Compounds > antipyrine

antipyrine and probenecid

antipyrine has been researched along with probenecid in 14 studies

Research

Studies (14)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (28.57)	18.7374
1990's	1 (7.14)	18.2507
2000's	5 (35.71)	29.6817
2010's	4 (28.57)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Brockmeyer, NH; Goos, M; Klimek, K; Mertins, L; Ohnhaus, EE	1
Bammel, A; Kirch, W; Mönig, H; Ohnhaus, EE; Zurborn, KH	1
Brockmeyer, NH; Heidemann, H; Ohnhaus, EE	1
Burns, JJ; Harrison, YE; Welch, RM	1
KUNIN, CM	1
Hakala, KE; Heikkinen, TM; Laine, KP; Rahi, MM	1

Trials

1 trial(s) available for antipyrine and probenecid

Article	Year
[Probenecid affects liver metabolism]. Schweizerische medizinische Wochenschrift, 1989, Dec-16, Volume: 119, Issue:50 Topics: 4-Hydroxycoumarins; Adult; Antigens; Antipyrine; Humans; Hydrocortisone; Liver; Phenprocoumon; Probenecid; Protein C	1989

Other Studies

13 other study(ies) available for antipyrine and probenecid

Article	Year
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Comparative effects of rifampin and/or probenecid on the pharmacokinetics of temazepam and nitrazepam. International journal of clinical pharmacology, therapy, and toxicology, 1990, Volume: 28, Issue:9 Topics: 17-Hydroxycorticosteroids; Adult; Antipyrine; Endoplasmic Reticulum; Humans; Hydrocortisone; Nitrazepam; Probenecid; Rifampin; Temazepam; Time Factors	1990
Enzyme induction of renal transport mechanism by rifampicin in man? Pharmacology & therapeutics, 1987, Volume: 33, Issue:1 Topics: Antipyrine; Biological Transport; Edetic Acid; Enzyme Induction; Glomerular Filtration Rate; Humans; Iodohippuric Acid; Kidney; Kidney Tubules; Probenecid; Rifampin	1987
Implications of enzyme induction in drug toxicity studies. Toxicology and applied pharmacology, 1967, Volume: 10, Issue:2 Topics: Animals; Antipyrine; Diphenhydramine; Dogs; Enzyme Induction; Female; Haplorhini; Liver; Male; Microsomes; Peptic Ulcer; Phenylbutazone; Probenecid; Rats; Tolbutamide	1967
ENHANCEMENT OF ANTIMICROBIAL ACTIVITY OF PENICILLINS AND OTHER ANTIBIOTICS IN HUMAN SERUM BY COMPETITIVE SERUM BINDING INHIBITORS. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1964, Volume: 117 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antibiotics, Antitubercular; Antipyrine; Cephalothin; Humans; Methicillin; Naphthalenes; Oxacillin; Penicillamine; Penicillin G; Penicillin V; Penicillins; Pharmacology; Probenecid; Salicylates; Staphylococcus; Sulfonamides	1964
The effect of probenecid and MK-571 on the feto-maternal transfer of saquinavir in dually perfused human term placenta. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2009, Jul-12, Volume: 37, Issue:5 Topics: Antipyrine; Biological Transport; Female; HIV Protease Inhibitors; Humans; In Vitro Techniques; Maternal-Fetal Exchange; Multidrug Resistance-Associated Proteins; Organic Anion Transporters; Perfusion; Placenta; Pregnancy; Probenecid; Propionates; Quinolines; Saquinavir; Trophoblasts	2009