Chemical Phenomena; Chemistry; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Dopamine Agents; Haloperidol; Male; Molecular Conformation; Molecular Structure; Motor Activity; Neurons; Pyridines; Rats; Receptors, Dopamine; Receptors, Dopamine D2; Structure-Activity Relationship; Substantia Nigra; Thermodynamics; Thiazoles | 1990 |
Structural differences between dopamine D2 receptors present in a rat pituitary adenoma and in transplantable rat pituitary tumors 7315a and MtTW15.
Topics: Adenoma; Animals; Apomorphine; Binding, Competitive; Carrier Proteins; Chemical Phenomena; Chemistry; Dopamine Agents; Ethylmaleimide; Neoplasm Transplantation; Pituitary Neoplasms; Rats; Receptors, Dopamine; Receptors, Dopamine D2; Solubility; Spiperone | 1990 |
The actions of (-)N-n-propylnorapomorphine and selective dopamine D1 and D2 receptor agonists to modify the release of [3H]dopamine from the rat nucleus accumbens.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Apomorphine; Benzazepines; Dopamine; Dopamine Agents; Ergolines; Female; Fluphenazine; Motor Activity; Nucleus Accumbens; Potassium; Quinpirole; Rats; Receptors, Dopamine; Septal Nuclei; Sulpiride | 1990 |
Presynaptic inhibition of dopamine synthesis in rat striatal tissue by enantiomeric mono- and dihydroxyaporphines.
Topics: Animals; Apomorphine; Aporphines; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Reserpine; Stereoisomerism; Tyrosine 3-Monooxygenase | 1990 |
Neurochemical studies with the potential antipsychotic compound trans-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H- dibenz[2,3:6,7]oxepino[4,5-c]pyrrolidine maleate.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Apomorphine; Autonomic Nervous System; Benzazepines; Brain Chemistry; Corpus Striatum; Cyclic AMP; Dibenzocycloheptenes; Dibenzoxepins; Heterocyclic Compounds, 4 or More Rings; In Vitro Techniques; Male; Membranes; Mianserin; Prazosin; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Serotonin; Tetrahydronaphthalenes; Yohimbine | 1990 |
Adenosine A2 stimulation of tyrosine hydroxylase in rat striatal minces is reversed by dopamine D2 autoreceptor activation.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Animals; Apomorphine; Colforsin; Corpus Striatum; Cyclic AMP; Dopamine Agents; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Purinergic; Theophylline; Tyrosine 3-Monooxygenase | 1990 |
Loss of dopamine receptors in the olfactory bulb of patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Apomorphine; Autoradiography; Brain; Dopamine Agents; Female; Humans; Male; Middle Aged; Olfactory Bulb; Organ Size; Receptors, Dopamine; Receptors, Dopamine D2; Tritium | 1990 |
Intraventricular injection of neurotensin reduces dopamine D2 agonist binding in rat forebrain and intermediate lobe of the pituitary gland. Relationship to serum hormone levels and nerve terminal coexistence.
Topics: Animals; Apomorphine; Autoradiography; Brain; Cerebral Ventricles; Colchicine; Corticosterone; Dopamine Agents; Hydroxydopamines; Injections, Intraventricular; Luteinizing Hormone; Male; Nerve Endings; Neurotensin; Organ Specificity; Oxidopamine; Pituitary Gland; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Tritium; Tyrosine 3-Monooxygenase | 1990 |
Irreversible receptor inactivation reveals differences in dopamine receptor reserve between A9 and A10 dopamine systems: an electrophysiological analysis.
Topics: Animals; Apomorphine; Dopamine; Dopamine Agents; Dopamine Antagonists; Electrophysiology; Evoked Potentials; Haloperidol; Kinetics; Male; Neurons; Quinolines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reference Values; Substantia Nigra; Tegmentum Mesencephali | 1990 |
In vivo interaction of cabergoline with rat brain dopamine receptors labelled with [3H]N-n-propylnorapomorphine.
Topics: Administration, Oral; Animals; Apomorphine; Brain Chemistry; Bromocriptine; Cabergoline; Dopamine Agents; Dose-Response Relationship, Drug; Ergolines; Female; In Vitro Techniques; Injections, Intravenous; Kinetics; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1990 |
Synthesis and pharmacology of the enantiomers of cis-7-hydroxy-3-methyl-2-(dipropylamino)tetralin.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Apomorphine; Binding, Competitive; Cattle; Chemical Phenomena; Chemistry, Physical; Computer Simulation; Crystallography; Dihydroxyphenylalanine; Dopamine Antagonists; In Vitro Techniques; Isomerism; Male; Molecular Conformation; Molecular Structure; Motor Activity; Rats; Reserpine; Spiperone; Structure-Activity Relationship; Tetrahydronaphthalenes; X-Ray Diffraction | 1990 |
Dopamine D-2 agonists with high and low efficacies: differentiation by behavioural techniques.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Benzamides; Drug Combinations; Male; Motor Activity; Rats; Receptors, Dopamine; Receptors, Dopamine D2; Stereotyped Behavior | 1990 |
The role of multiple dopamine receptors in apomorphine and N-n-propylnorapomorphine-induced climbing and hypothermia.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Benzamides; Benzazepines; Body Temperature; Dose-Response Relationship, Drug; Ergolines; Female; Mice; Quinpirole; Receptors, Dopamine; Stereotyped Behavior | 1990 |
Effects of isomers of hydroxyaporphines on dopamine metabolism in rat brain regions.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Aporphines; Brain; Dopamine; Homovanillic Acid; Male; Rats; Rats, Inbred Strains; Stereoisomerism; Structure-Activity Relationship | 1990 |
Dopamine antagonists reduce spontaneous electrical activity in cultured mammalian neurons from ventral mesencephalon.
Topics: Action Potentials; Animals; Apomorphine; Butaclamol; Cells, Cultured; Dibenzocycloheptenes; Dopamine Antagonists; Fetus; Haloperidol; Membrane Potentials; Mesencephalon; Mice; Mice, Inbred ICR; Neurons; Receptors, Dopamine; Spinal Cord; Spiperone | 1986 |
Immuno-photoaffinity labeling of the D2-dopamine receptor.
Topics: Affinity Labels; Animals; Apomorphine; Azides; Butaclamol; Cattle; Corpus Striatum; Haloperidol; Immunologic Techniques; Kinetics; Molecular Weight; Photochemistry; Receptors, Dopamine; Spiperone | 1988 |
Neurotensin modulates the binding characteristics of dopamine D2 receptors in rat striatal membranes also following treatment with toluene.
Topics: Animals; Apomorphine; Cell Membrane; Corpus Striatum; Male; Neurotensin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Toluene | 1989 |
Distribution of dopamine D-2 receptors in the rat striatal complex and its comparison with acetylcholinesterase.
Topics: Acetylcholinesterase; Animals; Apomorphine; Autoradiography; Corpus Striatum; Histocytochemistry; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2 | 1989 |
Differences in dopamine receptor reserve for N-n-propylnorapomorphine enantiomers: single unit recording studies after partial inactivation of receptors by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline.
Topics: Animals; Apomorphine; Dopamine Agents; Dose-Response Relationship, Drug; Male; Quinolines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereoisomerism | 1989 |
Behavioral recovery after irreversible inactivation of D-1 and D-2 dopamine receptors.
Topics: Animals; Apomorphine; Benzazepines; Dopamine Agents; Dopamine Antagonists; Flupenthixol; Male; Quinolines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Reference Values; Stereotyped Behavior; Sulpiride; Thioxanthenes | 1989 |
Hypothermia in mice: D2 dopamine receptor mediation and absence of spare receptors.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adrenergic alpha-Antagonists; Animals; Apomorphine; Benzazepines; Body Temperature; Dopamine Agents; Dopamine Antagonists; Ergolines; Hypothermia; Male; Mice; Mice, Inbred Strains; Quinolines; Quinpirole; Receptors, Dopamine; Receptors, Dopamine D2; Sulpiride | 1989 |
Stereotypies elicited by injection of N-propylnorapomorphine into striatal subregions and nucleus accumbens.
Topics: Animals; Apomorphine; Corpus Striatum; Dopamine Agents; Dose-Response Relationship, Drug; Male; Nucleus Accumbens; Rats; Rats, Inbred Strains; Septal Nuclei; Stereotyped Behavior | 1989 |
Association of two pertussis toxin-sensitive G-proteins with the D2-dopamine receptor from bovine striatum.
Topics: Adenosine Diphosphate; Animals; Apomorphine; Blotting, Western; Cattle; Chromatography, Affinity; Corpus Striatum; Dopamine Agents; GTP Phosphohydrolases; GTP-Binding Proteins; Guanine Nucleotides; Kinetics; Membranes; Pertussis Toxin; Receptors, Dopamine; Solubility; Spiperone; Virulence Factors, Bordetella | 1989 |
Kinetic properties of the in vivo accumulation of 3H-(-)-N-n-propylnorapomorphine in mouse brain.
Topics: 4-Butyrolactone; Animals; Apomorphine; Benzazepines; Brain Chemistry; Corpus Striatum; Dextroamphetamine; Dopamine Agents; In Vitro Techniques; Male; Methylphenidate; Mice; Motor Activity; Olfactory Bulb; Reserpine; Synapses | 1989 |
Desenkephalin-gamma-endorphin is an antagonist of the hyperactivity response induced by infusion of dopamine into the nucleus accumbens of rat and ventral striatum of marmoset.
Topics: Animals; Apomorphine; beta-Endorphin; Callitrichinae; Corpus Striatum; Dopamine; Dopamine Agents; Dopamine Antagonists; Female; Fluphenazine; Haloperidol; Injections; Male; Motor Activity; Nucleus Accumbens; Rats; Rats, Inbred Strains; Septal Nuclei | 1989 |
Dopamine D2 receptors in the anterior pituitary: a single population without reciprocal antagonist/agonist states.
Topics: Animals; Apomorphine; Binding, Competitive; Butaclamol; Butyrophenones; Dopamine; Dopamine Antagonists; Guanylyl Imidodiphosphate; Norepinephrine; Pituitary Gland, Anterior; Receptors, Dopamine; Receptors, Dopamine D2; Serotonin; Sodium Chloride; Spiperone; Swine; Tetrahydronaphthalenes | 1985 |
Intraventricular injection of neurotensin reduces the binding of dopamine D-2 receptors in the rat forebrain.
Topics: Animals; Apomorphine; Brain; Corpus Striatum; Injections, Intraventricular; Male; Neurotensin; Nucleus Accumbens; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1989 |
[Stimulation by cerulein--an analog of the octapeptide cholecystokinin--of 3H-spiroperidol binding after the long-term administration of neuroleptics].
Topics: Animals; Antipsychotic Agents; Apomorphine; Brain; Butyrophenones; Ceruletide; Drug Interactions; Male; Mice; Spiperone; Stimulation, Chemical; Time Factors; Tritium | 1985 |
Relative selectivity of 6,7-dihydroxy-2-dimethylaminotetralin, N-n-propyl-3-(3-hydroxyphenyl)piperidine, N-n-propylnorapomorphine and pergolide as agonists at striatal dopamine autoreceptors and postsynaptic dopamine receptors.
Topics: Acetylcholine; Animals; Apomorphine; Corpus Striatum; Dihydroxyphenylalanine; Ergolines; Haloperidol; Homovanillic Acid; Male; Naphthalenes; Pergolide; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reserpine; Sodium Oxybate; Tetrahydronaphthalenes; Tyrosine 3-Monooxygenase | 1985 |
Evidence for cholecystokinin-dopamine receptor interactions in the central nervous system of the adult and old rat. Studies on their functional meaning.
Topics: Aging; Animals; Apomorphine; Brain; Cholecystokinin; Haloperidol; Male; Neurons; Nucleus Accumbens; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sincalide; Tyrosine 3-Monooxygenase | 1985 |
Effect of chronic treatment with morphine on the binding of 3H-N-n-propylnorapomorphine to striatal membranes of rats: influence of prolyl-leucyl-glycinamide.
Topics: Animals; Antiparkinson Agents; Apomorphine; beta-Endorphin; Corpus Striatum; Drug Tolerance; Endorphins; Kinetics; Male; Membranes; Morphine; MSH Release-Inhibiting Hormone; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1985 |
Effects of remoxipride and some related new substituted salicylamides on rat brain receptors.
Topics: Adenylyl Cyclases; Animals; Antipsychotic Agents; Apomorphine; Benzamides; Brain; Domperidone; Dopamine; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Neurotransmitter; Receptors, Serotonin; Remoxipride; Salicylamides; Spiperone; Structure-Activity Relationship; Tetrahydronaphthalenes; Tritium | 1986 |
Relationship between receptor occupancy and response at striatal dopamine autoreceptors.
Topics: 4-Butyrolactone; Adrenergic alpha-Antagonists; Animals; Apomorphine; Corpus Striatum; Dihydroxyphenylalanine; Homeostasis; Hydrazines; Levodopa; Male; Piperidines; Quinolines; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1987 |
Behavioural consequences of the infusion of dopamine into the nucleus accumbens of the common marmoset (Callithrix jacchus).
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Callithrix; Dopamine; Dopamine Antagonists; Female; Hyperkinesis; Injections; Male; Motor Activity; Nucleus Accumbens; Septal Nuclei | 1987 |
Interaction of L-prolyl-L-leucyl glycinamide with dopamine D2 receptor: evidence for modulation of agonist affinity states in bovine striatal membranes.
Topics: Animals; Apomorphine; Cattle; Corpus Striatum; Guanylyl Imidodiphosphate; MSH Release-Inhibiting Hormone; Osmolar Concentration; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone | 1988 |
Absence of receptor reserve at striatal dopamine receptors regulating cholinergic neuronal activity.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Animals; Antiparkinson Agents; Apomorphine; Choline; Dose-Response Relationship, Drug; Male; Neurons; Parasympathetic Nervous System; Quinolines; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1988 |
Regulation of anterior pituitary D2 dopamine receptors by magnesium and sodium ions.
Topics: Animals; Apomorphine; Dopamine; Guanine Nucleotides; Magnesium; Pituitary Gland, Anterior; Receptors, Dopamine; Receptors, Dopamine D2; Sodium; Spiperone; Swine | 1985 |
Comparison of motor depressant effects of caerulein and N-propylnorapomorphine in mice.
Topics: 5,7-Dihydroxytryptamine; Animals; Apomorphine; Ceruletide; Depression, Chemical; Exploratory Behavior; Fenclonine; Haloperidol; Hydroxydopamines; Male; Mice; Motor Activity; Nerve Endings; Oxidopamine; Receptors, Dopamine; Receptors, Serotonin; Sincalide; Spiperone | 1986 |
Aporphines 65: chemical, microbial synthesis and characterization by gas chromatography/mass spectrometry of (R)-(-)-10-hydroxy 11-methoxy-N-n-propylnoraporphine, a potential metabolite of N-n-propylnorapomorphine.
Topics: Apomorphine; Aporphines; Bacteria; Biotransformation; Chemical Phenomena; Chemistry; Gas Chromatography-Mass Spectrometry | 1986 |
Dopaminergic 2-aminotetralins: affinities for dopamine D2-receptors, molecular structures, and conformational preferences.
Topics: Apomorphine; Magnetic Resonance Spectroscopy; Molecular Conformation; Naphthalenes; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Structure-Activity Relationship; Tetrahydronaphthalenes; Tritium; X-Ray Diffraction | 1986 |
Autoradiographic distribution of the D1 agonist [3H]SKF 38393, in the rat brain and spinal cord. Comparison with the distribution of D2 dopamine receptors.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Autoradiography; Benzazepines; Binding Sites; Brain; Corpus Striatum; Ibotenic Acid; Kinetics; Male; Neurons; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Spinal Cord; Tritium | 1986 |
The benzazepine, SCH 23390, inhibits 3H-NPA binding in mouse brain in vivo.
Topics: Animals; Apomorphine; Benzazepines; Binding, Competitive; Male; Mice; Raclopride; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Salicylamides; Spiperone | 1986 |
Differential recovery rates of rat D2 dopamine receptors as a function of aging and chronic reserpine treatment following irreversible modification: a key to receptor regulatory mechanisms.
Topics: Aging; Animals; Apomorphine; Corpus Striatum; Guanylyl Imidodiphosphate; Haloperidol; In Vitro Techniques; Kinetics; Male; Quinolines; Radioligand Assay; Rats; Rats, Inbred F344; Receptors, Dopamine; Receptors, Dopamine D2; Reserpine; Spiperone | 1987 |
Dopamine D2 receptor stimulation decreases the inositol trisphosphate level of rat striatal slices.
Topics: Animals; Apomorphine; Corpus Striatum; Ergolines; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Quinpirole; Rats; Receptors, Dopamine; Receptors, Dopamine D2; Sugar Phosphates | 1987 |
Characterization of D-2 dopamine receptors in a tumor of the rat anterior pituitary gland.
Topics: Adenylyl Cyclase Inhibitors; Animals; Apomorphine; Colforsin; Dopamine; Female; Guanosine Triphosphate; Pituitary Gland, Anterior; Pituitary Neoplasms; Rats; Rats, Inbred BUF; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone | 1987 |
Characterization of D2 dopamine receptors in dopamine-resistant prolactin-secreting rat pituitary tumors 7315a and MtTW15.
Topics: Affinity Labels; Animals; Apomorphine; Cell Membrane; Dopamine; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Female; Guanylyl Imidodiphosphate; Molecular Weight; Neoplasm Transplantation; Photochemistry; Pituitary Neoplasms; Prolactin; Rats; Rats, Inbred BUF; Rats, Inbred WF; Receptors, Dopamine; Receptors, Dopamine D2; Solubility; Spiperone | 1987 |
The discriminative stimulus properties of the D-1 agonist SK&F 38393 and the D-2 agonist (-)-NPA are mediated by separate mechanisms.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Benzazepines; Dextroamphetamine; Discrimination Learning; Male; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Stereoisomerism | 1988 |
Regional differences in reappearance of D2-dopamine receptors in the rat caudate-putamen complex after irreversible inactivation.
Topics: Animals; Apomorphine; Autoradiography; Caudate Nucleus; Kinetics; Male; Organ Specificity; Putamen; Quinolines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Reference Values; Tritium | 1988 |
In vivo labelling of rat brain dopamine D-2 receptors. Stereoselective blockade by the D-2 antagonist raclopride and its enantiomer of 3H-spiperone, 3H-N,N-propylnorapomorphine and 3H-raclopride binding in the rat brain.
Topics: Animals; Apomorphine; Binding, Competitive; Brain; Kinetics; Male; Organ Specificity; Raclopride; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Salicylamides; Spiperone; Stereoisomerism | 1988 |
Increased sensitivity to dopamine agonists following a single dose of morphine or levorphanol in mice.
Topics: Animals; Apomorphine; Brain; Brain Stem; Cerebral Cortex; Chlorides; Corpus Striatum; Dextrorphan; Drug Synergism; Hippocampus; Levorphanol; Lithium; Lithium Chloride; Male; Mice; Morphine; Motor Activity; Naloxone; Narcotics; Receptors, Dopamine; Spiperone | 1985 |
Dopamine, acting through D-2 receptors, inhibits rat striatal adenylate cyclase by a GTP-dependent process.
Topics: Adenylyl Cyclase Inhibitors; Animals; Apomorphine; Benzazepines; Calcium; Corpus Striatum; Cyclic AMP; Dopamine; Guanosine Triphosphate; Guanylyl Imidodiphosphate; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2 | 1986 |
Behavioral effects of apomorphine isomers in the rat: selective locomotor-inhibitory effects of S(+)N-n-propylnorapomorphine.
Topics: Animals; Apomorphine; Behavior, Animal; Catalepsy; Male; Motor Activity; Rats; Stereoisomerism; Stereotyped Behavior | 1986 |
Alkylation of the bovine anterior pituitary D2-dopamine receptor: inconsistency with predictions of the ternary complex model.
Topics: Alkylation; Animals; Apomorphine; Binding, Competitive; Cattle; Cell Membrane; Computer Simulation; Dopamine Antagonists; Fluphenazine; GTP-Binding Proteins; In Vitro Techniques; Ligands; Pituitary Gland, Anterior; Receptors, Dopamine; Spiperone; Structure-Activity Relationship | 1987 |
Chronic haloperidol does not alter agonist affinity for dopamine receptors in vitro.
Topics: Animals; Apomorphine; Binding, Competitive; Corpus Striatum; Haloperidol; Indoles; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone | 1985 |
Complete conversion of brain D2 dopamine receptors from the high- to the low-affinity state for dopamine agonists, using sodium ions and guanine nucleotide.
Topics: Animals; Apomorphine; Brain; Guanine Nucleotides; In Vitro Techniques; Ketanserin; Male; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sodium; Spiperone; Tetrahydronaphthalenes; Tritium | 1985 |
Heterogeneous distribution of dopamine D2 receptors within the rat striatum as revealed by autoradiography of [3H]N-n-propylnorapomorphine binding sites.
Topics: Animals; Apomorphine; Autoradiography; Computers; Corpus Striatum; In Vitro Techniques; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2 | 1985 |
Effects of N-n-propylnorapomorphine enantiomers on single unit activity of substantia nigra pars compacta and ventral tegmental area dopamine neurons.
Topics: Animals; Antiparkinson Agents; Apomorphine; Dose-Response Relationship, Drug; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereoisomerism; Substantia Nigra; Tegmentum Mesencephali | 1988 |
Determination of N-n-propylnorapomorphine in serum and brain tissue by gas chromatography-negative ion chemical ionization mass spectrometry.
Topics: Animals; Antiparkinson Agents; Apomorphine; Biotransformation; Brain Chemistry; Gas Chromatography-Mass Spectrometry; Indicators and Reagents; Male; Rats; Rats, Inbred Strains; Solvents; Stereoisomerism | 1988 |
Enhancement by the D1 dopamine agonist SKF 38393 of specific components of stereotypy elicited by the D2 agonists LY 171555 and RU 24213.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Behavior, Animal; Benzazepines; Dose-Response Relationship, Drug; Ergolines; Male; Phenethylamines; Quinpirole; Rats; Receptors, Dopamine; Stereotyped Behavior | 1988 |
6- and 8-hydroxy-3,4-dihydro-3-(dipropylamino)-2H-1-benzopyrans. Dopamine agonists with autoreceptor selectivity.
Topics: 4-Butyrolactone; Animals; Apomorphine; Benzopyrans; Brain; Chromans; Dopamine; Haloperidol; In Vitro Techniques; Neurons; Rats; Receptors, Dopamine; Reserpine | 1988 |
High-performance liquid chromatographic separation and electrochemical or spectrophotometric determination of R(-)N-n-propylnorapomorphine and R(-)10,11-methylenedioxy-N-n-propylnoraporphine in primate plasma.
Topics: Animals; Apomorphine; Aporphines; Chromatography, High Pressure Liquid; Electrochemistry; Macaca fascicularis; Spectrophotometry, Ultraviolet | 1988 |
Effect of isolation on dopaminergic agonist-induced penile erections and stretching and yawning in male rats.
Topics: Animals; Apomorphine; Azepines; Brain; Injections, Intraperitoneal; Male; Motor Activity; Penile Erection; Rats; Rats, Inbred Strains; Receptors, Dopamine; Social Isolation; Yawning | 1988 |
Neurotensin reduces the affinity of D-2 dopamine receptors in rat striatal membranes.
Topics: Animals; Apomorphine; Cell Membrane; Corpus Striatum; Male; Neurotensin; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1987 |
A mosaic-like distribution of dopamine receptors in rat neostriatum and its relationship to striosomes.
Topics: Acetylcholinesterase; Animals; Apomorphine; Autoradiography; Corpus Striatum; Histocytochemistry; Rats; Receptors, Dopamine | 1987 |
Aporphine derivatives affect ocular function in diverse ways.
Topics: Animals; Apomorphine; Cats; Chemical Phenomena; Chemistry; Eye; Female; Intraocular Pressure; Male; Ocular Physiological Phenomena; Pupil; Rabbits; Sympathetic Nervous System | 1987 |
Effect of long-term dosing with tiapride on brain dopamine receptors and metabolism in rats. Comparative study with sulpiride and haloperidol.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antiparkinson Agents; Apomorphine; Benzamides; Brain Chemistry; Dopamine; Haloperidol; Homovanillic Acid; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Sulpiride; Tiapamil Hydrochloride | 1987 |
Ganglioside GM1 treatment prevents the effects of subacute exposure to toluene on N-[3H]propylnorapomorphine binding characteristics in rat striatal membranes.
Topics: Animals; Apomorphine; Corpus Striatum; G(M1) Ganglioside; Male; Membranes; Osmolar Concentration; Rats; Rats, Inbred Strains; Receptors, Dopamine; Time Factors; Toluene; Tritium | 1987 |
Autoradiographic localization and quantification of dopamine D2 receptors in normal human brain with [3H]N-n-propylnorapomorphine.
Topics: Aged; Apomorphine; Autoradiography; Binding, Competitive; Brain; Brain Chemistry; Brain Mapping; Caudate Nucleus; Female; Globus Pallidus; Humans; Kinetics; Male; Putamen; Receptors, Dopamine | 1986 |
Tracer and maximal specific binding of tritiated spiperone or N-n-propylnorapomorphine to quantify dopamine receptors in rat brain regions in vivo.
Topics: Animals; Apomorphine; Brain; Brain Mapping; Butyrophenones; Rats; Receptors, Dopamine; Spiperone | 1986 |
A stereochemical explanation of the dopamine agonist and antagonist activity of stereoisomeric pairs.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Apomorphine; Chemical Phenomena; Chemistry; Dopamine; Dopamine Antagonists; Molecular Conformation; Naphthalenes; Piperidines; Receptors, Dopamine; Stereoisomerism; Structure-Activity Relationship; Tetrahydronaphthalenes; Thermodynamics | 1986 |
Characterization of high-affinity dopamine D2 receptors and modulation of affinity states by guanine nucleotides in cholate-solubilized bovine striatal preparations.
Topics: Animals; Apomorphine; Binding, Competitive; Cattle; Cholic Acid; Cholic Acids; Computers; Corpus Striatum; Domperidone; Guanine Nucleotides; Guanylyl Imidodiphosphate; Haloperidol; Kinetics; Receptors, Dopamine; Solubility; Spiperone | 1986 |
Dopamine receptors are located on rods in bovine retina.
Topics: Animals; Apomorphine; Autoradiography; Cattle; Photoreceptor Cells; Receptors, Dopamine; Retina; Spiperone | 1986 |
Evidence for dopaminergic binding sites in the human adrenal cortex.
Topics: Adrenal Cortex; Adult; Aged; Apomorphine; Binding, Competitive; Bromocriptine; Domperidone; Dopamine; Epinephrine; Female; Humans; Ketanserin; Male; Metoclopramide; Middle Aged; Receptors, Dopamine; Spiperone; Sulpiride; Time Factors | 1986 |
In situ molecular size of agonist dopamine D-2 binding sites in rat striatum.
Topics: Animals; Apomorphine; Corpus Striatum; Dopamine; Guanosine Triphosphate; Kinetics; Male; Molecular Weight; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sodium Chloride; Spiperone | 1987 |
In vivo labeling of dopamine receptors: light microscopic localization at the cellular level by means of dipping autoradiography with the agonist (3H)N-n-propylnorapomorphine.
Topics: Animals; Apomorphine; Autoradiography; Cerebral Cortex; Corpus Striatum; Dopamine; Haloperidol; Male; Nucleus Accumbens; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1987 |
The effects of a long term dihydroergotoxine treatment on agonist and antagonist striatal dopamine binding sites are dose and age related.
Topics: Aging; Animals; Apomorphine; Binding, Competitive; Corpus Striatum; Dihydroergotoxine; Dose-Response Relationship, Drug; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1986 |
Evidence for the release of 1-methyl-4-phenylpyridinium (MPP+) from rat striatal neurons in vitro.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apomorphine; Corpus Striatum; Dopamine; Dopamine Antagonists; In Vitro Techniques; Isoquinolines; Male; Neurons; Piperazines; Potassium Chloride; Pyridinium Compounds; Rats; Sulpiride; Temperature; Time Factors | 1985 |
Conversion of dopamine D1 receptors from high to low affinity for dopamine.
Topics: Animals; Apomorphine; Benzazepines; Corpus Striatum; Dopamine; Flupenthixol; In Vitro Techniques; Rats; Receptors, Dopamine | 1985 |
N-methyl,N-propargyl-2-aminotetralins:novel dopamine agonists with monoamine oxidase inhibiting properties.
Topics: 4-Butyrolactone; Alkynes; Animals; Apomorphine; Brain; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Female; Humans; In Vitro Techniques; Mice; Monoamine Oxidase Inhibitors; Motor Activity; Naphthalenes; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reserpine; Stereotyped Behavior; Tetrahydronaphthalenes | 1985 |
Influence of cimetidine, ranitidine and imidazole on the behavioral effects of (+/-) N-n-propylnorapomorphine in male rats.
Topics: Animals; Apomorphine; Behavior, Animal; Cimetidine; Drug Interactions; Humans; Imidazoles; Male; Penis; Ranitidine; Rats; Rats, Inbred Strains; Reflex; Sexual Behavior, Animal; Stereotyped Behavior | 1985 |
Occupation of dopamine receptors by N-n-propylnorapomorphine or spiperone and acetylcholine levels in the rat striatum.
Topics: Acetylcholine; Animals; Apomorphine; Binding Sites; Butyrophenones; Corpus Striatum; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Time Factors | 1985 |
The continuity of dopamine receptor antagonism can dictate the long-term behavioural consequences of a mesolimbic infusion of dopamine.
Topics: Animals; Apomorphine; Behavior, Animal; Dopamine; Female; Injections; Injections, Intraperitoneal; Limbic System; Motor Activity; Nucleus Accumbens; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sulpiride; Time Factors | 1985 |
Synthesis and pharmacological evaluation of aromatic dihydroxylated spiro[indan-1,3'-pyrrolidine] and spiro[indan-2,2'-pyrrolidine] derivatives.
Topics: Animals; Apomorphine; Body Temperature; Chemical Phenomena; Chemistry; Corpus Striatum; Pyrrolidines; Rats; Receptors, Dopamine; Tetrahydronaphthalenes | 1985 |
S(+)Apomorphines. Selective inhibition of excitatory effects of dopamine injected into the limbic system of the rat.
Topics: Animals; Apomorphine; Corpus Striatum; Dopamine Antagonists; Limbic System; Male; Motor Activity; Nucleus Accumbens; Posture; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1985 |
Effects of discriminant and non-discriminant dopamine antagonists on in vivo accumulation of 3H-N-propyl-norapomorphine in mouse striatum and tuberculum olfactorium.
Topics: Animals; Apomorphine; Brain Chemistry; Corpus Striatum; Dopamine Antagonists; Dose-Response Relationship, Drug; Humans; Kinetics; Male; Mice; Olfactory Bulb; Stereotyped Behavior | 1985 |
Chronic treatment with clozapine, unlike haloperidol, does not induce changes in striatal D-2 receptor function in the rat.
Topics: Acetylcholine; Animals; Apomorphine; Body Weight; Clozapine; Corpus Striatum; Dibenzazepines; Haloperidol; Humans; Male; Mastication; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Thioxanthenes; Tritium | 1985 |
Behavioural pharmacology of imidazole, a potential antidepressant agent.
Topics: Aggression; Animals; Antidepressive Agents; Apomorphine; Azepines; Behavior, Animal; Body Temperature; Chickens; Clonidine; Drug Synergism; Imidazoles; Lethal Dose 50; Male; Mice; Motor Activity; Penile Erection; Rats; Rats, Inbred Strains; Sleep; Yohimbine | 1985 |
Aporphines. 8. Total synthesis and pharmacological evaluation of (plus or minus)-apomorphine, (plus or minus)-apocodeine, (plus or minus)-N-n-propylnorapomorphine, and (plus or minus)-N-n-propylnorapocodeine.
Topics: Animals; Apomorphine; Aporphines; Behavior, Animal; Cats; Dogs; Emetics; Haplorhini; Mice; Motor Activity; Nictitating Membrane; Optical Rotation; Propane; Stereoisomerism; Structure-Activity Relationship | 1973 |
Hypothermic effects of N-n-propylnorapomorphine in mice: antagonism by neurotransmitter receptor blockers.
Topics: Animals; Apomorphine; Body Temperature; Dose-Response Relationship, Drug; Humans; Male; Mice; Neurotransmitter Agents; Receptors, Drug; Stereotyped Behavior | 1980 |
Characterisation of the mechanisms by which purported dopamine agonists reduce spontaneous locomotor activity of mice.
Topics: Animals; Antipsychotic Agents; Apomorphine; Bromocriptine; Catecholamines; Dopamine; Dose-Response Relationship, Drug; Imidazolines; Male; Mice; Motor Activity; Prazosin; Receptors, Dopamine; Spiperone; Tetrahydronaphthalenes; Yohimbine | 1981 |
[3H]N-propylapomorphine and [3H]spiperone binding in brain indicate two states of the D2-dopamine receptor.
Topics: Animals; Antipsychotic Agents; Apomorphine; Brain; Butyrophenones; Catecholamines; Cattle; Caudate Nucleus; Cyclic AMP; Ergot Alkaloids; Guanosine Triphosphate; In Vitro Techniques; Kinetics; Receptors, Dopamine; Spiperone | 1982 |
Long-term adaptive changes in striatal dopamine function in response to chronic neuroleptic intake in rats.
Topics: Acetylcholine; Animals; Antipsychotic Agents; Apomorphine; Corpus Striatum; Glutamates; Glutamic Acid; Haloperidol; Rats; Receptors, Dopamine; Spiperone; Sulpiride | 1983 |
Studies on the mechanism of action of substituted benzamide drugs.
Topics: Animals; Antipsychotic Agents; Apomorphine; Benzamides; Brain; Catalepsy; Corpus Striatum; Humans; Hyperkinesis; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Substantia Nigra; Sulpiride; Tritium | 1984 |
l-Glutamate reduces the affinity of [3H]N-propylnorapomorphine binding sites in striatal membranes.
Topics: Animals; Antiparkinson Agents; Apomorphine; Aspartic Acid; Binding Sites; Cell Membrane; Corpus Striatum; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Spiperone | 1984 |
Mouse locomotor activity: an in vivo test for dopamine autoreceptor activation.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Benzazepines; Bromocriptine; Ergolines; Female; Methods; Mice; Motor Activity; Receptors, Dopamine; Sulpiride | 1984 |
Long-term consequences of antagonism by neuroleptics of behavioural events occurring during mesolimbic dopamine infusion.
Topics: Animals; Antiparkinson Agents; Antipsychotic Agents; Apomorphine; Dopamine; Dopamine Antagonists; Female; Haloperidol; Injections; Methysergide; Motor Activity; Nucleus Accumbens; Rats; Rats, Inbred Strains; Septal Nuclei; Sulpiride; Time Factors | 1984 |
Dopamine receptor binding sites in the rat superior colliculus.
Topics: Animals; Apomorphine; In Vitro Techniques; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Superior Colliculi | 1984 |
Remoxipride, a new potential antipsychotic compound with selective antidopaminergic actions in the rat brain.
Topics: Adenylyl Cyclases; Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Benzamides; Binding, Competitive; Brain Chemistry; Catalepsy; Chlorpromazine; Dogs; Female; Haloperidol; Histocytochemistry; Humans; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Remoxipride; Spiperone; Sulpiride; Thioridazine; Vomiting | 1984 |
Effect of GM1 ganglioside treatment on the recovery of dopaminergic nigro-striatal neurons after different types of lesion.
Topics: Animals; Apomorphine; Behavior, Animal; Corpus Striatum; G(M1) Ganglioside; Gangliosides; Hydroxydopamines; Nerve Regeneration; Neurons; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Rotation; Substantia Nigra; Tyrosine 3-Monooxygenase | 1984 |
Differential labelling of dopamine receptors in rat brain in vivo: comparison of [3H]piribedil, [3H]S 3608 and [3H]N,n-propylnorapomorphine.
Topics: Animals; Apomorphine; Brain; Butaclamol; Corpus Striatum; Female; Nucleus Accumbens; Piperazines; Piribedil; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1983 |
Correspondency between different affinity states and target size of the bovine striatal D2 dopamine receptor.
Topics: Acetylcholinesterase; Animals; Apomorphine; Butaclamol; Cattle; Cell Membrane; Corpus Striatum; Dopamine; Guanosine Triphosphate; Kinetics; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Sulpiride | 1983 |
High- and low-affinity states of striatal D2 receptors are not affected by 6-hydroxydopamine or chronic haloperidol treatment.
Topics: Animals; Apomorphine; Butaclamol; Cinanserin; Corpus Striatum; Dopamine; Guanylyl Imidodiphosphate; Haloperidol; Hydroxydopamines; Male; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1984 |
An orally effective, long-acting dopaminergic prodrug: (-)-10,11-methylenedioxy-N-propylnoraporphine.
Topics: Administration, Oral; Animals; Apomorphine; Brain; Cattle; Cyclic AMP; Humans; Rats; Receptors, Dopamine; Stereotyped Behavior | 1982 |
Potentiation of the aphrodisiac effect of N-n-propyl-norapomorphine by naloxone.
Topics: Adrenocorticotropic Hormone; Animals; Aphrodisiacs; Apomorphine; Dose-Response Relationship, Drug; Drug Synergism; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains | 1982 |
Cholecystokinin peptides in vitro modulate the characteristics of the striatal 3H-N-propylnorapomorphine sites.
Topics: Animals; Apomorphine; Cell Membrane; Corpus Striatum; Gastrins; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sincalide; Spiperone; Tetragastrin | 1983 |
Neurotensin in vitro markedly reduces the affinity in subcortical limbic 3H-N-propylnorapomorphine binding sites.
Topics: Animals; Apomorphine; Limbic System; Male; Neurotensin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Neurotensin; Receptors, Opioid | 1983 |
Subcortical limbic 3H-N-propylnorapomorphine binding sites are markedly modulated by cholecystokinin-8 in vitro.
Topics: Animals; Apomorphine; Cell Membrane; Kinetics; Male; Nucleus Accumbens; Olfactory Bulb; Rats; Rats, Inbred Strains; Receptors, Dopamine; Septal Nuclei; Sincalide; Specific Pathogen-Free Organisms | 1983 |
Neurotensin affects hyperactivity but not stereotypy induced by pre and post synaptic dopaminergic stimulation.
Topics: Amphetamine; Animals; Apomorphine; Dopamine; Humans; Hyperkinesis; Male; Neurotensin; Nomifensine; Rats; Rats, Inbred Strains; Stereotyped Behavior; Synaptic Transmission | 1983 |
In vivo binding of N-n-propylnorapomorphine in the rat brain: regional localization, quantification in striatum and lack of correlation with dopamine metabolism.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Binding Sites; Brain; Chemical Phenomena; Chemistry; Corpus Striatum; Dopamine; Homovanillic Acid; Hydroxydopamines; Male; Oxidopamine; Rats; Rats, Inbred Strains; Time Factors | 1983 |
Localization of [3H]N-propylnorapomorphine binding in mouse striatum.
Topics: Afferent Pathways; Animals; Apomorphine; Corpus Striatum; Frontal Lobe; Hydroxydopamines; Kainic Acid; Kinetics; Male; Mice; Mice, Inbred C57BL; Neural Pathways; Neurons; Oxidopamine; Receptors, Dopamine; Spiperone | 1983 |
Differential anatomical location of [3H]-N,n-propylnorapomorphine and [3H]-spiperone binding sites in the striatum and substantia nigra of the rat.
Topics: Animals; Apomorphine; Butyrophenones; Corpus Striatum; Female; Hydroxydopamines; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Substantia Nigra; Tritium | 1983 |
In vivo binding of N-n-propylnorapomorphine in the rat striatum: quantification after lesions produced by kainate, 6-hydroxydopamine and decortication.
Topics: Animals; Apomorphine; Cerebellum; Corpus Striatum; Decerebrate State; Hydroxydopamines; Kainic Acid; Kinetics; Male; Oxidopamine; Pyrrolidines; Rats; Rats, Inbred Strains | 1984 |
Differential effects of continuous administration for 1 year of haloperidol or sulpiride on striatal dopamine function in the rat.
Topics: Acetylcholine; Animals; Apomorphine; Body Weight; Corpus Striatum; Haloperidol; Humans; Kinetics; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Sulpiride | 1984 |
Differential alterations in striatal dopamine receptor sensitivity induced by repeated administration of clinically equivalent doses of haloperidol, sulpiride or clozapine in rats.
Topics: Animals; Apomorphine; Clozapine; Corpus Striatum; Dibenzazepines; Haloperidol; Humans; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Sulpiride | 1984 |
Chronic dihydroergotoxine treatment affects the number of dopamine recognition sites in rat striatum.
Topics: Animals; Antiparkinson Agents; Apomorphine; Butyrophenones; Corpus Striatum; Dihydroergotoxine; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Tritium | 1984 |
Dopaminergic inhibition of adenylate cyclase correlates with high affinity agonist binding to anterior pituitary D2 dopamine receptors.
Topics: Adenylyl Cyclase Inhibitors; Animals; Apomorphine; Colforsin; Diterpenes; Dopamine; Dose-Response Relationship, Drug; Female; Guanosine Triphosphate; Pituitary Gland, Anterior; Receptors, Dopamine; Sodium Fluoride; Swine; Tetrahydronaphthalenes | 1984 |
Further functional in vitro comparison of pre- and postsynaptic dopamine receptors in the rabbit caudate nucleus.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acetylcholine; Animals; Apomorphine; Benzazepines; Caudate Nucleus; Choline; Clonidine; Female; Male; Piperidines; Rabbits; Receptors, Dopamine | 1983 |
Turnover of specific [3H]spiperone and [3H]N,n-propylnorapomorphine binding sites in rat striatum following phenoxybenzamine administration.
Topics: Animals; Apomorphine; Binding Sites; Binding, Competitive; Butyrophenones; Corpus Striatum; Female; Kinetics; Phenoxybenzamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1983 |
A comparison of the behavioural consequences of chronic stimulation of dopamine receptors in the nucleus accumbens of rat brain effected by a continuous infusion or by single daily injections.
Topics: Animals; Apomorphine; Dopamine; Haloperidol; Male; Motor Activity; Nucleus Accumbens; Rats; Rats, Inbred Strains; Receptors, Dopamine; Septal Nuclei | 1983 |
Direct radioligand measurement of dopamine receptors in the anterior pituitary gland.
Topics: Animals; Apomorphine; Binding, Competitive; Cattle; Cell Membrane; Cells, Cultured; Ligands; Pituitary Gland, Anterior; Radioligand Assay; Receptors, Dopamine; Spiperone; Swine; Tritium | 1983 |
Aporphines. 48. Enantioselectivity of (R)-(-)- and (S)-(+)-N-n-propylnorapomorphine on dopamine receptors.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Chromatography, High Pressure Liquid; Circular Dichroism; Corpus Striatum; Humans; Male; Models, Molecular; Motor Activity; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereoisomerism; Stereotyped Behavior | 1983 |
Interaction of (+)- and (-)-3-PPP with the dopamine receptor in the anterior pituitary gland.
Topics: Animals; Apomorphine; Binding Sites; Cell Membrane; Depression, Chemical; In Vitro Techniques; Male; Methyltyrosines; Piperidines; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereoisomerism | 1984 |
Stimulation of dopamine autoreceptors elicits "premature ejaculation" in rats.
Topics: Animals; Apomorphine; Copulation; Domperidone; Dopamine Antagonists; Ejaculation; Female; Haloperidol; Lisuride; Male; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sexual Behavior, Animal | 1984 |
Increase in serum corticosterone concentration and decrease in hypothalamic epinephrine concentration by N-propylnorapomorphine in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Corticosterone; Epinephrine; Homovanillic Acid; Hypothalamus; Male; Rats; Rats, Inbred Strains; Spiperone | 1984 |
Autoradiographic localization of dopamine receptors in the spinal cord of the rat using [3H]-N-propylnorapomorphine.
Topics: Animals; Apomorphine; Autoradiography; Binding, Competitive; Male; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spinal Cord; Substantia Gelatinosa | 1984 |
Role of brain dopaminergic mechanisms in rodent aggressive behavior: influence of (+/-)N-n-propyl-norapomorphine on three experimental models.
Topics: Aggression; Animals; Apomorphine; Brain; Dopamine; Electric Stimulation; Humans; Male; Mice; Predatory Behavior; Rats; Social Isolation; Stereotyped Behavior | 1980 |
Behavioral facilitation following chronic administration of N-n-propylnorapomorphine.
Topics: Animals; Apomorphine; Dextroamphetamine; Drug Interactions; Humans; Male; Mice; Stereotyped Behavior; Time Factors | 1980 |
N-n-propyl-norapomorphine: an extremely potent stimulant of dopamine autoreceptors.
Topics: Animals; Apomorphine; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Dose-Response Relationship, Drug; Frontal Lobe; Male; Motor Activity; Neural Pathways; Nucleus Accumbens; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stimulation, Chemical; Substantia Nigra | 1982 |
Dopamine receptor sensitivity after chronic dopamine agonists. Striatal 3H-spiroperidol binding in mice after chronic administration of high doses of apomorphine, N-n-propylnorapomorphine and dextroamphetamine.
Topics: Animals; Apomorphine; Butyrophenones; Corpus Striatum; Dextroamphetamine; Humans; Male; Mice; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1982 |
Influence of lisuride on morphine withdrawal signs in the rat: a dopamine-mimetic effect.
Topics: Aggression; Animals; Apomorphine; Dopamine; Ergolines; Haloperidol; Humans; Lisuride; Male; Morphine Dependence; Naloxone; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Sulpiride | 1982 |
Regulation of ligand binding to pituitary D-2 dopaminergic receptors. Effects of divalent cations and functional group modification.
Topics: Animals; Apomorphine; Cations, Divalent; Cattle; Dose-Response Relationship, Drug; Ethylmaleimide; Hydroxymercuribenzoates; Kinetics; Male; Pituitary Gland, Anterior; Receptors, Dopamine; Spiperone | 1983 |
Dopamine receptor binding on intact cells. Absence of a high-affinity agonist-receptor binding state.
Topics: Animals; Apomorphine; Binding, Competitive; Cattle; Kinetics; Male; Pituitary Gland, Anterior; Receptors, Dopamine; Spiperone | 1983 |
Interactions of a partial ergoline with dopamine receptors in vivo and in vitro.
Topics: Animals; Apomorphine; Butyrophenones; Cell Membrane; Corpus Striatum; Ergolines; Male; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1983 |
Analysis of N-n-propylnorapomorphine in plasma and tissue by capillary gas chromatography--electron-capture detection.
Topics: Animals; Apomorphine; Brain; Brain Chemistry; Chromatography, Gas; Rats; Receptors, Dopamine; Trifluoroacetic Acid | 1983 |
Determination of apomorphine and N-n-propylnorapomorphine in plasma using high-performance liquid chromatography and fluorescence detection.
Topics: Apomorphine; Chromatography, High Pressure Liquid; Fluorescence; Humans | 1983 |
Stimulation of rat spontaneous locomotion by low doses of haloperidol and (-)-sulpiride: importance of animal selection and measurement technique.
Topics: Animals; Apomorphine; Dextroamphetamine; Female; Haloperidol; Motor Activity; Rats; Rats, Inbred Strains; Sulpiride | 1983 |
Multiple daily amphetamine administration decreases both [3H]agonist and [3H]antagonist dopamine receptor binding.
Topics: Animals; Apomorphine; Butyrophenones; Corpus Striatum; Dextroamphetamine; Dopamine; Humans; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1982 |
Behavioral effects of (-)10,11-methylenedioxy-N-n-propylnoraporphine, an orally effective long-acting agent active at central dopamine receptors, and analogous aporphines.
Topics: Administration, Oral; Animals; Apomorphine; Behavior, Animal; Dose-Response Relationship, Drug; Humans; Male; Proadifen; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereotyped Behavior; Structure-Activity Relationship | 1982 |
Tissue levels of N-n-propylnorapomorphine after treatment with (-)10,11-methylenedioxy-N-n-propylnoraporphine, an orally long-acting prodrug active at central dopamine receptors.
Topics: Animals; Apomorphine; Aporphines; Chromatography, High Pressure Liquid; Humans; Rats; Receptors, Dopamine; Stereotyped Behavior | 1982 |
Inhibition of nigral dopaminergic firing by N-n-propyl-norapomorphine: behavioural and biochemical correlates.
Topics: Action Potentials; Animals; Apomorphine; Dopamine; Humans; Male; Motor Activity; Rats; Rats, Inbred Strains; Stereotyped Behavior; Substantia Nigra | 1982 |
Effects of proteolytic enzymes and monovalent ions demonstrate protease-sensitive and protease-insensitive stereospecific binding sites on dopaminergic receptors in rat striatum.
Topics: Animals; Apomorphine; Cations, Monovalent; Corpus Striatum; Female; Haloperidol; In Vitro Techniques; Membranes; Peptide Hydrolases; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereoisomerism | 1982 |
Guanine nucleotides regulate both dopaminergic agonist and antagonist binding in porcine anterior pituitary.
Topics: Animals; Apomorphine; Binding, Competitive; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Kinetics; Pituitary Gland, Anterior; Receptors, Dopamine; Spiperone; Swine | 1982 |
Reinforcement with naloxone of N-n-propylnorapomorphine (NPA) capability for stimulating male rat copulatory behavior.
Topics: Animals; Apomorphine; Copulation; Dose-Response Relationship, Drug; Drug Interactions; Male; Naloxone; Rats; Rats, Inbred Strains; Sexual Behavior, Animal | 1982 |
Dopamine receptor of the porcine anterior pituitary gland. Evidence for two affinity states discriminated by both agonists and antagonists.
Topics: Animals; Apomorphine; Binding Sites; Binding, Competitive; Dopamine; Dopamine Antagonists; Female; Guanine Nucleotides; In Vitro Techniques; Pituitary Gland, Anterior; Receptors, Dopamine; Spiperone; Swine | 1982 |
Dopamine receptor of the porcine anterior pituitary gland. Effects of N-ethylmaleimide and heat on ligand binding mimic the effects of guanine nucleotides.
Topics: Animals; Apomorphine; Ethylmaleimide; Female; Guanine Nucleotides; Hot Temperature; In Vitro Techniques; Pituitary Gland, Anterior; Radioligand Assay; Receptors, Dopamine; Spiperone; Swine | 1982 |
Denervation in the dopaminergic mesolimbic system: functional changes followed using (-)N-n-propylnorapomorphine depend on the basal activity levels of rats.
Topics: Animals; Apomorphine; Denervation; Desipramine; Dopamine; Humans; Hydroxydopamines; Injections, Intraventricular; Limbic System; Male; Motor Activity; Rats; Stereotyped Behavior; Time Factors | 1980 |
Synthesis and dopaminergic properties of some exo- and endo-2-aminobenzonorbornenes designed as rigid analogue of dopamine.
Topics: Animals; Apomorphine; Binding, Competitive; Chemical Phenomena; Chemistry; Corpus Striatum; Dopamine; Humans; In Vitro Techniques; Injections; Male; Mice; Motor Activity; Norbornanes; Nucleus Accumbens; Rats; Stereotyped Behavior; Tetrahydronaphthalenes | 1982 |
Behavioural and biochemical consequences of persistent overstimulation of mesolimbic dopamine systems in the rat.
Topics: Animals; Apomorphine; Behavior, Animal; Dopamine; Dose-Response Relationship, Drug; Humans; Limbic System; Male; Mesencephalon; Motor Activity; Nucleus Accumbens; Rats; Rats, Inbred Strains; Stereotyped Behavior | 1982 |
Dopamine receptors in subcellular fractions from bovine caudate: enrichment of [3H]spiperone binding in a postsynaptic membrane fraction.
Topics: Animals; Apomorphine; Binding, Competitive; Butyrophenones; Cattle; Caudate Nucleus; Dopamine; In Vitro Techniques; Kinetics; Receptors, Dopamine; Spiperone; Subcellular Fractions; Synaptic Membranes | 1981 |
Kainate lesion dissociates striatal dopamine receptor radioligand binding sites.
Topics: Animals; Apomorphine; Benzimidazoles; Corpus Striatum; Domperidone; Flupenthixol; In Vitro Techniques; Kainic Acid; Male; Piperidines; Pyrrolidines; Radioligand Assay; Rats; Receptors, Dopamine; Spiperone | 1981 |
Parkinson's disease: new treatments.
Topics: Acetylcholine; Amantadine; Apomorphine; Bromocriptine; Carbidopa; Counseling; Dopamine; Humans; Levodopa; Monoamine Oxidase Inhibitors; Neurologic Manifestations; Parkinson Disease; Physical Therapy Modalities; Receptors, Dopamine; Thalamus | 1981 |
Characterization of normal and supersensitive dopamine receptors: effects of ergot drugs and neuropeptides.
Topics: Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Brain; Bromocriptine; Caudate Nucleus; Corpus Striatum; Ergolines; Kinetics; Organ Specificity; Pergolide; Putamen; Rats; Receptors, Dopamine | 1981 |
Regional in vivo binding of [3H]N-propylnorapomorphine in the mouse brain. Evidence for labelling of central dopamine receptors.
Topics: Animals; Apomorphine; Brain; Chromatography, Thin Layer; Male; Mice; Receptors, Dopamine | 1981 |
Dopamine receptor binding in bovine intermediate lobe pituitary membranes.
Topics: Animals; Apomorphine; Butyrophenones; Catecholamines; Cattle; Cell Membrane; Guanosine Triphosphate; Phenothiazines; Pituitary Gland; Receptors, Dopamine; Spiperone | 1980 |
Different dopaminergic mechanisms for amfonelic acid, amphetamine and apomorphine.
Topics: Amphetamine; Animals; Apomorphine; Discrimination Learning; Male; Nalidixic Acid; Naphthyridines; Rats; Receptors, Dopamine | 1980 |
The D2 dopamine receptor mediates inhibition of growth in GH4ZR7 cells: involvement of protein kinase-C epsilon.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Alprenolol; Animals; Apomorphine; Benzazepines; Butaclamol; Carcinogens; Cell Division; Cell Line; DNA; Dopamine; Ergolines; Humans; Isoenzymes; Kinetics; Norepinephrine; Pertussis Toxin; Phorbol Esters; Pituitary Neoplasms; Protein Kinase C; Quinpirole; Receptors, Dopamine D2; Salicylamides; Spiperone; Thymidine; Transfection; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1994 |
Cholecystokinin octapeptide in vitro and ex vivo strongly modulates striatal dopamine D2 receptors in rat forebrain sections.
Topics: Animals; Apomorphine; Autoradiography; Dopamine; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Nucleus Accumbens; Prosencephalon; Putamen; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Sincalide; Sulpiride | 1995 |
Drug-induced up-regulation of dopamine D2 receptors on cultured cells.
Topics: Animals; Apomorphine; Dopamine Agonists; Dopamine Antagonists; Down-Regulation; Ergolines; Macaca mulatta; Quinpirole; Receptors, Dopamine D2; Tumor Cells, Cultured; Up-Regulation | 1995 |
Behavioral effects of the reversible dopamine antagonist flupenthixol are not potentiated by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline in the preweanling rat.
Topics: Animals; Apomorphine; Behavior, Animal; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Female; Flupenthixol; Grooming; Injections, Intraperitoneal; Male; Quinolines; Rats; Rats, Sprague-Dawley; Stereotyped Behavior | 1995 |
Ontogeny of behavioral sensitization in the rat: effects of direct and indirect dopamine agonists.
Topics: Aging; Amphetamine; Animals; Apomorphine; Behavior, Animal; Dopamine Agonists; Female; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Stereotyped Behavior | 1994 |
Alternative splicing of the dopamine D2 receptor directs specificity of coupling to G-proteins.
Topics: Adenylyl Cyclase Inhibitors; Alternative Splicing; Amino Acid Sequence; Animals; Apomorphine; Base Sequence; Cell Line; Cloning, Molecular; Cyclic AMP; Dopamine; Dopamine Agonists; GTP-Binding Proteins; Humans; Isoproterenol; Kinetics; Mice; Molecular Sequence Data; Mutagenesis, Insertional; Receptors, Adrenergic, beta-2; Receptors, Dopamine D2; Recombinant Proteins; Spiperone; Transfection | 1995 |
Modulation of the clozapine structure increases its selectivity for the dopamine D4 receptor.
Topics: Apomorphine; Binding, Competitive; Cells, Cultured; Clozapine; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Humans; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D4; Spiperone; Structure-Activity Relationship | 1995 |
Chronic nicotine treatment counteracts dopamine D2 receptor upregulation induced by a partial meso-diencephalic hemitransection in the rat.
Topics: Animals; Apomorphine; Autoradiography; Carbachol; Diencephalon; Dopamine Agonists; Ligands; Male; Mesencephalon; Nicotine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Nicotinic; Up-Regulation | 1994 |
Caffeine cross-tolerance to selective dopamine D1 and D2 receptor agonists but not to their synergistic interaction.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Administration, Oral; Analysis of Variance; Animals; Apomorphine; Caffeine; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Synergism; Drug Tolerance; Ergolines; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Motor Activity; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2 | 1994 |
Effects of aporphine isomers on rat prolactin.
Topics: Animals; Apomorphine; Aporphines; Dopamine Agonists; Haloperidol; Male; Prolactin; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Stereoisomerism | 1994 |
Possible genetic factors underlying the pathophysiology of tardive dyskinesia.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antiparkinson Agents; Apomorphine; Cyclic AMP; Dyskinesia, Drug-Induced; Female; Fluphenazine; In Vitro Techniques; Male; Neostriatum; Rats; Rats, Sprague-Dawley; Stereotyped Behavior | 1994 |
Altered spontaneous behavior and sensitivity to apomorphine in rats following pretreatment with S(+)-aporphines or fluphenazine.
Topics: Animals; Apomorphine; Aporphines; Behavior, Animal; Dopamine Antagonists; Fluphenazine; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Stereotyped Behavior | 1993 |
A novel method for rapid enrichment of lactotrophs from dispersed anterior pituitary cells of the rat.
Topics: Amino Acid Sequence; Animals; Antibodies; Apomorphine; Cell Adhesion; Cells, Cultured; Cytological Techniques; Dopamine Agents; Male; Molecular Sequence Data; Pituitary Gland, Anterior; Polystyrenes; Prolactin; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2 | 1993 |
Cholecystokinin receptor subtypes regulate dopamine D2 receptors in rat neostriatal membranes. Involvement of D1 receptors.
Topics: Animals; Apomorphine; Cell Membrane; Dopamine Agents; Kinetics; Neostriatum; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Receptors, Dopamine D1; Receptors, Dopamine D2; Salicylamides; Sincalide | 1994 |
Receptor affinities of aporphine enantiomers in rat brain tissue.
Topics: Animals; Apomorphine; Aporphines; Brain; Dopamine Agents; In Vitro Techniques; Male; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Neurotransmitter; Stereoisomerism | 1994 |
Dopamine D2 receptor agonists: an analysis of indirect models.
Topics: Animals; Apomorphine; Binding, Competitive; Cattle; Dopamine Agents; In Vitro Techniques; Models, Chemical; Molecular Conformation; Neostriatum; Receptors, Dopamine D2; Spiperone | 1994 |
Dopamine D1 receptors are involved in the modulation of D2 receptors induced by cholecystokinin receptor subtypes in rat neostriatal membranes.
Topics: Animals; Apomorphine; Benzazepines; Binding, Competitive; Dopamine; Dopamine Agonists; In Vitro Techniques; Kinetics; Male; Membranes; Neostriatum; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Receptors, Dopamine D1; Receptors, Dopamine D2; Salicylamides; Sincalide | 1994 |
Mechanisms of up-regulation of D2L dopamine receptors by agonists and antagonists in transfected HEK-293 cells.
Topics: Apomorphine; Cell Line; Cyclic AMP; Cycloheximide; Dopamine Agonists; Dopamine Antagonists; Humans; Receptors, Dopamine D2; RNA, Messenger; Transfection; Up-Regulation; Virulence Factors, Bordetella | 1994 |
Modulation by estradiol and progesterone of the GTP effect on striatal D-2 dopamine receptors.
Topics: Animals; Apomorphine; Binding, Competitive; Corpus Striatum; Dopamine; Dopamine Agents; Estradiol; Female; Guanosine Triphosphate; In Vitro Techniques; Male; Ovariectomy; Progesterone; Rats; Receptors, Dopamine D2; Spiperone | 1993 |
Persistent effects of subchronic toluene exposure on spatial learning and memory, dopamine-mediated locomotor activity and dopamine D2 agonist binding in the rat.
Topics: Administration, Inhalation; Animals; Apomorphine; Behavior, Animal; Dopamine Agents; Learning; Male; Memory; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Toluene | 1993 |
Inhibition of substantia nigra dopamine cell firing by R(-)-N-n-propylnorapomorphine: electrophysiological and autoradiographic studies after regional inactivation of dopamine receptors by microinjection of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline.
Topics: Action Potentials; Animals; Apomorphine; Autoradiography; Dopamine Agents; Male; Microinjections; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Substantia Nigra | 1993 |
Paradoxical regulation of dopamine receptors in transfected 293 cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Apomorphine; Cell Line; Colforsin; Corpus Striatum; Cyclic AMP; DNA; Dopamine; Dopamine Agents; Dopamine Antagonists; Humans; Isoproterenol; Radioligand Assay; Rats; Receptors, Dopamine D2; Transfection | 1993 |
Dopamine D4 versus D2 receptor selectivity of dopamine receptor antagonists: possible therapeutic implications.
Topics: Animals; Apomorphine; Butyrophenones; Cell Line; Chlorpromazine; Clozapine; Dopamine Agents; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Haloperidol; Raclopride; Radioligand Assay; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D4; Salicylamides; Trifluoperazine | 1993 |
Monoamine oxidase inhibitors inhibit [3H]quinpirole binding in rat striatal membranes.
Topics: Animals; Apomorphine; Binding, Competitive; Corpus Striatum; Dopamine Agents; Ergolines; In Vitro Techniques; Kinetics; Male; Membranes; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenazocine; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, sigma; Spiperone | 1993 |
Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes.
Topics: Animals; Apomorphine; Cell Membrane; Dopamine Agents; Kinetics; Male; Neostriatum; Neurotensin; Peptide Fragments; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Neurotensin; Receptors, Neurotransmitter; Specific Pathogen-Free Organisms | 1993 |
Ontogenetic differences in the effects of EEDQ on dopamine-mediated behaviors.
Topics: Aging; Animals; Apomorphine; Behavior, Animal; Benzazepines; Dopamine; Dopamine Agents; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; Male; Motor Activity; Quinolines; Rats; Rats, Sprague-Dawley; Stereotyped Behavior | 1993 |
Identification of novel catecholamine absorbing proteins in the central nervous system.
Topics: Animals; Apomorphine; Binding, Competitive; Brain; Carrier Proteins; Catecholamines; Cattle; Corpus Striatum; Dopamine; Electrophoresis, Polyacrylamide Gel; Intracellular Membranes; Ligands; Mitochondria; Molecular Weight; Nerve Tissue Proteins; Organ Specificity; Rats; Rats, Sprague-Dawley; Synaptosomes; Tetrahydronaphthalenes | 1993 |
Specific induction of a functional endogenous D2 short dopamine receptor in GH4C1 cells.
Topics: Animals; Apomorphine; Base Sequence; Colforsin; Cyclic AMP; Dopamine; Dose-Response Relationship, Drug; Ergolines; Gene Expression; Kanamycin Kinase; Kinetics; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphotransferases; Pituitary Neoplasms; Polymerase Chain Reaction; Potassium Chloride; Prolactin; Quinpirole; Rats; Receptors, Dopamine D2; Recombinant Fusion Proteins; Spiperone; Sulpiride; Transfection; Tumor Cells, Cultured; Vasoactive Intestinal Peptide | 1993 |
Nafadotride, a potent preferential dopamine D3 receptor antagonist, activates locomotion in rodents.
Topics: Animals; Apomorphine; Cell Line; CHO Cells; Corpus Striatum; Cricetinae; Dopamine Agonists; Dopamine Antagonists; Humans; Limbic System; Male; Mice; Mitosis; Motor Activity; Naphthalenes; Pyrrolidines; Rats; Receptors, Dopamine D2; Receptors, Dopamine D3; Tumor Cells, Cultured | 1995 |
Ontogeny of dopamine agonist-induced sensitization: role of NMDA receptors.
Topics: Amphetamine; Animals; Animals, Suckling; Apomorphine; Dizocilpine Maleate; Dopamine Agonists; Excitatory Amino Acid Antagonists; Female; Male; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stereotyped Behavior | 1997 |
Possible involvement of G-proteins in the regulation of striatal dopamine D2 receptor affinity by cholecystokinin octapeptide.
Topics: Animals; Apomorphine; Dopamine Agonists; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Male; Membranes; Neostriatum; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Sincalide | 1997 |
Perinatal asphyxia induces long-term changes in dopamine D1, D2, and D3 receptor binding in the rat brain.
Topics: Animals; Apomorphine; Asphyxia Neonatorum; Benzazepines; Brain; Cesarean Section; Dopamine Agonists; Female; Humans; Infant, Newborn; Iodine Radioisotopes; Organ Specificity; Pregnancy; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; Spiperone; Sulpiride | 1997 |
Long-term effects of S(+)N-n-propylnorapomorphine compared with typical and atypical antipsychotics: differential increases of cerebrocortical D2-like and striatolimbic D4-like dopamine receptors.
Topics: Animals; Antipsychotic Agents; Apomorphine; Autoradiography; Cell Line; Cerebral Cortex; Clozapine; Dopamine Agonists; Drug Design; Fluphenazine; Limbic System; Male; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D4 | 1997 |
Lack of autoreceptor-mediated inhibitory control of dopamine release in striatal synaptosomes of D2 receptor-deficient mice.
Topics: 4-Aminopyridine; Amphetamine; Animals; Apomorphine; Autoreceptors; Benzopyrans; Cocaine; Corpus Striatum; Dopamine; Dopamine Agonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Fluoresceins; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Neural Inhibition; Oxazines; Potassium Chloride; Presynaptic Terminals; Quinpirole; Receptors, Dopamine D2; Synaptosomes; Tritium | 1998 |
[Inhibition of voltage-dependent K+ currents in rat C6 glioma cells by haloperidol and R(-)-NPA].
Topics: Animals; Apomorphine; Biological Transport, Active; Brain Neoplasms; Dopamine Agonists; Dopamine Antagonists; Glioma; Haloperidol; Potassium Channels; Rats; Tumor Cells, Cultured | 1997 |
Increased site-specific phosphorylation of tyrosine hydroxylase accompanies stimulation of enzymatic activity induced by cessation of dopamine neuronal activity.
Topics: 4-Butyrolactone; Animals; Apomorphine; Binding Sites; Cerebral Cortex; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Enzyme Activation; GABA Modulators; Hydroxylation; In Vitro Techniques; Male; Neurons; Phosphorylation; Rats; Rats, Sprague-Dawley; Tyrosine; Tyrosine 3-Monooxygenase | 1999 |
Enhanced striatal dopamine D(2) receptor-induced [35S]GTPgammaS binding after haloperidol treatment.
Topics: Animals; Apomorphine; Binding, Competitive; Catalepsy; Corpus Striatum; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Male; Rats; Rats, Wistar; Receptors, Dopamine D2; Spiperone; Sulfur Radioisotopes; Tritium; Up-Regulation | 1999 |
Dopamine receptor-modulated [35S]GTPgammaS binding in striatum of 6-hydroxydopamine-lesioned rats.
Topics: Animals; Apomorphine; Benzazepines; Bromocriptine; Cell Membrane; Corpus Striatum; Domperidone; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Ligands; Male; Oxidopamine; Piperazines; Quinpirole; Rats; Rats, Wistar; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Sulfur Radioisotopes; Tritium | 1999 |
In vivo venodilator action of fenoldopam, a dopamine D(1)-receptor agonist.
Topics: Animals; Apomorphine; Blood Pressure; Cardiac Output; Dopamine Agonists; Dose-Response Relationship, Drug; Fenoldopam; Ganglionic Blockers; Male; Mecamylamine; Pressoreceptors; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Vascular Resistance; Vasodilator Agents | 2000 |
Behavioral activation induced by D(2)-like receptor stimulation during opiate withdrawal.
Topics: Analgesics, Opioid; Animals; Apomorphine; Behavior, Animal; Dopamine Agonists; Dopamine Antagonists; Drug Synergism; Locomotion; Male; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Stereotyped Behavior; Substance Withdrawal Syndrome | 2000 |
Expression of fos-related antigens in the nucleus accumbens during opiate withdrawal and their attenuation by a D2 dopamine receptor agonist.
Topics: Animals; Apomorphine; Behavior, Animal; Dopamine Agonists; Dopamine Antagonists; Immunohistochemistry; Lithium Chloride; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nucleus Accumbens; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Substance Withdrawal Syndrome | 2000 |
(-)-N-[(11)C]propyl-norapomorphine: a positron-labeled dopamine agonist for PET imaging of D(2) receptors.
Topics: Animals; Apomorphine; Binding, Competitive; Carbon Radioisotopes; Cerebellum; Corpus Striatum; Dopamine Agonists; Dopamine Antagonists; Haloperidol; Magnetic Resonance Imaging; Male; Organometallic Compounds; Papio; Propionates; Radioactive Tracers; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Sensitivity and Specificity; Tissue Distribution; Tomography, Emission-Computed | 2000 |
Receptor crosstalk protein, calcyon, regulates affinity state of dopamine D1 receptors.
Topics: Apomorphine; Benzazepines; Binding, Competitive; Carbachol; Cell Line; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Guanosine Triphosphate; Humans; Membrane Proteins; Radioligand Assay; Receptor Cross-Talk; Receptors, Dopamine D1; Tritium | 2001 |
Agonist-independent and -dependent oligomerization of dopamine D(2) receptors by fusion to fluorescent proteins.
Topics: Animals; Apomorphine; Bacterial Proteins; Benzamides; CHO Cells; COS Cells; Cricetinae; Dopamine Agonists; Dopamine Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Luminescent Proteins; Protein Structure, Quaternary; Receptors, Dopamine D2; Recombinant Fusion Proteins; Transfection | 2001 |
Specific binding of [(11)C]raclopride and N-[(3)H]propyl-norapomorphine to dopamine receptors in living mouse striatum: occupancy by endogenous dopamine and guanosine triphosphate-free G protein.
Topics: Animals; Apomorphine; Carbon Radioisotopes; Corpus Striatum; Dopamine; GTP-Binding Proteins; Kinetics; Male; Mice; Protein Binding; Raclopride; Receptors, Dopamine; Tritium | 2002 |
Reversible and irreversible components of [(3)H]-N-propylnorapomorphine interaction with rat striatal membranes.
Topics: Animals; Antioxidants; Apomorphine; Ascorbic Acid; Binding Sites; Binding, Competitive; Cell Membrane; Dithiothreitol; Dopamine; Kinetics; Neostriatum; Oxidation-Reduction; Radioactive Tracers; Rats; Receptors, Dopamine; Tritium | 2002 |
Endogenous RGS proteins facilitate dopamine D(2S) receptor coupling to G(alphao) proteins and Ca2+ responses in CHO-K1 cells.
Topics: Animals; Apomorphine; Calcium Signaling; CHO Cells; Cricetinae; Dopamine; GTP-Binding Protein alpha Subunits, Gi-Go; Heterotrimeric GTP-Binding Proteins; Humans; Pertussis Toxin; Receptors, Dopamine D2; Recombinant Proteins; RGS Proteins; Signal Transduction | 2003 |
Iso-lactam and reduced amide analogues of the peptidomimetic dopamine receptor modulator 3(R)-[(2(S)-pyrrolidinylcarbonyl)amino]-2-oxo-1-pyrrolidineacetamide.
Topics: Animals; Apomorphine; Cattle; Cell Membrane; Corpus Striatum; Dopamine Agents; In Vitro Techniques; Lactams; Molecular Mimicry; Protein Binding; Pyrrolidinones; Radioligand Assay; Receptors, Dopamine; Structure-Activity Relationship | 2003 |
Constitutive oligomerization of human D2 dopamine receptors expressed in Spodoptera frugiperda 9 (Sf9) and in HEK293 cells. Analysis using co-immunoprecipitation and time-resolved fluorescence resonance energy transfer.
Topics: Animals; Apomorphine; Base Sequence; Blotting, Western; Cell Membrane; Cells, Cultured; Dopamine Agonists; Dopamine Antagonists; Epitopes; Europium; Fluorescence Resonance Energy Transfer; Humans; Immunoglobulins; Ligands; Molecular Sequence Data; Precipitin Tests; Raclopride; Receptors, Dopamine D2; Recombinant Proteins; Spodoptera; Time Factors | 2003 |
Quantitative analysis of (-)-N-(11)C-propyl-norapomorphine in vivo binding in nonhuman primates.
Topics: Animals; Apomorphine; Binding Sites; Brain; Carbon Radioisotopes; Dopamine Agonists; Magnetic Resonance Imaging; Male; Papio; Radioactive Tracers; Receptors, Dopamine D2; Time Factors; Tomography, Emission-Computed | 2004 |
In vivo vulnerability to competition by endogenous dopamine: comparison of the D2 receptor agonist radiotracer (-)-N-[11C]propyl-norapomorphine ([11C]NPA) with the D2 receptor antagonist radiotracer [11C]-raclopride.
Topics: Algorithms; Amphetamine; Animals; Apomorphine; Binding, Competitive; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Papio; Raclopride; Radiopharmaceuticals; Receptors, Dopamine D2; Tomography, Emission-Computed | 2004 |
Investigation of the mechanism of agonist and inverse agonist action at D2 dopamine receptors.
Topics: Animals; Apomorphine; Binding, Competitive; Butaclamol; CHO Cells; Cricetinae; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Receptors, Dopamine D2; Spiperone; Sulfur Radioisotopes; Tritium | 2004 |
Effects of the intravitreal administration of dopaminergic ligands on the b-wave amplitude of the rabbit electroretinogram.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Benzazepines; Dopamine; Dopamine Agonists; Dopamine Antagonists; Electroretinography; Ligands; Photic Stimulation; Rabbits; Receptors, Dopamine D1; Receptors, Dopamine D2; Sulpiride | 2005 |
Design, synthesis and evaluation of a PLG tripeptidomimetic based on a pyridine scaffold.
Topics: Acetamides; Animals; Apomorphine; Crystallography, X-Ray; Dopamine Agents; Drug Synergism; Humans; Hydrogen Bonding; Mice; Models, Molecular; Molecular Mimicry; Molecular Structure; MSH Release-Inhibiting Hormone; NIH 3T3 Cells; Protein Structure, Secondary; Pyridines; Receptors, Dopamine D2; Structure-Activity Relationship | 2004 |
Mechanisms of inverse agonist action at D2 dopamine receptors.
Topics: Animals; Apomorphine; CHO Cells; Cricetinae; Cricetulus; Dopamine D2 Receptor Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Ligands; Protein Binding; Radioligand Assay; Receptors, Dopamine D2; Tritium | 2005 |
Effects of dopamine, SKF-38393 and R(-)-NPA on ATP-activated currents in rat DRG neurons.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenosine Triphosphate; Animals; Apomorphine; Dopamine; Ganglia, Spinal; Guanosine Diphosphate; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Membrane Potentials; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Signal Transduction; Thionucleotides | 2005 |
A preliminary PET evaluation of the new dopamine D2 receptor agonist [11C]MNPA in cynomolgus monkey.
Topics: Animals; Apomorphine; Brain; Feasibility Studies; Macaca fascicularis; Pilot Projects; Positron-Emission Tomography; Radiopharmaceuticals; Receptors, Dopamine D2; Tissue Distribution | 2005 |
Measurement of the proportion of D2 receptors configured in state of high affinity for agonists in vivo: a positron emission tomography study using [11C]N-propyl-norapomorphine and [11C]raclopride in baboons.
Topics: Animals; Apomorphine; Brain; Carbon Radioisotopes; Dopamine Agonists; Male; Papio; Positron-Emission Tomography; Raclopride; Receptors, Dopamine D2 | 2005 |
Subchronic intermittent caffeine administration to unilaterally 6-hydroxydopamine-lesioned rats sensitizes turning behaviour in response to dopamine D(1) but not D(2) receptor agonists.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Caffeine; Central Nervous System Stimulants; Dopamine Agents; Dopamine Agonists; Levodopa; Male; Oxidopamine; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Stereotyped Behavior; Sympathectomy, Chemical; Sympatholytics | 2005 |
Amphetamine-induced dopamine release: duration of action as assessed with the D2/3 receptor agonist radiotracer (-)-N-[(11)C]propyl-norapomorphine ([11C]NPA) in an anesthetized nonhuman primate.
Topics: Amphetamine; Animals; Apomorphine; Binding, Competitive; Carbon Isotopes; Corpus Striatum; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Male; Papio; Positron-Emission Tomography; Raclopride; Time Factors | 2007 |
Modulation of heroin and cocaine self-administration by dopamine D1- and D2-like receptor agonists in rhesus monkeys.
Topics: Animals; Apomorphine; Behavior, Animal; Benzazepines; Cocaine; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Synergism; Female; Heroin; Injections, Intravenous; Macaca mulatta; Male; Narcotics; Quinpirole; Receptors, Dopamine D1; Receptors, Dopamine D2; Reinforcement, Psychology; Self Administration; Vasoconstrictor Agents | 2007 |
Synthesis and evaluation of novel pyridine based PLG tripeptidomimetics.
Topics: Animals; Apomorphine; Dose-Response Relationship, Drug; Humans; Iodide Peroxidase; Iodothyronine Deiodinase Type II; Ligands; Mice; Molecular Mimicry; Molecular Structure; MSH Release-Inhibiting Hormone; NIH 3T3 Cells; Pyridines; Stereoisomerism; Structure-Activity Relationship | 2008 |
Characterization of functional roles of DRY motif in the 2nd intracellular loop of dopamine D2 and D3 receptors.
Topics: Amino Acid Motifs; Apomorphine; Arginine; Aspartic Acid; Cell Line; Cell Membrane; Cyclic AMP; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Humans; Mutation; Protein Conformation; Protein Structure, Tertiary; Protein Transport; Quinpirole; Receptors, Dopamine D2; Receptors, Dopamine D3; Signal Transduction; Spiperone; Sulpiride; Transfection | 2008 |
Effects of dorsal striatal infusions of R(-)-propylnorapomorphine on kappa-opioid-mediated locomotor activity in the young rat: possible role of the indirect pathway.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Animals, Newborn; Apomorphine; Behavior, Animal; Corpus Striatum; Dopamine Agonists; Dose-Response Relationship, Drug; Globus Pallidus; Motor Activity; Neural Pathways; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Subthalamic Nucleus | 2008 |
Dopamine D(2/3) receptor occupancy of apomorphine in the nonhuman primate brain--a comparative PET study with [11C]raclopride and [11C]MNPA.
Topics: Animals; Apomorphine; Brain; Carbon Radioisotopes; Dopamine D2 Receptor Antagonists; Female; Macaca fascicularis; Positron-Emission Tomography; Protein Binding; Raclopride; Receptors, Dopamine D2; Receptors, Dopamine D3; Tissue Distribution | 2009 |
Quantitative PET analysis of the dopamine D2 receptor agonist radioligand 11C-(R)-2-CH3O-N-n-propylnorapomorphine in the human brain.
Topics: Adult; Apomorphine; Brain; Dopamine D2 Receptor Antagonists; Humans; Image Interpretation, Computer-Assisted; Male; Metabolic Clearance Rate; Positron-Emission Tomography; Radiopharmaceuticals; Receptors, Dopamine D2; Tissue Distribution; Young Adult | 2009 |
Human biodistribution and dosimetry of the D2/3 agonist 11C-N-propylnorapomorphine (11C-NPA) determined from PET.
Topics: Apomorphine; Body Burden; Carbon Radioisotopes; Dopamine D2 Receptor Antagonists; Female; Humans; Male; Metabolic Clearance Rate; Organ Specificity; Positron-Emission Tomography; Radiometry; Radiopharmaceuticals; Receptors, Dopamine D2; Receptors, Dopamine D3; Tissue Distribution; Whole-Body Counting | 2009 |
Advancement in PET quantification using 3D-OP-OSEM point spread function reconstruction with the HRRT.
Topics: Algorithms; Animals; Apomorphine; Brain; Carbon Radioisotopes; Dopamine Agonists; Dopamine Antagonists; Fluorine Radioisotopes; Humans; Image Processing, Computer-Assisted; Macaca fascicularis; Models, Statistical; Phantoms, Imaging; Positron-Emission Tomography; Raclopride; Radiopharmaceuticals | 2009 |
The A(2B)-D(2) receptor interaction that controls carotid body catecholamines release locates between the last two steps of hypoxic transduction cascade.
Topics: Adenosine-5'-(N-ethylcarboxamide); Animals; Apomorphine; Carotid Body; Catecholamines; Dopamine Agonists; Female; Hypoxia; In Vitro Techniques; Ionomycin; Male; Rats; Rats, Wistar; Receptor, Adenosine A2B; Receptors, Dopamine D2; Signal Transduction | 2009 |
Measurement error analysis for the determination of dopamine D(2) receptor occupancy using the agonist radioligand [(11)C]MNPA.
Topics: Algorithms; Antipsychotic Agents; Apomorphine; Cerebellum; Computer Simulation; Data Interpretation, Statistical; Humans; Kinetics; Least-Squares Analysis; Male; Models, Statistical; Positron-Emission Tomography; Radiopharmaceuticals; Receptors, Dopamine D2; Risperidone; Young Adult | 2010 |
Co-operativity in agonist binding at the D2 dopamine receptor: evidence from agonist dissociation kinetics.
Topics: Animals; Apomorphine; Brain; CHO Cells; Cricetinae; Cricetulus; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Protein Binding; Radioligand Assay; Rats; Rats, Wistar; Receptors, Dopamine D2; Tissue Distribution; Tritium | 2010 |
A comparative evaluation of the dopamine D(2/3) agonist radiotracer [11C](-)-N-propyl-norapomorphine and antagonist [11C]raclopride to measure amphetamine-induced dopamine release in the human striatum.
Topics: Adult; Amphetamine; Apomorphine; Carbon Radioisotopes; Corpus Striatum; Dopamine; Dopamine Agonists; Dopamine Antagonists; Female; Humans; Male; Middle Aged; Positron-Emission Tomography; Raclopride; Young Adult | 2010 |
Dopamine beta-hydroxylase-deficient mice have normal densities of D(2) dopamine receptors in the high-affinity state based on in vivo PET imaging and in vitro radioligand binding.
Topics: Animals; Apomorphine; Binding, Competitive; Cerebellum; Dopamine Agonists; Dopamine beta-Hydroxylase; Female; Kinetics; Male; Mice; Mice, Knockout; Neostriatum; Positron-Emission Tomography; Radioligand Assay; Radiopharmaceuticals; Receptors, Dopamine D2; Spiperone | 2010 |
D2 receptor occupancy in conscious rat brain is not significantly distinguished with [3H]-MNPA, [3H]-(+)-PHNO, and [3H]-raclopride.
Topics: Animals; Apomorphine; Binding Sites; Binding, Competitive; Brain; CHO Cells; Cricetinae; Cricetulus; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Male; Oxazines; Raclopride; Rats; Rats, Long-Evans; Receptors, Dopamine D2; Receptors, G-Protein-Coupled | 2010 |
Effects of unilateral 6-OHDA lesions on [3H]-N-propylnorapomorphine binding in striatum ex vivo and vulnerability to amphetamine-evoked dopamine release in rat.
Topics: Amphetamine; Animals; Apomorphine; Binding, Competitive; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agonists; Dopamine Uptake Inhibitors; Male; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley | 2011 |
Test-retest reproducibility of dopamine D2/3 receptor binding in human brain measured by PET with [11C]MNPA and [11C]raclopride.
Topics: Adult; Apomorphine; Brain; Data Interpretation, Statistical; Humans; Male; Positron-Emission Tomography; Raclopride; Radiopharmaceuticals; Receptors, Dopamine D2; Receptors, Dopamine D3; Reproducibility of Results | 2013 |
Development of 7TM receptor-ligand complex models using ligand-biased, semi-empirical helix-bundle repacking in torsion space: application to the agonist interaction of the human dopamine D2 receptor.
Topics: Animals; Apomorphine; Binding Sites; Cattle; Humans; Ligands; Molecular Docking Simulation; Protein Binding; Protein Conformation; Protein Structure, Secondary; Receptors, Dopamine D2; Rhodopsin | 2013 |
Behavioral effects of dopamine receptor inactivation in the caudate-putamen of preweanling rats: role of the D2 receptor.
Topics: Aging; Alkylating Agents; Animals; Apomorphine; Benzazepines; Caudate Nucleus; Dimethyl Sulfoxide; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Female; Lisuride; Male; Motor Activity; Putamen; Quinolines; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Weaning | 2014 |
Behavioral effects of dopamine receptor inactivation during the adolescent period: age-dependent changes in dorsal striatal D2(High) receptors.
Topics: Animals; Apomorphine; Autoradiography; Corpus Striatum; Domperidone; Dopamine Agonists; Dopamine Antagonists; Female; Male; Motor Activity; Quinolines; Rats; Receptors, Dopamine D2; Sex Characteristics; Tritium | 2014 |
Role of the D1 receptor for the dopamine agonist-induced one-trial behavioral sensitization of preweanling rats.
Topics: Aging; Animals; Apomorphine; Behavior, Animal; Benzazepines; Central Nervous System Stimulants; Cocaine; Dopamine Agonists; Female; Learning; Male; Methamphetamine; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1 | 2014 |
Affinity States of Striatal Dopamine D2 Receptors in Antipsychotic-Free Patients with Schizophrenia.
Topics: Adult; Antipsychotic Agents; Apomorphine; Brain Mapping; Corpus Striatum; Female; Humans; Male; Positron-Emission Tomography; Raclopride; Radioligand Assay; Radiopharmaceuticals; Receptors, Dopamine D2; Schizophrenia; Statistics as Topic; Young Adult | 2017 |
Amphetamine-Induced Striatal Dopamine Release Measured With an Agonist Radiotracer in Schizophrenia.
Topics: Adolescent; Adult; Amphetamine; Apomorphine; Corpus Striatum; Dopamine; Dopamine Agonists; Dopamine Uptake Inhibitors; Female; Humans; Male; Positron-Emission Tomography; Radioactive Tracers; Schizophrenia; Young Adult | 2018 |
Aporphines, 21. (1,2) Dopaminergic activity of aporphine and benzylisoquinoline derivatives. Synthesis of 8-hydroxyaporphines and 1-(hydroxybenzyl)-2-n-propyl-1,2,3,4-tetrahydroisoquinolines.
Topics: Animals; Aporphines; Behavior, Animal; Caudate Nucleus; Dopamine Antagonists; Humans; Injections; Isoquinolines; Male; Motor Activity; Olfactory Bulb; Putamen; Rats; Receptors, Dopamine; Rotation; Stereotyped Behavior; Structure-Activity Relationship; Time Factors | 1977 |
Aporphines. 14 Dopaminergic and antinociceptive activity of aporphine derivatives. Synthesis of 10-hydroxyaporphines and 10-hydroxy-N-n-propylnoraporphine.
Topics: Analgesics; Animals; Aporphines; Dopamine; Humans; Male; Mice; Neural Pathways; Rats; Reaction Time; Stereotyped Behavior; Structure-Activity Relationship | 1976 |
Synthesis and dopamine receptor affinities of enantiomers of 2-substituted apomorphines and their N-n-propyl analogues.
Topics: Animals; Apomorphine; Cattle; Dopamine Agents; Isomerism; Rats; Receptors, Dopamine | 1990 |
Synthesis and dopamine receptor affinity of (R)-(-)-2-fluoro-N-n-propylnorapomorphine: a highly potent and selective dopamine D2 agonist.
Topics: Animals; Apomorphine; Cell Membrane; Corpus Striatum; Molecular Structure; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Structure-Activity Relationship | 1990 |
Preparation of 7-oxaaporphine derivatives and evaluation of their dopaminergic activity.
Topics: Animals; Aporphines; Behavior, Animal; Chemical Phenomena; Chemistry; Hydrogen-Ion Concentration; Male; Mice; Mice, Inbred ICR; Motor Activity; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Spectrophotometry, Infrared; Structure-Activity Relationship | 1988 |
Aporphines. 34. (-)-2,10,11-Trihydroxy-N-n-propylnoraporphine, a novel dopaminergic aporphine alkaloid with anticonvulsant activity.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Aporphines; Chemical Phenomena; Chemistry; In Vitro Techniques; Mice; Papio; Photic Stimulation; Seizures | 1981 |
Aporphines, 36. Dopamine receptor interactions of trihydroxyaporphines. Synthesis, radioreceptor binding, and striatal adenylate cyclase stimulation of 2,10,11-trihydroxyaporphines in comparison with other hydroxylated aporphines.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Aporphines; Binding, Competitive; Cattle; Caudate Nucleus; Chemical Phenomena; Chemistry; Corpus Striatum; In Vitro Techniques; Radioligand Assay; Rats; Receptors, Dopamine; Spiperone | 1981 |
A functional test identifies dopamine agonists selective for D3 versus D2 receptors.
Topics: Animals; CHO Cells; Cricetinae; Dopamine Agents; Humans; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3 | 1995 |
Expression and pharmacological characterization of the human D3 dopamine receptor.
Topics: Animals; Binding, Competitive; Cells, Cultured; CHO Cells; Cricetinae; Dopamine; Dopamine Antagonists; GTP-Binding Proteins; Guanine Nucleotides; Humans; Potassium Channels; Rats; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Recombinant Proteins; Second Messenger Systems; Sulpiride | 1994 |
Comparative molecular field analysis-based prediction of drug affinities at recombinant D1A dopamine receptors.
Topics: Animals; Cell Line; Chlorocebus aethiops; Computer Graphics; Dopamine; Dopamine Agonists; Glioma; Humans; Kinetics; Models, Molecular; Receptors, Dopamine D1; Recombinant Proteins; Structure-Activity Relationship; Tumor Cells, Cultured | 1996 |
CoMFA-based prediction of agonist affinities at recombinant wild type versus serine to alanine point mutated D2 dopamine receptors.
Topics: Alanine; Amino Acid Substitution; Animals; Bromocriptine; Combinatorial Chemistry Techniques; Dopamine Agonists; Models, Molecular; Pergolide; Point Mutation; Radioligand Assay; Rats; Receptors, Dopamine D2; Recombinant Proteins; Serine; Structure-Activity Relationship; Tumor Cells, Cultured | 2000 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Synthesis and dopamine receptor affinities of N-alkyl-11-hydroxy-2-methoxynoraporphines: N-alkyl substituents determine D1 versus D2 receptor selectivity.
Topics: Animals; Aporphines; Binding, Competitive; Corpus Striatum; In Vitro Techniques; Radioligand Assay; Rats; Receptors, Dopamine D1; Receptors, Dopamine D2; Stereoisomerism; Structure-Activity Relationship | 2008 |
Synthesis and Evaluation of Fluorinated Aporphines: Potential Positron Emission Tomography Ligands for D2 Receptors
Topics: | 2011 |
Structure-Functional-Selectivity Relationship Studies of Novel Apomorphine Analogs to Develop D1R/D2R Biased Ligands.
Topics: | 2020 |