Compounds > antipyrine

antipyrine and ketoconazole

antipyrine has been researched along with ketoconazole in 13 studies

Research

Studies (13)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (38.46)	18.7374
1990's	1 (7.69)	18.2507
2000's	3 (23.08)	29.6817
2010's	3 (23.08)	24.3611
2020's	1 (7.69)	2.80

Authors

Authors	Studies
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Atiba, JO; Blaschke, TF; Pershe, RA; Taylor, G	1
Bendikov, EA; Lapina, IZ; Leshchenko, VM; Petrakov, AV	1
Bates, TR; D'Mello, AP; D'Souza, MJ	1
Abernethy, DR; Blyden, GT; Greenblatt, DJ	1
Daneshmend, TK; Ene, MD; Johnson, EM; Parker, G; Richardson, MD; Roberts, CJ; Warnock, DW	1
Brennan, B; Ervine, CM; Houston, JB; Matthew, DE	1
Cho, HY; Jeon, YH; Jung, K; Kim, HS; Kim, K; Kim, S; Kwon, NH; Lee, JY; Lee, S; Seo, B; Suh, YG	1

Trials

1 trial(s) available for antipyrine and ketoconazole

Article	Year
Pharmacokinetics of ketoconazole-antipyrine interaction. Lancet (London, England), 1985, Jul-27, Volume: 2, Issue:8448 Topics: Adult; Antipyrine; Drug Interactions; Humans; Ketoconazole; Kinetics; Male	1985

Other Studies

12 other study(ies) available for antipyrine and ketoconazole

Article	Year
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Plasma antipyrine half-life can be determined from urine data. British journal of clinical pharmacology, 1987, Volume: 23, Issue:6 Topics: Adult; Aged; Antipyrine; Female; Half-Life; Humans; Interferons; Ketoconazole; Male; Middle Aged; Saliva	1987
[Detoxifying function of the liver in patients with rubromycosis during treatment with antimycotics]. Vestnik dermatologii i venerologii, 1989, Issue:4 Topics: Adult; Antifungal Agents; Antipyrine; Female; Griseofulvin; Humans; Ketoconazole; Liver; Liver Function Tests; Male; Middle Aged; Saliva; Time Factors; Tinea	1989
Ketoconazole does not impair antipyrine clearance in humans. International journal of clinical pharmacology, therapy, and toxicology, 1986, Volume: 24, Issue:5 Topics: Adult; Aged; Antipyrine; Female; Half-Life; Humans; Ketoconazole; Male; Metabolic Clearance Rate; Middle Aged	1986
Multiple dose pharmacokinetics of ketoconazole and their effects on antipyrine kinetics in man. The Journal of antimicrobial chemotherapy, 1983, Volume: 12, Issue:2 Topics: Adult; Antipyrine; Drug Interactions; Half-Life; Humans; Ketoconazole; Kinetics; Male; Metabolic Clearance Rate; Middle Aged	1983
Comparison of ketoconazole and fluconazole as cytochrome P450 inhibitors. Use of steady-state infusion approach to achieve plasma concentration-response relationships. Drug metabolism and disposition: the biological fate of chemicals, 1996, Volume: 24, Issue:2 Topics: Animals; Antifungal Agents; Antipyrine; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluconazole; Infusion Pumps; Ketoconazole; Liver; Male; Metabolic Clearance Rate; Rats; Rats, Sprague-Dawley	1996
Discovery of novel potent migrastatic Thiazolo[5,4-b]pyridines targeting Lysyl-tRNA synthetase (KRS) for treatment of Cancer metastasis. European journal of medicinal chemistry, 2021, Jun-05, Volume: 218 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Female; Humans; Lysine-tRNA Ligase; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Molecular Structure; Pyridines; Structure-Activity Relationship	2021