Compounds > annatto
Page last updated: 2024-08-26

annatto and tocotrienols

annatto has been researched along with tocotrienols in 27 studies

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's17 (62.96)24.3611
2020's10 (37.04)2.80

Authors

AuthorsStudies
Barucca, A; Galli, F; Orlando, F; Pierpaoli, E; Provinciali, M; Viola, V1
Chin, KY; Ima-Nirwana, S1
Akoh, CC; Zou, L1
Abdul-Majeed, S; Chin, KY; Fozi, NF; Ima-Nirwana, S1
Dolde, D; Hansen, H; Prusa, K; Wang, T; Xin, H1
Sato, A; Sato, C; Shiozawa, S; Sugahara, R; Uchida, A; Virgona, N; Yano, T1
Aminuddin, SA; Chin, KY; Ern, SL; Gengatharan, D; Ima-Nirwana, S; Khairussam, RA; Mohd Nasru, FS1
Abdul-Majeed, S; Chin, KY; Ima-Nirwana, S; Mohamed, N1
Bakota, EL; Hwang, HS; Winkler-Moser, JK1
Chin, KY; Ima-Nirwana, S; Mohamad, NV3
Chin, KY; Mohamad, NV; Soelaiman, IN1
Abbasi, M; Felton, CK; Hao, L; Khan, MS; Mo, H; Romero, AW; Scott, S; Shen, CL; Tomison, MD; Wang, S; Yang, S1
Ahmad, F; Chin, KY; Ima-Nirwana, S; Suhaimi, FH; Wong, SK1
Chung, E; Dufour, JM; Kaur, G; Mo, H; Moustaid-Moussa, N; Ramalingam, L; Sharma, S; Shen, CL; Tomison, MD; Wanders, D1
Campise, SN; Chung, E; Cole, L; Dufour, JM; Joiner, HE; Kaur, G; Moustaid-Moussa, N; Ramalingam, L; Shen, CL; Tomison, MD1
Abas, NH; Abdul Hamid, J; Afian Mokhtar, S; Chin, KY; Ima Nirwana, S; Japar Sidik, FZ; Mohd Ramli, ES; Rajalingham, S; Wong, SK1
Chin, KY; Ima-Nirwana, S; Wong, SK1
Ishitsuka, A; Kohno, K; Ota, M; Sekine, M; Virgona, N; Yamada, W; Yano, T1
Alhaj-Saleh, A; Aryaie, A; Lee, J; Moore, L; Shankar, K; Shen, CL; Tinsley, G; Wang, R; Watkins, BA; Wood, SR1
Abd Ghafar, N; Chin, KY; Soelaiman, IN; Wan Hasan, WN1
Chung, E; Dufour, JM; Elmassry, MM; Hamood, AN; Kaur, G; Kottapalli, KR; Kottapalli, P; Moustaid-Moussa, N; Ramalingam, L; Shen, CL; Wang, R; Wright, K1
Cao, JJ; Chung, E; Elmassry, MM; Hamood, AN; Shen, CL1
Dufour, JM; Kaur, G; Mo, H; Ramamoorthy, S; Shen, CL; Wang, R; Watkins, BA1
Batista, MA; Carvalho, JCT; da Silva Hage-Melim, LI; da Silva, HR; de Lima Teixeira Dos Santos, AVT; do Nascimento, AL; Moreira, LF; Pereira, ACM; Souza, IRS1
Abd Ghafar, N; Chin, KY; Foong, LC; Law, JX; Leong, LM; Pang, KL; Soelaiman, IN1

Trials

2 trial(s) available for annatto and tocotrienols

ArticleYear
A 12-week evaluation of annatto tocotrienol supplementation for postmenopausal women: safety, quality of life, body composition, physical activity, and nutrient intake.
    BMC complementary and alternative medicine, 2018, Jun-28, Volume: 18, Issue:1

    Topics: Aged; Bixaceae; Body Composition; Carotenoids; Dietary Supplements; Exercise; Female; Humans; Middle Aged; Plant Extracts; Postmenopause; Quality of Life; Tocotrienols

2018
Actions of annatto-extracted tocotrienol supplementation on obese postmenopausal women: study protocol for a double-blinded, placebo-controlled, randomised trial.
    BMJ open, 2020, 03-08, Volume: 10, Issue:3

    Topics: Adult; Biomarkers; Bixaceae; Body Weights and Measures; C-Reactive Protein; Carnitine O-Palmitoyltransferase; Carotenoids; Double-Blind Method; Endocannabinoids; Fatty Acid Synthases; Female; Humans; Leptin; Lipids; Middle Aged; Obesity; Oxylipins; Plant Extracts; Postmenopause; Tocotrienols

2020

Other Studies

25 other study(ies) available for annatto and tocotrienols

ArticleYear
Effect of annatto-tocotrienols supplementation on the development of mammary tumors in HER-2/neu transgenic mice.
    Carcinogenesis, 2013, Volume: 34, Issue:6

    Topics: Adenocarcinoma; Animals; Antioxidants; Apoptosis; Bixaceae; Breast; Breast Neoplasms; Carotenoids; Cell Line, Tumor; Cell Proliferation; Cellular Senescence; Chemoprevention; Dietary Supplements; Female; Food Coloring Agents; Gene Expression Regulation, Neoplastic; Humans; Mammary Neoplasms, Animal; Mammary Neoplasms, Experimental; Mice; Mice, Transgenic; Oxidative Stress; Plant Extracts; Reactive Oxygen Species; Receptor, ErbB-2; RNA, Messenger; Tissue Distribution; Tocotrienols

2013
Effects of annatto-derived tocotrienol supplementation on osteoporosis induced by testosterone deficiency in rats.
    Clinical interventions in aging, 2014, Volume: 9

    Topics: Animals; Biomarkers; Bixaceae; Bone Density; Bone Remodeling; Carotenoids; Collagen Type I; Dietary Supplements; Femur; Male; Orchiectomy; Osteocalcin; Osteoporosis; Peptides; Plant Extracts; Random Allocation; Rats; Rats, Sprague-Dawley; Testosterone; Tibia; Tocotrienols; X-Ray Microtomography

2014
Antioxidant activities of annatto and palm tocotrienol-rich fractions in fish oil and structured lipid-based infant formula emulsion.
    Food chemistry, 2015, Feb-01, Volume: 168

    Topics: Antioxidants; Bixaceae; Carotenoids; Chromans; Dietary Fats, Unsaturated; Emulsions; Fish Oils; Humans; Infant; Infant Formula; Oxidation-Reduction; Palm Oil; Plant Extracts; Plant Oils; Tocopherols; Tocotrienols

2015
Annatto tocotrienol improves indices of bone static histomorphometry in osteoporosis due to testosterone deficiency in rats.
    Nutrients, 2014, Nov-10, Volume: 6, Issue:11

    Topics: Administration, Oral; Animals; Bixaceae; Bone and Bones; Bone Remodeling; Bone Resorption; Carotenoids; Disease Models, Animal; Male; Orchiectomy; Osteoporosis; Plant Extracts; Rats; Rats, Sprague-Dawley; Testosterone; Tocotrienols

2014
Supplementation of laying-hen feed with annatto tocotrienols and impact of α-tocopherol on tocotrienol transfer to egg yolk.
    Journal of agricultural and food chemistry, 2015, Mar-11, Volume: 63, Issue:9

    Topics: alpha-Tocopherol; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Bixaceae; Carotenoids; Chickens; Dietary Supplements; Egg Yolk; Female; Plant Extracts; Tocotrienols

2015
Annatto Tocotrienol Induces a Cytotoxic Effect on Human Prostate Cancer PC3 Cells via the Simultaneous Inhibition of Src and Stat3.
    Journal of nutritional science and vitaminology, 2015, Volume: 61, Issue:6

    Topics: Antineoplastic Agents; Apoptosis; Bixaceae; Carotenoids; Cell Cycle; Cell Line, Tumor; Genes, src; Humans; Male; Plant Extracts; Prostatic Neoplasms; STAT3 Transcription Factor; Tocotrienols; Vitamin E; Vitamins

2015
The Effects of Annatto Tocotrienol on Bone Biomechanical Strength and Bone Calcium Content in an Animal Model of Osteoporosis Due to Testosterone Deficiency.
    Nutrients, 2016, Dec-14, Volume: 8, Issue:12

    Topics: Androgens; Animals; Bixaceae; Bone and Bones; Bone Density; Calcium; Carotenoids; Disease Models, Animal; Femur; Male; Orchiectomy; Osteoporosis; Plant Extracts; Random Allocation; Rats; Rats, Sprague-Dawley; Testosterone; Tibia; Tocotrienols

2016
The Effects of Tocotrienol and Lovastatin Co-Supplementation on Bone Dynamic Histomorphometry and Bone Morphogenetic Protein-2 Expression in Rats with Estrogen Deficiency.
    Nutrients, 2017, Feb-15, Volume: 9, Issue:2

    Topics: Animals; Bixaceae; Bone and Bones; Bone Morphogenetic Protein 2; Carotenoids; Dietary Supplements; Estrogens; Female; Lovastatin; Ovariectomy; Plant Extracts; Rats; Rats, Sprague-Dawley; Tocotrienols

2017
Stability and Antioxidant Activity of Annatto (Bixa orellana L.) Tocotrienols During Frying and in Fried Tortilla Chips.
    Journal of food science, 2018, Volume: 83, Issue:2

    Topics: Aldehydes; Antioxidants; Bixaceae; Carotenoids; Consumer Behavior; Food Additives; Food Handling; Food Storage; Hot Temperature; Humans; Plant Extracts; Recommended Dietary Allowances; Soybean Oil; Sunflower Oil; Taste; Tocotrienols

2018
Effect of tocotrienol from
    Drug design, development and therapy, 2018, Volume: 12

    Topics: Animals; Bixaceae; Bone and Bones; Buserelin; Calcium; Carotenoids; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Molecular Structure; Osteoporosis; Plant Extracts; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Tocotrienols

2018
Effects of tocotrienol from Bixa orellana (annatto) on bone histomorphometry in a male osteoporosis model induced by buserelin.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 103

    Topics: Animals; Bixaceae; Bone Remodeling; Buserelin; Carotenoids; Disease Models, Animal; Fertility Agents, Female; Male; Osteoporosis; Plant Extracts; Rats; Rats, Sprague-Dawley; Sex Factors; Tocotrienols; Treatment Outcome

2018
Exploring the potential of tocotrienol from Bixa orellana as a single agent targeting metabolic syndrome and bone loss.
    Bone, 2018, Volume: 116

    Topics: Adiponectin; Animals; Bixaceae; Bone Resorption; Cancellous Bone; Carotenoids; Diet, High-Fat; Dietary Carbohydrates; Hyperglycemia; Hypertension; Inflammation; Leptin; Male; Metabolic Syndrome; Osteoblasts; Plant Extracts; Rats, Wistar; Tocotrienols; X-Ray Microtomography

2018
Annatto-extracted tocotrienols improve glucose homeostasis and bone properties in high-fat diet-induced type 2 diabetic mice by decreasing the inflammatory response.
    Scientific reports, 2018, 07-27, Volume: 8, Issue:1

    Topics: Animals; Biomarkers; Bixaceae; Blood Glucose; Body Weight; Bone and Bones; Bone Remodeling; Carotenoids; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Feeding Behavior; Homeostasis; Inflammation; Liver; Male; Mice, Inbred C57BL; Pancreas; Plant Extracts; RNA, Messenger; Tocotrienols; Water

2018
Effect of annatto-extracted tocotrienols and green tea polyphenols on glucose homeostasis and skeletal muscle metabolism in obese male mice.
    The Journal of nutritional biochemistry, 2019, Volume: 67

    Topics: Animals; Bixaceae; Carotenoids; Eating; Enzymes; Glucose; Glucose Intolerance; Homeostasis; Male; Mice, Inbred C57BL; Muscle, Skeletal; Obesity; Oxidative Stress; Pancreas; Plant Extracts; Polyphenols; Tea; Tocotrienols

2019
The Effects of Annatto Tocotrienol Supplementation on Cartilage and Subchondral Bone in an Animal Model of Osteoarthritis Induced by Monosodium Iodoacetate.
    International journal of environmental research and public health, 2019, 08-13, Volume: 16, Issue:16

    Topics: Animals; Bixaceae; Bone and Bones; Carotenoids; Cartilage, Articular; Disease Models, Animal; Male; Osteoarthritis; Plant Extracts; Rats; Rats, Sprague-Dawley; Tocotrienols

2019
The Effects of Tocotrienol on Bone Peptides in a Rat Model of Osteoporosis Induced by Metabolic Syndrome: The Possible Communication between Bone Cells.
    International journal of environmental research and public health, 2019, 09-09, Volume: 16, Issue:18

    Topics: Animals; Bixaceae; Bone Morphogenetic Proteins; Carotenoids; Disease Models, Animal; Fibroblast Growth Factors; Genetic Markers; Intercellular Signaling Peptides and Proteins; Male; Metabolic Syndrome; Osteocytes; Osteoporosis; Osteoprotegerin; Parathyroid Hormone; Plant Extracts; RANK Ligand; Rats, Wistar; Tibia; Tocotrienols

2019
Tocotrienol-rich fraction from annatto ameliorates expression of lysyl oxidase in human osteoblastic MG-63 cells.
    Bioscience, biotechnology, and biochemistry, 2020, Volume: 84, Issue:3

    Topics: Bixaceae; Carotenoids; Cell Line; Humans; Osteoblasts; Plant Extracts; Protein-Lysine 6-Oxidase; Tocotrienols

2020
Annatto-Derived Tocotrienol Promotes Mineralization of MC3T3-E1 Cells by Enhancing BMP-2 Protein Expression via Inhibiting RhoA Activation and HMG-CoA Reductase Gene Expression.
    Drug design, development and therapy, 2020, Volume: 14

    Topics: 3T3 Cells; Animals; Bixaceae; Bone Morphogenetic Protein 2; Carotenoids; Cells, Cultured; Dose-Response Relationship, Drug; Hydroxymethylglutaryl CoA Reductases; Mice; Molecular Structure; Plant Extracts; rhoA GTP-Binding Protein; Structure-Activity Relationship; Tocotrienols

2020
Metabolic benefits of annatto-extracted tocotrienol on glucose homeostasis, inflammation, and gut microbiome.
    Nutrition research (New York, N.Y.), 2020, Volume: 77

    Topics: Adipokines; Adipose Tissue, White; Animals; Bacteria; Bixaceae; Blood Glucose; Body Weight; Carotenoids; Diet, Fat-Restricted; Diet, High-Fat; Dietary Supplements; Gastrointestinal Microbiome; Homeostasis; Inflammation; Male; Metformin; Mice; Mice, Inbred C57BL; Pancreas; Plant Extracts; Tocotrienols

2020
Osteoprotective effect of green tea polyphenols and annatto-extracted tocotrienol in obese mice is associated with enhanced microbiome vitamin K
    The Journal of nutritional biochemistry, 2020, Volume: 86

    Topics: Animals; Bixaceae; Body Weight; Bone and Bones; Carotenoids; Clostridiales; Collagen Type I; DNA; Femur; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Microbiota; Peptide Fragments; Plant Extracts; Polyphenols; RNA, Ribosomal, 16S; Tea; Tocotrienols; Vitamin K 2; X-Ray Microtomography

2020
Therapeutic potential of annatto tocotrienol with self-emulsifying drug delivery system in a rat model of postmenopausal bone loss.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 137

    Topics: Absorptiometry, Photon; Animals; Bixaceae; Bone and Bones; Bone Density Conservation Agents; Calcium; Carotenoids; Drug Delivery Systems; Emulsions; Female; Humans; Malondialdehyde; Osteoporosis, Postmenopausal; Ovariectomy; Plant Extracts; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Selective Estrogen Receptor Modulators; Tocotrienols; X-Ray Microtomography

2021
Dietary Annatto-Extracted Tocotrienol Reduces Inflammation and Oxidative Stress, and Improves Macronutrient Metabolism in Obese Mice: A Metabolic Profiling Study.
    Nutrients, 2021, Apr-13, Volume: 13, Issue:4

    Topics: Animals; Antioxidants; Bixaceae; Carotenoids; Diet, High-Fat; Dietary Supplements; Disease Models, Animal; Humans; Inflammation; Male; Mice; Mice, Inbred C57BL; Nutrients; Obesity; Oxidative Stress; Plant Extracts; Tocotrienols

2021
Self-emulsified annatto tocotrienol improves bone histomorphometric parameters in a rat model of oestrogen deficiency through suppression of skeletal sclerostin level and RANKL/OPG ratio.
    International journal of medical sciences, 2021, Volume: 18, Issue:16

    Topics: Animals; Bixaceae; Bone and Bones; Bone Density; Bone Morphogenetic Proteins; Carotenoids; Disease Models, Animal; Emulsions; Estradiol; Female; Genetic Markers; Humans; Osteoporosis, Postmenopausal; Osteoprotegerin; Plant Extracts; RANK Ligand; Rats; Rats, Sprague-Dawley; Signal Transduction; Tocotrienols

2021
Potential of the Compounds from
    Molecules (Basel, Switzerland), 2022, Feb-28, Volume: 27, Issue:5

    Topics: Bixaceae; Carotenoids; Diterpenes; Dyslipidemias; Molecular Docking Simulation; Plant Extracts; Tocotrienols

2022
Transcriptomic Analysis of the Anticancer Effects of Annatto Tocotrienol, Delta-Tocotrienol and Gamma-Tocotrienol on Chondrosarcoma Cells.
    Nutrients, 2022, Oct-13, Volume: 14, Issue:20

    Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Chondrosarcoma; Humans; Tocotrienols; Transcriptome; Vitamin E

2022