apomorphine has been researched along with clozapine in 152 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 65 (42.76) | 18.7374 |
| 1990's | 42 (27.63) | 18.2507 |
| 2000's | 28 (18.42) | 29.6817 |
| 2010's | 16 (10.53) | 24.3611 |
| 2020's | 1 (0.66) | 2.80 |
| Authors | Studies |
|---|---|
| Andrieux, M; Besançon, R; Giros, B; Martres, MP; Pilon, C; Schwartz, JC; Sokoloff, P | 1 |
| George, SR; Guan, HC; Laurier, LG; Ng, G; Niznik, HB; O'Dowd, BF; Seeman, P; Sunahara, RK; Torchia, J; Van Tol, HH | 1 |
| Bouthenet, ML; Giros, B; Martres, MP; Schwartz, JC; Sokoloff, P | 1 |
| Butler, DE; Coughenour, LL; DeWald, HA; Downs, DA; Heffner, TG; Lustgarten, D; Pugsley, TA; Wise, LD | 1 |
| Andrews, PR; Craik, DJ; Martin, JL | 1 |
| Brougham, LR; Ellefson, CR; Miller, A; Prodan, KA | 1 |
| Emms, F; Freedman, SB; Knowles, MR; Marwood, R; McAllister, G; Patel, S; Seabrook, GR | 1 |
| Bhatia, P; Brioni, JD; Chang, R; Donnelly-Roberts, DL; El Kouhen, O; Hakeem, AA; Henry, R; Hollingsworth, PR; Hsieh, GC; Kolasa, T; Marsh, KC; Martino, B; Matulenko, MA; Miller, LN; Moreland, RB; Mortell, K; Nakane, M; Namovic, MT; Patel, MV; Stewart, AO; Terranova, MA; Uchic, ME; Wetter, JM | 1 |
| Brioni, JD; Chang, R; Cowart, MD; Darbyshire, JF; Donnelly-Roberts, DL; El-Kouhen, OF; Gintant, G; Hakeem, AA; Hollingsworth, PR; Hsieh, GC; Kolasa, T; Marsh, KC; Martin, R; Martino, BR; Matulenko, MA; Miller, LN; Moreland, RB; Mortell, K; Nakane, M; Namovic, MT; Nelson, SL; Patel, MV; Rohde, JJ; Stewart, AO; Sullivan, JP; Terranova, MA; Uchic, ME; Wetter, JM | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Andres-Mach, M; Czuczwar, S; Dawidowski, M; Herold, F; Kleps, J; Mazurek, A; Mazurek, AP; Nowak, G; Pluciński, F; Stachowicz, K; Stefanowicz, J; Szewczyk, B; Sławińska, A; Słowiński, T; Wolska, I; Łuszczki, JJ | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bienkowski, P; Bucki, A; Jastrzębska-Więsek, M; Kazek, G; Kołaczkowski, M; Marcinkowska, M; Mierzejewski, P; Partyka, A; Pawłowski, M; Siwek, A; Śniecikowska, J; Wasik, A; Wesołowska, A | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Bączek, T; Belka, M; Bojarski, A; Herold, F; Kleps, J; Kozioł, AE; Król, M; Nowak, G; Siwek, A; Ślifirski, G; Stachowicz, K; Szewczyk, B; Turło, J; Ulenberg, S | 1 |
| Bączek, T; Belka, M; Bojarski, A; Herold, F; Kleps, J; Kozioł, AE; Król, M; Nowak, G; Podsadni, P; Siwek, A; Ślifirski, G; Stachowicz, K; Szewczyk, B; Turło, J | 1 |
| Alberts, I; Harding, WW; Juarez, R; Karki, A; Namballa, HK | 1 |
| Grol, CJ; Rollema, H; Westerink, BH | 1 |
| Carroll, BJ; Curtis, GC; Kokmen, E | 1 |
| Ljungberg, T; Ungerstedt, U | 2 |
| Costa, E; Gnegy, M; Uzunov, P | 1 |
| Clement-Cormier, YC; Robison, GA | 1 |
| Billingsley, ML; Goldstein, JM; Kubena, RK; Malick, JB | 1 |
| Engel, J; Goldstein, M; Nakamura, S | 1 |
| Cain, JC; Dren, AT; Grant, DS; Minard, FN | 1 |
| Lassen, JB | 1 |
| Marsden, CD; Pycock, CJ; Tarsy, D | 1 |
| Clement-Cormier, YC; Greengard, P; Kebabian, JW; Petzold, GL | 1 |
| Cervantes, P; Guyda, H; Lal, S; Nair, NP; Yassa, R | 1 |
| Horsman, L; Large, BT; Pullar, IA; Tye, NC; Wright, FC | 1 |
| Ljungberg, T | 1 |
| Di Chiara, G; Gessa, GL; Morelli, M; Porceddu, ML | 1 |
| Ahn, HS; Demirjian, C; Makman, MH; Mishra, RK | 1 |
| Gianutsos, G; Moore, KE | 2 |
| Bianchi, S; Consolo, S; Ghezzi, D; Ladinsky, H | 1 |
| Cheney, DL; Costa, E; Racagni, G; Trabucchi, M | 1 |
| Korf, J; Westerink, BH | 1 |
| Roufogalis, BD; Thornton, M; Wade, DN | 1 |
| Davis, JM; Smith, RC | 1 |
| Bürki, HR; Sayers, AC | 1 |
| Kelly, PH; Miller, RJ | 1 |
| Asper, H; Bürki, HR; Ruch, W; Sayers, AC | 1 |
| Costall, B; Naylor, RJ | 1 |
| Marsden, CD; Pycock, C; Tarsy, D | 1 |
| Skarsfeldt, T | 1 |
| Chai, B; Meltzer, HY | 1 |
| Chen, JP; Gardner, EL; Paredes, W; Ruan, D | 1 |
| Baldessarini, RJ; Campbell, A; Neumeyer, JL; Yeghiayan, S | 1 |
| Ichikawa, J; Meltzer, HY | 1 |
| Braff, DL; Geyer, MA; Keith, VA; Swerdlow, NR | 1 |
| Fink, H; Morgenstern, R; Ott, T; Schremmer, C | 1 |
| Chen, JP; Gardner, EL; Paredes, W | 1 |
| Murray, AM; Waddington, JL | 1 |
| Amdur, RL; Carvey, PM; Kao, LC; Klawans, HL; Lin, DH; Nath, ST; Singh, R; Zhang, TJ | 1 |
| Berghoff, W; Coughenour, LL; Courtland, GG; Myers, SL; Pugsley, TA; Shih, YH; Stewart, SF | 1 |
| Blaha, CD; Lane, RF; Rivet, JM | 1 |
| Johnson, KM; Snell, LD | 1 |
| Ekker, M; Sourkes, TL | 1 |
| Chang, KJ; Ferris, RM; Russell, A; Tang, FL | 1 |
| Salama, AI; Saller, CF | 1 |
| Chipkin, RE; Latranyi, MB | 1 |
| Wachtel, SR; White, FJ | 1 |
| Jenner, P; Marsden, CD; Rupniak, NM | 1 |
| Lindgren, S | 1 |
| Maidment, NT; Marsden, CA | 1 |
| Hoffmann, WE; Piercey, MF; Travis, M; Vogelsang, GD | 1 |
| Barrett, JE; Mansbach, RS | 1 |
| Fleminger, S; Hall, MD; Jenner, P; Kilpatrick, G; Mann, S; Marsden, CD; Rupniak, NM | 1 |
| Fuxe, K; Nyström, M; Ogren, SO; Smith, R; Tovi, M | 1 |
| Buylaert, WA; Green, AR; Heal, DJ | 1 |
| Biazzi, A; Fregnan, GB | 1 |
| Barghon, R; Colboc, O; Costentin, J; Protais, P | 1 |
| Consolo, S; Fusi, R; Garattini, S; Kolasa, K; Ladinsky, H | 1 |
| Colboc, O; Costentin, J; Dubuc, I; Protais, P | 1 |
| Eichenberger, E | 1 |
| Cagiano, R; Cattabeni, F; Coen, E; Cuomo, V; Mocchetti, I; Racagni, G | 1 |
| Cheal, M | 1 |
| Hall, MD; Jenner, P; Kilpatrick, G; Marsden, CD; Rupniak, NM | 1 |
| Fenton, HM; Gerhardt, S; Leszczak, E; Liebman, JM | 1 |
| Gold, R; Lemme, P; Mende, T; Morgenstern, R; Oelssner, W | 1 |
| Lee, EH; Rebec, GV | 1 |
| Fink, H; Morgenstern, R; Oelssner, W | 2 |
| Gardner, EL; Seeger, TF; Thal, L | 1 |
| Diamond, BI; Klawans, HL; Koller, WC; Nausieda, PA; Weiner, WJ | 1 |
| Angeby, T; Haglund, L; Köhler, C; Ogren, SO | 1 |
| Kim, HS; Liebman, J; Welch, JJ | 1 |
| Janssen, PF; Leysen, JE; Megens, AA; Schotte, A | 1 |
| Bourin, M; Bradwejn, J; Harro, J; Kõks, S; Lang, A; Männistö, PT; Oreland, L; Soosaar, A; Vasar, E; Volke, V | 1 |
| Amenta, F; Mammola, CL; Ricci, A; Vega, JA | 1 |
| Conway, PC; Corbett, R; Dunn, RW; Hartman, H; Helsley, GC; Kerman, LL; Strupczewski, JT; Woods, AT | 1 |
| Bruhwyler, J; Damas, J; Delarge, J; Geczy, J; Liégeois, JF; Masereel, B; Rogister, F | 1 |
| Cools, AR; de Beltrán, KK; Kobayashi, M; Koshikawa, N; Miwa, Y | 1 |
| Swerdlow, NR; Taaid, N; Zisook, D | 1 |
| Bowman, CE | 1 |
| Goldstein, JM; Litwin, LC; Malick, JB; Sutton, EB | 1 |
| Chakos, M; Cooper, T; Kane, J; Kronig, M; Lieberman, J; Munne, R; Pollack, S; Safferman, A; Szymanski, S; Umbricht, D | 1 |
| Lipska, BK; Weinberger, DR | 1 |
| Cooper, T; Howard, A; Kane, JM; Kronig, MH; Lieberman, JA; Masiar, SJ; Novacenko, H; Pollack, S; Safferman, AZ; Szymanski, S | 1 |
| Evans, DL; Figur, LM; Lahti, RA; Stratman, NC | 1 |
| Geyer, MA; Swerdlow, NR | 1 |
| Cohen, JM; Deutsch, SI; Hitri, A; Keuler, DJ; O'Connor, DA | 1 |
| Ewing, FE; Furman, JS; Howard, HR; Jackson, E; Johnson, C; Lowe, JA; Maloney, PR; Morrone, J; Newman, ME; Robinson, GL; Schmidt, AW; Seeger, TF; Seymour, PA; Zorn, SH | 1 |
| Minick, DJ; Norman, MH; Rigdon, GC | 1 |
| Havemann-Reinecke, U; Surmann, A | 1 |
| Cooper, BR; Cox, RF; Durcan, MJ; Gengo, PJ; Jones-Humble, SA; Lyerly, D; Morgan, PF; Norton, RM; Russell, AV; Tang, FL; Wang, CM; Watson, MJ | 1 |
| Atkinson, J; Heal, DJ; Needham, PL; Skill, MJ | 1 |
| Navas, F; Norman, MH; Rigdon, GC; Thompson, JB | 1 |
| Fici, GJ; Sethy, VH; VonVoigtlander, PF; Wu, H | 1 |
| Chaki, S; Kawashima, N; Kumagai, T; Nagamine, M; Nakazato, A; Ogawa, S; Okuyama, S; Suzuki, Y; Tomisawa, K; Yamaguchi, K | 1 |
| Baldessarini, RJ; Kula, NS; Neumeyer, JL; Tarazi, FI; Yeghiayan, SK | 1 |
| Geyer, MA; Swerdlow, NR; Varty, GB | 1 |
| Curzon, P; Decker, MW | 1 |
| Millan, MJ; Sebban, C; Spedding, M; Tesolin-Decros, B | 1 |
| Audinot, V; Brocco, M; Dekeyne, A; Despaux, N; Maiofiss, L; Millan, MJ; Newman-Tancredi, A; Peglion, JL; Queriaux, S; Rivet, JM | 1 |
| Boye, SM; Rompré, PP | 1 |
| Adachi, K; Cools, AR; Hasegawa, M; Hirose, N; Ikeda, H; Koshikawa, N; Sato, M | 1 |
| Barwick, VS; Hicks, PB; Jones, DH; Richter, JT; Young, KA | 1 |
| Gordon, M; Heinz-Esser, K; Kanwal, JS; Peng, JP | 1 |
| Boules, M; Cusack, B; Fauq, A; McCormick, DJ; Richelson, E; Tyler, BM | 1 |
| Alper, RH; Gilliland, SL | 1 |
| Armogida, M; Chiacchio, S; Colzi, A; Corsini, GU; DeMontis, MG; Maggio, R; Scarselli, M | 1 |
| Baldessarini, RJ; Bradley, MO; Campbell, A; Flood, JG; Hemamalini, S; Kula, NS; Shashoua, VE; Swindell, CS; Webb, NL | 1 |
| Fu, D; Javitch, JA; Lin, H; Strange, PG; Wilson, J | 1 |
| Ashby, CR; Blackburn, TP; Hashimoto, K; Middlemiss, DN; Minabe, Y; Shirayama, Y | 1 |
| Bucan, M; Fetsko, LA; Hranilovic, D; Wang, Y; Xu, R | 1 |
| Feldon, J; Higgins, GA; Leng, A; Ouagazzal, A | 1 |
| Ahnaou, A; Drinkenburg, WH; Megens, AA | 1 |
| Avanzi, V; Brandão, ML; Masson, S; Troncoso, AC | 1 |
| Durkin, S; Feldon, J; Russig, H; Spooren, W; Yee, BK | 1 |
| Araki, H; Choshi, T; Gomita, Y; Hibino, S; Shibata, K; Suemaru, K; Umeda, K; Yasuda, K | 1 |
| Katsuragi, T; Kita, S; Morishita, H; Sakata, N; Shibata, K | 1 |
| Aru, GN; Bortolato, M; Fà, M; Frau, R; Gessa, GL; Manunta, M; Mereu, G; Orrù, M; Puddu, M | 1 |
| Bitner, RS; Hollingsworth, PR; Hsieh, GC; Martino, B; Mikusa, JP; Moreland, RB | 1 |
| Archer, T; Eriksson, P; Fredriksson, A | 1 |
| Ablordeppey, SY; Altundas, R; Bricker, B; Jackson, T; Khan, A; Kumar, EV; Roth, BL; Zhu, XY | 1 |
| Comery, TA; Graf, R; Grauer, SM; Huselton, C; Liu, Z; Logue, SF; Marquis, KL; Navarra, R; Rosenzweig-Lipson, S; Stack, G; Sung, A | 1 |
| Goktalay, G; Kayir, H; Uzbay, T; Yildirim, M | 1 |
| Chen, Y; Liu, BF; Liu, X; Xu, X; Zhang, G | 1 |
| Du, RH; Fan, Y; Hu, G; Su, CJ; Xu, XQ | 1 |
| Hacksell, U; Hubbard, D; McFarland, K | 1 |
| Callahan, PM; Tehim, A; Terry, AV | 1 |
| Becker, A; Chindo, BA; Dehmel, P; Fendt, M; Kahl, E; Trzeczak, D | 1 |
| Aznar, S; Blázquez, G; Cañete, T; Corda, MG; Fernández-Teruel, A; Gerbolés, C; Giorgi, O; González-Maeso, J; Oliveras, I; Piludu, MA; Río-Alamos, C; Sampedro-Viana, D; Sánchez-González, A; Tobeña, A | 1 |
1 review(s) available for apomorphine and clozapine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
151 other study(ies) available for apomorphine and clozapine
| Article | Year |
|---|---|
Pharmacology of human dopamine D3 receptor expressed in a mammalian cell line: comparison with D2 receptor.
Topics: Animals; Chlorides; CHO Cells; Cricetinae; Dopamine; Dopamine Agents; Dopamine Antagonists; Guanylyl Imidodiphosphate; Humans; Lithium; Lithium Chloride; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Sodium Chloride; Sulpiride; Transfection | 1992 |
Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding, Competitive; Blotting, Northern; Brain; Cell Line; Cell Membrane; Cloning, Molecular; Dopamine; Humans; Kinetics; Molecular Sequence Data; Molecular Weight; Oligonucleotide Probes; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D5; RNA, Messenger; Sequence Homology, Nucleic Acid; Transfection | 1991 |
Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics.
Topics: Amino Acid Sequence; Animals; Antipsychotic Agents; Base Sequence; Brain Chemistry; Cell Line; Cloning, Molecular; Cricetinae; DNA; DNA Restriction Enzymes; Dopamine; Guanylyl Imidodiphosphate; Molecular Sequence Data; Nucleic Acid Hybridization; Polymerase Chain Reaction; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; RNA, Messenger; Sequence Homology, Nucleic Acid; Tissue Distribution | 1990 |
(5-Amino-1,3-dimethyl-1H-pyrazol-4-yl)(2-fluorophenyl)methanones . A series of novel potential antipsychotic agents.
Topics: Animals; Antipsychotic Agents; Apomorphine; Ataxia; Avoidance Learning; Brain; Cebus; Chemical Phenomena; Chemistry; Dopamine; Male; Mice; Motor Activity; Movement Disorders; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, Dopamine; Saimiri | 1986 |
Functional group contributions to drug-receptor interactions.
Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship | 1984 |
Synthesis of 8-aryltetrahydroisoquinolines as dopamine antagonists and evaluation for potential neuroleptic activity.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Binding, Competitive; Cattle; Central Nervous System; Dopamine; Dopamine Antagonists; Haloperidol; In Vitro Techniques; Isoquinolines; Male; Mice; Rats; Receptors, Dopamine | 1980 |
Expression and pharmacological characterization of the human D3 dopamine receptor.
Topics: Animals; Binding, Competitive; Cells, Cultured; CHO Cells; Cricetinae; Dopamine; Dopamine Antagonists; GTP-Binding Proteins; Guanine Nucleotides; Humans; Potassium Channels; Rats; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Recombinant Proteins; Second Messenger Systems; Sulpiride | 1994 |
1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction.
Topics: Animals; Benzamides; Binding Sites; Cell Line; Crystallography, X-Ray; Disease Models, Animal; Drug Evaluation, Preclinical; Erectile Dysfunction; Ferrets; Humans; Male; Models, Molecular; Molecular Structure; Oximes; Piperazines; Rats; Rats, Wistar; Receptors, Dopamine D4; Stereoisomerism; Structure-Activity Relationship | 2006 |
Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction.
Topics: Action Potentials; Administration, Oral; Animals; Benzamides; Biological Availability; Cell Line; Cyclic N-Oxides; Dogs; Erectile Dysfunction; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Haplorhini; Humans; In Vitro Techniques; Male; Patch-Clamp Techniques; Purkinje Fibers; Rats; Receptors, Dopamine D4; Structure-Activity Relationship | 2006 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Synthesis and biological investigation of potential atypical antipsychotics with a tropane core. Part 1.
Topics: Animals; Antipsychotic Agents; Dose-Response Relationship, Drug; Mice; Models, Molecular; Radioligand Assay; Rats; Receptors, Neurotransmitter; Structure-Activity Relationship; Tropanes | 2011 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Novel 5-HT6 receptor antagonists/D2 receptor partial agonists targeting behavioral and psychological symptoms of dementia.
Topics: Animals; Benzamides; Dementia; Dose-Response Relationship, Drug; Drug Partial Agonism; Humans; Indoles; Ligands; Male; Models, Molecular; Molecular Structure; Piperazines; Quinolones; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Serotonin; Structure-Activity Relationship; Swimming | 2015 |
Synthesis of novel pyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HT
Topics: Animals; Chemistry Techniques, Synthetic; Drug Design; Ligands; Mice; Pyrimidines; Receptor, Serotonin, 5-HT1A; Selective Serotonin Reuptake Inhibitors; Structure-Activity Relationship; Tryptamines | 2019 |
Synthesis of new 5,6,7,8-tetrahydropyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HT
Topics: Animals; Cells, Cultured; Crystallography, X-Ray; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Ligands; Male; Mice; Models, Molecular; Molecular Structure; Pyrimidines; Rats; Receptor, Serotonin, 5-HT1A; RNA-Binding Proteins; Structure-Activity Relationship; Tryptamines | 2019 |
Identification of C10 nitrogen-containing aporphines with dopamine D
Topics: Aporphines; Dopamine Agonists; Dose-Response Relationship, Drug; Humans; Ligands; Molecular Docking Simulation; Molecular Structure; Receptors, Dopamine D1; Receptors, Dopamine D5; Structure-Activity Relationship | 2020 |
Correlation between neuroleptic-induced suppression of stereotyped behaviour and HVA concentrations in rat brain.
Topics: Amphetamines; Animals; Antipsychotic Agents; Apomorphine; Behavior; Brain Chemistry; Clozapine; Depression, Chemical; Haloperidol; Homovanillic Acid; Humans; Male; Phenothiazines; Phenylacetates; Pimozide; Rats; Stereotyped Behavior; Tranquilizing Agents | 1976 |
Paradoxical response to dopamine agonists in tardive dyskinesia.
Topics: Adrenergic alpha-Agonists; Adult; Amantadine; Apomorphine; Benztropine; Clozapine; Deanol; Dextroamphetamine; Dose-Response Relationship, Drug; Drug Antagonism; Drug Tolerance; Dyskinesia, Drug-Induced; Female; Haloperidol; Humans; Levodopa; Physostigmine; Receptors, Dopamine; Reserpine; Stimulation, Chemical; Thioridazine | 1977 |
Behavioral patterns related to dopamine neurotransmission: effect of acute and chronic antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Brain; Clozapine; Dopamine; Electric Stimulation; Haloperidol; Motor Activity; Rats; Synaptic Transmission; Time Factors | 1977 |
Participation of an endogenous Ca++-blinding protein activator in the development of drug-induced supersensitivity of striatal dopamine receptors.
Topics: Adenylyl Cyclases; Animals; Antipsychotic Agents; Apomorphine; Calcium; Carrier Proteins; Clozapine; Corpus Striatum; Dibenzocycloheptenes; Dopamine; Haloperidol; Humans; Male; Rats; Receptors, Dopamine; Stereotyped Behavior | 1977 |
Adenylate cyclase from various dopaminergic areas of the brain and the action of antipsychotic drugs.
Topics: Adenylyl Cyclases; Amygdala; Animals; Antipsychotic Agents; Apomorphine; Brain; Caudate Nucleus; Clozapine; Dopamine; Fluphenazine; Isoproterenol; Loxapine; Median Eminence; Norepinephrine; Olfactory Bulb; Rats | 1977 |
Evaluation of naloxone in laboratory tests predictive of clinical antipsychotic activity.
Topics: Animals; Antipsychotic Agents; Apomorphine; Avoidance Learning; Clozapine; Conditioning, Operant; Dextroamphetamine; Dose-Response Relationship, Drug; Haloperidol; Humans; Male; Mice; Naloxone; Rats; Schizophrenia; Species Specificity; Stereotyped Behavior | 1977 |
Blockade of lergotrile or apomorphine induced turning behavior by haloperidol and clozapine.
Topics: Animals; Apomorphine; Behavior; Clozapine; Corpus Striatum; Dibenzazepines; Dominance, Cerebral; Dose-Response Relationship, Drug; Ergolines; Haloperidol; Humans; Hydroxydopamines; Male; Medial Forebrain Bundle; Premedication; Rats; Receptors, Dopamine; Stereotyped Behavior; Substantia Nigra | 1978 |
N-o-Methoxyphenylpiperazine: a simple blocker of dopaminergic receptors in the brain.
Topics: Animals; Apomorphine; Brain; Brain Chemistry; Clozapine; Dextroamphetamine; Diazepam; Homovanillic Acid; Hydroxydopamines; In Vitro Techniques; Male; Pargyline; Piperazines; Rats; Receptors, Dopamine; Time Factors | 1979 |
Inhibition of apomorphine-induced climbing in mice by cholinergic drugs and neuroleptics.
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Clozapine; Female; Haloperidol; Injections, Intramuscular; Mice; Oxotremorine; Parasympathomimetics; Physostigmine | 1979 |
Evidence that the different properties of haloperidol and clozapine are not explained by differences in anticholinergic potency.
Topics: Animals; Apomorphine; Behavior; Behavior, Animal; Clozapine; Dibenzazepines; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Haloperidol; Humans; Male; Motor Activity; Rats; Scopolamine; Stereotyped Behavior | 1979 |
Inhibition of turning behaviour by clozapine in mice with unilateral destruction of dopaminergic nerve terminals.
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Brain Chemistry; Clozapine; Corpus Striatum; Dibenzazepines; Dopamine; Dose-Response Relationship, Drug; Hydroxydopamines; Male; Mice; Models, Biological; Motor Activity; Time Factors | 1975 |
Chemistry of dopamine receptors.
Topics: Adenylyl Cyclases; Animals; Antipsychotic Agents; Apomorphine; Butyrophenones; Caudate Nucleus; Chemical Phenomena; Chemistry; Clozapine; Dopamine; Isoproterenol; Olfactory Bulb; Phenothiazines; Phenylephrine; Rats; Receptors, Drug | 1975 |
Effect of clozapine on apomorphine-induced growth hormone secretion and serum prolactin concentrations in schizophrenia.
Topics: Adult; Apomorphine; Clozapine; Dibenzazepines; Growth Hormone; Humans; Hypothalamo-Hypophyseal System; Male; Middle Aged; Prolactin; Receptors, Dopamine; Schizophrenia | 1979 |
Two dopamine receptors: supportive evidence with the rat rotational model.
Topics: Animals; Apomorphine; Behavior; Clozapine; Corpus Striatum; Dopamine; Ergolines; Haloperidol; Humans; Limbic System; Male; Rats; Receptors, Dopamine; Stereotyped Behavior; Time Factors | 1977 |
Reliability of two activity boxes commonly used to assess drug induced behavioural changes.
Topics: Animals; Apomorphine; Clozapine; Dextroamphetamine; Drug Interactions; Evaluation Studies as Topic; Humans; Male; Motor Activity; Phenoxybenzamine; Psychopharmacology; Rats; Reserpine; Stereotyped Behavior | 1978 |
Self-inhibitory dopamine-receptors and central effects of apomorphine.
Topics: Animals; Apomorphine; Benperidol; Brain; Clozapine; Droperidol; Exploratory Behavior; Haloperidol; Humans; Mice; Motor Activity; Pimozide; Rats; Receptors, Dopamine; Sleep | 1978 |
Catecholamine-sensitive adenylate cyclase in frontal cortex of primate brain.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Calcium; Catecholamines; Cerebral Cortex; Clozapine; Dopamine; Drug Combinations; Fluphenazine; Frontal Lobe; Guanosine Triphosphate; Haloperidol; Haplorhini; Isoproterenol; Macaca mulatta; Norepinephrine; Phentolamine; Receptors, Adrenergic; Receptors, Dopamine; Sodium Fluoride; Time Factors | 1976 |
Dopaminergic supersensitivity in striatum and olfactory tubercle following chronic administration of haloperidol or clozapine.
Topics: Animals; Apomorphine; Clozapine; Corpus Striatum; Dibenzazepines; Dopamine; Haloperidol; Male; Methyltyrosines; Mice; Mice, Inbred ICR; Motor Activity; Olfactory Bulb; Receptors, Dopamine; Time Factors | 1977 |
Possible significance of clozapine-induced increase in brain dopamine.
Topics: Animals; Apomorphine; Brain Chemistry; Clozapine; Dibenzazepines; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Mice, Inbred ICR; Norepinephrine; Stimulation, Chemical; Time Factors | 1977 |
Apparent lack of a dopaminergic-cholinergic link in the rat nucleus accumbens septi-tuberculum olfactorium.
Topics: Acetylcholine; Animals; Apomorphine; Bromocriptine; Chlorpromazine; Clozapine; Dextroamphetamine; Haloperidol; Nucleus Accumbens; Olfactory Bulb; Pimozide; Piribedil; Rats; Receptors, Cholinergic; Receptors, Dopamine; Septal Nuclei | 1977 |
In vivo actions of clozapine and haloperidol on the turnover rate of acetylcholine in rat striatum.
Topics: Animals; Apomorphine; Benztropine; Clozapine; Corpus Striatum; Dibenzazepines; Dopamine; Drug Interactions; Humans; Kinetics; Male; Motor Activity; Oxotremorine; Rats; Receptors, Drug; Stereotyped Behavior; Trihexyphenidyl | 1976 |
Acidic dopamine metabolites in cortical areas of the rat brain: localization and effects of drug.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamine; Animals; Apomorphine; Cerebral Cortex; Clozapine; Corpus Striatum; Haloperidol; Homovanillic Acid; Male; Morphine; Olfactory Bulb; Oxotremorine; Phenylacetates; Probenecid; Rats; Sulpiride; Thioridazine | 1976 |
Specificity of the dopamine sensitive adenylate cyclase for antipsychotic antagonists.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Chlorpromazine; Clozapine; Corpus Striatum; Dopamine; Dopamine Antagonists; Enzyme Activation; Haloperidol; Male; Metoclopramide; Rats; Sulpiride | 1976 |
Behavioral evidence for supersensitivity after chronic administration of haloperidol, clozapine, and thioridazine.
Topics: Animals; Apomorphine; Behavior; Clozapine; Dibenzazepines; Dopamine; Haloperidol; Humans; Motor Activity; Rats; Receptors, Drug; Stereotyped Behavior; Thioridazine; Time Factors | 1976 |
[Effects of anticholinergics and clozapine on the activation of the striatal dopaminergic system in the rat by haloperidol. Pharmacological findings (author's transl)].
Topics: Animals; Apomorphine; Atropine; Clozapine; Corpus Striatum; Dibenzazepines; Dopamine; Drug Synergism; Haloperidol; Humans; Movement Disorders; Rats; Receptors, Drug; Stereotyped Behavior | 1976 |
The interaction of neuroleptic and muscarinic agents with central dopaminergic systems.
Topics: Adenylyl Cyclase Inhibitors; Animals; Apomorphine; Behavior, Animal; Chlorpromazine; Clopenthixol; Clozapine; Corpus Striatum; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Flupenthixol; Male; Methamphetamine; Models, Biological; Oxotremorine; Parasympathomimetics; Pimozide; Rats; Scopolamine; Substantia Nigra; Thioridazine; Tranquilizing Agents | 1975 |
Neuroleptic-induced hypersensitivity of striatal dopamine receptors in the rat as a model of tardive dyskinesias. Effects of clozapine, haloperidol, loxapine and chlorpromazine.
Topics: Animals; Apomorphine; Chlorpromazine; Clozapine; Corpus Striatum; Dibenzazepines; Dibenzoxazepines; Disease Models, Animal; Dopamine; Drug Tolerance; Female; Haloperidol; Homovanillic Acid; Humans; Loxapine; Male; Movement Disorders; Rats; Receptors, Drug; Stereotyped Behavior; Substance Withdrawal Syndrome | 1975 |
Detection of the nueroleptic properties of clozapine, sulpiride and thioridazine.
Topics: Animals; Apomorphine; Behavior, Animal; Catalepsy; Clozapine; Dextroamphetamine; Dibenzazepines; Dose-Response Relationship, Drug; Drug Synergism; Fluphenazine; Haloperidol; Humans; Isoquinolines; Male; Methyltyrosines; Pimozide; Rats; Spiro Compounds; Stereotyped Behavior; Succinimides; Sulpiride; Thioridazine; Tranquilizing Agents | 1975 |
Inhibition of circling behavior by neuroleptic drugs in mice with unilateral 6-hydroxydopamine lesions of the striatum.
Topics: Animals; Apomorphine; Basal Ganglia Diseases; Behavior; Biogenic Amines; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Chlorpromazine; Clozapine; Corpus Striatum; Dextroamphetamine; Diazepam; Dopamine; Haloperidol; Humans; Hydroxydopamines; Levodopa; Male; Metoclopramide; Mice; Motor Activity; Pentobarbital; Phenoxybenzamine; Pimozide; Promethazine; Stereotyped Behavior; Tranquilizing Agents | 1975 |
Electrophysiological profile of the new atypical neuroleptic, sertindole, on midbrain dopamine neurones in rats: acute and repeated treatment.
Topics: Animals; Antipsychotic Agents; Apomorphine; Clozapine; Dextroamphetamine; Dopamine; Drug Administration Schedule; Electrophysiology; Haloperidol; Imidazoles; Indoles; Male; Mesencephalon; Neurons; Rats; Rats, Inbred Strains; Substantia Nigra; Tegmentum Mesencephali | 1992 |
The effect of chronic clozapine on basal dopamine release and apomorphine-induced DA release in the striatum and nucleus accumbens as measured by in vivo brain microdialysis.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Clozapine; Corpus Striatum; Dialysis; Dopamine; Homovanillic Acid; Hydroxyindoleacetic Acid; Kinetics; Male; Nucleus Accumbens; Rats; Rats, Wistar; Reference Values; Time Factors | 1992 |
Effects of acute and chronic clozapine on dopaminergic function in medial prefrontal cortex of awake, freely moving rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Apomorphine; Clozapine; Dopamine; Drug Administration Schedule; Frontal Lobe; Homovanillic Acid; Injections, Intraperitoneal; Kinetics; Male; Rats; Rats, Inbred Strains; Time Factors; Wakefulness | 1992 |
Selective antidopaminergic effects of S(+)N-n-propylnoraporphines in limbic versus extrapyramidal sites in rat brain: comparisons with typical and atypical antipsychotic agents.
Topics: Animals; Antipsychotic Agents; Apomorphine; Clozapine; Dibenzothiazepines; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Haloperidol; Limbic System; Male; Motor Activity; Pyramidal Tracts; Quetiapine Fumarate; Rats; Rats, Inbred Strains | 1991 |
Differential effects of repeated treatment with haloperidol and clozapine on dopamine release and metabolism in the striatum and the nucleus accumbens.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Clozapine; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Extracellular Space; Haloperidol; Hydroxyindoleacetic Acid; Injections, Subcutaneous; Male; Nucleus Accumbens; Rats; Rats, Inbred Strains | 1991 |
Effects of spiperone, raclopride, SCH 23390 and clozapine on apomorphine inhibition of sensorimotor gating of the startle response in the rat.
Topics: Analysis of Variance; Animals; Apomorphine; Benzazepines; Clozapine; Male; Raclopride; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Reflex, Startle; Salicylamides; Schizophrenia; Spiperone | 1991 |
Atypical neuroleptics suppress dopaminergic behavioral supersensitivity.
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Clozapine; Cyproheptadine; Haloperidol; Male; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Ritanserin; Serotonin Antagonists; Sulpiride; Thioridazine | 1990 |
Chronic treatment with clozapine selectively decreases basal dopamine release in nucleus accumbens but not in caudate-putamen as measured by in vivo brain microdialysis: further evidence for depolarization block.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Caudate Nucleus; Clozapine; Dialysis; Dopamine; Electrophysiology; Homovanillic Acid; Male; Neuromuscular Depolarizing Agents; Nucleus Accumbens; Putamen; Rats; Rats, Inbred Strains | 1991 |
The interaction of clozapine with dopamine D1 versus dopamine D2 receptor-mediated function: behavioural indices.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Behavior, Animal; Benzazepines; Clozapine; Dopamine; Grooming; Male; Quinolines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone | 1990 |
Clozapine fails to prevent the development of haloperidol-induced behavioral hypersensitivity in a cotreatment paradigm.
Topics: Animals; Apomorphine; Behavior, Animal; Binding, Competitive; Brain Chemistry; Clozapine; Corpus Striatum; Dopamine; Drug Interactions; Haloperidol; Male; Rats; Rats, Inbred Strains; Spiperone; Stereotyped Behavior; Thioridazine | 1990 |
CI-943, a potential antipsychotic agent. II. Neurochemical effects.
Topics: Animals; Antipsychotic Agents; Apomorphine; Brain Chemistry; Clozapine; Dopamine; Haloperidol; Imidazoles; In Vitro Techniques; Male; Mice; Neurotransmitter Agents; Norepinephrine; Prolactin; Pyrimidines; Rats; Rats, Inbred Strains; Serotonin; Spiperone | 1989 |
Selective inhibition of mesolimbic dopamine release following chronic administration of clozapine: involvement of alpha 1-noradrenergic receptors demonstrated by in vivo voltammetry.
Topics: Animals; Apomorphine; Clozapine; Corpus Striatum; Dibenzazepines; Dopamine; Haloperidol; Limbic System; Male; Nucleus Accumbens; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Reference Values; Septal Nuclei | 1988 |
Antagonism of N-methyl-D-aspartate-induced transmitter release in the rat striatum by phencyclidine-like drugs and its relationship to turning behavior.
Topics: Acetylcholine; Amphetamine; Animals; Apomorphine; Aspartic Acid; Benzomorphans; Chlorpromazine; Clozapine; Corpus Striatum; Cyclazocine; Dioxolanes; Dopamine; Haloperidol; Ketamine; Male; Mathematics; Motor Activity; N-Methylaspartate; Phencyclidine; Posture; Rats; Rats, Inbred Strains; Substantia Nigra | 1985 |
Differential effects of thioridazine, clozapine and metoclopramide on the induction of adrenomedullary enzymes by apomorphine.
Topics: Adrenal Medulla; Animals; Apomorphine; Clozapine; Corpus Striatum; Dibenzazepines; Enzyme Induction; Male; Metoclopramide; Ornithine Decarboxylase; Rats; Rats, Inbred Strains; Substantia Nigra; Thioridazine; Tyrosine 3-Monooxygenase | 1985 |
Evidence that the potential antipsychotic agent rimcazole (BW 234U) is a specific, competitive antagonist of sigma sites in brain.
Topics: Animals; Antipsychotic Agents; Apomorphine; Binding, Competitive; Brain; Carbazoles; Clozapine; Guinea Pigs; Kinetics; Male; Methylphenidate; Mice; Phenazocine; Phencyclidine; Phenoxybenzamine; Propranolol; Receptors, Opioid; Receptors, sigma; Sulpiride | 1986 |
3-Methoxytyramine accumulation: effects of typical neuroleptics and various atypical compounds.
Topics: 4-Butyrolactone; Animals; Antipsychotic Agents; Apomorphine; Benzazepines; Buspirone; Carbazoles; Chlorpromazine; Clozapine; Corpus Striatum; Dopamine; Dopamine Antagonists; Fluphenazine; Haloperidol; Male; Molindone; Pargyline; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Regression Analysis | 1986 |
Similarity of clozapine and SCH 23390 in reserpinized rats suggests a common mechanism of action.
Topics: Animals; Antipsychotic Agents; Apomorphine; Benzazepines; Clozapine; Dibenzazepines; Injections, Intraventricular; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reserpine; Stereotyped Behavior | 1987 |
Electrophysiological effects of BMY 14802, a new potential antipsychotic drug, on midbrain dopamine neurons in the rat: acute and chronic studies.
Topics: Animals; Antipsychotic Agents; Apomorphine; Brain; Clozapine; Dopamine; Electrophysiology; Haloperidol; Male; Neurons; Pyrimidines; Rats; Rats, Inbred Strains | 1988 |
Differential alteration of striatal D-1 and D-2 receptors induced by the long-term administration of haloperidol, sulpiride or clozapine to rats.
Topics: Animals; Apomorphine; Clozapine; Corpus Striatum; Dibenzazepines; Dose-Response Relationship, Drug; Haloperidol; Humans; Kinetics; Long-Term Care; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone; Stereotyped Behavior; Sulpiride; Thioxanthenes | 1985 |
Lack of effects of apomorphine, haloperidol and clozapine on the synthesis and utilization of brain GABA.
Topics: Animals; Apomorphine; Brain; Clozapine; Corpus Striatum; Dibenzazepines; gamma-Aminobutyric Acid; Haloperidol; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Substantia Nigra | 1987 |
Repeated atypical neuroleptic administration: effects on central dopamine metabolism monitored by in vivo voltammetry.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Brain Chemistry; Clozapine; Corpus Striatum; Dibenzazepines; Electrochemistry; Male; Nucleus Accumbens; Phenylacetates; Rats; Rats, Inbred Strains; Thioridazine; Time Factors | 1987 |
Electrophysiological evaluation of a partial agonist of dopamine receptors.
Topics: Amphetamine; Animals; Apomorphine; Clozapine; Dose-Response Relationship, Drug; Electric Stimulation; Ergolines; Haloperidol; Lisuride; Male; Neurons; Rats; Rats, Inbred Strains; Receptors, Dopamine; Substantia Nigra | 1987 |
Discriminative stimulus properties of buspirone in the pigeon.
Topics: Animals; Apomorphine; Buspirone; Clozapine; Columbidae; Discrimination Learning; Haloperidol; Methysergide; Midazolam; Pyrimidines; Serotonin | 1987 |
Chronic treatment with clozapine, unlike haloperidol, does not induce changes in striatal D-2 receptor function in the rat.
Topics: Acetylcholine; Animals; Apomorphine; Body Weight; Clozapine; Corpus Striatum; Dibenzazepines; Haloperidol; Humans; Male; Mastication; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Thioxanthenes; Tritium | 1985 |
Central catecholamine neurons, behavior and neuroleptic drugs: an analysis to understand the involvement of catecholamines in schizophrenia.
Topics: Adrenal Cortex Hormones; Animals; Apomorphine; Avoidance Learning; Behavior, Animal; Brain; Catecholamines; Cerebral Cortex; Clozapine; Corpus Striatum; Dopamine; Dopamine beta-Hydroxylase; Enzyme Inhibitors; Humans; Limbic System; Motor Activity; Neurons; Norepinephrine; Rats; Receptors, Drug; Schizophrenia; Self Stimulation; Tranquilizing Agents; Tyrosine 3-Monooxygenase | 1974 |
Inhibition of apomorphine-, bromocriptine- and lergotrile-induced circling behaviour in rats by subsequent haloperidol administration.
Topics: Animals; Apomorphine; Behavior; Bromocriptine; Clozapine; Ergolines; Haloperidol; Humans; Male; Rats; Stereotyped Behavior; Time Factors | 1980 |
Behavioral, anti-dopaminergic, and prohypnotic effects of neuroleptics during and after prolonged treatment.
Topics: Amphetamine; Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Clozapine; Dopamine; Dopamine Antagonists; Drug Tolerance; Female; Haloperidol; Hypnotics and Sedatives; Male; Mice; Motor Activity; Oxazoles; Piperazines; Receptors, Dopamine; Time Factors | 1980 |
Hypokinesia in mice and catalepsy in rats elicited by morphine associated with antidopaminergic agents, including atypical neuroleptics.
Topics: alpha-Methyltyrosine; Animals; Antipsychotic Agents; Apomorphine; Catalepsy; Clozapine; Haloperidol; Humans; Male; Methyltyrosines; Mice; Morphine; Motor Activity; Piperazines; Pyrimidines; Rats; Rats, Inbred Strains; Thioridazine | 1981 |
Neurochemical effects of buspirone, a novel psychotropic drug, on the central cholinergic system.
Topics: Acetylcholine; Animals; Anti-Anxiety Agents; Apomorphine; Brain Chemistry; Buspirone; Clozapine; Corpus Striatum; Female; Haloperidol; Male; Parasympathetic Nervous System; Postural Balance; Pyrimidines; Rats; Time Factors | 1982 |
Antagonism of the apomorphine-induced yawning by "atypical" neuroleptics.
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Clozapine; Dopamine; Dose-Response Relationship, Drug; Male; Physostigmine; Rats; Rats, Inbred Strains; Sulpiride | 1982 |
Pharmacology of fluperlapine compared with clozapine.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Apomorphine; Binding, Competitive; Brain Chemistry; Clozapine; Dibenzazepines; Dopamine; Electroencephalography; Homovanillic Acid; Humans; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1984 |
Behavioural and biochemical effects in the adult rat after prolonged postnatal administration of clozapine.
Topics: Animals; Apomorphine; Behavior, Animal; Body Weight; Brain Chemistry; Clozapine; Corpus Striatum; Dibenzazepines; Dopamine; Homovanillic Acid; Humans; Male; Motor Activity; Rats; Rats, Inbred Strains; Reinforcement Schedule; Stereotyped Behavior | 1983 |
Differential effects of haloperidol and clozapine on attention.
Topics: Animals; Apomorphine; Attention; Clozapine; Dibenzazepines; Female; Gerbillinae; Haloperidol; Male; Norepinephrine; Time Factors | 1984 |
Differential alterations in striatal dopamine receptor sensitivity induced by repeated administration of clinically equivalent doses of haloperidol, sulpiride or clozapine in rats.
Topics: Animals; Apomorphine; Clozapine; Corpus Striatum; Dibenzazepines; Haloperidol; Humans; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Sulpiride | 1984 |
Evidence for heterogeneous rotational responsiveness to apomorphine, 3-PPP and SKF 38393 in 6-hydroxydopamine-denervated rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Benzazepines; Clozapine; Ergolines; Humans; Hydroxydopamines; Male; Oxidopamine; Pergolide; Piperidines; Postural Balance; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereotyped Behavior; Sympathectomy, Chemical | 1984 |
Drug-induced modulation of locomotor hyperactivity induced by picrotoxin in nucleus accumbens.
Topics: Animals; Apomorphine; Carbachol; Clozapine; Diazepam; Haloperidol; Lisuride; Lysergic Acid Diethylamide; Male; Motor Activity; Nucleus Accumbens; Picrotoxin; Rats; Rats, Inbred Strains; Reserpine; Septal Nuclei; Sulpiride | 1984 |
Tolerance to amphetamine-induced inhibition of neuronal activity in the central amygdaloid nucleus.
Topics: Amygdala; Animals; Apomorphine; Clozapine; Dextroamphetamine; Drug Tolerance; Male; Neurons; Rats; Rats, Inbred Strains | 1983 |
LSD-potentiated apomorphine hypermotility: a model for differentiating antipsychotic drugs.
Topics: Animals; Apomorphine; Chlorpromazine; Clozapine; Disease Models, Animal; Drug Antagonism; Haloperidol; Humans; Hyperkinesis; Lysergic Acid Diethylamide; Male; Motor Activity; Rats; Rats, Inbred Strains; Sulpiride | 1983 |
Clozapine--a serotonin antagonist?
Topics: Animals; Apomorphine; Clonidine; Clozapine; Dibenzazepines; Drug Interactions; Haloperidol; Lysergic Acid Diethylamide; Male; Microinjections; Motor Activity; Nucleus Accumbens; Phentolamine; Raphe Nuclei; Rats; Rats, Inbred Strains; Serotonin Antagonists | 1984 |
Behavioral and biochemical aspects of neuroleptic-induced dopaminergic supersensitivity: studies with chronic clozapine and haloperidol.
Topics: Acetylcholine; Animals; Apomorphine; Behavior, Animal; Clozapine; Corpus Striatum; Dibenzazepines; Haloperidol; Humans; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1982 |
The pharmacological evaluation of pergolide mesylate as a potential anti-parkinson agent.
Topics: alpha-Methyltyrosine; Animals; Antiparkinson Agents; Apomorphine; Clozapine; Drug Interactions; Emetics; Ergolines; Guinea Pigs; Haloperidol; Humans; Hydroxydopamines; Male; Methyltyrosines; Pergolide; Rats; Stereotyped Behavior | 1980 |
Regional blockade by neuroleptic drugs of in vivo 3H-spiperone binding in the rat brain. Relation to blockade of apomorphine induced hyperactivity and stereotypies.
Topics: Animals; Apomorphine; Binding, Competitive; Brain; Butyrophenones; Chlorpromazine; Clozapine; Haloperidol; Humans; Hyperkinesis; Kinetics; Organ Specificity; Rats; Receptors, Dopamine; Receptors, Drug; Spiperone; Stereotyped Behavior; Sulpiride; Thioridazine | 1981 |
Amphetamine-induced increases in dopaminergic single cell firing rate after haloperidol pretreatment. Correlation with extrapyramidal side effects.
Topics: Animals; Apomorphine; Brain; Clozapine; Dextroamphetamine; Dopamine; Drug Interactions; Extrapyramidal Tracts; Haloperidol; Male; Metoclopramide; Neurons; Rats; Substantia Nigra; Thioridazine | 1980 |
Occupancy of central neurotransmitter receptors by risperidone, clozapine and haloperidol, measured ex vivo by quantitative autoradiography.
Topics: Animals; Antipsychotic Agents; Apomorphine; Autoradiography; Behavior, Animal; Clozapine; Guinea Pigs; Haloperidol; In Vitro Techniques; Iodine Radioisotopes; Isoxazoles; Male; Mescaline; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Neurotransmitter; Receptors, Serotonin; Risperidone; Stereotyped Behavior | 1993 |
Role of N-methyl-D-aspartic acid and cholecystokinin receptors in apomorphine-induced aggressive behaviour in rats.
Topics: Aggression; Animals; Apomorphine; Benzodiazepinones; Brain Chemistry; Clozapine; Devazepide; Dizocilpine Maleate; Haloperidol; Male; Phenylurea Compounds; Radioligand Assay; Rats; Rats, Wistar; Receptors, Cholecystokinin; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate | 1995 |
Localisation of dopamine D3 receptor in the rat cerebellar cortex: a light microscope autoradiographic study.
Topics: Animals; Apomorphine; Autoradiography; Binding, Competitive; Cerebellar Cortex; Clozapine; Dopamine Agonists; Purkinje Cells; Radioligand Assay; Rats; Rats, Wistar; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Tetrahydronaphthalenes | 1995 |
Effects of atypical antipsychotic agents on social behavior in rodents.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Apomorphine; Benzazepines; Catalepsy; Chlorpromazine; Clozapine; Diazepam; Haloperidol; Isoxazoles; Male; Mice; Mice, Inbred Strains; Piperidines; Raclopride; Radioligand Assay; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Serotonin; Risperidone; Salicylamides; Social Behavior | 1993 |
Modulation of the clozapine structure increases its selectivity for the dopamine D4 receptor.
Topics: Apomorphine; Binding, Competitive; Cells, Cultured; Clozapine; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Humans; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D4; Spiperone; Structure-Activity Relationship | 1995 |
Clozapine injected into the nucleus accumbens potentiates apomorphine-induced jaw movements.
Topics: Analysis of Variance; Animals; Apomorphine; Carbachol; Clozapine; Drug Interactions; Injections, Intravenous; Jaw; Male; Muscarinic Antagonists; N-Methylscopolamine; Nucleus Accumbens; Parasympatholytics; Prazosin; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Scopolamine Derivatives; Serotonin Antagonists | 1994 |
Seroquel (ICI 204,636) restores prepulse inhibition of acoustic startle in apomorphine-treated rats: Similarities to clozapine.
Topics: Acoustic Stimulation; Animals; Antipsychotic Agents; Apomorphine; Clozapine; Dibenzothiazepines; Dose-Response Relationship, Drug; Male; Quetiapine Fumarate; Rats; Rats, Sprague-Dawley; Reflex, Startle | 1994 |
Drug-licensing anomalies and Parkinson's disease.
Topics: Apomorphine; Clozapine; Drug Approval; Humans; Parkinson Disease; United Kingdom | 1995 |
Seroquel: electrophysiological profile of a potential atypical antipsychotic.
Topics: Action Potentials; Amphetamine; Animals; Antipsychotic Agents; Apomorphine; Brain; Clozapine; Dibenzothiazepines; Dopamine; Dose-Response Relationship, Drug; Electrophysiology; Haloperidol; Male; Microelectrodes; Quetiapine Fumarate; Rats; Rats, Sprague-Dawley; Substantia Nigra | 1993 |
Clozapine effects on neuroendocrine response to apomorphine challenge testing in chronic neuroleptic nonresponsive schizophrenia: preliminary findings.
Topics: Adult; Analysis of Variance; Apomorphine; Clozapine; Growth Hormone; Humans; Male; Prolactin; Schizophrenia; Schizophrenic Psychology | 1995 |
Subchronic treatment with haloperidol and clozapine in rats with neonatal excitotoxic hippocampal damage.
Topics: Animals; Animals, Newborn; Apomorphine; Clozapine; Female; Haloperidol; Hippocampus; Ibotenic Acid; Motor Activity; Neurotoxins; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Stereotyped Behavior; Substance Withdrawal Syndrome | 1994 |
Predictors of response to clozapine.
Topics: Adult; Age Factors; Age of Onset; Antipsychotic Agents; Apomorphine; Basal Ganglia Diseases; Clozapine; Female; Growth Hormone; Humans; Male; Probability; Prolactin; Schizophrenia; Schizophrenic Psychology; Sex Factors; Treatment Outcome | 1994 |
Dopamine D4 versus D2 receptor selectivity of dopamine receptor antagonists: possible therapeutic implications.
Topics: Animals; Apomorphine; Butyrophenones; Cell Line; Chlorpromazine; Clozapine; Dopamine Agents; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Haloperidol; Raclopride; Radioligand Assay; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D4; Salicylamides; Trifluoperazine | 1993 |
Clozapine and haloperidol in an animal model of sensorimotor gating deficits in schizophrenia.
Topics: Animals; Apomorphine; Clozapine; Disease Models, Animal; Dose-Response Relationship, Drug; Habituation, Psychophysiologic; Haloperidol; Male; Rats; Rats, Sprague-Dawley; Reflex, Startle; Schizophrenic Psychology | 1993 |
Differentiation between MK-801- and apomorphine-induced stereotyped behaviors in mice.
Topics: Analysis of Variance; Animals; Apomorphine; Clozapine; Dizocilpine Maleate; Haloperidol; Male; Mice; Stereotyped Behavior; Time Factors | 1993 |
3-Benzisothiazolylpiperazine derivatives as potential atypical antipsychotic agents.
Topics: Amphetamine; Animals; Antipsychotic Agents; Apomorphine; Avoidance Learning; Brain; Catalepsy; Clozapine; Dopamine; Drug Design; Humans; Molecular Structure; Phosphatidylinositols; Piperazines; Prazosin; Rats; Receptors, Adrenergic; Receptors, Dopamine; Serotonin Antagonists; Thiazoles | 1996 |
Effect of linking bridge modifications on the antipsychotic profile of some phthalimide and isoindolinone derivatives.
Topics: Animals; Antipsychotic Agents; Apomorphine; Binding, Competitive; Brain; Clozapine; Haloperidol; Indoles; Ketanserin; Magnetic Resonance Spectroscopy; Male; Mice; Molecular Conformation; Phthalimides; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Serotonin; Serotonin; Serotonin Antagonists | 1996 |
Injection of apomorphine--a test to predict individual different dopaminergic sensitivity?
Topics: Adrenocorticotropic Hormone; Animals; Antipsychotic Agents; Apomorphine; Clozapine; Corticosterone; Dopamine Agonists; Drug Interactions; Haloperidol; Injections; Male; Motor Activity; Rats; Rats, Wistar; Stereotyped Behavior | 1995 |
Preclinical neurochemical and electrophysiological profile of 1192U90, a potential antipsychotic.
Topics: Amphetamine; Animals; Antipsychotic Agents; Apomorphine; Biogenic Amines; Brain; Clozapine; Male; Neurons; Piperazines; Radioligand Assay; Rats; Thiazoles | 1996 |
Zotepine: preclinical tests predict antipsychotic efficacy and an atypical profile.
Topics: Animals; Antipsychotic Agents; Apomorphine; Binding, Competitive; Clozapine; Dibenzothiepins; Dose-Response Relationship, Drug; Humans; Mice; Mice, Inbred Strains; Receptors, Dopamine; Time Factors | 1996 |
Synthesis and evaluation of heterocyclic carboxamides as potential antipsychotic agents.
Topics: Animals; Antipsychotic Agents; Apomorphine; Benzamides; Clozapine; Heterocyclic Compounds; Magnetic Resonance Spectroscopy; Mice; Molecular Structure; Piperazines; Raclopride; Receptors, Dopamine; Receptors, Serotonin; Risperidone; Salicylamides; Thiazoles | 1996 |
D1 dopamine receptor activity of anti-parkinsonian drugs.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antiparkinson Agents; Apomorphine; Benzazepines; Benzothiazoles; Bromocriptine; Cells, Cultured; Cerebellum; Clozapine; Cyclic AMP; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Pergolide; Pramipexole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Tetrahydronaphthalenes; Thiazoles | 1997 |
The atypical antipsychotic profile of NRA0045, a novel dopamine D4 and 5-hydroxytryptamine2A receptor antagonist, in rats.
Topics: Animals; Antipsychotic Agents; Apomorphine; Clozapine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Male; Maze Learning; Methamphetamine; Motor Activity; Pyrrolidines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D4; Receptors, Serotonin; Serotonin Antagonists; Thiazoles | 1997 |
Long-term effects of S(+)N-n-propylnorapomorphine compared with typical and atypical antipsychotics: differential increases of cerebrocortical D2-like and striatolimbic D4-like dopamine receptors.
Topics: Animals; Antipsychotic Agents; Apomorphine; Autoradiography; Cell Line; Cerebral Cortex; Clozapine; Dopamine Agonists; Drug Design; Fluphenazine; Limbic System; Male; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D4 | 1997 |
Discrepant findings of clozapine effects on prepulse inhibition of startle: is it the route or the rat?
Topics: Animals; Antipsychotic Agents; Apomorphine; Clozapine; Dopamine Agonists; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reflex, Startle; Species Specificity | 1998 |
Effects of phencyclidine (PCP) and (+)MK-801 on sensorimotor gating in CD-1 mice.
Topics: Acoustic Stimulation; Animals; Apomorphine; Clozapine; Dextroamphetamine; Dizocilpine Maleate; Dopamine Agonists; Dose-Response Relationship, Drug; Haloperidol; Male; Mice; Mice, Inbred Strains; Phencyclidine; Piperidines; Rats; Receptors, sigma; Reflex, Startle; Species Specificity | 1998 |
Contrasting EEG profiles elicited by antipsychotic agents in the prefrontal cortex of the conscious rat: antagonism of the effects of clozapine by modafinil.
Topics: Animals; Antipsychotic Agents; Apomorphine; Benzhydryl Compounds; Central Nervous System Stimulants; Clozapine; Dopamine Agonists; Electroencephalography; Injections, Subcutaneous; Male; Modafinil; Motor Cortex; Prefrontal Cortex; Rats; Rats, Wistar; Somatosensory Cortex | 1999 |
S18327 (1-[2-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)piperid-1-yl]ethyl]3-phenyl imidazolin-2-one), a novel, potential antipsychotic displaying marked antagonist properties at alpha(1)- and alpha(2)-adrenergic receptors: II. Functional profile and a multipara
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic Antagonists; Aggression; Amphetamine; Animals; Antipsychotic Agents; Apomorphine; Avoidance Learning; Clozapine; Cocaine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Extrapyramidal Tracts; Haloperidol; Imidazoles; Isoxazoles; Male; Mice; Pain Measurement; Protein Binding; Rats; Rats, Wistar; Receptors, Histamine; Receptors, Muscarinic | 2000 |
Behavioral evidence of depolarization block of dopamine neurons after chronic treatment with haloperidol and clozapine.
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Brain; Clozapine; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Electric Stimulation; Electrophysiology; Haloperidol; Male; Neurons; Rats; Rats, Long-Evans; Reward; Sensory Thresholds; Time Factors | 2000 |
Effects of chronic haloperidol and clozapine on vacuous chewing and dopamine-mediated jaw movements in rats: evaluation of a revised animal model of tardive dyskinesia.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Behavior, Animal; Clozapine; Disease Models, Animal; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dyskinesia, Drug-Induced; Haloperidol; Jaw; Male; Mastication; Quinpirole; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Serotonin Antagonists | 1999 |
Subthalamic nucleus microinjections of 5-HT2 receptor antagonists suppress stereotypy in rats.
Topics: Animals; Apomorphine; Behavior, Animal; Clozapine; Ergolines; Fluorobenzenes; Male; Mastication; Microinjections; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Antagonists; Stereotypic Movement Disorder; Subthalamic Nucleus | 2000 |
Auditory responses from the frontal cortex in the mustached bat, Pteronotus parnellii.
Topics: Animals; Apomorphine; Behavior, Animal; Clozapine; Ergolines; Fluorobenzenes; Male; Mastication; Microinjections; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Antagonists; Stereotypic Movement Disorder; Subthalamic Nucleus | 2000 |
Effects of a novel neurotensin peptide analog given extracranially on CNS behaviors mediated by apomorphine and haloperidol.
Topics: Animals; Apomorphine; Behavior, Animal; Body Temperature; Catalepsy; Clozapine; Haloperidol; Injections, Intraperitoneal; Male; Mice; Motor Activity; Neurotensin; Peptide Fragments; Rats; Rats, Sprague-Dawley; Time Factors | 2000 |
Characterization of dopaminergic compounds at hD2short, hD4.2 and hD4.7 receptors in agonist-stimulated [35S]GTPgammaS binding assays.
Topics: Animals; Apomorphine; Benzodiazepines; Binding, Competitive; CHO Cells; Clozapine; Cricetinae; Dopamine Agonists; Dopamine Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Olanzapine; Pirenzepine; Radioligand Assay; Receptors, Dopamine; Selective Serotonin Reuptake Inhibitors; Sulfur Radioisotopes; Transfection | 2000 |
Reconstitution of functional dopamine D(2s) receptor by co-expression of amino- and carboxyl-terminal receptor fragments.
Topics: Animals; Apomorphine; Binding, Competitive; Clozapine; Colforsin; COS Cells; Cyclic AMP; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Gene Expression; Haloperidol; Membranes; Peptide Fragments; Pergolide; Quinpirole; Radioligand Assay; Rats; Receptors, Dopamine D2; Recombinant Fusion Proteins; Spiperone; Transfection; Tritium | 2000 |
Fatty acid derivatives of clozapine: prolonged antidopaminergic activity of docosahexaenoylclozapine in the rat.
Topics: Amides; Animals; Apomorphine; Arousal; Brain; Catalepsy; Clozapine; Docosahexaenoic Acids; Dose-Response Relationship, Drug; Drug Interactions; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, Dopamine | 2001 |
Mechanisms of inverse agonism of antipsychotic drugs at the D(2) dopamine receptor: use of a mutant D(2) dopamine receptor that adopts the activated conformation.
Topics: 1-Methyl-3-isobutylxanthine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Apomorphine; Binding, Competitive; Bromocriptine; Butaclamol; Chlorpromazine; CHO Cells; Clozapine; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; GTP-Binding Proteins; Haloperidol; Humans; Macromolecular Substances; Mutagenesis, Site-Directed; Phenethylamines; Piperidines; Protein Binding; Protein Conformation; Radioligand Assay; Receptors, Dopamine D2; Recombinant Fusion Proteins; Sodium; Spiperone; Structure-Activity Relationship; Sulpiride; Transfection; Tyramine | 2001 |
Effect of acute and chronic administration of the selective 5-HT2C receptor antagonist SB-243213 on midbrain dopamine neurons in the rat: an in vivo extracellular single cell study.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Action Potentials; Analysis of Variance; Animals; Apomorphine; beta-Cyclodextrins; Cell Count; Clozapine; Cyclodextrins; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Haloperidol; Indoles; Male; Neurons; Pyridines; Rats; Rats, Sprague-Dawley; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Substantia Nigra; Ventral Tegmental Area | 2002 |
Dopamine D2S and D2L receptors may differentially contribute to the actions of antipsychotic and psychotic agents in mice.
Topics: Amphetamine; Animals; Antipsychotic Agents; Apomorphine; Clozapine; Dopamine Agonists; Dose-Response Relationship, Drug; Hallucinogens; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Parkinsonian Disorders; Protein Isoforms; Raclopride; Receptors, Dopamine D2 | 2002 |
Effect of the 5-HT6 receptor antagonists Ro04-6790 and Ro65-7199 on latent inhibition and prepulse inhibition in the rat: comparison to clozapine.
Topics: Acetylcholine; Animals; Antipsychotic Agents; Apomorphine; Avoidance Learning; Cerebral Cortex; Clozapine; Dopamine Antagonists; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Hippocampus; Lysergic Acid Diethylamide; Male; Maze Learning; Memory; Phencyclidine; Pyrimidines; Rats; Rats, Wistar; Receptors, Serotonin; Reflex, Startle; Serotonin Antagonists | 2003 |
The atypical antipsychotics risperidone, clozapine and olanzapine differ regarding their sedative potency in rats.
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Benzodiazepines; Clozapine; Conscious Sedation; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Combinations; Electroencephalography; Fourier Analysis; Hypnotics and Sedatives; Male; Olanzapine; Pirenzepine; Rats; Rats, Wistar; Risperidone; Stereotyped Behavior; Time Factors | 2003 |
Effects of apomorphine and clozapine on conditioned freezing and latent inhibition.
Topics: Animals; Apomorphine; Clozapine; Conditioning, Psychological; Electric Stimulation; Immobilization; Inferior Colliculi; Inhibition, Psychological; Male; Rats; Rats, Wistar | 2003 |
Apomorphine-induced disruption of prepulse inhibition that can be normalised by systemic haloperidol is insensitive to clozapine pretreatment.
Topics: Animals; Antiparkinson Agents; Antipsychotic Agents; Apomorphine; Clozapine; Drug Interactions; Haloperidol; Male; Mice; Mice, Inbred C57BL; Reflex, Startle | 2004 |
Nicotine blocks apomorphine-induced disruption of prepulse inhibition of the acoustic startle in rats: possible involvement of central nicotinic alpha7 receptors.
Topics: Acoustic Stimulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Apomorphine; Central Nervous System; Clozapine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Haloperidol; Male; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phencyclidine; Rats; Rats, Wistar; Receptors, Nicotinic; Reflex, Startle | 2004 |
A new approach to finding specific dopamine D4 receptor agonists.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Amino Acid Sequence; Animals; Apomorphine; Blotting, Western; Bromocriptine; Cloning, Molecular; Clozapine; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Synergism; Guinea Pigs; In Vitro Techniques; Male; Molecular Sequence Data; Muscle Contraction; Phenethylamines; Prazosin; Quinpirole; Receptors, Dopamine D2; Receptors, Dopamine D4; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Alignment; Sequence Homology, Amino Acid; Vas Deferens | 2005 |
Kappa opioid receptor activation disrupts prepulse inhibition of the acoustic startle in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acoustic Stimulation; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Antipsychotic Agents; Apomorphine; Clozapine; Dizocilpine Maleate; Dopamine Agonists; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Excitatory Amino Acid Antagonists; Haloperidol; Inhibition, Psychological; Male; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid, kappa; Reflex, Startle | 2005 |
Central oxytocinergic and dopaminergic mechanisms regulating penile erection in conscious rats.
Topics: Animals; Apomorphine; Clozapine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Models, Biological; Oxytocin; Penile Erection; Rats; Rats, Wistar; Vasotocin | 2005 |
Postnatal iron-induced motor behaviour alterations following chronic neuroleptic administration in mice.
Topics: Animals; Antipsychotic Agents; Apomorphine; Basal Ganglia; Clozapine; Dopamine Agonists; Drug Interactions; Female; Haloperidol; Hyperkinesis; Iron; Male; Mice; Mice, Inbred C57BL; Motor Activity; Pregnancy | 2006 |
Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one.
Topics: Animals; Antipsychotic Agents; Apomorphine; Azepines; Butyrophenones; Clozapine; Haloperidol; Lethal Dose 50; Male; Mice; Molecular Structure; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Structure-Activity Relationship | 2008 |
WAY-163909, a 5-HT2C agonist, enhances the preclinical potency of current antipsychotics.
Topics: Animals; Antipsychotic Agents; Apomorphine; Avoidance Learning; Azepines; Catalepsy; Clozapine; Dizocilpine Maleate; Drug Synergism; Drug Therapy, Combination; Haloperidol; Indoles; Male; Mice; Rats; Rats, Sprague-Dawley; Reflex, Startle; Serotonin 5-HT2 Receptor Agonists; Stereotyped Behavior | 2009 |
Agmatine disrupts prepulse inhibition of acoustic startle reflex in rats.
Topics: Acoustic Stimulation; Agmatine; Analysis of Variance; Animals; Antipsychotic Agents; Apomorphine; Clozapine; Dibenzothiazepines; Dopamine Agonists; Haloperidol; Male; Quetiapine Fumarate; Rats; Rats, Wistar; Reflex, Startle; Sensory Gating | 2010 |
Synthesis and evaluation of a series of piperidine-2,6-dione-piperazine (piperidine) derivatives as multireceptor atypical antipsychotics.
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Clozapine; Disease Models, Animal; Dizocilpine Maleate; Mice; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Histamine H1; Receptors, Serotonin; Structure-Activity Relationship | 2012 |
Aquaporin-4 knockout abolishes apomorphine-induced tardive dyskinesia following chronic treatment with neuroleptics.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Antipsychotic Agents; Apomorphine; Aquaporin 4; Clozapine; Corpus Striatum; Disease Models, Animal; Glial Fibrillary Acidic Protein; Haloperidol; Hippocampus; Male; Mastication; Mice; Mice, Knockout; Motor Activity; Movement Disorders | 2012 |
Behavioral effects of clozapine, pimavanserin, and quetiapine in rodent models of Parkinson's disease and Parkinson's disease psychosis: evaluation of therapeutic ratios.
Topics: Amphetamine; Animals; Antiparkinson Agents; Antipsychotic Agents; Apomorphine; Clozapine; Dopamine; Dose-Response Relationship, Drug; Male; Parkinsonian Disorders; Piperidines; Psychotic Disorders; Quetiapine Fumarate; Rats; Rats, Sprague-Dawley; Urea | 2013 |
Effects of the nicotinic α7 receptor partial agonist GTS-21 on NMDA-glutamatergic receptor related deficits in sensorimotor gating and recognition memory in rats.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Apomorphine; Benzylidene Compounds; Clozapine; Cognition; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; GABA Antagonists; Haloperidol; Male; Nicotinic Agonists; Pyridines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Recognition, Psychology; Reflex, Startle; Sensory Gating | 2014 |
Standardized extract of Ficus platyphylla reverses apomorphine-induced changes in prepulse inhibition and locomotor activity in rats.
Topics: Analysis of Variance; Animals; Apomorphine; Clozapine; Dopamine Agonists; Dose-Response Relationship, Drug; Ficus; Male; Mice; Mice, Inbred C57BL; Motor Activity; Plant Bark; Plant Extracts; Prepulse Inhibition; Rats; Rats, Wistar | 2015 |
Differential effects of antipsychotic and propsychotic drugs on prepulse inhibition and locomotor activity in Roman high- (RHA) and low-avoidance (RLA) rats.
Topics: Amphetamines; Animals; Antipsychotic Agents; Apomorphine; Avoidance Learning; Clozapine; Dizocilpine Maleate; Dopamine Agonists; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Haloperidol; Locomotion; Male; Prepulse Inhibition; Rats; Receptor, Serotonin, 5-HT2A; Reflex, Startle; Schizophrenia; Serotonin 5-HT2 Receptor Agonists; Serotonin Antagonists | 2017 |