Compounds > anthranilic acid

anthranilic acid and kynurenine

anthranilic acid has been researched along with kynurenine in 95 studies

Research

Studies (95)

TimeframeStudies, this research(%)All Research%
pre-199029 (30.53)18.7374
1990's11 (11.58)18.2507
2000's13 (13.68)29.6817
2010's31 (32.63)24.3611
2020's11 (11.58)2.80

Authors

AuthorsStudies
Baran, H; Schwarcz, R1
Fukui, S; Rapoport, SI; Schwarcz, R; Smith, QR; Takada, Y1
Abdel-Hamied, HA; Abdel-Tawab, GA; Aboul-Azm, T; Ebied, SA; el-Kholy, ZA; el-Sharaky, AS; el-Toukhy, MA1
Boni, RL; Markey, SP; Naritsin, DB1
Carlà, V; Carpenedo, R; Chiarugi, A; Lombardi, G; Mattoli, L; Moroni, F; Pellicciari, R; Russi, P1
Crowley, JS; Heyes, MP; Markey, SP; Saito, K1
Carpenedo, R; Chiarugi, A; Moroni, F1
Guzeva, VI; Melnikova, NV; Mikhailov, IB1
Koushik, SV; Moore, JA; Phillips, RS; Sundararaju, B1
Goodman, CB; Heyliger, SO; Ngong, JM; Soliman, KF1
Fujigaki, S; Fujii, H; Noma, A; Saito, K; Seishima, M; Takemura, M; Wada, H1
Fujigaki, S; Fujii, H; Saito, K; Seishima, M; Wada, H1
Amiridze, N; Brown, OR; Dale, WE; Dang, Y1
Ansari, MM; Sridhar, R1
Buczko, W; Mysliwiec, P; Pawlak, D; Tankiewicz, A1
Buczko, W; Malyszko, J; Mysliwiec, M; Pawlak, D; Pawlak, K1
Baran, H; Draxler, M; Kepplinger, B; Nohl, H; Staniek, K; Stur, J1
TOMPSETT, SL1
FEDELE, L; QUAGLIARIELLO, E; TANCREDI, F1
LEPPANEN, VV; OKA, M1
HELLSTROM, B; VASSELLA, F; WENGLE, B1
WALLACE, DM; WHITE, RW1
ALLEGRI, G; BENASSI, CA; PERISSINOTTO, B2
CONTRERAS, E; CROXATTO, R; HUIDOBRO, F1
DURKEE, AB; SIROIS, JC1
ALLEGRI, G; BENASSI, CA; BENASSI, P; RABASSINI, A1
CREPALDI, G; PARPAJOLA, A1
MIYATAKE, M; SHIBA, S; TERAWAKI, A1
MENCZYK, Z1
BROWN, RR; HANKES, LV; LIPPINCOTT, S; SCHMAELER, M1
BROWN, RR; FLINN, JH; PRICE, JM; YESS, N1
CLAMP, JR; KOMROWER, GM; WESTALL, RG; WILSON, V1
PALLERONI, NJ; STANIER, RY1
BROWN, RR; BRYAN, GT; MORRIS, CR; PRICE, JM1
BROWN, RR; BRYAN, GT; PRICE, JM1
ANDERSON, JA; DOEDEN, D; DRUMMOND, KN; GOOD, RA; MICHAEL, AF1
ABUL-FADL, MA; KHALAFALLAH, AS1
PINALS, RS1
ALLERT, U; MELCHING, HJ; STREFFER, C1
IVANOVA, VD1
GHOLSON, RK; HAYAISHI, O; ICHIYAMA, A; NISHIZUKA, Y1
CAREDDU, P; MAINARDI, L; TENCONI, LT1
BEAVEN, V; KATZ, E; REDFIELD, B; WEISSBACH, H1
WALSH, MP1
Cerstiaens, A; De Loof, A; Huybrechts, J; Kotanen, S; Lebeau, I; Meylaers, K; Schoofs, L1
Buczko, W; Chabielska, E; Pawlak, D; Tankiewicz, A; Topczewska-Bruns, J1
Bustamante, S; Clark, CJ; Mackay, GM; Phillips, RS; Smythe, GA; Stone, TW1
Darlington, LG; Forrest, CM; Mackay, GM; Oxford, L; Stone, TW; Stoy, N1
da Costa Ferreira, G; de Souza Wyse, AT; Dutra-Filho, CS; Duval Wannmacher, CM; Latini, A; Schuck, PF; Tonin, A; Viegas, CM; Wajner, M1
Farrow, JM; Pesci, EC1
Backhaus, C; Hardeland, R; Laatsch, H; Rahman, H; Scheffler, S1
Kowalewska, A; Mysliwiec, M; Pawlak, D; Pawlak, K1
Molina-Carballo, A; Muñoz-Hoyos, A; Romero, J; Uberos, J1
Bien, B; Gulaj, E; Pawlak, D; Pawlak, K1
Du Preez, JL; Harvey, BH; Möller, M1
Kolodziej, L1
Eussen, SJ; Midttun, Ø; Nygård, O; Tell, GS; Theofylaktopoulou, D; Ueland, PM; Ulvik, A; Vollset, SE1
Fukuwatari, T; Hiratsuka, C; Saito, K; Sano, M; Sasaki, S; Shibata, K1
Dijkhuis, A; Johnston, SL; Karlas, JA; Kulik, W; Lutter, R; Molenkamp, R; Smids, BS; Sterk, PJ; van de Pol, MA; van der Sluijs, KF; van der Zee, JS; van Eijk, HW; Wolthers, KC1
Gregory, JF; Nijhout, HF; Reed, MC; Rios-Avila, L; Sitren, HS1
Aalbers, MW; Aldenkamp, AP; Kessels, AG; Klinkenberg, S; Leenen, L; Majoie, HJ; Rijkers, K; van den Borne, CJ; Verschuure, P; Vles, JS1
Eussen, SJ; Mellgren, G; Meyer, K; Midttun, Ø; Nilsen, DW; Nordrehaug, JE; Nygård, O; Pedersen, ER; Strand, E; Svingen, GF; Tuseth, N; Ueland, PM; Ulvik, A1
Beconi, M; Bonelli, F; Caretti, F; Chan, K; Dominguez, C; Herbst, T; Lyons, K; Monteagudo, E; Munoz-Sanjuan, I; Orsale, MV; Orsatti, L; Speziale, R; Toledo-Sherman, L; Veneziano, M; Zini, M1
Brody, LC; Brosnan, JT; Brosnan, ME; Deac, OM; Fan, R; Gibney, ER; Laird, E; Midttun, Ø; Mills, JL; Molloy, AM; Shane, B; Ueland, PM; Wang, Y1
Astola, N; Cole, JE; Cribbs, AP; Davies, AH; Feldmann, M; Goddard, ME; Green, P; Monaco, C; Park, I; Williams, RO1
Dierkes, J; Drevon, CA; Gudbrandsen, OA; Karlsson, T; Midttun, Ø; Nygård, O; Pedersen, ER; Strand, E; Ueland, PM; Øyen, J1
Buttar, HS; Nayak, BN1
Dabrowska, M; Jasiewicz, M; Kaminski, KA; Kazimierczyk, R; Knapp, M; Moniuszko, M; Musial, WJ; Pawlak, D; Rusak, M1
Kaminski, T; Michalowska, M; Oksztulska-Kolanek, E; Pawlak, D; Znorko, B1
Capi, M; Curto, M; Fazio, F; Giamberardino, MA; Lionetto, L; Martelletti, P; Negro, A; Nicoletti, F; Perugino, F; Simmaco, M1
Capi, M; Curto, M; Fazio, F; Giamberardino, MA; Lionetto, L; Martelletti, P; Negro, A; Nicoletti, F; Simmaco, M1
Budac, DP; Elfving, B; Eskelund, A; Sanchez, C; Wegener, G1
Allorge, D; Bortolotti, P; Dessein, R; Faure, E; Faure, K; Grandjean, T; Guery, BP; Hennart, B; Jausions, G; Kipnis, E; Le Gouellec, A; Thepaut, M; Thieffry, C; Toussaint, B1
Brody, LC; Deac, OM; Fan, R; Gardiner, CM; Lu, Z; McCann, A; Meyer, K; Midttun, Ø; Mills, JL; Molloy, AM; Quinn, L; Shane, B; Ueland, PM1
Bezard, E; Camus, SM; Ceci, A; Fuertig, R; Hengerer, B; Luippold, AH1
Cobb, SR; Dalton, RN; Darlington, LG; Forrest, CM; Kennedy, PG; Rodgers, J; Stone, TW; Turner, C1
Bengesser, SA; Birner, A; Dalkner, N; Fellendorf, FT; Fuchs, D; Hamm, C; Herzog-Eberhard, S; Kapfhammer, HP; Maget, A; Mangge, H; Moll, N; Pilz, R; Platzer, M; Queissner, R; Rauch, P; Reininghaus, B; Reininghaus, EZ; Schütze, G; Schwarz, M; Zelzer, S1
Inglot, M; Laskus, T; Malyszczak, K; Pawlak, D; Pawlowski, T; Radkowski, M; Zalewska, M1
Badawy, AA1
Amore, M; Baldessarini, RJ; Berardelli, I; Curto, M; Erbuto, D; Forte, A; Girardi, P; Innamorati, M; Lionetto, L; Montebovi, F; Pompili, M; Serafini, G; Seretti, ME; Simmaco, M1
Choi, SA; Jee, SH; Jung, KJ; Khan, A; Na, J; Pamungkas, AD; Park, YH1
Baldessarini, RJ; Comparelli, A; Corigliano, V; Curto, M; Fazio, F; Ferracuti, S; Lionetto, L; Nicoletti, F; Simmaco, M1
Allers, KA; Harkin, A; McLoughlin, DM; Ryan, KM1
Hayakawa, K; Nishitani, K; Tanaka, S1
Boscaro, F; Calabresi, P; Di Filippo, M; Gaetani, L; Pieraccini, G; Romani, L; Zelante, T1
Aslamkhan, AG; Bass, A; Bhatt, B; Garfinkel, I; Glaab, WE; LaFranco-Scheuch, L; Li, N; Loughlin, A; Miller, JR; Pacchione, S; Pearson, K; Reynolds, S; Solban, N; Styring, TG; Vu, H; Xu, Q; Zhou, H1
Bugajska, J; Inglot, M; Janocha-Litwin, J; Malyszczak, K; Marciniak, D; Pawlak, D; Pawlowski, T; Zalewska, M1
Di Pasquale, P; Dischinger, K; Dreger, P; Luft, T; Monteagudo, E; Müller-Tidow, C; Orsatti, L; Radujkovic, A; Speziale, R; Stiehl, T1
Aziz, FN; Guillemin, GJ; Jusof, FF; Lim, CK; Raju, CS; Sekaran, SD; Soe, HJ1
Fathi, M; Hajibeygi, R; Jazi, K; Klegeris, A; McElhinney, A; Sayehmiri, F; Shool, S; Sodeifian, F; Tavasol, A; Tavirani, MR; Vakili, K; Yaghoobpoor, S1
Abdel Rahman, A; Alabdaljabar, MS; Dahabiyeh, LA; Hussein, MH; Jacob, M; Nimer, RM; Sabi, EM; Sumaily, KM1
Berenbaum, F; Binvignat, M; Butte, AJ; Courties, A; Crema, MD; Emond, P; Klatzmann, D; Kloppenburg, M; Lefèvre, A; Maheu, E; Mariotti-Ferrandiz, E; Miao, B; Mifsud, F; Richette, P; Sellam, J; Sokol, H1
Bechmann, N; Fröbel, D; Langner, M; Peitzsch, M; Stanke, D; Žygienė, G1
Bakker, L; Choe, K; J P M Eussen, S; Kenis, G; Köhler, S; Ramakers, IHGB; Rutten, BPF; Staals, J; Ueland, PM; Ulvik, A; van den Hove, DLA; van Oostenbrugge, RJ; Verhey, FRJ1

Reviews

2 review(s) available for anthranilic acid and kynurenine

ArticleYear
New insights into tryptophan and its metabolites in the regulation of bone metabolism.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2015, Volume: 66, Issue:6

    Topics: Animals; Bone and Bones; Humans; Kynurenine; Melatonin; ortho-Aminobenzoates; Picolinic Acids; Quinolinic Acid; Serotonin; Tryptophan; Xanthurenates

2015
Dynamic changes in metabolites of the kynurenine pathway in Alzheimer's disease, Parkinson's disease, and Huntington's disease: A systematic Review and meta-analysis.
    Frontiers in immunology, 2022, Volume: 13

    Topics: 3-Hydroxyanthranilic Acid; Adenosine; Alzheimer Disease; Humans; Huntington Disease; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; NAD; Niacinamide; Parkinson Disease; Tryptophan

2022

Trials

2 trial(s) available for anthranilic acid and kynurenine

ArticleYear
Supplementing healthy women with up to 5.0 g/d of L-tryptophan has no adverse effects.
    The Journal of nutrition, 2013, Volume: 143, Issue:6

    Topics: Adolescent; Adult; Biomarkers; Body Mass Index; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Female; Humans; Kynurenic Acid; Kynurenine; Niacinamide; ortho-Aminobenzoates; Placebos; Tryptophan; Young Adult

2013
The effects of vagus nerve stimulation on tryptophan metabolites in children with intractable epilepsy.
    Epilepsy & behavior : E&B, 2014, Volume: 37

    Topics: Adolescent; Affect; Biotransformation; Child; Child, Preschool; Double-Blind Method; Drug Resistance; Electrodes, Implanted; Epilepsy; Female; Humans; Kynurenine; Male; Metabolic Networks and Pathways; ortho-Aminobenzoates; Seizures; Treatment Outcome; Tryptophan; Vagus Nerve Stimulation

2014

Other Studies

91 other study(ies) available for anthranilic acid and kynurenine

ArticleYear
Evidence for the preferential production of 3-hydroxyanthranilic acid from anthranilic acid in the rat brain.
    Advances in experimental medicine and biology, 1991, Volume: 294

    Topics: 3-Hydroxyanthranilic Acid; Animals; Brain; Kynurenine; Male; Mixed Function Oxygenases; Organ Specificity; ortho-Aminobenzoates; Rats; Rats, Inbred Strains; Tryptophan

1991
Blood-brain barrier transport of kynurenines: implications for brain synthesis and metabolism.
    Journal of neurochemistry, 1991, Volume: 56, Issue:6

    Topics: Animals; Biological Transport; Blood-Brain Barrier; Brain; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains

1991
The correlation between certain tryptophan metabolites and the N-nitrosamine content in the urine of bilharzial bladder cancer patients.
    The Journal of urology, 1986, Volume: 135, Issue:4

    Topics: 3-Hydroxyanthranilic Acid; Adult; Aminohippuric Acids; Colorimetry; Humans; Indican; Kynurenic Acid; Kynurenine; Male; Middle Aged; Nitrosamines; ortho-Aminobenzoates; Schistosomiasis haematobia; Tryptophan; Urinary Bladder Neoplasms; Xanthurenates

1986
Pentafluorobenzylation method for quantification of acidic tryptophan metabolites using electron capture negative ion mass spectrometry.
    Analytical chemistry, 1995, Mar-01, Volume: 67, Issue:5

    Topics: Fluorobenzenes; Kynurenic Acid; Kynurenine; Mass Spectrometry; Molecular Structure; ortho-Aminobenzoates; Picolinic Acids; Quaternary Ammonium Compounds; Quinolinic Acid; Tryptophan; Xanthurenates

1995
Inhibitors of kynurenine hydroxylase and kynureninase increase cerebral formation of kynurenate and have sedative and anticonvulsant activities.
    Neuroscience, 1994, Volume: 61, Issue:2

    Topics: Alanine; Animals; Anticonvulsants; Brain Chemistry; Electroshock; Excitatory Amino Acid Antagonists; Hydrolases; Hypnotics and Sedatives; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mixed Function Oxygenases; Motor Activity; Neuroglia; Niacin; ortho-Aminobenzoates; Quinolinic Acid; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate

1994
A mechanism for increased quinolinic acid formation following acute systemic immune stimulation.
    The Journal of biological chemistry, 1993, Jul-25, Volume: 268, Issue:21

    Topics: Animals; Duodenum; Female; Gerbillinae; Hydrocortisone; Immunization; Kidney; Kinetics; Kynurenine; Liver; Lung; ortho-Aminobenzoates; Pokeweed Mitogens; Quinolinic Acid; Spleen

1993
Kynurenine disposition in blood and brain of mice: effects of selective inhibitors of kynurenine hydroxylase and of kynureninase.
    Journal of neurochemistry, 1996, Volume: 67, Issue:2

    Topics: Alanine; Animals; Brain; Enzyme Inhibitors; Hydrolases; Kynurenine; Kynurenine 3-Monooxygenase; Liver; Male; Mice; Mixed Function Oxygenases; ortho-Aminobenzoates

1996
The kynurenines and the seizures.
    Advances in experimental medicine and biology, 1996, Volume: 398

    Topics: Animals; Cerebral Ventricles; Electroencephalography; Hippocampus; Kynurenic Acid; Kynurenine; Microinjections; Neurons; ortho-Aminobenzoates; Penicillin G; Quinolinic Acid; Rats; Seizures

1996
The catalytic mechanism of kynureninase from Pseudomonas fluorescens: insights from the effects of pH and isotopic substitution on steady-state and pre-steady-state kinetics.
    Biochemistry, 1998, Feb-03, Volume: 37, Issue:5

    Topics: Catalysis; Deuterium; Deuterium Oxide; Hydrogen-Ion Concentration; Hydrolases; Kinetics; Kynurenine; ortho-Aminobenzoates; Pseudomonas fluorescens; Solvents; Spectrophotometry; Substrate Specificity

1998
The analgesic effects of tryptophan and its metabolites in the rat.
    Pharmacological research, 1998, Volume: 38, Issue:4

    Topics: Analgesics; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Hypolipidemic Agents; Iron Chelating Agents; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Pain; Picolinic Acids; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Reaction Time; Reflex; Tryptophan; Xanthurenates

1998
Species differences in L-tryptophan-kynurenine pathway metabolism: quantification of anthranilic acid and its related enzymes.
    Archives of biochemistry and biophysics, 1998, Oct-15, Volume: 358, Issue:2

    Topics: Animals; Brain; Chromatography, High Pressure Liquid; Enzyme Activation; Gerbillinae; Guinea Pigs; Humans; Hydrolases; Indoleamine-Pyrrole 2,3,-Dioxygenase; Injections, Intravenous; Kynurenine; Kynurenine 3-Monooxygenase; Macaca mulatta; Male; Mice; Mixed Function Oxygenases; ortho-Aminobenzoates; Rabbits; Rats; Species Specificity; Tryptophan; Tryptophan Oxygenase

1998
Quantification of anthranilic acid and its related enzyme activity in several different species.
    Advances in experimental medicine and biology, 1999, Volume: 467

    Topics: Animals; Brain; Gerbillinae; Guinea Pigs; Hydrolases; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Kynurenine 3-Monooxygenase; Liver; Lung; Macaca mulatta; Male; Mice; Mice, Inbred C57BL; Mixed Function Oxygenases; ortho-Aminobenzoates; Rabbits; Rats; Rats, Sprague-Dawley; Species Specificity; Tryptophan Oxygenase

1999
Evidence that kynurenine pathway metabolites mediate hyperbaric oxygen-induced convulsions.
    Toxicology letters, 2000, Sep-30, Volume: 117, Issue:1-2

    Topics: Animals; Coma; Enzyme Inhibitors; Hyperbaric Oxygenation; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mixed Function Oxygenases; ortho-Aminobenzoates; Rats; Rats, Sprague-Dawley; Seizures; Sulfonamides; Thiazoles; Time Factors; Tryptophan

2000
Some tryptophan pathways in the phytopathogen Xanthomonas oryzae pv. oryzae.
    Folia microbiologica, 2000, Volume: 45, Issue:6

    Topics: Catechols; Chromatography, High Pressure Liquid; Indoleacetic Acids; Kynurenine; ortho-Aminobenzoates; Plant Diseases; Tryptophan; Xanthomonas

2000
Tryptophan metabolism via the kynurenine pathway in experimental chronic renal failure.
    Nephron, 2002, Volume: 90, Issue:3

    Topics: Animals; Chromatography, High Pressure Liquid; Creatinine; Kidney; Kidney Failure, Chronic; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Quinolinic Acid; Rats; Rats, Wistar; Time Factors; Tryptophan; Urea; Xanthurenates

2002
Accumulation of toxic products degradation of kynurenine in hemodialyzed patients.
    International urology and nephrology, 2001, Volume: 33, Issue:2

    Topics: Female; Humans; Kidney; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Quinolinic Acid; Renal Dialysis; Tryptophan; Uremia; Xanthurenates

2001
Kynurenines and the respiratory parameters on rat heart mitochondria.
    Life sciences, 2003, Jan-24, Volume: 72, Issue:10

    Topics: 3-Hydroxyanthranilic Acid; Animals; Free Radical Scavengers; In Vitro Techniques; Kinetics; Kynurenine; Male; Mitochondria, Heart; Mitochondrial Proteins; NAD; ortho-Aminobenzoates; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Succinates; Tryptophan

2003
The determination in urine of some metabolites of tryptophankynurenine, anthranilic acid and 3-hydroxyanthranilic acid- and reference to the presence of o-aminophenol in urine.
    Clinica chimica acta; international journal of clinical chemistry, 1959, Volume: 4, Issue:3

    Topics: 3-Hydroxyanthranilic Acid; Aminobenzoates; Aminophenols; Humans; Kynurenine; ortho-Aminobenzoates; Phenols; Tryptophan

1959
[Possibility of diagnosis of tumors of the bladder by chromatographic revelation of metabolites of the tryptophan-nicotinic acid interrelation].
    Bollettino della Societa italiana di biologia sperimentale, 1960, Jul-31, Volume: 36

    Topics: Humans; Kynurenine; Niacin; ortho-Aminobenzoates; Tryptophan; Urinary Bladder Neoplasms; Urine

1960
Metabolism of tryptophan in cancer of various sites.
    Annales medicinae experimentalis et biologiae Fenniae, 1963, Volume: 41

    Topics: Indoleacetic Acids; Kynurenine; Neoplasms; ortho-Aminobenzoates; Tryptophan; Xanthurenates

1963
Urinary excretion of tryptophan metabolites in the healthy infant.
    Pediatrics, 1962, Volume: 30

    Topics: Chromatography; Humans; Kynurenic Acid; Kynurenine; ortho-Aminobenzoates; Tryptophan; Urine

1962
BIOCHEMICAL ASPECTS OF BLADDER TUMOURS.
    Proceedings of the Royal Society of Medicine, 1963, Volume: 56

    Topics: Glucuronidase; Humans; Kynurenine; ortho-Aminobenzoates; Sulfatases; Urinary Bladder Neoplasms; Urine

1963
THE METABOLISM OF TRYPTOPHAN IN PATIENTS WITH BLADDER CANCER AND OTHER UROLOGICAL DISEASES.
    Clinica chimica acta; international journal of clinical chemistry, 1963, Volume: 8

    Topics: Geriatrics; Humans; Kidney Neoplasms; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Prostatic Neoplasms; Proteins; Tryptophan; Urinary Bladder Diseases; Urinary Bladder Neoplasms; Urine

1963
STUDIES ON MORPHINE. III. ACTION OF METABOLIC PRECURSORS TO SEROTONIN AND NORADRENALINE AND RELATED SUBSTANCES ON THE "ABSTINENCE SYNDROME" TO MORPHINE ON WHITE MICE.
    Archives internationales de pharmacodynamie et de therapie, 1963, Dec-01, Volume: 146

    Topics: Brain; Catecholamines; Dihydroxyphenylalanine; Ergot Alkaloids; Iproniazid; Kynurenine; Lysergic Acid Diethylamide; Methyldopa; Mice; Morphine; Nalorphine; Norepinephrine; ortho-Aminobenzoates; Pharmacology; Phenylalanine; Research; Serotonin; Shikimic Acid; Toxicology; Tryptophan; Tyrosine

1963
THE DETECTION OF SOME INDOLES AND RELATED COMPOUNDS ON PAPER CHROMATOGRAMS.
    Journal of chromatography, 1964, Volume: 13

    Topics: 4-Aminobenzoic Acid; Amino Acids; Chromatography; Citrulline; Indicators and Reagents; Indoleacetic Acids; Indoles; Kynurenine; ortho-Aminobenzoates; Phenols; Quinolines; Research; Thiourea; Tryptophan; Urea; Xanthurenates

1964
TRYPTOPHAN METABOLISM IN SPECIAL PAIRS OF TWINS.
    Clinica chimica acta; international journal of clinical chemistry, 1964, Volume: 9

    Topics: Chromatography; Diseases in Twins; Genetics, Medical; Kynurenic Acid; Kynurenine; Metabolic Diseases; ortho-Aminobenzoates; Proteins; Schizophrenia; Spectrophotometry; Tryptophan; Urine; Xanthurenates

1964
EXCRETION OF TRYPTOPHAN METABOLITES IN DIFFERENT FORMS OF HAEMOBLASTOSIS.
    Clinica chimica acta; international journal of clinical chemistry, 1964, Volume: 9

    Topics: Cortisone; Cyclophosphamide; Genetic Diseases, X-Linked; Hodgkin Disease; Humans; Kynurenic Acid; Kynurenine; Leukemia; Leukemia, Hairy Cell; Leukemia, Lymphoid; Leukemia, Myeloid; Lymphatic Diseases; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Mechlorethamine; Multiple Myeloma; ortho-Aminobenzoates; Phenylbutazone; Polycythemia Vera; Proteins; Pyridoxal Phosphate; Pyridoxine; Sarcoma; Severe Combined Immunodeficiency; Tryptophan; Urine; Xanthurenates

1964
STUDIES ON THE TRYPTOPHAN METABOLISM IN TUMOR-BEARING ANIMALS.
    Gan, 1964, Volume: 55

    Topics: Animals; Kynurenic Acid; Kynurenine; Liver; Neoplasms; Neoplasms, Experimental; Niacin; Nicotinic Acids; ortho-Aminobenzoates; Proteins; Rats; Research; Sarcoma; Tryptophan; Urine; Xanthurenates

1964
A METHOD FOR THE DETERMINATION OF EIGHT TRYPTOPHAN METABOLITES IN BIOLOGICAL FLUIDS.
    Canadian journal of medical technology, 1964, Volume: 26

    Topics: Blood Proteins; Cerebrospinal Fluid Proteins; Chromatography; Humans; Kynurenic Acid; Kynurenine; ortho-Aminobenzoates; Spectrophotometry; Tryptophan; Urine; Xanthurenates

1964
METABOLISM OF 3-HYDROXYANTHRANILIC ACID-CARBOXYL-C14 IN THE HUMAN.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1964, Volume: 115

    Topics: 3-Hydroxyanthranilic Acid; Achondroplasia; Blood; Carbon Isotopes; Chromatography; Hippurates; Humans; Kynurenic Acid; Kynurenine; Metabolism; Niacin; Niacinamide; Nicotinic Acids; ortho-Aminobenzoates; Pyridines; Rats; Research; Tryptophan; Urine; Xanthurenates

1964
URINARY EXCRETION OF TRYPTOPHAN METABOLITES IN PATIENTS WITH RENAL PELVIS AND PARENCHYMA TUMOURS.
    Urologia internationalis, 1964, Volume: 17

    Topics: Chromatography; Humans; Kidney Neoplasms; Kidney Pelvis; Kynurenic Acid; Kynurenine; Neoplasms; ortho-Aminobenzoates; Spectrophotometry; Tryptophan; Urine; Xanthurenates

1964
EXCRETION OF TRYPTOPHAN METABOLITES BY PATIENTS WITH RHEUMATOID ARTHRITIS.
    Arthritis and rheumatism, 1964, Volume: 7

    Topics: Arthritis; Arthritis, Rheumatoid; Biomedical Research; Chromatography; Gout; Hippurates; Indoles; Kynurenic Acid; Kynurenine; Niacin; Nicotinic Acids; ortho-Aminobenzoates; Proteins; Psoriasis; Pyridines; Pyridoxine; Spondylitis; Tryptophan; Urine; Xanthurenates

1964
HYDROXYKYNURENINURIA: A CASE OF ABNORMAL TRYPTOPHAN METABOLISM PROBABLY DUE TO A DEFICIENCY OF KYNURENINASE.
    Archives of disease in childhood, 1964, Volume: 39

    Topics: Amino Acid Metabolism, Inborn Errors; Child; Chromatography; Electrophoresis; Humans; Hydrolases; Kynurenic Acid; Kynurenine; Metabolic Diseases; Niacin; ortho-Aminobenzoates; Proteins; Pyridoxine; Spectrophotometry; Tryptophan; Urine; Xanthurenates

1964
REGULATORY MECHANISMS GOVERNING SYNTHESIS OF THE ENZYMES FOR TRYPTOPHAN OXIDATION BY PSEUDOMONAS FLUORESCENS.
    Journal of general microbiology, 1964, Volume: 35

    Topics: Amidohydrolases; Catechols; Enzymes; Hydrolases; Kynurenine; Lactones; ortho-Aminobenzoates; Proteins; Pseudomonas; Pseudomonas fluorescens; Pyrroles; Tryptophan

1964
IN VIVO ELUTION OF TRYPTOPHAN METABOLITES AND OTHER AROMATIC NITROGEN COMPOUNDS FROM CHOLESTEROL PELLETS IMPLANTED INTO MOUSE BLADDERS.
    Cancer research, 1964, Volume: 24

    Topics: Amines; Animals; Carcinogens; Cholesterol; Fluorenes; Hydroxylamines; Kynurenic Acid; Kynurenine; Metabolism; Mice; Naphthalenes; Nitrogen; Nitrogen Compounds; ortho-Aminobenzoates; Pharmacology; Quinolines; Research; Stearic Acids; Tryptophan; Urinary Bladder; Urinary Bladder Neoplasms; Xanthurenates

1964
MOUSE BLADDER CARCINOGENICITY OF CERTAIN TRYPTOPHAN METABOLITES AND OTHER AROMATIC NITROGEN COMPOUNDS SUSPENDED IN CHOLESTEROL.
    Cancer research, 1964, Volume: 24

    Topics: Amines; Animals; Carcinogens; Cholesterol; Fluorenes; Hydroxylamines; Kynurenic Acid; Kynurenine; Metabolism; Mice; Naphthalenes; Neoplasms; Neoplasms, Experimental; Nitrogen; Nitrogen Compounds; ortho-Aminobenzoates; Pharmacology; Quinolines; Research; Tryptophan; Urinary Bladder Neoplasms; Xanthurenates

1964
TRYPTOPHAN METABOLISM IN MAN.
    The Journal of clinical investigation, 1964, Volume: 43

    Topics: Amino Acid Metabolism, Inborn Errors; Calcium; Child; Glucuronates; Humans; Indican; Indoleacetic Acids; Intestinal Absorption; Kynurenine; Male; Metabolism; ortho-Aminobenzoates; p-Aminohippuric Acid; Pyridines; Tryptophan; Urine; Xanthurenates

1964
STUDIES ON THE URINARY EXCRETION OF CERTAIN TRYPTOPHAN METABOLITES BEFORE AND AFTER TRYPTOPHAN LOADING DOSE IN BILHARZIASIS, BILHARZIAL BLADDER CANCER AND CERTAIN OTHER TYPES OF MALIGNANCIES IN EGYPT.
    British journal of cancer, 1964, Volume: 13

    Topics: Amino Acids; Egypt; Epidemiology; Fluids and Secretions; Humans; Hydroxyindoleacetic Acid; Indoleacetic Acids; Kynurenic Acid; Kynurenine; Neoplasms; ortho-Aminobenzoates; Schistosomiasis; Tryptophan; Urinary Bladder Neoplasms; Urine; Xanthurenates

1964
TRYPTOPHAN METABOLISM IN RHEUMATIC DISEASE.
    Arthritis and rheumatism, 1964, Volume: 7

    Topics: Amino Acids; Arthritis; Arthritis, Rheumatoid; Chromatography; Humans; Kynurenic Acid; Kynurenine; Lupus Erythematosus, Systemic; ortho-Aminobenzoates; Rheumatic Diseases; Scleroderma, Systemic; Tryptophan; Urine; Xanthurenates

1964
[TUDIES ON BIOLOGICAL RADIATION PROTECTION. 53. THE EFFECT OF HISTAMINE ON RADIATION-INDUCED CHANGES IN AMINO ACID METABOLISM].
    Strahlentherapie, 1964, Volume: 124

    Topics: Amino Acids; Histamine; Kynurenic Acid; Kynurenine; Mice; ortho-Aminobenzoates; Pharmacology; Radiation Protection; Research; Urine

1964
DISORDERS OF TRYPTOPHAN METABOLISM IN LEUKAEMIA.
    Acta - Unio Internationalis Contra Cancrum, 1964, Volume: 20

    Topics: Amino Acids; Child; Humans; Indoles; Kynurenine; Leukemia; ortho-Aminobenzoates; Tryptophan

1964
STUDIES ON THE METABOLISM OF THE BENZENE RING OF TRYPTOPHAN IN MAMMALIAN TISSUES. I. ENZYMIC FORMATION OF GLUTARIC ACID FROM 3-HYDROXYANTHRANILIC ACID.
    The Journal of biological chemistry, 1965, Volume: 240

    Topics: 3-Hydroxyanthranilic Acid; Amino Acids; Animals; Benzene; Carbon Dioxide; Carbon Isotopes; Cats; Chromatography; Coenzyme A; Electrophoresis; Glutarates; Keto Acids; Kynurenine; Liver; Metabolism; NAD; ortho-Aminobenzoates; Pseudomonas; Pyridines; Research; Tryptophan

1965
[RESEARCH ON ELIMINATION OF METABOLITES OF THE TRYPTOPHAN TO NICOTINIC ACID PATHWAY IN INFANTS].
    Acta vitaminologica, 1964, Volume: 18

    Topics: Chromatography; Diet; Hippurates; Humans; Infant; Kynurenic Acid; Kynurenine; Metabolism; Niacin; Nicotinic Acids; ortho-Aminobenzoates; Tryptophan; Urine; Vitamins; Xanthurenates

1964
4-METHYL-3-HYDROXYANTHRANILIC ACID, AN INTERMEDIATE IN ACTINOMYCIN BIOSYNTHESIS.
    Biochemical and biophysical research communications, 1965, May-03, Volume: 19

    Topics: Amino Acids; Chromatography; Dactinomycin; Kynurenine; Metabolism; ortho-Aminobenzoates; Pharmacology; Research; Streptomyces; Tryptophan; Valine

1965
SEPARATION AND ESTIMATION OF TRYPTOPHAN-NICOTINIC ACID METABOLITES IN URINE BY THIN-LAYER CHROMATOGRAPHY.
    Clinica chimica acta; international journal of clinical chemistry, 1965, Volume: 11

    Topics: Azo Compounds; Chromatography; Chromatography, Thin Layer; Colorimetry; Humans; Indicators and Reagents; Kynurenine; Niacin; Nicotinic Acids; ortho-Aminobenzoates; Tryptophan; Urine; Xanthurenates

1965
Neurotoxic and neurobehavioral effects of kynurenines in adult insects.
    Biochemical and biophysical research communications, 2003, Dec-26, Volume: 312, Issue:4

    Topics: Animals; Apoptosis; Behavior, Animal; Cell Survival; Cells, Cultured; Diptera; Dose-Response Relationship, Drug; Grasshoppers; Insecta; Kynurenine; Lethal Dose 50; Nervous System; Neurons; Neurotoxicity Syndromes; ortho-Aminobenzoates; Quinolinic Acid; Tryptophan

2003
Kynurenine metabolism in central nervous system in experimental chronic renal failure.
    Advances in experimental medicine and biology, 2003, Volume: 527

    Topics: Animals; Central Nervous System; Central Nervous System Diseases; Kidney Failure, Chronic; Kynurenine; Male; ortho-Aminobenzoates; Rats; Rats, Wistar; Tissue Distribution; Tryptophan

2003
Prolonged survival of a murine model of cerebral malaria by kynurenine pathway inhibition.
    Infection and immunity, 2005, Volume: 73, Issue:8

    Topics: Animals; Chemokine CCL4; Disease Models, Animal; Kynurenine; Kynurenine 3-Monooxygenase; Macrophage Inflammatory Proteins; Malaria, Cerebral; Mice; Mice, Inbred C57BL; Mixed Function Oxygenases; ortho-Aminobenzoates; Picolinic Acids; Plasmodium berghei; Sulfonamides; Thiazoles

2005
Kynurenine pathway metabolism in patients with osteoporosis after 2 years of drug treatment.
    Clinical and experimental pharmacology & physiology, 2006, Volume: 33, Issue:11

    Topics: 3-Hydroxyanthranilic Acid; Aged; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Indomethacin; Kynurenic Acid; Kynurenine; Lipid Peroxidation; Male; Middle Aged; Molecular Structure; Neopterin; ortho-Aminobenzoates; Osteoporosis; Sodium Salicylate; Tryptophan

2006
Kynurenines impair energy metabolism in rat cerebral cortex.
    Cellular and molecular neurobiology, 2007, Volume: 27, Issue:1

    Topics: 3-Hydroxyanthranilic Acid; Animals; Carbon Dioxide; Cerebral Cortex; Electron Transport; Energy Metabolism; Glucose; Kynurenic Acid; Kynurenine; ortho-Aminobenzoates; Rats; Rats, Wistar

2007
Two distinct pathways supply anthranilate as a precursor of the Pseudomonas quinolone signal.
    Journal of bacteriology, 2007, Volume: 189, Issue:9

    Topics: Antibiosis; Artificial Gene Fusion; beta-Galactosidase; Chorismic Acid; Gene Deletion; Gene Expression Regulation, Bacterial; Genetic Complementation Test; Kynurenine; Metabolic Networks and Pathways; Microbial Viability; Models, Biological; ortho-Aminobenzoates; Pseudomonas aeruginosa; Quinolones; Staphylococcus aureus; Tryptophan

2007
NO scavenging by 3-hydroxyanthranilic acid and 3-hydroxykynurenine: N-nitrosation leads via oxadiazoles to o-quinone diazides.
    Nitric oxide : biology and chemistry, 2008, Volume: 19, Issue:3

    Topics: 3-Hydroxyanthranilic Acid; Acetylcysteine; Aminophenols; Chromatography, Thin Layer; Diazonium Compounds; Free Radical Scavengers; Hydrazines; Inflammation; Kynurenine; Magnetic Resonance Imaging; Mass Spectrometry; Nitric Oxide; Nitrites; Nitrosation; Nuclear Magnetic Resonance, Biomolecular; ortho-Aminobenzoates; Oxadiazoles; Quinones; Tryptophan

2008
Kynurenine and its metabolites--kynurenic acid and anthranilic acid are associated with soluble endothelial adhesion molecules and oxidative status in patients with chronic kidney disease.
    The American journal of the medical sciences, 2009, Volume: 338, Issue:4

    Topics: Adult; Aged; Case-Control Studies; Female; Humans; Intercellular Adhesion Molecule-1; Kidney Failure, Chronic; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Oxidative Stress; Vascular Cell Adhesion Molecule-1

2009
Melatonin and elimination of kynurenines in children with Down's syndrome.
    Journal of pediatric endocrinology & metabolism : JPEM, 2010, Volume: 23, Issue:3

    Topics: Child; Child, Preschool; Circadian Rhythm; Down Syndrome; Female; Humans; Kynurenic Acid; Kynurenine; Male; Melatonin; ortho-Aminobenzoates; Oxidative Stress; Serotonin; Tryptophan

2010
Kynurenine and its metabolites in Alzheimer's disease patients.
    Advances in medical sciences, 2010, Volume: 55, Issue:2

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Chromatography, High Pressure Liquid; Female; Humans; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Quinolinic Acid; Tryptophan

2010
Development and validation of a single analytical method for the determination of tryptophan, and its kynurenine metabolites in rat plasma.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2012, Jun-01, Volume: 898

    Topics: 3-Hydroxyanthranilic Acid; Animals; Charcoal; Chromatography, High Pressure Liquid; Depression; Kynurenic Acid; Kynurenine; Linear Models; Male; ortho-Aminobenzoates; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Schizophrenia; Social Isolation; Solid Phase Extraction; Tandem Mass Spectrometry; Tryptophan

2012
An exploratory study of the interplay between decreased concentration of tryptophan, accumulation of kynurenines, and inflammatory arthritis.
    IUBMB life, 2012, Volume: 64, Issue:12

    Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; 3-Hydroxyanthranilic Acid; Animals; Arthritis, Experimental; Gene Expression Regulation; Hydrolases; Inflammation; Kynurenine; Kynurenine 3-Monooxygenase; Lymph Nodes; Mice; Mice, Inbred DBA; Organ Specificity; ortho-Aminobenzoates; RNA, Messenger; Signal Transduction; Spleen; Tryptophan

2012
A community-based study on determinants of circulating markers of cellular immune activation and kynurenines: the Hordaland Health Study.
    Clinical and experimental immunology, 2013, Volume: 173, Issue:1

    Topics: 3-Hydroxyanthranilic Acid; Aged; Aging; Biomarkers; Body Mass Index; Creatinine; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Male; Middle Aged; Motor Activity; Neopterin; Norway; ortho-Aminobenzoates; Reference Values; Smoking; Tryptophan; Xanthurenates

2013
Systemic tryptophan and kynurenine catabolite levels relate to severity of rhinovirus-induced asthma exacerbation: a prospective study with a parallel-group design.
    Thorax, 2013, Volume: 68, Issue:12

    Topics: Adult; Asthma; Biomarkers; Breath Tests; Bronchoalveolar Lavage Fluid; Case-Control Studies; Cytokines; Disease Progression; Eosinophil Cationic Protein; Eosinophils; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Nitric Oxide; ortho-Aminobenzoates; Peroxidase; Picornaviridae Infections; Prospective Studies; Quinolinic Acid; Rhinovirus; Tryptophan; Young Adult

2013
A mathematical model of tryptophan metabolism via the kynurenine pathway provides insights into the effects of vitamin B-6 deficiency, tryptophan loading, and induction of tryptophan 2,3-dioxygenase on tryptophan metabolites.
    The Journal of nutrition, 2013, Volume: 143, Issue:9

    Topics: Animals; Brain; Contraceptives, Oral; Female; Humans; Hydrolases; Intestines; Kynurenic Acid; Kynurenine; Liver; Mice; Models, Theoretical; Muscles; ortho-Aminobenzoates; Rats; Transaminases; Tryptophan; Tryptophan Oxygenase; Vitamin B 6 Deficiency

2013
Associations of plasma kynurenines with risk of acute myocardial infarction in patients with stable angina pectoris.
    Arteriosclerosis, thrombosis, and vascular biology, 2015, Volume: 35, Issue:2

    Topics: Aged; Angina, Stable; Biomarkers; Coronary Angiography; Coronary Artery Disease; Diabetes Mellitus, Type 2; Female; Humans; Incidence; Kynurenine; Linear Models; Logistic Models; Male; Metabolic Syndrome; Middle Aged; Multivariate Analysis; Myocardial Infarction; Norway; ortho-Aminobenzoates; Prediabetic State; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Prospective Studies; Risk Assessment; Risk Factors; Up-Regulation; Xanthurenates

2015
A single-run liquid chromatography mass spectrometry method to quantify neuroactive kynurenine pathway metabolites in rat plasma.
    Journal of pharmaceutical and biomedical analysis, 2015, Mar-25, Volume: 107

    Topics: Animals; Blood-Brain Barrier; Chromatography, High Pressure Liquid; Kynurenic Acid; Kynurenine; ortho-Aminobenzoates; Plasma; Rats; Tryptophan

2015
Tryptophan catabolism and vitamin B-6 status are affected by gender and lifestyle factors in healthy young adults.
    The Journal of nutrition, 2015, Volume: 145, Issue:4

    Topics: 3-Hydroxyanthranilic Acid; Adolescent; Adult; Arginine; Biomarkers; Dietary Supplements; Female; Healthy Volunteers; Humans; Kynurenic Acid; Kynurenine; Life Style; Male; Methionine; ortho-Aminobenzoates; Pyridoxal Phosphate; Sex Factors; Surveys and Questionnaires; Tryptophan; Vitamin B 6; Xanthurenates; Young Adult

2015
Indoleamine 2,3-dioxygenase-1 is protective in atherosclerosis and its metabolites provide new opportunities for drug development.
    Proceedings of the National Academy of Sciences of the United States of America, 2015, Oct-20, Volume: 112, Issue:42

    Topics: Animals; Apolipoproteins E; Atherosclerosis; Cinnamates; Drug Design; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Mice, Knockout; ortho-Aminobenzoates; Real-Time Polymerase Chain Reaction

2015
Associations between intake of fish and n-3 long-chain polyunsaturated fatty acids and plasma metabolites related to the kynurenine pathway in patients with coronary artery disease.
    European journal of nutrition, 2017, Volume: 56, Issue:1

    Topics: 3-Hydroxyanthranilic Acid; Aged; Animals; Biomarkers; Body Mass Index; Cholesterol; Coronary Artery Disease; Cross-Sectional Studies; Energy Intake; Fatty Acids, Omega-3; Female; Fishes; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Neopterin; Norway; Nutrition Assessment; ortho-Aminobenzoates; Seafood; Triglycerides; Tryptophan; Xanthurenates

2017
Evaluation of the antioxidant properties of tryptophan and its metabolites in in vitro assay.
    Journal of complementary & integrative medicine, 2016, Jun-01, Volume: 13, Issue:2

    Topics: Anti-Inflammatory Agents; Antioxidants; Cell Line, Tumor; Cell Proliferation; Enzyme-Linked Immunosorbent Assay; Growth Inhibitors; Humans; Interferon-gamma; Interleukin-6; Kynurenine; Melatonin; Milk, Human; Neuroglia; ortho-Aminobenzoates; Oxygen Radical Absorbance Capacity; Quinolinic Acid; Recombinant Proteins; Tryptophan; Tumor Necrosis Factor-alpha; Xanthurenates

2016
Activity of the kynurenine pathway and its interplay with immunity in patients with pulmonary arterial hypertension.
    Heart (British Cardiac Society), 2016, Volume: 102, Issue:3

    Topics: Adult; Aged; Area Under Curve; Case-Control Studies; Disease Progression; Echocardiography, Doppler; Exercise Test; Female; Flow Cytometry; Humans; Hypertension, Pulmonary; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Prospective Studies; ROC Curve; T-Lymphocytes, Regulatory; Th17 Cells; Tryptophan

2016
Altered serum levels of kynurenine metabolites in patients affected by cluster headache.
    The journal of headache and pain, 2015, Volume: 17

    Topics: Adult; Cluster Headache; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Quinolinic Acid; Tryptophan; Xanthurenates

2015
Altered kynurenine pathway metabolites in serum of chronic migraine patients.
    The journal of headache and pain, 2015, Volume: 17

    Topics: Adult; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Male; Middle Aged; Migraine Disorders; ortho-Aminobenzoates; Quinolinic Acid; Tandem Mass Spectrometry; Tryptophan; Xanthurenates

2015
Female Flinders Sensitive Line rats show estrous cycle-independent depression-like behavior and altered tryptophan metabolism.
    Neuroscience, 2016, 08-04, Volume: 329

    Topics: 5-Hydroxytryptophan; Animals; Anxiety; Brain; Depressive Disorder; Disease Models, Animal; Estrous Cycle; Female; Kynurenine; Male; Motor Activity; ortho-Aminobenzoates; Quinolinic Acid; Rats; Resilience, Psychological; Sex Characteristics; Tryptophan

2016
Tryptophan catabolism in Pseudomonas aeruginosa and potential for inter-kingdom relationship.
    BMC microbiology, 2016, 07-08, Volume: 16, Issue:1

    Topics: Acute Lung Injury; Animals; Disease Models, Animal; Host-Pathogen Interactions; Immunity, Innate; Kynurenic Acid; Kynurenine; Metabolic Networks and Pathways; Mice; Murinae; ortho-Aminobenzoates; Pseudomonas aeruginosa; Pseudomonas Infections; Transaminases; Tryptophan

2016
Serum Immune System Biomarkers Neopterin and Interleukin-10 Are Strongly Related to Tryptophan Metabolism in Healthy Young Adults.
    The Journal of nutrition, 2016, Volume: 146, Issue:9

    Topics: 3-Hydroxyanthranilic Acid; Adolescent; Adult; Biomarkers; Body Mass Index; C-Reactive Protein; Cross-Sectional Studies; Female; Humans; Inflammation; Interleukin-10; Kynurenine; Linear Models; Male; Neopterin; ortho-Aminobenzoates; Pyridoxal Phosphate; Surveys and Questionnaires; Tryptophan; Vitamin B 6; Young Adult

2016
LC-MS/MS-based quantification of kynurenine metabolites, tryptophan, monoamines and neopterin in plasma, cerebrospinal fluid and brain.
    Bioanalysis, 2016, Volume: 8, Issue:18

    Topics: Animals; Brain; Chromatography, High Pressure Liquid; Humans; Kynurenine; Mice, Inbred C57BL; Neopterin; ortho-Aminobenzoates; Quinolinic Acid; Signal Transduction; Tandem Mass Spectrometry; Tryptophan

2016
Kynurenine pathway metabolism following prenatal KMO inhibition and in Mecp2
    Neurochemistry international, 2016, Volume: 100

    Topics: Animals; Autism Spectrum Disorder; Brain; Chromatography, Liquid; Female; Kynurenic Acid; Kynurenine; Methyl-CpG-Binding Protein 2; ortho-Aminobenzoates; Pregnancy; Rats, Wistar; Tandem Mass Spectrometry; Tryptophan

2016
Increased breakdown of kynurenine towards its neurotoxic branch in bipolar disorder.
    PloS one, 2017, Volume: 12, Issue:2

    Topics: Adult; Bipolar Disorder; Brain; Case-Control Studies; Cognition; Depression; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Male; Middle Aged; Multivariate Analysis; ortho-Aminobenzoates; Quinolinic Acid; Tryptophan

2017
Alterations in the metabolism of tryptophan in patients with chronic hepatitis C six months after pegylated interferon-α 2a treatment.
    Psychoneuroendocrinology, 2018, Volume: 97

    Topics: Adult; Antiviral Agents; Depression; Depressive Disorder; Female; Hepatitis C; Hepatitis C, Chronic; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-alpha; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Polyethylene Glycols; Recombinant Proteins; Tryptophan

2018
Hypothesis kynurenic and quinolinic acids: The main players of the kynurenine pathway and opponents in inflammatory disease.
    Medical hypotheses, 2018, Volume: 118

    Topics: Animals; Anti-Inflammatory Agents; Humans; Immunosuppressive Agents; Inflammation; Kynurenic Acid; Kynurenine; Male; Models, Theoretical; ortho-Aminobenzoates; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Wistar; Tryptophan

2018
Tryptophan and Kynurenine Metabolites: Are They Related to Depression?
    Neuropsychobiology, 2019, Volume: 77, Issue:1

    Topics: Adult; Bipolar Disorder; Case-Control Studies; Depressive Disorder, Major; Female; Humans; Hydroxyindoleacetic Acid; Kynurenine; Male; ortho-Aminobenzoates; Suicide, Attempted; Tryptophan; Xanthurenates

2019
Noninvasive Serum Metabolomic Profiling Reveals Elevated Kynurenine Pathway's Metabolites in Humans with Prostate Cancer.
    Journal of proteome research, 2019, 04-05, Volume: 18, Issue:4

    Topics: Aged; Biomarkers, Tumor; Humans; Kynurenine; Male; Metabolome; Metabolomics; Middle Aged; ortho-Aminobenzoates; Principal Component Analysis; Prostate-Specific Antigen; Prostatic Neoplasms; Reproducibility of Results; Tryptophan

2019
Serum xanthurenic acid levels: Reduced in subjects at ultra high risk for psychosis.
    Schizophrenia research, 2019, Volume: 208

    Topics: Adolescent; Adult; Disease Progression; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Prodromal Symptoms; Psychotic Disorders; Quinolinic Acid; Risk; Schizophrenia; Tryptophan; Xanthurenates; Young Adult

2019
Tryptophan metabolite concentrations in depressed patients before and after electroconvulsive therapy.
    Brain, behavior, and immunity, 2020, Volume: 83

    Topics: 3-Hydroxyanthranilic Acid; Affect; Case-Control Studies; Electroconvulsive Therapy; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Picolinic Acids; Quinolinic Acid; Tryptophan; Xanthurenates

2020
Kynurenine, 3-OH-kynurenine, and anthranilate are nutrient metabolites that alter H3K4 trimethylation and H2AS40 O-GlcNAcylation at hypothalamus-related loci.
    Scientific reports, 2019, 12-24, Volume: 9, Issue:1

    Topics: Epigenesis, Genetic; Genetic Loci; Glycosylation; Histones; Humans; Hypothalamus; Induced Pluripotent Stem Cells; Kynurenine; Methylation; ortho-Aminobenzoates

2019
Host and Microbial Tryptophan Metabolic Profiling in Multiple Sclerosis.
    Frontiers in immunology, 2020, Volume: 11

    Topics: Adult; Biomarkers; Female; Gastrointestinal Microbiome; Humans; Italy; Kynurenine; Male; Metabolomics; Multiple Sclerosis; ortho-Aminobenzoates; Prospective Studies; Recurrence; Serotonin; Tryptophan; Young Adult

2020
Characterization of indoleamine-2,3-dioxygenase 1, tryptophan-2,3-dioxygenase, and Ido1/Tdo2 knockout mice.
    Toxicology and applied pharmacology, 2020, 11-01, Volume: 406

    Topics: Animals; Female; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Liver; Male; Metabolic Networks and Pathways; Metabolomics; Mice, Knockout; ortho-Aminobenzoates; Serotonin; Spleen; Tryptophan; Tryptophan Oxygenase

2020
The role of anthranilic acid in the increase of depressive symptoms and major depressive disorder during treatment for hepatitis C with pegylated interferon-α2a and oral ribavirin.
    Journal of psychiatry & neuroscience : JPN, 2021, 01-18, Volume: 46, Issue:1

    Topics: Adult; Antiviral Agents; Cross-Sectional Studies; Depression; Depressive Disorder, Major; Female; Hepatitis C, Chronic; Humans; Immunologic Factors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-alpha; Kynurenic Acid; Kynurenine; Longitudinal Studies; Male; Middle Aged; ortho-Aminobenzoates; Polyethylene Glycols; Recombinant Proteins; Ribavirin; Tryptophan

2021
Kynurenine pathway activation and deviation to anthranilic and kynurenic acid in fibrosing chronic graft-versus-host disease.
    Cell reports. Medicine, 2021, 10-19, Volume: 2, Issue:10

    Topics: Adolescent; Adult; Aged; Chemokine CXCL9; Female; Fibrosis; Gene Expression Regulation; Graft vs Host Disease; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interleukin-18; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Leukemia; Lymphoma; Male; Metabolic Networks and Pathways; Middle Aged; ortho-Aminobenzoates; Retrospective Studies; Riboflavin; Severity of Illness Index; Signal Transduction; Stem Cell Transplantation; Transplantation, Homologous; Tryptophan; Vitamin B 6

2021
The Cytokines CXCL10 and CCL2 and the Kynurenine Metabolite Anthranilic Acid Accurately Predict Patients at Risk of Developing Dengue With Warning Signs.
    The Journal of infectious diseases, 2022, 11-28, Volume: 226, Issue:11

    Topics: Chemokine CCL2; Chemokine CXCL10; Cytokines; Humans; Interferon-gamma; Interleukin-18; Kynurenine; Severe Dengue; Tryptophan

2022
Metabolomics profiling distinctively identified end-stage renal disease patients from chronic kidney disease patients.
    Scientific reports, 2023, 04-15, Volume: 13, Issue:1

    Topics: Biomarkers; Disease Progression; Glomerular Filtration Rate; Humans; Kidney Failure, Chronic; Kynurenine; Renal Dialysis; Renal Insufficiency, Chronic; Risk Factors

2023
Serum tryptophan metabolites are associated with erosive hand osteoarthritis and pain: results from the DIGICOD cohort.
    Osteoarthritis and cartilage, 2023, Volume: 31, Issue:8

    Topics: Cross-Sectional Studies; Humans; Kynurenine; Osteoarthritis; Pain; Serotonin; Tryptophan

2023
Liquid chromatography-tandem mass spectrometry based simultaneous quantification of tryptophan, serotonin and kynurenine pathway metabolites in tissues and cell culture systems.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2023, Sep-01, Volume: 1229

    Topics: Animals; Chromatography, Liquid; Dioxygenases; Kynurenine; Mice; Niacin; Reproducibility of Results; Serotonin; Tandem Mass Spectrometry; Tryptophan

2023
The role of the kynurenine pathway in cognitive functioning after stroke: A prospective clinical study.
    Journal of the neurological sciences, 2023, Nov-15, Volume: 454

    Topics: Biomarkers; Cognition; Female; Humans; Kynurenic Acid; Kynurenine; Male; Prospective Studies; Stroke

2023