antipyrine and verapamil

antipyrine has been researched along with verapamil in 40 studies

Research

Studies (40)

Timeframe	Studies, this research(%)	All Research%
pre-1990	8 (20.00)	18.7374
1990's	2 (5.00)	18.2507
2000's	17 (42.50)	29.6817
2010's	12 (30.00)	24.3611
2020's	1 (2.50)	2.80

Authors

Authors	Studies
Danelian, E; Hämäläinen, MD; Hansson, A; Karlén, A; Karlsson, R; Lennernäs, H; Löfâs, S; Winiwarter, S	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Faassen, F; Spanings, H; Vogel, G; Vromans, H	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Caron, G; Ermondi, G	1
Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Conradi, R; Lee, PH; Shanmugasundaram, V	1
Campillo, NE; Guerra, A; Páez, JA	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Avdeef, A; Tam, KY	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Akamatsu, M	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U	1
Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Cho, HY; Jeon, YH; Jung, K; Kim, HS; Kim, K; Kim, S; Kwon, NH; Lee, JY; Lee, S; Seo, B; Suh, YG	1
Fujishiro, N; Kawata, H	1
Fruncillo, RA; Lener, ME; Rocci, ML; Sirgo, MA; Vlasses, PH	1
Abernethy, DR; Carrum, G; Dickinson, TH; Egan, JM	1
Mirvis, DM; Pieper, JA; Rutledge, DR	1
Bauer, LA; Davis, R; Greene, L; Horn, JR; Opheim, K; Stenwall, M	1
Bach, D; Blevins, R; Edwards, DJ; Kerner, N; Rubenfire, M	1
Kokurina, EV; Metelitsa, VI; Piotrovskii, VK; Riabokon, OS; Rumiantsev, DO; Slastnikova, ID	1
DeYoung, NJ; Duncan, HJ; Faris, IB	1
Brátová, M; Fendrich, Z; Hůlek, P; Macek, K; Vlcek, J	1
Baringer, JR; Raskin, NH	1
Bruhl, M; Rankin, LM	1
Hovda, DA; Lee, SM; Maeda, T	1
Bergman, E; Bondesson, U; Forsell, P; Hedeland, M; Knutson, L; Lennernäs, H; Petri, N	1
Boursier-Neyret, C; Carrupt, PA; Castella, ME; Delbos, JM; Mayer, JM; Reist, M; Testa, B; Turban, JJ; Walther, B	1
Fujita, T; Isomura, Y; Kamiya, M; Ogihara, T; Ohnishi, S; Ozawa, M; Yamamoto, A; Yamashita, S	1

Reviews

1 review(s) available for antipyrine and verapamil

Article	Year
Approach to the patient with migraine. Hospital practice (1995), 1996, Feb-15, Volume: 31, Issue:2 Topics: Analgesics, Non-Narcotic; Antipyrine; Chloral Hydrate; Drug Combinations; Drug Therapy, Combination; Ergotamine; Female; Humans; Menopause; Methylamines; Middle Aged; Migraine Disorders; Serotonin Receptor Agonists; Sumatriptan; Vasodilator Agents; Verapamil	1996

Trials

3 trial(s) available for antipyrine and verapamil

Article	Year
Comparative evaluation of the effects of labetalol, verapamil and diltiazem on antipyrine and indocyanine green clearances. Journal of clinical pharmacology, 1989, Volume: 29, Issue:10 Topics: Adult; Antipyrine; Diltiazem; Half-Life; Humans; Indocyanine Green; Labetalol; Male; Random Allocation; Verapamil	1989
Changes in antipyrine and indocyanine green kinetics during nifedipine, verapamil, and diltiazem therapy. Clinical pharmacology and therapeutics, 1986, Volume: 40, Issue:2 Topics: Adult; Antipyrine; Benzazepines; Biological Availability; Diltiazem; Drug Interactions; Female; Humans; Indocyanine Green; Kinetics; Liver; Male; Metabolic Clearance Rate; Nifedipine; Random Allocation; Verapamil	1986
Pharmacokinetic parameters of verapamil and its active metabolite norverapamil in patients with hepatopathy. Arzneimittel-Forschung, 1995, Volume: 45, Issue:2 Topics: Adult; Aged; Antipyrine; Breath Tests; Female; Half-Life; Humans; Hypertension, Portal; Liver Diseases; Male; Middle Aged; Verapamil	1995

Other Studies

36 other study(ies) available for antipyrine and verapamil

Article	Year
SPR biosensor studies of the direct interaction between 27 drugs and a liposome surface: correlation with fraction absorbed in humans. Journal of medicinal chemistry, 2000, Jun-01, Volume: 43, Issue:11 Topics: Humans; Intestinal Absorption; Liposomes; Pharmaceutical Preparations; Pharmacokinetics; Predictive Value of Tests; Surface Plasmon Resonance	2000
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. International journal of pharmaceutics, 2003, Sep-16, Volume: 263, Issue:1-2 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Caco-2 Cells; Cell Membrane Permeability; Heterocyclic Compounds; Humans; Protein Transport	2003
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9 Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water	2005
QSAR study on permeability of hydrophobic compounds with artificial membranes. Bioorganic & medicinal chemistry, 2007, Jun-01, Volume: 15, Issue:11 Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay. Bioorganic & medicinal chemistry letters, 2010, Jan-01, Volume: 20, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; Cell Line; Cell Membrane Permeability; Humans; Models, Biological; Quantitative Structure-Activity Relationship; Skin Absorption	2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9 Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Importance of physicochemical properties for the design of new pesticides. Journal of agricultural and food chemistry, 2011, Apr-13, Volume: 59, Issue:7 Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests	2012
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:2 Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1 Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Discovery of novel potent migrastatic Thiazolo[5,4-b]pyridines targeting Lysyl-tRNA synthetase (KRS) for treatment of Cancer metastasis. European journal of medicinal chemistry, 2021, Jun-05, Volume: 218 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Female; Humans; Lysine-tRNA Ligase; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Molecular Structure; Pyridines; Structure-Activity Relationship	2021
Twitch potentiation of frog (Rana japonica) skeletal muscle by antipyrine. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1989, Volume: 92, Issue:1 Topics: Action Potentials; Animals; Antipyrine; Calcium; Membrane Potentials; Microelectrodes; Muscle Contraction; Muscles; Nifedipine; Ranidae; Sarcoplasmic Reticulum; Verapamil	1989
Substrate-selective inhibition by verapamil and diltiazem: differential disposition of antipyrine and theophylline in humans. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 244, Issue:3 Topics: Adult; Antipyrine; Cytochrome P-450 Enzyme Inhibitors; Diltiazem; Drug Interactions; Female; Half-Life; Humans; Male; Metabolic Clearance Rate; Theophylline; Verapamil	1988
Effects of chronic phenobarbital on verapamil disposition in humans. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 246, Issue:1 Topics: Adult; Algorithms; Antipyrine; Humans; Male; Phenobarbital; Reference Values; Verapamil	1988
The effect of verapamil on antipyrine pharmacokinetics and metabolism in man. British journal of clinical pharmacology, 1986, Volume: 21, Issue:6 Topics: Adult; Antipyrine; Drug Interactions; Edaravone; Half-Life; Humans; Kinetics; Male; Metabolic Clearance Rate; Verapamil	1986
The effect of oral verapamil therapy on antipyrine clearance. British journal of clinical pharmacology, 1986, Volume: 22, Issue:5 Topics: Administration, Oral; Adult; Angina Pectoris; Antipyrine; Half-Life; Humans; Kinetics; Male; Middle Aged; Verapamil	1986
The effectiveness of local injections of vasodilating agents to produce vasodilation in subcutaneous tissue in rabbits. Clinical physiology (Oxford, England), 1985, Volume: 5, Issue:1 Topics: Alprostadil; Animals; Antipyrine; Dose-Response Relationship, Drug; Histamine; Injections, Subcutaneous; Iodine Radioisotopes; Methods; Microcirculation; Nitroprusside; Papaverine; Prostaglandins E; Rabbits; Regional Blood Flow; Vasodilation; Vasodilator Agents; Verapamil; Xenon Radioisotopes	1985
Migraine in older patients: a case report and management strategies. Geriatrics, 2000, Volume: 55, Issue:7 Topics: Acetaminophen; Aged; Aged, 80 and over; Antipyrine; Cheese; Chloral Hydrate; Diagnosis, Differential; Disease Management; Drug Combinations; Female; Food Hypersensitivity; Humans; Methylamines; Migraine Disorders; Verapamil; Wine	2000
Restoration of cerebral vasoreactivity by an L-type calcium channel blocker following fluid percussion brain injury. Journal of neurotrauma, 2005, Volume: 22, Issue:7 Topics: Animals; Antipyrine; Blood Pressure; Brain Injuries; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; Cerebral Arteries; Cerebrovascular Circulation; Disease Models, Animal; Male; Norepinephrine; Rats; Rats, Sprague-Dawley; Recovery of Function; Treatment Outcome; Vasoconstriction; Vasoconstrictor Agents; Verapamil	2005
First-pass effects of verapamil on the intestinal absorption and liver disposition of fexofenadine in the porcine model. Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:7 Topics: Animals; Antipyrine; Bile; Calcium Channel Blockers; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Intestinal Absorption; Liver; Models, Animal; Perfusion; Swine; Terfenadine; Verapamil	2006
Development of an in vitro rat intestine segmental perfusion model to investigate permeability and predict oral fraction absorbed. Pharmaceutical research, 2006, Volume: 23, Issue:7 Topics: Animals; Antipyrine; Dealkylation; In Vitro Techniques; Intestinal Absorption; Jejunum; Male; Models, Animal; Naproxen; Perfusion; Permeability; Pharmaceutical Preparations; Rats; Rats, Sprague-Dawley; Testosterone; Verapamil	2006
What kinds of substrates show P-glycoprotein-dependent intestinal absorption? Comparison of verapamil with vinblastine. Drug metabolism and pharmacokinetics, 2006, Volume: 21, Issue:3 Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Antipyrine; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Duodenum; Gene Expression; Humans; Ileum; Injections, Intravenous; Intestinal Absorption; Liver; Mannitol; Mice; Mice, Knockout; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tritium; Verapamil; Vinblastine	2006