antipyrine has been researched along with edaravone in 769 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (3.77) | 18.7374 |
| 1990's | 37 (4.81) | 18.2507 |
| 2000's | 308 (40.05) | 29.6817 |
| 2010's | 384 (49.93) | 24.3611 |
| 2020's | 11 (1.43) | 2.80 |
| Authors | Studies |
|---|---|
| Honda, S; Kakehi, K; Ueno, T | 1 |
| Belwon, S; Dengler, HJ; Edeki, T; Funke, C; Lindecken, KD; Robertz-Vaupel, GM | 1 |
| Abul-Hajj, Y; Awni, WM; St Peter, JV | 1 |
| Edwards, DJ; Krakovsky, DJ; Rybak, MJ; Steinberg, JD; Waite, NM; Warbasse, LH | 1 |
| Advenier, C; Cordonnier, P; Naline, E; Palette, C; Pays, M | 1 |
| Khlopushina, TG; Rybina, IV; Seredenin, SB; Zherdev, VP | 1 |
| Morita, I; Murota, S; Suda, N | 1 |
| Van Bezooijen, CF; Van Geel, CA | 1 |
| Brendel, E; de Mey, C; Meineke, I | 1 |
| Ishibashi, A; Nishi, H; Sakurai, H; Watanabe, T; Yuki, S | 1 |
| Awni, WM; St Peter, JV | 1 |
| Itoh, Y; Nishi, H; Nishibori, M; Oishi, R; Saeki, K; Watanabe, T | 1 |
| Akao, E; Honda, S; Kakehi, K; Nakamura, J; Okuda, M; Suzuki, S | 1 |
| Imai, Y; Inada, M; Inui, Y; Ito, N; Kawata, S; Matsuda, Y; Miyoshi, S; Noda, S; Saitoh, R; Tamura, S | 1 |
| Houston, JB; Shaw, PN | 1 |
| Breimer, DD; Janssens, AR; Koch, CW; Spoelstra, P; Teunissen, MW; van Duijn, W; Weeda, B | 1 |
| Morita, I; Murota, S; Nishi, H; Watanabe, T | 1 |
| Browne, TR; Greenblatt, DJ; LeDuc, BW; Mikati, MA; Pylilo, RJ; Szabo, GK | 1 |
| Anzenbacher, P; Asfaw, B; Stiborová, M | 1 |
| Anzenbacher, P; Asfaw, B; Hodek, P; Leseticky, L; Stiborová, M | 1 |
| Chenery, RJ; Jennings, P; Mason, PA; Norman, SJ; Oldham, HG; Standring, P | 1 |
| Bach, D; Blevins, R; Edwards, DJ; Kerner, N; Rubenfire, M | 1 |
| Chiba, K; Ishizaki, T; Kubota, K; Nakagawa, A; Nakamura, K; Takagi, A | 1 |
| Hall, ST; Houston, JB; Shaw, PN | 1 |
| Csillag, K; Gachályi, B; Káldor, A; Kocsis, F; Nagy, B; Vas, A | 1 |
| Back, DJ; Breckenridge, AM; Howells, RE; Rivière, JH | 1 |
| Breimer, DD; Kampf, D; Roots, I; Teunissen, MW; Vermeulen, NP | 1 |
| Pilsgaard, H; Poulsen, HE | 1 |
| Bässmann, H; Böttcher, J; Schüppel, R | 1 |
| Breimer, DD; Teunissen, MW; Vinnars, E; Wahlén, A | 1 |
| Breimer, DD; Joeres, RP; Teunissen, MW; Vermeulen, NP | 1 |
| Chiba, K; Ishizaki, T; Nakagawa, A; Nakamura, K | 1 |
| Inaba, T; Kalow, W; Tang, BK; Uchino, H | 1 |
| Böhm, H; Mager, PP; Mann, G; Wilde, H | 1 |
| Blair, IA; Boobis, AR; Brodie, MJ; Davies, DS; Kahn, GC | 1 |
| Dengler, HJ; Eichelbaum, M; Sonntag, B | 1 |
| Fischer, NE; Inaba, T | 1 |
| Fu, D; O'Neill, RA | 1 |
| Ali, HA; Ali, MA; Døssing, M; el-Yazigi, A; Ernst, P; Khan, B; Raines, DA; Saour, J; Sieck, JO | 1 |
| Ali, HA; Døssing, M; el-Yazigi, A; Ernst, P; Raines, DA; Saour, J; Sieck, JO | 1 |
| Egawa, M; Watanabe, T | 1 |
| Egawa, M; Nishi, H; Watanabe, T; Yuki, S | 1 |
| Honda, S; Kakehi, K | 1 |
| Kolker, HJ; Nijmeijer, SM; Noordhoek, J; van Miert, AS; Witkamp, RF | 1 |
| Endo, T; He, N; Kumano, K; Masaki, Y; Suyama, I | 1 |
| Cosme, J; Eichelbaum, M; Engel, G; Heidemann, H; Hofmann, U | 1 |
| Koide, S; Minhaz, U; Nakazawa, H; Shohtsu, A; Tanaka, M; Tsukamoto, H; Watanabe, K | 1 |
| Janus, K; Suszycka, J | 2 |
| Sharer, JE; Wrighton, SA | 1 |
| Janus, K; Muszczynski, Z; Suszycka, J | 1 |
| Murota, S; Sato, I | 1 |
| Kawai, H; Nakai, H; Saito, KI; Suga, M; Watanabe, T; Yuki, S | 1 |
| Gorman, JJ; Pitt, JJ | 1 |
| Tanaka, N | 1 |
| Kogure, K; Mitsuka, M; Saito, KI; Watanabe, T; Yamamoto, T; Yuki, S | 1 |
| Lanchote, VL; Ping, WC; Santos, SR | 1 |
| Almar, M; González-Gallego, J; González-Sastre, M; Jorquera, F; Pozuelo, M; Sansegundo, D | 1 |
| Mizuno, A; Nakashima, M; Umemura, K | 1 |
| Hayase, S; Kakehi, K; Nakano, M; Oda, Y; Suzuki, S | 1 |
| Honda, S; Kitano, A; Taga, A; Yabusako, Y | 1 |
| Honda, S; Kuwahara, Y; Makiura, K; Suzuki, S; Yamamoto, M | 1 |
| Fu, D; Zopf, D | 1 |
| Iwai, T; Nakashima, M; Niwa, M; Uematsu, T | 1 |
| Jamieson, JC; Perreault, H; Saba, JA; Shen, X | 2 |
| Perreault, H; Shen, X | 1 |
| Bayón, JE; Ferre, I; González-Gallego, J; Jiang, SX; Mao, XZ | 1 |
| Fung, KP; Wu, J; Wu, TW; Zeng, LH | 2 |
| Suzuki, Y; Umemura, K | 1 |
| Futami, S; Maekawa, K; Morita, I; Murota, SI; Nishida, M | 1 |
| Tabrizchi, R | 1 |
| Honda, A; Honda, S; Inoue, N; Suzuki, S; Takada, K; Tanaka, R; Yashima, Y | 1 |
| Honda, S; Suzuki, S; Taga, A | 2 |
| Hopwood, JJ; Meikle, PJ; Ramsay, SL; Ranieri, E; Rozaklis, T; Whitfield, PD | 1 |
| Butler, M; Ens, WE; Jamieson, JC; Jan, DC; Kunkel, JP; Perreault, H; Saba, JA; Standing, KG | 1 |
| Tanaka, M | 1 |
| Jin, YJ; Mima, T; Park, KC; Raicu, V; Shimizu, K | 1 |
| Ikeda, T; Ikenoue, T; Kaneko, M; Sameshima, H; Xia, YX | 1 |
| Ens, W; Ethier, M; Perreault, H; Saba, JA; Standing, KG | 1 |
| Hirakata, H; Itoh, Y; Makino, K; Mishima, K; Oishi, R; Sueishi, K; Tsuruya, K | 1 |
| Naritomi, H | 1 |
| Ikeda, Y; Satoh, K; Shioda, S; Tobe, T; Yoshikawa, T | 1 |
| Harada, N; Hiroshige, S; Ninomiya, M; Shimada, M; Shiotani, S; Soejima, Y; Suehiro, T; Sugimachi, K | 1 |
| Chernousova, NIa; Gichev, IuIu; Gichev, IuP; Grek, OR; Makkosland, K; Tolokonskaia, NP; Tomilenko, TG | 1 |
| Hashiba, Y; Imai, H; Saito, N; Sasaki, T; Shimizu, T; Tosaka, M | 1 |
| Horiike, O; Ikeda, T; Shimogori, H; Yamashita, H | 1 |
| Fujimoto, S; Horike, H; Kashihara, N; Makino, H; Namikoshi, T; Sasaki, T; Satoh, M; Tokura, T | 1 |
| Enzan, H; Miyahara, Y; Okatani, Y; Wakatsuki, A | 1 |
| Ogawa, Y; Onishi, S; Ono, M; Saibara, T; Toda, K; Wakatsuki, A | 1 |
| Hayashi, T; Inamoto, S; Kitaura, Y; Mori, H; Mori, T; Okada, Y; Okuda, N; Sohmiya, K | 1 |
| Andoh, A; Araki, Y; Asano, N; Bamba, S; Fujiyama, Y; Ishizuka, I; Yokono, T; Yoshikawa, K | 1 |
| Andoh, A; Araki, Y; Fujiyama, Y | 1 |
| Ishii, H; Kameyama, K; Kumagai, N; Nakamoto, N; Saito, H; Tada, S; Tsunematsu, S | 1 |
| Maeda, H; Rajesh, KG; Sasaguri, S; Suzuki, R | 1 |
| Xu, J; Zhang, L; Zhang, W; Zhang, Y | 1 |
| Hashimoto, N; Takabatake, Y; Tsuchiya, Y; Uno, E; Wakamatsu, K; Yamazaki, N | 1 |
| Iseki, K; Morinaka, Y; Nishi, H; Watanabe, K; Watanabe, T; Yuki, S | 1 |
| Shinoda, M; Taniguchi, M; Watanabe, K | 1 |
| Amemiya, H; Asakawa, M; Fujii, H; Kono, H; Maki, A; Matsuda, M; Matsumoto, Y; Yamamoto, M | 1 |
| Gando, S; Hattori, Y; Jesmin, S; Kemmotsu, O; Matsuda, N; Sakuraya, F; Zhang, XH | 1 |
| Gyo, K; Hakuba, N; Hyodo, J; Maetani, T; Shimizu, Y; Taniguchi, M | 1 |
| Wang, LF; Zhang, HY | 1 |
| Ishii, H; Kameyama, K; Kitamura, K; Kurita, S; Nakamoto, N; Saito, H; Saito, Y; Tada, S | 1 |
| Arai, A; Honda, S; Ishida, Y; Nakanishi, H; Suzuki, S | 1 |
| Echizen, H; Oishi, K; Uchida, M; Yamaguchi, T | 1 |
| Ichikawa, K; Imamura, T; Kiguchi, S; Kobayashi, K; Kojima, M; Yamazaki, Y | 1 |
| Ichikawa, H; Imamoto, E; Isozaki, Y; Katada, K; Kokura, S; Naito, Y; Okanoue, T; Takagi, T; Tomatsuri, N; Uchiyama, K; Yoshida, N; Yoshikawa, T | 1 |
| Abe, K; Itoyama, Y; Sakurai, M; Tabayashi, K; Takahashi, G | 2 |
| Ge, QF; Peng, GP; Wei, EQ; Yu, LF | 1 |
| Furuya, Y; Hayashi, T; Nakamura, H; Nakayama, H; Ominato, M; Owada, S; Sekino, H; Uchida, K; Uzura, M | 1 |
| Abe, S; Hasegawa, T; Houchi, H; Kirima, K; Okamoto, M; Tamaki, T; Tsuchiya, K; Yoshizumi, M | 1 |
| Harada, N; Maehara, Y; Ninomiya, M; Shimada, M; Soejima, Y; Suehiro, T | 1 |
| Echizen, H; Hiraga, M; Ida, T; Kobayashi, T; Oishi, K; Uchida, MK; Yamaguchi, T | 1 |
| Okuda, T; Shimogori, H; Sugahara, K; Takemoto, T; Yamashita, H | 1 |
| Takamatsu, Y; Tanaka, M; Tobe, A; Watanabe, K; Watanabe, T | 1 |
| Nomoto, N | 1 |
| Doi, K; Fujita, T; Nakao, A; Noiri, E; Suzuki, Y | 1 |
| Li, W; Liu, LY; Wang, ML; Wei, EQ | 1 |
| Abe, K; Hayashi, T; Horiuchi, S; Kato, S; Nagano, I; Omori, N; Sato, K; Zhang, W | 1 |
| Hisatome, I; Igawa, O; Miake, J; Ogino, K; Sasaki, N; Shigemasa, C; Shimoyama, M; Tajima, F; Yamawaki, M | 1 |
| Igarashi, H; Katayama, Y | 1 |
| Abe, K | 4 |
| Arihiro, S; Fujii, K; Ibayashi, S; Iida, M; Kamouchi, M; Nakane, H; Okada, Y; Toyoda, K | 1 |
| Hosoi, T; Nomura, Y; Okuma, Y; Qi, X | 1 |
| Chang, B; Iguchi, T; Inoue, M; Muroya, O; Nakatani, T; Nishikawa, M; Sato, EF | 1 |
| Ikebe, K; Irie, H; Kato, T; Oniki, Y; Takagi, K; Tsuchida, T | 1 |
| Ishida, A; Nakajima, W; Takada, G; Yasuoka, N | 1 |
| Anzai, K; Furuse, M; Ikota, N; Matsuyama, A; Moritake, T; Tsuboi, K; Yoshida, A | 1 |
| Arai, H; Fukuda, M; Hida, S; Hokamaki, J; Kawano, H; Nagayoshi, Y; Nakamura, Y; Ogawa, H; Sakamoto, T; Shimomura, H; Tsujita, K; Yamashita, T; Yoshimura, M | 1 |
| Chen, Z; Chu, LS; Mei, RH; Wei, EQ; Xu, HM; Yu, GL; Zhang, Q; Zhang, SH; Zhang, WP; Zhao, MH | 1 |
| Hasegawa, T; Ishikawa, M; Kakui, N; Nakajima, H; Ohkuma, K | 1 |
| Horiike, O; Shimogori, H; Yamashita, H | 1 |
| Chayama, K; Goto, C; Hara, K; Higashi, Y; Jitsuiki, D; Kimura, M; Nakagawa, K; Noma, K; Oshima, T; Yoshizumi, M | 1 |
| Endo, H; Fukuda, T; Inoue, T; Kobayashi, M; Ogasawara, K; Ogawa, A | 1 |
| Horiuchi, M; Ishikawa, T; Iwai, M; Iwasaki, Y; Kuroda, S; Shichinohe, H; Yasuda, H | 1 |
| Ikeda, T; Ikenoue, T; Itoh, O; Noor, JI; Ueda, Y; Yokoyama, H | 1 |
| Shinohara, Y | 1 |
| Kaibori, M; Kamiyama, Y; Kwon, AH; Okumura, T; Qiu, Z; Tsuji, K; Yoshida, H | 1 |
| Horikawa, S; Ito, K; Ozasa, H | 1 |
| Fukumoto, SY; Fumoto, N; Inoue, A; Kumon, Y; Oda, S; Ohnishi, T; Ohue, S; Watanabe, H | 1 |
| Banno, M; Jin, S; Kato, H; Kawanokuchi, J; Kuno, R; Mizuno, T; Suzumura, A; Takeuchi, H; Wang, J; Zhang, G | 1 |
| Nishiyama, T; Ogawa, M | 1 |
| Namiki, Y; Sasaki, K; Sato, N; Tada, N; Yoshida, H | 1 |
| Akamatsu, H; Mikawa, K; Nishina, K; Niwa, Y; Obara, H | 1 |
| Fushimi, H | 1 |
| Wei, EQ; Zhang, LH | 1 |
| Aghazadeh-Habashi, A; Anastassiades, T; Carran, J; Jamali, F | 1 |
| Hikoso, S; Hori, M; Kashiwase, K; Kogo, M; Matsumura, Y; Nakai, A; Nishida, K; Otsu, K; Takeda, T; Taniike, M; Tsujimoto, I; Watanabe, T; Yamaguchi, O | 1 |
| Jesmin, S; Kakehata, H; Matsumoto, M; Otani, H; Sakuma, I; Togashi, H; Yamaguchi, T; Yoshioka, M | 1 |
| Ashwood, T; Green, AR | 1 |
| Krokhin, O; Lattová, E; Perreault, H; Snovida, S | 1 |
| Endo, Y; Fujimiya, M; Hanasawa, K; Mori, T; Shimizu, T; Tabata, T; Tani, T; Yamamoto, H | 1 |
| Foëx, BA | 1 |
| Thorburn, K | 1 |
| Iwashita, Y; Kuno, S; Nakamura, T; Ohta, S; Takada, H | 1 |
| Amemiya, S; Inaba, T; Kamiya, T; Katayama, Y; Kato, K; Nito, C; Shimazaki, K; Ueda, M | 1 |
| Nakai, A; Nakai, M; Okuda, N; Takeshita, T; Taniuchi, Y; Yokota, A | 1 |
| Hashikura, Y; Ikeda, U; Ise, H; Ishida, A; Miyagawa, S; Nakayama, J; Suzuki, F; Takahashi, M | 1 |
| Ali, AE; El Zaher Mostafa, MA; Masoud, MS; Mohamed, RH | 1 |
| Horinaka, S; Matsuoka, H; Yagi, H | 1 |
| Hong, KW; Lee, JH; Lee, WS; Park, SY | 1 |
| Harada, T; Kano, T; Katayama, Y | 1 |
| Kawai, H; Maeda, K; Murata, Y; Tahara, M; Tatsumi, M; Yasuda, H | 1 |
| Jiang, A; Kraus, RL; Lariosa-Willingham, K; Pasieczny, R; Trauger, JW; Turner, MS | 1 |
| Fukuchi, T; Hamamoto, M; Katayama, Y; Kobayashi, S; Komaba, Y; Kominami, S; Mishina, M; Mizunari, T; Tanaka, N; Teramoto, A | 1 |
| Fujita, M; Furukawa, H; Jin, MB; Nakayama, M; Shimamura, T; Suzuki, T; Tahara, M; Taniguchi, M; Todo, S | 1 |
| Kaneko, K; Someya, T; Yamada, T; Yamashiro, Y | 1 |
| Handa, O; Higashihara, H; Ishikawa, T; Kokura, S; Naito, Y; Nakabe, N; Sakamoto, N; Takagi, T; Yoshida, N; Yoshikawa, T | 1 |
| Hattori, M; Kishimoto, C; Nimata, M; Okabe, TA; Shioji, K; Yuan, Z | 1 |
| Hashizume, K; Mori, A; Shimizu, H; Ueda, T; Yozu, R | 1 |
| Komine-Kobayashi, M; Liu, M; Mizuno, Y; Tanaka, R; Urabe, T; Zhang, N | 1 |
| Endo, H; Fukuda, T; Inoue, T; Kobayashi, M; Ogasawara, K; Ogawa, A; Terasaki, K; Yamadate, K; Yoshida, K | 1 |
| Harada, M; Itabe, H; Kitazato, KT; Matsuzaki, K; Nagahiro, S; Suzue, A; Uno, M | 1 |
| Hashimoto, M; Mikuriya, T; Okuda, T; Shimogori, H; Sugahara, K; Takemoto, T; Takeno, K; Tanaka, K; Yamashita, H | 1 |
| Aoo, N; Egashira, N; Fujiwara, M; Ikeda, T; Ikenoue, T; Iwasaki, K; Mishima, K; Noor, JI; Ohta, S | 1 |
| Hanai, T; Levin, RM; Matsumoto, S; Shimizu, N; Sugiyama, T; Uemura, H; Yoshioka, N | 1 |
| Ikeda, T; Ikenoue, T; Noor, JI; Ueda, Y | 2 |
| Mei, Q; Wang, H; Wang, Q; Yang, X; Zhao, Y | 1 |
| Hirose, N; Maeda, H; Rao, P; Sasaguri, S; Yamamoto, M; Yutong, X | 1 |
| Fujii, T; Hasegawa, M; Inoue, M; Jin, CH; Kaneko, K; Maehara, Y; Onimaru, M; Onohara, T; Sueishi, K; Yonemitsu, Y | 1 |
| Bashar, AH; Ikeda, Y; Kazui, T; Ohkura, K; Suzuki, K; Suzuki, T; Terada, H; Umemura, K; Washiyama, N; Yamashita, K; Yasuike, J | 1 |
| Anniko, M; Takumida, M | 1 |
| Hashimoto, Y; Hirano, T; Kugimiya, F; Uchino, M; Ueda, A; Yonemura, K | 1 |
| Doi, M; Ikeda, Y; Ikemoto, N; Kobayashi, S; Matsuzaki, M; Mochizuki, M; Noma, T; Oda, T; Ohkusa, T; Okuda, S; Tateishi, H; Tokuhisa, T; Yamamoto, T; Yano, M | 1 |
| Fujikawa, T; Mishima, S; Morozumi, J; Noda, M; Ohta, S; Sasaki, H; Yukioka, T | 1 |
| Arii, K; Hashimoto, K; Ikeda, Y; Kumon, Y; Suehiro, T | 2 |
| Araki, Y; Hattori, T; Sugihara, H | 1 |
| Akamatsu, H; Reyes, YA; Shimoyama, T; Sunamori, M | 1 |
| Hayakawa, Y; Masaoka, N; Nagaishi, M; Nakajima, Y; Sakata, H; Watanabe, M; Yamamoto, T | 1 |
| Aburakawa, Y; Aizawa, H; Enomoto, H; Fujiwara, K; Hasebe, N; Katayama, T; Kikuchi, K; Kimura, T; Koyama, S; Kuroda, K; Makita, Y; Maruyama, J; Nakamura, M; Nakatani-Enomoto, S; Sumitomo, K; Suzuki, Y; Yahara, O | 1 |
| Abe, T; Itoh, Y; Ohira, M; Suzuki, N; Takaoka, R; Tanahashi, N | 1 |
| H S, AK; Patel, RJ; Saini, AK; Sharma, SS | 1 |
| Fukumoto, Y; Ikeda, R; Kariyazono, H; Nakamura, K; Onimaru, S; Sakata, R; Ueno, T; Yabuki, A; Yamada, K | 1 |
| Guo, P; Ishizawa, M; Kohno, M; Miyatake, A; Mizushige, K; Murakami, K; Namba, T; Noma, T; Ohmori, K; Tsuji, T | 1 |
| Aizawa, Y; Kodama, M; Ma, M; Tachikawa, H; Watanabe, K; Wen, J; Yamaguchi, K | 1 |
| Kitagawa, Y | 1 |
| Fujioka, S; Hashimoto, Y; Hirano, T; Inatomi, Y; Takita, T; Uchino, M; Yonehara, T | 1 |
| Ge, QF; Hu, X; Lu, YB; Wei, EQ; Zhang, L | 1 |
| Isbir, S; Koray, AK; Tekeli, A | 1 |
| Giddings, JC; Kashiwagi, S; Oda, E; Shoge, M; Suematsu, M; Yamamoto, J; Yamamoto, Y; Yamashita, T | 1 |
| Uchiyama, S | 1 |
| Connor, HD; Fujii, H; Kono, H; Maki, A; Mason, RP; Rusyn, I; Woods, CG | 1 |
| Ago, Y; Baba, A; Ishihara, K; Itoh, S; Kawasaki, T; Matsuda, T; Nakamura, S | 1 |
| Fukuda, M; Hokamaki, J; Kaikita, K; Kawano, H; Nagayoshi, Y; Nakamura, Y; Ogawa, H; Sakamoto, T; Shimomura, H; Tsujita, K; Yamashita, T; Yoshimura, M | 1 |
| Akishita, M; Eto, M; Hasegawa, H; Kozaki, K; Nagai, K; Toba, K; Xi, H; Yu, W | 1 |
| Fukatsu-Sasaki, K; Furutani, N; Namiki, Y; Tada, N; Yanai, H; Yoshida, H | 1 |
| Kitahara, S; Masuda, Y; Murata, Y; Tanabe, T | 1 |
| Abumiya, T; Ieko, M; Iwasaki, Y; Kikuchi, S; Kuroda, S; Niiya, Y; Sato, T; Shichinohe, H; Takeuchi, M; Yamagishi, S | 1 |
| Ding, XS; Wang, W; Wu, J; Wu, T | 1 |
| Shima, K | 1 |
| Akao, T; Arakawa, K; Kobayashi, K; Konno, K; Matsumoto, K; Morishita, Y; Muraoka, M; Takeyoshi, I; Totsuka, O | 1 |
| Carunchio, I; Pieri, M; Zona, C | 1 |
| Li, JC; Li, M; Song, Y; Wei, EQ | 1 |
| Kishimoto, C; Kita, T; Murayama, T; Okabe, TA; Shimada, K; Yokode, M | 1 |
| Imai, K; Izumoto, H; Kunieda, T; Mori, T; Takabatake, N; Watanabe, M | 1 |
| Hasegawa, K; Hirai, K; Kanai-Ochiai, R; Morimoto, M; Nakano-Okuda, Y; Sugimoto, T | 1 |
| Funao, K; Hayama, T; Kawahito, Y; Matsuyama, M; Nakatani, T; Sano, H; Sugimura, K; Takemoto, Y; Tsuchida, K; Yoshimura, R | 1 |
| Kimata, A; Miyata, N; Nakagawa, H; Ohyama, R; Suzuki, T | 1 |
| Blomgren, K; Culmsee, C; Eriksson, PS; Hagberg, H; Huang, Z; Kroemer, G; Nilsson, M; Plesnila, N; Qiu, L; Vahsen, N; Wang, X; Xu, F; Zhu, C | 1 |
| Arai, M; Bao, N; Chen, XH; Fujiwara, H; Kobayashi, H; Maruyama, R; Minatoguchi, S; Misao, Y; Onogi, H; Takemura, G; Uno, Y; Yamaki, T; Yasuda, S | 1 |
| Koizumi, T; Sakaki, S; Shimazaki, S; Tanaka, H | 1 |
| Doi, K; Horiuchi, T; Sasaki, H; Tamagawa, K; Tanaka, K; Taniguchi, M; Uchinami, M; Yoshida, M | 1 |
| Doi, M; Fukada, Y; Hayashi, M; Murakami, T; Nakashima, K; Nakayasu, H; Suzuki, T; Takeuchi, Y | 1 |
| Aizawa, S; Kodama, S; Taga, A; Yamamoto, A; Yamashita, T | 1 |
| Ikeda, Y | 1 |
| Mikuriya, T; Shimogori, H; Takemoto, T; Yamashita, H | 1 |
| Chen, Z; Ding, Q; Wei, EQ; Zhang, WP; Zhang, YJ | 1 |
| Aruga, T; Dohi, K; Mihara, Y; Miyake, Y; Nakamachi, T; Nakamura, S; Ohtaki, H; Satoh, K; Shioda, S; Yoshikawa, T | 1 |
| Aruga, T; Dohi, K; Hiratsuka, K; Nakamachi, T; Nakamura, S; Ohtaki, H; Satoh, K; Shioda, S; Yofu, S; Yoshikawa, T | 1 |
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| Fukuchi, T; Katayama, Y; Kobayashi, S; Komaba, Y; Kominami, S; Mishina, M; Mizunari, T; Teramoto, A | 1 |
| Fujita, M; Harada, E; Ikegame, S; Inoshima, I; Mizuta, Y; Nakanishi, Y; Ouchi, H; Watanabe, K; Ye, Q; Yoshimi, M | 1 |
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| Abe, T; Anan, M; Fujiki, M; Kamida, T; Kobayashi, H; Ooba, H | 1 |
| Bando, M; Enomoto, M; Gejyo, F; Ohno, S; Soda, M; Sugiyama, Y; Suzuki, E; Tajima, S; Takada, T; Yamasawa, H | 1 |
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| Akamatsu, Y; Fukumori, T; Miyagi, S; Nakamura, A; Satomi, S; Sekiguchi, S | 1 |
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| Chen, D; Chen, Y; Gu, H; Qiu, W; Zheng, L; Zhou, J | 1 |
| Li, Y; Liu, XW; Lu, HG; Shen, BZ; Xu, JZ; Xu, WH; Zhang, T | 1 |
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| Daoud, GA; Endo, T; Goto, T; Hussein, MH; Ito, T; Kakita, H; Kato, I; Kato, S; Kato, T; Mizuno, K; Nakajima, Y; Nobata, M; Sugiura, T; Suzuki, S; Togari, H | 1 |
| Kobayashi, S; Saito, I; Shinohara, Y; Uchiyama, S | 1 |
| Chen, G; Zhang, J; Zhou, F | 1 |
| Kazuyama, E; Kinoshita, Y; Saito, M; Satoh, I; Satoh, K; Shimizu, S; Tamamura, M | 1 |
| Abe, K; Fukushima, T; Goto, K; Ikegami, S; Ohta, Y; Ota, T; Takamatsu, K; Takeda, I | 1 |
| Aoki, T; Hashimoto, N; Ishibashi, R; Kataoka, H; Nishimura, M; Nozaki, K | 1 |
| Hashizume, Y; Hayashi, M; Iizuka, T; Kashiwagi, A; Katayama, Y; Kawai, H; Maeda, K; Sanada, M | 1 |
| Hattori, N; Miyamoto, N; Tanaka, R; Ueno, Y; Urabe, T; Zhang, N | 1 |
| Inada, T; Jomura, S; Kubo, K; Miyamoto, E; Nakao, S; Sakamoto, S; Shingu, K; Tomimoto, H; Xu, Y | 1 |
| Maekawa, H; Masuda, Y; Matsunobu, T; Onozato, K; Shiotani, A; Tanabe, T; Tsuda, H | 1 |
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| Imai, K; Kawamoto, T; Miyamoto, Y; Neishi, Y; Okura, H; Toyota, E; Yoshida, K | 1 |
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| Ino, T; Kamijo, T; Okamoto, M; Sano, H | 1 |
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| Masaoka, N; Nagaishi, M; Nakajima, Y; Watanabe, M; Yamamoto, T | 1 |
| Iida, H; Nagasaka, T; Shindo, K; Shiozawa, Z | 1 |
| Cañuelo, A; Cárdenas, S; Javier Oliver, F; Martínez-Lara, E; Martínez-Romero, R; Siles, E | 1 |
| Maeno, T; Mano, T; Takenaka, H; Tano, R | 1 |
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| Iwama, T; Yamakawa, H; Yoshimura, S | 1 |
| Aldini, G; Benfatto, MC; Bettinelli, I; Carini, M; Regazzoni, L; Vistoli, G | 1 |
| Arimura, N; Arimura, S; Biswas, KK; Hashiguchi, T; Ito, T; Iwata, M; Kawahara, K; Kikuchi, K; Kuramoto, T; Maenosono, R; Maruyama, I; Matsuda, F; Meng, X; Mera, K; Miura, N; Morimoto, Y; Nakayama, K; Nawa, Y; Ohno, Y; Oyama, Y; Sameshima, H; Shigemori, M; Shrestha, B; Tajima, Y; Takenouchi, K; Tancharoen, S; Uchikado, H; Yoshida, Y | 1 |
| Hashimoto, S; Imano, M; Ito, H; Itoh, T; Nishida, S; Satou, T; Tsubaki, M | 1 |
| Ding, XS; Gao, Y; Kuai, F; Wang, W; Xu, S; Zuo, QL | 1 |
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| Kamibayashi, T; Mashimo, T; Shibuta, S; Varathan, S | 1 |
| Chitose, T; Fukuda, M; Kaikita, K; Nagata, T; Nagayoshi, Y; Nakamura, Y; Nako, H; Ogawa, H; Ogura, Y; Ohba, K; Shimomura, H; Soejima, H; Sugiyama, S; Tsujita, K; Yamada, Y; Yamaguchi, M; Yamashita, T | 1 |
| Deng, XL; Li, GQ; Wang, HP | 2 |
| Imaizumi, T; Ishikawa, A; Matsumiya, T; Metoki, N; Ohyama, C; Ota, K; Satoh, K; Tanji, K; Yoshida, H | 1 |
| Fujisawa, A; Kashiba, M; Tak, NW; Takahashi, C; Tanaka, M; Watanabe, K; Yamamoto, Y; Yanagisawa, M | 1 |
| Cai, ZY; Deng, XM; Hou, J; Hu, JY; Liu, SQ; Mao, YF; Ni, X; Yang, T; Zhu, XY | 1 |
| Cao, TW; Shen, L; Shi, M; Sun, ZD; Zhu, HC | 1 |
| Enomoto, A; Hosoi, Y; Igaki, H; Katsumura, Y; Matsumoto, Y; Miyagawa, K; Morita, A; Nakagawa, K; Sasano, N; Shiraishi, K | 1 |
| Hanai, T; Matsumoto, S; Shimizu, N; Sugimoto, K; Uemura, H | 1 |
| Katayama, M; Shimizu, H; Unno, Y | 1 |
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| Li, GQ; Wang, HP | 1 |
| Adachi, S; Arai, T; Endo, N; Miyoshi, T; Mori, H; Nishinaka, Y; Yamashita, K | 1 |
| Chen, HH; Cui, JZ; Gao, JL; Guo, X; Tian, YX; Zhao, YN | 1 |
| El Bahh, B; Richard, MJ; Saleh, TM; Zidichouski, JA | 1 |
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| Kadokami, T; Maeda, T; Makino, N; Oyama, J; Satoh, S; Suematsu, N; Sugano, M | 1 |
| Fukuda, M; Maeda, M; Motomura, T; Mukai, T; Sano, Y; Yamamoto, F | 1 |
| Arimura, S; Hashiguchi, T; Kawahara, K; Kikuchi, K; Kuramoto, T; Maenosono, R; Maruyama, I; Matsuda, F; Mera, K; Miura, N; Miyagi, N; Morimoto, Y; Ohno, Y; Oyama, Y; Shigemori, M; Shrestha, B; Tada, K; Takenouchi, K; Tancharoen, S; Uchikado, H; Yoshida, Y; Yoshinaga, N | 1 |
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| Abe, K; Deguchi, K; Kawai, H; Liu, N; Lukic-Panin, V; Matsuura, T; Shang, J; Tian, F; Yamashita, T; Zhang, X | 1 |
| Li, Y; Xia, AZ; Xing, SH | 1 |
| Hiyama, E; Murakami, Y; Nagatani, S; Sudo, T; Sueda, T; Uemura, K | 1 |
| Higashi, Y; Kondo, H; Metoki, N; Moriwaki, H; Naritomi, H; Nishimura, H; Oda, T; Oe, H; Saito, K; Tanahashi, N; Tanaka, K; Terayama, Y; Yamamoto, Y; Yuasa, H | 1 |
| Qian, X; Sun, H; Yang, L; Zhi, Q | 1 |
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| Munakata, A; Ohkuma, H; Shimamura, N | 1 |
| Fu, H; Hata, K; Katsumura, Y; Lin, M; Muroya, Y; Nakagawa, H; Yamashita, S | 1 |
| Iwashita, Y; Kakinoki, R; Nakamura, T; Noguchi, T; Ohta, S | 1 |
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| Hayakari, R; Imaizumi, T; Ishikawa, A; Itoh, K; Kosaka, K; Matsumiya, T; Metoki, N; Mimura, J; Ota, K; Satoh, K; Tanji, K; Yoshida, H | 1 |
| Chen, Y; Jiao, L; Li, Z; Liu, H; Xu, S; Zhang, J | 1 |
| Harada, N; Kondo, K; Kuroki, T; Nagao, T; Nemoto, M; Nomoto, J | 1 |
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| Daoud, GA; Fukuda, S; Goto, T; Hashimoto, T; Hussein, MH; Ito, T; Kakita, H; Kato, I; Kato, S; Mizuno, H; Suzuki, S; Togari, H; Yamaguchi, S | 1 |
| Baba, H; Hashizume, M; Kuwashiro, T; Lee, S; Nagata, H; Nanishi, E; Sugimori, H | 1 |
| Jiang, CM; Li, GQ; Wang, HP | 1 |
| Nakase, T; Suzuki, A; Yoshioka, S | 1 |
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| Fukuda, A; Itoh, H; Maehara, Y; Onohara, T; Saito, S; Takai, M; Takano, T; Yonemitsu, Y | 1 |
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| Fujii, Y; Morishima, T; Nosaka, N; Saito, Y; Tsuge, M; Tsukahara, H; Yamada, M; Yamashita, N; Yashiro, M | 1 |
| Bezbaruah, BK; Gurjar, SS; Jangra, A; Mohan, P; Sriram, CS | 1 |
| Chijiiwa, M; Elmér, E; Hara, N; Inazu, M; Ishida, Y; Karlsson, M; Kuroda, M; Ogiwara, Y; Sjovall, F; Uchino, H; Yara, M | 1 |
| Guo, B; Lee, SM; Sun, Y; Wang, L; Wang, Y; Yu, P; Zhang, G; Zhang, Z; Zhou, X; Zhu, L | 1 |
| Cao, B; Chai, C; Zhao, S | 1 |
| Chen, X; Zheng, J | 1 |
| Diez-Cecilia, E; Lavery, CB; MacLean, MA; Reed, MA; Stradiotto, M; Wang, Y; Weaver, DF | 1 |
| Chen, X; Chen, Y; Lu, Z; Wang, S; Xu, W | 1 |
| Apaydin, M; Erbas, O; Taskiran, D | 1 |
| Peng, CG; Song, YY; Ye, XB | 1 |
| Borah, P; Dwivedi, S; Gurjar, SS; Hussain, MI; Jangra, A; Lahkar, M; Sriram, CS | 1 |
| Kou, Y; Tan, X; Wang, H; Xie, B; Zhang, J; Zhang, M | 1 |
| Hara, H; Masuda, T; Nakamura, S; Shimazawa, M; Takata, S; Tsuruma, K | 1 |
| Cai, SH; Chen, JL; Deng, J; Duan, WJ; He, RR; Kurihara, H; Li, YF; Liu, FL; Tsoi, B; Wang, Q; Wu, YP; Yuan, WL | 1 |
| Arslanoğlu, S; Börekci, H; Ciğer, E; Önal, K; Turan, M | 1 |
| Han, J; Huang, C; Liao, G; Zhang, G; Zou, B | 1 |
| Hu, H; Liu, Q; Sun, Xo; Tan, W; Tian, F; Zhang, H | 1 |
| Allaka, TR; Anantaraju, HS; Anireddy, JS; Balasubramanian, S; Dharmarajan, S; Gandamalla, D; Perumal, Y; Polkam, N; Ramaswamy, VR; Rayam, P; Yellu, NR | 1 |
| Gu, TX; Li-Ling, J; Qi, X; Sun, XJ; Wang, C; Wang, XB; Zhang, GW | 1 |
| Luan, XH; Pu, JH; Wang, QC; Zhao, X | 1 |
| Chen, Z; Fan, H; Tang, JZ; Tang, X; Wan, Q; Wu, X; Xie, X; Zhang, W | 1 |
| Cao, J; Liu, N; Ma, L; Wang, P; Wang, Y; Zhang, H; Zhou, X | 1 |
| Hu, Y; Liu, X; Luo, Q; Zhao, Y; Zheng, Y; Zou, L | 1 |
| Houkin, K; Kazumata, K; Kuroda, S; Nakayama, N; Uchino, H | 1 |
| Chen, J; Ding, WS; Ding, XS; Liu, XF; Shen, HC; Shen, LH; Sheng, YF; Ye, M | 1 |
| Li, J; Liu, S; Shi, L; Song, F; Su, R; Wan, D; Yang, H; Zhuang, X | 1 |
| Kiernan, MC; Noto, Y; Shibuya, K; Vucic, S | 1 |
| Yagita, Y | 1 |
| Liu, C; Sun, Z; Zhu, Y | 1 |
| Chang, W; Gong, J; Ji, L; Li, X; Liu, Y; Qin, L; Wei, S; Zhang, Y | 1 |
| Gao, M; Ge, GZ; Ji, XC; Sun, YL; Wang, QQ; Xu, RX; Yang, Y; Zhang, GZ; Zhang, HT; Zhang, Y | 1 |
| Chen, MH; Lei, LY; Li, N; Qin, T; Shi, FR; Xie, L | 1 |
| Baba, A; Itoh, Y; Kawakami, Y; Murashima, YL; Saito, K | 1 |
| Nakano, H; Yamada, M; Yanase, D | 1 |
| Inahashi, Y; Matsumoto, A; Nakashima, T; Ōmura, S; Shiomi, K; Takahashi, Y; Také, A | 1 |
| Chen, W; Wang, M; Wang, Y; Yan, Y; Zeng, J; Zhang, C; Zhang, J; Zhang, T; Zhao, H; Zhou, W | 1 |
| Ahmed, S; Dwivedi, D; Jangra, A; Kushwah, P; Kwatra, M; Lahkar, M; Pant, R; Saroha, B; Singh, T | 1 |
| Feng, ZC; Li, Z; Ma, QQ; Xu, FD; Yan, Y; Zhang, XY; Zhou, WQ | 1 |
| Arai, K; Fujiwara, N; Lee, BJ; Lo, EH; Mandeville, ET; Pham, LD; Som, AT | 1 |
| Altun, İK; Alver, A; Arslan, FC; Gedikli, Ö; İnce, İ; Özkorumak, E; Tiryaki, A; Yıldırım, M | 1 |
| Morita, M; Naito, Y; Niki, E; Yoshikawa, T | 1 |
| Garg, S; Kathawala, K; Parikh, A; Tan, CC; Zhou, XF | 2 |
| Ge, X; Li, W; Li, X; Liang, X; Lu, F; Qin, L; Yao, Y; Yu, Q; Zhang, J; Zhao, D | 1 |
| Awano, H; Matsuda, H; Tanahashi, N; Yamaguchi, T | 2 |
| Abe, K; Yamashita, T | 1 |
| Bai, X; Chen, A; Li, J; Liu, W; Sun, Q; Wang, H; Zhang, C | 1 |
| Catalão, CHR; da Silva Lopes, L; Garcia, CAB; Júnior, IM; Machado, HR; Peixoto-Santos, JE; Romeiro, TH; Santos, MV | 1 |
| Jiang, L; Ju, T; Li, Y; Lin, J; Liu, T; Sun, L; Wang, X; Xiao, L; Xu, Y; Yang, M; Zhang, L; Zhao, T; Zhou, S | 1 |
| Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Tan, Z; Xu, R; Yang, X; Zheng, Y | 1 |
| Hara, H; Masuda, T; Shimazawa, M | 1 |
| Gupta, YK; Reeta, KH; Singh, D | 1 |
| Kang, SS; Wu, R; Zhang, DY; Zhang, ZW | 1 |
| Dimitriadis, F; Hikita, K; Honda, M; Saito, M; Shimizu, S; Shiomi, T; Sofikitis, N; Takenaka, A; Tomita, S; Tsounapi, P | 1 |
| Huang, L; Qiu, P; Ren, J; Wang, J; Wang, Z; Wu, J; Wu, S; Xu, Q; Yao, S; Yun, D; Zhou, P | 1 |
| Gil, C; Martinez, A; Palomo Ruiz, MD; Perez, DI | 1 |
| Hu, XL; Liu, X; Shan, MT; Shao, F | 1 |
| Li, Y; Liu, H; Wei, J; Zeng, W | 1 |
| Cai, Y; Gao, X; Jin, Q; Ju, S; Li, C; Li, S; Liu, H; Lu, C; Qian, J; Zhang, J; Zhou, X | 1 |
| Sawada, H | 1 |
| Hardiman, O; van den Berg, LH | 1 |
| An, W; Bi, A; Chen, R; Dong, X; Han, X; Luo, L; Luo, Z; Tang, H; Yang, S; Yang, W; Zhang, Z | 1 |
| Akaiwa, K; Azuchi, Y; Guo, X; Harada, C; Harada, T; Kimura, A; Mitamura, Y; Namekata, K | 1 |
| Du, JM; Du, Y; Guo, YY; Li, T; Li, TT; Liu, J; Ma, ZL; Wang, HY; Yao, L; Zhang, GL; Zhang, L | 1 |
| Ando, S; Funato, M; Hara, H; Inagaki, S; Kameyama, T; Kaneko, H; Kawase, C; Ohuchi, K; Seki, J; Shimazawa, M; Tsuruma, K | 1 |
| Akimoto, M; Palumbo, J; Sakata, T; Takei, K; Watanabe, K; Yuki, S | 1 |
| Maragakis, NJ | 1 |
| Liu, S; Palumbo, J; Takahashi, F; Takei, K; Tsuda, K | 1 |
| Palumbo, J; Takahashi, F; Takei, K; Tsuda, K | 2 |
| Ishizaki, K; Kalin, A; Kim, A; Medina-Paraiso, E; Saita, T; Wasaki, M; Zhang, Y | 1 |
| Akimoto, M; Nakamura, K | 1 |
| Mora, JS | 1 |
| Tao, QQ; Wu, ZY | 1 |
| Hu, HZ; Hu, YQ; Lin, H; Liu, JX; Ma, X; Pu, FF; Shao, ZW; Wang, BC; Zhao, L | 1 |
| Akiyama, G; Azuchi, Y; Guo, X; Harada, C; Harada, T; Kimura, A; Namekata, K; Noro, T | 1 |
| Al-Chalabi, A; Andersen, PM; Chandran, S; Chio, A; Corcia, P; Couratier, P; Danielsson, O; de Carvalho, M; Desnuelle, C; Grehl, T; Grosskreutz, J; Hardiman, O; Holmøy, T; Ingre, C; Karlsborg, M; Kleveland, G; Koch, JC; Koritnik, B; KuzmaKozakiewicz, M; Laaksovirta, H; Ludolph, A; McDermott, C; Meyer, T; Mitre Ropero, B; Mora Pardina, J; Nygren, I; Petri, S; Povedano Panades, M; Salachas, F; Shaw, P; Silani, V; Staaf, G; Svenstrup, K; Talbot, K; Tysnes, OB; Van Damme, P; van den Berg, LH; van der Kooi, A; Weber, M; Weydt, P; Wolf, J | 1 |
| Chen, JJ; Fu, JL; Huang, JK; Wang, HM; Xiang, JY; Zhang, T; Zhao, YW | 1 |
| Guo, Y; Hao, C; He, Y; Lan, Y; Li, X; Liu, T; Liu, Y; Luo, H; Ren, S; Song, N; Yu, H; Zhang, L | 1 |
| Feng, L; Liu, L; Shen, Y; Sun, Y; Wu, X; Xu, F; Xu, Q; Zhang, X | 1 |
| Han, F; Tan, J; Xu, YP | 1 |
| Scott, A | 1 |
| Rothstein, JD | 1 |
| Chen, G; Lai, R; Liang, Z; Su, X; Wang, X | 1 |
| Dong, Y; Liu, Z; Lv, P; Qi, Q; Teng, Z; Xiao, Y; Zhang, D | 1 |
| Baghel, M; Rajput, SJ | 1 |
| Harada, Y; Hosokawa, K; Ito, T; Kamikokuryo, C; Kawahara, KI; Kikuchi, H; Kikuchi, K; Kiyama, R; Maruyama, I; Miura, N; Morimoto-Yamashita, Y; Morioka, M; Nagasato, T; Nakanishi, K; Otsuka, S; Sakakima, H; Sameshima, H; Setoyama, K; Shrestha, B; Tanaka, E; Tancharoen, S; Terashi, T; Ueda, K; Yamamoto, M | 1 |
| Inoue, K; Kashiwagi, M; Matsuda, T; Murata, S; Nakamura, M; Nomura, S; Oba, C; Ogino, M; Okasora, K; Shirasu, A; Tamai, H; Tanabe, T | 1 |
| Baba, H; Furutani, K; Ishii, H; Kamiya, Y; Kohno, T; Matsuhashi, M; Petrenko, AB; Sasaki, M; Satoh, Y; Tobita, T | 1 |
| Hussar, DA | 1 |
| Simmons, Z; Yeo, CJJ | 1 |
| Arai, K; Hamanaka, G; Liang, AC; Lo, EH; Lok, J; Maki, T; Miyamoto, N; Ohtomo, R; Pham, LD; Takase, H | 1 |
| Horiguchi, T; Miwa, T; Nagashima, H; Nakagawa, Y; Tomio, R; Yoshida, K | 1 |
| Beecher, L; Chen, F; Fu, H; Wang, L; Wang, W; Wang, Y; Zheng, F | 1 |
| Fukue, C; Hamano, S; Horinouchi, Y; Ikeda, Y; Kagawa, Y; Kangawa, Y; Miyamoto, L; Morimoto, Y; Tamaki, T; Tsuchiya, K; Tsuda, K; Xu, W | 1 |
| Cheng, Y; Guan, S; Hu, M; Huang, W; Li, Q; Mo, J; Ou, Z; Wang, J; Yang, J; Zhang, ZJ | 1 |
| Li, GP; Li, L; Liu, Q; Wang, ZZ; Xiao, W; Xu, ZL; Yang, H; Zhou, J; Zong, SB | 1 |
| El-Shafeey, M; Hassan, MA; Mohy Eldin, MS; Omer, AM; Šoltés, L; Tamer, TM; Valachová, K | 1 |
| Hattori, N; Kamo, H; Miyamoto, N; Ogawa, T; Shimo, Y; Tanaka, R; Ueno, Y; Yamashiro, K | 1 |
| Fumoto, S; Miyamoto, H; Nishida, K; Tanaka, M; Wang, S | 1 |
| Brown, PD; Bryant, A; Chung, C | 1 |
| Bhandari, R; Kuhad, A | 1 |
| Brooks, B; Genge, A | 1 |
| Abe, K; Hishikawa, N; Ikegami, K; Kawahara, Y; Matsumoto, N; Nakano, Y; Nomura, E; Ohta, Y; Omote, Y; Osakada, Y; Sasaki, R; Sato, K; Tadokoro, K; Takahashi, Y; Takamiya, M; Takemoto, M; Tsunoda, K; Yamashita, T; Yunoki, T | 1 |
| Kara, O; Kaymak, E; Yakan, B | 1 |
| Gupta, S; Singal, A; Soni, R; Tomar, S | 1 |
| Luo, HY; Parikh, A; Xiong, YX; Ye, QY; Zhao, LQ; Zhou, XF | 1 |
| Apple, S; Brooks, BR; Heiman-Patterson, T; Liu, S; Wiedau-Pazos, M; Zhang, J | 1 |
| Afreixo, V; Fidalgo, M; Gregório, H; Gregório, T; Magalhães, P; Ricardo Pires, J; Viseu, I | 1 |
| Kim, HJ; Park, D; Park, JM; Park, JS | 1 |
| Fukuta, T; Ikeda-Imafuku, M; Iwao, Y | 1 |
| Wang, X; Yang, D; Zhang, J; Zhang, M | 1 |
| Kara, O; Kilitci, A | 1 |
51 review(s) available for antipyrine and edaravone
| Article | Year |
|---|---|
[The development of new drugs for acute stroke].
Topics: Abciximab; Antibodies, Monoclonal; Anticoagulants; Antioxidants; Antipyrine; Aspirin; Clinical Trials as Topic; Drug Design; Edaravone; Fibrinolytic Agents; Humans; Immunoglobulin Fab Fragments; Neuroprotective Agents; Recombinant Proteins; Stroke; Tissue Plasminogen Activator | 2000 |
Edaravone Mitsubishi-Tokyo.
Topics: Antipyrine; Cardiovascular Diseases; Clinical Trials as Topic; Contraindications; Drugs, Investigational; Edaravone; Free Radical Scavengers; Humans | 2000 |
[Pharmacological and clinical profile of the free radical scavenger edaravone as a neuroprotective agent].
Topics: Animals; Antipyrine; Brain Edema; Clinical Trials as Topic; Depression, Chemical; Edaravone; Free Radical Scavengers; Humans; Lipid Peroxidation; Neuroprotective Agents; Rats; Stroke; Treatment Outcome | 2002 |
[Neuroprotective therapy for the treatment of acute ischemic stroke].
Topics: Animals; Antioxidants; Antipyrine; Clinical Trials as Topic; Edaravone; Free Radical Scavengers; Humans; Hypothermia, Induced; Neuroprotective Agents; Niacinamide; Stroke; Time Factors | 2001 |
Analysis of carbohydrates as 1-phenyl-3-methyl-5-pyrazolone derivatives by capillary/microchip electrophoresis and capillary electrochromatography.
Topics: Antipyrine; Carbohydrates; Chromatography; Edaravone; Electrophoresis, Capillary; Mass Spectrometry; Oligonucleotide Array Sequence Analysis | 2003 |
[Research and development of the free radical scavenger edaravone as a neuroprotectant].
Topics: Animals; Antipyrine; Brain Ischemia; Clinical Trials as Topic; Drug Design; Edaravone; Edema; Free Radical Scavengers; Humans; Neuroprotective Agents; Oxidative Stress | 2004 |
[Advances in the diagnosis and treatment of cerebral ischemia during the acute phase].
Topics: Acute-Phase Reaction; Antipyrine; Brain Ischemia; Cerebrovascular Circulation; Drug Design; Drug Therapy, Combination; Edaravone; Humans; Immunosuppressive Agents; Magnetic Resonance Imaging; Nerve Growth Factors; Neuroprotective Agents; Niacinamide; Recombinant Proteins; Tacrolimus; Time Factors; Tissue Plasminogen Activator | 2003 |
[Gene therapy and neuroprotection for cerebral infarction].
Topics: Adenoviridae; Animals; Antipyrine; Cerebral Infarction; Cerebrovascular Circulation; Edaravone; Free Radical Scavengers; Genetic Therapy; Genetic Vectors; Glial Cell Line-Derived Neurotrophic Factor; Humans; Nerve Growth Factors; Neuroprotective Agents | 2003 |
[Clinical guidelines for stroke].
Topics: Anticoagulants; Antipyrine; Arginine; Aspirin; Brain Edema; Edaravone; Fibrinolytic Agents; Free Radical Scavengers; Glycerol; Humans; Hyperlipidemias; Hypertension; Japan; Methacrylates; Pipecolic Acids; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk Factors; Stroke; Sulfonamides; Thrombolytic Therapy; Time Factors; Warfarin | 2004 |
[Treatment of cerebral infarction patients with IGT].
Topics: Antidepressive Agents; Antipyrine; Atorvastatin; Cerebral Infarction; Edaravone; Free Radical Scavengers; Glucose Intolerance; Heptanoic Acids; Humans; Hyperglycemia; Hypertension; Hypertriglyceridemia; Insulin Resistance; Pyrroles; Secondary Prevention; Thrombolytic Therapy | 2005 |
Free radical trapping as a therapeutic approach to neuroprotection in stroke: experimental and clinical studies with NXY-059 and free radical scavengers.
Topics: Animals; Antioxidants; Antipyrine; Azoles; Benzenesulfonates; Brain Ischemia; Edaravone; Free Radical Scavengers; Humans; Isoindoles; Mice; Mice, Mutant Strains; Neuroprotective Agents; Nitrogen Oxides; Organoselenium Compounds; Pregnatrienes; Rats; Reactive Oxygen Species; Stroke; Treatment Failure; Treatment Outcome | 2005 |
Neuroprotective effects of edaravone: a novel free radical scavenger in cerebrovascular injury.
Topics: Animals; Antipyrine; Cerebrovascular Disorders; Edaravone; Free Radical Scavengers; Humans; Models, Biological; Neuroprotective Agents; Nitric Oxide | 2006 |
[Advanced medical therapy in patients with acute ischemic stroke].
Topics: Administration, Oral; Anticoagulants; Antipyrine; Arginine; Aspirin; Drug Design; Edaravone; Fibrinolytic Agents; Genomics; Heparin; Humans; Infusions, Intravenous; Pipecolic Acids; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Stroke; Sulfonamides; Time Factors; Tissue Plasminogen Activator | 2006 |
[Edaravone].
Topics: Antipyrine; Cerebral Infarction; Edaravone; Free Radical Scavengers; Humans | 2006 |
Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a novel free radical scavenger, for treatment of cardiovascular diseases.
Topics: Animals; Antioxidants; Antipyrine; Cardiovascular Diseases; Cerebrovascular Disorders; Edaravone; Endothelium, Vascular; Free Radical Scavengers; Humans; Oxidative Stress; Reactive Oxygen Species | 2006 |
Novel treatments for cerebral vasospasm following aneurysmal subarachnoid hemorrhage.
Topics: Animals; Anti-Inflammatory Agents; Antipyrine; Edaravone; Fibrinolytic Agents; Free Radical Scavengers; Haptoglobins; Humans; Subarachnoid Hemorrhage; Vasospasm, Intracranial | 2008 |
Antioxidants and neuroprotection in the adult and developing central nervous system.
Topics: Animals; Antioxidants; Antipyrine; Apoptosis; Central Nervous System; Edaravone; Free Radical Scavengers; Humans; Melatonin; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Oxidative Stress | 2008 |
[Thrombolysis by intravenous tissue plasminogen activator (t-PA)--current status and future direction].
Topics: Antipyrine; Aortic Aneurysm, Thoracic; Aortic Dissection; Edaravone; Free Radical Scavengers; Humans; Infarction, Middle Cerebral Artery; Magnetic Resonance Imaging; Neuroprotective Agents; Stroke; Thrombolytic Therapy; Time Factors; Tissue Plasminogen Activator; Tomography, X-Ray Computed | 2009 |
[Neuroprotective therapy for ischemic stroke with free radical scavenger and gene-stem cell therapy].
Topics: Animals; Antipyrine; Cell- and Tissue-Based Therapy; Drug Therapy, Combination; Edaravone; Free Radical Scavengers; Genetic Therapy; Humans; Regenerative Medicine; Stroke; Thrombolytic Therapy; Tissue Plasminogen Activator | 2008 |
Edaravone for the treatment of acute cerebral infarction: role of endothelium-derived nitric oxide and oxidative stress.
Topics: Acute Disease; Antipyrine; Cerebral Infarction; Edaravone; Endothelium, Vascular; Free Radical Scavengers; Humans; Nitric Oxide; Oxidative Stress | 2009 |
[Topics of the brain protection in neonate, which has been your better choice, the brain hypothermia or the medicine?].
Topics: Allopurinol; Antioxidants; Antipyrine; Edaravone; Erythropoietin; Free Radical Scavengers; Free Radicals; Humans; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant, Newborn; Neuroprotective Agents; Oxidative Stress | 2009 |
A critical assessment of edaravone acute ischemic stroke efficacy trials: is edaravone an effective neuroprotective therapy?
Topics: Animals; Antipyrine; Brain Ischemia; Drug Evaluation, Preclinical; Edaravone; Free Radical Scavengers; Humans; Neuroprotective Agents; Stroke; Translational Research, Biomedical | 2010 |
Edaravone for acute intracerebral haemorrhage.
Topics: Antipyrine; Cerebral Hemorrhage; Edaravone; Free Radical Scavengers; Humans; Randomized Controlled Trials as Topic | 2011 |
[Future neuroprotective strategies in the post-thrombolysis era--neurovascular unit protection and vascular endothelial protection].
Topics: Amines; Animals; Antipyrine; Cerebral Infarction; Cyclohexanecarboxylic Acids; Edaravone; Endothelium, Vascular; Free Radical Scavengers; Gabapentin; gamma-Aminobutyric Acid; Humans; Thrombolytic Therapy; Tissue Plasminogen Activator | 2011 |
Antioxidant therapy: current status and future prospects.
Topics: Acetylcysteine; Animals; Antioxidants; Antipyrine; Ascorbic Acid; Edaravone; Humans; Polyphenols; Thioctic Acid; Ubiquinone; Vitamin A; Vitamin E | 2011 |
[Stimulative effect of edaravone on growth of neuronal stem cells and precursor cells following lesioning of hippocampal dentate gyrus].
Topics: Animals; Antipyrine; Cells, Cultured; Dentate Gyrus; Edaravone; Free Radical Scavengers; Hippocampus; Humans; Mice; Neural Stem Cells; Neurodegenerative Diseases; Neurogenesis; Stimulation, Chemical; Trimethyltin Compounds | 2011 |
[Concept of branch atheromatous disease (BAD) and its clinical significance].
Topics: Antipyrine; Arginine; Cerebral Infarction; Cilostazol; Drug Therapy, Combination; Edaravone; Humans; Intracranial Arteriosclerosis; Ischemic Attack, Transient; Pipecolic Acids; Platelet Aggregation Inhibitors; Sulfonamides; Tetrazoles | 2010 |
Beyond neurological disease: new targets for edaravone (Review).
Topics: Animals; Antipyrine; Apoptosis; Cardiovascular Diseases; Edaravone; Free Radical Scavengers; Free Radicals; Heart; Humans; Liver; Lung; Mice; Necrosis; Nitric Oxide; Oxidative Stress; Pancreas; Rats; Wounds and Injuries | 2011 |
Edaravone for acute ischaemic stroke.
Topics: Antipyrine; Brain Ischemia; Edaravone; Free Radical Scavengers; Humans; Neuroprotective Agents; Randomized Controlled Trials as Topic; Stroke | 2011 |
The efficacy of edaravone (radicut), a free radical scavenger, for cardiovascular disease.
Topics: Animals; Antipyrine; Cardiovascular Diseases; Edaravone; Free Radical Scavengers; Gene Expression; Humans; Nitric Oxide Synthase; Reactive Oxygen Species; Stroke | 2013 |
Edaravone for acute stroke: Meta-analyses of data from randomized controlled trials.
Topics: Antipyrine; Edaravone; Free Radical Scavengers; Humans; Randomized Controlled Trials as Topic; Stroke | 2015 |
Edaravone improves functional and structural outcomes in animal models of focal cerebral ischemia: a systematic review.
Topics: Animals; Antipyrine; Brain; Brain Ischemia; Disease Models, Animal; Edaravone; Free Radical Scavengers; Neuroprotective Agents; Recovery of Function | 2014 |
Efficacy and safety of therapies for acute ischemic stroke in China: a network meta-analysis of 13289 patients from 145 randomized controlled trials.
Topics: Aged; Antipyrine; Bayes Theorem; China; Coagulants; Drug Therapy, Combination; Edaravone; Fibrinolytic Agents; Free Radical Scavengers; Humans; Kallikreins; Methacrylates; Randomized Controlled Trials as Topic; Stroke; Treatment Outcome | 2014 |
Pathophysiology and Treatments of Oxidative Injury in Ischemic Stroke: Focus on the Phagocytic NADPH Oxidase 2.
Topics: Animals; Antioxidants; Antipyrine; Azoles; Brain; Edaravone; Humans; Isoindoles; Membrane Glycoproteins; NADPH Oxidase 2; NADPH Oxidases; Organoselenium Compounds; Oxidation-Reduction; Oxidative Stress; Phagocytosis; Reactive Oxygen Species; Signal Transduction; Stroke | 2015 |
[Concept, pathophysiology and treatment for branch atheromatous disease].
Topics: Antipyrine; Arginine; Cerebral Infarction; Cilostazol; Clopidogrel; Contraindications; Drug Therapy, Combination; Edaravone; Humans; Magnetic Resonance Imaging; Pipecolic Acids; Plaque, Atherosclerotic; Platelet Aggregation Inhibitors; Sulfonamides; Tetrazoles; Ticlopidine; Tissue Plasminogen Activator | 2014 |
Edaravone's free radical scavenging mechanisms of neuroprotection against cerebral ischemia: review of the literature.
Topics: Animals; Antipyrine; Brain Ischemia; Databases, Bibliographic; Edaravone; Free Radical Scavengers; Humans | 2015 |
Effect of edaravone on favorable outcome in patients with acute cerebral large vessel occlusion: subanalysis of RESCUE-Japan Registry.
Topics: Aged; Aged, 80 and over; Antipyrine; Cerebrovascular Disorders; Edaravone; Female; Free Radical Scavengers; Humans; Japan; Male; Middle Aged; Registries; Retrospective Studies; Treatment Outcome | 2015 |
Novel therapies in development that inhibit motor neuron hyperexcitability in amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Antipyrine; Edaravone; Humans; Motor Neurons; Neuroprotective Agents; Riluzole | 2016 |
[History and current status of medical treatment for stroke].
Topics: Anticoagulants; Antihypertensive Agents; Antipyrine; Edaravone; Fibrinolytic Agents; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Neuroprostanes; Platelet Aggregation Inhibitors; Recombinant Proteins; Risk Factors; Risk Management; Stroke; Thrombolytic Therapy; Tissue Plasminogen Activator | 2016 |
Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with lateral medullary syndrome: case report and literature review.
Topics: Aged; Antipyrine; Arginine; Clopidogrel; Diffusion Magnetic Resonance Imaging; Diuretics; Edaravone; Free Radical Scavengers; Furosemide; Humans; Hyponatremia; Inappropriate ADH Syndrome; Lateral Medullary Syndrome; Male; Pipecolic Acids; Platelet Aggregation Inhibitors; Sulfonamides; Ticlopidine | 2016 |
[Recent Progress in Cerebroprotective Therapy].
Topics: Animals; Antipyrine; Brain Diseases; Clinical Trials as Topic; Cytoprotection; Edaravone; Free Radical Scavengers; Humans | 2016 |
Retinal Diseases Associated with Oxidative Stress and the Effects of a Free Radical Scavenger (Edaravone).
Topics: Animals; Antipyrine; Edaravone; Free Radical Scavengers; Humans; Oxidative Stress; Retinal Diseases | 2017 |
Drugs in clinical development for the treatment of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Antipyrine; Biological Therapy; Biomarkers; Cell- and Tissue-Based Therapy; Drug Design; Drug Repositioning; Drugs, Investigational; Edaravone; Humans | 2017 |
Clinical efficacy of edaravone for the treatment of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Antipyrine; Disease Models, Animal; Edaravone; Free Radical Scavengers; Humans; Randomized Controlled Trials as Topic; Time Factors; Treatment Outcome; Tyrosine | 2017 |
Edaravone and its clinical development for amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Antipyrine; Clinical Trials as Topic; Edaravone; Free Radical Scavengers; Humans; Oxidative Stress | 2017 |
What can we learn from the edaravone development program for ALS?
Topics: Amyotrophic Lateral Sclerosis; Antipyrine; Clinical Trials as Topic; Edaravone; Free Radical Scavengers; Humans; Program Development | 2017 |
July 2017 ENCALS statement on edaravone.
Topics: Amyotrophic Lateral Sclerosis; Antipyrine; Decision Making; Edaravone; Free Radical Scavengers; Humans; Treatment Outcome | 2017 |
Interventions for the treatment of brain radionecrosis after radiotherapy or radiosurgery.
Topics: Adrenal Cortex Hormones; Adult; Antipyrine; Bevacizumab; Brain; Brain Edema; Drug Therapy, Combination; Edaravone; Gadolinium; Humans; Non-Randomized Controlled Trials as Topic; Radiation Injuries; Radiosurgery; Radiotherapy; Randomized Controlled Trials as Topic | 2018 |
Edaravone: a new hope for deadly amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Antipyrine; Edaravone; Free Radical Scavengers; Humans; Neuroprotective Agents | 2018 |
Edaravone for acute ischemic stroke - Systematic review with meta-analysis.
Topics: Adult; Antipyrine; Brain Ischemia; Edaravone; Free Radical Scavengers; Humans; Intracranial Hemorrhages; Ischemic Stroke; Stroke; Treatment Outcome | 2022 |
Clinical Efficacy and Short-Term Prognosis of Butylphthalide and Sodium Chloride Injection Compared to Edaravone in the Treatment of Patients with Acute Stroke.
Topics: Antipyrine; Edaravone; Humans; Sodium Chloride; Stroke; Treatment Outcome | 2023 |
39 trial(s) available for antipyrine and edaravone
| Article | Year |
|---|---|
Influence of subject age on the inhibition of oxidative metabolism by ciprofloxacin.
Topics: Adult; Aged; Aged, 80 and over; Aging; Antipyrine; Ciprofloxacin; Edaravone; Female; Humans; Male; Oxidation-Reduction; Prospective Studies | 1991 |
Elimination studies of antipyrine and its metabolites in healthy Saudi Arabians.
Topics: Administration, Oral; Adolescent; Adult; Antipyrine; Asian People; Black People; Chromatography, High Pressure Liquid; Edaravone; Female; Humans; Male; Metabolic Clearance Rate; Saudi Arabia; White People | 1994 |
[Experience of biologically active supplements to food containing indoles and isothiocyanates in patients with chronic viral hepatitis].
Topics: Adolescent; Adult; Alanine Transaminase; Antipyrine; Aspartate Aminotransferases; Bilirubin; Case-Control Studies; Dietary Supplements; Edaravone; Female; Hepatitis B, Chronic; Hepatitis C, Chronic; Humans; Inactivation, Metabolic; Indoles; Isothiocyanates; Liver; Male | 2002 |
Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Antipyrine; Cerebral Infarction; Double-Blind Method; Edaravone; Female; Free Radical Scavengers; Humans; Male; Middle Aged; Neuropsychological Tests; Treatment Outcome | 2003 |
Free radical scavenger, edaravone, in stroke with internal carotid artery occlusion.
Topics: Aged; Antipyrine; Atrial Fibrillation; Brain Edema; Carotid Artery Thrombosis; Carotid Artery, Internal; Cerebral Infarction; Cohort Studies; Edaravone; Female; Free Radical Scavengers; Functional Laterality; Humans; Infusions, Intravenous; Male; Risk Factors; Survival Analysis; Treatment Outcome | 2004 |
Effects of edaravone on reperfusion injury in patients with acute myocardial infarction.
Topics: Aged; Angioplasty, Balloon, Coronary; Antipyrine; Creatine Kinase; Creatine Kinase, MB Form; Edaravone; Female; Free Radical Scavengers; Humans; Isoenzymes; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion Injury; Pilot Projects; Stents; Thrombolytic Therapy; Treatment Outcome | 2004 |
Effects of the free radical scavenger, edaravone, on the development of postoperative cognitive impairment in patients undergoing carotid endarterectomy.
Topics: Aged; Antipyrine; Carotid Artery, Internal; Carotid Stenosis; Cerebral Infarction; Cerebrovascular Circulation; Cognition Disorders; Cohort Studies; Edaravone; Endarterectomy, Carotid; Female; Free Radical Scavengers; Humans; Hypoxia-Ischemia, Brain; Hypoxia, Brain; Male; Middle Aged; Neuropsychological Tests; Postoperative Complications; Treatment Outcome | 2005 |
Inhibition of brain damage by edaravone, a free radical scavenger, can be monitored by plasma biomarkers that detect oxidative and astrocyte damage in patients with acute cerebral infarction.
Topics: Adult; Aged; Aged, 80 and over; Antipyrine; Astrocytes; Biomarkers; Cerebral Infarction; Edaravone; Female; Free Radical Scavengers; Humans; Lipoproteins, LDL; Male; Middle Aged; Monitoring, Physiologic; Nerve Growth Factors; Oxidative Stress; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Superoxide Dismutase; Treatment Outcome | 2005 |
Long-term efficacy of edaravone in patients with acute myocardial infarction.
Topics: Acute Disease; Antipyrine; Arrhythmias, Cardiac; Edaravone; Free Radical Scavengers; Humans; Myocardial Infarction; Myocardial Reperfusion Injury; Oxidative Stress; Retrospective Studies; Thioredoxins; Time Factors | 2006 |
Hyperbaric oxygen combined with intravenous edaravone for treatment of acute embolic stroke: a pilot clinical trial.
Topics: Acute Disease; Aged; Antipyrine; Combined Modality Therapy; Edaravone; Emergency Medical Services; Female; Free Radical Scavengers; Humans; Hyperbaric Oxygenation; Intracranial Embolism; Male; Neuroprotective Agents; Pilot Projects; Severity of Illness Index; Stroke | 2006 |
Investigation of the therapeutic effects of edaravone, a free radical scavenger, on amyotrophic lateral sclerosis (Phase II study).
Topics: Amyotrophic Lateral Sclerosis; Antipyrine; Dose-Response Relationship, Drug; Edaravone; Female; Free Radical Scavengers; Humans; Male; Middle Aged; Treatment Outcome | 2006 |
Effect of a free radical scavenger, edaravone, in the treatment of patients with aneurysmal subarachnoid hemorrhage.
Topics: Antipyrine; Cerebral Infarction; Comorbidity; Edaravone; Female; Free Radical Scavengers; Humans; Japan; Male; Middle Aged; Prevalence; Risk Assessment; Risk Factors; Subarachnoid Hemorrhage; Treatment Outcome; Vasospasm, Intracranial | 2009 |
Edaravone (radical scavenger) versus sodium ozagrel (antiplatelet agent) in acute noncardioembolic ischemic stroke (EDO trial).
Topics: Aged; Aged, 80 and over; Antipyrine; Edaravone; Female; Free Radical Scavengers; Humans; Japan; Male; Methacrylates; Middle Aged; Platelet Aggregation Inhibitors; Stroke; Treatment Outcome | 2009 |
Edaravone, a free radical scavenger, in the treatment of idiopathic sudden sensorineural hearing loss with profound hearing loss.
Topics: Adult; Aged; Antipyrine; Audiometry, Pure-Tone; Edaravone; Female; Free Radical Scavengers; Hearing Loss, Sensorineural; Humans; Hyperbaric Oxygenation; Male; Middle Aged; Severity of Illness Index; Young Adult | 2010 |
Edaravone (MCI-186) is effective as a free radical scavenger following arteriovenous sheathotomy for treatment of macular oedema associated with branch retinal vein occlusion.
Topics: Adult; Aged; Antipyrine; Edaravone; Female; Free Radical Scavengers; Humans; Macular Edema; Male; Middle Aged; Postoperative Care; Retinal Vein Occlusion; Vascular Surgical Procedures; Visual Acuity; Vitrectomy | 2009 |
Effect of edaravone on plasma monocyte chemoattractant protein-1 levels in patients with acute myocardial infarction.
Topics: Aged; Angioplasty, Balloon, Coronary; Antipyrine; Biomarkers; Chemokine CCL2; Edaravone; Female; Free Radical Scavengers; Heart Failure; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion Injury; Patient Readmission; Prognosis; Stroke Volume; Ventricular Function, Left | 2009 |
Effects of edaravone on muscle atrophy and locomotor function in patients with ischemic stroke: a randomized controlled pilot study.
Topics: Aged; Antipyrine; Brain Ischemia; Drug Administration Schedule; Edaravone; Female; Free Radical Scavengers; Humans; Infusions, Intravenous; Leg; Male; Muscular Atrophy; Paresis; Pilot Projects; Recovery of Function; Severity of Illness Index; Stroke; Walking | 2010 |
Free radical scavenger, edaravone, reduces the lesion size of lacunar infarction in human brain ischemic stroke.
Topics: Activities of Daily Living; Aged; Antipyrine; Brain Infarction; Diffusion Magnetic Resonance Imaging; Edaravone; Female; Free Radical Scavengers; Humans; Magnetic Resonance Angiography; Male; Recovery of Function; Stroke | 2011 |
Administration of edaravone, a free radical scavenger, during t-PA infusion can enhance early recanalization in acute stroke patients--a preliminary study.
Topics: Aged; Aged, 80 and over; Antipyrine; Edaravone; Female; Free Radical Scavengers; Humans; Infusions, Intravenous; Male; Prospective Studies; Recovery of Function; Single-Blind Method; Stroke; Time Factors; Tissue Plasminogen Activator; Treatment Outcome | 2012 |
Prognostic significance of smoking in patients with acute ischemic stroke within 3 months of onset.
Topics: Aged; Aged, 80 and over; Antipyrine; Arginine; Brain Ischemia; Chi-Square Distribution; Disability Evaluation; Drug Therapy, Combination; Edaravone; Female; Fibrinolytic Agents; Humans; Japan; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Pipecolic Acids; Recovery of Function; Risk Factors; Smoking; Smoking Cessation; Smoking Prevention; Stroke; Sulfonamides; Time Factors; Treatment Outcome | 2013 |
Phase I clinical study of edaravone in healthy Chinese volunteers: safety and pharmacokinetics of single or multiple intravenous infusions.
Topics: Adult; Antipyrine; Area Under Curve; Asian People; China; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Edaravone; Female; Free Radical Scavengers; Humans; Infusions, Intravenous; Male; Time Factors; Young Adult | 2012 |
Edaravone - citicoline comparative study in acute ischemic stroke (ECCS-AIS).
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Antipyrine; Brain Ischemia; Cytidine Diphosphate Choline; Edaravone; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neuroprotective Agents; Stroke; Treatment Outcome; Young Adult | 2012 |
Effects of smoking on outcomes after acute atherothrombotic stroke in Japanese men.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antipyrine; Antithrombins; Arginine; Asian People; Body Temperature; Case-Control Studies; Edaravone; Humans; Logistic Models; Male; Pipecolic Acids; Retrospective Studies; Severity of Illness Index; Smoking; Stroke; Sulfonamides; Treatment Outcome; Young Adult | 2013 |
Safety, tolerability and pharmacokinetics of MCI-186 in patients with acute ischemic stroke: new formulation and dosing regimen.
Topics: Aged; Aged, 80 and over; Antipyrine; Dose-Response Relationship, Drug; Double-Blind Method; Edaravone; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Stroke; Treatment Outcome | 2013 |
Effect of edaravone on radiation-induced brain necrosis in patients with nasopharyngeal carcinoma after radiotherapy: a randomized controlled trial.
Topics: Adult; Aged; Aged, 80 and over; Antipyrine; Brain Injuries; Carcinoma; Case-Control Studies; Edaravone; Female; Follow-Up Studies; Free Radical Scavengers; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Necrosis; Neoplasm Staging; Prognosis; Prospective Studies; Radiation Injuries; Radiotherapy | 2014 |
Confirmatory double-blind, parallel-group, placebo-controlled study of efficacy and safety of edaravone (MCI-186) in amyotrophic lateral sclerosis patients.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Analysis of Variance; Antipyrine; Double-Blind Method; Edaravone; Female; Follow-Up Studies; Free Radical Scavengers; Humans; Male; Middle Aged; Retrospective Studies; Severity of Illness Index; Time Factors; Young Adult | 2014 |
Increased oxidative stress in patients with amyotrophic lateral sclerosis and the effect of edaravone administration.
Topics: Aged; Amyotrophic Lateral Sclerosis; Antipyrine; Biomarkers; Edaravone; Fatty Acids, Nonesterified; Female; Free Radical Scavengers; Humans; Male; Middle Aged; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Ubiquinone; Uric Acid | 2016 |
Edaravone offers neuroprotection for acute diabetic stroke patients.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Antipyrine; Diabetes Mellitus; Double-Blind Method; Edaravone; Female; Free Radical Scavengers; Humans; Male; Middle Aged; Neuroprotective Agents; Platelet Aggregation Inhibitors; Stroke; Treatment Outcome | 2016 |
Edaravone Reduces Hyperperfusion-Related Neurological Deficits in Adult Moyamoya Disease: Historical Control Study.
Topics: Adult; Aged; Anastomosis, Surgical; Antipyrine; Cerebral Revascularization; Cerebrovascular Circulation; Edaravone; Female; Free Radical Scavengers; Historically Controlled Study; Humans; Male; Middle Aged; Middle Cerebral Artery; Moyamoya Disease; Nervous System Diseases; Postoperative Complications; Temporal Arteries; Young Adult | 2016 |
Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Antipyrine; Double-Blind Method; Edaravone; Female; Free Radical Scavengers; Humans; Male; Middle Aged; Outcome Assessment, Health Care; Severity of Illness Index; Young Adult | 2017 |
Post-hoc analysis of randomised, placebo-controlled, double-blind study (MCI186-19) of edaravone (MCI-186) in amyotrophic lateral sclerosis.
Topics: Aged; Amyotrophic Lateral Sclerosis; Antipyrine; Double-Blind Method; Edaravone; Female; Free Radical Scavengers; Humans; Male; Middle Aged | 2017 |
Post-hoc analysis of MCI186-17, the extension study to MCI186-16, the confirmatory double-blind, parallel-group, placebo-controlled study of edaravone in amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Antipyrine; Double-Blind Method; Edaravone; Female; Free Radical Scavengers; Humans; Male; Middle Aged; Placebo Effect; Prospective Studies; Vital Capacity | 2017 |
Exploratory double-blind, parallel-group, placebo-controlled study of edaravone (MCI-186) in amyotrophic lateral sclerosis (Japan ALS severity classification: Grade 3, requiring assistance for eating, excretion or ambulation).
Topics: Activities of Daily Living; Adult; Aged; Amyotrophic Lateral Sclerosis; Antipyrine; Double-Blind Method; Eating; Edaravone; Female; Free Radical Scavengers; Humans; Japan; Male; Middle Aged; Mobility Limitation; Placebo Effect; Severity of Illness Index | 2017 |
Post-hoc analysis of open-label extension period of study MCI186-19 in amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Antipyrine; Double-Blind Method; Edaravone; Female; Free Radical Scavengers; Hand Strength; Humans; Male; Prospective Studies | 2017 |
A post-hoc subgroup analysis of outcomes in the first phase III clinical study of edaravone (MCI-186) in amyotrophic lateral sclerosis.
Topics: Aged; Amyotrophic Lateral Sclerosis; Antipyrine; Double-Blind Method; Edaravone; Female; Free Radical Scavengers; Humans; Male; Middle Aged; Treatment Outcome | 2017 |
Exploratory double-blind, parallel-group, placebo-controlled extension study of edaravone (MCI-186) in amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Antipyrine; Double-Blind Method; Edaravone; Female; Free Radical Scavengers; Humans; Male; Middle Aged; Placebo Effect | 2017 |
A safety analysis of edaravone (MCI-186) during the first six cycles (24 weeks) of amyotrophic lateral sclerosis (ALS) therapy from the double-blind period in three randomized, placebo-controlled studies.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Antipyrine; Double-Blind Method; Edaravone; Female; Free Radical Scavengers; Humans; Male; Middle Aged; Patient Safety; Respiration Disorders | 2017 |
Open-label 24-week extension study of edaravone (MCI-186) in amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Antipyrine; Double-Blind Method; Edaravone; Female; Free Radical Scavengers; Humans; Male; Middle Aged; Nasopharyngitis; Respiration Disorders; Survival Rate | 2017 |
Edaravone efficacy in amyotrophic lateral sclerosis with reduced forced vital capacity: Post-hoc analysis of Study 19 (MCI186-19) [clinical trial NCT01492686].
Topics: Amyotrophic Lateral Sclerosis; Antipyrine; Double-Blind Method; Edaravone; Free Radical Scavengers; Humans; Vital Capacity | 2022 |
679 other study(ies) available for antipyrine and edaravone
| Article | Year |
|---|---|
High-performance capillary electrophoresis of unsaturated oligosaccharides derived from glycosaminoglycans by digestion with chondroitinase ABC as 1-phenyl-3-methyl-5-pyrazolone derivatives.
Topics: Antipyrine; Chondroitin Lyases; Chromatography, Ion Exchange; Creatinine; Edaravone; Electrophoresis; Glycosaminoglycans; Humans; Hydrolysis; Oligosaccharides | 1992 |
Disposition of antipyrine in patients with extensive metastatic liver disease.
Topics: Adenocarcinoma; Aged; Antipyrine; Colorectal Neoplasms; Edaravone; Female; Humans; Liver Neoplasms; Male; Middle Aged | 1992 |
The pharmacokinetics of antipyrine and three of its metabolites in the rabbit: intravenous administration of pure metabolites.
Topics: Animals; Antipyrine; Chromatography, High Pressure Liquid; Edaravone; Injections, Intravenous; Male; Mass Spectrometry; Rabbits | 1991 |
High-performance liquid chromatographic method for the determination of the three main oxidative and 3-carboxylic antipyrine metabolites in human urine.
Topics: Antipyrine; Chromatography, High Pressure Liquid; Edaravone; Humans; Indicators and Reagents; Oxidation-Reduction | 1991 |
[The determination of the oxidation phenotype in inbred C57Bl/6 and BALB/c mice].
Topics: Animals; Antipyrine; Chromatography, Gas; Edaravone; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Oxidation-Reduction; Phenotype; Time Factors | 1990 |
The control of vascular endothelial cell injury.
Topics: Animals; Antipyrine; Cattle; Cells, Cultured; Edaravone; Endothelium, Vascular; Free Radical Scavengers; Leukocytes; Leukotrienes; Lipid Peroxides; Luminescent Measurements; Tetradecanoylphorbol Acetate | 1990 |
The effect of age on the oxidative metabolism of antipyrine by uninduced microsomal fractions of rat liver.
Topics: Aging; Animals; Antipyrine; Cytochrome P-450 Enzyme System; Edaravone; In Vitro Techniques; Isoenzymes; Kinetics; Male; Microsomes, Liver; Oxidation-Reduction; Rats; Rats, Inbred BN | 1990 |
Assay of antipyrine and its main metabolites 3-hydroxymethylantipyrine, norantipyrine and 4-hydroxyantipyrine in urine.
Topics: Antipyrine; Chromatography, High Pressure Liquid; Edaravone; Glucuronidase; Humans; Hydrogen-Ion Concentration; Indicators and Reagents; Spectrophotometry, Ultraviolet | 1989 |
Effect of MCI-186 on brain edema in rats.
Topics: Animals; Antipyrine; Brain Edema; Dexamethasone; Edaravone; Free Radicals; Lipid Peroxides; Lipoxygenase; Male; Polyvinyls; Potassium; Rats; Rats, Inbred Strains; Sodium | 1989 |
Modified high-performance liquid chromatographic assay for antipyrine and its three major metabolites in urine.
Topics: Antipyrine; Chromatography, High Pressure Liquid; Edaravone; Humans | 1989 |
Effect of MCI-186 on ischemia-induced changes in monoamine metabolism in rat brain.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antipyrine; Biogenic Monoamines; Brain; Brain Edema; Brain Ischemia; Brain Stem; Dopamine; Edaravone; Homovanillic Acid; Kinetics; Male; Norepinephrine; Polyvinyls; Rats; Rats, Inbred Strains; Serotonin; Telencephalon | 1989 |
High-performance liquid chromatography of reducing carbohydrates as strongly ultraviolet-absorbing and electrochemically sensitive 1-phenyl-3-methyl-5-pyrazolone derivatives.
Topics: Animals; Antipyrine; Carbohydrates; Carbon Isotopes; Cattle; Chickens; Chromatography, High Pressure Liquid; Edaravone; Electrochemistry; Female; Glucose; Glycoproteins; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Monosaccharides; Oligosaccharides; Reference Standards; Reproducibility of Results; Spectrophotometry, Ultraviolet; Swine | 1989 |
[Alterations of urinary excretion of antipyrine metabolites in patients with cirrhosis of the liver].
Topics: Antipyrine; Carcinoma, Hepatocellular; Edaravone; Female; Humans; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged | 1987 |
Temporal effects on antipyrine metabolite kinetics in Aroclor 1254-treated rats.
Topics: Animals; Antipyrine; Aroclors; Breath Tests; Carbon Dioxide; Carbon Radioisotopes; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Edaravone; Enzyme Induction; Half-Life; Injections, Intraperitoneal; Kinetics; Liver; Male; Rats; Rats, Inbred Strains | 1986 |
Antipyrine clearance and metabolite formation: the influence of liver volume and smoking.
Topics: Adult; Antipyrine; Cytochrome P-450 Enzyme System; Edaravone; Female; Humans; Kinetics; Liver; Male; Middle Aged; Organ Size; Smoking | 1986 |
Preventive effect of MCI-186 on 15-HPETE induced vascular endothelial cell injury in vitro.
Topics: Animals; Antipyrine; Arachidonic Acid; Arachidonic Acids; Cattle; Cells, Cultured; Edaravone; Endothelium, Vascular; Epoprostenol; Leukotriene Antagonists; Leukotrienes; Lipid Peroxides; Phenols; Prostaglandins | 1988 |
Improved high-performance liquid chromatographic assay of antipyrine, hydroxymethylantipyrine, 4-hydroxyantipyrine and norantipyrine in urine.
Topics: Antipyrine; Chromatography, High Pressure Liquid; Edaravone; Reference Standards | 1988 |
Activation of carcinogens by peroxidase. Horseradish peroxidase-mediated formation of benzenediazonium ion from a non-aminoazo dye, 1-phenylazo-2-hydroxynaphthalene (Sudan I) and its binding to DNA.
Topics: Animals; Antipyrine; Carcinogens; Cattle; Diazonium Compounds; DNA; Edaravone; Horseradish Peroxidase; Hydrogen Peroxide; Naphthols; Oxidation-Reduction; Peroxidases; Spectrophotometry | 1988 |
The first identification of the benzenediazonium ion formation from a non-aminoazo dye, 1-phenylazo-2-hydroxynaphthalene (Sudan I) by microsomes of rat livers.
Topics: Animals; Antipyrine; Benzoflavones; Biotransformation; Carcinogens; Chromatography, Thin Layer; Coloring Agents; Diazonium Compounds; Edaravone; Male; Microsomes, Liver; Naphthols; Rats; Rats, Inbred Strains | 1988 |
Antipyrine metabolism in cultured rat hepatocytes.
Topics: Animals; Antipyrine; Cells, Cultured; Chloramphenicol; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Edaravone; Isoenzymes; Kinetics; Liver; Male; Rats; Rats, Inbred Strains | 1987 |
The effect of verapamil on antipyrine pharmacokinetics and metabolism in man.
Topics: Adult; Antipyrine; Drug Interactions; Edaravone; Half-Life; Humans; Kinetics; Male; Metabolic Clearance Rate; Verapamil | 1986 |
Antipyrine clearance and metabolism in patients with psoriasis.
Topics: Aged; Aged, 80 and over; Antipyrine; Aryl Hydrocarbon Hydroxylases; Edaravone; Female; Half-Life; Humans; Male; Middle Aged; Psoriasis; Saliva; Smoking | 1986 |
Effect of pregnenolone carbonitrile, promethazine and antipyrine pretreatment on antipyrine metabolite formation in rats.
Topics: Animals; Antipyrine; Breath Tests; Edaravone; Enzyme Induction; Kidney; Male; Mathematics; Mixed Function Oxygenases; Pregnenolone Carbonitrile; Promethazine; Rats; Rats, Inbred Strains | 1986 |
Pharmacogenetic differences in the inhibitory effect of cimetidine on the metabolism of antipyrine.
Topics: Acetylation; Adult; Antipyrine; Cimetidine; Edaravone; Female; Glucaric Acid; Humans; Male; Metabolic Clearance Rate; Microsomes, Liver; Middle Aged; Pharmacogenetics; Phenotype | 1987 |
The pharmacokinetics of mefloquine in man: lack of effect of mefloquine on antipyrine metabolism.
Topics: Adult; Antimalarials; Antipyrine; Chromatography, High Pressure Liquid; Drug Interactions; Edaravone; Humans; Kinetics; Male; Mefloquine; Metabolic Clearance Rate; Quinolines; Saliva | 1985 |
Antipyrine metabolite formation and excretion in patients with chronic renal failure.
Topics: Adult; Aged; Antipyrine; Edaravone; Female; Half-Life; Humans; Kidney Failure, Chronic; Kinetics; Male; Middle Aged; Time Factors | 1985 |
Antipyrine metabolism during hepatic regeneration in the rat.
Topics: Animals; Antipyrine; Edaravone; Female; Liver Diseases; Liver Regeneration; Organ Size; Rats; Rats, Inbred Strains; Time Factors | 1985 |
Quantitation of norantipyrine sulphate and norantipyrine glucuronide as major metabolites of antipyrine in man and rat.
Topics: Adult; Animals; Antipyrine; Chromatography, Thin Layer; Edaravone; Glucuronates; Humans; Hydrolysis; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains; Solubility; Sulfates | 1984 |
Influence of alaproclate on antipyrine metabolite formation in man.
Topics: Adult; Alanine; Antipyrine; Biotransformation; Cytochrome P-450 Enzyme System; Edaravone; Half-Life; Humans; Liver; Male; Oxidation-Reduction | 1984 |
Influence of 9-hydroxyellipticine and 3-methylcholanthrene treatment on antipyrine metabolite formation in rats in vivo.
Topics: Alkaloids; Animals; Antipyrine; Edaravone; Ellipticines; Kinetics; Methylcholanthrene; Rats; Rats, Inbred Strains | 1983 |
Automated high-performance liqiud chromatographic method for the determination of antipyrine and its metabolites in urine. Some preliminary results obtained from smokers and non-smokers.
Topics: Adult; Antipyrine; Autoanalysis; Chromatography, High Pressure Liquid; Edaravone; Female; Humans; Male; Smoking | 1982 |
Simultaneous determination of antipyrine, 4-hydroxyantipyrine, 3-hydroxymethylantipyrine and norantipyrine in urine by gas chromatography chemical ionization mass spectrometry.
Topics: Antipyrine; Edaravone; Gas Chromatography-Mass Spectrometry; Humans; Reference Standards; Time Factors | 1982 |
[Growth inhibition in Chlorella vulgaris by 4-substituted 3-methyl-1-phenylpyrazolin-5-one derivatives as related to their chemical structure].
Topics: Antipyrine; Chlorella; Edaravone; Structure-Activity Relationship | 1980 |
A radiometric high-pressure liquid chromatography assay for the simultaneous determination of the three main oxidative metabolites of antipyrine in studies in vitro.
Topics: Animals; Antipyrine; Chromatography, High Pressure Liquid; Edaravone; Gas Chromatography-Mass Spectrometry; Humans; Male; Microsomes, Liver; Rats | 1981 |
HPLC determination of antipyrine metabolites.
Topics: Antioxidants; Antipyrine; Chromatography, High Pressure Liquid; Edaravone; Humans; Hydrogen-Ion Concentration; Hydrolysis; Time Factors | 1981 |
Antipyrine metabolism in man: simultaneous determination of norantipyrine and 4-hydroxyantipyrine in urine by gas chromatography.
Topics: Adult; Antipyrine; Biotransformation; Chromatography, Gas; Dealkylation; Edaravone; Humans; Hydrolysis; Hydroxylation; Male; Middle Aged | 1980 |
Monosaccharide composition analysis of oligosaccharides and glycoproteins by high-performance liquid chromatography.
Topics: Antipyrine; Chromatography, High Pressure Liquid; Data Interpretation, Statistical; Edaravone; Glycoproteins; Hexosamines; Hexoses; Hydrolysis; Monosaccharides; Oligosaccharides; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Sialic Acids; Time Factors | 1995 |
Antipyrine clearance and metabolite excretion in patients with chronic hepatitis C.
Topics: Adult; Antipyrine; Chronic Disease; Edaravone; Female; Hepatitis C; Humans; Male; Middle Aged; Reference Values | 1995 |
Effects of an antistroke agent MCl-186 on cerebral arachidonate cascade.
Topics: Animals; Antipyrine; Arachidonic Acid; Brain; Brain Edema; Cerebrovascular Disorders; Chromones; Edaravone; Free Radical Scavengers; Gerbillinae; Male; Rats; Rats, Wistar; Superoxides | 1994 |
Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions.
Topics: Alloxan; Animals; Antioxidants; Antipyrine; Brain; Brain Ischemia; Edaravone; Embolization, Therapeutic; Energy Metabolism; Free Radical Scavengers; Hydroxyl Radical; Islets of Langerhans; Lipid Peroxidation; Male; Mitochondria; Rats; Rats, Wistar; Regional Blood Flow; Superoxides | 1994 |
Analysis of carbohydrates in glycoproteins by high-performance liquid chromatography and high-performance capillary electrophoresis.
Topics: Aminopyridines; Antipyrine; Carbohydrate Sequence; Chromatography, High Pressure Liquid; Edaravone; Electrophoresis; Glycoproteins; Molecular Sequence Data; Monosaccharides; Oligosaccharides | 1993 |
Effect of gonadal hormones on the plasma clearance and metabolite formation of antipyrine in the dwarf goat.
Topics: Animals; Antipyrine; Castration; Edaravone; Estradiol; Female; Goats; Male; Testosterone | 1993 |
Protective effects of MCI-186 on cold kidney preservation/reperfusion injury in the rat.
Topics: Animals; Antipyrine; Creatinine; Edaravone; Free Radical Scavengers; Hypertonic Solutions; In Vitro Techniques; Kidney; Nephrectomy; Organ Preservation; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 1996 |
Antipyrine as a probe for human oxidative drug metabolism: identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Autoantibodies; Biotransformation; Catalysis; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Edaravone; Gas Chromatography-Mass Spectrometry; Humans; Microsomes, Liver | 1996 |
Effect of MCI-186 on postischemic reperfusion injury in isolated rat heart.
Topics: Animals; Antioxidants; Antipyrine; Creatine Kinase; Edaravone; Free Radical Scavengers; Humans; In Vitro Techniques; Male; Myocardial Reperfusion Injury; Necrosis; Rats; Rats, Wistar; Recombinant Proteins; Risk Factors; Superoxide Dismutase | 1996 |
Effect of age on the pharmacokinetics of antipyrine in calves.
Topics: Aging; Animals; Antipyrine; Cattle; Edaravone; Female; Half-Life; Metabolic Clearance Rate; Time Factors | 1996 |
Identification of the human hepatic cytochromes P450 involved in the in vitro oxidation of antipyrine.
Topics: Antipyrine; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Edaravone; Enzyme Inhibitors; Humans; Isoenzymes; Microsomes, Liver; Oxidoreductases; Regression Analysis | 1996 |
Pharmacokinetics of antipyrine in calves after intravenous and oral administration.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Cattle; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Edaravone; Female; Free Radical Scavengers; Half-Life; Injections, Intravenous; Regression Analysis | 1996 |
Paracrine function of endothelium-derived nitric oxide.
Topics: Animals; Antipyrine; Bradykinin; Cattle; Cells, Cultured; Cyclic GMP; Cyclic N-Oxides; Edaravone; Endothelium, Vascular; Free Radical Scavengers; Imidazoles; Muscle, Smooth, Vascular; Nitric Oxide | 1995 |
The effect of cimetidine on antipyrine metabolism in calves.
Topics: Administration, Oral; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antipyrine; Cattle; Chromatography, High Pressure Liquid; Cimetidine; Drug Interactions; Edaravone; Female; Free Radical Scavengers; Histamine H2 Antagonists; Software | 1997 |
Effects of a novel free radical scavenger, MCl-186, on ischemic brain damage in the rat distal middle cerebral artery occlusion model.
Topics: Animals; Antipyrine; Brain; Brain Ischemia; Cerebral Arteries; Disease Models, Animal; Edaravone; Free Radical Scavengers; Male; Rats; Rats, Sprague-Dawley; Regional Blood Flow | 1997 |
Oligosaccharide characterization and quantitation using 1-phenyl-3-methyl-5-pyrazolone derivatization and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
Topics: alpha-Fetoproteins; Antipyrine; Chromatography, High Pressure Liquid; Disaccharides; Edaravone; Glycoproteins; Monosaccharides; Oligosaccharides; Oxidation-Reduction; Ribonucleases; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrophotometry, Ultraviolet | 1997 |
[In vitro evaluation of metabolic change in forebrain ischemia model of rat using proton magnetic resonance spectroscopy].
Topics: Acetates; Animals; Antipyrine; Brain; Brain Ischemia; Choline; Edaravone; Free Radical Scavengers; Lactates; Magnetic Resonance Spectroscopy; Male; Prosencephalon; Rats; Rats, Wistar; Reperfusion Injury | 1997 |
Delayed neuronal death prevented by inhibition of increased hydroxyl radical formation in a transient cerebral ischemia.
Topics: Animals; Antipyrine; Brain Ischemia; Cell Death; Edaravone; Free Radical Scavengers; Hippocampus; Hydroxybenzoates; Hydroxyl Radical; Iron Chelating Agents; Male; Microdialysis; Neurons; Rats; Rats, Wistar; Reperfusion Injury | 1997 |
Determination of antipyrine and metabolites in plasma of a patient with mild renal failure.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Chromatography, High Pressure Liquid; Edaravone; Female; Humans; Hypertension; Kidney Failure, Chronic; Metabolic Clearance Rate; Reference Values | 1997 |
The effect of age and sex on metabolism and urinary excretion of antipyrine.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Aging; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Body Weight; Edaravone; Female; Free Radical Scavengers; Half-Life; Humans; Kidney; Male; Metabolic Clearance Rate; Saliva; Sex Characteristics | 1998 |
Inhibitory effect of MCI-186, a free radical scavenger, on cerebral ischemia following rat middle cerebral artery occlusion.
Topics: Animals; Antipyrine; Brain; Brain Ischemia; Cerebral Arteries; Constriction; Edaravone; Free Radical Scavengers; Hydroxybenzoates; Hydroxyl Radical; Male; Rats; Rats, Wistar; Visual Cortex | 1998 |
Analysis of glucuronolactone and glucuronic acid in drug formulations by high-performance liquid chromatography.
Topics: Antipyrine; Chromatography, High Pressure Liquid; Edaravone; Glucuronates; Glucuronic Acid; Pharmaceutical Preparations; Quality Control; Reproducibility of Results; Technology, Pharmaceutical; Time Factors | 1998 |
Separation of disaccharides by affinity capillary electrophoresis in lectin-containing electrophoretic solutions.
Topics: Antipyrine; Disaccharides; Edaravone; Electrophoresis, Capillary; Lectins; Molecular Structure; Pyrazoles; Solutions | 1998 |
Separation of 1-phenyl-3-methyl-5-pyrazolone derivatives of monosaccharides by capillary electrochromatography.
Topics: Antipyrine; Chromatography, High Pressure Liquid; Edaravone; Electrophoresis, Capillary; Monosaccharides; Pyrazoles; Reproducibility of Results | 1998 |
Analysis of sialyllactoses in blood and urine by high-performance liquid chromatography.
Topics: Antipyrine; Carbohydrates; Chromatography, High Pressure Liquid; Edaravone; Free Radical Scavengers; Humans; Lactose; Oligosaccharides; Reference Standards; Sialic Acids; Temperature; Time Factors | 1999 |
Involvement of free radicals in cerebral vascular reperfusion injury evaluated in a transient focal cerebral ischemia model of rat.
Topics: Animals; Antipyrine; Brain; Caudate Nucleus; Cerebral Infarction; Cyclic N-Oxides; Disease Models, Animal; Edaravone; Free Radical Scavengers; Free Radicals; Hippocampus; Ischemic Attack, Transient; Male; Nitroarginine; Nitrogen Oxides; Putamen; Rats; Rats, Inbred F344; Rats, Wistar; Reperfusion Injury; Spin Labels; Superior Colliculi | 1999 |
Effect of 1-phenyl-3-methyl-5-pyrazolone labeling on the fragmentation behavior of asialo and sialylated N-linked glycans under electrospray ionization conditions.
Topics: Antipyrine; Carbohydrate Sequence; Chromatography, High Pressure Liquid; Edaravone; Mass Spectrometry; Molecular Sequence Data; Oligosaccharides; Polysaccharides | 1999 |
Electrospray ionization mass spectrometry of 1-phenyl-3-methyl-5-pyrazolone derivatives of neutral and N-acetylated oligosaccharides.
Topics: Acetylation; Antipyrine; Chromatography, High Pressure Liquid; Edaravone; Oligosaccharides; Sensitivity and Specificity; Spectrometry, Mass, Secondary Ion | 1999 |
Effect of experimental fasciolosis on antipyrine metabolism and clearance in water buffaloes.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Helminth; Antipyrine; Aspartate Aminotransferases; Buffaloes; Chromatography, High Pressure Liquid; Edaravone; Enzyme-Linked Immunosorbent Assay; Fascioliasis; Feces; gamma-Glutamyltransferase; Half-Life; Male; Parasite Egg Count | 2000 |
MCI-186: further histochemical and biochemical evidence of neuroprotection.
Topics: Animals; Antipyrine; Brain; Brain Infarction; Creatine Kinase; Cytochrome c Group; Edaravone; Free Radical Scavengers; Free Radicals; Hypoxanthine; Male; Neuroprotective Agents; Propyl Gallate; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Xanthine Oxidase | 2000 |
Hypoxia-reoxygenation inhibits gap junctional communication in cultured human umbilical vein endothelial cells.
Topics: Antipyrine; Catalase; Cell Communication; Cell Hypoxia; Cells, Cultured; Deferoxamine; Dimethyl Sulfoxide; Edaravone; Endothelium, Vascular; Gap Junctions; Humans; Image Cytometry; Lasers; Oxygen; Probucol; Reactive Oxygen Species; Superoxide Dismutase; Time Factors; Umbilical Veins | 2000 |
Analysis of sialo-N-glycans in glycoproteins as 1-phenyl-3-methyl-5-pyrazolone derivatives by capillary electrophoresis.
Topics: Antipyrine; Chromatography, High Pressure Liquid; Edaravone; Electrophoresis, Capillary; Glycoproteins; Polysaccharides | 2001 |
Capillary electrophoretic analysis of carbohydrates derivatized by in-capillary condensation with 1-phenyl-3-methyl-5-pyrazolone.
Topics: Antipyrine; Calibration; Carbohydrates; Edaravone; Electrophoresis, Capillary; Reproducibility of Results; Spectrophotometry, Ultraviolet | 2001 |
Investigation of different combinations of derivatization, separation methods and electrospray ionization mass spectrometry for standard oligosaccharides and glycans from ovalbumin.
Topics: Amidohydrolases; Animals; Antipyrine; Carbohydrate Sequence; Chickens; Chromatography, High Pressure Liquid; Edaravone; Fluorescent Dyes; Molecular Sequence Data; Naphthalenes; Oligosaccharides; Ovalbumin; Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase; Polysaccharides; Spectrometry, Mass, Electrospray Ionization | 2001 |
Determination of oligosaccharides in Pompe disease by electrospray ionization tandem mass spectrometry.
Topics: Adolescent; Adult; Antipyrine; Child; Child, Preschool; Edaravone; Glycogen Storage Disease Type II; Humans; Indicators and Reagents; Infant; Infant, Newborn; Middle Aged; Oligosaccharides; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2002 |
A study of immunoglobulin G glycosylation in monoclonal and polyclonal species by electrospray and matrix-assisted laser desorption/ionization mass spectrometry.
Topics: Animals; Antibodies; Antibodies, Monoclonal; Antipyrine; Carbohydrate Sequence; Cattle; Cell Line; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Edaravone; Electrophoresis; Glycosylation; Humans; Immunoglobulin G; Mice; Molecular Sequence Data; Oxygen; Polysaccharides; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2002 |
Combined argatroban and edaravone caused additive neuroprotection against 15 min of forebrain ischemia in gerbils.
Topics: Animals; Anticoagulants; Antipyrine; Arginine; Body Water; Brain Edema; Brain Ischemia; Cerebral Infarction; Cerebrovascular Circulation; Drug Interactions; Drug Therapy, Combination; Edaravone; Endothelium, Vascular; Free Radical Scavengers; Free Radicals; Gerbillinae; Male; Nerve Degeneration; Neuroprotective Agents; Pipecolic Acids; Prosencephalon; Reperfusion Injury; Sulfonamides | 2002 |
Effect of the free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), on hypoxia-ischemia-induced brain injury in neonatal rats.
Topics: Animals; Animals, Newborn; Antipyrine; Brain; Edaravone; Female; Free Radical Scavengers; Hypoxia-Ischemia, Brain; Oxidative Stress; Pregnancy; Rats; Rats, Wistar | 2002 |
Automated structural assignment of derivatized complex N-linked oligosaccharides from tandem mass spectra.
Topics: Algorithms; Antipyrine; Carbohydrate Sequence; Edaravone; Indicators and Reagents; Mass Spectrometry; Molecular Sequence Data; Oligosaccharides; Software | 2002 |
Myocardial protection of MCI-186 in rabbit ischemia-reperfusion.
Topics: Animals; Antipyrine; Blood Pressure; Disease Models, Animal; Edaravone; Electrocardiography; Free Radical Scavengers; Malondialdehyde; Myocardial Reperfusion Injury; Myocardium; Necrosis; Rabbits | 2002 |
Protection by a radical scavenger edaravone against cisplatin-induced nephrotoxicity in rats.
Topics: Animals; Antipyrine; Blood Urea Nitrogen; Cisplatin; Creatinine; Dose-Response Relationship, Drug; Edaravone; Free Radical Scavengers; Glutathione; Kidney; Male; Rats; Rats, Wistar | 2002 |
Edarabone scavenges nitric oxide.
Topics: Antioxidants; Antipyrine; Dose-Response Relationship, Drug; Edaravone; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Hydroxyl Radical; Nitric Oxide | 2002 |
Beneficial effect of MCI-186 on hepatic warm ischemia-reperfusion in the rat.
Topics: Animals; Antipyrine; Apoptosis; Edaravone; Free Radical Scavengers; In Situ Nick-End Labeling; Ischemia; Liver; Male; Rats; Rats, Wistar; Reactive Oxygen Species; Reperfusion Injury | 2002 |
Contractile responses to reactive oxygen species in the canine basilar artery in vitro: selective inhibitory effect of MCI-186, a new hydroxyl radical scavenger.
Topics: Animals; Antipyrine; Basilar Artery; Disease Models, Animal; Dogs; Edaravone; Female; Free Radical Scavengers; Hydrogen Peroxide; Hydroxyl Radical; In Vitro Techniques; Male; Oxidants; Reactive Oxygen Species; Superoxides; Vasospasm, Intracranial | 2002 |
Protective effect of edaravone against streptomycin-induced vestibulotoxicity in the guinea pig.
Topics: Animals; Antipyrine; Edaravone; Guinea Pigs; Male; Nystagmus, Physiologic; Protective Agents; Reflex, Vestibulo-Ocular; Streptomycin; Vestibular Diseases; Vestibular Function Tests; Vestibule, Labyrinth | 2003 |
A novel free radical scavenger, edarabone, protects against cisplatin-induced acute renal damage in vitro and in vivo.
Topics: Acute Disease; Animals; Antipyrine; Apoptosis; Cell Size; Cell Survival; Cisplatin; Edaravone; Free Radical Scavengers; Kidney Diseases; Kidney Function Tests; Lipid Metabolism; Male; Mitochondria; Nucleic Acids; Oxidation-Reduction; Rats; Rats, Wistar; Reactive Oxygen Species | 2003 |
Edaravone protects against ischemia/reperfusion-induced oxidative damage to mitochondria in rat liver.
Topics: Animals; Antipyrine; Edaravone; Electron Transport; Free Radical Scavengers; Glutathione Peroxidase; Lipid Peroxidation; Male; Microscopy, Electron; Mitochondria, Liver; Oxidative Phosphorylation; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2003 |
Protective effect of 3-methyl-1-phenyl-2-pyrazolin-5-one, a free radical scavenger, on acute toxicity of paraquat in mice.
Topics: Animals; Antipyrine; Dose-Response Relationship, Drug; Edaravone; Free Radical Scavengers; Herbicides; Male; Mice; Paraquat; Proportional Hazards Models; Survival; Time Factors | 2003 |
Efficacy of edaravone, a free radical scavenger, on left ventricular function and structure in diabetes mellitus.
Topics: Animals; Antioxidants; Antipyrine; Blood Glucose; Blotting, Western; Diabetes Mellitus, Type 2; Edaravone; Free Radical Scavengers; Immunohistochemistry; Male; Microscopy, Electron; Microscopy, Polarization; Myocardium; NADP; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Inbred OLETF; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Ventricular Function, Left | 2003 |
The free radical scavenger edaravone suppresses experimental closed duodenal loop-induced acute pancreatitis in rats.
Topics: Aldehydes; Amylases; Animals; Antipyrine; Ascitic Fluid; Edaravone; Free Radical Scavengers; Malondialdehyde; Pancreatitis, Acute Necrotizing; Rats | 2003 |
The free radical scavenger edaravone suppresses experimental dextran sulfate sodium-induced colitis in rats.
Topics: Aldehydes; Animals; Antipyrine; Colitis; Edaravone; Free Radical Scavengers; Interleukin-6; Male; Malondialdehyde; Peroxidase; Rats; Rats, Sprague-Dawley | 2003 |
Clinical usefulness of edaravone for acute liver injury.
Topics: Animals; Antipyrine; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Edaravone; Free Radical Scavengers; Liver Diseases; Liver Function Tests; Male; Rats; Rats, Wistar; Statistics, Nonparametric | 2003 |
Antioxidant MCI-186 inhibits mitochondrial permeability transition pore and upregulates Bcl-2 expression.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Antioxidants; Antipyrine; Atractyloside; Blood Pressure; Cytochromes c; DNA Fragmentation; Edaravone; Enzyme Inhibitors; Heart Rate; Indazoles; Male; Mitochondrial Swelling; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Up-Regulation | 2003 |
Determination of 1-phenyl-3-methyl-5-pyrazolone-labeled carbohydrates by liquid chromatography and micellar electrokinetic chromatography.
Topics: Antipyrine; Carbohydrates; Chromatography, High Pressure Liquid; Chromatography, Micellar Electrokinetic Capillary; Edaravone | 2003 |
[The clinical effect of combination therapy with edaravone and sodium ozagrel for acute cerebral infarction].
Topics: Aged; Antipyrine; Cerebral Infarction; Drug Therapy, Combination; Edaravone; Female; Fibrinolytic Agents; Free Radical Scavengers; Humans; Male; Methacrylates; Middle Aged; Treatment Outcome | 2003 |
Structure-activity relationship of 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone).
Topics: Animals; Antipyrine; Edaravone; Free Radical Scavengers; Male; Rats; Rats, Wistar; Structure-Activity Relationship | 2003 |
Synthesis of the metabolites of a free radical scavenger edaravone (MCI-186, Radicut).
Topics: Antipyrine; Edaravone; Free Radical Scavengers; Glucuronates; Molecular Structure; Sulfates | 2003 |
Edaravone, a novel free radical scavenger, prevents liver injury and mortality in rats administered endotoxin.
Topics: Alanine Transaminase; Animals; Antipyrine; Chemokine CCL4; Chemokines; Chemokines, CC; Chemokines, CXC; Disease Models, Animal; Edaravone; Endotoxemia; Endotoxins; Free Radical Scavengers; Gene Expression; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Interferon-gamma; Interleukin-10; Interleukin-16; Interleukin-6; Leukocytes; Lipid Peroxidation; Lipopolysaccharides; Macrophage Inflammatory Proteins; Male; Monokines; Neutrophils; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; RNA, Messenger; Tumor Necrosis Factor-alpha | 2003 |
Normalization by edaravone, a free radical scavenger, of irradiation-reduced endothelial nitric oxide synthase expression.
Topics: Acetylcholine; Animals; Antipyrine; Arteries; Blotting, Western; Ear; Edaravone; Endothelium, Vascular; Fluorescent Antibody Technique; Free Radical Scavengers; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phenylephrine; Rabbits; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Vasodilator Agents | 2003 |
Free radical scavenger protects against inner hair cell loss after cochlear ischemia.
Topics: Analysis of Variance; Animals; Antipyrine; Auditory Threshold; Cell Death; Cochlear Diseases; Edaravone; Free Radical Scavengers; Gerbillinae; Hair Cells, Auditory, Inner; Hearing Loss; Ischemia; Male; Time Factors | 2003 |
A theoretical investigation on DPPH radical-scavenging mechanism of edaravone.
Topics: Antipyrine; Biphenyl Compounds; Chemical Phenomena; Chemistry, Physical; Edaravone; Electron Transport; Free Radical Scavengers; Free Radicals; Hydrogen; Models, Molecular; Picrates; Structure-Activity Relationship; Thermodynamics; Vitamin E | 2003 |
A free radical scavenger, edaravone, attenuates steatosis and cell death via reducing inflammatory cytokine production in rat acute liver injury.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acute Disease; Alanine Transaminase; Aldehydes; Animals; Antipyrine; Apoptosis; Cell Death; Cytokines; Deoxyguanosine; Edaravone; Free Radical Scavengers; Growth Inhibitors; Immunohistochemistry; In Situ Nick-End Labeling; Interleukin-10; Interleukin-4; Interleukin-6; Liver; Male; Models, Chemical; Necrosis; Oxygen; Rats; Rats, Wistar; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Tumor Necrosis Factor-alpha | 2003 |
High-speed electrophoretic analysis of 1-phenyl-3-methyl-5-pyrazolone derivatives of monosaccharides on a quartz microchip with whole-channel UV detection.
Topics: alpha-Amylases; Antipyrine; Edaravone; Electrophoresis, Capillary; Free Radical Scavengers; Hexoses; Indicators and Reagents; Monosaccharides; Oligosaccharides; Pentoses; Reproducibility of Results | 2003 |
Edaravone, a radical scavenger, may enhance or produce antiproliferative effects of fluvastatin, amlodipine, ozagrel, GF109203X and Y27632 on cultured basilar artery smooth muscle cells.
Topics: Amides; Amlodipine; Animals; Antipyrine; Arteriosclerosis; Basilar Artery; Cell Division; Cell Survival; Cells, Cultured; Drug Synergism; Drug Therapy, Combination; Edaravone; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Fluvastatin; Free Radical Scavengers; Indoles; Maleimides; Methacrylates; Muscle, Smooth, Vascular; Pyridines; Reactive Oxygen Species; Signal Transduction; Tetrazolium Salts; Thiazoles | 2003 |
Effect of ozagrel, a selective thromboxane A2-synthetase inhibitor, on cerebral infarction in rats. Comparative study with norphenazone, a free-radical scavenger.
Topics: Animals; Antipyrine; Edaravone; Enzyme Inhibitors; Free Radical Scavengers; Infarction, Middle Cerebral Artery; Male; Methacrylates; Middle Cerebral Artery; Optic Chiasm; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Thrombosis; Thromboxane-A Synthase | 2003 |
Edaravone, a newly developed radical scavenger, protects against ischemia-reperfusion injury of the small intestine in rats.
Topics: Animals; Antipyrine; Cytokines; Edaravone; Free Radical Scavengers; Hemoglobins; Intestinal Mucosa; Intestine, Small; Rats; Reperfusion Injury | 2004 |
MCI-186 prevents spinal cord damage and affects enzyme levels of nitric oxide synthase and Cu/Zn superoxide dismutase after transient ischemia in rabbits.
Topics: Animals; Antipyrine; Biopsy, Needle; Disease Models, Animal; Edaravone; Immunohistochemistry; Injections, Intravenous; Ischemia; Male; Motor Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rabbits; Random Allocation; Reference Values; Sensitivity and Specificity; Spinal Cord Injuries; Superoxide Dismutase | 2003 |
[An improved quantitative method for evaluation of ischemic injury and neuroprotection in mouse brain slices].
Topics: Alprostadil; Animals; Antipyrine; Brain Ischemia; Edaravone; Formazans; Male; Mice; Mice, Inbred ICR; Neuroprotective Agents; Staining and Labeling; Tetrazolium Salts | 2003 |
Effects of edaravone on experimental brain injury in view of free radical reaction.
Topics: Animals; Antipyrine; Body Water; Brain; Brain Edema; Brain Injuries; Edaravone; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Male; Rats; Rats, Wistar; Reactive Oxygen Species; Wounds, Nonpenetrating | 2003 |
The reaction rate of edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186)) with hydroxyl radical.
Topics: Antipyrine; Cyclic N-Oxides; Edaravone; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Hydroxyl Radical; Oxidation-Reduction; Spin Trapping | 2004 |
The hydroxyl radical scavenger MCI-186 protects the liver from experimental cold ischaemia-reperfusion injury.
Topics: Animals; Antipyrine; Cold Temperature; Edaravone; Free Radical Scavengers; Hydroxyl Radical; Interleukin-10; Liver; Liver Diseases; Male; Organ Size; Rats; Rats, Wistar; Reperfusion Injury; RNA, Messenger; Weight Gain | 2004 |
[Alterations of antiproliferative effects of serum obtained from patients with acute cerebral infarction treated with a radical scavenger, edaravone, with or without amlodipine using an in vitro cultured basilar artery smooth muscle cells].
Topics: Acute Disease; Aged; Amlodipine; Animals; Antioxidants; Antipyrine; Basilar Artery; Calcium Channel Blockers; Cell Division; Cells, Cultured; Cerebral Infarction; Depression, Chemical; Edaravone; Female; Free Radical Scavengers; Guinea Pigs; Humans; Male; Middle Aged; Muscle, Smooth, Vascular; Serum | 2004 |
The clinical free radical scavenger, edaravone, protects cochlear hair cells from acoustic trauma.
Topics: Animals; Antipyrine; Cochlea; Drug Implants; Edaravone; Evoked Potentials, Auditory, Brain Stem; Free Radical Scavengers; Guinea Pigs; Hair Cells, Auditory; Hair Cells, Auditory, Outer; Hearing Loss, Noise-Induced; Noise; Organ of Corti | 2004 |
Inhibitory effect of free radical scavenger, MCI-186, in the increase of hydroxyl radical induced by iminodipropionitrile in rats.
Topics: Animals; Antipyrine; Brain; Edaravone; Free Radical Scavengers; Hydroxybenzoates; Hydroxyl Radical; Male; Movement Disorders; Nitriles; Rats; Rats, Wistar | 2004 |
Radical scavenger edaravone developed for clinical use ameliorates ischemia/reperfusion injury in rat kidney.
Topics: Animals; Antipyrine; Cell Line; Edaravone; Free Radical Scavengers; Humans; Kidney; Kidney Tubules, Proximal; Lipid Peroxidation; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury | 2004 |
[Effects of edaravone, minocycline and ONO-1078 on oxygen/glucose deprivation-induced electrophysiological alteration in rat hippocampal slices].
Topics: Animals; Anti-Bacterial Agents; Antipyrine; Brain Ischemia; Chromones; Edaravone; Evoked Potentials; Female; Free Radical Scavengers; Glucose; Hippocampus; Leukotriene Antagonists; Minocycline; Neuroprotective Agents; Rats; Rats, Sprague-Dawley | 2004 |
Extension of ischemic therapeutic time window by a free radical scavenger, Edaravone, reperfused with tPA in rat brain.
Topics: Aldehydes; Animals; Antipyrine; Brain Ischemia; Cell Count; Deoxyadenosines; Disease Models, Animal; Drug Administration Schedule; Drug Therapy, Combination; Edaravone; Fibrinolytic Agents; Free Radical Scavengers; Glycation End Products, Advanced; Hemorrhage; Immunohistochemistry; In Situ Nick-End Labeling; Male; Rats; Rats, Wistar; Survival Analysis; Tetrazolium Salts; Time Factors; Tissue Plasminogen Activator | 2004 |
Protective effect of edaravone against hypoxia-reoxygenation injury in rabbit cardiomyocytes.
Topics: Action Potentials; Animals; Antipyrine; Cell Death; Cells, Cultured; Edaravone; Flow Cytometry; Free Radical Scavengers; Models, Cardiovascular; Myocytes, Cardiac; Oxidative Stress; Oxygen; Rabbits; Reactive Oxygen Species; Reperfusion Injury | 2004 |
Edaravone protects against hypoxia/ischemia-induced endoplasmic reticulum dysfunction.
Topics: Animals; Antipyrine; Apoptosis; Brain Ischemia; Cells, Cultured; Edaravone; Endoplasmic Reticulum; Free Radical Scavengers; Hypoxia; Ischemia; Male; Mice; Mice, Inbred C57BL; Neuroglia; Reactive Oxygen Species; Signal Transduction; Stress, Physiological; Tunicamycin | 2004 |
Edaravone inhibits acute renal injury and cyst formation in cisplatin-treated rat kidney.
Topics: Animals; Antineoplastic Agents; Antipyrine; Apoptosis; Body Weight; Cisplatin; DNA; DNA, Mitochondrial; Edaravone; Free Radical Scavengers; Free Radicals; Kidney; Kidney Diseases; Male; Mitochondria; Oxygen Consumption; Rats; Rats, Wistar; Time Factors | 2004 |
Antioxidant effect of MCI-186, a new Free-Radical scavenger, on ischemia-reperfusion injury in a rat hindlimb amputation model.
Topics: Amputation, Surgical; Animals; Antioxidants; Antipyrine; Body Water; Edaravone; Enzymes; Free Radical Scavengers; Hindlimb; Lipid Peroxidation; Male; Muscle, Skeletal; Peroxidase; Rats; Rats, Inbred Lew; Reperfusion Injury | 2004 |
Neuroprotection of edaravone on hypoxic-ischemic brain injury in neonatal rats.
Topics: Animals; Animals, Newborn; Antipyrine; Blotting, Western; Brain; Caspase 3; Caspases; Cell Count; Cell Death; Cytochromes c; DNA Fragmentation; Edaravone; Hypoxia-Ischemia, Brain; In Situ Nick-End Labeling; Neurons; Neuroprotective Agents; Rats; Time Factors | 2004 |
MCI-186 reduces oxidative cellular damage and increases DNA repair function in the rabbit spinal cord after transient ischemia.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antipyrine; Apoptosis; Ataxia; Biomarkers; Cell Count; Cell Nucleus; Deoxyguanosine; DNA Damage; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; Edaravone; Free Radical Scavengers; Ischemia; Male; Models, Animal; Motor Neurons; Nerve Tissue Proteins; Oxidation-Reduction; Oxidative Stress; Paraplegia; Postoperative Complications; Rabbits; Spinal Cord | 2004 |
In vivo radioprotection of mice by 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone; Radicut), a clinical drug.
Topics: Animals; Antipyrine; Body Temperature; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Edaravone; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C3H; Pharmaceutical Preparations; Radiation Injuries; Radiation Protection; Radiation Tolerance; Radiation-Protective Agents; Survival; Survival Analysis; Treatment Outcome; Whole-Body Irradiation; X-Rays | 2004 |
Montelukast, a cysteinyl leukotriene receptor-1 antagonist, dose- and time-dependently protects against focal cerebral ischemia in mice.
Topics: Acetates; Animals; Antipyrine; Blood-Brain Barrier; Brain; Brain Edema; Brain Ischemia; Chromones; Cyclopropanes; Dose-Response Relationship, Drug; Edaravone; Free Radical Scavengers; Infarction, Middle Cerebral Artery; Leukotriene Antagonists; Mice; Nervous System; Neuroprotective Agents; Psychomotor Performance; Quinolines; Receptors, Leukotriene; Sulfides; Survival Analysis; Time Factors | 2005 |
A newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats.
Topics: Animals; Antipyrine; Brain; Brain Ischemia; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Cerebral Infarction; Dose-Response Relationship, Drug; Edaravone; Enzyme Inhibitors; Fluorescent Antibody Technique; Free Radical Scavengers; Glyceraldehyde-3-Phosphate Dehydrogenases; Neuroprotective Agents; Poly(ADP-ribose) Polymerase Inhibitors; Pyrimidinones; Rats; Rats, Wistar; Reactive Oxygen Species; Substrate Specificity; Time Factors | 2005 |
Effect of edaravone on streptomycin-induced vestibulotoxicity in the Guinea pig.
Topics: Administration, Topical; Animals; Antipyrine; Ear, Inner; Edaravone; Electronystagmography; Free Radical Scavengers; Guinea Pigs; Injections, Intraperitoneal; Male; Postural Balance; Streptomycin; Vestibule, Labyrinth | 2004 |
Effect of edaravone, a novel free radical scavenger, on endothelium-dependent vasodilation in smokers.
Topics: Acetylcholine; Adult; Antipyrine; Edaravone; Endothelium, Vascular; Free Radical Scavengers; Humans; Male; Nitroprusside; omega-N-Methylarginine; Smoking; Vasodilation | 2004 |
Pretreatment with the free radical scavenger edaravone prevents cerebral hyperperfusion after carotid endarterectomy.
Topics: Aged; Antipyrine; Brain; Carotid Artery, Internal; Carotid Stenosis; Cerebral Arterial Diseases; Cerebrovascular Circulation; Combined Modality Therapy; Edaravone; Endarterectomy, Carotid; Female; Free Radical Scavengers; Humans; Male; Middle Aged; Perfusion; Syndrome | 2004 |
Neuroprotective effects of the free radical scavenger Edaravone (MCI-186) in mice permanent focal brain ischemia.
Topics: Animals; Antipyrine; Brain Ischemia; DNA-Binding Proteins; Edaravone; Ethidium; Free Radical Scavengers; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Inbred BALB C; Nerve Tissue Proteins; Neuroprotective Agents; Nuclear Proteins; Reactive Oxygen Species; Superoxides | 2004 |
EPR imaging to estimate the in vivo intracerebral reducing ability of mature rats after neonatal hypoxic-ischemic brain injury.
Topics: Animals; Animals, Newborn; Antipyrine; Blood-Brain Barrier; Brain; Carotid Artery, Common; Cyclic N-Oxides; Disease Models, Animal; Edaravone; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Hypoxia-Ischemia, Brain; Ligation; Neuroprotective Agents; Oxidation-Reduction; Pyrrolidines; Rats; Rats, Wistar | 2004 |
Free radical scavenger (edaravone) prevents endotoxin-induced liver injury after partial hepatectomy in rats.
Topics: Alanine Transaminase; Animals; Antipyrine; Bilirubin; Cytokines; Edaravone; Free Radical Scavengers; L-Lactate Dehydrogenase; Lipopolysaccharides; Liver; Male; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley | 2005 |
Edaravone protects against lung injury induced by intestinal ischemia/reperfusion in rat.
Topics: Animals; Antipyrine; Disease Progression; Edaravone; Interleukin-6; Intestines; Ischemia; Lung; Male; Malondialdehyde; Neutrophil Infiltration; Rats; Rats, Wistar; Reperfusion Injury; Respiratory Distress Syndrome; RNA, Messenger; Survival Analysis | 2005 |
[A case of common carotid artery dissection showing remission in short-term].
Topics: Antipyrine; Aortic Dissection; Aspirin; Carotid Artery Diseases; Carotid Artery, Common; Drug Therapy, Combination; Edaravone; Humans; Infarction, Middle Cerebral Artery; Magnetic Resonance Imaging; Male; Middle Aged; Remission Induction; Ultrasonography, Interventional | 2005 |
The radical scavenger edaravone prevents oxidative neurotoxicity induced by peroxynitrite and activated microglia.
Topics: Animals; Antipyrine; Cells, Cultured; Dose-Response Relationship, Drug; Edaravone; Free Radical Scavengers; Mice; Mice, Inbred C57BL; Microglia; Neuroprotective Agents; Oxidative Stress; Peroxynitrous Acid | 2005 |
Intrathecal edaravone, a free radical scavenger, is effective on inflammatory-induced pain in rats.
Topics: Animals; Antipyrine; Behavior, Animal; Disease Models, Animal; Disinfectants; Dose-Response Relationship, Drug; Edaravone; Formaldehyde; Free Radical Scavengers; Hot Temperature; Inflammation; Injections, Spinal; Male; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reaction Time; Time Factors | 2005 |
Edaravone, a novel radical scavenger, inhibits oxidative modification of low-density lipoprotein (LDL) and reverses oxidized LDL-mediated reduction in the expression of endothelial nitric oxide synthase.
Topics: Animals; Antioxidants; Antipyrine; Blood Proteins; Copper; Edaravone; Free Radical Scavengers; Injections, Intravenous; Lipoproteins, LDL; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidation-Reduction; Rats; Rats, Wistar; RNA Stability; RNA, Messenger | 2005 |
Effects of edaravone on human neutrophil function.
Topics: Antipyrine; Calcium; Chemotaxis; Dose-Response Relationship, Drug; Edaravone; Free Radical Scavengers; Humans; Hydrogen Peroxide; Hydroxyl Radical; In Vitro Techniques; Neutrophils; Phagocytosis; Reactive Oxygen Species; Reference Values; Xanthine; Xanthine Oxidase | 2005 |
ONO-1078 reduces NMDA-induced brain injury and vascular cell adhesion molecule-1 expression in rats.
Topics: Animals; Antipyrine; Brain; Brain Injuries; Cerebral Cortex; Chromones; Edaravone; Leukotriene Antagonists; Male; Microinjections; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Vascular Cell Adhesion Molecule-1 | 2005 |
High performance liquid chromatographic determination of N-butyryl glucosamine in rat plasma.
Topics: Administration, Oral; Animals; Antipyrine; Chromatography, High Pressure Liquid; Edaravone; Glucosamine; Male; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity | 2005 |
The antioxidant edaravone attenuates pressure overload-induced left ventricular hypertrophy.
Topics: Animals; Antioxidants; Antipyrine; Edaravone; Enzyme Activation; Free Radical Scavengers; Hypertension; Hypertrophy, Left Ventricular; Male; MAP Kinase Kinase Kinase 5; Mice; Mice, Inbred C57BL; Myocardium; Oxidative Stress | 2005 |
Temporal effects of edaravone, a free radical scavenger, on transient ischemia-induced neuronal dysfunction in the rat hippocampus.
Topics: Animals; Antipyrine; Blotting, Western; Brain Ischemia; Edaravone; Fibroblast Growth Factor 2; Fluorescent Antibody Technique; Free Radical Scavengers; Hippocampus; Hydroxyl Radical; Long-Term Potentiation; Male; Microscopy, Confocal; Nitric Oxide Synthase; Perforant Pathway; Rats; Rats, Wistar; Time Factors; Vascular Endothelial Growth Factor A | 2005 |
Influence of the labeling group on ionization and fragmentation of carbohydrates in mass spectrometry.
Topics: Antipyrine; Benzamides; Carbohydrates; Edaravone; Hydrazones; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Staining and Labeling | 2005 |
A free radical scavenger, edaravone (MCI-186), diminishes intestinal neutrophil lipid peroxidation and bacterial translocation in a rat hemorrhagic shock model.
Topics: Animals; Antipyrine; Bacterial Translocation; Edaravone; Free Radical Scavengers; Ileum; Lipid Peroxidation; Lymph Nodes; Male; Neutrophils; Rats; Rats, Sprague-Dawley; Shock, Hemorrhagic | 2005 |
Bacterial translocation in hemorrhagic shock: Are we any wiser?
Topics: Animals; Antipyrine; Bacterial Translocation; Edaravone; Free Radical Scavengers; Lipid Peroxidation; Rats; Shock, Hemorrhagic | 2005 |
Bacterial translocation and intestinal neutrophil lipid peroxidation in a hemorrhagic shock model--Rat race or rat trap?
Topics: Animals; Antipyrine; Bacterial Translocation; Edaravone; Free Radical Scavengers; Humans; Lipid Peroxidation; Neutrophils; Oxidative Stress; Rats; Shock, Hemorrhagic | 2005 |
Neuroprotection and enhanced recovery with edaravone after acute spinal cord injury in rats.
Topics: Acute Disease; Animals; Antipyrine; Edaravone; Free Radical Scavengers; Hindlimb; Injections, Intravenous; Lipid Peroxidation; Male; Motor Activity; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Recovery of Function; Spinal Cord; Spinal Cord Injuries; Thiobarbituric Acid Reactive Substances; Time Factors | 2005 |
Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in rats.
Topics: Animals; Antipyrine; Apoptosis; bcl-2-Associated X Protein; Brain Edema; Brain Ischemia; Cerebral Cortex; Cerebral Infarction; Cerebrovascular Circulation; Edaravone; Immunohistochemistry; In Situ Nick-End Labeling; Male; Neuroprotective Agents; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2005 |
Maternal treatment with MCI-186 does not improve delayed deterioration of cellular bioenergetic state and mitochondrial activity following transient intrauterine ischemia in the fetal rat brain.
Topics: Animals; Antipyrine; Brain; Brain Ischemia; Edaravone; Energy Metabolism; Female; Fetal Hypoxia; Free Radical Scavengers; Mitochondria; Pregnancy; Rats; Rats, Wistar; Reperfusion Injury | 2005 |
MCI-186 (edaravone), a free radical scavenger, attenuates hepatic warm ischemia-reperfusion injury in rats.
Topics: Alanine Transaminase; Aldehydes; Animals; Antipyrine; Chemokines; Cytokines; Edaravone; Free Radical Scavengers; Immunohistochemistry; Liver; Macrophages; Male; Rats; Rats, Wistar; Reperfusion Injury; RNA, Messenger; Time Factors | 2005 |
Dielectric relaxation spectroscopy of heteronuclear cobalt(II)-copper(II) complex of 1-phenyl-3-methyl-5-pyrazolone.
Topics: Antipyrine; Cobalt; Copper; Edaravone; Electrochemistry; Models, Chemical; Spectrum Analysis; Temperature | 2005 |
Edaravone prevented deteriorated cardiac function after myocardial ischemia-reperfusion via inhibiting lipid peroxidation in rat.
Topics: Animals; Antipyrine; Edaravone; Free Radical Scavengers; Heart; Lipid Peroxidation; Male; Malondialdehyde; Myocardial Contraction; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley; Tachycardia, Ventricular; Ventricular Pressure | 2005 |
Lack of antiapoptotic effects of antiplatelet drug, aspirin and clopidogrel, and antioxidant, MCI-186, against focal ischemic brain damage in rats.
Topics: Animals; Antioxidants; Antipyrine; Aspirin; bcl-2-Associated X Protein; Blotting, Western; Brain Edema; Brain Ischemia; Cerebral Infarction; Clopidogrel; Cyclic AMP Response Element-Binding Protein; Disability Evaluation; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Administration Routes; Edaravone; Functional Laterality; Gene Expression Regulation; Hypoxia, Brain; Male; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; PTEN Phosphohydrolase; Rats; Rats, Sprague-Dawley; Ticlopidine; Tumor Suppressor Proteins | 2005 |
Attenuation of extravasation of tissue plasminogen activator by the free radical scavenger, edaravone: evaluation in a rat thromboembolic stroke model.
Topics: Analysis of Variance; Animals; Antipyrine; Blood Vessels; Cerebral Hemorrhage; Disease Models, Animal; Drug Interactions; Edaravone; Enzyme-Linked Immunosorbent Assay; Free Radical Scavengers; Laser-Doppler Flowmetry; Male; Rats; Rats, Sprague-Dawley; Stroke; Time Factors; Tissue Plasminogen Activator | 2005 |
[A case of stroke-like episode of MELAS of which progressive spread would be prevented by edaravone].
Topics: Adult; Antipyrine; Brain; Disease Progression; Edaravone; Female; Free Radical Scavengers; Humans; Magnetic Resonance Imaging; MELAS Syndrome | 2005 |
Antioxidant properties of minocycline: neuroprotection in an oxidative stress assay and direct radical-scavenging activity.
Topics: Animals; Antioxidants; Antipyrine; Benzothiazoles; Cell Death; Cells, Cultured; Cerebral Cortex; Chromans; Deoxyribose; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Edaravone; Embryo, Mammalian; Free Radical Scavengers; Free Radicals; Glutamic Acid; Inhibitory Concentration 50; L-Lactate Dehydrogenase; Lipid Peroxidation; Minocycline; Neurons; Neuroprotective Agents; Oxidative Stress; Phenethylamines; Rats; Rats, Sprague-Dawley; Sulfonic Acids; Vitamin E | 2005 |
Efficacy of edaravone, a free radical scavenger, for the treatment of acute lacunar infarction.
Topics: Acute Disease; Aged; Antipyrine; Brain Infarction; Edaravone; Female; Free Radical Scavengers; Humans; Male; Retrospective Studies; Treatment Outcome | 2005 |
A radical scavenger, edaravone, protects canine kidneys from ischemia-reperfusion injury after 72 hours of cold preservation and autotransplantation.
Topics: Animals; Antipyrine; Dogs; Edaravone; Female; Free Radical Scavengers; Kidney; Kidney Function Tests; Kidney Transplantation; Malondialdehyde; Organ Preservation; P-Selectin; Reperfusion Injury; Transplantation, Autologous | 2005 |
Effect of a novel free radical scavenger, edaravone, on puromycin aminonucleoside induced nephrosis in rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antipyrine; Biomarkers; Deoxyguanosine; DNA Damage; Edaravone; Female; Free Radical Scavengers; Nephrosis; Oxidation-Reduction; Proteinuria; Puromycin Aminonucleoside; Rats; Rats, Inbred WKY; Time Factors | 2005 |
The radical scavenger edaravone enhances the anti-tumor effects of CPT-11 in murine colon cancer by increasing apoptosis via inhibition of NF-kappaB.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antipyrine; Apoptosis; Blotting, Western; Camptothecin; Caspase 3; Caspases; Cell Line, Tumor; Colonic Neoplasms; Disease Models, Animal; Edaravone; Electrophoretic Mobility Shift Assay; Free Radical Scavengers; In Situ Nick-End Labeling; Irinotecan; Lung Neoplasms; Male; Mice; NF-kappa B; Reactive Oxygen Species | 2005 |
MCI-186 (edaravone), a novel free radical scavenger, protects against acute autoimmune myocarditis in rats.
Topics: Acute Disease; Animals; Antipyrine; Autoimmune Diseases; Cardiotonic Agents; Cytokines; Dose-Response Relationship, Drug; Edaravone; Free Radical Scavengers; Myocarditis; Rats; Rats, Inbred Lew; Treatment Outcome | 2005 |
Effect of the free radical scavenger MCI-186 on spinal cord reperfusion after transient ischemia in the rabbit.
Topics: Animals; Antipyrine; Cell Death; Dose-Response Relationship, Drug; Edaravone; Free Radical Scavengers; Ischemia; Male; Models, Animal; Neurons; Rabbits; Reperfusion; Reperfusion Injury; Spinal Cord | 2005 |
Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Anti-Inflammatory Agents; Antioxidants; Antipyrine; Brain; Brain Ischemia; Deoxyguanosine; DNA Damage; Edaravone; Electrophoresis, Polyacrylamide Gel; Free Radical Scavengers; Immunoblotting; Immunohistochemistry; Inflammation; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Oxidative Stress; Reperfusion Injury; Time Factors; Tyrosine | 2005 |
Post-exposure administration of edaravone attenuates noise-induced hearing loss.
Topics: Aldehydes; Animals; Antipyrine; Auditory Threshold; Brain Stem; Cell Count; Edaravone; Free Radical Scavengers; Guinea Pigs; Hair Cells, Auditory, Outer; Hearing Loss; Immunohistochemistry; Male; Noise; Organ of Corti; Phytotherapy | 2005 |
Short-term administration of a new free radical scavenger, edaravone, is more effective than its long-term administration for the treatment of neonatal hypoxic-ischemic encephalopathy.
Topics: Animals; Animals, Newborn; Antipyrine; Behavior, Animal; Brain; Brain Ischemia; Drug Administration Schedule; Edaravone; Free Radical Scavengers; Hypoxia-Ischemia, Brain; Maze Learning; Models, Statistical; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar; Time Factors | 2005 |
Edaravone protects against ischemia/reperfusion-induced functional and biochemical changes in rat urinary bladder.
Topics: Animals; Antipyrine; Edaravone; Free Radical Scavengers; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Urinary Bladder | 2005 |
A free radical scavenger, edaravone, inhibits lipid peroxidation and the production of nitric oxide in hypoxic-ischemic brain damage of neonatal rats.
Topics: Animals; Animals, Newborn; Antipyrine; Brain Chemistry; Edaravone; Hypoxia-Ischemia, Brain; Lipid Peroxidation; Nitric Oxide; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances | 2005 |
Analysis of the monosaccharide components in Angelica polysaccharides by high performance liquid chromatography.
Topics: Angelica sinensis; Antipyrine; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Edaravone; Monosaccharides; Plant Roots | 2005 |
Protective effect of a radical scavenger, MCI-186 on islet cell damages induced by oxidative stress.
Topics: Animals; Antipyrine; Edaravone; Free Radical Scavengers; Hydrogen Peroxide; Islets of Langerhans; Oxidative Stress; Rats; Rats, Sprague-Dawley | 2005 |
A free radical scavenger but not FGF-2-mediated angiogenic therapy rescues myonephropathic metabolic syndrome in severe hindlimb ischemia.
Topics: Angiogenesis Inducing Agents; Animals; Antipyrine; Edaravone; Fibroblast Growth Factor 2; Free Radical Scavengers; Gene Transfer Techniques; Hindlimb; Male; Metabolic Syndrome; Nephrosis; Rats; Rats, Wistar; Reperfusion Injury; Rhabdomyolysis; Severity of Illness Index; Treatment Outcome | 2006 |
Experimental study on the protective effects of edaravone against ischemic spinal cord injury.
Topics: Animals; Antipyrine; Edaravone; Free Radical Scavengers; Male; Rabbits; Reperfusion Injury; Spinal Cord Ischemia | 2005 |
Protective effect of edaravone against the ototoxicity of Pseudomonas aeruginosa exotoxin A.
Topics: ADP Ribose Transferases; Animals; Antipyrine; Audiometry, Evoked Response; Auditory Threshold; Bacterial Toxins; Ear, Middle; Edaravone; Exotoxins; Free Radical Scavengers; Hearing Loss, Sensorineural; Injections, Intravenous; Male; Pseudomonas aeruginosa Exotoxin A; Random Allocation; Rats; Rats, Sprague-Dawley; Tympanic Membrane; Virulence Factors | 2006 |
[Bilateral multiple border zone infarctions after massive bleeding: report of two cases].
Topics: Aged; Anticoagulants; Antipyrine; Brain Infarction; Diffusion Magnetic Resonance Imaging; Edaravone; Female; Hemoglobins; Heparin; Humans; Male; Menorrhagia; Middle Aged; Peptic Ulcer Hemorrhage; Stomach Ulcer | 2005 |
Correction of defective interdomain interaction within ryanodine receptor by antioxidant is a new therapeutic strategy against heart failure.
Topics: Animals; Antioxidants; Antipyrine; Calcium; Cardiac Pacing, Artificial; Dogs; Edaravone; Heart Failure; Heart Ventricles; Muscle Cells; Nitric Oxide Donors; Oxidative Stress; Protein Structure, Tertiary; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Tacrolimus Binding Protein 1A; Treatment Outcome; Ventricular Remodeling | 2005 |
The role of edaravone on the impairment of endothelial barrier function induced by acute oxidative stress in cultured human umbilical vein endothelial cell monolayer.
Topics: Analysis of Variance; Antipyrine; Capillary Permeability; Cells, Cultured; Edaravone; Electric Impedance; Endothelium, Vascular; Free Radical Scavengers; Humans; Hydrogen Peroxide; Oxidative Stress; Umbilical Veins | 2005 |
Edaravone inhibits rheumatoid synovial cell proliferation and migration.
Topics: Aged; Antipyrine; Arthritis, Rheumatoid; Cell Movement; Cell Proliferation; Edaravone; Female; Free Radical Scavengers; Humans; Interleukin-1; Synovial Membrane | 2006 |
The free radical scavengers edaravone and tempol suppress experimental dextran sulfate sodium-induced colitis in mice.
Topics: Animals; Antipyrine; Colitis; Cyclic N-Oxides; Dextran Sulfate; Disease Models, Animal; Edaravone; Free Radical Scavengers; Interleukin-6; Male; Mice; Mice, Inbred BALB C; Peroxidase; Spin Labels | 2006 |
MCI-186 (edaravone), a free radical scavenger, attenuates ischemia-reperfusion injury and activation of phospholipase A(2) in an isolated rat lung model after 18 h of cold preservation.
Topics: Animals; Antipyrine; Bronchoalveolar Lavage Fluid; Cold Ischemia; Disease Models, Animal; Edaravone; Edema; Enzyme Activation; Free Radical Scavengers; Lipid Peroxidation; Lung; Male; Organ Culture Techniques; Organ Preservation; Oxidative Stress; Oxygen; Phospholipases A; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2006 |
The production of hydroxyl radicals in the fetal lamb brain resulting from occlusion of the umbilical circulation and the transplacental effect of MCI-186 to inhibit hydroxyl radical production.
Topics: Animals; Antipyrine; Brain; Catechols; Edaravone; Female; Free Radical Scavengers; Hydroxybenzoates; Hydroxyl Radical; Maternal-Fetal Exchange; Pregnancy; Regional Blood Flow; Sheep; Umbilical Cord | 2006 |
Edaravone diminishes free radicals from circulating neutrophils in patients with ischemic brain attack.
Topics: Aged; Aged, 80 and over; Antipyrine; Brain Ischemia; Edaravone; Female; Free Radical Scavengers; Free Radicals; Humans; Male; Middle Aged; Neutrophils; Oxidative Stress | 2006 |
Reactive oxygen species generated by mitochondrial injury in human brain microvessel endothelial cells.
Topics: Antipyrine; Brain; Brain Ischemia; Cerebrovascular Circulation; Edaravone; Endothelium, Vascular; Free Radical Scavengers; Humans; Hypoxia; Microcirculation; Mitochondria; Reactive Oxygen Species; Uncoupling Agents | 2006 |
Edaravone attenuates hydroxyl radical stress and augmented angiotensin II response in diabetic rats.
Topics: Angiotensin II; Animals; Antipyrine; Aorta, Thoracic; Blood Pressure; Catalase; Diabetes Mellitus, Experimental; Edaravone; Free Radical Scavengers; Hydrogen Peroxide; Hydroxyl Radical; In Vitro Techniques; Lipid Peroxidation; Male; Malondialdehyde; Oxidative Stress; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; tert-Butylhydroperoxide; Vasoconstriction | 2006 |
Inhibitory effects of edaravone on the production of tumor necrosis factor-alpha in the isolated heart undergoing ischemia and reperfusion.
Topics: Analysis of Variance; Animals; Antipyrine; Blood Pressure; Blotting, Western; Edaravone; Free Radical Scavengers; Heart Rate; Immunoenzyme Techniques; Male; Myocardial Infarction; Myocardial Reperfusion Injury; P-Selectin; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; Ventricular Remodeling | 2006 |
An antioxidant treatment potentially protects myocardial energy metabolism by regulating uncoupling protein 2 expression in a chronic beta-adrenergic stimulation rat model.
Topics: Adrenergic beta-Agonists; Animals; Antioxidants; Antipyrine; Cardiotonic Agents; Edaravone; Energy Metabolism; Hemodynamics; Ion Channels; Lipid Peroxidation; Male; Membrane Transport Proteins; Mitochondria, Heart; Mitochondrial Proteins; Myocardium; Organ Size; Oxidative Stress; Rats; Rats, Sprague-Dawley; Uncoupling Protein 2 | 2006 |
Edaravone inhibits JNK-c-Jun pathway and restores anti-oxidative defense after ischemia-reperfusion injury in aged rats.
Topics: Aging; Animals; Antioxidants; Antipyrine; Blotting, Western; Brain; Cerebral Infarction; Edaravone; Genes, jun; Glutathione Peroxidase; Immunohistochemistry; In Situ Nick-End Labeling; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinases; Nerve Tissue Proteins; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction | 2006 |
Edaravone in acute ischemic stroke.
Topics: Antipyrine; Brain Ischemia; Edaravone; Fibrinolytic Agents; Free Radical Scavengers; Tissue Plasminogen Activator | 2006 |
Efficacy of edaravone in cardioembolic stroke.
Topics: Aged; Antipyrine; Brain Ischemia; Creatinine; Edaravone; Female; Free Radical Scavengers; Humans; Infusions, Intravenous; Male; Retrospective Studies; Risk Factors; Treatment Outcome | 2006 |
[Homeostatic conditions affect the protective effect of edaravone on ischemic injury in neurons].
Topics: Animals; Animals, Newborn; Antipyrine; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Edaravone; Glycine; Homeostasis; Hydrogen-Ion Concentration; Magnesium; Neurons; Neuroprotective Agents; Rats; Reperfusion Injury | 2006 |
Edaravone inhibits the disease activity in rheumatoid arthritis.
Topics: Antipyrine; Arthritis, Rheumatoid; C-Reactive Protein; Edaravone; Free Radical Scavengers; Humans; Male; Middle Aged; Stroke | 2006 |
Apoptosis in ischemic spinal cord injury.
Topics: Animals; Antipyrine; Apoptosis; Disease Models, Animal; Edaravone; Free Radical Scavengers; Humans; Rabbits; Reactive Oxygen Species; Spinal Cord Ischemia | 2006 |
The free-radical scavenger, edaravone, augments NO release from vascular cells and platelets after laser-induced, acute endothelial injury in vivo.
Topics: Animals; Antipyrine; Edaravone; Electrochemistry; Endothelium, Vascular; Fluorescein; Free Radical Scavengers; Image Processing, Computer-Assisted; Indicators and Reagents; Lasers; Mesenteric Veins; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Nitric Oxide; Oxidative Stress; Rats; Rats, Wistar; Thrombosis; Vascular Diseases; Venous Thrombosis | 2006 |
New modalities for the treatment of acute cardioembolic stroke.
Topics: Antipyrine; Avulavirus; Edaravone; Free Radical Scavengers; Humans; Intracranial Embolism; Neuroprotective Agents; Thrombolytic Therapy; Tissue Plasminogen Activator | 2006 |
Electron spin resonance and spin trapping technique provide direct evidence that edaravone prevents acute ischemia-reperfusion injury of the liver by limiting free radical-mediated tissue damage.
Topics: Acute Disease; Animals; Antipyrine; Edaravone; Electron Spin Resonance Spectroscopy; Free Radicals; Inflammation; Intercellular Adhesion Molecule-1; Liver; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Spin Trapping; Tumor Necrosis Factor-alpha | 2006 |
Protective effect of the radical scavenger edaravone against methamphetamine-induced dopaminergic neurotoxicity in mouse striatum.
Topics: Animals; Antipyrine; Astrocytes; Body Temperature; Cell Count; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Edaravone; Extracellular Space; Free Radical Scavengers; Glial Fibrillary Acidic Protein; Male; Methamphetamine; Mice; Microglia; Neurons; Norepinephrine; Peroxynitrous Acid; Rectum; Serotonin | 2006 |
Potent free radical scavenger, edaravone, suppresses oxidative stress-induced endothelial damage and early atherosclerosis.
Topics: Aldehydes; Animals; Antipyrine; Apolipoproteins E; Apoptosis; Atherosclerosis; Cells, Cultured; Cholesterol, Dietary; Dinoprost; Disease Models, Animal; Dose-Response Relationship, Drug; Edaravone; Endothelial Cells; Free Radical Scavengers; Hydrogen Peroxide; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidants; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Time Factors; Tyrosine; Vascular Cell Adhesion Molecule-1 | 2007 |
Protective effect of edaravone in inner-ear barotrauma in guinea pigs.
Topics: Animals; Antipyrine; Auditory Threshold; Barotrauma; Ear, Inner; Edaravone; Evoked Potentials, Auditory, Brain Stem; Free Radical Scavengers; Guinea Pigs; Injections, Intraperitoneal; Pressure; Treatment Outcome | 2006 |
Susceptibility of brain microvascular endothelial cells to advanced glycation end products-induced tissue factor upregulation is associated with intracellular reactive oxygen species.
Topics: Animals; Antipyrine; Aorta; Brain; Cattle; Cell Line; Cerebral Arterial Diseases; Cerebral Arteries; Dementia, Vascular; Diabetes Complications; Edaravone; Endothelial Cells; Free Radical Scavengers; Glycation End Products, Advanced; Intracellular Fluid; Microcirculation; Reactive Oxygen Species; RNA, Messenger; Thromboplastin; Up-Regulation | 2006 |
MCI-186 (3-methyl-1-phenyl-2-pyrazolin-5-one) attenuated simulated ischemia/reperfusion injury in cultured rat hippocampal cells.
Topics: Animals; Antipyrine; Apoptosis; Calcium; Cells, Cultured; Edaravone; Hippocampus; Malondialdehyde; Membrane Potentials; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2006 |
Effect of the free radical scavenger MCI-186 on pulmonary ischemia-reperfusion injury in dogs.
Topics: Animals; Antipyrine; Dogs; Edaravone; Free Radical Scavengers; Lung; Lung Transplantation; Reperfusion Injury | 2006 |
Voltage-dependent sodium channels in spinal cord motor neurons display rapid recovery from fast inactivation in a mouse model of amyotrophic lateral sclerosis.
Topics: Algorithms; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Animals; Antipyrine; Cells, Cultured; Data Interpretation, Statistical; Edaravone; Electrophysiology; Free Radical Scavengers; Immunohistochemistry; Kinetics; Mice; Mice, Transgenic; Motor Neurons; Mutation; Patch-Clamp Techniques; Sodium Channels; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1 | 2006 |
Edaravone protects PC12 cells from ischemic-like injury via attenuating the damage to mitochondria.
Topics: Animals; Antipyrine; Apoptosis; bcl-2-Associated X Protein; Edaravone; Flow Cytometry; Ischemia; Microscopy, Electron; Mitochondria; Neuroprotective Agents; PC12 Cells; Proto-Oncogene Proteins c-bcl-2; Rats | 2006 |
Effects of MCI-186 (edaravone), a novel free radical scavenger, upon experimental atherosclerosis in apolipoprotein E-deficient mice.
Topics: Animals; Antipyrine; Apolipoproteins E; Atherosclerosis; CD4-Positive T-Lymphocytes; Edaravone; Free Radical Scavengers; Mice; Mice, Knockout; Oxidative Stress; Time Factors | 2006 |
Effects of edaravone on N-methyl-D-aspartate (NMDA)-mediated cytochrome c release and apoptosis in neonatal rat cerebrocortical slices.
Topics: Animals; Animals, Newborn; Antipyrine; Apoptosis; Cerebral Cortex; Cytochromes c; Edaravone; Free Radical Scavengers; Humans; In Situ Nick-End Labeling; N-Methylaspartate; Rats; Rats, Sprague-Dawley | 2006 |
Treatment with edaravone improves the survival rate in renal warm ischemia-reperfusion injury using rat model.
Topics: Animals; Antipyrine; Disease Models, Animal; Edaravone; Free Radical Scavengers; Male; Rats; Rats, Inbred Lew; Renal Circulation; Reperfusion Injury; Survival Analysis | 2006 |
Hydroxyl radical scavenging by edaravone derivatives: Efficient scavenging by 3-methyl-1-(pyridin-2-yl)-5-pyrazolone with an intramolecular base.
Topics: Antipyrine; Edaravone; Free Radical Scavengers; Hydroxyl Radical; Molecular Structure; Oxidation-Reduction; Pyrazolones; Pyridines | 2006 |
Apoptosis-inducing factor is a major contributor to neuronal loss induced by neonatal cerebral hypoxia-ischemia.
Topics: Amino Acid Chloromethyl Ketones; Animals; Animals, Newborn; Antipyrine; Apoptosis; Apoptosis Inducing Factor; Caspase Inhibitors; Caspases; Cytochromes c; Edaravone; Female; Free Radical Scavengers; Hypoxia-Ischemia, Brain; Male; Mice; Mice, Mutant Strains; Mitochondria; Necrosis; Neurons; Oxidative Stress; Quinolines | 2007 |
Edaravone reduces myocardial infarct size and improves cardiac function and remodelling in rabbits.
Topics: Animals; Antipyrine; Blood Pressure; Edaravone; Enzyme Inhibitors; Free Radical Scavengers; Gentisates; Heart Rate; Hydroxybenzoates; Myocardial Infarction; Myocardial Reperfusion Injury; NG-Nitroarginine Methyl Ester; Rabbits; Superoxides; Ventricular Remodeling | 2006 |
The therapeutic efficacy of edaravone in extensively burned rats.
Topics: Animals; Antipyrine; Burns; Disease Models, Animal; Edaravone; Free Radical Scavengers; Free Radicals; Lung; Male; Malondialdehyde; Prospective Studies; Random Allocation; Rats; Rats, Wistar; Xanthine Oxidase | 2006 |
Edaravone reduces ischemia-reperfusion injury mediators in rat liver.
Topics: Animals; Antipyrine; Aspartate Aminotransferases; E-Selectin; Edaravone; Free Radical Scavengers; Lipid Peroxidation; Liver; Liver Diseases; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reperfusion Injury; RNA, Messenger; Thiobarbituric Acid Reactive Substances; Tumor Necrosis Factor-alpha | 2007 |
Anterior and posterior inferior cerebellar artery infarction with sudden deafness and vertigo.
Topics: Acute Disease; Antipyrine; Aspirin; Basilar Artery; Brain Infarction; Cerebellar Diseases; Cerebellum; Cochlear Nerve; Deafness; Early Diagnosis; Edaravone; Free Radical Scavengers; Humans; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Male; Middle Aged; Platelet Aggregation Inhibitors; Predictive Value of Tests; Time Factors; Vertebral Artery; Vertigo; Vestibular Nerve | 2006 |
Chiral resolution of monosaccharides as 1-phenyl-3-methyl-5-pyrazolone derivatives by ligand-exchange CE using borate anion as a central ion of the chiral selector.
Topics: Anions; Antipyrine; Borates; Buffers; Edaravone; Electrophoresis, Capillary; Ligands; Monosaccharides; Stereoisomerism | 2006 |
[Electron spin resonance method and brain diseases].
Topics: Animals; Antipyrine; Brain Diseases; Edaravone; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Free Radicals; Humans; Phosphodiesterase Inhibitors; Propofol; Rats | 2006 |
Edaravone protects the vestibular periphery from free radical-induced toxicity in response to perilymphatic application of (+/-)-alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid.
Topics: Aldehydes; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antipyrine; Edaravone; Excitatory Amino Acid Agonists; Free Radical Scavengers; Free Radicals; Guinea Pigs; Immunohistochemistry; Infusion Pumps; Male; Nystagmus, Pathologic; Reflex, Vestibulo-Ocular; Vestibular Diseases; Vestibular Function Tests; Vestibule, Labyrinth | 2007 |
Cysteinyl leukotriene receptor 1 is involved in N-methyl-D-aspartate-mediated neuronal injury in mice.
Topics: Animals; Antioxidants; Antipyrine; Brain; Brain Injuries; Chromones; Edaravone; Ketamine; Male; Membrane Proteins; Mice; N-Methylaspartate; Neurons; Receptors, Leukotriene; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Up-Regulation | 2006 |
Alkoxyl radical-scavenging activity of edaravone in patients with traumatic brain injury.
Topics: Adult; Alcohols; Antipyrine; Brain Injuries; Edaravone; Electron Spin Resonance Spectroscopy; Female; Free Radical Scavengers; Humans; In Vitro Techniques; Male; Middle Aged; Oxidative Stress; Spin Trapping | 2006 |
Does edaravone (MCI- 186) act as an antioxidant and a neuroprotector in experimental traumatic brain injury?
Topics: alpha-Tocopherol; Animals; Antioxidants; Antipyrine; Blood; Brain Injuries; Edaravone; Free Radical Scavengers; Humans; Lipid Peroxidation; Neurons; Neuroprotective Agents; Nitric Oxide; Rats; Reactive Oxygen Species; Time Factors | 2007 |
MCI-186 administered to the maternal circulation inhibits fetal brain injury resulting from total umbilical cord occlusion in the chronically instrumented fetal lamb.
Topics: Animals; Antipyrine; Brain Injuries; Edaravone; Female; Fetal Hypoxia; Free Radical Scavengers; Maternal-Fetal Exchange; Pregnancy; Regional Blood Flow; Sheep; Umbilical Cord | 2006 |
Wide therapeutic time window for fasudil neuroprotection against ischemia-induced delayed neuronal death in gerbils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antipyrine; Cell Death; Dose-Response Relationship, Drug; Edaravone; Free Radical Scavengers; Gerbillinae; Ischemia; Male; Neurons; Neuroprotective Agents; Time Factors | 2007 |
Protective effect of radical scavenger edaravone against puromycin nephrosis.
Topics: Animals; Antipyrine; Disease Models, Animal; Edaravone; Follow-Up Studies; Free Radical Scavengers; Kidney Glomerulus; Male; Nephrosis; Puromycin; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Treatment Outcome | 2006 |
Effects of edaravone on singlet oxygen released from activated human neutrophils.
Topics: Adult; Antipyrine; Dose-Response Relationship, Drug; Edaravone; Free Radical Scavengers; Histidine; Humans; Luminescent Measurements; Neutrophil Activation; Neutrophils; Singlet Oxygen | 2007 |
Edaravone inhibits lipid peroxidation in neonatal hypoxic-ischemic rats: an in vivo microdialysis study.
Topics: Animals; Animals, Newborn; Antipyrine; Dose-Response Relationship, Drug; Edaravone; Electron Spin Resonance Spectroscopy; Extracellular Fluid; Free Radical Scavengers; Free Radicals; Hippocampus; Hypoxia-Ischemia, Brain; Lipid Peroxidation; Microdialysis; Nerve Degeneration; Oxidative Stress; Pyridines; Rats; Rats, Wistar; Treatment Outcome | 2007 |
Effect of prophylactically administered edaravone during antegrade cerebral perfusion in a canine model of old cerebral infarction.
Topics: Analysis of Variance; Animals; Antipyrine; Blood Chemical Analysis; Cardiopulmonary Bypass; Cerebral Infarction; Cerebrovascular Circulation; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Edaravone; Evoked Potentials, Somatosensory; Female; Infusions, Intravenous; Preoperative Care; Probability; Random Allocation; Reference Values; Reperfusion; Reperfusion Injury; Sensitivity and Specificity | 2007 |
Effects of edaravone in heart of aged rats after cerebral ischemia-reperfusion injury.
Topics: Aging; Animals; Antipyrine; Apoptosis; Blotting, Western; Brain Ischemia; Cell Survival; Disease Models, Animal; Edaravone; Enzyme-Linked Immunosorbent Assay; Free Radical Scavengers; Glutathione Peroxidase; Heart Injuries; In Situ Nick-End Labeling; Injections, Intravenous; Male; Myocardium; p38 Mitogen-Activated Protein Kinases; Protein Carbonylation; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2007 |
Hydroxyl radical mediates the augmented angiotensin II responses in thoracic aorta of spontaneously hypertensive rats.
Topics: Angiotensin II; Animals; Antipyrine; Aorta, Thoracic; Dose-Response Relationship, Drug; Edaravone; Free Radical Scavengers; Hydrogen Peroxide; Hydroxyl Radical; Muscle, Smooth, Vascular; Peroxides; Rats; Rats, Inbred SHR; Rats, Inbred WKY; tert-Butylhydroperoxide; Vasoconstriction | 2007 |
Urgent endarterectomy using pretreatment with free radical scavenger, edaravone, and early clamping of the parent arteries for cervical carotid artery stenosis with crescendo transient ischemic attacks caused by mobile thrombus and hemodynamic cerebral is
Topics: Aged; Antipyrine; Carotid Stenosis; Edaravone; Endarterectomy, Carotid; Free Radical Scavengers; Humans; Ischemic Attack, Transient; Male; Thrombosis | 2007 |
Microcirculatory changes in experimental mesenteric longitudinal ulcers of the small intestine in rats.
Topics: Allopurinol; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Cytokines; Disease Models, Animal; Disease Progression; Edaravone; Enzyme-Linked Immunosorbent Assay; Free Radical Scavengers; Ileal Diseases; Ileum; Indomethacin; Laser-Doppler Flowmetry; Male; Mesentery; Microcirculation; Peroxidase; Rats; Rats, Wistar; Regional Blood Flow; Ulcer | 2007 |
Edaravone, a radical scavenger, inhibits mitochondrial permeability transition pore in rat brain.
Topics: Animals; Antipyrine; Brain; Calcium; Dose-Response Relationship, Drug; Edaravone; Free Radical Scavengers; Hydrogen Peroxide; Male; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Mitochondrial Swelling; Rats; Rats, Wistar; Reactive Oxygen Species | 2007 |
Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a radical scavenger, prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the substantia nigra but not the striatum.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Antipyrine; Brain; Corpus Striatum; Dopamine; Edaravone; Free Radical Scavengers; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Microglia; Motor Activity; MPTP Poisoning; Neuroprotective Agents; Substantia Nigra; Tyrosine 3-Monooxygenase | 2007 |
Melatonin influences the proliferative and differentiative activity of neural stem cells.
Topics: Animals; Antioxidants; Antipyrine; Astrocytes; Cell Differentiation; Cell Proliferation; Cells, Cultured; Edaravone; Embryonic Stem Cells; Epidermal Growth Factor; Melatonin; Mice; Neurons | 2007 |
Improvement of postischemic dopaminergic dysfunction by edaravone, a free radical scavenger.
Topics: Animals; Antipyrine; Corpus Striatum; Dialysis Solutions; Dopamine; Dose-Response Relationship, Drug; Edaravone; Free Radical Scavengers; Ischemic Attack, Transient; Male; Microdialysis; Neurons; Potassium; Rats; Rats, Wistar | 2007 |
A case report of acute renal failure and fulminant hepatitis associated with edaravone administration in a cerebral infarction patient.
Topics: Acute Kidney Injury; Antipyrine; Cerebral Infarction; Disseminated Intravascular Coagulation; Edaravone; Free Radical Scavengers; Hepatitis; Humans; Male; Middle Aged; Plasma Exchange; Renal Dialysis | 2007 |
Human organic anion transporters 1 (hOAT1/SLC22A6) and 3 (hOAT3/SLC22A8) transport edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one) and its sulfate conjugate.
Topics: Antipyrine; Biological Transport; Cell Line; Cell Proliferation; Edaravone; Free Radical Scavengers; Glucuronides; Humans; Kidney; Kidney Tubules, Proximal; Kinetics; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Sulfuric Acid Esters; Transfection | 2007 |
Preventive and curative effect of edaravone on nerve functions and oxidative stress in experimental diabetic neuropathy.
Topics: Animals; Antipyrine; Catalase; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Edaravone; Free Radical Scavengers; Lipid Peroxidation; Male; Neural Conduction; Oxidative Stress; Pain; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sciatic Nerve; Superoxide Dismutase; Tibial Nerve; Vascular Resistance | 2007 |
Effect of edaravone, a free radical scavenger, on ischemic cerebral edema assessed by magnetic resonance imaging.
Topics: Aged; Aged, 80 and over; Antipyrine; Brain Edema; Brain Ischemia; Edaravone; Female; Free Radical Scavengers; Humans; Magnetic Resonance Imaging; Male | 2007 |
Efficacy of MCI-186, a free-radical scavenger and antioxidant, for resuscitation of nonbeating donor hearts.
Topics: Analysis of Variance; Animals; Antioxidants; Antipyrine; Cardiopulmonary Resuscitation; Edaravone; Free Radical Scavengers; Heart Function Tests; Heart Transplantation; Lipid Peroxidation; Statistics, Nonparametric; Swine | 2007 |
Differential inhibition by oxygen radicals of vasoactive amines-induced contractions in the porcine coronary artery.
Topics: Acetylcholine; Animals; Antipyrine; Calcium; Coronary Vessels; Edaravone; Free Radicals; Histamine; Hydrogen Peroxide; Serotonin; Swine; Vasoconstriction; Xanthine; Xanthine Oxidase | 2007 |
Nitric oxide-induced apoptosis in cultured rat astrocytes: protection by edaravone, a radical scavenger.
Topics: Animals; Antipyrine; Apoptosis; Apoptosis Inducing Factor; Astrocytes; Cell Nucleus; Cell Survival; Cells, Cultured; Edaravone; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Free Radical Scavengers; JNK Mitogen-Activated Protein Kinases; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats; Rats, Wistar; Reactive Oxygen Species | 2007 |
MCI-186 prevents brain tissue from neuronal damage in cerebral infarction through the activation of intracellular signaling.
Topics: Animals; Animals, Newborn; Antipyrine; Brain Edema; Butadienes; Cell Death; Cells, Cultured; Cerebral Infarction; Chromones; Dose-Response Relationship, Drug; Drug Interactions; Edaravone; Enzyme Inhibitors; Free Radical Scavengers; Male; Morpholines; Nerve Tissue Proteins; Neurons; Nitriles; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Rats; Rats, Wistar; Signal Transduction; Time Factors | 2007 |
Edaravone inhibits collagen-induced arthritis possibly through suppression of nuclear factor-kappa B.
Topics: Animals; Antipyrine; Arthritis, Experimental; Caspase 3; Caspase 7; Cells, Cultured; Edaravone; Female; Humans; Interleukin-6; Male; Matrix Metalloproteinase 3; Mice; Synovial Membrane; Transcription Factor RelA | 2008 |
Evaluation of the role of breast cancer resistance protein (BCRP/ABCG2) and multidrug resistance-associated protein 4 (MRP4/ABCC4) in the urinary excretion of sulfate and glucuronide metabolites of edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one).
Topics: Adenosine Triphosphate; Animals; Antipyrine; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport, Active; Cell Line; Cell Membrane; Edaravone; Female; Free Radical Scavengers; Glucuronides; Glutathione; Humans; Kidney; Kidney Tubules; Metabolic Clearance Rate; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Models, Biological; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Sulfuric Acid Esters; Transfection | 2007 |
Edaravone mimics sphingosine-1-phosphate-induced endothelial barrier enhancement in human microvascular endothelial cells.
Topics: Actins; Adherens Junctions; Antipyrine; Capillary Permeability; Cardiovascular Agents; Cells, Cultured; Edaravone; Electric Impedance; Endothelial Cells; Focal Adhesion Kinase 1; Focal Adhesions; Free Radical Scavengers; Humans; Lysophospholipids; Microcirculation; Paxillin; Phosphorylation; rac GTP-Binding Proteins; Receptors, Lysosphingolipid; RNA Interference; RNA, Small Interfering; Signal Transduction; Sphingosine; Time Factors | 2007 |
Effects of MCI-186 upon neutrophil-derived active oxygens.
Topics: Antipyrine; Edaravone; Free Radical Scavengers; Humans; Hypochlorous Acid; Luminescent Measurements; Luminol; Neutrophils; Reactive Oxygen Species; Spectrophotometry; Superoxides; Time Factors | 2007 |
The free-radical scavenger edaravone restores the differentiation of human neural precursor cells after radiation-induced oxidative stress.
Topics: Animals; Antipyrine; Brain Neoplasms; Cell Differentiation; Cells, Cultured; Edaravone; Free Radical Scavengers; Glioma; Humans; Mice; Mice, Inbred C57BL; Neurons; Oxidative Stress; Radiation Injuries; Stem Cells | 2007 |
Edaravone preserves coronary microvascular endothelial function after ischemia/reperfusion on the beating canine heart in vivo.
Topics: Animals; Antipyrine; Blood Pressure; Blotting, Western; Coronary Circulation; Coronary Vessels; Dogs; Edaravone; Endothelium, Vascular; Female; Free Radical Scavengers; Heart Rate; Male; Microscopy; Myocardial Reperfusion Injury; Nitric Oxide; Reactive Oxygen Species; Vasodilation | 2007 |
Pulse radiolysis study on free radical scavenger edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one).
Topics: Absorption; Antipyrine; Edaravone; Free Radical Scavengers; Free Radicals; Hydrogen-Ion Concentration; Kinetics; Oxidation-Reduction; Pulse Radiolysis | 2007 |
Protective effect of edaravone against endolymphatic hydrops.
Topics: Animals; Antipyrine; Disease Models, Animal; Drug Administration Schedule; Edaravone; Endolymphatic Hydrops; Female; Follow-Up Studies; Free Radical Scavengers; Guinea Pigs; Injections, Intraperitoneal; Microscopy, Fluorescence; Reactive Oxygen Species; Treatment Outcome | 2007 |
Edaravone inhibits the expression of vascular endothelial growth factor in human astrocytes exposed to hypoxia.
Topics: Antipyrine; Astrocytes; Blood-Brain Barrier; Brain Edema; Cell Nucleus; Cells, Cultured; Cerebral Arteries; Dose-Response Relationship, Drug; Down-Regulation; Edaravone; Endothelium, Vascular; Free Radical Scavengers; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia, Brain; Promoter Regions, Genetic; Protein Binding; RNA, Messenger; Vascular Endothelial Growth Factor A | 2007 |
Edaravone, a potent free radical scavenger, prevents anthracycline-induced myocardial cell death.
Topics: Animals; Anthracyclines; Antipyrine; Apoptosis; Caspase 3; Cell Survival; Cells, Cultured; Daunorubicin; Edaravone; Free Radical Scavengers; L-Lactate Dehydrogenase; Myocytes, Cardiac; Necrosis; Rats; Rats, Sprague-Dawley | 2007 |
Free radical scavenger edaravone suppresses x-ray-induced apoptosis through p53 inhibition in MOLT-4 cells.
Topics: Antipyrine; Apoptosis; Cell Line, Tumor; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Edaravone; Free Radical Scavengers; Humans; Leukemia, T-Cell; Radiation Tolerance; Radiation-Protective Agents; Tumor Suppressor Protein p53; X-Rays | 2007 |
Edaravone neuroprotection effected by suppressing the gene expression of the Fas signal pathway following transient focal ischemia in rats.
Topics: Animals; Antipyrine; Death Domain Receptor Signaling Adaptor Proteins; Disease Models, Animal; DNA Fragmentation; Edaravone; Gene Expression Regulation; In Situ Nick-End Labeling; Ischemic Attack, Transient; Male; Neurologic Examination; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Signal Transduction; Statistics, Nonparametric | 2007 |
A novel inhibitor of advanced glycation and endoplasmic reticulum stress reduces infarct volume in rat focal cerebral ischemia.
Topics: Animals; Antioxidants; Antipyrine; Benzenesulfonates; Blood Pressure; Brain Ischemia; Cell Death; Dose-Response Relationship, Drug; Edaravone; Endoplasmic Reticulum; Furans; Glycation End Products, Advanced; Immunohistochemistry; Indicators and Reagents; Infarction, Middle Cerebral Artery; Intracranial Thrombosis; Male; Mice; Mice, Knockout; Neuroprotective Agents; Oxidation-Reduction; Oxidative Stress; Protein Denaturation; Pyridines; Rats; Rats, Sprague-Dawley | 2007 |
Protective effects of edaravone against ischemia-induced facial palsy.
Topics: Animals; Antipyrine; Axons; Blinking; Edaravone; Facial Nerve; Facial Paralysis; Free Radical Scavengers; Geniculate Ganglion; Guinea Pigs; Injections, Intraperitoneal; Ischemia; Microscopy, Electron; Microscopy, Fluorescence; Myelin Sheath; Reactive Oxygen Species | 2008 |
The radical scavenger edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) reacts with a pterin derivative and produces a cytotoxic substance that induces intracellular reactive oxygen species generation and cell death.
Topics: Antipyrine; Cell Death; Cell Survival; Cells, Cultured; Cytotoxins; Edaravone; Free Radical Scavengers; Humans; Intracellular Fluid; Pterins; Reactive Oxygen Species | 2008 |
Amelioration of hepatic ischemia/reperfusion injury in the remnant liver after partial hepatectomy in rats.
Topics: Animals; Antipyrine; Edaravone; Free Radical Scavengers; Gene Expression Regulation; Hepatectomy; Interleukin-6; Liver; Liver Diseases; Male; Peroxidase; Rats; Rats, Wistar; Reperfusion Injury; RNA, Messenger; Survival Rate | 2007 |
Spontaneous resolution of isolated dissecting aneurysm on the posterior inferior cerebellar artery.
Topics: Administration, Oral; Adult; Antipyrine; Aortic Dissection; Cerebellar Diseases; Dilatation, Pathologic; Edaravone; Humans; Infusions, Intravenous; Intracranial Aneurysm; Magnetic Resonance Angiography; Male; Platelet Aggregation Inhibitors; Pyridines; Remission, Spontaneous; Tomography, X-Ray Computed | 2008 |
Edaravone prevents iNOS expression by inhibiting its promoter transactivation and mRNA stability in cytokine-stimulated hepatocytes.
Topics: Animals; Antipyrine; Cells, Cultured; Edaravone; Free Radical Scavengers; Hepatocytes; Interleukin-1beta; Male; Nitric Oxide Synthase Type II; Promoter Regions, Genetic; Rats; Rats, Wistar; RNA, Messenger; Transcriptional Activation | 2008 |
Clinical analysis of 207 patients who developed renal disorders during or after treatment with edaravone reported during post-marketing surveillance.
Topics: Aged; Aged, 80 and over; Antipyrine; Blood Urea Nitrogen; Creatinine; Edaravone; Female; Free Radical Scavengers; Hemoperfusion; Humans; Hypotension; Japan; Kidney Diseases; Male; Product Surveillance, Postmarketing; Recovery of Function; Retrospective Studies; Risk Assessment; Risk Factors; Sepsis; Severity of Illness Index; Stroke; Time Factors | 2007 |
Edaravone attenuates brain edema and neurologic deficits in a rat model of acute intracerebral hemorrhage.
Topics: Acute Disease; Animals; Antipyrine; Basal Ganglia; Brain Edema; Cerebral Cortex; Cerebral Hemorrhage; Disease Models, Animal; Edaravone; Free Radical Scavengers; Male; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Sprague-Dawley; Water | 2008 |
Antioxidants block proteasome inhibitor function in endometrial carcinoma cells.
Topics: Antioxidants; Antipyrine; Apoptosis; Ascorbic Acid; Blotting, Western; Boronic Acids; Bortezomib; Butylated Hydroxyanisole; Caspase 3; Caspase 9; Caspase Inhibitors; Cell Line, Tumor; Cell Survival; Coumarins; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Edaravone; Endometrial Neoplasms; Ergothioneine; Female; Humans; Leupeptins; Oligopeptides; Proteasome Inhibitors; Pyrazines; Ubiquitin; Vitamin E; Vitamins | 2008 |
Edaravone prevents Fas-induced fulminant hepatic failure in mice by regulating mitochondrial Bcl-xL and Bax.
Topics: Animals; Antipyrine; bcl-2-Associated X Protein; bcl-X Protein; Edaravone; fas Receptor; Female; Free Radical Scavengers; Liver Failure, Acute; Mice; Mice, Inbred BALB C; Mitochondria, Liver; Mitochondrial Proteins; Survival Analysis | 2008 |
The radical scavenger edaravone counteracts diabetes in multiple low-dose streptozotocin-treated mice.
Topics: Animals; Antipyrine; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Edaravone; Free Radical Scavengers; Hyperglycemia; Hypoglycemic Agents; Insulin; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Pancreas; Thiobarbituric Acid Reactive Substances | 2008 |
Edaravone prevents kainic acid-induced neuronal death.
Topics: Aldehydes; Animals; Antipyrine; Brain; Cell Death; Disease Models, Animal; Down-Regulation; Edaravone; Epilepsy; Free Radical Scavengers; Glutathione; Kainic Acid; Lipid Peroxidation; Male; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Rats; Rats, Sprague-Dawley; Status Epilepticus; Treatment Outcome | 2008 |
Dihydroartemisinin potentiates the cytotoxic effect of temozolomide in rat C6 glioma cells.
Topics: Animals; Antineoplastic Agents; Antipyrine; Apoptosis; Artemisinins; Cell Survival; Cisplatin; Dacarbazine; Drug Synergism; Edaravone; Free Radical Scavengers; Glioma; Rats; Reactive Oxygen Species; Temozolomide; Tumor Cells, Cultured | 2008 |
Protective effect of serofendic acid on ischemic injury induced by occlusion of the middle cerebral artery in rats.
Topics: Animals; Antipyrine; Body Weight; Brain Ischemia; Cerebrovascular Circulation; Diterpenes; Dose-Response Relationship, Drug; Edaravone; Infarction, Middle Cerebral Artery; Male; Middle Cerebral Artery; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2008 |
Inhibition of neointimal hyperplasia development by MCI-186 is correlated with downregulation of nuclear factor-kappaB pathway.
Topics: Angioplasty, Balloon; Animals; Antioxidants; Antipyrine; Carotid Artery Diseases; Carotid Artery Injuries; Carotid Artery, Common; Cholesterol; Disease Models, Animal; Down-Regulation; E-Selectin; Edaravone; Free Radical Scavengers; Hyperplasia; I-kappa B Proteins; Interleukin-1beta; Male; NF-kappa B; NF-KappaB Inhibitor alpha; Rabbits; Signal Transduction; Superoxides; Tunica Intima | 2008 |
The novel antioxidant edaravone: from bench to bedside.
Topics: Animals; Anti-Inflammatory Agents; Antipyrine; Drug Evaluation, Preclinical; Edaravone; Free Radical Scavengers; Humans; Japan; Molecular Structure; Oxidative Stress; Reactive Oxygen Species; Reperfusion Injury; Stroke; Structure-Activity Relationship; Treatment Outcome | 2008 |
Edaravone inhibits the induction of iNOS gene expression at transcriptional and posttranscriptional steps in murine macrophages.
Topics: Animals; Antipyrine; Blotting, Northern; Blotting, Western; Cell Line; Edaravone; Free Radical Scavengers; Gene Expression; Macrophages; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Promoter Regions, Genetic; RNA Stability; RNA, Messenger; Transcription, Genetic | 2008 |
In vitro metabolism study of edaravone in Wistar and hairless rat skin.
Topics: Animals; Antipyrine; Chromatography, High Pressure Liquid; Edaravone; Free Radical Scavengers; In Vitro Techniques; Male; Rats; Rats, Hairless; Rats, Wistar; Skin; Subcellular Fractions | 2008 |
[Case of transient cortical blindness due to thrombosis of the transverse sinus].
Topics: Antipyrine; Blindness, Cortical; Edaravone; Heparin; Humans; Lateral Sinus Thrombosis; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Male; Middle Aged; Tomography, X-Ray Computed; Treatment Outcome | 2008 |
[Protective effects of edaravone on renal ischemia-reperfusion injury in rats].
Topics: Animals; Antipyrine; Edaravone; Kidney; Male; Malondialdehyde; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase | 2008 |
Edaravone improves the survival of rats subjected to hemorrhagic shock without resuscitation.
Topics: Animals; Antipyrine; Disease Models, Animal; Edaravone; Free Radical Scavengers; Male; Rats; Rats, Sprague-Dawley; Resuscitation; Shock, Hemorrhagic; Survival Analysis; Time Factors | 2008 |
Edaravone (MCI-186), a free radical scavenger, attenuates retinal ischemia/reperfusion injury in rats.
Topics: Animals; Antipyrine; Apoptosis; Edaravone; Electroretinography; Free Radical Scavengers; In Situ Nick-End Labeling; Male; Malondialdehyde; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Retinal Diseases; Superoxide Dismutase | 2008 |
Combination effects of normobaric hyperoxia and edaravone on focal cerebral ischemia-induced neuronal damage in mice.
Topics: Animals; Antipyrine; Blood Pressure; Cell Death; Cerebral Infarction; Disease Models, Animal; Edaravone; Free Radical Scavengers; Hyperbaric Oxygenation; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Male; Mice; Neurologic Examination; Neurons; Tetrazolium Salts | 2008 |
Edaravone, a free radical scavenger, ameliorates experimental autoimmune encephalomyelitis.
Topics: Animals; Antipyrine; Calcium-Binding Proteins; CD3 Complex; Cell Line, Transformed; Disease Models, Animal; Down-Regulation; Edaravone; Encephalomyelitis, Autoimmune, Experimental; Female; Free Radical Scavengers; Mice; Microfilament Proteins; Microglia; Nitric Oxide Synthase Type II; Spinal Cord; Statistics, Nonparametric | 2008 |
Protective effect of edaravone against tobramycin-induced ototoxicity.
Topics: Animals; Anti-Bacterial Agents; Antipyrine; Drug Administration Schedule; Edaravone; Evoked Potentials, Auditory, Brain Stem; Free Radical Scavengers; Hearing Loss, Central; Hearing Loss, Sensorineural; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Tobramycin | 2009 |
Effects of edaravone, a free-radical scavenger, on bleomycin-induced lung injury in mice.
Topics: Animals; Antipyrine; Bleomycin; Bronchoalveolar Lavage Fluid; Dinoprostone; Edaravone; Female; Free Radical Scavengers; Lipids; Lung; Lung Injury; Mice; Mice, Inbred ICR; Oxidative Stress; Pulmonary Fibrosis; Reactive Oxygen Species | 2008 |
[Multi-center survey of edaravone treatment in children].
Topics: Antipyrine; Child; Child, Preschool; Data Collection; Drug Utilization; Edaravone; Female; Free Radical Scavengers; Humans; Infant; Japan; Male | 2008 |
Edaravone protects against MPP+ -induced cytotoxicity in rat primary cultured astrocytes via inhibition of mitochondrial apoptotic pathway.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Animals, Newborn; Antipyrine; Apoptosis; Astrocytes; Brain; Cells, Cultured; Cytoprotection; Edaravone; Energy Metabolism; Free Radical Scavengers; Mitochondria; Nerve Degeneration; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2008 |
Comparative pharmacological study of free radical scavenger, nitric oxide synthase inhibitor, nitric oxide synthase activator and cyclooxygenase inhibitor against MPTP neurotoxicity in mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antipyrine; Cyclooxygenase Inhibitors; Dopamine; Edaravone; Enzyme Activators; Enzyme Inhibitors; Etodolac; Fatty Acids, Monounsaturated; Fluvastatin; Free Radical Scavengers; Homovanillic Acid; Indazoles; Indoles; Indomethacin; Male; Mice; Mice, Inbred C57BL; Minocycline; MPTP Poisoning; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Quinolines | 2008 |
Administration of free radical scavenger edaravone associated with higher frequency of hemorrhagic transformation in patients with cardiogenic embolism.
Topics: Aged; Aged, 80 and over; Antipyrine; Cerebral Hemorrhage; Dose-Response Relationship, Drug; Edaravone; Female; Free Radical Scavengers; Heart Diseases; Humans; Infusions, Intravenous; Intracranial Embolism; Male; Middle Aged; Prognosis; Retrospective Studies; Risk Factors; Thrombosis; Treatment Outcome | 2008 |
Biphasic effects of free radical scavengers against bleomycin-induced pulmonary fibrosis.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antipyrine; Apoptosis; Bleomycin; Bronchi; Bronchoalveolar Lavage Fluid; Deoxyguanosine; Dose-Response Relationship, Drug; Edaravone; Epithelial Cells; Free Radical Scavengers; Hydroxyproline; Immunohistochemistry; Injections, Intraperitoneal; Intubation, Intratracheal; Lipid Peroxides; Lung; Male; Mice; Mice, Inbred C57BL; Pulmonary Fibrosis; Time Factors | 2008 |
Neuroprotective effects of edaravone-administration on 6-OHDA-treated dopaminergic neurons.
Topics: Animals; Antipyrine; Cell Survival; Cells, Cultured; Dopamine; Edaravone; Female; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Substantia Nigra | 2008 |
Neuroprotective effects of edaravone, a free radical scavenger, on the rat hippocampus after pilocarpine-induced status epilepticus.
Topics: Animals; Antipyrine; Cell Count; Disease Models, Animal; Dose-Response Relationship, Drug; Edaravone; Hippocampus; Male; Neuroprotective Agents; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pilocarpine; Rats; Rats, Wistar; Reaction Time; Status Epilepticus; Time Factors | 2009 |
Preventive effects of edaravone, a free radical scavenger, on lipopolysaccharide-induced lung injury in mice.
Topics: Acute Lung Injury; Animals; Antipyrine; Cell Line; Chemokine CXCL2; Disease Models, Animal; Edaravone; Female; Free Radical Scavengers; Interleukin-6; Lipid Peroxidation; Lipopolysaccharides; Macrophages, Alveolar; Mice; Mice, Inbred BALB C; Oxidative Stress; Tumor Necrosis Factor-alpha | 2008 |
Treatment with edaravone, initiated at symptom onset, slows motor decline and decreases SOD1 deposition in ALS mice.
Topics: Amyotrophic Lateral Sclerosis; Animals; Antipyrine; Edaravone; Female; Humans; Male; Mice; Mice, Transgenic; Motor Skills; Motor Skills Disorders; Superoxide Dismutase; Superoxide Dismutase-1; Time Factors | 2008 |
Reactive oxygen species generation through NADH oxidation by pterin derivatives.
Topics: Antipyrine; Edaravone; NAD; Oxidation-Reduction; Pteridines; Pterins; Reactive Oxygen Species | 2008 |
A free radical scavenger, edaravone, prevents ischemia-reperfusion injury in liver grafts from non-heart-beating donors.
Topics: Animals; Antipyrine; Aspartate Aminotransferases; Bile; Cadaver; Edaravone; Free Radical Scavengers; L-Lactate Dehydrogenase; Liver Transplantation; Male; Portal System; Rats; Rats, Wistar; Reperfusion Injury; Tissue Donors | 2008 |
Bilateral middle cerebral artery infarctions following mild varicella infection: a case report.
Topics: Acyclovir; Antipyrine; Antiviral Agents; Chickenpox; Child, Preschool; DNA, Viral; Edaravone; Herpesvirus 3, Human; Humans; Infarction, Middle Cerebral Artery; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Male; Polymerase Chain Reaction; Treatment Outcome | 2009 |
Expression of syndecan-2 in the amoeboid microglial cells and its involvement in inflammation in the hypoxic developing brain.
Topics: Age Factors; Animals; Animals, Newborn; Antipyrine; Cell Movement; Cells, Cultured; Corpus Callosum; Cytokines; Edaravone; Flow Cytometry; Free Radical Scavengers; Gene Expression Regulation, Developmental; Hypoxia; Microglia; Rats; Reactive Oxygen Species; RNA, Messenger; Syndecan-2 | 2009 |
[Outcome assessment in treatment of edaravone in childhood ischemic stroke].
Topics: Adolescent; Antipyrine; Cerebral Infarction; Child; Child, Preschool; Edaravone; Female; Free Radical Scavengers; Humans; Infant; Male; Retrospective Studies; Treatment Outcome | 2008 |
The lipophilic multifunctional antioxidant edaravone (radicut) improves behavior following embolic strokes in rabbits: a combination therapy study with tissue plasminogen activator.
Topics: Animals; Antipyrine; Behavior, Animal; Carotid Artery Thrombosis; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Edaravone; Fibrinolytic Agents; Free Radical Scavengers; Logistic Models; Rabbits; Stroke; Time Factors; Tissue Plasminogen Activator | 2009 |
Oxygen-glucose deprivation activates 5-lipoxygenase mediated by oxidative stress through the p38 mitogen-activated protein kinase pathway in PC12 cells.
Topics: 5-Lipoxygenase-Activating Proteins; Animals; Antioxidants; Antipyrine; Arachidonate 5-Lipoxygenase; Caffeic Acids; Carrier Proteins; Cell Hypoxia; Edaravone; Enzyme Activation; Enzyme Inhibitors; Glucose; Hydrogen Peroxide; Hydroxyurea; Imidazoles; Indoles; Leukotrienes; Lipoxygenase Inhibitors; MAP Kinase Signaling System; Membrane Proteins; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Phosphorylation; Pyridines; Rats; Reactive Oxygen Species; Transfection | 2009 |
Pretreatment with edaravone reduces lung mitochondrial damage in an infant rabbit ischemia-reperfusion model.
Topics: Acute Lung Injury; Animals; Animals, Suckling; Antipyrine; Constriction; Disease Models, Animal; Edaravone; Female; Hemodynamics; Lung; Male; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Swelling; Premedication; Rabbits; Random Allocation; Reactive Oxygen Species; Reperfusion Injury; Ventilator-Induced Lung Injury | 2008 |
Edaravone attenuates ischemia-reperfusion injury by inhibiting oxidative stress in a canine lung transplantation model.
Topics: Animals; Antipyrine; Disease Models, Animal; Dogs; Edaravone; Lipid Peroxidation; Lung; Lung Transplantation; Nitric Oxide; Oxidative Stress; Peroxidase; Reperfusion Injury | 2008 |
[A comparison of protective effect of propofol and edaravone pretreatment against cerebral ischemia-reperfusion injury].
Topics: Animals; Antipyrine; Apoptosis; Brain Ischemia; Cell Survival; Cells, Cultured; Cerebral Cortex; Edaravone; Neurons; Propofol; Rats; Reperfusion Injury | 2008 |
Edaravone, a free radical scavenger, is effective on neuropathic pain in rats.
Topics: Analgesics; Animals; Antipyrine; Blotting, Western; Cells, Cultured; Chronic Disease; Edaravone; Free Radical Scavengers; Ganglia, Spinal; Janus Kinases; Neuralgia; Pain Measurement; Pain Threshold; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Spinal Nerves | 2009 |
Correlation of free radical level and apoptosis after intracerebral hemorrhage in rats.
Topics: Analysis of Variance; Animals; Antipyrine; Apoptosis; Cerebral Hemorrhage; Disease Models, Animal; Dose-Response Relationship, Drug; Edaravone; Free Radical Scavengers; Hydroxyl Radical; In Situ Nick-End Labeling; Linear Models; Male; Malondialdehyde; Random Allocation; Rats; Rats, Sprague-Dawley; Time Factors | 2008 |
Determinants for the prognosis of acute renal disorders that developed during or after treatment with edaravone.
Topics: Acute Kidney Injury; Antipyrine; Brain Ischemia; Edaravone; Free Radical Scavengers; Humans; Logistic Models; Prognosis; Recovery of Function; Risk Factors; Stroke; Survival Rate | 2009 |
[Cardioprotective effect of edaravone pharmacological postconditioning on acute myocardial ischemia/reperfusion injury: experiment with rats].
Topics: Animals; Antipyrine; Disease Models, Animal; Edaravone; Free Radical Scavengers; Male; Myocardial Reperfusion Injury; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species | 2008 |
Edaravone, a free radical scavenger, inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator.
Topics: Animals; Antipyrine; Blood Pressure; Blotting, Western; Brain Ischemia; Cells, Cultured; Cerebral Hemorrhage; Dose-Response Relationship, Drug; Edaravone; Endothelial Cells; Free Radical Scavengers; Immunohistochemistry; Infarction, Middle Cerebral Artery; Male; Matrix Metalloproteinase Inhibitors; Middle Cerebral Artery; NF-kappa B; Rats; Rats, Wistar; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tissue Plasminogen Activator | 2009 |
Edaravone (MCI-186) scavenges reactive oxygen species and ameliorates tissue damage in the murine spinal cord injury model.
Topics: Animals; Antipyrine; Drug Evaluation, Preclinical; Edaravone; Female; Free Radical Scavengers; Hindlimb; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Nerve Tissue Proteins; Neuroprotective Agents; Premedication; Reactive Oxygen Species; Recovery of Function; Spinal Cord; Spinal Cord Injuries; Superoxides | 2008 |
Edaravone derivatives containing NO-donor functions.
Topics: Antioxidants; Antipyrine; Edaravone; Nitric Oxide Donors; Vasodilator Agents | 2009 |
Expression of angiotensin II and its receptors in the normal and hypoxic amoeboid microglial cells and murine BV-2 cells.
Topics: Angiotensin II; Animals; Animals, Newborn; Antibodies; Antipyrine; Cell Hypoxia; Cells, Cultured; Corpus Callosum; Cytokines; Dose-Response Relationship, Drug; Edaravone; Free Radical Scavengers; Gene Expression Regulation; Hypoxia; Immunoenzyme Techniques; Lipopolysaccharides; Mice; Microglia; Rats; Rats, Wistar; Receptors, Angiotensin; RNA, Messenger; Time Factors | 2009 |
Dissociation and protection of the neurovascular unit after thrombolysis and reperfusion in ischemic rat brain.
Topics: Animals; Antipyrine; Basement Membrane; Brain Ischemia; Cerebral Hemorrhage; Edaravone; Free Radical Scavengers; Infarction, Middle Cerebral Artery; Rats; Rats, Inbred SHR; Reperfusion; Thrombolytic Therapy; Tissue Plasminogen Activator | 2009 |
A novel administration route for edaravone: I. Effects of metabolic inhibitors on skin permeability of edaravone.
Topics: Administration, Cutaneous; Animals; Antipyrine; Edaravone; Male; Permeability; Proadifen; Rats; Rats, Hairless; Skin Absorption | 2009 |
A novel fluorescent assay for edaravone with aqueous functional CdSe quantum dots.
Topics: Antipyrine; Biological Assay; Cadmium; Edaravone; Fluorescence; Free Radical Scavengers; Quantum Dots; Selenium; Spectrometry, Fluorescence; Water | 2009 |
Edaravone, a free radical scavenger, protects against retinal damage in vitro and in vivo.
Topics: Animals; Antipyrine; Cell Line; Cell Survival; Culture Media; Disease Models, Animal; Dose-Response Relationship, Drug; Edaravone; Free Radical Scavengers; Free Radicals; Green Fluorescent Proteins; Male; Mice; Mice, Transgenic; N-Methylaspartate; Oxidative Stress; Rats; Retinal Diseases; Retinal Ganglion Cells; Thy-1 Antigens | 2009 |
Edaravone prevents bowel infarction after acute superior mesenteric artery thromboembolism using autologous fibrin clots in a rabbit model.
Topics: Animals; Anticoagulants; Antipyrine; Case-Control Studies; Disease Models, Animal; Edaravone; Fibrin; Free Radical Scavengers; Heparin; Intestine, Small; Mesenteric Artery, Superior; Mesenteric Vascular Occlusion; Rabbits; Random Allocation; Reperfusion Injury; Thromboembolism; Urokinase-Type Plasminogen Activator | 2009 |
Survivin is involved in the anti-apoptotic effect of edaravone in PC12 cells.
Topics: Animals; Antipyrine; Apoptosis; Edaravone; Free Radical Scavengers; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Survivin | 2009 |
Edaravone inhibits DNA peroxidation and neuronal cell death in neonatal hypoxic-ischemic encephalopathy model rat.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Animals, Newborn; Antipyrine; Cell Death; Deoxyguanosine; Disease Models, Animal; DNA; Edaravone; Free Radical Scavengers; Hypoxia-Ischemia, Brain; Neurons; Peroxides; Rats; Rats, Sprague-Dawley | 2009 |
Antifibrotic effect of edaravone in rat liver cirrhosis induced by dimethylnitrosamine.
Topics: Animals; Antipyrine; Bilirubin; Dimethylnitrosamine; Edaravone; Free Radical Scavengers; Histocytochemistry; Liver Cirrhosis; Rats; Severity of Illness Index | 2009 |
Mechanistic insight into neurotoxicity of tissue plasminogen activator-induced thrombolysis products in a rat intraluminal middle cerebral artery occlusion model.
Topics: Animals; Antipyrine; Biomarkers; Brain Ischemia; Cerebrovascular Circulation; DNA Damage; Edaravone; Erythrocytes; Free Radical Scavengers; Free Radicals; Immunohistochemistry; Infarction, Middle Cerebral Artery; Lipid Peroxidation; Male; Middle Cerebral Artery; Rats; Rats, Sprague-Dawley; Thrombolytic Therapy; Tissue Plasminogen Activator | 2009 |
Edaravone in ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Antipyrine; Clinical Trials as Topic; Disease Models, Animal; Edaravone; Free Radical Scavengers; Humans; Inclusion Bodies; Mice; Motor Neurons; Neuroglia; Oxidative Stress; Superoxide Dismutase; Superoxide Dismutase-1 | 2009 |
Protective effects of edaravone against cobalt chloride-induced apoptosis in PC12 cells.
Topics: Animals; Antimutagenic Agents; Antipyrine; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Count; Cell Survival; Cobalt; Dose-Response Relationship, Drug; Drug Interactions; Edaravone; Free Radical Scavengers; Membrane Potential, Mitochondrial; PC12 Cells; Proto-Oncogene Proteins c-bcl-2; Rats; Reactive Oxygen Species | 2009 |
The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1 in neuronal cells.
Topics: Active Transport, Cell Nucleus; Animals; Antipyrine; Apoptosis; Butadienes; Cell Hypoxia; Cell Nucleus; Cerebral Infarction; Cerebrum; Cytochromes c; Cytoplasm; Edaravone; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Free Radical Scavengers; Glucose; HMGB1 Protein; Hydrogen Peroxide; Male; Neurons; Neuroprotective Agents; Nitriles; Oxidative Stress; PC12 Cells; Rats; Rats, Wistar; S100 Proteins | 2009 |
Edaravone, a novel free radical scavenger, reduces high-mobility group box 1 and prolongs survival in a neonatal sepsis model.
Topics: Animals; Animals, Newborn; Antioxidants; Antipyrine; Blood Pressure; Body Weight; Cyclic N-Oxides; Edaravone; Free Radical Scavengers; Free Radicals; Heart Rate; HMGB1 Protein; Inflammation; Sepsis; Spin Labels; Swine; Time Factors | 2009 |
Edaravone reduces brain oedema and attenuates cell death after intracerebral haemorrhage in mice.
Topics: Animals; Antipyrine; Brain; Brain Edema; Cell Death; Cerebral Hemorrhage; Collagenases; Disease Models, Animal; Edaravone; Free Radical Scavengers; Male; Mice; Mice, Inbred C57BL; Water | 2009 |
Acute urinary retention and subsequent catheterization cause lipid peroxidation and oxidative DNA damage in the bladder: preventive effect of edaravone, a free-radical scavenger.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acute Disease; Animals; Antipyrine; Deoxyguanosine; DNA Damage; Edaravone; Free Radical Scavengers; HSP70 Heat-Shock Proteins; Lipid Peroxidation; Male; Malondialdehyde; Oxidative Stress; Random Allocation; Rats; Rats, Sprague-Dawley; Urinary Bladder Diseases; Urinary Catheterization; Urinary Retention | 2009 |
Efficacy of the free radical scavenger, edaravone, for motor palsy of acute lacunar infarction.
Topics: Aged; Antipyrine; Brain Infarction; Edaravone; Female; Free Radical Scavengers; Humans; Male; Middle Aged; Paralysis; Regression Analysis; Retrospective Studies; Treatment Outcome | 2009 |
Reactive oxygen species modulate growth of cerebral aneurysms: a study using the free radical scavenger edaravone and p47phox(-/-) mice.
Topics: Animals; Antipyrine; Base Sequence; DNA Primers; Edaravone; Free Radical Scavengers; Immunohistochemistry; Intracranial Aneurysm; Male; Mice; Mice, Knockout; NADPH Oxidases; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxides; Up-Regulation | 2009 |
Accumulation of oxidative stress around the stroke-like lesions of MELAS patients.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adolescent; Adult; Aged; Aged, 80 and over; Antipyrine; Deoxyguanosine; DNA Glycosylases; Edaravone; Female; Free Radical Scavengers; Histocytochemistry; Humans; Male; MELAS Syndrome; Middle Aged; Neurons; Oxidative Stress; Superoxide Dismutase; Young Adult | 2009 |
Edaravone attenuates white matter lesions through endothelial protection in a rat chronic hypoperfusion model.
Topics: Animals; Antipyrine; Apoptosis; Axons; Blood-Brain Barrier; Brain; Brain Ischemia; Cell Proliferation; Cerebrovascular Circulation; Chronic Disease; DNA Damage; Edaravone; Endothelium, Vascular; Free Radical Scavengers; Lipid Peroxidation; Male; Maze Learning; Memory; Motor Activity; Neuroprotective Agents; Nitric Oxide Synthase Type III; Oligodendroglia; Oxidation-Reduction; Rats; Rats, Wistar | 2009 |
Edaravone, a free radical scavenger, mitigates both gray and white matter damages after global cerebral ischemia in rats.
Topics: Amyloid beta-Protein Precursor; Animals; Antipyrine; Axons; Brain; Brain Ischemia; Edaravone; Free Radical Scavengers; Hippocampus; Immunohistochemistry; Male; Microglia; Microtubule-Associated Proteins; Nerve Fibers, Myelinated; Neurons; Random Allocation; Rats; Rats, Sprague-Dawley; Time Factors | 2009 |
Therapeutic effect of edaravone on inner ear barotrauma in the guinea pig.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Antipyrine; Barotrauma; Cochlea; Deoxyguanosine; Ear, Inner; Edaravone; Evoked Potentials, Auditory, Brain Stem; Female; Free Radical Scavengers; Guinea Pigs; Hearing Loss; Immunohistochemistry; Organ of Corti; Pressure; Spiral Ganglion; Stria Vascularis | 2009 |
Retinal artery embolization during carotid angioplasty and carotid artery stenting: case report.
Topics: Aged; Angioplasty, Balloon; Anticoagulants; Antipyrine; Aspirin; Carotid Artery, External; Carotid Stenosis; Cerebral Infarction; Combined Modality Therapy; Drug Therapy, Combination; Edaravone; Embolism; Heparin; Humans; Hyperbaric Oxygenation; Intraoperative Complications; Male; Methacrylates; Ophthalmic Artery; Recurrence; Retinal Artery Occlusion; Stents; Ticlopidine | 2009 |
Effect of edaravone, a novel free radical scavenger, supplemented to cardioplegia on myocardial function after cardioplegic arrest: in vitro study of isolated rat heart.
Topics: Animals; Antipyrine; Edaravone; Free Radical Scavengers; Heart; Heart Arrest, Induced; In Vitro Techniques; Oxidative Stress; Rats; Reperfusion Injury | 2009 |
Development of cardiac dysfunction induced by repetitive transient myocardial ischemia is inhibited by edaravone in conscious rats.
Topics: Animals; Antipyrine; Consciousness; Disease Models, Animal; Edaravone; Free Radical Scavengers; Hypertrophy, Left Ventricular; Male; Myocardial Ischemia; Myocardium; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Time Factors; Ultrasonography; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Remodeling | 2009 |
Electrophysiological study on differentiation of rat bone marrow stromal stem cells into neuron-like cells in vitro by edaravone.
Topics: Animals; Antipyrine; Blotting, Western; Bone Marrow Cells; Cell Differentiation; Edaravone; Male; Neurons; Rats; Rats, Sprague-Dawley; Stromal Cells | 2009 |
Edaravone, a free radical scavenger, retards the development of amygdala kindling in rats.
Topics: Animals; Anticonvulsants; Antipyrine; Dose-Response Relationship, Drug; Edaravone; Epilepsy, Temporal Lobe; Free Radical Scavengers; Kindling, Neurologic; Male; Rats; Rats, Wistar | 2009 |
Does the concomitant intra-arterial injection of asialoerythropoietin and edaravone mitigate ischaemic mucosal damage after acute superior mesenteric artery thromboembolism in a rabbit autologous fibrin clot model?
Topics: Animals; Antipyrine; Asialoglycoproteins; Catheterization; Disease Models, Animal; Drug Combinations; Edaravone; Erythropoietin; Fibrin; Fibrinolytic Agents; Free Radical Scavengers; Heparin; Injections, Intra-Arterial; Intestinal Mucosa; Mesenteric Artery, Superior; Mesenteric Vascular Occlusion; Rabbits; Random Allocation; Reperfusion Injury; Survival Rate; Thromboembolism; Urokinase-Type Plasminogen Activator | 2010 |
[Effects of edaravone on IRE1 mRNA expression and neuronal apoptosis in the hippocampus of rats with status convulsivus].
Topics: Animals; Antipyrine; Apoptosis; Disease Models, Animal; Edaravone; Hippocampus; In Situ Nick-End Labeling; Male; Membrane Proteins; Neurons; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Status Epilepticus | 2009 |
[Edaravone protects hearing from acute acoustic trauma in guinea pigs].
Topics: Animals; Antipyrine; Auditory Threshold; Cochlea; Ear, Middle; Edaravone; Female; Free Radical Scavengers; Guinea Pigs; Hearing Loss, Noise-Induced; Oxidative Stress; Reactive Oxygen Species | 2009 |
The novel free radical scavenger, edaravone, increases neural stem cell number around the area of damage following rat traumatic brain injury.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult Stem Cells; Aldehydes; Animals; Antipyrine; Behavior, Animal; Brain Injuries; Cell Count; Cell Differentiation; Cell Proliferation; Cells, Cultured; Deoxyguanosine; Disease Models, Animal; DNA, Single-Stranded; Edaravone; ELAV Proteins; Free Radical Scavengers; Linear Models; Lipid Peroxidation; Male; Nerve Tissue Proteins; Neurons; Rats; Rats, Wistar; Statistics, Nonparametric; Time Factors | 2009 |
Changes of expression of glucose transporters in the fetal lamb brain after MCI-186 administration to the maternal circulation with 10-min persistent umbilical cord occlusion.
Topics: Animals; Antipyrine; Arterial Occlusive Diseases; Brain; Drug Evaluation, Preclinical; Edaravone; Female; Fetus; Free Radical Scavengers; Glucose Transport Proteins, Facilitative; Hypoxia-Ischemia, Brain; Injections, Intravenous; Maternal-Fetal Exchange; Neuroprotective Agents; Placental Circulation; Pregnancy; Reperfusion Injury; Sheep; Time Factors; Umbilical Cord | 2009 |
Effect of the free radical scavenger edaravone on peripheral nerve ischemia-reperfusion injury.
Topics: Animals; Antipyrine; Behavior, Animal; Edaravone; Edema; Electrophysiology; Free Radical Scavengers; Male; Nerve Degeneration; Nerve Fibers; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury | 2009 |
Poly(ADP-ribose) polymerase-1 modulation of in vivo response of brain hypoxia-inducible factor-1 to hypoxia/reoxygenation is mediated by nitric oxide and factor inhibiting HIF.
Topics: Analysis of Variance; Animals; Antipyrine; Brain; Disease Models, Animal; Edaravone; Enzyme Inhibitors; Excitatory Amino Acid Transporter 2; Free Radical Scavengers; Gene Expression Regulation; Hypoxia; Hypoxia-Inducible Factor 1; Isoquinolines; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Oxidative Stress; Oxygen; Piperidines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; RNA, Messenger; Thiobarbituric Acid Reactive Substances | 2009 |
Protective effects of the free radical scavenger edaravone against glutamate neurotoxicity in nearly pure neuronal culture.
Topics: Animals; Antipyrine; Apoptosis; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Edaravone; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Free Radical Scavengers; Glutamic Acid; Necrosis; Neuroglia; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Reactive Oxygen Species | 2009 |
Protective effect of edaravone, a free-radical scavenger, on ischaemia-reperfusion injury in the rat testis.
Topics: Animals; Antipyrine; Edaravone; Free Radical Scavengers; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Spermatic Cord Torsion; Testis | 2010 |
Anterior spinal artery as a collateral channel in patients with acute bilateral vertebral artery occlusions. Two case reports.
Topics: Acute Disease; Aged; Antipyrine; Arginine; Brain Stem; Cerebellum; Cerebral Revascularization; Cerebrovascular Circulation; Circle of Willis; Coma; Disease Progression; Edaravone; Free Radical Scavengers; Functional Laterality; Humans; Male; Middle Aged; Pipecolic Acids; Platelet Aggregation Inhibitors; Recovery of Function; Respiratory Insufficiency; Sulfonamides; Treatment Outcome; Vertebral Artery; Vertebrobasilar Insufficiency | 2009 |
Edaravone inhibits protein carbonylation by a direct carbonyl-scavenging mechanism: focus on reactivity, selectivity, and reaction mechanisms.
Topics: Aldehydes; Antipyrine; Chromatography, High Pressure Liquid; Edaravone; Free Radical Scavengers; Glycation End Products, Advanced; Hemoglobins; Molecular Dynamics Simulation; Protein Carbonylation; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2010 |
Edaravone attenuates cerebral ischemic injury by suppressing aquaporin-4.
Topics: Animals; Antipyrine; Aquaporin 4; Brain Edema; Brain Ischemia; Disease Models, Animal; Edaravone; Free Radical Scavengers; Male; Rats | 2009 |
Edaravone protects against apoptotic neuronal cell death and improves cerebral function after traumatic brain injury in rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Antipyrine; Apoptosis; Behavior, Animal; Brain Injuries; Deoxyguanosine; DNA, Single-Stranded; Edaravone; ELAV Proteins; Free Radical Scavengers; Glial Fibrillary Acidic Protein; Maze Learning; Rats; Rats, Wistar | 2010 |
Neuroprotective effects of edaravone on early brain injury in rats after subarachnoid hemorrhage.
Topics: Animals; Antipyrine; Blotting, Western; Brain Injuries; Edaravone; Immunohistochemistry; Male; Malondialdehyde; Neuroprotective Agents; Random Allocation; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Superoxide Dismutase | 2009 |
Edaravone, a free radical scavenger, protects components of the neurovascular unit against oxidative stress in vitro.
Topics: Analysis of Variance; Animals; Animals, Newborn; Antipyrine; Astrocytes; Brain-Derived Neurotrophic Factor; Cell Death; Cerebral Cortex; Dose-Response Relationship, Drug; Edaravone; Endothelial Cells; Enzyme-Linked Immunosorbent Assay; Free Radical Scavengers; Glutamic Acid; Hippocampus; Humans; Hydrogen Peroxide; L-Lactate Dehydrogenase; Mice; Neurons; Nitric Oxide Donors; Nitroprusside; Oxidative Stress; Rats; Rats, Sprague-Dawley | 2010 |
Small temperature variations alter edaravone-induced neuroprotection of cortical cultures exposed to prolonged hypoxic episodes.
Topics: Animals; Antipyrine; Cell Hypoxia; Cell Survival; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Edaravone; Free Radical Scavengers; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Temperature | 2010 |
[Effects of edaravone on the expression of interleukin-1beta, nuclear factor-kappaB and neuron apoptosis in juvenile rat hippocampus after status convulsion].
Topics: Animals; Antipyrine; Apoptosis; Edaravone; Hippocampus; Interleukin-1beta; Male; Neurons; NF-kappa B; Rats; Rats, Sprague-Dawley; Seizures | 2009 |
Edaravone improves the expression of nerve growth factor in human astrocytes subjected to hypoxia/reoxygenation.
Topics: Antipyrine; Astrocytes; Blotting, Western; Cell Hypoxia; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Edaravone; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Free Radical Scavengers; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Nerve Growth Factor; Oxygen; Phosphorylation; Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors | 2010 |
Repeated edaravone treatment reduces oxidative cell damage in rat brain induced by middle cerebral artery occlusion.
Topics: Animals; Antioxidants; Antipyrine; Biomarkers; Brain; Brain Ischemia; Edaravone; Free Radical Scavengers; Humans; Infarction, Middle Cerebral Artery; Male; Molecular Structure; Neuropsychological Tests; Oleic Acid; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Sprague-Dawley | 2009 |
Protective effects of the free radical scavenger edaravone on acute pancreatitis-associated lung injury.
Topics: Acute Lung Injury; Animals; Antipyrine; Disease Models, Animal; Edaravone; Free Radical Scavengers; Male; Pancreatitis; Protective Agents; Random Allocation; Rats; Rats, Sprague-Dawley | 2010 |
[The protective effect of edaravone on the treatment of sepsis in rats].
Topics: Animals; Antipyrine; Disease Models, Animal; Edaravone; Free Radical Scavengers; Lung; Random Allocation; Rats; Rats, Sprague-Dawley; Sepsis | 2009 |
Edaravone, a known free radical scavenger, enhances X-ray-induced apoptosis at low concentrations.
Topics: Antipyrine; Apoptosis; Cell Line, Tumor; Dose-Response Relationship, Drug; Edaravone; Free Radical Scavengers; Gene Knockdown Techniques; Hep G2 Cells; Humans; Leukemia, T-Cell; Radiation-Sensitizing Agents; Reactive Oxygen Species; Transfection; Tumor Cells, Cultured; Tumor Suppressor Protein p53; X-Rays | 2010 |
Effect of edaravone on ischemia/reperfusion injury in rat urinary bladder--changes in smooth muscle cell phenotype and contractile function.
Topics: Animals; Antipyrine; Dose-Response Relationship, Drug; Edaravone; Electric Stimulation; Free Radical Scavengers; In Vitro Techniques; Isometric Contraction; Male; Microscopy, Electron; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Urinary Bladder | 2010 |
A novel administration route of edaravone--II: mucosal absorption of edaravone from edaravone/hydroxypropyl-beta-cyclodextrin complex solution including L-cysteine and sodium hydrogen sulfite.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Absorption; Administration, Oral; Administration, Rectal; Animals; Antipyrine; beta-Cyclodextrins; Cysteine; Edaravone; Male; Mouth Mucosa; Pharmaceutical Solutions; Rats; Rats, Wistar; Rectum; Sulfites | 2010 |
Does functional outcome in acute ischaemic stroke patients correlate with the amount of free-radical scavenger treatment? A retrospective study of edaravone therapy.
Topics: Aged; Aged, 80 and over; Antipyrine; Cerebral Infarction; Dose-Response Relationship, Drug; Edaravone; Free Radical Scavengers; Humans; Japan; Length of Stay; Recovery of Function; Rehabilitation Centers; Retrospective Studies; Severity of Illness Index; Treatment Outcome | 2010 |
Gene network analysis to determine the effects of antioxidant treatment in a rat model of neonatal hypoxic-ischemic encephalopathy.
Topics: Animals; Animals, Newborn; Antioxidants; Antipyrine; Disease Models, Animal; Edaravone; Female; Free Radical Scavengers; Gene Regulatory Networks; Hypoxia-Ischemia, Brain; Neuroprotective Agents; Oligonucleotide Array Sequence Analysis; Pregnancy; Rats; Rats, Wistar | 2010 |
[Protection of edaravone on neurons and its effects on the expression of interleukin-lbeta in juvenile rat hippocampus following status convulsion].
Topics: Animals; Antipyrine; Edaravone; Hippocampus; Immunohistochemistry; In Situ Nick-End Labeling; Interleukin-1beta; Male; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2010 |
Edaravone directly reacts with singlet oxygen and protects cells from attack.
Topics: Animals; Antipyrine; Cell Death; Cell Line; Cell-Free System; Chromatography, High Pressure Liquid; Edaravone; Free Radical Scavengers; Microscopy, Confocal; Neurons; Oxidation-Reduction; Oxidative Stress; Rats; Rose Bengal; Singlet Oxygen; Spectrometry, Fluorescence | 2010 |
[A comparative study on the protection effect of nerve growth factor and edaravone pretreatment against cerebral ischemia/reperfusion injury].
Topics: Animals; Animals, Newborn; Antipyrine; Apoptosis; Brain Ischemia; Cells, Cultured; Disease Models, Animal; Edaravone; Free Radical Scavengers; Nerve Growth Factor; Neurons; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2010 |
[Effect of edaravone on extracellular signal-regulated kinase 1/2 pathway following severe traumatic brain injury in rats].
Topics: Animals; Antipyrine; Apoptosis; Brain Injuries; Disease Models, Animal; Edaravone; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurons; Rats; Rats, Sprague-Dawley; Signal Transduction | 2010 |
A novel method for inducing focal ischemia in vitro.
Topics: Animals; Antipyrine; Brain Ischemia; Cell Hypoxia; Cell Survival; Culture Media; Edaravone; Excitatory Postsynaptic Potentials; Glucose; Male; Membrane Potentials; Models, Neurological; Neurons; Neuroprotective Agents; Oxygen; Patch-Clamp Techniques; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Time Factors; Tissue Culture Techniques | 2010 |
A novel rodent model of reperfusion injury following occlusion of the middle cerebral artery.
Topics: Animals; Antipyrine; Cerebrovascular Circulation; Disease Models, Animal; Dose-Response Relationship, Drug; Edaravone; Estrogens; Infarction, Middle Cerebral Artery; Male; Middle Cerebral Artery; Neuroprotective Agents; Neurosurgical Procedures; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Reperfusion Injury; Reproducibility of Results; Time Factors | 2010 |
Pharmacokinetic interaction between puerarin and edaravone, and effect of borneol on the brain distribution kinetics of puerarin in rats.
Topics: Animals; Antioxidants; Antipyrine; Brain; Camphanes; Chromatography, High Pressure Liquid; Drug Interactions; Drugs, Chinese Herbal; Edaravone; Free Radical Scavengers; Half-Life; Isoflavones; Limit of Detection; Male; Metabolic Clearance Rate; Microdialysis; Random Allocation; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution | 2010 |
Systemic administration of a free radical scavenger, edaravone, protects against light-induced photoreceptor degeneration in the mouse retina.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antipyrine; Cell Death; Deoxyguanosine; Edaravone; Electrophysiological Phenomena; Electroretinography; Free Radical Scavengers; In Situ Nick-End Labeling; Light; Male; Mice; Mitogen-Activated Protein Kinases; Phosphorylation; Photoreceptor Cells, Vertebrate | 2010 |
Scavenging free radicals improves endothelial dysfunction in human coronary arteries in vivo.
Topics: Acetylcholine; Aged; Aldehydes; Antipyrine; Blood Flow Velocity; Coronary Angiography; Coronary Circulation; Coronary Vessels; Dose-Response Relationship, Drug; Echocardiography, Doppler; Edaravone; Endothelium, Vascular; Female; Free Radical Scavengers; Free Radicals; Humans; Infusions, Intra-Arterial; Isosorbide Dinitrate; Japan; Male; Malondialdehyde; Nitric Oxide; Oxidative Stress; Vasodilation; Vasodilator Agents | 2010 |
1-(3'-[125I]Iodophenyl)-3-methy-2-pyrazolin-5-one: preparation, solution stability, and biodistribution in normal mice.
Topics: Animals; Antioxidants; Antipyrine; Drug Stability; Edaravone; Male; Mice; Mice, Inbred ICR; Molecular Structure; Pyrazolones; Solubility; Tissue Distribution | 2010 |
Edaravone: a new therapeutic approach for the treatment of acute stroke.
Topics: Animals; Antipyrine; Edaravone; Free Radical Scavengers; Humans; Neuroprotective Agents; Rats; Stroke; Tissue Plasminogen Activator | 2010 |
Lysosomal degradation of the carboxydextran shell of coated superparamagnetic iron oxide nanoparticles and the fate of professional phagocytes.
Topics: Animals; Antipyrine; Apoptosis; Dextrans; Edaravone; Free Radical Scavengers; Humans; Intracellular Space; Kinetics; Kupffer Cells; Liver; Lysosomes; Magnetic Resonance Imaging; Magnetite Nanoparticles; Mice; Nanoparticles; Phagocytes; Reactive Oxygen Species; Tumor Necrosis Factor-alpha | 2010 |
A free-radical scavenger protects the neural progenitor cells in the dentate subgranular zone of the hippocampus from cell death after X-irradiation.
Topics: Animals; Antipyrine; Apoptosis; Cells, Cultured; Dentate Gyrus; Edaravone; Free Radical Scavengers; Male; Maze Learning; Mice; Mice, Inbred C57BL; Neural Stem Cells; Neurogenesis; Radiation Injuries, Experimental | 2010 |
The antioxidant edaravone attenuates ER-stress-mediated cardiac apoptosis and dysfunction in rats with autoimmune myocarditis.
Topics: Animals; Antioxidants; Antipyrine; Apoptosis; Autoimmune Diseases; Disease Models, Animal; Down-Regulation; Drug Evaluation, Preclinical; Edaravone; Endoplasmic Reticulum; Heart; Male; Myocarditis; Myocardium; Rats; Rats, Inbred Lew; Stress, Physiological; Unfolded Protein Response; Ventricular Dysfunction, Left | 2010 |
Free radical scavenger edaravone administration protects against tissue plasminogen activator induced oxidative stress and blood brain barrier damage.
Topics: Acetylglucosamine; Animals; Antipyrine; Blood-Brain Barrier; Brain Injuries; Cerebral Cortex; Collagen Type IV; Disease Models, Animal; Drug Interactions; Edaravone; Endothelial Cells; Fibrinolytic Agents; Free Radical Scavengers; Gene Expression Regulation; In Vitro Techniques; Lipid Peroxidation; Male; Membrane Proteins; Nerve Tissue Proteins; Occludin; Oxidative Stress; Rats; Rats, Wistar; Tissue Plasminogen Activator | 2010 |
Protective effect of edaravone against renal ischemia/reperfusion injury and compared with ischemic postconditioning in rats.
Topics: Animals; Antipyrine; Apoptosis; bcl-2-Associated X Protein; Blood Urea Nitrogen; Creatinine; Edaravone; Free Radical Scavengers; Ischemic Postconditioning; Kidney; Male; Malondialdehyde; Proto-Oncogene Proteins c-bcl-2; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase | 2010 |
Edaravone, a free radical scavenger, promotes engraftment of intraportally transplanted islet cells.
Topics: Animals; Antipyrine; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Edaravone; Free Radical Scavengers; Glucose Tolerance Test; Graft Survival; In Situ Nick-End Labeling; Insulin; Islets of Langerhans Transplantation; Liver; Male; Rats; Rats, Inbred F344 | 2011 |
Edaravone, a novel antidote against lung injury and pulmonary fibrosis induced by paraquat?
Topics: Animals; Antidotes; Antipyrine; Bronchoalveolar Lavage Fluid; Edaravone; Herbicides; Hydroxyproline; Lung; Lung Injury; Male; Paraquat; Pulmonary Fibrosis; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2011 |
Synthesis, antitumor activity and QSAR studies of some 4-aminomethylidene derivatives of edaravone.
Topics: Antineoplastic Agents; Antipyrine; Breast Neoplasms; Cell Line, Tumor; Drug Screening Assays, Antitumor; Edaravone; Female; Free Radical Scavengers; Humans; Quantitative Structure-Activity Relationship | 2011 |
Effect of a free radical scavenger, edaravone, on free radical reactions: related signal transduction and cerebral vasospasm in the rabbit subarachnoid hemorrhage model.
Topics: Animals; Antipyrine; Basilar Artery; Disease Models, Animal; Edaravone; Free Radical Scavengers; Gene Expression Regulation, Enzymologic; Injections, Intravenous; Rabbits; rho-Associated Kinases; Subarachnoid Hemorrhage; Vasospasm, Intracranial | 2011 |
Pulse radiolysis study on free radical scavenger edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one). 2: A comparative study on edaravone derivatives.
Topics: Antipyrine; Computer Simulation; Edaravone; Free Radical Scavengers; Hydroxyl Radical; Models, Chemical; Nitrogen; Pulse Radiolysis | 2011 |
Effects of continuous intravenous infusion of MCI-186 on functional recovery after spinal cord injury in rats.
Topics: Animals; Antipyrine; Disease Models, Animal; Drug Administration Schedule; Edaravone; Free Radical Scavengers; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Recovery of Function; Spinal Cord; Spinal Cord Injuries; Time Factors; Treatment Outcome | 2011 |
[ERK1/2 mediates edaravone-triggered protection against myocardial damage induced by isoprenaline in H9c2 cells].
Topics: Animals; Antipyrine; Cell Line; Edaravone; Flavonoids; Isoproterenol; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Myocytes, Cardiac; Phosphorylation; Rats | 2010 |
Donor antioxidant strategy prolongs cardiac allograft survival by attenuating tissue dendritic cell immunogenicity(†).
Topics: Animals; Antioxidants; Antipyrine; Dendritic Cells; Edaravone; Free Radical Scavengers; Graft Rejection; Graft Survival; Heart Transplantation; Lymphoid Tissue; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Oxidative Stress; Time Factors; Tissue Donors; Transplantation, Homologous | 2011 |
OH radical scavenging activity of Edaravone: mechanism and kinetics.
Topics: Antipyrine; Diffusion; Edaravone; Electron Transport; Free Radical Scavengers; Hydrogen-Ion Concentration; Hydroxyl Radical; Kinetics; Thermodynamics | 2011 |
Effects of edaravone, a free radical scavenger, on serum levels of inflammatory biomarkers in acute brain infarction.
Topics: Acute Disease; Aged; Aged, 80 and over; Analysis of Variance; Antipyrine; Biomarkers; Brain Infarction; C-Reactive Protein; Chi-Square Distribution; Edaravone; Female; Free Radical Scavengers; Humans; Inflammation Mediators; Infusions, Intravenous; Interleukins; Japan; Linear Models; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Middle Aged; Prospective Studies; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2012 |
Towards a selected reaction monitoring mass spectrometry fingerprint approach for the screening of oligosaccharidoses.
Topics: Antipyrine; Chromatography, High Pressure Liquid; Edaravone; Fucosidosis; Glycogen Storage Disease Type II; Humans; Lysosomal Storage Diseases; Mannosidase Deficiency Diseases; Mucolipidoses; Oligosaccharides; Tandem Mass Spectrometry | 2011 |
Edaravone and carnosic acid synergistically enhance the expression of nerve growth factor in human astrocytes under hypoxia/reoxygenation.
Topics: Abietanes; Antioxidants; Antipyrine; Astrocytes; Cell Survival; Cells, Cultured; Drug Synergism; Edaravone; Enzyme-Linked Immunosorbent Assay; Extracellular Signal-Regulated MAP Kinases; Humans; Hypoxia-Ischemia, Brain; Immunoblotting; JNK Mitogen-Activated Protein Kinases; Nerve Growth Factor; Plant Extracts; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction | 2011 |
Edaravone alleviates delayed neuronal death and long-dated cognitive dysfunction of hippocampus after transient focal ischemia in Wistar rat brains.
Topics: Animals; Antipyrine; Brain Ischemia; Cognition Disorders; Disease Models, Animal; Edaravone; Free Radical Scavengers; Hippocampus; Male; Nerve Degeneration; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar | 2011 |
Effects of edaravone on a rat model of punch-drunk syndrome.
Topics: Animals; Antipyrine; Athletic Injuries; Avoidance Learning; Boxing; Brain Concussion; Brain Injury, Chronic; Cerebellum; Cerebral Cortex; Corpus Callosum; Disease Models, Animal; Edaravone; Fear; Free Radical Scavengers; Hippocampus; Memory, Short-Term; Rats; Rats, Inbred Strains; Rats, Wistar; Syndrome; Vibration | 2011 |
Feasibility study for functional test battery of SOD transgenic rat (H46R) and evaluation of edaravone, a free radical scavenger.
Topics: Amyotrophic Lateral Sclerosis; Animals; Antipyrine; Disease Models, Animal; Edaravone; Feasibility Studies; Female; Free Radical Scavengers; Male; Movement Disorders; Predictive Value of Tests; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Recovery of Function; Reproducibility of Results; Superoxide Dismutase; Superoxide Dismutase-1; Time Factors | 2011 |
Iron mediates N-methyl-D-aspartate receptor-dependent stimulation of calcium-induced pathways and hippocampal synaptic plasticity.
Topics: Acetylcysteine; Animals; Antipyrine; Calcium; Calcium Channels, L-Type; Calcium Signaling; Cells, Cultured; Edaravone; Enzyme Activation; Excitatory Amino Acid Agonists; Free Radical Scavengers; Hippocampus; Iron; Iron Chelating Agents; Long-Term Potentiation; Mitogen-Activated Protein Kinase 3; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Ryanodine Receptor Calcium Release Channel; Synapses; Synaptic Transmission | 2011 |
Edaravone-loaded liposomes for retinal protection against oxidative stress-induced retinal damage.
Topics: Animals; Antipyrine; Cell Line; Drug Compounding; Drug Delivery Systems; Edaravone; Excitatory Amino Acid Agonists; Eye; Free Radical Scavengers; Intravitreal Injections; Liposomes; Male; Mice; Molecular Targeted Therapy; N-Methylaspartate; Oxidative Stress; Phospholipids; Protective Agents; Retina; Retinal Diseases | 2011 |
Edaravone, an ROS scavenger, ameliorates photoreceptor cell death after experimental retinal detachment.
Topics: Aldehydes; Animals; Antipyrine; Blotting, Western; Caspases; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Edaravone; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique, Indirect; Free Radical Scavengers; In Situ Nick-End Labeling; Oxidative Stress; Photoreceptor Cells, Vertebrate; Protein Carbonylation; Rats; Rats, Inbred BN; Reactive Oxygen Species; Retinal Detachment | 2011 |
C/EBP homologous protein deficiency attenuates myocardial reperfusion injury by inhibiting myocardial apoptosis and inflammation.
Topics: Animals; Antipyrine; Apoptosis; Cells, Cultured; Chemokines; Cytokines; Disease Models, Animal; DNA-Binding Proteins; Edaravone; Endoplasmic Reticulum; Free Radical Scavengers; Gene Expression Regulation; Inflammation; Inflammation Mediators; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Reperfusion Injury; Myocardium; Regulatory Factor X Transcription Factors; RNA Splicing; RNA, Messenger; Stress, Physiological; Superoxides; Thapsigargin; Time Factors; Transcription Factor CHOP; Transcription Factors | 2011 |
[Development of a new HPLC technique for analyzing monosaccharide composition and its application in the quality control of Silybum marianum polysaccharide].
Topics: Antipyrine; Arabinose; Chromatography, High Pressure Liquid; Edaravone; Galactose; Glucose; Glucuronic Acid; Hexuronic Acids; Mannose; Monosaccharides; Plants, Medicinal; Polysaccharides; Quality Control; Rhamnose; Seeds; Silybum marianum; Spectrophotometry, Ultraviolet; Xylose | 2010 |
Montelukast, a cysteinyl leukotriene receptor-1 antagonist, attenuates chronic brain injury after focal cerebral ischaemia in mice and rats.
Topics: Acetates; Administration, Oral; Animals; Antipyrine; Atrophy; Behavior, Animal; Brain Injury, Chronic; Chromones; Cyclopropanes; Disease Models, Animal; Drug Evaluation, Preclinical; Edaravone; Free Radical Scavengers; Infarction, Middle Cerebral Artery; Injections, Intraperitoneal; Leukotriene Antagonists; Male; Mice; Mice, Inbred ICR; Nerve Degeneration; Quinolines; Rats; Rats, Sprague-Dawley; Sulfides | 2011 |
Edaravone, a hydroxyl radical scavenger, ameliorates the severity of pulmonary hypertension in a porcine model of neonatal sepsis.
Topics: Animals; Antipyrine; Blood Pressure; Edaravone; Free Radical Scavengers; Humans; Hydroxyl Radical; Hypertension, Pulmonary; Infant, Newborn; Infant, Newborn, Diseases; Sepsis; Swine; Tumor Necrosis Factor-alpha | 2011 |
Stroke in a child safely treated with intravenous tissue plasminogen activator and edaravone, a free radical scavenger.
Topics: Antipyrine; Brain Ischemia; Child; Disability Evaluation; Drug Therapy, Combination; Edaravone; Female; Fibrinolytic Agents; Free Radical Scavengers; Humans; Infusions, Intravenous; Magnetic Resonance Imaging; Stroke; Thrombolytic Therapy; Tissue Plasminogen Activator; Treatment Outcome; Ultrasonography, Doppler, Color; Ultrasonography, Doppler, Transcranial | 2012 |
[Effects of edaravone on glial fibrillary acidic protein and interleukin-lβ expression and neuronal apoptosis in juvenile rat hippocampus after status convulsion].
Topics: Animals; Antipyrine; Apoptosis; Edaravone; Free Radical Scavengers; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; In Situ Nick-End Labeling; Interleukin-1beta; Male; Neurons; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures | 2011 |
[Effects of edaravone on the expression of GRP78, Caspase-12, and neuron apoptosis in juvenile rat hippocampus after status convulsive].
Topics: Animals; Antipyrine; Apoptosis; Caspase 12; Edaravone; Heat-Shock Proteins; Hippocampus; Male; Rats; Rats, Sprague-Dawley; Seizures | 2011 |
New treatment of free-radical scavenger in adrenoleukodystrophy.
Topics: Adrenoleukodystrophy; Antipyrine; Child; Edaravone; Evoked Potentials, Somatosensory; Free Radical Scavengers; Humans; Male; Neurons; Reactive Oxygen Species; Synaptic Transmission; Upper Extremity | 2011 |
Translational stroke research of the combination of thrombolysis and antioxidant therapy.
Topics: Antioxidants; Antipyrine; Biomarkers; Edaravone; Fibrinolytic Agents; Humans; Nitrogen Oxides; Oxidative Stress; Stroke; Thrombolytic Therapy; Tissue Plasminogen Activator; Treatment Outcome; Uric Acid | 2011 |
Edaravone ameliorates diabetes-induced dysfunction of NO-induced relaxation in corpus cavernosum smooth muscle in the rat.
Topics: Animals; Antipyrine; Blood Glucose; Cyclic GMP; Diabetes Mellitus, Experimental; Edaravone; Free Radical Scavengers; Impotence, Vasculogenic; Male; Malondialdehyde; Muscle, Smooth, Vascular; Nitric Oxide; Penis; Rats; Rats, Wistar; Reactive Oxygen Species; Vasodilation | 2011 |
A somatostatin analogue, octreotide, ameliorates intestinal ischemia-reperfusion injury through the early induction of heme oxygenase-1.
Topics: Animals; Antipyrine; Edaravone; Enzyme Inhibitors; Free Radical Scavengers; Heme Oxygenase-1; Intestine, Large; Male; Metalloporphyrins; Models, Animal; Octreotide; Protoporphyrins; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Reperfusion Injury; Somatostatin | 2012 |
Comparison of polysaccharides from different Dendrobium using saccharide mapping.
Topics: Antipyrine; Chemistry, Pharmaceutical; Chromatography; Chromatography, Gel; Chromatography, High Pressure Liquid; Dendrobium; Drugs, Chinese Herbal; Edaravone; Enzymes; Mass Spectrometry; Plant Extracts; Polysaccharides; Powders; Quality Control; Technology, Pharmaceutical | 2011 |
Neuroprotective mechanisms of SMTP-7 in cerebral infarction model in mice.
Topics: Aldehydes; Animals; Antipyrine; Benzopyrans; Brain; Cerebral Infarction; Disease Models, Animal; Edaravone; Ferrous Compounds; Free Radical Scavengers; Gene Expression; Lipid Peroxidation; Male; Mice; Mice, Inbred Strains; NADPH Oxidases; Neuroprotective Agents; Pyrrolidinones; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Thiobarbituric Acid Reactive Substances; Tissue Plasminogen Activator | 2011 |
In vivo optical imaging for evaluating the efficacy of edaravone after transient cerebral ischemia in mice.
Topics: Animals; Annexin A5; Antipyrine; Apoptosis; Autophagy; Blood-Brain Barrier; Blotting, Western; Cerebral Infarction; Diagnostic Imaging; Edaravone; Fluorescence; Fluorescent Antibody Technique; Fluorescent Antibody Technique, Indirect; Free Radical Scavengers; Immunohistochemistry; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Male; Matrix Metalloproteinases; Mice; Mice, Inbred ICR | 2011 |
The specific free radical scavenger edaravone suppresses fibrosis in the bleomycin-induced and tight skin mouse models of systemic sclerosis.
Topics: Animals; Antipyrine; Bleomycin; Disease Models, Animal; Edaravone; Fibrosis; Free Radical Scavengers; Mice; Pulmonary Fibrosis; Scleroderma, Systemic; Skin; Treatment Outcome | 2011 |
[Separation of 1-phenyl-3-methyl-5-pyrazolone derivatives of traditional Chinese medicine oligosaccharides by capillary zone electrophoresis].
Topics: Antipyrine; Drugs, Chinese Herbal; Edaravone; Electrophoresis, Capillary; Oligosaccharides | 2011 |
Edaravone guards dopamine neurons in a rotenone model for Parkinson's disease.
Topics: Animals; Antipyrine; bcl-2-Associated X Protein; Behavior, Animal; Dopamine; Edaravone; Free Radical Scavengers; Freezing Reaction, Cataleptic; Humans; Male; Neurons; Neuroprotective Agents; Neuropsychological Tests; Parkinsonian Disorders; Rats; Rats, Wistar; Reactive Oxygen Species; Rotenone; Uncoupling Agents; Vesicular Monoamine Transport Proteins | 2011 |
Striatal neuroprotection from neonatal hypoxia-ischemia in piglets by antioxidant treatment with EUK-134 or edaravone.
Topics: Animals; Animals, Newborn; Antioxidants; Antipyrine; Corpus Striatum; Edaravone; Free Radical Scavengers; Hypoxia-Ischemia, Brain; Nerve Degeneration; Neuroprotective Agents; Organometallic Compounds; Oxidative Stress; Salicylates; Swine | 2011 |
Free-radical scavenger edaravone treatment confers neuroprotection against traumatic brain injury in rats.
Topics: Animals; Antipyrine; Apoptosis; Astrocytes; Blood-Brain Barrier; Body Water; Brain Injuries; Coloring Agents; Edaravone; Enzyme-Linked Immunosorbent Assay; Free Radical Scavengers; Free Radicals; Immunohistochemistry; Inflammation; Male; Microglia; Microscopy, Electron; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Sprague-Dawley | 2011 |
Edaravone offers neuroprotection in a diabetic stroke model via inhibition of endoplasmic reticulum stress.
Topics: Animals; Antipyrine; Apoptosis; Caspase 12; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; DNA Fragmentation; Edaravone; Endoplasmic Reticulum Stress; Heat-Shock Proteins; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Neuroprotective Agents; Rats; Stroke; Transcription Factor CHOP; Up-Regulation | 2012 |
Ionization energies, proton affinities, and pKa values of a large series of edaravone derivatives: implication for their free radical scavenging activity.
Topics: Antipyrine; Chemical Phenomena; Edaravone; Free Radical Scavengers; Protons | 2011 |
Optimization of monosaccharide determination using anthranilic acid and 1-phenyl-3-methyl-5-pyrazolone for gastropod analysis.
Topics: Animals; Antipyrine; Chromatography, High Pressure Liquid; Edaravone; Gastropoda; Hydrolysis; Indicators and Reagents; Monosaccharides; ortho-Aminobenzoates | 2011 |
Relative quantitation of glycans using stable isotopic labels 1-(d0/d5) phenyl-3-methyl-5-pyrazolone by mass spectrometry.
Topics: Animals; Antipyrine; Carbohydrate Sequence; Cattle; Deuterium; Edaravone; Fetuins; Humans; Isotope Labeling; Mass Spectrometry; Molecular Sequence Data; Oligosaccharides; Polysaccharides; Ribonucleases | 2011 |
Mass spectrometric O-glycan analysis after combined O-glycan release by beta-elimination and 1-phenyl-3-methyl-5-pyrazolone labeling.
Topics: Animals; Antipyrine; Carbohydrate Sequence; Cattle; Chromatography, Liquid; Dimethylamines; Edaravone; Glycomics; Humans; Hydrolysis; Mass Spectrometry; Models, Biological; Molecular Sequence Data; Mucins; Polysaccharides; Staining and Labeling; Submandibular Gland | 2012 |
Edaravone-loaded liposome eyedrops protect against light-induced retinal damage in mice.
Topics: Animals; Antipyrine; Cell Line; Drug Delivery Systems; Edaravone; Electroretinography; Free Radical Scavengers; Humans; In Situ Nick-End Labeling; Light; Liposomes; Mice; Ophthalmic Solutions; Radiation Injuries, Experimental; Reactive Oxygen Species; Retina; Retinal Degeneration | 2011 |
Singlet oxygen is essential for neutrophil extracellular trap formation.
Topics: Antipyrine; Cells, Cultured; Dihematoporphyrin Ether; Edaravone; Free Radical Scavengers; Granulomatous Disease, Chronic; Humans; Neutrophils; Singlet Oxygen; Tetradecanoylphorbol Acetate | 2011 |
New method for absolute spinal cord ischemia protection in rabbits.
Topics: Animals; Antipyrine; Aorta; Biomarkers; Combined Modality Therapy; Constriction; Disease Models, Animal; Edaravone; Free Radical Scavengers; Hypothermia, Induced; Infusions, Intra-Arterial; Malondialdehyde; Motor Neurons; Neurologic Examination; Neuroprotective Agents; Oxidative Stress; Paraplegia; Rabbits; Reperfusion Injury; Severity of Illness Index; Spinal Cord Ischemia; Time Factors; Vascular Surgical Procedures | 2011 |
Combination of reactive oxygen species and tissue-type plasminogen activator enhances the induction of gelatinase B in brain endothelial cells.
Topics: Animals; Antipyrine; Brain; Cell Line, Transformed; Cells, Cultured; Drug Interactions; Edaravone; Endothelial Cells; Enzyme Induction; Free Radical Scavengers; Hydrogen Peroxide; I-kappa B Proteins; Matrix Metalloproteinase 9; Mice; NF-kappa B; Reactive Oxygen Species; Signal Transduction; Tissue Plasminogen Activator | 2012 |
One-pot nonreductive O-glycan release and labeling with 1-phenyl-3-methyl-5-pyrazolone followed by ESI-MS analysis.
Topics: Animals; Antipyrine; Blood Proteins; Cattle; Edaravone; Glycomics; Glycoproteins; Humans; Mucins; Polysaccharides; Proteomics; Spectrometry, Mass, Electrospray Ionization; Swine | 2011 |
Electrocardiographic and biochemical evidence for the cardioprotective effect of antioxidants in acute doxorubicin-induced cardiotoxicity in the beagle dogs.
Topics: Acute Disease; Alanine Transaminase; Animals; Antibiotics, Antineoplastic; Antioxidants; Antipyrine; Aspartate Aminotransferases; Bradycardia; Cardiotonic Agents; Creatine Kinase; Dogs; Doxorubicin; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Edaravone; Electrocardiography; Free Radical Scavengers; Heart; Heart Conduction System; Heart Diseases; Male; Random Allocation | 2011 |
Acquired platinum resistance enhances tumour angiogenesis through angiotensin II type 1 receptor in bladder cancer.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antipyrine; Cell Line, Tumor; Cisplatin; Drug Resistance, Neoplasm; Edaravone; Humans; Mice; Mice, Nude; Neovascularization, Pathologic; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Urinary Bladder Neoplasms; Vascular Endothelial Growth Factor A | 2011 |
Edaravone, a free radical scavenger, attenuates behavioral deficits following transient forebrain ischemia by inhibiting oxidative damage in gerbils.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Analysis of Variance; Animals; Antipyrine; Behavioral Symptoms; Deoxyguanosine; Disease Models, Animal; DNA Damage; Edaravone; Free Radical Scavengers; Gerbillinae; Hippocampus; In Situ Nick-End Labeling; Ischemic Attack, Transient; Lysine; Oxidative Stress; Prosencephalon; Time Factors | 2012 |
Ligation of the pterygopalatine and external carotid arteries induces ischemic damage in the murine retina.
Topics: Animals; Antipyrine; Blood Flow Velocity; Carotid Artery, External; Cell Count; Cerebrovascular Circulation; Dextrans; Disease Models, Animal; Edaravone; Electroretinography; Fluorescein Angiography; Fluorescein-5-isothiocyanate; Free Radical Scavengers; In Situ Nick-End Labeling; Laser-Doppler Flowmetry; Ligation; Male; Mice; Ophthalmic Artery; Pterygopalatine Fossa; Regional Blood Flow; Reperfusion Injury; Retinal Diseases; Retinal Ganglion Cells | 2011 |
Treatment with edaravone attenuates ischemic brain injury and inhibits neurogenesis in the subventricular zone of adult rats after focal cerebral ischemia and reperfusion injury.
Topics: Analysis of Variance; Animals; Antipyrine; Bromodeoxyuridine; Cerebral Infarction; Cerebral Ventricles; Disease Models, Animal; Doublecortin Domain Proteins; Doublecortin Protein; Edaravone; Free Radical Scavengers; Functional Laterality; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Infarction, Middle Cerebral Artery; Male; Microtubule-Associated Proteins; Neurogenesis; Neuropeptides; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Time Factors; Vascular Endothelial Growth Factor A | 2012 |
On the outstanding antioxidant capacity of edaravone derivatives through single electron transfer reactions.
Topics: Antioxidants; Antipyrine; Edaravone; Electron Transport; Free Radical Scavengers; Humans; Models, Theoretical; Molecular Structure | 2012 |
Modifying neurorepair and neuroregenerative factors with tPA and edaravone after transient middle cerebral artery occlusion in rat brain.
Topics: Animals; Antipyrine; Brain; Chondroitin Sulfate Proteoglycans; Edaravone; Fibrinolytic Agents; Free Radical Scavengers; GAP-43 Protein; GPI-Linked Proteins; Infarction, Middle Cerebral Artery; Male; Myelin Proteins; Netrin Receptors; Neurocan; Nogo Receptor 1; Rats; Receptors, Cell Surface; Reperfusion; Semaphorin-3A; Tissue Plasminogen Activator | 2012 |
Synthesis physicochemical profile and PAMPA study of new NO-donor edaravone co-drugs.
Topics: Animals; Antipyrine; Drug Stability; Edaravone; Humans; Nitrates; Nitric Oxide Donors; Nitrites; Permeability; Rats; Vasodilator Agents | 2012 |
Glucuronidation of edaravone by human liver and kidney microsomes: biphasic kinetics and identification of UGT1A9 as the major UDP-glucuronosyltransferase isoform.
Topics: Androsterone; Antipyrine; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Edaravone; Estradiol; Glucuronides; Glucuronosyltransferase; Humans; Isoenzymes; Kidney; Kinetics; Metabolic Clearance Rate; Microsomes; Microsomes, Liver; Molecular Structure; Naloxone; Propofol; Tandem Mass Spectrometry; UDP-Glucuronosyltransferase 1A9 | 2012 |
Edaravone attenuates impairment of synaptic plasticity in granule cell layer of the dentate gyrus following traumatic brain injury.
Topics: Animals; Antipyrine; Brain Injuries; Dentate Gyrus; Edaravone; Electric Stimulation; Excitatory Postsynaptic Potentials; Free Radical Scavengers; Injections, Intraperitoneal; Long-Term Potentiation; Male; Models, Animal; Neuronal Plasticity; Nitric Oxide Donors; Rats; Rats, Wistar; Spermine; Synapses | 2011 |
Beneficial effects of edaravone, a novel antioxidant, in rats with dilated cardiomyopathy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Antipyrine; Apoptosis; Autoimmune Diseases; Blotting, Western; Cardiac Myosins; Cardiomyopathy, Dilated; Caspase 3; Cytochromes c; Down-Regulation; Edaravone; Endomyocardial Fibrosis; Endoplasmic Reticulum Stress; Heart Ventricles; In Situ Nick-End Labeling; Male; Myocarditis; NADPH Oxidases; Oxidative Stress; Rats; Rats, Inbred Lew; Swine | 2012 |
[Therapeutic time window for ischemic stroke].
Topics: Antipyrine; Cerebral Infarction; Edaravone; Fibrinolytic Agents; Free Radical Scavengers; Humans; Time Factors; Tissue Plasminogen Activator | 2011 |
Effect of edaravone on Aβ1-40 induced enhancement of voltage-gated calcium channel current.
Topics: Amyloid beta-Peptides; Analysis of Variance; Animals; Antipyrine; Cadmium Chloride; Dose-Response Relationship, Drug; Drug Interactions; Edaravone; Electric Stimulation; Free Radical Scavengers; Membrane Potentials; Patch-Clamp Techniques; PC12 Cells; Peptide Fragments; Potassium Channels, Voltage-Gated; Rats | 2012 |
Protective effects of edaravone on experimental spinal cord injury in rats.
Topics: Animals; Antipyrine; Disease Models, Animal; Edaravone; Free Radical Scavengers; Male; Methylprednisolone; Neuroprotective Agents; Random Allocation; Rats; Rats, Wistar; Spinal Cord; Spinal Cord Injuries | 2011 |
Free-radical scavenger edaravone inhibits both formation and development of abdominal aortic aneurysm in rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antipyrine; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apoptosis; Biomarkers; Calcium Chloride; Deoxyguanosine; Dilatation, Pathologic; Disease Models, Animal; Disease Progression; Drug Administration Schedule; Edaravone; Elastin; Free Radical Scavengers; Gene Expression Regulation; Immunohistochemistry; Injections, Intraperitoneal; Interleukin-1beta; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Oxidative Stress; Pancreatic Elastase; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Time Factors; Tumor Necrosis Factor-alpha | 2012 |
Role of oxidative stress in retinal photoreceptor cell death in N-methyl-N-nitrosourea-treated mice.
Topics: Alkylating Agents; Animals; Antipyrine; Cell Death; Cell Line; Cell Line, Tumor; Cells, Cultured; Edaravone; Free Radical Scavengers; Male; Methylnitrosourea; Mice; Oxidative Stress; Photoreceptor Cells, Vertebrate; Reactive Oxygen Species | 2012 |
The effect of edaravone on ischemia-reperfusion injury in rat ovary.
Topics: Animals; Antipyrine; Edaravone; Female; Free Radical Scavengers; Ovarian Diseases; Ovary; Postoperative Complications; Rats; Rats, Wistar; Reperfusion Injury; Torsion Abnormality | 2012 |
A novel flow-injection analysis system for evaluation of antioxidants by using sodium dichloroisocyanurate as a source of hypochlorite anion.
Topics: Aniline Compounds; Antioxidants; Antipyrine; Dithiothreitol; Edaravone; Flow Injection Analysis; Fluoresceins; Free Radical Scavengers; Glutathione; Hypochlorous Acid; Reactive Oxygen Species; Triazines | 2012 |
Combined effects of a neutrophil elastase inhibitor (sivelestat sodium) and a free radical scavenger (edaravone) on lipopolysaccharide-induced acute lung injury in rats.
Topics: Acute Lung Injury; Animals; Antipyrine; Drug Combinations; Edaravone; Free Radical Scavengers; Glycine; Interleukin-6; Lipopolysaccharides; Male; Malondialdehyde; Peroxidase; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Sprague-Dawley; Sulfonamides; Tumor Necrosis Factor-alpha | 2012 |
Discharge of solubilized and Dectin-1-reactive β-glucan from macrophage cells phagocytizing insoluble β-glucan particles: involvement of reactive oxygen species (ROS)-driven degradation.
Topics: Acetophenones; Acetylcysteine; Animals; Antipyrine; beta-Glucans; Cell Line; Edaravone; Enzyme-Linked Immunosorbent Assay; Humans; Lectins, C-Type; Macrophages, Peritoneal; Mice; Phagocytosis; Reactive Oxygen Species; Solubility | 2012 |
Involvement of AMPK and MAPK signaling during the progression of experimental autoimmune myocarditis in rats and its blockade using a novel antioxidant.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Antipyrine; Autoimmune Diseases; Disease Models, Animal; Disease Progression; Edaravone; Free Radical Scavengers; Heart; Isoenzymes; Male; Mitogen-Activated Protein Kinase Kinases; Myocarditis; Myocardium; Oxidative Stress; Phosphatidylinositol 3-Kinase; Phosphorylation; Protein Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Inbred Lew; Signal Transduction | 2012 |
A hypothesis: Edaravone exert cardioprotection partly via modulation of adiponectin.
Topics: Adiponectin; Antipyrine; Cardiotonic Agents; Cardiovascular Diseases; Edaravone; Free Radical Scavengers; Humans; Models, Immunological; Tumor Necrosis Factor-alpha | 2012 |
The predominance of type I oligosaccharides is a feature specific to human breast milk.
Topics: Aminopyridines; Animals; Antipyrine; Chromatography, High Pressure Liquid; Colostrum; Edaravone; Female; Humans; Infant; Lactation; Metagenome; Milk, Human; Oligosaccharides; Primates | 2012 |
[Neuroprotective effects of combined pretreatment with edaravone and propofol on neonatal rat cerebral cortical neurons with ischemia/reperfusion injury in vitro].
Topics: Animals; Antipyrine; Apoptosis; Brain Ischemia; Cell Survival; Cells, Cultured; Cerebral Cortex; Edaravone; Neurons; Neuroprotective Agents; Propofol; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2012 |
Cost-effectiveness analysis of the neuroprotective agent edaravone for noncardioembolic cerebral infarction.
Topics: Aged; Antipyrine; Cerebral Infarction; Computer Simulation; Cost Savings; Cost-Benefit Analysis; Drug Costs; Edaravone; Female; Free Radical Scavengers; Hospital Costs; Humans; Intracranial Embolism; Male; Markov Chains; Methacrylates; Models, Economic; Neuroprotective Agents; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Secondary Prevention; Time Factors; Treatment Outcome | 2013 |
Edaravone ameliorates oxidative stress associated cholinergic dysfunction and limits apoptotic response following focal cerebral ischemia in rat.
Topics: Animals; Antipyrine; Apoptosis; Basal Ganglia; Caspase 3; Choline O-Acetyltransferase; Cholinergic Neurons; Edaravone; Free Radical Scavengers; Glucosephosphate Dehydrogenase; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Male; Motor Activity; Oxidative Stress; Protein Carbonylation; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Rotarod Performance Test; Thiobarbituric Acid Reactive Substances | 2012 |
What is the role of free radical scavengers in acute stroke?
Topics: Acute Disease; Antipyrine; Biomarkers; Brain Infarction; Edaravone; Enzyme-Linked Immunosorbent Assay; Free Radical Scavengers; Humans; Inflammation Mediators; Interleukins; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Prospective Studies | 2012 |
Edaravone protects cortical neurons from apoptosis by inhibiting the translocation of BAX and Increasing the interaction between 14-3-3 and p-BAD.
Topics: 14-3-3 Proteins; Animals; Antipyrine; Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; Cell Survival; Cells, Cultured; Cerebral Cortex; Edaravone; Female; Fetus; Free Radical Scavengers; Microscopy, Electron, Transmission; Mitochondria; Neurons; Neuroprotective Agents; Pregnancy; Rats; Rats, Sprague-Dawley | 2012 |
Antioxidant treatment with edaravone or taurine ameliorates diabetes-induced testicular dysfunction in the rat.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antioxidants; Antipyrine; Deoxyguanosine; Diabetes Complications; Diabetes Mellitus, Experimental; DNA Fragmentation; Edaravone; Lipid Peroxidation; Male; Malondialdehyde; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Taurine; Testicular Diseases; Testis | 2012 |
Perfluorocarbon-facilitated CNS oxygen toxicity in rats: reversal by edaravone.
Topics: Animals; Antipyrine; Brain; Catalase; Disease Models, Animal; Drug Synergism; Edaravone; Electroencephalography; Fluorocarbons; Free Radical Scavengers; Glutathione Peroxidase; Hydrogen Peroxide; Male; Malondialdehyde; Neurotoxicity Syndromes; Nitric Oxide; Nitric Oxide Synthase; Oxygen; Random Allocation; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Time Factors | 2012 |
Edaravone inhibits apoptosis caused by ischemia/reperfusion injury in a porcine hepatectomy model.
Topics: Animals; Antipyrine; Apoptosis; Biomarkers; Cytoprotection; Disease Models, Animal; Edaravone; Free Radical Scavengers; Gene Expression Regulation; Hepatectomy; In Situ Nick-End Labeling; Liver; Liver Regeneration; Male; Real-Time Polymerase Chain Reaction; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; Swine; Time Factors | 2012 |
Density functional theory (DFT) study of edaravone derivatives as antioxidants.
Topics: Antioxidants; Antipyrine; Edaravone; Models, Chemical | 2012 |
Protective effects of MCI-186 on transplantation of bone marrow stromal cells in rat ischemic stroke model.
Topics: Analysis of Variance; Animals; Animals, Newborn; Antipyrine; Brain; Brain Infarction; Brain-Derived Neurotrophic Factor; Cell Survival; Cells, Cultured; Disease Models, Animal; Edaravone; Flow Cytometry; Free Radical Scavengers; Glucose; Hypoxia; Infarction, Middle Cerebral Artery; Magnetic Resonance Imaging; Male; Malondialdehyde; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Neurologic Examination; Neurons; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxide Dismutase; Time Factors; Vascular Endothelial Growth Factor A | 2012 |
Reactive oxygen species and the MEK/ERK pathway are involved in the toxicity of clostridium perfringens α-toxin, a prototype bacterial phospholipase C.
Topics: Animals; Antipyrine; Bacterial Toxins; Calcium-Binding Proteins; Cell Line; Clostridium perfringens; Disease Models, Animal; Edaravone; Free Radical Scavengers; Gas Gangrene; MAP Kinase Signaling System; Mice; Muscle, Skeletal; Reactive Oxygen Species; Survival Analysis; Treatment Outcome; Type C Phospholipases | 2012 |
Attenuation of axonal injury and oxidative stress by edaravone protects against cognitive impairments after traumatic brain injury.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antipyrine; Brain Injuries; Cognition; Cognition Disorders; Deoxyguanosine; Diffuse Axonal Injury; DNA Damage; Dose-Response Relationship, Drug; Edaravone; Exploratory Behavior; Free Radical Scavengers; Immunohistochemistry; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Oxidative Stress; Recognition, Psychology | 2013 |
Effect of a free radical scavenger on nitric oxide release in microvessels.
Topics: Acetylcholine; Animals; Antipyrine; Aorta, Abdominal; Disease Models, Animal; Edaravone; Free Radical Scavengers; Gene Expression Regulation, Enzymologic; Inflammation; Male; Microcirculation; Microvessels; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Up-Regulation | 2013 |
Protective effect of edaravone against Alzheimer's disease-relevant insults in neuroblastoma N2a cells.
Topics: Alzheimer Disease; Animals; Antipyrine; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Survival; Edaravone; Enzyme-Linked Immunosorbent Assay; Free Radical Scavengers; Membrane Potential, Mitochondrial; Mice; Neuroblastoma; Neuroprotective Agents; Oxidative Stress | 2012 |
Edaravone, a novel free radical scavenger, prevents steroid-induced osteonecrosis in rabbits.
Topics: Animals; Antipyrine; DNA Damage; Edaravone; Free Radical Scavengers; Glucocorticoids; Glutathione; Lipid Peroxidation; Male; Methylprednisolone; Osteonecrosis; Oxidative Stress; Rabbits; Treatment Outcome | 2013 |
Ultrasound-promoted greener synthesis of novel trifurcate 3-substituted-chroman-2,4-dione derivatives and their drug-likeness evaluation.
Topics: Aldehydes; Antineoplastic Agents; Antipyrine; Chromans; Chromones; Coumarins; Edaravone; Molecular Structure; Pyrazolones; Sound; Water | 2012 |
Aminophylline, administered at usual doses for rodents in pharmacological studies, induces hippocampal neuronal cell injury under low tidal volume hypoxic conditions in guinea-pigs.
Topics: Aminophylline; Animals; Antipyrine; CA1 Region, Hippocampal; Creatine Kinase, BB Form; Disease Models, Animal; Dose-Response Relationship, Drug; Edaravone; Free Radical Scavengers; Glutathione; Guinea Pigs; Hypoxia, Brain; Infusions, Intravenous; Lipid Peroxides; Male; Nerve Tissue Proteins; Neurons; Neurotoxicity Syndromes; Oxidative Stress; Phosphodiesterase Inhibitors; Phosphopyruvate Hydratase; Purinergic P1 Receptor Antagonists; Theophylline | 2013 |
Neurodegenerative evidence in mice brains with cecal ligation and puncture-induced sepsis: preventive effect of the free radical scavenger edaravone.
Topics: Animals; Antipyrine; Blood-Brain Barrier; Cecum; Cytokines; Edaravone; Evans Blue; Fluorescein; Free Radical Scavengers; Gene Expression Regulation; Ligation; Mice; Microscopy, Electron; NADPH Oxidases; Neurodegenerative Diseases; Nitric Oxide Synthase Type II; Phosphoproteins; Real-Time Polymerase Chain Reaction; Sepsis | 2012 |
Edaravone protects HT22 neurons from H2O2-induced apoptosis by inhibiting the MAPK signaling pathway.
Topics: Animals; Antipyrine; Apoptosis; Cell Survival; Cells, Cultured; Edaravone; Free Radical Scavengers; Hippocampus; Hydrogen Peroxide; MAP Kinase Signaling System; Mice; Neurons; Neuroprotective Agents; Reactive Oxygen Species | 2013 |
In vivo and in vitro treatment with edaravone promotes proliferation of neural progenitor cells generated following neuronal loss in the mouse dentate gyrus.
Topics: Animals; Antipyrine; Cell Proliferation; Cells, Cultured; Dentate Gyrus; Edaravone; Free Radical Scavengers; Male; Mice; Mice, Inbred Strains; Nerve Regeneration; Neurogenesis; Stem Cells | 2013 |
Separation of one-pot procedure released O-glycans as 1-phenyl-3-methyl-5-pyrazolone derivatives by hydrophilic interaction and reversed-phase liquid chromatography followed by identification using electrospray mass spectrometry and tandem mass spectromet
Topics: Animals; Antipyrine; Carbohydrate Sequence; Cattle; Chromatography, Reverse-Phase; Edaravone; Fetuins; Glycoproteins; Hydrophobic and Hydrophilic Interactions; Molecular Sequence Data; Mucins; Polysaccharides; Ranidae; Spectrometry, Mass, Electrospray Ionization; Swine | 2013 |
Effects of edaravone on amyloid-β precursor protein processing in SY5Y-APP695 cells.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Antipyrine; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Edaravone; Free Radical Scavengers; Humans; Protein Modification, Translational; Treatment Outcome | 2013 |
Edaravone ameliorates oxidative damage associated with Aβ25-35 treatment in PC12 cells.
Topics: Amyloid beta-Peptides; Animals; Antipyrine; Apoptosis; Cell Survival; Edaravone; Free Radical Scavengers; Glutathione; Lipid Peroxidation; Malondialdehyde; Mitochondria; Oxidative Stress; PC12 Cells; Peptide Fragments; Rats; Reactive Oxygen Species; Superoxide Dismutase | 2013 |
Intravenous thrombolysis with neuroprotective therapy by edaravone for ischemic stroke patients older than 80 years of age.
Topics: Adult; Aged; Aged, 80 and over; Antipyrine; Brain Ischemia; Edaravone; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Neuroprotective Agents; Retrospective Studies; Stroke; Thrombolytic Therapy; Time Factors; Tissue Plasminogen Activator; Treatment Outcome | 2013 |
[Treatment of acute ischemic stroke: tissue clock and reperfusion].
Topics: Acute Disease; Adult; Animals; Antipyrine; Brain Infarction; Edaravone; Free Radical Scavengers; Humans; Reperfusion; Time Factors; Tissue Survival | 2012 |
Effects of edaravone on the expression of β-defensin-2 mRNA in lung tissue of rats with myocardial ischemia reperfusion.
Topics: Animals; Antipyrine; beta-Defensins; Blotting, Western; Creatine Kinase; Edaravone; Gene Expression Regulation; Lung; Male; Myocardial Reperfusion Injury; Permeability; Rats; Rats, Wistar; RNA, Messenger; Tumor Necrosis Factor-alpha | 2013 |
Protective effect of edaravone for tourniquet-induced ischemia-reperfusion injury on skeletal muscle in murine hindlimb.
Topics: Animals; Antipyrine; Edaravone; Free Radical Scavengers; Hindlimb; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Reperfusion Injury; Tourniquets | 2013 |
Edaravone alleviates hypoxia-acidosis/reoxygenation-induced neuronal injury by activating ERK1/2.
Topics: Acidosis; Animals; Antipyrine; Brain Ischemia; Brain-Derived Neurotrophic Factor; Caspase 3; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Edaravone; Enzyme Activation; Glucose; Hydrogen-Ion Concentration; L-Lactate Dehydrogenase; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurons; Neuroprotective Agents; Oxygen; Primary Cell Culture; Proto-Oncogene Proteins c-bcl-2; Rats | 2013 |
Edaravone increases regional cerebral blood flow after traumatic brain injury in mice.
Topics: Animals; Antipyrine; Brain; Brain Injuries; Cerebrovascular Circulation; Disease Models, Animal; Edaravone; Free Radical Scavengers; Functional Laterality; Laser-Doppler Flowmetry; Male; Mice; Mice, Inbred C57BL; Regional Blood Flow | 2013 |
Protective effects of edaravone against cisplatin-induced hair cell damage in zebrafish.
Topics: Animals; Antipyrine; Cell Survival; Cells, Cultured; Cisplatin; Cytoprotection; Dose-Response Relationship, Drug; Edaravone; Hair Cells, Auditory; In Situ Nick-End Labeling; Microscopy, Electron, Scanning; Models, Animal; Random Allocation; Sensitivity and Specificity; Zebrafish | 2013 |
Edaravone protects against glutamate-induced PERK/EIF2α/ATF4 integrated stress response and activation of caspase-12.
Topics: Activating Transcription Factor 4; Animals; Annexin A5; Antipyrine; Apoptosis; Caspase 12; Cells, Cultured; Cerebral Cortex; Edaravone; Embryo, Mammalian; Endoplasmic Reticulum; Free Radical Scavengers; Glutamic Acid; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Neurons; Rats; Rats, Wistar; Signal Transduction; Statistics, Nonparametric; Time Factors | 2013 |
Edaravone prevents neurotoxicity of mutant L166P DJ-1 in Parkinson's disease.
Topics: Animals; Antipyrine; Apoptosis; Cell Line, Tumor; Edaravone; Free Radical Scavengers; Mice; Mitochondria; Mutation; Oncogene Proteins; Oxidative Stress; Parkinsonian Disorders; Peroxiredoxins; Protein Deglycase DJ-1; Vesicular Monoamine Transport Proteins | 2013 |
Identification of isomeric disaccharides in mixture by the 1-phenyl-3-methyl-5-pyrazolone labeling technique in conjunction with electrospray ionization tandem mass spectrometry.
Topics: Antipyrine; Carbohydrate Conformation; Carbohydrates; Edaravone; Panax; Spectrometry, Mass, Electrospray Ionization | 2013 |
Therapeutic time window for edaravone treatment of traumatic brain injury in mice.
Topics: Animals; Antipyrine; Brain Injuries; Disease Models, Animal; Edaravone; Free Radical Scavengers; Japan; Male; Mice; Mice, Inbred C57BL; Neurons; Oxidative Stress; Reactive Oxygen Species; Tyrosine | 2013 |
Expression of angiotensin II and its receptors in activated microglia in experimentally induced cerebral ischemia in the adult rats.
Topics: Aging; Angiotensin II; Animals; Antipyrine; Blotting, Western; Brain Ischemia; Cerebral Cortex; Edaravone; Gene Expression Regulation; Interleukin-1beta; Male; Microglia; Protein Transport; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Tumor Necrosis Factor-alpha | 2013 |
Combined edaravone and D1-3-n-butylphthalide antioxidant therapy for paraquat poisoning.
Topics: Adult; Antioxidants; Antipyrine; Benzofurans; Drug Therapy, Combination; Edaravone; Emergency Service, Hospital; Humans; Male; Paraquat | 2014 |
Acute kidney injury and edaravone in acute ischemic stroke: the Fukuoka Stroke Registry.
Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Antipyrine; Brain Ischemia; Case-Control Studies; Chi-Square Distribution; Cytoprotection; Edaravone; Female; Free Radical Scavengers; Humans; Japan; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Propensity Score; Registries; Risk Factors; Severity of Illness Index; Stroke | 2013 |
Effects of edaravone, a free radical scavenger, on photochemically induced cerebral infarction in a rat hemiplegic model.
Topics: Animals; Antipyrine; Cerebral Infarction; Edaravone; Free Radical Scavengers; Hemiplegia; Intracranial Thrombosis; Neuroprotective Agents; Photochemistry; Rats; Rats, Wistar; Recovery of Function; Treatment Outcome | 2013 |
[The study of the protective effect and its mechanism of Edaravone to neurons with hydrogen peroxide stimulated].
Topics: 14-3-3 Proteins; Animals; Antipyrine; Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; Cells, Cultured; Edaravone; Free Radical Scavengers; Hydrogen Peroxide; MAP Kinase Signaling System; Mitochondria; Neurons; Neuroprotective Agents; Primary Cell Culture; Rats; Rats, Sprague-Dawley | 2013 |
Local administration of lactic acid and a low dose of the free radical scavenger, edaravone, alleviates myocardial reperfusion injury in rats.
Topics: Animals; Antipyrine; Apoptosis; Dose-Response Relationship, Drug; Edaravone; Free Radical Scavengers; Ischemic Postconditioning; Lactic Acid; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Time Factors | 2013 |
Attenuation of ischemia/reperfusion-induced ovarian damage in rats: does edaravone offer protection?
Topics: Animals; Antipyrine; Caspase 3; Edaravone; Female; Free Radical Scavengers; Glutathione; Immunohistochemistry; Malondialdehyde; Ovary; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2013 |
Neuroprotective effects of edaravone on cognitive deficit, oxidative stress and tau hyperphosphorylation induced by intracerebroventricular streptozotocin in rats.
Topics: Alzheimer Disease; Animals; Antipyrine; Cognition Disorders; Edaravone; Free Radical Scavengers; Infusions, Intraventricular; Male; Nerve Degeneration; Neuroprotective Agents; Oxidative Stress; Phosphorylation; Rats; Streptozocin; tau Proteins | 2013 |
Novel effects of edaravone on human brain microvascular endothelial cells revealed by a proteomic approach.
Topics: Antipyrine; Brain; Cells, Cultured; Edaravone; Endothelial Cells; Endothelium, Vascular; HeLa Cells; Humans; Lactic Acid; Microvessels; Proteomics; Tight Junctions | 2013 |
In vivo optical imaging correlates with improvement of cerebral ischemia treated by intravenous bone marrow stromal cells (BMSCs) and edaravone.
Topics: Animals; Antipyrine; Bone Marrow Cells; Bone Marrow Transplantation; Brain; Brain Ischemia; Disease Models, Animal; Edaravone; Infarction, Middle Cerebral Artery; Male; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Neurosurgical Procedures; Tissue Plasminogen Activator | 2013 |
Oxidative stress interferes with white matter renewal after prolonged cerebral hypoperfusion in mice.
Topics: Animals; Antipyrine; Brain Ischemia; Disease Models, Animal; Edaravone; Free Radical Scavengers; Mice; Nerve Fibers, Myelinated; Neural Stem Cells; Neurogenesis; Oligodendroglia; Oxidative Stress; Reactive Oxygen Species | 2013 |
Edaravone, a free radical scavenger, attenuates cerebral infarction and hemorrhagic infarction in rats with hyperglycemia.
Topics: Animals; Antipyrine; Blood Glucose; Brain; Cerebral Hemorrhage; Cerebral Infarction; Edaravone; Free Radical Scavengers; Hyperglycemia; Infarction, Middle Cerebral Artery; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion | 2014 |
Edaravone protected human brain microvascular endothelial cells from methylglyoxal-induced injury by inhibiting AGEs/RAGE/oxidative stress.
Topics: Antipyrine; Blotting, Western; Brain; Diabetes Complications; Edaravone; Endothelial Cells; Glycation End Products, Advanced; Humans; Microvessels; Oxidative Stress; Pyruvaldehyde; Reactive Oxygen Species; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Rhodamine 123; Tetrazolium Salts; Thiazoles | 2013 |
Analysis of the monosaccharide composition of water-soluble polysaccharides from Sargassum fusiforme by high performance liquid chromatography/electrospray ionisation mass spectrometry.
Topics: Analytic Sample Preparation Methods; Antipyrine; Calibration; China; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Dietary Carbohydrates; Edaravone; Food Analysis; Functional Food; Hydrolysis; Indicators and Reagents; Limit of Detection; Molecular Structure; Monosaccharides; Polysaccharides; Reproducibility of Results; Sargassum; Seaweed; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2014 |
Development and application of a LC-MS/MS assay for the simultaneous quantification of edaravone and taurine in beagle plasma.
Topics: Animals; Antipyrine; Chromatography, High Pressure Liquid; Dogs; Edaravone; Tandem Mass Spectrometry; Taurine | 2013 |
Platelet activating factor induces transient blood-brain barrier opening to facilitate edaravone penetration into the brain.
Topics: Animals; Antipyrine; ATP Binding Cassette Transporter, Subfamily B; Blood-Brain Barrier; Blotting, Western; Brain; Brain Edema; Capillaries; Cerebrospinal Fluid; Cerebrovascular Circulation; Chromatography, High Pressure Liquid; Coloring Agents; E-Selectin; Edaravone; Endothelial Cells; Evans Blue; Flow Cytometry; Infusions, Intravenous; Male; Matrix Metalloproteinase 9; Microdialysis; Neuroprotective Agents; Platelet Activating Factor; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Serum Albumin, Radio-Iodinated; Tetrazolium Salts; Thiazoles | 2014 |
Neuroprotective effects of edaravone after intraventricular hemorrhage in rats.
Topics: Animals; Antipyrine; Brain Edema; Cerebral Hemorrhage; Cognition Disorders; Edaravone; Free Radical Scavengers; Lateral Ventricles; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley | 2014 |
Effect of methylprednisolone and edaravone administration on spinal cord injury.
Topics: Animals; Antipyrine; bcl-X Protein; Caspase 3; Edaravone; Methylprednisolone; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries | 2013 |
Effect of edaravone on acute brainstem-cerebellar infarction with vertigo and sudden hearing loss.
Topics: Aged; Antipyrine; Brain Infarction; Brain Stem Infarctions; Cerebellum; Edaravone; Female; Free Radical Scavengers; Hearing Loss, Sudden; Humans; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Male; Middle Aged; Treatment Outcome; Vertigo | 2014 |
Role of nitric oxide in the onset of facial nerve palsy by HSV-1 infection.
Topics: Animals; Antipyrine; Bell Palsy; Biomarkers; Disease Models, Animal; Edaravone; Facial Nerve; Facial Paralysis; Female; Herpes Simplex; Herpesvirus 1, Human; Mice; Mice, Inbred BALB C; Nitric Oxide; Random Allocation; Reference Values | 2013 |
[Pharmacological postconditioning with lactic acid and low dose edaravone could attenuate myocardial reperfusion injury through mitochondrial pathway].
Topics: Animals; Antipyrine; Apoptosis; Cytochromes c; Disease Models, Animal; Edaravone; Ischemic Postconditioning; Lactic Acid; Male; Mitochondria; Myocardial Reperfusion Injury; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley | 2013 |
Investigation of effect of edaravone on ischemic stroke.
Topics: Adult; Aged; Aged, 80 and over; Antipyrine; Arginine; Edaravone; Female; Free Radical Scavengers; Humans; Ischemia; Male; Methacrylates; Middle Aged; Pipecolic Acids; Retrospective Studies; Risk Factors; Stroke; Sulfonamides; Young Adult | 2013 |
Hydroxypropyl-sulfobutyl-β-cyclodextrin improves the oral bioavailability of edaravone by modulating drug efflux pump of enterocytes.
Topics: Algorithms; Animals; Antipyrine; Area Under Curve; beta-Cyclodextrins; Biological Availability; Caco-2 Cells; Calorimetry, Differential Scanning; Cholesterol; Chromatography, High Pressure Liquid; Edaravone; Enterocytes; Excipients; Humans; Jejunum; L-Lactate Dehydrogenase; Magnetic Resonance Spectroscopy; Membrane Microdomains; Perfusion; Pharmaceutical Preparations; Rats; Rats, Sprague-Dawley; Solubility; X-Ray Diffraction | 2014 |
[Identification of traditional Chinese medicines by oligosaccharide electrophoresis analysis assisted with cluster analysis].
Topics: Antipyrine; Drugs, Chinese Herbal; Edaravone; Electrophoresis, Capillary; Oligosaccharides; Polysaccharides; Reproducibility of Results | 2013 |
Analysis of compositional monosaccharides in fungus polysaccharides by capillary zone electrophoresis.
Topics: Antipyrine; Edaravone; Electrophoresis, Capillary; Fungi; Monosaccharides; Polysaccharides | 2014 |
A multiple free-radical scavenging (MULTIS) study on the antioxidant capacity of a neuroprotective drug, edaravone as compared with uric acid, glutathione, and trolox.
Topics: Antipyrine; Chromans; Edaravone; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Free Radicals; Glutathione; Neuroprotective Agents; Uric Acid | 2014 |
Edaravone protects endotoxin-induced liver injury by inhibiting apoptosis and reducing proinflammatory cytokines.
Topics: Alanine Transaminase; Animals; Antipyrine; Apoptosis; Aspartate Aminotransferases; Caspase 3; Caspase 8; Chemical and Drug Induced Liver Injury; Cytokines; Edaravone; Endotoxins; Enzyme-Linked Immunosorbent Assay; Female; Free Radical Scavengers; Galactosamine; Hepatocytes; In Situ Nick-End Labeling; Interleukin-6; Lipopolysaccharides; Mice, Inbred BALB C; Random Allocation; Tumor Necrosis Factor-alpha | 2014 |
Edaravone rescues the lung by inhibiting lipid peroxidation and pro-inflammatory cytokines in a rat model.
Topics: Acute Lung Injury; Animals; Antipyrine; Cytokines; Edaravone; Free Radical Scavengers; Lipid Peroxidation; Male; Rats; Rats, Sprague-Dawley | 2014 |
Nanofiber-coated drug eluting stent for the stabilization of mast cells.
Topics: Antipyrine; Cell Degranulation; Cell Line; Drug Delivery Systems; Drug-Eluting Stents; Edaravone; Free Radical Scavengers; Humans; Mast Cells; Nanofibers; Nitric Oxide Donors; Reactive Oxygen Species | 2014 |
cRGD mediated liposomes enhanced antidepressant-like effects of edaravone in rats.
Topics: Animals; Antidepressive Agents; Antipyrine; Cell Line, Tumor; Depression; Edaravone; Food Deprivation; Humans; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Liposomes; Male; Motor Activity; Neurons; Prefrontal Cortex; Proto-Oncogene Proteins c-fos; Rats, Sprague-Dawley | 2014 |
[Case of cardiac tamponade during the treatment of acute cerebral infarction].
Topics: Acute Disease; Adenocarcinoma; Anterior Cerebral Artery; Antipyrine; Aspirin; Cardiac Tamponade; Cerebral Infarction; Drainage; Edaravone; Heparin; Humans; Lung Neoplasms; Magnetic Resonance Angiography; Male; Middle Aged; Neoplasm Invasiveness; Pericardium; Treatment Outcome | 2014 |
Effect of edaravone on apoptosis of hippocampus neuron in seizures rats kindled by pentylenetetrazole.
Topics: Animals; Antipyrine; Apoptosis; Caspase 3; Edaravone; fas Receptor; Hippocampus; Kindling, Neurologic; Male; Microtubule-Associated Proteins; Neurons; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Survivin | 2014 |
LC-MS/MS methods for the determination of edaravone and/or taurine in rat plasma and its application to a pharmacokinetic study.
Topics: Administration, Intravenous; Animals; Antipyrine; Chromatography, Liquid; Drug Interactions; Edaravone; Limit of Detection; Linear Models; Male; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tandem Mass Spectrometry; Taurine | 2014 |
Beneficial effects of edaravone on the expression of serum matrix metalloproteinase-9 after cerebral hemorrhage.
Topics: Adult; Aged; Antipyrine; Cerebral Hemorrhage; Edaravone; Female; Free Radical Scavengers; Glasgow Coma Scale; Humans; Male; Matrix Metalloproteinase 9; Middle Aged; Severity of Illness Index; Statistics as Topic | 2014 |
A platform for controlled dual-drug delivery to the retina: protective effects against light-induced retinal damage in rats.
Topics: Administration, Ophthalmic; Animals; Antipyrine; Dinoprost; Drug Combinations; Drug Delivery Systems; Edaravone; Equipment Design; Methacrylates; Neuroprotective Agents; Polyethylene Glycols; Polymethacrylic Acids; Prostheses and Implants; Rats; Retina; Retinal Diseases; Sclera | 2014 |
Altered gene expression in an embolic stroke model after thrombolysis with tissue plasminogen activator and Stachybotrys microspora triprenyl phenol-7.
Topics: Animals; Antioxidants; Antipyrine; Benzopyrans; Calgranulin A; Disease Models, Animal; Edaravone; Free Radical Scavengers; Gene Expression; Inflammation; Interleukin-6; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred Strains; Pyrrolidinones; Reactive Oxygen Species; STAT3 Transcription Factor; Stroke; Thrombolytic Therapy; Tissue Plasminogen Activator | 2014 |
Protective role of edaravone against neomycin-induced ototoxicity in zebrafish.
Topics: Animals; Animals, Genetically Modified; Antipyrine; Apoptosis; Cells, Cultured; Dose-Response Relationship, Drug; Edaravone; Embryo, Nonmammalian; Hair Cells, Auditory; In Situ Nick-End Labeling; Microscopy, Confocal; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Mitochondria; Neomycin; Neuroprotective Agents; Zebrafish | 2014 |
Inhibitory effects of edaravone in β-amyloid-induced neurotoxicity in rats.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antipyrine; CA1 Region, Hippocampal; Disease Models, Animal; Edaravone; Free Radical Scavengers; Learning; Male; Memory; Neurotoxicity Syndromes; Peptide Fragments; Rats; Rats, Sprague-Dawley | 2014 |
Edaravone mitigates hexavalent chromium-induced oxidative stress and depletion of antioxidant enzymes while estrogen restores antioxidant enzymes in the rat ovary in F1 offspring.
Topics: Animals; Animals, Suckling; Antipyrine; Apoptosis; Dose-Response Relationship, Drug; Edaravone; Estradiol; Estrogens; Female; Free Radical Scavengers; Gene Expression Regulation, Enzymologic; Heavy Metal Poisoning; Infertility, Female; Injections, Intraperitoneal; Lactation; Maternal-Fetal Exchange; Ovary; Oxidative Stress; Oxidoreductases; Poisoning; Potassium Dichromate; Pregnancy; Rats, Sprague-Dawley; Water Pollutants, Chemical | 2014 |
Edaravone, a free radical scavenger, improves the graft viability on liver transplantation from non-heart-beating donors in pigs.
Topics: Adenosine; Allopurinol; Animals; Antipyrine; Biomarkers; Cold Ischemia; Cytoprotection; Edaravone; Free Radical Scavengers; Glutathione; Graft Survival; Insulin; Liver; Liver Transplantation; Male; Models, Animal; Organ Preservation Solutions; Raffinose; Reperfusion Injury; Swine; Time Factors; Tissue and Organ Harvesting; Tissue Survival; Warm Ischemia | 2014 |
A radical scavenger edaravone inhibits matrix metalloproteinase-9 upregulation and blood-brain barrier breakdown in a mouse model of prolonged cerebral hypoperfusion.
Topics: Animals; Antipyrine; Blood-Brain Barrier; Carotid Artery, Common; Carotid Stenosis; Cell Death; Cell Survival; Cerebral Cortex; Cerebrovascular Circulation; Edaravone; Free Radical Scavengers; Hypoxia, Brain; Male; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice, Inbred C57BL; Oligodendroglia; Up-Regulation; White Matter | 2014 |
Edaravone inhibits hypoxia-induced trophoblast-soluble Fms-like tyrosine kinase 1 expression: a possible therapeutic approach to preeclampsia.
Topics: Antipyrine; Cell Hypoxia; Cell Line; Cobalt; Edaravone; Female; Free Radical Scavengers; Gene Expression; Human Umbilical Vein Endothelial Cells; Humans; Placenta Growth Factor; Pre-Eclampsia; Pregnancy; Pregnancy Proteins; Reactive Oxygen Species; RNA, Messenger; Trophoblasts; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1 | 2014 |
Suppression of oxidative stress and 5-lipoxygenase activation by edaravone improves depressive-like behavior after concussion.
Topics: Animals; Antipyrine; Arachidonate 5-Lipoxygenase; Brain; Brain Chemistry; Brain Concussion; Depressive Disorder; Dose-Response Relationship, Drug; Edaravone; Enzyme Activation; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Oxidative Stress; Psychomotor Performance; Swimming | 2014 |
3-Methyl-1-phenyl-2-pyrazolin-5-one or N-acetylcysteine prevents hippocampal mossy fiber sprouting and rectifies subsequent convulsive susceptibility in a rat model of kainic acid-induced seizure ceased by pentobarbital.
Topics: Acetylcysteine; Aldehydes; Animals; Anticonvulsants; Antipyrine; Cell Survival; Edaravone; Excitatory Amino Acid Antagonists; Free Radical Scavengers; Glutathione; Kainic Acid; Male; Mossy Fibers, Hippocampal; Pentobarbital; Rats; Rats, Sprague-Dawley; Seizures | 2014 |
Edaravone protect against retinal damage in streptozotocin-induced diabetic mice.
Topics: Animals; Antipyrine; Blotting, Western; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Edaravone; Electroretinography; Free Radical Scavengers; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Reactive Oxygen Species; Retinal Diseases; Retinal Ganglion Cells | 2014 |
Synergy of combined tPA-edaravone therapy in experimental thrombotic stroke.
Topics: Animals; Antipyrine; Cell Hypoxia; Disease Models, Animal; Drug Synergism; Edaravone; Humans; Hypoxia-Ischemia, Brain; Intracranial Thrombosis; Male; Mice; Mice, Inbred C57BL; Stroke; Tissue Plasminogen Activator; White Matter | 2014 |
Nonreductive chemical release of intact N-glycans for subsequent labeling and analysis by mass spectrometry.
Topics: Amino Acid Sequence; Analytic Sample Preparation Methods; Animals; Antipyrine; Cattle; Cost-Benefit Analysis; Edaravone; Fucose; Glycomics; Glycoproteins; Hydrogen-Ion Concentration; Oxidation-Reduction; Plant Proteins; Polysaccharides; Spectrometry, Mass, Electrospray Ionization; Staining and Labeling; Tandem Mass Spectrometry | 2014 |
Edaravone protected PC12 cells against MPP(+)-cytoxicity via inhibiting oxidative stress and up-regulating heme oxygenase-1 expression.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Animals; Antipyrine; Dose-Response Relationship, Drug; Drug Interactions; Edaravone; Enzyme Inhibitors; Flow Cytometry; Free Radical Scavengers; Heme Oxygenase (Decyclizing); Neurotoxins; Oxidative Stress; PC12 Cells; Protoporphyrins; Rats; Up-Regulation | 2014 |
Pericyte protection by edaravone after tissue plasminogen activator treatment in rat cerebral ischemia.
Topics: Acetylglucosamine; Animals; Antipyrine; Astrocytes; Brain Ischemia; Cell Proliferation; Disease Models, Animal; Edaravone; Free Radical Scavengers; Glial Cell Line-Derived Neurotrophic Factor; Glial Fibrillary Acidic Protein; Male; Pericytes; Quinolines; Rats; Rats, Wistar; Receptor, Platelet-Derived Growth Factor beta; Reperfusion; Time Factors; Tissue Plasminogen Activator | 2014 |
Edaravone protects neurons in the rat substantia nigra against 6-hydroxydopamine-induced oxidative stress damage.
Topics: Animals; Antipyrine; Behavior, Animal; Corpus Striatum; Edaravone; Glutathione; Male; Malondialdehyde; Neurons; Neuroprotective Agents; Oxidative Stress; Oxidopamine; Rats; Rats, Sprague-Dawley; Substantia Nigra | 2014 |
Teriravone induces neurotoxicity in beagle dogs.
Topics: Animals; Antipyrine; Calcium-Binding Proteins; Cell Adhesion Molecules, Neuronal; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Edaravone; Female; Free Radical Scavengers; Gene Expression Profiling; Interleukin-2; Laminin; Male; Mesencephalon; Nerve Tissue Proteins; Neural Cell Adhesion Molecules; Neurotoxicity Syndromes; Oligonucleotide Array Sequence Analysis; Up-Regulation | 2014 |
The synergetic effect of edaravone and borneol in the rat model of ischemic stroke.
Topics: Animals; Anti-Inflammatory Agents; Antipyrine; Brain; Brain Ischemia; Camphanes; Cell Survival; Cells, Cultured; Coculture Techniques; Cyclooxygenase 2; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Edaravone; Free Radical Scavengers; Interleukin-1beta; Maze Learning; Neuroglia; Neurons; Rats, Sprague-Dawley; Stroke; Tumor Necrosis Factor-alpha | 2014 |
Edaravone protects against methylglyoxal-induced barrier damage in human brain endothelial cells.
Topics: Antipyrine; beta Catenin; Blood-Brain Barrier; Cell Line; Cell Survival; Claudin-5; Edaravone; Electric Impedance; Endothelial Cells; Endothelium, Vascular; Free Radical Scavengers; Guanidines; Humans; Oxidative Stress; Permeability; Protective Agents; Pyruvaldehyde; Reactive Oxygen Species; Tight Junctions | 2014 |
Effects of edaravone on early outcomes in acute ischemic stroke patients treated with recombinant tissue plasminogen activator.
Topics: Aged; Aged, 80 and over; Antipyrine; Databases, Factual; Edaravone; Female; Fibrinolytic Agents; Free Radical Scavengers; Humans; Japan; Male; Retrospective Studies; Stroke; Tissue Plasminogen Activator; Treatment Outcome | 2014 |
[A case of cerebral fat embolism after artificial bone replacement operation for femoral head fracture].
Topics: Aged, 80 and over; Antipyrine; Arthroplasty, Replacement, Hip; Diffusion Magnetic Resonance Imaging; Edaravone; Embolism, Fat; Female; Femoral Neck Fractures; Humans; Intracranial Embolism; Postoperative Complications; Prognosis; Syndrome | 2014 |
Edaravone protects human peripheral blood lymphocytes from γ-irradiation-induced apoptosis and DNA damage.
Topics: Adult; Antipyrine; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cells, Cultured; Comet Assay; DNA Damage; Edaravone; Free Radical Scavengers; Gamma Rays; Humans; Lymphocytes; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species | 2015 |
Effects of edaravone, a radical scavenger, on hepatocyte transplantation.
Topics: Animals; Antipyrine; Apoptosis; Edaravone; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Hepatocytes; In Situ Nick-End Labeling; Liver Failure, Acute; Liver Transplantation; Male; Rats; Rats, Inbred Lew; Rats, Inbred Strains; Serum Albumin; Spleen | 2014 |
Chemical repair activity of free radical scavenger edaravone: reduction reactions with dGMP hydroxyl radical adducts and suppression of base lesions and AP sites on irradiated plasmid DNA.
Topics: Antipyrine; Base Sequence; DNA Adducts; DNA Damage; DNA Repair; Dose-Response Relationship, Radiation; Edaravone; Free Radical Scavengers; Hydroxyl Radical; Molecular Sequence Data; Oxidation-Reduction; Plasmids; Pulse Radiolysis; Radiation Dosage | 2015 |
Multiple left ventricular thrombi in a patient with dilated cardiomyopathy and cerebral infarction: a case report.
Topics: Aged; Anticoagulants; Antipyrine; Cardiomyopathy, Dilated; Cerebral Infarction; Edaravone; Heart Diseases; Heparin; Humans; Male; Thrombosis | 2014 |
Two complementary liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods to study the excretion and metabolic interaction of edaravone and taurine in rats.
Topics: Animals; Antipyrine; Bile; Chromatography, Liquid; Drug Stability; Edaravone; Feces; Linear Models; Male; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Taurine | 2014 |
The neuroprotective properties of the superoxide dismutase mimetic tempol correlate with its ability to reduce pathological glutamate release in a rodent model of stroke.
Topics: Alanine; Animals; Antipyrine; Astrocytes; Brain; Cells, Cultured; Cyclic N-Oxides; Drug Evaluation, Preclinical; Edaravone; Free Radical Scavengers; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Molecular Mimicry; Neuroprotective Agents; Oxidative Stress; Rats, Sprague-Dawley; Spin Labels; Superoxides; Synaptosomes; Taurine | 2014 |
Fingerprint analysis of polysaccharides from different Ganoderma by HPLC combined with chemometrics methods.
Topics: Antipyrine; Chromatography, High Pressure Liquid; Edaravone; Ganoderma; Monosaccharides; Polysaccharides | 2014 |
Changes in cerebrospinal fluid biomarkers in human herpesvirus-6-associated acute encephalopathy/febrile seizures.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adolescent; Antipyrine; Biomarkers; Child; Deoxyguanosine; DNA Damage; Edaravone; Female; Herpesvirus 6, Human; Humans; Male; Roseolovirus Infections; Seizures, Febrile; Young Adult | 2014 |
Edaravone ameliorates the adverse effects of valproic acid toxicity in small intestine.
Topics: Alkaline Phosphatase; Animals; Antipyrine; Edaravone; Female; Free Radical Scavengers; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Intestine, Small; Malondialdehyde; N-Acetylneuraminic Acid; Peroxidase; Rats, Sprague-Dawley; Superoxide Dismutase; Thromboplastin; Valproic Acid | 2015 |
[Lateral medullary infarction presenting with truncal lateropulsion and decreased pain and temperature sensation below T10 sensory level].
Topics: Antipyrine; Arginine; Cerebral Infarction; Clopidogrel; Drug Therapy, Combination; Edaravone; Free Radical Scavengers; Humans; Lateral Medullary Syndrome; Magnetic Resonance Imaging; Male; Medulla Oblongata; Middle Aged; Pipecolic Acids; Platelet Aggregation Inhibitors; Somatosensory Disorders; Sulfonamides; Ticlopidine; Treatment Outcome; Vertebral Artery Dissection | 2014 |
Edaravone attenuates brain damage in rats after acute CO poisoning through inhibiting apoptosis and oxidative stress.
Topics: Acute Disease; Animals; Antipyrine; Apoptosis; Brain; Brain Diseases; Carbon Monoxide Poisoning; Edaravone; Heme Oxygenase-1; Hippocampus; Male; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Rats; Rats, Sprague-Dawley | 2016 |
Pre- and posttreatment with edaravone protects CA1 hippocampus and enhances neurogenesis in the subgranular zone of dentate gyrus after transient global cerebral ischemia in rats.
Topics: Animals; Animals, Newborn; Antipyrine; Apoptosis; CA1 Region, Hippocampal; Cell Death; Cells, Cultured; Dentate Gyrus; Disease Models, Animal; Doublecortin Domain Proteins; Edaravone; Free Radical Scavengers; Glial Fibrillary Acidic Protein; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Ischemic Attack, Transient; Male; Microtubule-Associated Proteins; Neural Stem Cells; Neurogenesis; Neuropeptides; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2014 |
Anti-inflammatory effects of Edaravone and Scutellarin in activated microglia in experimentally induced ischemia injury in rats and in BV-2 microglia.
Topics: Animals; Anti-Inflammatory Agents; Antipyrine; Apigenin; Brain; Brain Ischemia; Cell Count; Cell Line; Cell Survival; Cytokines; Disease Models, Animal; Edaravone; Glucuronates; Infarction, Middle Cerebral Artery; Lipopolysaccharides; Male; Microglia; Nitric Oxide; Nitric Oxide Synthase Type II; Random Allocation; Rats, Sprague-Dawley; Reactive Oxygen Species | 2014 |
The radical scavenger edaravone improves neurologic function and perihematomal glucose metabolism after acute intracerebral hemorrhage.
Topics: Animals; Antipyrine; Behavior, Animal; Body Water; Brain Edema; Cell Death; Edaravone; Fluorodeoxyglucose F18; Free Radical Scavengers; Glucose; Intracranial Hemorrhages; Male; Nervous System Diseases; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Stroke | 2015 |
Edaravone prevents lung injury induced by hepatic ischemia-reperfusion.
Topics: Acute Lung Injury; Alanine Transaminase; Animals; Antipyrine; Aspartate Aminotransferases; Cytokines; Drug Evaluation, Preclinical; Edaravone; Free Radical Scavengers; Liver; Lung; Male; Malondialdehyde; Random Allocation; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury | 2015 |
Structural investigation of a uronic acid-containing polysaccharide from abalone by graded acid hydrolysis followed by PMP-HPLC-MSn and NMR analysis.
Topics: Antipyrine; Carbohydrate Sequence; Chromatography, High Pressure Liquid; Edaravone; Hydrolysis; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Sequence Data; Polysaccharides; Uronic Acids | 2015 |
[Case of spontaneous cervical internal carotid artery dissection with embolic stroke after a job-change].
Topics: Antipyrine; Arginine; Carotid Artery, Internal, Dissection; Diagnosis, Differential; Edaravone; Humans; Infarction, Middle Cerebral Artery; Intracranial Embolism; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Male; Middle Aged; Personnel Turnover; Pipecolic Acids; Platelet Aggregation Inhibitors; Stress, Psychological; Stroke; Sulfonamides; Workload; Workplace | 2014 |
Study on the interaction of plasma protein binding rate between edaravone and taurine in human plasma based on HPLC analysis coupled with ultrafiltration technique.
Topics: Antipyrine; Blood Proteins; Chromatography, High Pressure Liquid; Edaravone; Free Radical Scavengers; Humans; Limit of Detection; Protein Binding; Taurine; Ultrafiltration | 2015 |
Solid lipid nanoparticles loaded with edaravone for inner ear protection after noise exposure.
Topics: Animals; Antipyrine; Ear, Inner; Edaravone; Female; Guinea Pigs; Hearing Loss, Noise-Induced; Lipids; Nanoparticles; Reactive Oxygen Species | 2015 |
Compound IMM-H004, a novel coumarin derivative, protects against CA1 cell loss and spatial learning impairments resulting from transient global ischemia.
Topics: Animals; Antipyrine; bcl-2-Associated X Protein; Brain Ischemia; CA1 Region, Hippocampal; Caspase 3; Cell Death; Coumarins; Disease Models, Animal; Disks Large Homolog 4 Protein; Drug Evaluation, Preclinical; Edaravone; Free Radical Scavengers; Intracellular Signaling Peptides and Proteins; Learning Disabilities; Male; Maze Learning; Membrane Proteins; Neurons; Neuroprotective Agents; Nootropic Agents; Random Allocation; Rats, Sprague-Dawley; Spatial Memory; Synapsins | 2015 |
[Dystypia after ischemic stroke: a disturbance of linguistic processing for Romaji (Romanized Japanese)?].
Topics: Aged; Agraphia; Anticoagulants; Antipyrine; Aphasia; Diffusion Magnetic Resonance Imaging; Drug Therapy, Combination; Edaravone; Female; Free Radical Scavengers; Heparin; Humans; Japan; Language; Stroke; Stroke Rehabilitation; Warfarin; Word Processing | 2015 |
[Full Recovery from Cardiopulmonary Arrest caused by Traumatic Asphyxia].
Topics: Accidents, Occupational; Antipyrine; Asphyxia; Cardiopulmonary Resuscitation; Edaravone; Heart Arrest; Heart Massage; Humans; Hypothermia, Induced; Male; Middle Aged; Respiration, Artificial; Thoracic Injuries; Treatment Outcome | 2015 |
Protective effects of edaravone combined puerarin on inhalation lung injury induced by black gunpowder smog.
Topics: Animals; Antipyrine; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Drug Therapy, Combination; Edaravone; Inhalation Exposure; Isoflavones; Lung; Lung Injury; Male; Organ Size; Rats, Wistar; Smog | 2015 |
Ultra-HPLC method for quality and adulterant assessment of steviol glycosides sweeteners - Stevia rebaudiana and stevia products.
Topics: Antipyrine; Chromatography, High Pressure Liquid; Diterpenes, Kaurane; Edaravone; Food Analysis; Food Contamination; Glucose; Glucosides; Glycosides; Limit of Detection; Non-Nutritive Sweeteners; Reproducibility of Results; Sensitivity and Specificity; Stevia | 2015 |
A nitric oxide-donor furoxan moiety improves the efficacy of edaravone against early renal dysfunction and injury evoked by ischemia/reperfusion.
Topics: Acetylglucosamine; Acute-Phase Proteins; Animals; Antipyrine; Creatinine; Disease Models, Animal; Edaravone; Free Radical Scavengers; Ischemia; Kidney; Lipid Peroxidation; Lipocalin-2; Lipocalins; Male; Malondialdehyde; Nitric Oxide Donors; Oxadiazoles; Oxidative Stress; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Reperfusion Injury; Urea | 2015 |
Evaluation of edaravone against radiation-induced oral mucositis in mice.
Topics: Animals; Antioxidants; Antipyrine; Edaravone; Mice, Inbred ICR; Peroxidase; Radiation Dosage; Radiation Injuries, Experimental; Reactive Oxygen Species; Stomatitis; Thiobarbiturates | 2015 |
Edaravone alleviates Alzheimer's disease-type pathologies and cognitive deficits.
Topics: Administration, Oral; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Antipyrine; Behavior, Animal; Brain; Cell Line; Cognition Disorders; Dendrites; Edaravone; Humans; Inflammation; Mice, Transgenic; Neurotoxins; Oxidative Stress; Phosphorylation; Presenilin-1; Protein Aggregation, Pathological; Protein Processing, Post-Translational; tau Proteins | 2015 |
Evaluation of sample preparation and chromatographic separation for the parallel determination of taurine and edaravone in rat tissues using HILIC-MS/MS.
Topics: Animals; Antipyrine; Brain Chemistry; Chromatography, Liquid; Edaravone; Kidney; Liver; Myocardium; Rats; Spleen; Tandem Mass Spectrometry; Taurine | 2015 |
Effects of edaravone on cardiac damage in valproic acid induced toxicity.
Topics: Alkaline Phosphatase; Animals; Antipyrine; Catalase; Edaravone; Female; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Lipid Peroxidation; Malondialdehyde; Myocardium; N-Acetylneuraminic Acid; Peroxidase; Rats; Sodium-Potassium-Exchanging ATPase; Superoxide Dismutase; Thromboplastin; Valproic Acid | 2015 |
Edaravone protects rats against oxidative stress and apoptosis in experimentally induced myocardial infarction: Biochemical and ultrastructural evidence.
Topics: Animals; Antioxidants; Antipyrine; Apoptosis; C-Reactive Protein; Caspase 3; Creatine Kinase, MB Form; Disease Models, Animal; Dose-Response Relationship, Drug; Edaravone; Free Radical Scavengers; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Heart; Inflammation; Isoproterenol; L-Lactate Dehydrogenase; Myocardial Infarction; Myocardium; Oxidative Stress; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances | 2015 |
The free-radical scavenger edaravone accelerates thrombolysis with alteplase in an experimental thrombosis model.
Topics: Animals; Antipyrine; Disease Models, Animal; Edaravone; Fibrinolysis; Fibrinolytic Agents; Free Radical Scavengers; Male; Microcirculation; Placebos; Rats; Rats, Wistar; Reperfusion Injury; Stroke; Thrombolytic Therapy; Thrombosis; Time Factors; Tissue Plasminogen Activator | 2015 |
[The effect of edaravone on MAPKs signal pathway associated with Abeta(25-35) treatment in PC12 cells].
Topics: Amyloid beta-Peptides; Animals; Anthracenes; Antipyrine; Edaravone; Imidazoles; MAP Kinase Signaling System; PC12 Cells; Peptide Fragments; Pyridines; Rats | 2015 |
Prophylactic Edaravone Prevents Transient Hypoxic-Ischemic Brain Injury: Implications for Perioperative Neuroprotection.
Topics: Animals; Antipyrine; Edaravone; Free Radical Scavengers; Hypoxia-Ischemia, Brain; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Perioperative Care; Random Allocation | 2015 |
The edaravone and 3-n-butylphthalide ring-opening derivative 10b effectively attenuates cerebral ischemia injury in rats.
Topics: Animals; Antioxidants; Antipyrine; Apoptosis; Benzofurans; Brain; Edaravone; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; NF-kappa B; Rats, Sprague-Dawley; Signal Transduction; Water | 2015 |
Determination of the degree of acetylation and the distribution of acetyl groups in chitosan by HPLC analysis of nitrous acid degraded and PMP labeled products.
Topics: Acetylation; Antipyrine; Chitosan; Chromatography, High Pressure Liquid; Edaravone; Glucosamine; Mannose; Nitrous Acid; Oligosaccharides; Staining and Labeling | 2015 |
Effect of N-n-butyl haloperidol iodide on ROS/JNK/Egr-1 signaling in H9c2 cells after hypoxia/reoxygenation.
Topics: Acetylcysteine; Antipyrine; Cell Hypoxia; Cell Line; Early Growth Response Protein 1; Edaravone; Gene Expression Regulation; Haloperidol; Humans; MAP Kinase Kinase 4; MAP Kinase Signaling System; Myocardial Reperfusion Injury; Myocytes, Cardiac; Oxidative Stress; Reactive Oxygen Species; Xanthine Oxidase | 2015 |
Edaravone protects rats and human pulmonary alveolar epithelial cells against hyperoxia injury: heme oxygenase-1 and PI3K/Akt pathway may be involved.
Topics: Acute Lung Injury; Alveolar Epithelial Cells; Animals; Antioxidants; Antipyrine; Cell Survival; Cells, Cultured; Edaravone; Epithelial Cells; Heme Oxygenase-1; Humans; Hyperoxia; Male; Oxidation-Reduction; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Protoporphyrins; Rats; Rats, Sprague-Dawley; Up-Regulation | 2015 |
Edaravone injection ameliorates cognitive deficits in rat model of Alzheimer's disease.
Topics: Acetylcholinesterase; Aldehydes; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antipyrine; Choline O-Acetyltransferase; Dentate Gyrus; Disease Models, Animal; Edaravone; Immunohistochemistry; Maze Learning; Neuroprotective Agents; Nootropic Agents; Oxidative Stress; Peptide Fragments; Random Allocation; Rats, Wistar; Spatial Memory | 2015 |
[Protective effect of novel edaravone and danshensu conjugate on focal cerebral ischemia-reperfusion injury
in rats and its underlying mechanism].
Topics: Animals; Antipyrine; Brain Edema; Brain Ischemia; Cerebral Infarction; Edaravone; Lactates; Malondialdehyde; Rats; Reperfusion Injury; Superoxide Dismutase | 2015 |
Discovery of 3-n-butyl-2,3-dihydro-1H-isoindol-1-one as a potential anti-ischemic stroke agent.
Topics: Animals; Antioxidants; Antipyrine; Behavior, Animal; Benzofurans; Biological Availability; Brain; Carrageenan; Cell Line; Disease Models, Animal; Edaravone; Fibrinolytic Agents; Infarction, Middle Cerebral Artery; Isoindoles; Male; Mice; Molecular Structure; Neuroprotective Agents; Oxidative Stress; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats, Sprague-Dawley; Reperfusion Injury; Structure-Activity Relationship; Thrombosis; Tissue Distribution | 2015 |
Edaravone protects osteoblastic cells from dexamethasone through inhibiting oxidative stress and mPTP opening.
Topics: 3T3 Cells; Animals; Antipyrine; Apoptosis; Caspase 3; Cell Line, Tumor; Cyclophilins; Cyclosporine; Dexamethasone; Edaravone; Humans; Membrane Potential, Mitochondrial; Mice; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Osteoblasts; Osteonecrosis; Oxidative Stress; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering | 2015 |
Quantitative fingerprinting of O-linked glycans released from proteins using isotopic coded labeling with deuterated 1-phenyl-3-methyl-5-pyrazolone.
Topics: Antipyrine; Chromatography, High Pressure Liquid; Deuterium; Edaravone; Glycoproteins; Isotope Labeling; Mucins; Polysaccharides; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization | 2015 |
Novel hybrids of 3-n-butylphthalide and edaravone: Design, synthesis and evaluations as potential anti-ischemic stroke agents.
Topics: Animals; Antipyrine; Benzofurans; Cell Line; Drug Design; Edaravone; Free Radical Scavengers; Humans; Hydrogen Peroxide; Neurons; Neuroprotective Agents; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Stroke | 2015 |
Edaravone, a potent free radical scavenger, reacts with peroxynitrite to produce predominantly 4-NO-edaravone.
Topics: Antipyrine; Edaravone; Free Radical Scavengers; Lipid Peroxidation; Neuroprotective Agents; Oxidation-Reduction; Peroxynitrous Acid; Uric Acid | 2016 |
Efficacy, safety, and outcomes in 17 pediatric cases treated with the free radical scavenger edaravone.
Topics: Adolescent; Antipyrine; Brain Ischemia; Child; Child, Preschool; Edaravone; Female; Free Radical Scavengers; Humans; Infant; Infant, Newborn; Male; Moyamoya Disease; Treatment Outcome | 2015 |
Edaravone leads to proteome changes indicative of neuronal cell protection in response to oxidative stress.
Topics: Antipyrine; Apoptosis; Cell Line; Cell Survival; Edaravone; Free Radical Scavengers; Humans; Neurons; Neuroprotective Agents; Oxidative Stress; Proteome; Reactive Oxygen Species | 2015 |
Reactive oxygen species mediate axis-cotyledon signaling to induce reserve mobilization during germination and seedling establishment in Vigna radiata.
Topics: Antioxidants; Antipyrine; Cell Division; Cotyledon; Edaravone; Fabaceae; Free Radical Scavengers; Germination; Hydroxyurea; Plant Shoots; Reactive Oxygen Species; Seedlings; Signal Transduction | 2015 |
Protective role of edaravone against cisplatin-induced ototoxicity in an auditory cell line.
Topics: Animals; Antineoplastic Agents; Antioxidants; Antipyrine; Apoptosis; Caspase 3; Cell Line; Cell Survival; Cisplatin; Edaravone; Free Radical Scavengers; Hair Cells, Auditory; Hearing; Hearing Loss; Immunoblotting; Mice; Microscopy, Fluorescence; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species | 2015 |
Comparison of polysaccharides of Haliotis discus hannai and Volutharpa ampullacea perryi by PMP-HPLC-MS(n) analysis upon acid hydrolysis.
Topics: Acids; Animals; Antipyrine; Chromatography, High Pressure Liquid; Edaravone; Gonads; Hydrolysis; Monosaccharides; Polysaccharides; Snails; Uronic Acids; Viscera | 2015 |
Sensitive determination of glucose in Dulbecco's modified Eagle medium by high-performance liquid chromatography with 1-phenyl-3-methyl-5-pyrazolone derivatization: application to gluconeogenesis studies.
Topics: Antipyrine; Chromatography, High Pressure Liquid; Culture Media; Edaravone; Gluconeogenesis; Glucose; Hep G2 Cells; Humans; Limit of Detection; Liquid-Liquid Extraction | 2016 |
Protective effects of edaravone, a free radical scavenger, on lipopolysaccharide-induced acute kidney injury in a rat model of sepsis.
Topics: Acute Kidney Injury; Animals; Antipyrine; Apoptosis; Blood Urea Nitrogen; Catalase; Cells, Cultured; Disease Models, Animal; Edaravone; Free Radical Scavengers; Glutathione; Interleukin-6; Kidney Tubules; Lipopolysaccharides; Male; Malondialdehyde; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Dynamics; Oxidative Stress; Rats; Rats, Wistar; Sepsis; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2015 |
Protective effect of edaravone against manganese-induced toxicity in cultured rat astrocytes.
Topics: Animals; Antioxidants; Antipyrine; Apoptosis; Astrocytes; Cell Survival; Cells, Cultured; Cerebral Cortex; Edaravone; Lipid Peroxidation; Manganese; Oxidative Stress; Rats; Rats, Sprague-Dawley | 2015 |
The Therapeutic Effect of Stellate Ganglion Block on Facial Nerve Palsy in Patients with Type 2 Diabetes Mellitus.
Topics: Adult; Anesthetics, Local; Antipyrine; Aspirin; Autonomic Nerve Block; Blood Glucose; Dexamethasone; Diabetes Mellitus, Type 2; Edaravone; Facial Nerve Diseases; Facial Paralysis; Female; Free Radical Scavengers; Glucocorticoids; Humans; Lidocaine; Male; Middle Aged; Phosphodiesterase Inhibitors; Platelet Aggregation Inhibitors; Prednisone; Retrospective Studies; Stellate Ganglion; Thiamine; Treatment Outcome; Vinca Alkaloids; Vitamin B 12; Vitamin B Complex | 2015 |
Edaravone attenuates monocyte adhesion to endothelial cells induced by oxidized low-density lipoprotein.
Topics: Antipyrine; Atherosclerosis; Cell Adhesion; Cell Line; Edaravone; Endothelial Cells; Free Radical Scavengers; Human Umbilical Vein Endothelial Cells; Humans; Lipoproteins, LDL; Monocytes | 2015 |
Effect of free radical scavenger, edaravone, for patients with carbon monoxide poisoning.
Topics: Activities of Daily Living; Adult; Antipyrine; Carbon Monoxide Poisoning; Case-Control Studies; Cognition; Combined Modality Therapy; Edaravone; Female; Free Radical Scavengers; Humans; Hyperbaric Oxygenation; Male; Middle Aged; Retrospective Studies; Treatment Outcome | 2015 |
Edaravone, a Free Radical Scavenger, Delayed Symptomatic and Pathological Progression of Motor Neuron Disease in the Wobbler Mouse.
Topics: Amyotrophic Lateral Sclerosis; Animals; Antipyrine; Astrocytes; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Drug Administration Schedule; Edaravone; Free Radical Scavengers; Injections, Intraperitoneal; Mice; Muscle Contraction; Muscle Strength; Random Allocation | 2015 |
Inhibitory Effects of Edaravone, a Free Radical Scavenger, on Cytokine-induced Hyperpermeability of Human Pulmonary Microvascular Endothelial Cells:A Comparison with Dexamethasone and Nitric Oxide Synthase Inhibitor.
Topics: Antigens, CD; Antipyrine; Cadherins; Capillary Permeability; Cells, Cultured; Cytokines; Dexamethasone; Edaravone; Endothelial Cells; Free Radical Scavengers; Humans; Intercellular Adhesion Molecule-1; Nitric Oxide Synthase; omega-N-Methylarginine; Zonula Occludens-1 Protein | 2015 |
Edaravone abrogates LPS-induced behavioral anomalies, neuroinflammation and PARP-1.
Topics: Adaptation, Ocular; Animals; Antipyrine; Anxiety; Catalase; Disease Models, Animal; Dose-Response Relationship, Drug; Edaravone; Encephalitis; Exploratory Behavior; Free Radical Scavengers; Glutathione; Hindlimb Suspension; Lipopolysaccharides; Male; Maze Learning; Mental Disorders; Mice; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Superoxide Dismutase; Swimming | 2016 |
Metabolomic Analyses of Brain Tissue in Sepsis Induced by Cecal Ligation Reveal Specific Redox Alterations--Protective Effects of the Oxygen Radical Scavenger Edaravone.
Topics: Animals; Antipyrine; Apoptosis; bcl-2-Associated X Protein; Brain; Cecum; Cell Death; Edaravone; Free Radical Scavengers; Ligation; Metabolomics; Mice; Microscopy, Electron; Neurons; Oxidation-Reduction; Oxygen; Phenotype; Polymerase Chain Reaction; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Sepsis | 2015 |
Protective Effect of Edaravone in Primary Cerebellar Granule Neurons against Iodoacetic Acid-Induced Cell Injury.
Topics: Animals; Antipyrine; Apoptosis; Caspase 3; Cell Survival; Cells, Cultured; Edaravone; Iodoacetic Acid; Membrane Potential, Mitochondrial; Microscopy, Fluorescence; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley | 2015 |
Protective effect of Edaravone against hypoxia-induced cytotoxicity in osteoblasts MC3T3-E1 cells.
Topics: Animals; Antipyrine; Apoptosis; Caspase 3; Cell Hypoxia; Cell Survival; Cells, Cultured; Cytochromes c; Edaravone; Mice; Nitric Oxide; Osteoblasts; Oxidative Stress; Protective Agents; Reactive Oxygen Species | 2015 |
Diversification of edaravone via palladium-catalyzed hydrazine cross-coupling: Applications against protein misfolding and oligomerization of beta-amyloid.
Topics: Amyloid beta-Peptides; Antipyrine; Catalysis; Dose-Response Relationship, Drug; Edaravone; Hydrazines; Molecular Structure; Organometallic Compounds; Palladium; Protein Folding; Protein Multimerization; Structure-Activity Relationship | 2016 |
[Effect of edaravone on oxidative stress and myocardial fibrosis induced by isoproterenol in rats].
Topics: Animals; Antipyrine; Cardiomyopathies; Collagen; Disease Models, Animal; Drugs, Chinese Herbal; Edaravone; Heart; Hydroxyproline; Isoproterenol; Male; Malondialdehyde; Myocardium; Oxidative Stress; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Transforming Growth Factor beta1 | 2015 |
Protection by Edaravone, a Radical Scavenger, against Manganese-Induced Neurotoxicity in Rats.
Topics: Animals; Antipyrine; Brain; Chlorides; Edaravone; Electron Transport Complex I; Free Radical Scavengers; Lipid Peroxidation; Magnetic Resonance Imaging; Male; Manganese Compounds; Manganese Poisoning; Mitochondria; Motor Activity; Neuroprotective Agents; Oxidative Stress; Protein Carbonylation; Rats; Rats, Sprague-Dawley; Weight Gain | 2016 |
Combination of edaravone and neural stem cell transplantation repairs injured spinal cord in rats.
Topics: Animals; Antipyrine; Cell Differentiation; Cell Movement; Cell Survival; Edaravone; Female; Fluorescent Dyes; Free Radical Scavengers; Nerve Fibers; Neural Stem Cells; Organic Chemicals; Rats; Rats, Sprague-Dawley; Recovery of Function; Spinal Cord; Spinal Cord Injuries; Stem Cell Transplantation; Survival Analysis; Treatment Outcome; Wound Healing | 2015 |
Edaravone, a potent free radical scavenger and a calcium channel blocker attenuate isoproterenol induced myocardial infarction by suppressing oxidative stress, apoptotic signaling and ultrastructural damage.
Topics: Animals; Antipyrine; Apoptosis; C-Reactive Protein; Calcium Channel Blockers; Caspase 3; Dihydropyridines; Edaravone; Female; Free Radical Scavengers; Isoproterenol; Male; Malondialdehyde; Myocardial Infarction; Myocardium; Oxidative Stress; Rats; Rats, Wistar | 2016 |
Sodium Phenylbutyrate and Edaravone Abrogate Chronic Restraint Stress-Induced Behavioral Deficits: Implication of Oxido-Nitrosative, Endoplasmic Reticulum Stress Cascade, and Neuroinflammation.
Topics: Animals; Antipyrine; Chronic Disease; Depression; Dose-Response Relationship, Drug; Edaravone; Endoplasmic Reticulum Stress; Free Radical Scavengers; Inflammation; Male; Mice; Nitrosation; Oxidative Stress; Phenylbutyrates; Restraint, Physical; Stress, Psychological | 2017 |
[The pulmonary injury in rats caused by chronic intermittent hypoxia and the intervention effect of Edaravone].
Topics: Angiotensin II; Animals; Antipyrine; Edaravone; Free Radical Scavengers; Hypoxia; Lung; Lung Injury; Male; Malondialdehyde; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase | 2015 |
Edaravone is a free radical scavenger that protects against laser-induced choroidal neovascularization in mice and common marmosets.
Topics: Animals; Antipyrine; Callithrix; Cell Proliferation; Cells, Cultured; Choroid; Choroidal Neovascularization; Disease Models, Animal; Edaravone; Free Radical Scavengers; Humans; Lasers; Mice; Mice, Inbred C57BL; Oxidative Stress; Reactive Oxygen Species; Retinal Pigment Epithelium; Vascular Endothelial Growth Factor A | 2016 |
A SIRT3/AMPK/autophagy network orchestrates the protective effects of trans-resveratrol in stressed peritoneal macrophages and RAW 264.7 macrophages.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Antioxidants; Antipyrine; Apoptosis; Ascorbic Acid; Autophagy; Edaravone; Gene Expression Regulation; Macrophages; Membrane Potential, Mitochondrial; Mice; Oxidative Stress; Protein Kinases; RAW 264.7 Cells; Reactive Oxygen Species; Resveratrol; Sirolimus; Sirtuin 3; Stilbenes; Stress, Psychological | 2016 |
Could edaravone prevent gentamicin ototoxicity? An experimental study.
Topics: Animals; Antipyrine; Edaravone; Free Radical Scavengers; Gentamicins; Guinea Pigs; Hearing; Male | 2017 |
Edaravone suppresses degradation of type II collagen.
Topics: Antipyrine; Cells, Cultured; Chondrocytes; Collagen Type II; Dose-Response Relationship, Drug; Edaravone; Enzyme Activation; Free Radical Scavengers; Humans; Matrix Metalloproteinase 13; Tumor Necrosis Factor-alpha | 2016 |
Neuroprotective Effects of Isosteviol Sodium Injection on Acute Focal Cerebral Ischemia in Rats.
Topics: Animals; Antipyrine; Brain; Dose-Response Relationship, Drug; Edaravone; Edema; Immunohistochemistry; Infarction, Middle Cerebral Artery; Male; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Regional Blood Flow | 2016 |
Synthesis, molecular properties prediction and anticancer, antioxidant evaluation of new edaravone derivatives.
Topics: Administration, Oral; Antineoplastic Agents; Antioxidants; Antipyrine; Biological Availability; Cell Line, Tumor; Chemistry Techniques, Synthetic; Computer Simulation; Crystallography, X-Ray; Edaravone; Humans; Magnetic Resonance Spectroscopy | 2016 |
Edaravone promotes activation of resident cardiac stem cells by transplanted mesenchymal stem cells in a rat myocardial infarction model.
Topics: Animals; Antipyrine; Apoptosis; Cell Movement; Cells, Cultured; Cytokines; Disease Models, Animal; Edaravone; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Myocardial Infarction; Myocytes, Cardiac; Neovascularization, Physiologic; Paracrine Communication; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Reactive Oxygen Species; Recovery of Function; Regeneration; Signal Transduction; Stem Cells; Time Factors | 2016 |
Influences of acidic reaction and hydrolytic conditions on monosaccharide composition analysis of acidic, neutral and basic polysaccharides.
Topics: Alginates; Animals; Antipyrine; Chitosan; Chondroitin Sulfates; Chromatography, High Pressure Liquid; Edaravone; Hydrolysis; Monosaccharides; Smegmamorpha; Starch | 2016 |
Extraction and characterization of polysaccharides from Semen Cassiae by microwave-assisted aqueous two-phase extraction coupled with spectroscopy and HPLC.
Topics: Antipyrine; Cassia; Chemical Fractionation; Chromatography, High Pressure Liquid; Edaravone; Microwaves; Polysaccharides; Solvents; Spectrum Analysis; Temperature; Time Factors; Water | 2016 |
Protective Effects of Edaravone in Adult Rats with Surgery and Lipopolysaccharide Administration-Induced Cognitive Function Impairment.
Topics: Animals; Antipyrine; Brain; Cognitive Dysfunction; Cytokines; Disease Models, Animal; Edaravone; Free Radical Scavengers; Humans; Inflammation Mediators; Lipopolysaccharides; Male; Malondialdehyde; Nephrectomy; Neuroprotective Agents; Oxidative Stress; Postoperative Complications; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; TOR Serine-Threonine Kinases | 2016 |
Edaravone protects against cobalt chloride-induced dysfunctions in apoptosis and invasion in trophoblast cells.
Topics: Antipyrine; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Line; Cobalt; Edaravone; Humans; Matrix Metalloproteinase 2; Reactive Oxygen Species; Tissue Inhibitor of Metalloproteinase-2; Trophoblasts | 2016 |
Possible Mechanism of Therapeutic Effect of 3-Methyl-1-phenyl-2-pyrazolin-5-one and Bone Marrow Stromal Cells Combination Treatment in Rat Ischemic Stroke Model.
Topics: Animals; Antipyrine; Bone Marrow Cells; Brain Ischemia; Chemokine CXCL12; Disease Models, Animal; Edaravone; Infarction, Middle Cerebral Artery; Male; Mesenchymal Stem Cells; Neurogenesis; Rats; Rats, Sprague-Dawley; Stroke | 2016 |
Identification of structurally closely related monosaccharide and disaccharide isomers by PMP labeling in conjunction with IM-MS/MS.
Topics: Antipyrine; Disaccharides; Edaravone; Free Radical Scavengers; Monosaccharides; Spectrometry, Mass, Electrospray Ionization; Staining and Labeling; Tandem Mass Spectrometry | 2016 |
Early Combined Therapy with Pharmacologically Induced Hypothermia and Edaravone Exerts Neuroprotective Effects in a Rat Model of Intracerebral Hemorrhage.
Topics: Animals; Antipyrine; Apoptosis Regulatory Proteins; Blood-Brain Barrier; Blotting, Western; Brain Edema; Caspase 3; Cerebral Hemorrhage; Collagenases; Combined Modality Therapy; Cytokines; Disease Models, Animal; Edaravone; Hypothermia, Induced; Male; Matrix Metalloproteinase 9; Neuroprotective Agents; Permeability; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley | 2015 |
The antioxidant edaravone prevents cardiac dysfunction by suppressing oxidative stress in type 1 diabetic rats and in high-glucose-induced injured H9c2 cardiomyoblasts.
Topics: Animals; Antioxidants; Antipyrine; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Blood Glucose; Caspase 3; Cell Culture Techniques; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Edaravone; Free Radical Scavengers; Gene Knockdown Techniques; Glucose; Hypertrophy; Insulin; Male; Myocytes, Cardiac; NF-E2-Related Factor 2; Oxidative Stress; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Proto-Oncogene Proteins c-bcl-2; Rats; Reactive Oxygen Species; RNA, Small Interfering; Signal Transduction; Sirtuin 1; Superoxide Dismutase | 2016 |
Stereotactic Administration of Edaravone Ameliorates Collagenase-Induced Intracerebral Hemorrhage in Rat.
Topics: Animals; Antipyrine; Apoptosis; Blood-Brain Barrier; Brain Edema; Cerebral Hemorrhage; Collagenases; Cytokines; Disease Models, Animal; Edaravone; Free Radical Scavengers; Magnetic Resonance Imaging; Male; Microglia; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Stereotaxic Techniques; Time Factors; Treatment Outcome | 2016 |
Edaravone improves survival and neurological outcomes after CPR in a ventricular fibrillation model of rats.
Topics: Animals; Antipyrine; Brain Injuries; Cardiopulmonary Resuscitation; Disease Models, Animal; Edaravone; Free Radical Scavengers; Heart Arrest; Male; Rats; Rats, Sprague-Dawley; Ventricular Fibrillation | 2016 |
Effects of Edaravone on Hippocampal Antioxidants in EL Mice.
Topics: Action Potentials; Animals; Antioxidants; Antipyrine; Edaravone; Electroencephalography; Glutathione Disulfide; Hippocampus; Male; Mice, Mutant Strains; Seizures | 2016 |
Analyses of the cell-wall peptidoglycan structures in three genera Micromonospora, Catenuloplanes, and Couchioplanes belonging to the family Micromonosporaceae by derivatization with FDLA and PMP using LC/MS.
Topics: Antipyrine; Cell Wall; Chemistry Techniques, Analytical; Chromatography, Liquid; Edaravone; Hydrolysis; Leucine; Mass Spectrometry; Micromonospora; Micromonosporaceae; Muramic Acids; Nitro Compounds; Peptidoglycan | 2016 |
Determination of serum glucose by isotope dilution liquid chromatography-tandem mass spectrometry: a candidate reference measurement procedure.
Topics: Antipyrine; Blood Glucose; Carbon Radioisotopes; Chromatography, Liquid; Edaravone; Humans; Limit of Detection; Radioisotope Dilution Technique; Tandem Mass Spectrometry | 2016 |
Edaravone alleviates cisplatin-induced neurobehavioral deficits via modulation of oxidative stress and inflammatory mediators in the rat hippocampus.
Topics: Acetylcholinesterase; Animals; Antipyrine; Behavior, Animal; Biomarkers; Body Weight; Brain-Derived Neurotrophic Factor; Cisplatin; Cognition; Edaravone; Gene Expression Regulation; Heme Oxygenase-1; Hippocampus; Inflammation Mediators; Interleukin-1beta; Male; Neuroprotective Agents; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Psychomotor Performance; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha | 2016 |
Quantitative profiling of O-glycans by electrospray ionization- and matrix-assisted laser desorption ionization-time-of-flight-mass spectrometry after in-gel derivatization with isotope-coded 1-phenyl-3-methyl-5-pyrazolone.
Topics: Antipyrine; Edaravone; Electrophoresis; Gels; Isotope Labeling; Polysaccharides; Sodium Dodecyl Sulfate; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2016 |
Edaravone attenuates hippocampal damage in an infant mouse model of pneumococcal meningitis by reducing HMGB1 and iNOS expression via the Nrf2/HO-1 pathway.
Topics: Animals; Antipyrine; Edaravone; HMGB1 Protein; Meningitis, Pneumococcal; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Nitric Oxide Synthase Type II; Signal Transduction | 2016 |
A free radical scavenger edaravone suppresses systemic inflammatory responses in a rat transient focal ischemia model.
Topics: Animals; Antipyrine; Brain Edema; Cerebral Infarction; Cytokines; Edaravone; Free Radical Scavengers; Inflammation; Interleukin-1beta; Ischemic Attack, Transient; Male; Matrix Metalloproteinase 9; Neuroprotective Agents; Rats, Sprague-Dawley; Up-Regulation | 2016 |
The effects of edaravone in ketamine-induced model of mania in rats.
Topics: Analysis of Variance; Animals; Antimanic Agents; Antipyrine; Bipolar Disorder; Brain; Catalase; Disease Models, Animal; Drug Administration Schedule; Edaravone; Excitatory Amino Acid Antagonists; Exploratory Behavior; Female; Ketamine; Lithium Chloride; Locomotion; Malondialdehyde; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2016 |
Inhibition of plasma lipid oxidation induced by peroxyl radicals, peroxynitrite, hypochlorite, 15-lipoxygenase, and singlet oxygen by clinical drugs.
Topics: Animals; Antioxidants; Antipyrine; Arachidonate 15-Lipoxygenase; Edaravone; Free Radicals; Hypochlorous Acid; Lipid Metabolism; Lipids; Mice; Oxidants; Oxidation-Reduction; Peroxides; Peroxynitrous Acid; Plasma; Probucol; Singlet Oxygen | 2016 |
Development of a novel oral delivery system of edaravone for enhancing bioavailability.
Topics: Administration, Oral; Animals; Antipyrine; Biological Availability; Drug Carriers; Drug Delivery Systems; Drug Liberation; Drug Stability; Edaravone; Glycerides; Humans; Male; Permeability; Rats; Rats, Sprague-Dawley; Solubility; Suspensions | 2016 |
Edaravone injection reverses learning and memory deficits in a rat model of vascular dementia.
Topics: Animals; Antipyrine; Dementia, Vascular; Disease Models, Animal; Edaravone; Fear; L-Lactate Dehydrogenase; Learning Disabilities; Male; Malondialdehyde; Memory Disorders; Rats; Rats, Wistar; Superoxide Dismutase | 2017 |
Edaravone with and without .6 Mg/Kg Alteplase within 4.5 Hours after Ischemic Stroke: A Prospective Cohort Study (PROTECT4.5).
Topics: Aged; Aged, 80 and over; Antipyrine; Brain Ischemia; Cohort Studies; Edaravone; Female; Fibrinolytic Agents; Free Radical Scavengers; Humans; Japan; Male; Middle Aged; Stroke; Time Factors; Tissue Plasminogen Activator; Treatment Outcome | 2017 |
Protective Effect of Edaravone on Glutamate-Induced Neurotoxicity in Spiral Ganglion Neurons.
Topics: Animals; Animals, Newborn; Antipyrine; Apoptosis; Cell Survival; Cells, Cultured; Edaravone; Free Radical Scavengers; Glutamic Acid; Neurons; Rats; Spiral Ganglion | 2016 |
Edaravone reduces astrogliosis and apoptosis in young rats with kaolin-induced hydrocephalus.
Topics: Animals; Antidiarrheals; Antipyrine; Apoptosis; Body Weight; Caspase 3; Disease Models, Animal; Edaravone; Exploratory Behavior; Free Radical Scavengers; Glial Fibrillary Acidic Protein; Gliosis; Hydrocephalus; In Situ Nick-End Labeling; Kaolin; Magnetic Resonance Imaging; Male; Neuroglia; Phosphopyruvate Hydratase; Rats; Rats, Wistar | 2017 |
Streptozotocin Inhibits Electrophysiological Determinants of Excitatory and Inhibitory Synaptic Transmission in CA1 Pyramidal Neurons of Rat Hippocampal Slices: Reduction of These Effects by Edaravone.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antipyrine; CA1 Region, Hippocampal; Edaravone; Electric Capacitance; Excitatory Postsynaptic Potentials; Female; Male; Membrane Potentials; Pyramidal Cells; Rats, Wistar; Streptozocin; Synaptic Transmission | 2016 |
DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Antipyrine; Benzofurans; Binding Sites; Blood-Brain Barrier; Edaravone; Humans; Hydrogen Bonding; Inhibitory Concentration 50; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Protein Binding; Protein Structure, Tertiary | 2017 |
Edaravone attenuates intracerebroventricular streptozotocin-induced cognitive impairment in rats.
Topics: Animals; Antipyrine; Cerebral Cortex; Cholinesterases; Cognitive Dysfunction; Cytokines; Edaravone; Free Radical Scavengers; Hippocampus; Male; Maze Learning; Oxidative Stress; Rats; Rats, Wistar; Reaction Time; Receptors, Cholinergic; rho-Associated Kinases; Streptozocin | 2017 |
Edaravone enhances the viability of ischemia/reperfusion flaps.
Topics: Animals; Antipyrine; Disease Models, Animal; Edaravone; Graft Survival; Ischemic Preconditioning; Male; Malondialdehyde; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase; Surgical Flaps | 2017 |
Antioxidant treatment ameliorates diabetes-induced dysfunction of the vas deferens in a rat model.
Topics: Animals; Antioxidants; Antipyrine; Diabetes Mellitus, Experimental; Edaravone; Male; Malondialdehyde; Oxidative Stress; Rats; Rats, Wistar; Taurine; Vas Deferens | 2018 |
Novel antioxidants' synthesis and their anti-oxidative activity through activating Nrf2 signaling pathway.
Topics: Animals; Antioxidants; Antipyrine; Apoptosis; Buthionine Sulfoximine; Edaravone; Glutamate-Cysteine Ligase; Hydrogen Peroxide; NF-E2-Related Factor 2; Oxidative Stress; PC12 Cells; Protective Agents; Protein Transport; Rats; Reactive Oxygen Species; RNA, Messenger; Signal Transduction; Up-Regulation | 2017 |
A Novel LC-MS-MS Method With an Effective Antioxidant for the Determination of Edaravone, a Free-Radical Scavenger in Dog Plasma and its Application to a Pharmacokinetic Study.
Topics: Animals; Antioxidants; Antipyrine; Chromatography, Liquid; Dogs; Edaravone; Female; Linear Models; Male; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2017 |
Edaravone protects against hyperosmolarity-induced oxidative stress and apoptosis in primary human corneal epithelial cells.
Topics: Adenosine Triphosphate; Antipyrine; Apoptosis; Caspase 3; Edaravone; Epithelial Cells; Epithelium, Corneal; Free Radical Scavengers; Humans; Membrane Potential, Mitochondrial; Mitochondria; Osmolar Concentration; Oxidative Stress; Protective Agents; Reactive Oxygen Species | 2017 |
Edaravone-Encapsulated Agonistic Micelles Rescue Ischemic Brain Tissue by Tuning Blood-Brain Barrier Permeability.
Topics: Animals; Antipyrine; Blood-Brain Barrier; Brain Ischemia; Cells, Cultured; Edaravone; Endothelial Cells; Free Radical Scavengers; Magnetic Resonance Imaging; Mice, Inbred ICR; Micelles; Neuroprotective Agents; Permeability; Treatment Outcome | 2017 |
Edaravone: a new treatment for ALS on the horizon?
Topics: Amyotrophic Lateral Sclerosis; Antipyrine; Edaravone; Free Radical Scavengers; Humans | 2017 |
Compound edaravone alleviates lipopolysaccharide (LPS)-induced acute lung injury in mice.
Topics: Acute Lung Injury; Animals; Antipyrine; Bronchoalveolar Lavage Fluid; Cyclooxygenase 2; Cytokines; Edaravone; Gene Expression Regulation, Enzymologic; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Peroxidase; RAW 264.7 Cells | 2017 |
Lipid-based nanosystem of edaravone: development, optimization, characterization and in vitro/in vivo evaluation.
Topics: Administration, Oral; Antipyrine; Biological Availability; Drug Delivery Systems; Edaravone; Emulsions; Humans; Lipids; Nanostructures; Solubility | 2017 |
Edaravone suppresses retinal ganglion cell death in a mouse model of normal tension glaucoma.
Topics: Animals; Antipyrine; Apoptosis; Disease Models, Animal; Edaravone; Electroretinography; Excitatory Amino Acid Transporter 3; Intraocular Pressure; Low Tension Glaucoma; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuroprotective Agents; Oxidative Stress; Retina; Retinal Ganglion Cells; Tomography, Optical Coherence; Vision Disorders | 2017 |
Protective Effect of Edaravone Against Aβ25-35-Induced Mitochondrial Oxidative Damage in SH-SY5Y Cells.
Topics: Adenosine Triphosphate; Amyloid beta-Peptides; Antipyrine; Apoptosis; Cell Line, Tumor; Cell Shape; Edaravone; Humans; Membrane Potential, Mitochondrial; Mitochondria; Neuroprotective Agents; Oxidative Stress; Peptide Fragments; Reactive Oxygen Species | 2017 |
Edaravone is a candidate agent for spinal muscular atrophy: In vitro analysis using a human induced pluripotent stem cells-derived disease model.
Topics: Animals; Antipyrine; Apoptosis; Disease Models, Animal; Edaravone; Fibroblasts; Humans; Induced Pluripotent Stem Cells; Motor Neurons; Muscular Atrophy, Spinal; Oxidative Stress | 2017 |
Edaravone for treatment of early-stage ALS - Authors' reply.
Topics: Amyotrophic Lateral Sclerosis; Antipyrine; Edaravone; Free Radical Scavengers; Humans | 2017 |
Edaravone for treatment of early-stage ALS.
Topics: Amyotrophic Lateral Sclerosis; Antipyrine; Edaravone; Free Radical Scavengers; Humans | 2017 |
Amyotrophic Lateral Sclerosis: Precise Diagnosis and Individualized Treatment.
Topics: Adaptor Proteins, Signal Transducing; Amyotrophic Lateral Sclerosis; Antipyrine; Autophagy-Related Proteins; C9orf72 Protein; Cell Cycle Proteins; DNA-Binding Proteins; Edaravone; Humans; Membrane Transport Proteins; Mitochondrial Proteins; Profilins; Protein Serine-Threonine Kinases; RNA-Binding Protein FUS; Superoxide Dismutase-1; Transcription Factor TFIIIA; Ubiquitins; Valosin Containing Protein | 2017 |
Edaravone ameliorates compression-induced damage in rat nucleus pulposus cells.
Topics: Aggrecans; Animals; Antipyrine; Apoptosis; Cell Survival; Cells, Cultured; Collagen Type II; Dose-Response Relationship, Drug; Edaravone; Free Radical Scavengers; Gene Expression Regulation; Intervertebral Disc Degeneration; Membrane Potential, Mitochondrial; Nucleus Pulposus; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2017 |
Edaravone Prevents Retinal Degeneration in Adult Mice Following Optic Nerve Injury.
Topics: Animals; Antipyrine; Disease Models, Animal; Edaravone; Free Radical Scavengers; Immunohistochemistry; Injections, Intraocular; MAP Kinase Kinase 1; MAP Kinase Kinase Kinase 5; Mice; Mice, Inbred C57BL; Optic Nerve Injuries; Reactive Oxygen Species; Retina; Retinal Degeneration; Retinal Ganglion Cells; Tomography, Optical Coherence | 2017 |
Edaravone Attenuates the Proinflammatory Response in Amyloid-β-Treated Microglia by Inhibiting NLRP3 Inflammasome-Mediated IL-1β Secretion.
Topics: Amyloid beta-Peptides; Animals; Antipyrine; Caspase 1; CD11b Antigen; Cell Survival; Cells, Cultured; Edaravone; Inflammasomes; Interleukin-1beta; Lipopolysaccharides; Malondialdehyde; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Microglia; Mitochondria; Neurons; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidative Stress; Reactive Oxygen Species; Superoxide Dismutase | 2017 |
Heparan Sulfate and Chondroitin Sulfate Glycosaminoglycans Are Targeted by Bleomycin in Cancer Cells.
Topics: Animals; Antipyrine; Bleomycin; CHO Cells; Chondroitin Sulfates; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; Deuterium; Edaravone; HCT116 Cells; Heparitin Sulfate; HT29 Cells; Humans; Isotope Labeling; Mass Spectrometry | 2017 |
(+)-Borneol improves the efficacy of edaravone against DSS-induced colitis by promoting M2 macrophages polarization via JAK2-STAT3 signaling pathway.
Topics: Animals; Antipyrine; Camphanes; Cell Differentiation; Cells, Cultured; Colitis; Colon; Cytokines; Dextran Sulfate; Drug Combinations; Edaravone; Female; Inflammation; Janus Kinase 2; Macrophages; Mice; Mice, Inbred C57BL; RNA, Small Interfering; Signal Transduction; STAT3 Transcription Factor; Th2 Cells | 2017 |
Edaravone protects the retina against ischemia/reperfusion‑induced oxidative injury through the PI3K/Akt/Nrf2 pathway.
Topics: Animals; Antioxidants; Antipyrine; Cell Membrane; Cell Survival; Edaravone; Gene Expression Regulation; Male; Mice; NF-E2-Related Factor 2; Oxidation-Reduction; Oxidative Stress; Phosphatidylinositol 3-Kinase; Photoreceptor Cells; Proto-Oncogene Proteins c-akt; Rats; Reperfusion Injury; Retina; RNA, Small Interfering | 2017 |
Drug therapy: On the treatment trail for ALS.
Topics: Amyotrophic Lateral Sclerosis; Antipyrine; Benzamides; C9orf72 Protein; Clinical Trials as Topic; Disease Progression; Drug Therapy, Combination; Edaravone; Genetic Therapy; Humans; Imidazoles; Mesenchymal Stem Cells; Motor Neurons; Neuroglia; Off-Label Use; Oligoribonucleotides, Antisense; Piperidines; Precision Medicine; Pyrazines; Pyridines; Riluzole; RNAi Therapeutics; Stem Cell Transplantation; Superoxide Dismutase; Thiazoles; United States; United States Food and Drug Administration | 2017 |
Edaravone: A new drug approved for ALS.
Topics: Amyotrophic Lateral Sclerosis; Antipyrine; Drug Approval; Edaravone; Excitatory Amino Acid Antagonists; Humans; Riluzole | 2017 |
Edaravone attenuates lipopolysaccharide-induced acute respiratory distress syndrome associated early pulmonary fibrosis via amelioration of oxidative stress and transforming growth factor-β1/Smad3 signaling.
Topics: Animals; Antipyrine; Dose-Response Relationship, Drug; Edaravone; Free Radical Scavengers; Lipopolysaccharides; Male; Oxidative Stress; Pulmonary Fibrosis; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Respiratory Distress Syndrome; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta1; Treatment Outcome | 2018 |
Edaravone attenuates oxidative stress induced by chronic cerebral hypoperfusion injury: role of ERK/Nrf2/HO-1 signaling pathway.
Topics: Animals; Antipyrine; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Drug; Edaravone; Free Radical Scavengers; Heme Oxygenase-1; Hippocampus; Male; Malondialdehyde; MAP Kinase Signaling System; Maze Learning; NF-E2-Related Factor 2; Oxidative Stress; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Superoxide Dismutase | 2018 |
Edaravone (Radicava) for ALS.
Topics: Amyotrophic Lateral Sclerosis; Antipyrine; Edaravone; Free Radical Scavengers; Humans; Oxidative Stress; Treatment Outcome | 2017 |
Stress degradation of edaravone: Separation, isolation and characterization of major degradation products.
Topics: Antipyrine; Chromatography, Liquid; Drug Contamination; Drug Stability; Edaravone; Limit of Detection; Linear Models; Reproducibility of Results; Tandem Mass Spectrometry; Temperature | 2018 |
Edaravone, a Synthetic Free Radical Scavenger, Enhances Alteplase-Mediated Thrombolysis.
Topics: Adult; Animals; Antipyrine; Edaravone; Free Radical Scavengers; Humans; Male; Rats; Rats, Sprague-Dawley; Thrombolytic Therapy | 2017 |
Prognostic factors in the early phase of acute encephalopathy.
Topics: Acute Febrile Encephalopathy; Adolescent; Anticonvulsants; Antipyrine; Child; Child, Preschool; Edaravone; Female; Free Radical Scavengers; Glucocorticoids; Humans; Infant; Japan; Male; Prognosis; Retrospective Studies | 2018 |
Free radical scavenger edaravone produces robust neuroprotection in a rat model of spinal cord injury.
Topics: 3,4-Methylenedioxyamphetamine; Analysis of Variance; Animals; Antipyrine; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Edaravone; Evoked Potentials, Motor; Lipid Peroxidation; Male; Neuroprotective Agents; Phosphopyruvate Hydratase; Rats; Rats, Wistar; Recovery of Function; Severity of Illness Index; Spinal Cord; Spinal Cord Injuries; Time Factors | 2018 |
New Drugs 2018, part 1.
Topics: Aminoisobutyric Acids; Antibodies, Monoclonal; Antibodies, Neutralizing; Antipyrine; Benzamides; Benzimidazoles; Broadly Neutralizing Antibodies; Carbamates; Cyclopropanes; Drug Approval; Drug Combinations; Edaravone; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Naltrexone; Natriuretic Peptides; Proline; Pyridines; Pyrrolidines; Quinoxalines; Sofosbuvir; Sulfonamides; United States; United States Food and Drug Administration | 2018 |
Discussing edaravone with the ALS patient: an ethical framework from a U.S. perspective.
Topics: Amyotrophic Lateral Sclerosis; Antipyrine; Clinical Trials as Topic; Cost-Benefit Analysis; Edaravone; Ethics, Clinical; Free Radical Scavengers; Humans; Professional-Patient Relations; Quality of Life; United States | 2018 |
Protective effects of a radical scavenger edaravone on oligodendrocyte precursor cells against oxidative stress.
Topics: Animals; Antipyrine; Brain Ischemia; Edaravone; Free Radical Scavengers; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Oligodendrocyte Precursor Cells; Oxidative Stress; White Matter | 2018 |
Outcome of Acute Ischemic Stroke after the Treatment with Edaravone and 0.6 Mg/Kg Alteplase in Japanese Patients with Diabetes.
Topics: Aged; Aged, 80 and over; Antipyrine; Brain Ischemia; Diabetes Mellitus; Disability Evaluation; Disease Progression; Edaravone; Female; Fibrinolytic Agents; Free Radical Scavengers; Humans; Incidence; Japan; Logistic Models; Male; Middle Aged; Odds Ratio; Product Surveillance, Postmarketing; Prospective Studies; Recovery of Function; Registries; Risk Factors; Stroke; Thrombolytic Therapy; Time Factors; Tissue Plasminogen Activator; Treatment Outcome | 2018 |
Hyperperfusion after Clipping of Aneurysm: A Rare Entity.
Topics: Aged; Aneurysm, Ruptured; Angiography, Digital Subtraction; Antipyrine; Cerebral Angiography; Cerebrovascular Circulation; Cerebrovascular Disorders; Computed Tomography Angiography; Diffusion Magnetic Resonance Imaging; Edaravone; Endoscopy; Glycerol; Hematoma; Humans; Intracranial Aneurysm; Ligation; Male; Neurosurgical Procedures; Perfusion Imaging; Recovery of Function; Subarachnoid Hemorrhage; Therapeutic Irrigation; Treatment Outcome | 2018 |
Optimization of reactions between reducing sugars and 1-phenyl-3-methyl-5-pyrazolone (PMP) by response surface methodology.
Topics: Antipyrine; Edaravone; Kinetics; Reducing Agents; Sugars; Temperature | 2018 |
Mechanisms of the pH- and Oxygen-Dependent Oxidation Activities of Artesunate.
Topics: Antimalarials; Antineoplastic Agents; Antipyrine; Artemisinins; Artesunate; Cell Survival; Edaravone; Free Radical Scavengers; Hep G2 Cells; Humans; Hydrogen-Ion Concentration; Iron; Oxidation-Reduction; Oxygen; Reactive Oxygen Species | 2018 |
Gastric retention pellets of edaravone with enhanced oral bioavailability: Absorption mechanism, development, and in vitro/in vivo evaluation.
Topics: Administration, Oral; Animals; Antipyrine; Biological Availability; Caco-2 Cells; Delayed-Action Preparations; Dogs; Drug Liberation; Edaravone; Free Radical Scavengers; Gastric Mucosa; Humans; Intestinal Absorption; Male; Rats, Sprague-Dawley | 2018 |
Diterpene ginkgolides meglumine injection protects against paraquat-induced lung injury and pulmonary fibrosis in rats.
Topics: Acute Lung Injury; Animals; Antipyrine; Dose-Response Relationship, Drug; Edaravone; Ginkgolides; Interleukin-1beta; Interleukin-6; Male; Malondialdehyde; Meglumine; Pulmonary Edema; Pulmonary Fibrosis; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2018 |
Chitosan/hyaluronan/edaravone membranes for anti-inflammatory wound dressing: In vitro and in vivo evaluation studies.
Topics: Animals; Anti-Inflammatory Agents; Antipyrine; Bandages; Chitosan; Edaravone; Female; Hyaluronic Acid; Rats; Spectroscopy, Fourier Transform Infrared; Thermogravimetry; Wound Healing | 2018 |
Conjugate Eye Deviation Caused by Upper Medial Medullary Infarction: A Case Report.
Topics: Aged; Antipyrine; Aspirin; Brain Stem Infarctions; Cerebral Angiography; Diffusion Magnetic Resonance Imaging; Edaravone; Eye Movements; Female; Fixation, Ocular; Free Radical Scavengers; Humans; Magnetic Resonance Angiography; Medulla Oblongata; Ocular Motility Disorders; Recovery of Function; Treatment Outcome | 2018 |
Edaravone, a cytoprotective drug, enhances transgene expression mediated by lipoplexes in HepG2 cells and mice.
Topics: Animals; Antipyrine; Cytoprotection; DNA; Edaravone; Free Radical Scavengers; Gene Expression; Hep G2 Cells; Humans; Liposomes; Luciferases, Firefly; Male; Mice; Plasmids; Reactive Oxygen Species; Transfection; Transgenes | 2018 |
Edaravone administration in pivotal clinical Study 19.
Topics: Amyotrophic Lateral Sclerosis; Antipyrine; Edaravone; Free Radical Scavengers; Humans | 2019 |
Improvement of a decreased anti-oxidative activity by edaravone in amyotrophic lateral sclerosis patients.
Topics: Amyotrophic Lateral Sclerosis; Antipyrine; Edaravone; Free Radical Scavengers; Humans; Oxidation-Reduction | 2020 |
Protective effect of edaravone on cisplatin-induced injury in rat ovary.
Topics: Animals; Antipyrine; Apoptosis; Caspase 3; Caspase 8; Cisplatin; Edaravone; Female; Malondialdehyde; Nitric Oxide; Ovary; Rats; Rats, Wistar | 2022 |
Efficacy and Safety of Edaravone in Amyotrophic Lateral Sclerosis Patients in Indian Population.
Topics: Amyotrophic Lateral Sclerosis; Animals; Antipyrine; Double-Blind Method; Edaravone; Humans; Neurodegenerative Diseases | 2022 |
Neuroprotection of Oral Edaravone on Middle Cerebral Artery Occlusion in Rats.
Topics: Animals; Antipyrine; Edaravone; Free Radical Scavengers; Infarction, Middle Cerebral Artery; Ischemic Stroke; Male; Neuroprotection; Neuroprotective Agents; Rats | 2022 |
Long-term outcomes of edaravone in amyotrophic lateral sclerosis in South Korea: 72-week observational study.
Topics: Amyotrophic Lateral Sclerosis; Antipyrine; Double-Blind Method; Edaravone; Humans; Neurodegenerative Diseases; Republic of Korea | 2022 |
In brief: Edaravone oral suspension (Radicava ORS) for ALS.
Topics: Amyotrophic Lateral Sclerosis; Antipyrine; Edaravone; Electrolytes; Free Radical Scavengers; Humans; Suspensions | 2022 |
Development of Edaravone Ionic Liquids and Their Application for the Treatment of Cerebral Ischemia/Reperfusion Injury.
Topics: Animals; Antipyrine; Brain Ischemia; Edaravone; Free Radical Scavengers; Ionic Liquids; Ischemic Stroke; Rats; Reperfusion Injury; Tissue Distribution | 2023 |
Antioxidant and Apoptotic Effect of Edaravone on Cisplatin-Induced Brain Injury in Rats.
Topics: Animals; Antioxidants; Antipyrine; Brain Injuries; Cisplatin; Edaravone; Female; Free Radical Scavengers; Ki-67 Antigen; Rats; Rats, Wistar; Tumor Suppressor Protein p53 | 2024 |