antipyrine has been researched along with methotrexate in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (30.43) | 18.7374 |
| 1990's | 1 (4.35) | 18.2507 |
| 2000's | 9 (39.13) | 29.6817 |
| 2010's | 6 (26.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Artursson, P; Bergström, CA; Matsson, P; Nagahara, N; Norinder, U; Tavelin, S | 1 |
| Jolivette, LJ; Ward, KW | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Capel, ID; Dorrell, HM; Jenner, M; Williams, DC | 1 |
| Birnie, GG; Brodie, MJ; Cooke, A; Czarnecki, D; Fitzsimons, CP; Scobie, G | 1 |
| Collins, M; Lawrence, CM; Paramsothy, J; Sharif, H; Shaw, P; Strange, R | 1 |
| Cieślińska, A; Orzechowska-Juzwenko, K; Roszkowska, E; Wiela, A | 1 |
| Sendelbeck, SL; Urquhart, J | 1 |
| Rall, DP | 1 |
| Aarbakke, J; Høyem-Johansen, T; Slørdal, L | 1 |
| Bacci, G; Fabbri, A; Ferrari, S; Figus, E; Longhi, C; Marchesini, G; Marchi, E; Motta, E | 1 |
| Boguslawska-Jaworska, J; Golebiowski, W; Gorczynska, E; Hurkacz, M; Orzechowska-Juzwenko, K; Wiela-Hojenska, A | 1 |
1 trial(s) available for antipyrine and methotrexate
| Article | Year |
|---|---|
Metabolic functions of the liver during chemotherapy in children with acute lymphoblastic leukemia.
Topics: Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Antipyrine; Child; Child, Preschool; Half-Life; Humans; Liver; Liver Function Tests; Metabolic Clearance Rate; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2001 |
22 other study(ies) available for antipyrine and methotrexate
| Article | Year |
|---|---|
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Exploring the role of different drug transport routes in permeability screening.
Topics: Administration, Oral; Biological Transport; Caco-2 Cells; Cell Line; Humans; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Membranes, Artificial; Models, Biological; Molecular Conformation; Monte Carlo Method; Permeability; Pharmaceutical Preparations; Pharmacokinetics | 2005 |
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution | 2005 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Hepatic function assessed (in rats) during chemotherapy with some anti-cancer drugs.
Topics: Alkaline Phosphatase; alpha-Fetoproteins; Animals; Antipyrine; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Cyclophosphamide; Dactinomycin; Fluorouracil; gamma-Glutamyltransferase; Glutamate Dehydrogenase; Liver; Male; Methotrexate; Ornithine Carbamoyltransferase; Rats; Vincristine | 1979 |
Hepatic metabolic function in patients receiving long-term methotrexate therapy: comparison with topically treated psoriatics, patient controls and cirrhotics.
Topics: Aged; Alkaline Phosphatase; Antipyrine; Female; gamma-Glutamyltransferase; Humans; Indocyanine Green; Kinetics; Liver; Liver Cirrhosis; Liver Function Tests; Male; Methotrexate; Middle Aged; Psoriasis; Time Factors | 1985 |
The use of antipyrine clearance to measure liver damage in psoriatic patients receiving methotrexate.
Topics: Adult; Antipyrine; Biopsy; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Diseases; Liver Function Tests; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Psoriasis; Saliva | 1988 |
Metabolic efficiency of the liver in patients with breast cancer as determined by pharmacokinetics of phenazone.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Antipyrine; Biotransformation; Breast Neoplasms; Carcinoma; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Humans; Liver; Metabolic Clearance Rate; Methotrexate; Middle Aged | 1987 |
Spatial distribution of dopamine, methotrexate and antipyrine during continuous intracerebral microperfusion.
Topics: Animals; Antipyrine; Blood-Brain Barrier; Brain; Cisplatin; Dopamine; Female; Hydroxydopamines; Methotrexate; Norepinephrine; Perfusion; Rabbits; Rats | 1985 |
Conference on obstacles to the control of acute leukemia. Experimental studies of the blood-brain barrier.
Topics: Aminohippuric Acids; Antipyrine; Blood-Brain Barrier; Child; Humans; Hydrocortisone; Leukemia; Male; Mercaptopurine; Methotrexate; Perfusion; Sulfadiazine; Vincristine | 1965 |
Microsomal metabolism of antipyrine in rats treated with antineoplastic drugs.
Topics: Animals; Antineoplastic Agents; Antipyrine; Body Weight; Cyclophosphamide; Fluorouracil; Kinetics; Male; Methotrexate; Microsomes, Liver; Organ Size; Rats; Rats, Inbred Strains | 1983 |
High-dose methotrexate treatment and liver function in patients with osteosarcoma.
Topics: Adolescent; Adult; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Antipyrine; Bone Neoplasms; Cisplatin; Doxorubicin; Female; Galactose; Humans; Liver; Liver Function Tests; Male; Methotrexate; Osteosarcoma; Prospective Studies | 1994 |