antipyrine and propranolol

antipyrine has been researched along with propranolol in 89 studies

Research

Studies (89)

Timeframe	Studies, this research(%)	All Research%
pre-1990	40 (44.94)	18.7374
1990's	10 (11.24)	18.2507
2000's	23 (25.84)	29.6817
2010's	15 (16.85)	24.3611
2020's	1 (1.12)	2.80

Authors

Authors	Studies
Blake, JF; Curatolo, WJ; Lombardo, F	1
Coassolo, P; Lavé, T; Schneider, G	1
Danelian, E; Hämäläinen, MD; Hansson, A; Karlén, A; Karlsson, R; Lennernäs, H; Löfâs, S; Winiwarter, S	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Artursson, P; Bergström, CA; Matsson, P; Nagahara, N; Norinder, U; Tavelin, S	1
Caron, G; Ermondi, G	1
Jolivette, LJ; Ward, KW	1
Carrupt, PA; Martel, S; Ottaviani, G	1
Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R	1
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Campillo, NE; Guerra, A; Páez, JA	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Avdeef, A; Tam, KY	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Akamatsu, M	1
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A	1
Crawford, DH; Fletcher, LM; Li, P; Roberts, MS; Robertson, TA; Thorling, CA; Zhang, Q	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U	1
Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bending, MR; Dollery, CT; Kahn, GC; Mucklow, JC	1
Paumgartner, G	1
Adamska-Dyniewska, H; Gajewska, B	1
Branch, RA; Gerber, JG; Shand, DG; Villeneuve, JP; Wilson, JT	1
Anttila, M; Järvensivu, P; Pelkonen, RO; Sotaniemi, EA; Sundquist, H	1
Franke, K; Greenblatt, DJ; Huffman, DH	1
Obel, AO; Vere, DW	1
Powis, G; Snow, DH	1
Humphries, TJ	1
Karim, A; Nicholson, PA; Smith, M	1
Baraka, OZ; Ford, JM; Roberts, CJ; Truman, CA	1
Belpaire, FM; Bogaert, MG; Chauvelot-Moachon, L; de Smet, F; Rosseel, MT; Vermeulen, AM; Vynckier, LJ	1
Hansen, JM; Jørgensen, B; Kayser, L; Perrild, H; Poulsen, HE; Skovsted, L	1
Becker, A; Bołdys, H; Hartleb, M; Kloc, T; Mańczyk, I	1
Belpaire, FM; Bogaert, MG; Chindavijak, B; de Smet, F; Fraeyman, N	1
Bouchier, IA; Hayes, PC	1
Bryan, RM; Hollinger, BR	1
Belpaire, FM; Bogaert, MG; Chindavijak, B	3
Bennett, PN; Fenn, GC; Notarianni, LJ	1
Weissel, M	1
Bołdys, H; Hartleb, M; Kacperek, T; Markiewicz, A; Nowak, S; Rudzki, K	1
Belpaire, FM; Bogaert, MG; Chindavijak, B; De Smet, F	1
Knowlton, PW; Svensson, CK; Ware, JA	1
Alván, G	1
Shrewsbury, RP	1
Kaszubski, P; Orszulak-Michalak, D	1
Horváth, T; Jávor, T; Rechenbach, C; Traeger, A	1
Hanano, M; Iga, T; Sawada, Y; Sugiyama, Y	1
Bax, ND; Jones, RW; Lennard, MS; Tucker, GT; Woods, HF	1
Branch, RA; Nies, AS; Shand, DG; Wilkinson, GR	1
Cheong, DK; Gangarosa, LP	1
Branch, RA; James, JA; Read, AE	1
Branch, RA; Nies, AS; Shand, DG	1
Bax, ND; Lennard, MS; Tucker, GT	1
Branch, RA; Herman, RJ	1
Luczynska, C; Wilson, K	1
Vesell, ES	1
Bercoff, E; Larrey, D; Lebrec, D; Pessayre, D	1
Abramson, FP; Bai, SA; Robinson, D	1
Daneshmend, TK; Roberts, CJ	1
Belpaire, FM; De Rick, A; Rosseel, MT	1
Ishizaki, T; Tawara, K	1
Nadai, T; Sakane, T; Taki, Y; Yamashita, S; Yoshida, M	1
Fenyves, D; Gariépy, L; Villeneuve, JP	1
Abernethy, DR; Greenblatt, DJ; Kaplan, MM; von Moltke, LL	1
Abraham, MH; Bradbury, MW; Chadha, HS; Gratton, JA	1
Chang, P; Hung, DY; Roberts, MS; Siebert, GA	1
Avram, MJ; Henthorn, TK; Krejcie, TC; Niemann, CU	1
Aungst, B; Dobson, G; Hidalgo, I; Letendre, L; Scott, M	1
Charman, SA; Katneni, K; Porter, CJ	1
Bansal, T; Jaggi, M; Khar, RK; Mishra, G; Mukherjee, R; Singh, M; Talegaonkar, S	1
Fontaine, F; Goh, LA; Khlentzos, AM; Liu, X; Nikolovski, J; Roberts, MS; Wang, JY	1
Crawford, DH; Fletcher, LM; Li, P; Roberts, MS; Robertson, TA; Weiss, M; Zhang, Q	1
Collares, EF; Vinagre, AM	1
Chang, H; Chen, C; Du, H; Guan, C; Li, C; Qiu, L; Wang, S; Wang, T; Wu, Y; Zhang, L; Zhang, S; Zhou, H	1

Reviews

7 review(s) available for antipyrine and propranolol

Article	Year
Clinical implications of drug interactions with the cytochrome P-450 enzyme system associated with omeprazole. Digestive diseases and sciences, 1991, Volume: 36, Issue:12 Topics: Aminopyrine; Animals; Antipyrine; Cytochrome P-450 Enzyme System; Diazepam; Drug Interactions; Humans; Omeprazole; Phenytoin; Propranolol; Theophylline; Warfarin	1991
[Modification of peripheral thyroid hormone metabolism by drugs]. Acta medica Austriaca, 1988, Volume: 15 Suppl 1 Topics: Amiodarone; Antipyrine; Dexamethasone; Heparin; Humans; Phenobarbital; Phenytoin; Propranolol; Protein Binding; Rifampin; Thiouracil; Thyroxine; Thyroxine-Binding Proteins; Triiodothyronine	1988
Ethnic differences in reactions to drugs and xenobiotics. Other protein variants with pharmacogenetic consequences: albumin and orosomucoid. Progress in clinical and biological research, 1986, Volume: 214 Topics: Antipyrine; Binding Sites; Humans; Metabolic Clearance Rate; Metabolism, Inborn Errors; Orosomucoid; Pharmaceutical Preparations; Phenotype; Polymorphism, Genetic; Propranolol; Protein Binding; Serum Albumin; Warfarin	1986
Prediction of the disposition of nine weakly acidic and six weakly basic drugs in humans from pharmacokinetic parameters in rats. Journal of pharmacokinetics and biopharmaceutics, 1985, Volume: 13, Issue:5 Topics: Animals; Antipyrine; Barbiturates; Biological Availability; Chlorpromazine; Diazepam; Drug Evaluation; Female; Half-Life; Humans; Kinetics; Male; Metabolic Clearance Rate; Pentazocine; Pharmaceutical Preparations; Phenylbutazone; Phenytoin; Propranolol; Quinidine; Rats; Species Specificity; Tissue Distribution; Tolbutamide; Valproic Acid; Warfarin	1985
Hemodynamic drug interactions. Cardiovascular clinics, 1974, Volume: 6, Issue:2 Topics: Animals; Antipyrine; Dogs; Dopamine; Drug Interactions; Enzyme Induction; Glucagon; Half-Life; Hemodynamics; Humans; Lidocaine; Liver Circulation; Macaca mulatta; Metabolic Clearance Rate; Oxyphenbutazone; Pharmaceutical Preparations; Phenobarbital; Propranolol; Time Factors	1974
The clinical significance of the effects of cigarette smoking on drug disposition. Methods and findings in experimental and clinical pharmacology, 1983, Volume: 5, Issue:7 Topics: Acetaminophen; Antipyrine; Benzodiazepines; Chlorpromazine; Clomipramine; Codeine; Humans; Pharmaceutical Preparations; Phenacetin; Propranolol; Smoking; Theophylline; Warfarin	1983
Noninvasive assessment in vivo of hepatic drug metabolism in health and disease. Annals of the New York Academy of Sciences, 1984, Volume: 428 Topics: Adult; Aminopyrine; Animals; Antipyrine; Breath Tests; Humans; Liver; Liver Cirrhosis; Liver Diseases; Liver Function Tests; Male; Mixed Function Oxygenases; Pharmaceutical Preparations; Propranolol; Rats; Saliva	1984

Trials

5 trial(s) available for antipyrine and propranolol

Article	Year
The effect of propranolol on paracetamol metabolism in man. British journal of clinical pharmacology, 1990, Volume: 29, Issue:2 Topics: Acetaminophen; Adult; Antipyrine; Chromatography, High Pressure Liquid; Double-Blind Method; Drug Interactions; Female; Half-Life; Humans; Male; Propranolol	1990
Differential effect of continuous administration of beta-adrenoceptor antagonists on antipyrine and phenytoin clearance. British journal of clinical pharmacology, 1989, Volume: 28, Issue:5 Topics: Adrenergic beta-Antagonists; Adult; Antipyrine; Atenolol; Humans; Male; Metoprolol; Phenytoin; Propranolol	1989
Potential drug interactions with misoprostol: effects on the pharmacokinetics of antipyrine and propranolol. Postgraduate medical journal, 1988, Volume: 64 Suppl 1 Topics: Adult; Alprostadil; Anti-Ulcer Agents; Antipyrine; Drug Interactions; Female; Half-Life; Humans; Male; Misoprostol; Propranolol	1988
Inhibition of antipyrine metabolism by beta-adrenoceptor antagonists. British journal of clinical pharmacology, 1981, Volume: 12, Issue:6 Topics: Adrenergic beta-Antagonists; Adult; Antipyrine; Depression, Chemical; Humans; Kinetics; Male; Metoprolol; Propranolol; Terbutaline	1981
Beta-adrenergic blockade affects initial drug distribution due to decreased cardiac output and altered blood flow distribution. The Journal of pharmacology and experimental therapeutics, 2004, Volume: 311, Issue:2 Topics: Adrenergic beta-Antagonists; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Cardiac Output; Drug Interactions; Humans; Indocyanine Green; Male; Propranolol; Regional Blood Flow	2004

Other Studies

77 other study(ies) available for antipyrine and propranolol

Article	Year
Computation of brain-blood partitioning of organic solutes via free energy calculations. Journal of medicinal chemistry, 1996, Nov-22, Volume: 39, Issue:24 Topics: Animals; Blood-Brain Barrier; Brain; Cattle; Cells, Cultured; Endothelium, Vascular; Membrane Lipids; Microcirculation; Molecular Conformation; Molecular Structure; Monte Carlo Method; Permeability; Pharmaceutical Preparations; Software; Solubility; Thermodynamics	1996
Combining in vitro and in vivo pharmacokinetic data for prediction of hepatic drug clearance in humans by artificial neural networks and multivariate statistical techniques. Journal of medicinal chemistry, 1999, Dec-16, Volume: 42, Issue:25 Topics: Animals; Biological Availability; Dogs; Humans; Least-Squares Analysis; Liver; Multivariate Analysis; Neural Networks, Computer; Pharmacokinetics; Rats	1999
SPR biosensor studies of the direct interaction between 27 drugs and a liposome surface: correlation with fraction absorbed in humans. Journal of medicinal chemistry, 2000, Jun-01, Volume: 43, Issue:11 Topics: Humans; Intestinal Absorption; Liposomes; Pharmaceutical Preparations; Pharmacokinetics; Predictive Value of Tests; Surface Plasmon Resonance	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Exploring the role of different drug transport routes in permeability screening. Journal of medicinal chemistry, 2005, Jan-27, Volume: 48, Issue:2 Topics: Administration, Oral; Biological Transport; Caco-2 Cells; Cell Line; Humans; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Membranes, Artificial; Models, Biological; Molecular Conformation; Monte Carlo Method; Permeability; Pharmaceutical Preparations; Pharmacokinetics	2005
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9 Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water	2005
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. Journal of pharmaceutical sciences, 2005, Volume: 94, Issue:7 Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution	2005
In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities. Journal of medicinal chemistry, 2007, Feb-22, Volume: 50, Issue:4 Topics: Humans; Membranes, Artificial; Models, Biological; Models, Molecular; Octanols; Permeability; Pharmaceutical Preparations; Skin Absorption; Water	2007
QSAR study on permeability of hydrophobic compounds with artificial membranes. Bioorganic & medicinal chemistry, 2007, Jun-01, Volume: 15, Issue:11 Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship	2007
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds. Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22 Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9 Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Importance of physicochemical properties for the design of new pesticides. Journal of agricultural and food chemistry, 2011, Apr-13, Volume: 59, Issue:7 Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic	2011
Prediction of drug intestinal absorption by new linear and non-linear QSPR. European journal of medicinal chemistry, 2011, Volume: 46, Issue:1 Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics	2011
Hepatic pharmacokinetics of cationic drugs in a high-fat emulsion-induced rat model of nonalcoholic steatohepatitis. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:4 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Cations; Cytochrome P-450 Enzyme System; Disease Models, Animal; Emulsions; Fats; Fatty Liver; Liver; Liver Cirrhosis; Male; Non-alcoholic Fatty Liver Disease; Rats; Rats, Wistar	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests	2012
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:2 Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1 Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Drug concentration in saliva. Clinical pharmacology and therapeutics, 1978, Volume: 24, Issue:5 Topics: Adolescent; Adult; Aged; Antipyrine; Chlorpropamide; Humans; Hydrogen-Ion Concentration; Male; Meperidine; Middle Aged; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Propranolol; Protein Binding; Saliva; Tolbutamide	1978
[Drug metabolism in liver diseases]. Zeitschrift fur Gastroenterologie. Verhandlungsband, 1979, Volume: 16 Topics: Antipyrine; Biological Availability; Biotransformation; Diazepam; Humans; Liver; Liver Diseases; Pharmaceutical Preparations; Propranolol; Protein Binding	1979
[Effect of propranolol on the ability of the liver to metabolize drugs in patients with hypertension]. Kardiologia polska, 1979, Volume: 22, Issue:1 Topics: Adult; Aged; Antipyrine; Female; Humans; Hypertension; Indocyanine Green; Liver; Male; Middle Aged; Propranolol	1979
Drug metabolism in rats bearing a pituitary mammotropic tumor. The Journal of pharmacology and experimental therapeutics, 1979, Volume: 209, Issue:1 Topics: Aminopyrine; Animals; Antipyrine; Cardiac Output; Half-Life; Liver; Male; Mammary Glands, Animal; Neoplasms, Experimental; Pharmaceutical Preparations; Pituitary Neoplasms; Propranolol; Rats; Rats, Inbred F344; Regional Blood Flow	1979
Plasma clearance of propranolol and sotalol and hepatic drug-metabolizing enzyme activity. Clinical pharmacology and therapeutics, 1979, Volume: 26, Issue:2 Topics: Adult; Aged; Angina Pectoris; Antipyrine; Cytochrome P-450 Enzyme System; Female; Half-Life; Humans; Hypertension; Liver; Male; Middle Aged; Propranolol; Sotalol	1979
Impairment of antipyrine clearance in humans by propranolol. Circulation, 1978, Volume: 57, Issue:6 Topics: Adult; Antipyrine; Female; Half-Life; Humans; Male; Propranolol	1978
Antipyrine and propranolol disposition in malnutrition. East African medical journal, 1978, Volume: 55, Issue:1 Topics: Adult; Antipyrine; Humans; Middle Aged; Nutrition Disorders; Propranolol	1978
The effects of exercise and adrenaline infusion upon the blood levels of propranolol and antipyrine in the horse. The Journal of pharmacology and experimental therapeutics, 1978, Volume: 205, Issue:3 Topics: Animals; Antipyrine; Blood Proteins; Drug Interactions; Epinephrine; Horses; Physical Exertion; Propranolol; Protein Binding; Time Factors	1978
Pharmacokinetics of misoprostol in the elderly, in patients with renal failure and when coadministered with NSAID or antipyrine, propranolol or diazepam. The Journal of rheumatology. Supplement, 1990, Volume: 20 Topics: Adult; Aged; Aging; Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Diazepam; Drug Interactions; Humans; Kidney Failure, Chronic; Liver; Misoprostol; Propranolol	1990
Effect of aging on the pharmcokinetics of atenolol, metoprolol and propranolol in the rat. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 254, Issue:1 Topics: Aging; Animals; Antipyrine; Atenolol; Male; Metabolic Clearance Rate; Metoprolol; Orosomucoid; Propranolol; Rats; Rats, Inbred Strains	1990
[Usefulness of the evaluation of blood supply and mass of the liver for predicting the rate of pharmacokinetics of lidocaine, propranolol and phenazone]. Polskie Archiwum Medycyny Wewnetrznej, 1989, Volume: 81, Issue:6 Topics: Adult; Aged; Antipyrine; Female; Humans; Lidocaine; Liver; Liver Circulation; Liver Cirrhosis; Male; Metabolic Clearance Rate; Middle Aged; Portal System; Propranolol	1989
Effect of turpentine-induced inflammation on the disposition kinetics of propranolol, metoprolol, and antipyrine in the rat. Fundamental & clinical pharmacology, 1989, Volume: 3, Issue:2 Topics: Administration, Oral; Animals; Antipyrine; Inflammation; Injections, Intravenous; Male; Metoprolol; Orosomucoid; Propranolol; Protein Binding; Rats; Rats, Inbred Strains; Turpentine	1989
Effect of acute and chronic propranolol administration on antipyrine and paracetamol clearance in patients with chronic liver disease. The American journal of gastroenterology, 1989, Volume: 84, Issue:7 Topics: Acetaminophen; Adult; Aged; Antipyrine; Chronic Disease; Drug Administration Schedule; Female; Humans; Liver Diseases; Male; Metabolic Clearance Rate; Middle Aged; Propranolol	1989
Beta-receptor-mediated increase in cerebral blood flow during hypoglycemia. The American journal of physiology, 1987, Volume: 253, Issue:4 Pt 2 Topics: Animals; Antipyrine; Blood Glucose; Cerebellum; Cerebrovascular Circulation; Hypoglycemia; Hypothalamus; Insulin; Male; Propranolol; Pyramidal Tracts; Rats; Receptors, Adrenergic, beta	1987
In-vitro biotransformation of antipyrine, lignocaine and propranolol in the liver of rats with turpentine-induced inflammation. The Journal of pharmacy and pharmacology, 1987, Volume: 39, Issue:11 Topics: Aminopyrine N-Demethylase; Animals; Antipyrine; Biotransformation; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Hepatitis, Animal; In Vitro Techniques; Lidocaine; Liver; Male; Propranolol; Rats; Rats, Inbred Strains; Turpentine	1987
Effect of inflammation and proadifen on the disposition of antipyrine, lignocaine and propranolol in rat isolated perfused liver. The Journal of pharmacy and pharmacology, 1987, Volume: 39, Issue:12 Topics: Animals; Antipyrine; In Vitro Techniques; Inflammation; Lidocaine; Liver; Male; Proadifen; Propranolol; Rats; Rats, Inbred Strains; Turpentine	1987
[Clinical variability of hepatic clearance of antipyrine and Tc-99m-HIDA in healthy persons and in those with liver diseases. II. Effect of propranolol]. Polskie Archiwum Medycyny Wewnetrznej, 1987, Volume: 77, Issue:6 Topics: Adult; Antipyrine; Circadian Rhythm; Contrast Media; Female; Humans; Imino Acids; Liver; Liver Diseases; Male; Metabolic Clearance Rate; Middle Aged; Organotechnetium Compounds; Propranolol; Technetium Tc 99m Lidofenin	1987
Effect of inflammation on the metabolism of antipyrine, lidocaine and propranolol in isolated rat hepatocytes. Pharmacology, 1988, Volume: 36, Issue:4 Topics: Animals; Antipyrine; Inflammation; Lidocaine; Liver; Male; Proadifen; Propranolol; Rats; Rats, Inbred Strains; Turpentine	1988
Alteration of the pharmacokinetics and metabolism of propranolol and antipyrine elicited by indwelling catheters in the rat. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 246, Issue:3 Topics: Animals; Antipyrine; Catheters, Indwelling; Male; Propranolol; Protein Binding; Rats; Rats, Inbred Strains	1988
Effect of hydralazine on the elimination of antipyrine in the rat. Pharmaceutical research, 1987, Volume: 4, Issue:6 Topics: Administration, Oral; Animals; Antipyrine; Biological Availability; Body Temperature; Drug Synergism; Hydralazine; Metoprolol; Propranolol; Rats; Rats, Inbred Strains	1987
Effect of Fluosol-DA hemodilution on the kinetics of hepatically eliminated drugs. Research communications in chemical pathology and pharmacology, 1987, Volume: 55, Issue:3 Topics: Animals; Antipyrine; Blood Substitutes; Drug Combinations; Fluorocarbons; Hemodilution; Hydroxyethyl Starch Derivatives; Indocyanine Green; Kinetics; Liver; Pharmaceutical Preparations; Phenytoin; Propranolol; Rats	1987
The influence of propranolol and glucagon on the pharmacokinetics of antipyrine and sodium salicylate. Die Pharmazie, 1987, Volume: 42, Issue:6 Topics: Animals; Antipyrine; Female; Glucagon; Half-Life; Liver Circulation; Male; Propranolol; Rabbits; Salicylates; Salicylic Acid	1987
Beta-adrenoceptor blocking drugs and cytochrome P-450: the influence of propranolol treatment on caffeine, antipyrine, D-glucaric acid and indocyanine green elimination in patients with hepatic disorders. International journal of clinical pharmacology research, 1986, Volume: 6, Issue:3 Topics: Adult; Antipyrine; Caffeine; Cytochrome P-450 Enzyme System; Female; Glucaric Acid; Humans; Indocyanine Green; Liver Diseases, Alcoholic; Male; Middle Aged; Propranolol	1986
Penbutolol and propranolol: a comparison of their effects on antipyrine clearance in man. British journal of clinical pharmacology, 1985, Volume: 19, Issue:5 Topics: Adult; Antipyrine; Half-Life; Heart Rate; Humans; Kinetics; Male; Penbutolol; Physical Exertion; Propanolamines; Propranolol; Saliva; Stereoisomerism	1985
Increased clearance of antipyrine and d-propranolol after phenobarbital treatment in the monkey. Relative contributions of enzyme induction and increased hepatic blood flow. The Journal of clinical investigation, 1974, Volume: 53, Issue:4 Topics: Animals; Antipyrine; Blood Flow Velocity; Cardiac Output; Enzyme Induction; Half-Life; Haplorhini; Kinetics; Liver; Liver Circulation; Macaca; Male; Metabolic Clearance Rate; Microspheres; Organ Size; Phenobarbital; Propranolol	1974
The effects of adrenergic drugs and blockers upon the efficiency of isotope clearance from the subcutaneous tissues of the cat. Archives internationales de pharmacodynamie et de therapie, 1969, Volume: 179, Issue:2 Topics: Adipose Tissue; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Animals; Antipyrine; Capillary Resistance; Cats; Epinephrine; Injections, Subcutaneous; Iodine Isotopes; Isoproterenol; Papaverine; Phenoxybenzamine; Phosphates; Phosphorus Isotopes; Propranolol; Sympatholytics; Sympathomimetics	1969
Proceedings: The influence of chronic liver disease on the elimination of d-propranolol, anti-pyrine, and indocyanine green. Gut, 1974, Volume: 15, Issue:10 Topics: Administration, Oral; Antipyrine; Bilirubin; Chronic Disease; Humans; Indocyanine Green; Liver; Liver Diseases; Propranolol; Serum Albumin	1974
Enzyme induction and beta-adrenergic receptor blocking drugs. British journal of clinical pharmacology, 1984, Volume: 17 Suppl 1 Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Antipyrine; Drug Interactions; Enzyme Induction; Half-Life; Humans; Kinetics; Middle Aged; Phenobarbital; Propranolol; Rifampin; Smoking	1984
Propranolol does not further decrease the clearance of antipyrine in patients with alcoholic cirrhosis. Clinical science (London, England : 1979), 1983, Volume: 65, Issue:2 Topics: Adult; Antipyrine; Gastrointestinal Hemorrhage; Humans; Liver Cirrhosis, Alcoholic; Male; Metabolic Clearance Rate; Middle Aged; Propranolol; Recurrence	1983
Relationships between propranolol plasma protein binding, glycoprotein concentration, and enzyme induction following phenobarbital administration in the dog. Biochemical pharmacology, 1983, Sep-01, Volume: 32, Issue:17 Topics: Animals; Antipyrine; Blood Proteins; Cytochrome P-450 Enzyme System; Dogs; Glycoproteins; Half-Life; Kinetics; Male; Orosomucoid; Phenobarbital; Propranolol	1983
The short term effects of propranolol, atenolol and labetalol on antipyrine kinetics in normal subjects. British journal of clinical pharmacology, 1982, Volume: 13, Issue:6 Topics: Adult; Antipyrine; Atenolol; Drug Interactions; Female; Half-Life; Humans; Kinetics; Labetalol; Male; Propranolol; Sympatholytics	1982
Enhanced plasma binding of propranolol and oxprenolol and induction of hexobarbital and antipyrine metabolism by rifampicin treatment in the dog. Archives internationales de pharmacodynamie et de therapie, 1982, Volume: 259, Issue:2 Topics: Animals; Antipyrine; Blood Proteins; Dogs; Female; Half-Life; Hexobarbital; Male; Oxprenolol; Propranolol; Protein Binding; Rifampin	1982
Absence of changes in drug disposition and catecholamine sensitivity in the hyperthyroid dog. British journal of pharmacology, 1980, Volume: 71, Issue:1 Topics: Animals; Antipyrine; Catecholamines; Dogs; Female; Heart Rate; Hyperthyroidism; Kinetics; Male; Pharmaceutical Preparations; Phenobarbital; Propranolol	1980
Kinetic analysis of the drug permeation process across the intestinal epithelium. Pharmaceutical research, 1994, Volume: 11, Issue:11 Topics: Animals; Antipyrine; Imipramine; Intestinal Mucosa; Male; Mannitol; Permeability; Pharmacokinetics; Propranolol; Rats; Rats, Wistar; Water	1994
Clearance by the liver in cirrhosis. I. Relationship between propranolol metabolism in vitro and its extraction by the perfused liver in the rat. Hepatology (Baltimore, Md.), 1993, Volume: 17, Issue:2 Topics: Animals; Antipyrine; Carbon Tetrachloride; Chlorpromazine; In Vitro Techniques; Liver; Liver Circulation; Liver Cirrhosis, Experimental; Male; Perfusion; Propranolol; Rats; Rats, Sprague-Dawley	1993
Antipyrine kinetics in patients with primary biliary cirrhosis. Journal of clinical pharmacology, 1993, Volume: 33, Issue:1 Topics: Adult; Aged; Antipyrine; Bilirubin; Female; Half-Life; Humans; Infusions, Intravenous; Liver Cirrhosis, Biliary; Male; Metabolic Clearance Rate; Middle Aged; Propranolol	1993
Molecular factors influencing drug transfer across the blood-brain barrier. The Journal of pharmacy and pharmacology, 1997, Volume: 49, Issue:12 Topics: 2-Propanol; Animals; Antipyrine; Biological Transport; Blood-Brain Barrier; Capillary Permeability; Erythritol; Estradiol; Ethanol; Ethylene Glycol; Female; Kinetics; Linear Models; Mannitol; Models, Biological; Organic Chemicals; Propranolol; Rats; Rats, Wistar; Solubility; Sucrose; Thiourea; Thymine; Urea	1997
Ion-trapping, microsomal binding, and unbound drug distribution in the hepatic retention of basic drugs. The Journal of pharmacology and experimental therapeutics, 2004, Volume: 308, Issue:1 Topics: Animals; Antipyrine; Atenolol; Hydrogen-Ion Concentration; Liver; Male; Microsomes, Liver; Models, Biological; Propranolol; Rats; Rats, Wistar	2004
Evaluating barriers to bioavailability in vivo: validation of a technique for separately assessing gastrointestinal absorption and hepatic extraction. Pharmaceutical research, 2004, Volume: 21, Issue:8 Topics: Amoxicillin; Animals; Antipyrine; Area Under Curve; Atenolol; Biological Availability; Gastrointestinal Tract; Intestinal Absorption; Liver; Male; Models, Animal; Propranolol; Rats; Rats, Sprague-Dawley; Testosterone	2004
Permeability assessment of poorly water-soluble compounds under solubilizing conditions: the reciprocal permeability approach. Journal of pharmaceutical sciences, 2006, Volume: 95, Issue:10 Topics: Animals; Antipyrine; Cinnarizine; Diazepam; Glycerol; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Jejunum; Male; Micelles; Naproxen; Permeability; Polysorbates; Propranolol; Rats; Rats, Sprague-Dawley; Solubility; Water	2006
Concurrent determination of topotecan and model permeability markers (atenolol, antipyrine, propranolol and furosemide) by reversed phase liquid chromatography: utility in Caco-2 intestinal absorption studies. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, Nov-15, Volume: 859, Issue:2 Topics: Antipyrine; Atenolol; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Chromatography, High Pressure Liquid; Drug Stability; Furosemide; Humans; Intestinal Absorption; Permeability; Propranolol; Reproducibility of Results; Sensitivity and Specificity; Topotecan	2007
Influence of perfusate composition on drug disposition in the in-situ perfused rat lung. International journal of pharmaceutics, 2009, Dec-01, Volume: 382, Issue:1-2 Topics: Animals; Antipyrine; Atenolol; Buffers; Carbon Radioisotopes; Deuterium Oxide; Dextrans; Evans Blue; Hydrogen-Ion Concentration; Indicator Dilution Techniques; Lung; Male; Models, Biological; Morpholines; Perfusion; Permeability; Pressure; Propranolol; Rats; Rats, Wistar; Serum Albumin, Bovine; Sucrose	2009
Hepatocellular necrosis, fibrosis and microsomal activity determine the hepatic pharmacokinetics of basic drugs in right-heart-failure-induced liver damage. Pharmaceutical research, 2012, Volume: 29, Issue:6 Topics: Adrenergic Antagonists; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Atenolol; Cell Membrane Permeability; Cytochrome P-450 Enzyme System; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Heart Failure; Labetalol; Linear Models; Liver; Liver Cirrhosis; Liver Diseases; Male; Metabolic Clearance Rate; Metoprolol; Microsomes, Liver; Models, Biological; Necrosis; Nonlinear Dynamics; Perfusion; Propranolol; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction	2012
Evidence for the involvement of peripheral β-adrenoceptors in delayed liquid gastric emptying induced by dipyrone, 4-aminoantipyrine, and antipyrine in rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2013, Volume: 46, Issue:9 Topics: Adrenergic Antagonists; Ampyrone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Dipyrone; Gastric Emptying; Infusions, Intraventricular; Male; Phenolsulfonphthalein; Prazosin; Propranolol; Rats, Wistar; Receptors, Adrenergic, beta; Yohimbine	2013
Effects of membrane transport activity and cell metabolism on the unbound drug concentrations in the skeletal muscle and liver of drugs: A microdialysis study in rats. Pharmacology research & perspectives, 2021, Volume: 9, Issue:5 Topics: Animals; Antipyrine; Atenolol; Carbamazepine; Cell Membrane; Digoxin; Diltiazem; Diphenhydramine; Drug Elimination Routes; Gabapentin; Lamotrigine; Liver; Memantine; Membrane Transport Proteins; Microdialysis; Muscle, Skeletal; Ofloxacin; Pharmaceutical Preparations; Propranolol; Pyrilamine; Quinidine; Rats; Terfenadine	2021