antimony-sodium-gluconate and urea-stibamine

antimony-sodium-gluconate has been researched along with urea-stibamine* in 1 studies

Other Studies

1 other study(ies) available for antimony-sodium-gluconate and urea-stibamine

Article	Year
Mode of action of pentavalent antimonials: specific inhibition of type I DNA topoisomerase of Leishmania donovani. Biochemical and biophysical research communications, 1988, Apr-29, Volume: 152, Issue:2 Sodium stibogluconate and Ureastibamine, two potent antileishmanial drugs specifically inhibit the relaxation of supercoiled plasmid pBR322 catalyzed by DNA topoisomerase I of Leishmania donovani. Dose dependent inhibition suggests that the drugs interact with the enzyme rather than the DNA. The inhibition reported here concerning a type I DNA topoisomerase demonstrates at least one possible mode of action of these antileishmanial drugs. Topics: Animals; Antimony; Antimony Sodium Gluconate; DNA Topoisomerases, Type I; Gluconates; Leishmania donovani; Organometallic Compounds; Plasmids; Topoisomerase I Inhibitors; Urea	1988

Article

Year

Mode of action of pentavalent antimonials: specific inhibition of type I DNA topoisomerase of Leishmania donovani.

Biochemical and biophysical research communications, 1988, Apr-29, Volume: 152, Issue:2

Sodium stibogluconate and Ureastibamine, two potent antileishmanial drugs specifically inhibit the relaxation of supercoiled plasmid pBR322 catalyzed by DNA topoisomerase I of Leishmania donovani. Dose dependent inhibition suggests that the drugs interact with the enzyme rather than the DNA. The inhibition reported here concerning a type I DNA topoisomerase demonstrates at least one possible mode of action of these antileishmanial drugs.

Topics: Animals; Antimony; Antimony Sodium Gluconate; DNA Topoisomerases, Type I; Gluconates; Leishmania donovani; Organometallic Compounds; Plasmids; Topoisomerase I Inhibitors; Urea

1988