antipyrine and ranitidine

antipyrine has been researched along with ranitidine in 35 studies

Research

Studies (35)

Timeframe	Studies, this research(%)	All Research%
pre-1990	11 (31.43)	18.7374
1990's	1 (2.86)	18.2507
2000's	13 (37.14)	29.6817
2010's	9 (25.71)	24.3611
2020's	1 (2.86)	2.80

Authors

Authors	Studies
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Faassen, F; Spanings, H; Vogel, G; Vromans, H	1
Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Avdeef, A; Tam, KY	1
Akamatsu, M	1
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Cho, HY; Jeon, YH; Jung, K; Kim, HS; Kim, K; Kim, S; Kwon, NH; Lee, JY; Lee, S; Seo, B; Suh, YG	1
Blaschke, TF; Espiritu-Quiza, MF; Skinner, MH	1
Akamatsu, K; Hirabayashi, Y; Kanaoka, M; Masumoto, S; Nakanishi, K; Nishinobu, M; Ohta, Y; Okada, S; Sakaue, H; Sasaki, T	1
Dicke, JM; Henderson, GI; Johnson, RF; Kuehl, TJ; Schenker, S	1
Kuroiwa, Y; Misawa, S; Nakamura, K; Tanaka, E	1
Crewe, HK; Lennard, MS; Tucker, GT; Woods, HF	1
Clarke, J; Dawson, P	1
Bell, GD; Henry, DA; Kitchingman, G; Langman, MJ; Macdonald, IA	1
de Vries, J; Kather, H; Simon, B; Staiger, C; Walter, E	1
Henry, DA; Langman, MJ	1
Breen, KJ; Bury, R; Desmond, PV; Mashford, ML; Morphett, B; Shaw, RG; Westwood, B	1
Kather, H; Simon, B; Staiger, C; Walter, E	1
Abernethy, DR; Eshelman, FN; Greenblatt, DJ; Shader, RI	1
Iwaki, M; Kawase, A; Tanino, T; Tsuji, A; Uno, S	1

Trials

2 trial(s) available for antipyrine and ranitidine

Article	Year
Cimetidine and ranitidine: comparison of effects on hepatic drug metabolism. British medical journal, 1980, Sep-20, Volume: 281, Issue:6243 Topics: Aminopyrine; Antipyrine; Cimetidine; Furans; Guanidines; Half-Life; Histamine H2 Antagonists; Humans; Microsomes, Liver; Ranitidine	1980
Ranitidine does not impair oxidative or conjugative metabolism: noninteraction with antipyrine, diazepam, and lorazepam. Clinical pharmacology and therapeutics, 1984, Volume: 35, Issue:2 Topics: Adult; Antipyrine; Biotransformation; Diazepam; Drug Interactions; Humans; Kinetics; Lorazepam; Male; Middle Aged; Random Allocation; Ranitidine	1984

Other Studies

33 other study(ies) available for antipyrine and ranitidine

Article	Year
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. International journal of pharmaceutics, 2003, Sep-16, Volume: 263, Issue:1-2 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Caco-2 Cells; Cell Membrane Permeability; Heterocyclic Compounds; Humans; Protein Transport	2003
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
QSAR study on permeability of hydrophobic compounds with artificial membranes. Bioorganic & medicinal chemistry, 2007, Jun-01, Volume: 15, Issue:11 Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9 Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis	2010
Importance of physicochemical properties for the design of new pesticides. Journal of agricultural and food chemistry, 2011, Apr-13, Volume: 59, Issue:7 Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic	2011
Prediction of drug intestinal absorption by new linear and non-linear QSPR. European journal of medicinal chemistry, 2011, Volume: 46, Issue:1 Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1 Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Discovery of novel potent migrastatic Thiazolo[5,4-b]pyridines targeting Lysyl-tRNA synthetase (KRS) for treatment of Cancer metastasis. European journal of medicinal chemistry, 2021, Jun-05, Volume: 218 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Female; Humans; Lysine-tRNA Ligase; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Molecular Structure; Pyridines; Structure-Activity Relationship	2021
Ranitidine alters antipyrine metabolism in control and phenobarbital-treated mice. Methods and findings in experimental and clinical pharmacology, 1990, Volume: 12, Issue:9 Topics: Animals; Antipyrine; Breath Tests; Cytochrome P-450 Enzyme System; Half-Life; Injections, Intraperitoneal; Liver; Male; Mice; Phenobarbital; Ranitidine	1990
Effects of prolonged oral cimetidine, ranitidine, and famotidine therapy on antipyrine elimination. Clinical therapeutics, 1987, Volume: 9, Issue:6 Topics: Administration, Oral; Adolescent; Adult; Aged; Antipyrine; Cimetidine; Famotidine; Female; Histamine H2 Antagonists; Humans; Liver; Male; Metabolic Clearance Rate; Middle Aged; Ranitidine; Thiazoles	1987
A comparative evaluation of the transport of H2-receptor antagonists by the human and baboon placenta. The American journal of the medical sciences, 1988, Volume: 295, Issue:3 Topics: Adolescent; Adult; Animals; Antipyrine; Biological Transport; Cimetidine; Famotidine; Female; Histamine H2 Antagonists; Humans; In Vitro Techniques; Maternal-Fetal Exchange; Nizatidine; Papio; Perfusion; Placenta; Pregnancy; Ranitidine; Thiazoles	1988
The effect of H2-receptor antagonists on antipyrine and pentobarbital metabolism in male and female rats. Japanese journal of pharmacology, 1988, Volume: 46, Issue:1 Topics: Animals; Antipyrine; Cimetidine; Famotidine; Female; Histamine H2 Antagonists; Male; Microsomes, Liver; Mixed Function Oxygenases; Pentobarbital; Ranitidine; Rats; Rats, Inbred Strains; Sex Factors; Thiazoles	1988
Metoprolol oxidation by rat liver microsomes. Inhibition by debrisoquine and other drugs. Biochemical pharmacology, 1986, Aug-15, Volume: 35, Issue:16 Topics: Animals; Antipyrine; Cimetidine; Debrisoquin; Guanidines; Isoquinolines; Metoprolol; Microsomes, Liver; Ranitidine; Rats; Rats, Inbred Strains	1986
A study to evaluate the effect of a course of ranitidine on antipyrine kinetics. Journal of clinical pharmacy and therapeutics, 1987, Volume: 12, Issue:1 Topics: Adult; Antipyrine; Drug Interactions; Half-Life; Humans; Male; Ranitidine	1987
[Influence of ranitidine on antipyrine metabolism (author's transl)]. Zeitschrift fur Gastroenterologie, 1980, Volume: 18, Issue:12 Topics: Adult; Antipyrine; Female; Furans; Half-Life; Histamine H2 Antagonists; Humans; Male; Ranitidine; Time Factors	1980
The effects of H2 receptor antagonists on hepatic drug metabolism. Scandinavian journal of gastroenterology. Supplement, 1981, Volume: 69 Topics: Adult; Aminopyrine; Antipyrine; Breath Tests; Cimetidine; Furans; Guanidines; Histamine H2 Antagonists; Humans; Liver; Middle Aged; Ranitidine; Structure-Activity Relationship	1981
Effects of cimetidine and ranitidine on hepatic drug metabolism. Clinical pharmacology and therapeutics, 1982, Volume: 31, Issue:3 Topics: Adult; Antipyrine; Cimetidine; Drug Interactions; Female; Furans; Guanidines; Half-Life; Histamine H2 Antagonists; Humans; Liver; Male; Mixed Function Oxygenases; Ranitidine; Theophylline	1982
Influence of ranitidine on antipyrine pharmacokinetics in healthy volunteers. Digestive diseases and sciences, 1980, Volume: 25, Issue:11 Topics: Antipyrine; Drug Interactions; Furans; Humans; Peptic Ulcer; Ranitidine	1980
Decreased intestinal CYP3A and P-glycoprotein activities in rats with adjuvant arthritis. Drug metabolism and pharmacokinetics, 2007, Volume: 22, Issue:4 Topics: Animals; Antipyrine; Arthritis, Experimental; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Blotting, Western; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Diffusion Chambers, Culture; Female; Fluorescent Dyes; In Vitro Techniques; Intestinal Mucosa; Intestines; Microsomes; Midazolam; Ranitidine; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Rhodamine 123; RNA, Messenger	2007