apis and phosphonic-acid

apis has been researched along with phosphonic-acid* in 1 studies

Other Studies

1 other study(ies) available for apis and phosphonic-acid

Article	Year
Efficient electrophilic fluorination for the synthesis of novel 2'-fluoro-3'-methyl-5'-deoxyphosphonic acid apiosyl nucleoside analogues. Nucleosides, nucleotides & nucleic acids, 2013, Volume: 32, Issue:10 Novel 5'-deoxyapiosyl purine phosphonic acid analogues with a 2'-electropositive moiety, such as, a fluorine atom were designed and synthesized from commercially available hydroxylacetone. Condensation of a glycosyl donor 10 with purines under Vorbruggen conditions and cross-metathesis give the desired nucleoside phosphonic acid analogues 14, 17, 21, and 24. The synthesized nucleoside analogues were subjected to antiviral screening against HIV-1, and the adenine analogue 17 exhibited weak in vitro anti-HIV-1 activity (EC50=26.6 μM). Topics: Antiviral Agents; Cell Line; Electrons; Halogenation; HIV-1; Models, Molecular; Molecular Conformation; Nucleosides; Pentoses; Phosphorous Acids	2013

Article

Year

Efficient electrophilic fluorination for the synthesis of novel 2'-fluoro-3'-methyl-5'-deoxyphosphonic acid apiosyl nucleoside analogues.

Nucleosides, nucleotides & nucleic acids, 2013, Volume: 32, Issue:10

Novel 5'-deoxyapiosyl purine phosphonic acid analogues with a 2'-electropositive moiety, such as, a fluorine atom were designed and synthesized from commercially available hydroxylacetone. Condensation of a glycosyl donor 10 with purines under Vorbruggen conditions and cross-metathesis give the desired nucleoside phosphonic acid analogues 14, 17, 21, and 24. The synthesized nucleoside analogues were subjected to antiviral screening against HIV-1, and the adenine analogue 17 exhibited weak in vitro anti-HIV-1 activity (EC50=26.6 μM).

Topics: Antiviral Agents; Cell Line; Electrons; Halogenation; HIV-1; Models, Molecular; Molecular Conformation; Nucleosides; Pentoses; Phosphorous Acids

2013